MT1G

Summary

Gene Symbol: MT1G
Description: metallothionein 1G
Alias: MT1, MT1K, metallothionein-1G, MT-1G, MT-1K, MT-IG, metallothionein-1K, metallothionein-IG
Species: human
Products:     MT1G

Top Publications

  1. Huang Y, de la Chapelle A, Pellegata N. Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. Int J Cancer. 2003;104:735-44 pubmed
    ..Loss of expression of MT1G and CRABP1 is accompanied by hypermethylation in the 5' regions of these genes, but methylation was not seen in ..
  2. Ferrario C, Lavagni P, Gariboldi M, Miranda C, Losa M, Cleris L, et al. Metallothionein 1G acts as an oncosupressor in papillary thyroid carcinoma. Lab Invest. 2008;88:474-81 pubmed publisher
    ..of MT downregulation was addressed employing an experimental model made of the PTC-derived K1 cell line in which MT1G expression is repressed by promoter methylation...
  3. Kanda M, Nomoto S, Okamura Y, Nishikawa Y, Sugimoto H, Kanazumi N, et al. Detection of metallothionein 1G as a methylated tumor suppressor gene in human hepatocellular carcinoma using a novel method of double combination array analysis. Int J Oncol. 2009;35:477-83 pubmed
    ..of heterozygosity since no deletions were detected in 16q13, and HCC tissue showed AB call in both SNPs next to MT1G. In quantitative real-time PCR using 48 HCC clinical samples, mRNA expression of MT1G decreased significantly ..
  4. West A, Stallings R, Hildebrand C, Chiu R, Karin M, Richards R. Human metallothionein genes: structure of the functional locus at 16q13. Genomics. 1990;8:513-8 pubmed
    ..This analysis defines the genetic limits of metallothionein functional diversity in the human genome. ..
  5. Panossian A, Seo E, Efferth T. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. Phytomedicine. 2018;50:257-284 pubmed publisher
    ..tested activated the melatonin signaling pathway by acting through two G-protein-coupled membrane receptors MT1 and MT2 and upregulation of the ligand-specific nuclear receptor RORA, which plays a role in intellectual ..
  6. Singh P, Gupta S, Sharma B. Melatonin receptor and KATP channel modulation in experimental vascular dementia. Physiol Behav. 2015;142:66-78 pubmed publisher
    ..In the central nervous system, melatonin (MT1/MT2) as well as serotonin subtype 2C (5-HT2C) receptors is pharmacologically associated with various neurological ..
  7. Korf H. Signaling pathways to and from the hypophysial pars tuberalis, an important center for the control of seasonal rhythms. Gen Comp Endocrinol. 2018;258:236-243 pubmed publisher
    ..Melatonin controls the functional activity of the mammalian PT by acting upon MT1 melatonin receptors. The PT sends its output signals via retrograde and anterograde pathways...
  8. Luo C, Yang Q, Liu Y, Zhou S, Jiang J, Reiter R, et al. The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radic Biol Med. 2019;130:215-233 pubmed publisher
    ..We analyze the involvement of melatonin receptor 1A (MT1), melatonin receptor 1B (MT2), and melatonin receptor 1C (MT3) in the protection of melatonin and/or NAS...
  9. Yoon J, Lee Y, Lee S, Kang D, Lee H. Oryeongsan suppressed high glucose-induced mesangial fibrosis. BMC Complement Altern Med. 2015;15:30 pubmed publisher
    ..Oryeongsan increased HG-inhibited membrane type-1 matrix metalloproteinase expression (MT1-MMP) and MMP-2 promotor activity, whereas suppressed HG-induced tissue inhibitor of matrix metalloproteinase-2 (..

More Information

Publications142 found, 100 shown here

  1. Ghosh S, Singh A, Haldar C. Seasonal modulation of immunity by melatonin and gonadal steroids in a short day breeder goat Capra hircus. Theriogenology. 2014;82:1121-30 pubmed publisher
    ..To support and establish the modulation by hormones, Western blot analysis for expressions of melatonin receptors (MT1, MT2), androgen receptor, and estrogen receptor α and estimations of marker enzymes, arylalkylamine N-..
  2. Solov eva N, Timoshenko O, Kugaevskaia E, Andreeva I, Zavalishina L. [Key enzymes of degradation and angiogenesis as a factors of tumor progression in squamous cell carcinoma of the cervix]. Bioorg Khim. 2014;40:743-51 pubmed
    ..Matrix metalloproteases (MMPs) play a leading role during tissue degradation. Tissue collagenase--MMP-1 and MT1-MMP hydrolyze fibrillar collagens, which are the basis of connective tissue matrix, and ensure the development of ..
  3. Kaneko K, Williams R, Dransfield D, Nixon A, Sandison A, Itoh Y. Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade. Arthritis Rheumatol. 2016;68:521-31 pubmed publisher
    ..purpose of this study was to investigate the therapeutic potential of selective inhibition of membrane type 1 MMP (MT1-MMP) and its combination with tumor necrosis factor (TNF) blockage in mice with collagen-induced arthritis (CIA)...
  4. Stauch B, Johansson L, McCorvy J, Patel N, Han G, Huang X, et al. Structural basis of ligand recognition at the human MT1 melatonin receptor. Nature. 2019;: pubmed publisher
  5. Zhou J, Zhang J, Luo X, Li M, Yue Y, Laudon M, et al. Neu-P11, a novel MT1/MT2 agonist, reverses diabetes by suppressing the hypothalamic-pituitary-adrenal axis in rats. Eur J Pharmacol. 2017;812:225-233 pubmed publisher
    ..The objective of the present study was to investigate the effect of the MT1/MT2 melatonin agonist Neu-P11 on glucose and lipid metabolism in T2DM rats induced by a high fat diet combined with ..
  6. Kozela E, Juknat A, Gao F, Kaushansky N, Coppola G, Vogel Z. Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. J Neuroinflammation. 2016;13:136 pubmed publisher
    ..of oxidative stress modulators with potent anti-inflammatory activity that are controlled by Nfe2l2/Nrf2 (Mt1, Mt2a, Slc30a1, Hmox1)...
  7. Biswal M, Ahmed C, ILDEFONSO C, Han P, Li H, Jivanji H, et al. Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress. Exp Eye Res. 2015;140:94-105 pubmed publisher
    ..In mice treated with 8-OH-DPAT, the same genes (MT1, HO1, NqO1, Cat, Sod1) were induced in the neural retina, but the drug did not affect the expression of Sod2, the ..
  8. Shigemura T, Shiohara M, Kato M, Furuta S, Kaneda K, Morishita K, et al. Superoxide-Generating Nox5α Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype. J Virol. 2015;89:9080-9 pubmed publisher
    ..kinase (Jak)-STAT5 signaling pathway in interleukin-2 (IL-2)-independent HTLV-1-transformed cell lines, including MT1 and MT2, whereas it was transiently induced by the IL-2-triggered Jak-STAT5 axis in uninfected T cells...
  9. Zhou J, Wang D, Luo X, Jia X, Li M, Laudon M, et al. Melatonin Receptor Agonist Piromelatine Ameliorates Impaired Glucose Metabolism in Chronically Stressed Rats Fed a High-Fat Diet. J Pharmacol Exp Ther. 2018;364:55-69 pubmed publisher
    ..Piromelatine is a melatonin receptor-1/melatonin receptor-2 (MT1/MT2) agonist with high affinity for MLT receptors and a longer duration of action than MLT...
  10. Wang J, Jiang C, Zhang K, Lan X, Chen X, Zang W, et al. Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway. Free Radic Biol Med. 2019;131:345-355 pubmed publisher
    ..In this study, using a weight-drop model of TBI, we investigated the protective effects of ramelteon, a melatonin MT1/MT2 receptor agonist, and its underlying mechanisms of action...
  11. Song C, Zhao J, Fu B, Li D, Mao T, Peng W, et al. Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1? signaling pathway. Free Radic Biol Med. 2017;112:616-630 pubmed publisher
    ..Our findings provided a theoretical basis that melatonin mitigated NaF-induced hepatotoxicity, which, in part, was mediated through the activation of the Sirt3 pathway. ..
  12. Koeppen A, Kuntzsch E, Bjork S, Ramirez R, Mazurkiewicz J, Feustel P. Friedreich ataxia: metal dysmetabolism in dorsal root ganglia. Acta Neuropathol Commun. 2013;1:26 pubmed publisher
    ..In contrast, MT1/2 immunofluorescence was prominent in proliferating satellite cells...
  13. Arslan H, Özdemir S, Altun S. Cypermethrin toxication leads to histopathological lesions and induces inflammation and apoptosis in common carp (Cyprinus carpio L.). Chemosphere. 2017;180:491-499 pubmed publisher
    ..Thereafter, we identified the expressions of caspase 3, capsase 8, iNOS, and metallothionein 1 (MT1) genes in common carp using quantitative reverse transcription polymerase chain reaction (qRT-PCR)...
  14. Chamanara M, Rashidian A, Mehr S, Dehpour A, Shirkohi R, Akbarian R, et al. Melatonin ameliorates TNBS-induced colitis in rats through the melatonin receptors: involvement of TLR4/MyD88/NF-κB signalling pathway. Inflammopharmacology. 2019;27:361-371 pubmed publisher
    ..Melatonin was administered intraperitoneally (i.p.) at doses of 1, 5, and 10 mg/kg/day. Luzindole (non-selective MT1/MT2 receptor antagonist) was administered i.p. at dose of 5 mg/kg/day 15 min prior to melatonin injection...
  15. Howard C, Lutterschmidt D. The Effects of Melatonin on Brain Arginine Vasotocin: Relationship with Sex and Seasonal Differences in Melatonin Receptor Type 1 in Green Treefrogs (Hyla cinerea). J Neuroendocrinol. 2015;27:670-9 pubmed publisher
    ..tested this hypothesis by using immunohistochemistry to characterise the distribution of melatonin receptor type 1 (MT1, also known as Mel1a) in the brain of reproductive and nonreproductive male and female frogs...
  16. Scudiero R, Cigliano L, Verderame M. Age-related changes of metallothionein 1/2 and metallothionein 3 expression in rat brain. C R Biol. 2017;340:13-17 pubmed publisher
    ..By using real-time PCR analysis, we determined the MT1/2 and MT3 expression profiles in cerebral cortex and hippocampus of adolescent (2months), adult (4 and 8months), ..
  17. Zhang S, Liu H, Amarsingh G, Cheung C, Hogl S, Narayanan U, et al. Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation. Cardiovasc Diabetol. 2014;13:100 pubmed publisher
    ..expression and increased polymerization of the copper-responsive transition-metal-binding metallothionein proteins (MT1/MT2), consistent with impaired anti-oxidant defences and elevated susceptibility to pro-oxidant stress...
  18. Xie L, Collins J. Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia. J Biol Chem. 2013;288:23943-52 pubmed publisher
    ..g. Dmt1 and Dcytb) and copper (e.g. Atp7a and Mt1) metabolism-related proteins...
  19. Leeboonngam T, Pramong R, Sae ung K, Govitrapong P, Phansuwan Pujito P. Neuroprotective effects of melatonin on amphetamine-induced dopaminergic fiber degeneration in the hippocampus of postnatal rats. J Pineal Res. 2017;: pubmed publisher
    ..signaling molecule, calcium/calmodulin-dependent protein kinase II (CaMKII), and the melatonin receptors (MT1 and MT2)...
  20. Comai S, López Canul M, De Gregorio D, Posner A, Ettaoussi M, Guarnieri F, et al. Melatonin MT1 receptor as a novel target in neuropsychopharmacology: MT1 ligands, pathophysiological and therapeutic implications and perspectives. Pharmacol Res. 2019;: pubmed publisher
    ..Consequently, this MLT receptor subtype deserves to be further examined as a novel target for neuropsychopharmacological drug development. ..
  21. Dominguez G, Lohse S, Torelli M, Murphy C, Hamers R, Orr G, et al. Effects of charge and surface ligand properties of nanoparticles on oxidative stress and gene expression within the gut of Daphnia magna. Aquat Toxicol. 2015;162:1-9 pubmed publisher
    ..stress: glutathione S-transferase (gst), catalase (cat), heat shock protein 70 (hsp70), and metallothionein1 (mt1). We found ROS formation and gene expression were impacted by both charge and the specific surface ligand used...
  22. Nakazato K, Tomioka S, Nakajima K, Saito H, Kato M, Kodaira T, et al. Determination of the serum metallothionein (MT)1/2 concentration in patients with Wilson's disease and Menkes disease. J Trace Elem Med Biol. 2014;28:441-7 pubmed publisher
    ..The reactivity of this ELISA system with the liver, kidney and brain in MT1/2 knock-out mice was significantly low, but was normal in an MT-3 knock-out mouse...
  23. Sakamuri S, Takawale A, Basu R, Fedak P, Freed D, Sergi C, et al. Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure. Transl Res. 2016;172:30-44 pubmed publisher
    ..Matrix metalloproteinases (MMP1, MMP2, MMP8, MMP13, and MT1-MMP/MMP14) were comparable between DCM hearts...
  24. Kadota Y, Toriuchi Y, Aki Y, Mizuno Y, Kawakami T, Nakaya T, et al. Metallothioneins regulate the adipogenic differentiation of 3T3-L1 cells via the insulin signaling pathway. PLoS ONE. 2017;12:e0176070 pubmed publisher
    ..We evaluated the fat pads of mice during the lactation stage. The fat mass and adipocyte size of MT1 and MT2 knockout mice were greater than those of wild type mice...
  25. Yang W, Tang K, Wang Y, Zhang Y, Zan L. Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes. Sci Rep. 2017;7:15080 pubmed publisher
    ..and redox status were reversed by treatment with luzindole, anantagonist of nonspecific melatonin receptors 1 (MT1) and 2 (MT2), and 4-phenyl-2-propionamidotetraline (4P-PDOT), a selective MT2 antagonist...
  26. Nishihara T, Remacle A, Angert M, Shubayev I, Shiryaev S, Liu H, et al. Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury. J Biol Chem. 2015;290:3693-707 pubmed publisher
    ..or jointly, depended on the pericellular remodeling events executed by membrane-type 1 matrix metalloproteinase (MT1-MMP/MMP-14)...
  27. Fisker K, Holmstrup M, Sørensen J. Freezing of body fluids induces metallothionein gene expression in earthworms (Dendrobaena octaedra). Comp Biochem Physiol C Toxicol Pharmacol. 2016;179:44-8 pubmed publisher
    ..and copper would induce transcription of genes coding for heat shock proteins (hsp10 and hsp70), metallothioneins (mt1 and mt2), and glutathione-S-transferase (gst), and that the combined effects of these two stressors would be ..
  28. Lam C, Jamerson M, Cabral G, Carlesso A, Marciano Cabral F. Expression of matrix metalloproteinases in Naegleria fowleri and their role in invasion of the central nervous system. Microbiology. 2017;163:1436-1444 pubmed publisher
    ..metalloproteinases MMP-2 (gelatinase A), MMP-9 (gelatinase B) and MMP-14 [membrane type-1 matrix metalloproteinase (MT1-MMP)]...
  29. Read S, Parnell G, Booth D, Douglas M, George J, Ahlenstiel G. The Antiviral Role of Zinc and Metallothioneins in Hepatitis C Infection. J Viral Hepat. 2017;: pubmed publisher
    ..Using a pan-metallothionein siRNA to knock down all members of the MT1 and 2 subfamilies we demonstrate that they are mildly antiviral against the JFH1 strain of HCV in vitro (~1...
  30. Wang C, Li Z, Shao F, Yang X, Feng X, Shi S, et al. High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation. J Exp Clin Cancer Res. 2017;36:84 pubmed publisher
    ..FRA-1 also induced snail1-mediated MMP14 (matrix metallopeptidase 14, also known as MT1-MMP) expression to facilitate ESCC cell invasion, migration, and metastasis...
  31. Gallardo Vara E, Blanco F, Roqué M, Friedman S, Suzuki T, Botella L, et al. Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury. Angiogenesis. 2016;19:155-71 pubmed publisher
    ..The membrane metalloproteinase 14 (MMP14 or MT1-MMP) targets endoglin to release soluble endoglin and is involved in vascular inflammation and endothelial ..
  32. Altun S, Özdemir S, Arslan H. Histopathological effects, responses of oxidative stress, inflammation, apoptosis biomarkers and alteration of gene expressions related to apoptosis, oxidative stress, and reproductive system in chlorpyrifos-exposed common carp (Cyprinus carpio L.). Environ Pollut. 2017;230:432-443 pubmed publisher
    ..Additionally, we measured the expression levels of caspase-3, caspase-8, iNOS, MT1, CYP1A, and CYP3A genes in chlorpyrifos-exposed brain tissue, as well as the expression levels of FSH and LH genes ..
  33. Gupta S, Singh P, Sharma B, Sharma B. Neuroprotective Effects of Agomelatine and Vinpocetine Against Chronic Cerebral Hypoperfusion Induced Vascular Dementia. Curr Neurovasc Res. 2015;12:240-52 pubmed
    ..Aim of this study is to explore the role of agomelatine (a dual MT1 and MT2 melatonin receptor agonist) and vinpocetine (selective PDE1 inhibitor) in CCH induced vascular dementia (..
  34. Cui Y, Wang J, Zhang X, Bi M, Guo L, Lu S. Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. World J Gastroenterol. 2003;9:1892-6 pubmed
    ..A further understanding of the association between ECRG2 and MT should facilitate the functions of ECRG2 gene. ..
  35. Tu C, Zhou J, Yuan L. Letter regarding "MT1-MMP is not a good prognosticator of cancer survival: evidence from 11 studies" by Wu KP et al. Tumour Biol. 2016;37:5761-3 pubmed publisher
    With great interest, we carefully read a meta-analysis entitled "MT1-MMP is not a good prognosticator of cancer survival: evidence from 11 studies" in Tumor Biology (by Wu KP et al...
  36. Cardinali D, Golombek D, Rosenstein R, Brusco L, Vigo D. Assessing the efficacy of melatonin to curtail benzodiazepine/Z drug abuse. Pharmacol Res. 2016;109:12-23 pubmed publisher
    ..This action is attributed to MT1 and MT2 melatoninergic receptors localized in the SCN, as well as in other brain areas...
  37. Duan Q, Wang T, Zhang N, Perera V, Liang X, Abeysekera I, et al. Propylthiouracil, Perchlorate, and Thyroid-Stimulating Hormone Modulate High Concentrations of Iodide Instigated Mitochondrial Superoxide Production in the Thyroids of Metallothionein I/II Knockout Mice. Endocrinol Metab (Seoul). 2016;31:174-84 pubmed publisher
    ..Eight-week-old 129S7/SvEvBrd-Mt1(tm1Bri) Mt2(tm1Bri)/J (MT-I/II KO) mice and background-matched wild type (WT) mice were used...
  38. Tchekalarova J, Nenchovska Z, Atanasova D, Atanasova M, Kortenska L, Stefanova M, et al. Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats. Behav Brain Res. 2016;302:11-28 pubmed publisher
    ..The aim of the present study was to determine whether the antidepressant drug agomelatine, a MT1/MT2 melatoninergic receptor agonist/5-HT2C receptor antagonist is able to prevent some of the behavioral, ..
  39. Jiang B, Zhang Y, Liu J, Tsigkou A, Rapti M, Lee M. Ensnaring membrane type 1-matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase (TIMP)-2 using the haemopexin domain of the protease as a carrier: a targeted approach in cancer inhibition. Oncotarget. 2017;8:22685-22699 pubmed publisher
    Metastatic cancer cells express Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) to degrade the extracellular matrix in order to facilitate migration and proliferation...
  40. Huet E, Gabison E, Vallee B, Mougenot N, Linguet G, Riou B, et al. Deletion of extracellular matrix metalloproteinase inducer/CD147 induces altered cardiac extracellular matrix remodeling in aging mice. J Physiol Pharmacol. 2015;66:355-66 pubmed
    ..the 12 month old KO mice which paralleled with a greater reduction in the TGF-β known activating enzymes such as MT1-MMP and MMP-1 (33% and 37% reduction respectively, between 3 and 12 month old in KO mice; P < 0...
  41. Radhika V, Ueda N, Tsuboi Y, Kojima M, Kikuchi J, Kudo T, et al. Methylated Cytokinins from the Phytopathogen Rhodococcus fascians Mimic Plant Hormone Activity. Plant Physiol. 2015;169:1118-26 pubmed publisher
    ..MeCKs were synthesized by S-adenosyl methionine-dependent methyltransferases (MT1 and MT2) that are present upstream of the fas genes. The best substrate for methylation was isopentenyl diphosphate...
  42. Hu J, Zhang X, Zhang Y, Zhao X, Li F, Tao J. Molecular characterization and expression profile of the melatonin receptor MT1 in the ovary of Tianzhu white yak (Bos grunniens). Gen Comp Endocrinol. 2017;242:101-107 pubmed publisher
    ..In the present study, the melatonin receptor MT1 was cloned by RT-PCR in the ovary of white yak; the MT1 cDNA fragment obtained (843bp) comprised an open reading ..
  43. Tao J, Lv J, Li W, Zhang P, Mao C, Xu Z. Exogenous melatonin reduced blood pressure in late-term ovine fetus via MT1/MT2 receptor pathways. Reprod Biol. 2016;16:212-217 pubmed publisher
    ..Plasma level of endothelin was decreased by melatonin, which was blocked by luzindole. Our study suggested that melatonin reduced fetal blood pressure via MT1/MT2 receptors and possibly involving release of endothelin.
  44. Durkalec M, Kolenda R, Owczarek T, Szkoda J, Nawrocka A, Grzegrzółka J, et al. Expression of metallothionein in the liver and kidneys of the red deer (Cervus elaphus L.) from an industrial metal smelting area of Poland. Ecotoxicol Environ Saf. 2017;137:121-129 pubmed publisher
    The metallothionein 1 (MT1) coding sequence of red deer was identified and compared to orthologous sequences from other mammals. Over 90% identity was observed between red deer MT1 amino acid sequence and MT1 sequences of other ruminants...
  45. Jumnongprakhon P, Sivasinprasasn S, Govitrapong P, Tocharus C, Tocharus J. Activation of melatonin receptor (MT1/2) promotes P-gp transporter in methamphetamine-induced toxicity on primary rat brain microvascular endothelial cells. Toxicol In Vitro. 2017;41:42-48 pubmed publisher
    ..Previous studies have reported that the activation of melatonin receptors (MT1/2) by melatonin could protect against METH-induced toxicity in brain endothelial cells via several mechanisms...
  46. Sampels S, Kroupova H, Linhartova P. Effect of cadmium on uptake of iron, zinc and copper and mRNA expression of metallothioneins in HepG2 cells in vitro. Toxicol In Vitro. 2017;44:372-376 pubmed publisher
    ..In addition mRNA expression of two metallothioneins (mt1 g and mt1 m) was evaluated by real-time PCR...
  47. Hevia D, González Menéndez P, Fernandez Fernandez M, Cueto S, Rodriguez Gonzalez P, García Alonso J, et al. Melatonin Decreases Glucose Metabolism in Prostate Cancer Cells: A 13C Stable Isotope-Resolved Metabolomic Study. Int J Mol Sci. 2017;18: pubmed publisher
    ..Some of them are exerted through its specific membrane receptors type 1 and type 2 (MT1 and MT2) while others are mediated by receptor-independent mechanisms...
  48. Xu H, Snider T, Wimer H, Yamada S, Yang T, Holmbeck K, et al. Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption. Matrix Biol. 2016;52-54:266-283 pubmed publisher
    Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a transmembrane zinc-endopeptidase that breaks down extracellular matrix components, including several collagens, during tissue development and physiological remodeling...
  49. Couhert A, Delagrange P, Caignard D, Chartier A, Suzenet F, Guillaumet G. Synthesis of 2-arylfuro[3,2-b]pyridines: Effect of the C2-aryl group on melatoninergic activity. Eur J Med Chem. 2016;109:268-75 pubmed publisher
    ..Introduction of 1-naphthyl substituent gave the best result in terms of selectivity with a MT1/MT2 ratio of about 150 (MT1 Ki = 198 nM, MT2 Ki = 1.3 nM).
  50. Norden P, Kim D, Barry D, CLEAVER O, Davis G. Cdc42 and k-Ras Control Endothelial Tubulogenesis through Apical Membrane and Cytoskeletal Polarization: Novel Stimulatory Roles for GTPase Effectors, the Small GTPases, Rac2 and Rap1b, and Inhibitory Influence of Arhgap31 and Rasa1. PLoS ONE. 2016;11:e0147758 pubmed publisher
    ..the role of Cdc42 and Rac1 and their effectors such as Pak2, Pak4, Par6b, and co-regulators such as integrins, MT1-MMP and Par3; many key questions remain that are necessary to elucidate molecular and signaling requirements for ..
  51. Yang X, Zou D, Tang S, Fan T, Su H, Hu R, et al. Ameliorative effect of melatonin against increased intestinal permeability in diabetic rats: possible involvement of MLCK-dependent MLC phosphorylation. Mol Cell Biochem. 2016;416:23-32 pubmed publisher
    ..They were partly associated with down-regulated membrane type 1 and 2 (MT1 and MT2) expression, and up-regulated Rho-associated protein kinase (ROCK) expression and increased extracellular ..
  52. Lagoutte E, Villeneuve C, Lafanechere L, Wells C, Jones G, Chavrier P, et al. LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP. Sci Rep. 2016;6:24925 pubmed publisher
    ..Dissemination of breast carcinoma cells is mediated by membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14), the main invadopodial matrix degradative component...
  53. Chumboatong W, Thummayot S, Govitrapong P, Tocharus C, Jittiwat J, Tocharus J. Neuroprotection of agomelatine against cerebral ischemia/reperfusion injury through an antiapoptotic pathway in rat. Neurochem Int. 2017;102:114-122 pubmed publisher
    Agomelatine is an agonist of the melatonergic MT1/MT2 receptors and an antagonist of the serotonergic 5-HT receptors. Its actions mimic melatonin in antioxidative and anti-inflammation...
  54. Bao H, Jiang M, Zhu M, Sheng F, Ruan J, Ruan C. Overexpression of Annexin II affects the proliferation, apoptosis, invasion and production of proangiogenic factors in multiple myeloma. Int J Hematol. 2009;90:177-185 pubmed publisher
    ..gene by siRNA also inhibited the expression of pro-angiogenic molecules including VEGF-C, VEGF-R2, MMP-2, MMP-9, MT1-MMP and TIMP-2 in the two cell lines...
  55. Shah C, Kablinger A. Ramelteon-induced nightmares: A case report. Asian J Psychiatr. 2015;18:111-2 pubmed publisher
    Ramelteon is the only FDA-approved melatonin agonist for treatment of insomnia. It acts on melatonin MT1 and MT2 receptors. We describe a case of a patient who was prescribed ramelteon for insomnia disorder...
  56. Benleulmi Chaachoua A, Chen L, Sokolina K, Wong V, Jurisica I, Emerit M, et al. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. J Pineal Res. 2016;60:95-108 pubmed publisher
    ..Its peripheral and central actions rely either on its intrinsic antioxidant properties or on binding to melatonin MT1 and MT2 receptors, belonging to the G protein-coupled receptor (GPCR) super-family...
  57. Botkjaer K, Kwok H, Terp M, Karatt Vellatt A, Santamaria S, McCafferty J, et al. Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo. Oncotarget. 2016;7:16773-92 pubmed publisher
    The membrane-associated matrix metalloproteinase-14, MT1-MMP, has been implicated in pericellular proteolysis with an important role in cellular invasion of collagenous tissues...
  58. Gucciardo E, Mobashir M, Lehti K. Proactive for invasion: Reuse of matrix metalloproteinase for structural memory. J Cell Biol. 2016;213:11-3 pubmed publisher
    Migratory cells translocate membrane type-1 matrix metalloproteinase (MT1-MMP) to podosomes or invadosomes to break extracellular matrix barriers. In this issue, El Azzouzi et al. (2016.J. Cell. Biol.http://dx.doi.org/10.1083/jcb...
  59. Fischer C, Mueller T, Pfeffer M, Wicht H, Von Gall C, Korf H. Melatonin Receptor 1 Deficiency Affects Feeding Dynamics and Pro-Opiomelanocortin Expression in the Arcuate Nucleus and Pituitary of Mice. Neuroendocrinology. 2017;105:35-43 pubmed publisher
    ..mediates photoperiod-dependent changes in physiology and behavior by targeting specific membrane-bound receptors (MT1 and MT2)...
  60. Cisse Y, Russart K, Nelson R. Depressive-like behavior is elevated among offspring of parents exposed to dim light at night prior to mating. Psychoneuroendocrinology. 2017;83:182-186 pubmed publisher
    ..tested in adulthood for depressive-like behaviors and hippocampal expression of glucocorticoid (GR) and melatonin (MT1) receptor expression...
  61. van Duijnhoven S, Robillard M, Nicolay K, Grüll H. Development of Radiolabeled Membrane Type-1 Matrix Metalloproteinase Activatable Cell Penetrating Peptide Imaging Probes. Molecules. 2015;20:12076-92 pubmed publisher
    Membrane type-1 matrix metalloproteinase (MT1-MMP or MMP-14) plays an important role in adverse cardiac remodelling...
  62. Li Y, Zhou C, Gao Y. Moesin regulates the motility of oral cancer cells via MT1-MMP and E-cadherin/p120-catenin adhesion complex. Oral Oncol. 2015;51:935-43 pubmed publisher
    ..and western blotting were used to investigate the expression of Moesin, E-cadherin, p120-catenin and MT1-MMP in normal epithelia, dysplasia and OSCCs...
  63. Wang H, Wang Y, Bo Q, Ji Y, Liu L, Hu Y, et al. Maternal cadmium exposure reduces placental zinc transport and induces fetal growth restriction in mice. Reprod Toxicol. 2016;63:174-82 pubmed publisher
    ..As expected, fetal weight and crown-rump length were reduced in a gender-independent manner. Interestingly, Mt1 and Mt2, two metallothionein genes, were up-regulated in maternal liver...
  64. Klimentova J, CEBOVA M, Barta A, Matuskova Z, Vrankova S, Rehakova R, et al. Effect of melatonin on blood pressure and nitric oxide generation in rats with metabolic syndrome. Physiol Res. 2016;65:S373-S380 pubmed
    ..Interestingly, melatonin elevated MT1 protein expression in the cerebellum. Neuronal NOS protein expression was not changed within the groups...
  65. Ferrer D, Dato V, Jaldin Fincati J, Lorenc V, Sanchez M, Chiabrando G. Activated ?2 -Macroglobulin Induces Mesenchymal Cellular Migration Of Raw264.7 Cells Through Low-Density Lipoprotein Receptor-Related Protein 1. J Cell Biochem. 2017;118:1810-1818 pubmed publisher
    ..This migration exhibits the production of enlarged cellular protrusions, MT1-MMP distribution to these leading edge protrusions, actin polymerization, focal adhesion formation, and increased ..
  66. Cheng Z, Liu L, Wang Z, Cai Y, Xu Q, Chen P. Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis. Int J Mol Sci. 2018;19: pubmed publisher
    ..protein with kazal motifs) and TIMP-2 (tissue inhibitor of metalloproteinase-2), while the protein level of MT1-MMP (membrane type 1-matrix metalloproteinase) increased and MMP-2 activity was enhanced...
  67. Gutierrez Urrutia I, Miossec M, Valenzuela S, Meneses C, dos Santos V, Castro Nallar E, et al. Genome sequence of two members of the chloroaromatic-degrading MT community: Pseudomonas reinekei MT1 and Achromobacter xylosoxidans MT3. J Biotechnol. 2018;275:13-16 pubmed publisher
    We describe the genome sequence of Pseudomonas reinekei MT1 and Achromobacter xylosoxidans MT3, the most abundant members of a bacterial community capable of degrading chloroaromatic compounds...
  68. Engelholm L, Melander M, Hald A, Persson M, Madsen D, Jürgensen H, et al. Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180. J Pathol. 2016;238:120-33 pubmed publisher
    ..specimens showed strong expression of this receptor on tumour cells, along with the collagenolytic metalloprotease, MT1-MMP...
  69. Chabasse C, Siefert S, Chaudry M, Hoofnagle M, Lal B, Sarkar R. Recanalization and flow regulate venous thrombus resolution and matrix metalloproteinase expression in vivo. J Vasc Surg Venous Lymphat Disord. 2015;3:64-74 pubmed publisher
    ..006, respectively) as well as a difference in MT2-MMP gene expression at day 8 (P = .044) and day 12 (P = .03) and MT1-MMP protein expression at day 4 (P = .021)...
  70. Rice J, Zweifach A, Lynes M. Metallothionein regulates intracellular zinc signaling during CD4(+) T cell activation. BMC Immunol. 2016;17:13 pubmed publisher
    ..When Tr1 cells from wildtype mice are compared with congenic mice lacking functional Mt1 and Mt2 genes, the expression of intracellular MT is associated with a greater increase in intracellular [Zn(2+)] ..
  71. Morgan B, D Mello S. The influence of positive vs. negative affect on multitasking. Acta Psychol (Amst). 2016;170:10-8 pubmed publisher
    ..Participants multitasked for a 3-min baseline phase (MT1), following which they were randomly assigned to watch one of three affect-induction videos: positive, neutral, or ..
  72. Lin Q, Geng J, Ma K, Yu J, Sun J, Shen Z, et al. RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China. J Cancer Res Clin Oncol. 2009;135:1675-84 pubmed publisher
    ..The methylated state of p16INK4A, ESR1, HOX9, RASSF1A, DAPK1, PTEN, ABCB1, MGMT, APC and MT1G genes that have been reported frequently methylated in lung cancer was determined using methylation-specific PCR in ..
  73. Emeny R, Kasten Jolly J, Mondal T, Lynes M, Lawrence D. Metallothionein differentially affects the host response to Listeria infection both with and without an additional stress from cold-restraint. Cell Stress Chaperones. 2015;20:1013-22 pubmed publisher
    ..anti-bacterial responses that occur during stress, using a C57BL/6 (B6) strain that has targeted disruptions of the Mt1 and Mt2 genes (B6-MTKO), and a B6 strain that has additional copies of Mt (B6-MTTGN)...
  74. Wongprayoon P, Govitrapong P. Melatonin attenuates methamphetamine-induced neuroinflammation through the melatonin receptor in the SH-SY5Y cell line. Neurotoxicology. 2015;50:122-30 pubmed publisher
    ..This attenuating effect was prevented by pre-incubation with luzindole, an antagonist of the melatonin MT1/MT2 receptors...
  75. Redelstein R, Zielke H, Spira D, Feiler U, Erdinger L, Zimmer H, et al. Bioaccumulation and molecular effects of sediment-bound metals in zebrafish embryos. Environ Sci Pollut Res Int. 2015;22:16290-304 pubmed publisher
    ..Furthermore, transcript abundances of the metallothioneins MT1 and MT2, the metal-responsive element-binding transcription factor (MTF) and the genes sod1, hsp70 and hsp90α1 ..
  76. Kim D, Jung J, You E, Ko P, Oh S, Rhee S. mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization. Oncotarget. 2016;7:17829-43 pubmed publisher
    ..reduced invasive activity by controlling cellular localization of membrane type 1-matrix metalloproteinase (MT1-MMP) through interaction with microtubule tracks...
  77. Lee M, Ryu C, Chang H, Kim G, Kim S, Kim S. Radiotherapy-associated Furin Expression and Tumor Invasiveness in Recurrent Laryngeal Cancer. Anticancer Res. 2016;36:5117-5125 pubmed
    ..furin expression with up-regulated expression of the active form of membrane type 1-matrix metalloproteinase (MT1-MMP)/MMP-2, whereas AMC-HN-8-70Gy cells did not show significant changes...
  78. Verhelle A, Van Overbeke W, Peleman C, De Smet R, Zwaenepoel O, Lahoutte T, et al. Non-Invasive Imaging of Amyloid Deposits in a Mouse Model of AGel Using 99mTc-Modified Nanobodies and SPECT/CT. Mol Imaging Biol. 2016;18:887-897 pubmed
    ..This C68 fragment is cleaved by membrane type 1-matrix metalloproteinase (MT1-MMP) during secretion into the extracellular environment, releasing 8- and 5-kDa amyloidogenic peptides...
  79. Li R, Hebert J, Lee T, Xing H, Boussommier Calleja A, Hynes R, et al. Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways. Cancer Res. 2017;77:279-290 pubmed publisher
    ..In contrast, macrophage-released TGFβ1 enhanced migration speed primarily by inducing MT1-MMP expression...
  80. Fredrich M, Hampel M, Seidel K, Christ E, Korf H. Impact of melatonin receptor-signaling on Zeitgeber time-dependent changes in cell proliferation and apoptosis in the adult murine hippocampus. Hippocampus. 2017;27:495-506 pubmed publisher
    ..and apoptosis in the adult murine hippocampus and their regulation by melatonin receptor type1 and type2 (MT1/2)-mediated signaling...
  81. Hasan M, Genovese S, Fiorito S, Epifano F, Witt Enderby P. Oxyprenylated Phenylpropanoids Bind to MT1 Melatonin Receptors and Inhibit Breast Cancer Cell Proliferation and Migration. J Nat Prod. 2017;: pubmed publisher
  82. Nakamura M, Zhang X, Mizumoto Y, Maida Y, Bono Y, Takakura M, et al. Molecular characterization of CD133+ cancer stem-like cells in endometrial cancer. Int J Oncol. 2014;44:669-77 pubmed publisher
    ..Matrigel invasion assay revealed that CD133+ cells have enhanced invasive capacity with elevated MT1-MMP expression...
  83. Yang H, Guan L, Li S, Jiang Y, Xiong N, Li L, et al. Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo. Oncotarget. 2016;7:16227-47 pubmed publisher
    ..8 and 4.0 dynes/cm2) to MDA-MB-231 cells significantly increased the cell motility, invadopodia formation, MT1-MMP expression, ECM degradation, and also induced a sustained activation of Cav-1 and PI3K/Akt/mTOR signaling ..
  84. Cepeda M, Pelling J, Evered C, Leong H, Damjanovski S. The cytoplasmic domain of MT1-MMP is dispensable for migration augmentation but necessary to mediate viability of MCF-7 breast cancer cells. Exp Cell Res. 2017;350:169-183 pubmed publisher
    Membrane-type-1 Matrix Metalloproteinase (MT1-MMP) is a multifunctional protease that regulates ECM degradation, proMMP-2 activation, and varied cellular processes including migration and viability...
  85. Osier N, Pham L, Pugh B, Puccio A, Ren D, Conley Y, et al. Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2. Neurosci Lett. 2017;650:18-24 pubmed publisher
    ..The purpose of this study is to explore whether endogenous changes in two melatonin receptor subtypes (MT1 and MT2) occur after experimental TBI...
  86. Braga D, Barcella M, D Avila F, Lupoli S, Tagliaferri F, Santamaria M, et al. Preliminary profiling of blood transcriptome in a rat model of hemorrhagic shock. Exp Biol Med (Maywood). 2017;242:1462-1470 pubmed publisher
    ..of genes related to inflammation and immune response (Tlr13, Il1b, Ccl6, Lgals3), antioxidant functions (Mt2A, Mt1), tissue injury and repair pathways (Gpnmb, Trim72) and lipid mediators (Alox5ap, Ltb4r, Ptger2) compared with ..
  87. Yuan C, Li M, Zheng Y, Zhou Y, Wu F, Wang Z. Accumulation and detoxification dynamics of Chromium and antioxidant responses in juvenile rare minnow, Gobiocypris rarus. Aquat Toxicol. 2017;190:174-180 pubmed publisher
    ..contents of glutathione (GSH) and malonaldehyde (MDA), and transcripts of cat, Cu/Zn-sod, Mn-sod, gpx1, gstpi, gr, mt1, nrf2 and uba52 were determined. The results indicated that G...
  88. Taniguchi M, Matsuura K, Nakamura R, Kojima A, Konishi M, Akizawa T. MMP-7 cleaves amyloid β fragment peptides and copper ion inhibits the degradation. Biometals. 2017;30:797-807 pubmed publisher
    ..both the soluble-type matrix metalloproteinases (MMP-2 and MMP-9) and the membrane-type matrix metalloproteinase (MT1-MMP) are capable of degrading Aβ peptides...
  89. Pariente R, Bejarano I, Espino J, Rodriguez A, Pariente J. Participation of MT3 melatonin receptors in the synergistic effect of melatonin on cytotoxic and apoptotic actions evoked by chemotherapeutics. Cancer Chemother Pharmacol. 2017;80:985-998 pubmed publisher
    ..Blockade of MT1 and/or MT2 receptors with luzindole or 4-P-PDOT was unable to reverse the enhancing effects of melatonin on both ..
  90. Vancura P, Abdelhadi S, Csicsely E, Baba K, Tosini G, Iuvone P, et al. Gnaz couples the circadian and dopaminergic system to G protein-mediated signaling in mouse photoreceptors. PLoS ONE. 2017;12:e0187411 pubmed publisher
    ..the rhythmic release of the neurohormones dopamine-acting on dopamine D4 receptors-and melatonin-acting on MT1 and MT2 receptors...
  91. Sanderson R, Bandari S, Vlodavsky I. Proteases and glycosidases on the surface of exosomes: Newly discovered mechanisms for extracellular remodeling. Matrix Biol. 2019;75-76:160-169 pubmed publisher
    ..Recently, several enzymes including membrane-type 1 matrix metalloproteinase (MT1-MMP), insulin-degrading enzyme (IDE), sialidase and heparanase, among others, were localized on the surface of ..
  92. Ozben T, Hanikoglu A, Kucuksayan E, Akduman R. Effects of Melatonin in Cancer: Potential Mechanisms. Anticancer Agents Med Chem. 2017;: pubmed publisher
    ..Its physiological functions relate principally to the interaction of G protein-coupled MT1 and MT2 trans-membrane receptors (GPCRs), a family of guanidine triphosphate binding proteins...