MST1

Summary

Gene Symbol: MST1
Description: macrophage stimulating 1
Alias: D3F15S2, DNF15S2, HGFL, MSP, NF15S2, hepatocyte growth factor-like protein, hepatocyte growth factor-like protein homolog, macrophage stimulating 1 (hepatocyte growth factor-like), macrophage-stimulating protein
Species: human
Products:     MST1

Top Publications

  1. Karlsen T, Franke A, Melum E, Kaser A, Hov J, Balschun T, et al. Genome-wide association analysis in primary sclerosing cholangitis. Gastroenterology. 2010;138:1102-11 pubmed publisher
    ..We aimed to characterize the genetic susceptibility to primary sclerosing cholangitis (PSC) by means of a genome-wide association analysis of single nucleotide polymorphism (SNP) markers...
  2. Yoshimura T, Yuhki N, Wang M, Skeel A, Leonard E. Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. J Biol Chem. 1993;268:15461-8 pubmed
    A human hepatoma (HepG2) cell line library was screened with an oligonucleotide probe for macrophage stimulating protein (MSP) to clone an MSP cDNA. Deduced sequences of isolated clones were compared with peptide fragment sequences of MSP...
  3. Yuan Z, Lehtinen M, Merlo P, Villen J, Gygi S, Bonni A. Regulation of neuronal cell death by MST1-FOXO1 signaling. J Biol Chem. 2009;284:11285-92 pubmed publisher
    The protein kinase mammalian Sterile 20-like kinase 1 (MST1) plays a critical role in the regulation of cell death...
  4. Marquez A, Cenit M, Nunez C, Mendoza J, Taxonera C, Diaz Rubio M, et al. Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility. Genes Immun. 2009;10:631-5 pubmed publisher
    ..and ulcerative colitis (UC) susceptibility of single nucleotide polymorphisms (SNPs) in 3p21, where BSN (bassoon), MST1 (macrophage stimulating-1) and MST1R (MST1 Receptor) genes map...
  5. Qiao M, Wang Y, Xu X, Lu J, Dong Y, Tao W, et al. Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. Mol Cell. 2010;38:512-23 pubmed publisher
    ..We identified Mst1 as a binding partner that interacts with PHLPPs both in vivo and in vitro...
  6. Park J, Park J, Khoi P, Joo Y, Jung Y. MSP-induced RON activation upregulates uPAR expression and cell invasiveness via MAPK, AP-1 and NF-?B signals in gastric cancer cells. Carcinogenesis. 2011;32:175-81 pubmed publisher
    ..The present study investigated the effect of macrophage-stimulating protein (MSP, the RON ligand) on uPAR expression and the underlying signal pathways in human gastric cancer AGS cells...
  7. Melum E, Franke A, Schramm C, Weismüller T, Gotthardt D, Offner F, et al. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet. 2011;43:17-9 pubmed publisher
    ..We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 × 10?¹? and P = 4.1 × 10??, respectively).
  8. Ganesan R, Kolumam G, Lin S, Xie M, Santell L, Wu T, et al. Proteolytic activation of pro-macrophage-stimulating protein by hepsin. Mol Cancer Res. 2011;9:1175-86 pubmed publisher
    Macrophage-stimulating protein (MSP) is a plasminogen-related growth factor and ligand for the receptor tyrosine kinase RON...
  9. Creasy C, Ambrose D, Chernoff J. The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. J Biol Chem. 1996;271:21049-53 pubmed
    The human serine/threonine protein kinases, Mst1 and Mst2, share considerable homology to Ste20 and p21-activated kinase (Pak) throughout their catalytic domains...

More Information

Publications120 found, 100 shown here

  1. Santoro M, Gaudino G, Marchisio P. The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration. Dev Cell. 2003;5:257-71 pubmed
    ..We show that growth factor macrophage stimulating protein (MSP)- and its receptor Ron-mediated PI3K activation in keratinocytes induces phosphorylation of both ..
  2. Angeloni D, Danilkovitch Miagkova A, Miagkov A, Leonard E, Lerman M. The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation. J Biol Chem. 2004;279:3726-32 pubmed
    ..Macrophage-stimulating protein (MSP) is the RON ligand whose binding to RON causes receptor activation...
  3. Fisher S, Tremelling M, Anderson C, Gwilliam R, Bumpstead S, Prescott N, et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet. 2008;40:710-2 pubmed publisher
    ..show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's ..
  4. Goyette P, Lefebvre C, Ng A, Brant S, Cho J, Duerr R, et al. Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. Mucosal Immunol. 2008;1:131-8 pubmed publisher
    ..We then identified a non-synonymous coding variant (rs3197999, R689C) in the macrophage-stimulating 1 (MST1) gene (P-value 3.62 x 10(-6)) that accounts for the association signal, and shows association with both CD and UC...
  5. Chanda D, Li T, Song K, Kim Y, Sim J, Lee C, et al. Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. J Biol Chem. 2009;284:28510-21 pubmed publisher
    ..In this study, we investigated the effect of HGF and its family member, macrophage-stimulating factor (MSP), on hepatic gluconeogenesis in primary hepatocytes...
  6. Festen E, Stokkers P, van Diemen C, van Bodegraven A, Boezen H, Crusius B, et al. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. Am J Gastroenterol. 2010;105:395-402 pubmed publisher
    ..Genetic models show that multiple risk loci in an individual increase the risk for developing UC. ..
  7. Lee J, Lees C, Prescott N, Anderson C, Phillips A, Wesley E, et al. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet. 2009;41:1330-4 pubmed publisher
    ..The new associations suggest that changes in the integrity of the intestinal epithelial barrier may contribute to the pathogenesis of ulcerative colitis. ..
  8. Gorlatova N, Chao K, Pal L, Araj R, Galkin A, Turko I, et al. Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution. PLoS ONE. 2011;6:e27269 pubmed publisher
    ..The SNP lies in the MST1 gene encoding Macrophage Stimulating Protein (MSP), and results in an R689C amino acid substitution within the ?-chain of MSP (MSP?)...
  9. Srivastava B, Mells G, Cordell H, Muriithi A, Brown M, Ellinghaus E, et al. Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis. Scand J Gastroenterol. 2012;47:820-6 pubmed publisher
    ..The most associated SNPs identified were rs3197999 (3p21 (MST1), p = 1.9 × 10??, OR(A vs G) = 1.28, 95% CI (1.16-1.42)); rs4147359 (10p15 (IL2RA), p = 2...
  10. Xu C, Liu W, Liu C, Wen C, Lu H, Wan F. Mst1 overexpression inhibited the growth of human non-small cell lung cancer in vitro and in vivo. Cancer Gene Ther. 2013;20:453-60 pubmed publisher
    Mammalian STE20-like kinase 1 (Mst1) ubiquitously encodes serine threonine kinase, which is a 59-kDa class II GC kinase that shares 76% identity in amino-acid sequence with MST2, and is the closest mammalian homolog of Drosophila Hippo ..
  11. Ye L, Xiang T, Zhu J, Li D, Shao Q, Peng W, et al. Interferon Consensus Sequence-Binding Protein 8, a Tumor Suppressor, Suppresses Tumor Growth and Invasion of Non-Small Cell Lung Cancer by Interacting with the Wnt/β-Catenin Pathway. Cell Physiol Biochem. 2018;51:961-978 pubmed publisher
    ..IRF8 expression were determined by Q- PCR. MSP and A+T determined promotor methylation...
  12. Hafez M, Al Shabanah O, Al Rejaie S, Al Harbi N, Hassan Z, Alsheikh A, et al. Increased hypermethylation of glutathione S-transferase P1, DNA-binding protein inhibitor, death associated protein kinase and paired box protein-5 genes in triple-negative breast cancer Saudi females. Asian Pac J Cancer Prev. 2015;16:541-9 pubmed
    ..D2 and retinoic acid receptor-β (RARβ1) genes was analyzed by methylation specific polymerase chain reaction (MSP) in 200 archival formalin- fixed paraffin embedded BC tissues divided into 3 groups; benign breast tissues (20), ..
  13. Yang W, Sharma A, Zhang F, Matsuo S, Wang Z, Wang H, et al. Milk fat globule epidermal growth factor-factor 8-derived peptide attenuates organ injury and improves survival in sepsis. Crit Care. 2015;19:375 pubmed publisher
    ..We hypothesized that MFG-E8-derived short peptides (MSP) flanking its RGD motif could provide protection against organ injury in sepsis...
  14. Wang Y, Hao J, Liu X, Wang H, Zeng X, Yang J, et al. The mechanism of apoliprotein A1 down-regulated by Hepatitis B virus. Lipids Health Dis. 2016;15:64 pubmed publisher
    ..of ApoA1 down regulation by HBV, 11 CpG islands in ApoA1 promotor were tested for DNA methylation status by MSP. HepG2.2...
  15. Sannigrahi M, Sharma R, Singh V, Panda N, Rattan V, Khullar M. DNA methylation regulated microRNAs in HPV-16-induced head and neck squamous cell carcinoma (HNSCC). Mol Cell Biochem. 2018;448:321-333 pubmed publisher
    ..Methylation-specific PCR (MSP) and chromatin immunoprecipitation assay (CHIP) were performed to validate their regulation...
  16. Misawa K, Misawa Y, Kondo H, Mochizuki D, Imai A, Fukushima H, et al. Aberrant methylation inactivates somatostatin and somatostatin receptor type 1 in head and neck squamous cell carcinoma. PLoS ONE. 2015;10:e0118588 pubmed publisher
    ..Promoter methylation status was determined by quantitative methylation-specific PCR (Q-MSP) in HNSCC. Methylation was associated with transcription inhibition...
  17. Sato M, Mochizuki H, Goto Koshino Y, Fujiwara Igarashi A, Takahashi M, Fujino Y, et al. Hypermethylation of the death-associated protein kinase CpG island in canine B-cell lymphoid tumors. Vet Immunol Immunopathol. 2014;161:222-31 pubmed publisher
    ..methylation status of the CpG island was examined using bisulfite sequence analysis and methylation-specific PCR (MSP)...
  18. Elbehiry A, Marzouk E, Hamada M, Al Dubaib M, Alyamani E, Moussa I, et al. Application of MALDI-TOF MS fingerprinting as a quick tool for identification and clustering of foodborne pathogens isolated from food products. New Microbiol. 2017;40:269-278 pubmed
    ..The results of main spectra library (MSP) dendrogram showed that the bacterial and fungal isolates matched with 19 and 9 reference strains stored in the ..
  19. Li R, Zhuang A, Ma J, Ji L, Hou X, Chen H, et al. Effect of Jieduquyuziyin prescription-treated rat serum on MeCP2 gene expression in Jurkat T cells. In Vitro Cell Dev Biol Anim. 2018;54:692-704 pubmed publisher
    ..status of the MeCP2 promoter region was detected using bisulfite modification and methylation-specific PCR (MSP). Real-time PCR was used to measure MeCP2 mRNA expression...
  20. Tübel J, Kuntz L, Marthen C, Schmitt A, Wiest I, VON Eisenhart Rothe R, et al. Methylation of the ER-alpha Promoter Is Influenced by its Ligand Estrogen in Osteosarcoma Cells SAOS-2 In Vitro. Anticancer Res. 2016;36:3199-204 pubmed
    ..of each extracted genomic DNA sample was converted with bisulfite and a real-time methylation-specific PCR (rt-MSP) was performed. The estrogen-stimulated SAOS-2 cells showed a significant increase of ER? expression...
  21. Sheikh I, Kaushal D, Chandra D, Kaushal N. Immunogenicity of a plasmid DNA vaccine encoding 42kDa fragment of Plasmodium vivax merozoite surface protein-1. Acta Trop. 2016;162:66-74 pubmed publisher
    ..In the present study, we have constructed a recombinant DNA vaccine encoding 42kDa fragment of P. vivax MSP-1 and studied the immunogenicity of PvMSP-142 DNA vaccine construct in mice...
  22. Rawski M, Kierończyk B, Długosz J, Świątkiewicz S, Józefiak D. Dietary Probiotics Affect Gastrointestinal Microbiota, Histological Structure and Shell Mineralization in Turtles. PLoS ONE. 2016;11:e0147859 pubmed publisher
    ..to four experimental groups: 1st, (CON)--with no additives; 2nd, (SSPA) with Bacillus subtilis PB6; 3rd, (MSP)--with multiple strain probiotic; and 4th, (SSPB) with Bacillus subtilis C-3102...
  23. Zurita J, Denning D, Paz Y Miño A, Solís M, Arias L. Serious fungal infections in Ecuador. Eur J Clin Microbiol Infect Dis. 2017;36:975-981 pubmed publisher
    ..Globocan, and national data [Instituto Nacional de Estadística y Censos (INEC), Ministerio de Salud Pública (MSP), Sociedad de Lucha Contra el Cáncer (SOLCA), Instituto Nacional de Donación y Trasplante de Órganos, ..
  24. Chu C, Chang S, Wang H, Yang S, Lai K, Lee T. Prognostic Values of EPDR1 Hypermethylation and Its Inhibitory Function on Tumor Invasion in Colorectal Cancer. Cancers (Basel). 2018;10: pubmed publisher
    ..Based on quantitative methylation-specific polymerase chain reaction (Q-MSP), EGF, CHST10 and EPDR1 showed higher hypermethylated levels in CRC tissues than those in ..
  25. Majchrzak Celińska A, Kosicka K, Paczkowska J, Główka F, Breborowicz G, Krzyścin M, et al. HSD11B2, RUNX3, and LINE-1 Methylation in Placental DNA of Hypertensive Disorders of Pregnancy Patients. Reprod Sci. 2017;24:1520-1531 pubmed publisher
    ..Methylation-specific polymerase chain reaction (MSP) and pyrosequencing (PSQ) were used to analyze placental DNA methylation...
  26. Jiang Y, Manduchi E, Stoeckert C, Davies P. Arterial endothelial methylome: differential DNA methylation in athero-susceptible disturbed flow regions in vivo. BMC Genomics. 2015;16:506 pubmed publisher
    ..Methylation-specific PCR (MSP) confirmed differential CpG methylation of HOXA genes, the ER stress gene ATF4, inflammatory regulator microRNA-10a ..
  27. Li P, Zhao Z, Xing H, Li W, Zhu X, Cao Y, et al. Plasmodium malariae and Plasmodium ovale infections in the China-Myanmar border area. Malar J. 2016;15:557 pubmed
    ..Parasite populations were evaluated by PCR amplification and sequencing of the MSP-1 genes. Antifolate sensitivity was assessed by sequencing the dhfr-ts and dhps genes from the P. malariae and P...
  28. Farahzadi R, Fathi E, Mesbah Namin S, Zarghami N. Zinc sulfate contributes to promote telomere length extension via increasing telomerase gene expression, telomerase activity and change in the TERT gene promoter CpG island methylation status of human adipose-derived mesenchymal stem cells. PLoS ONE. 2017;12:e0188052 pubmed publisher
    ..of senescent cells were analyzed with quantitative real-time PCR, PCR-ELISA TRAP assay, methylation specific PCR (MSP), and beta-galactosidase (SA-?-gal) staining, respectively...
  29. Kong F, Li Y, Hu E, Wang R, Wang J, Liu J, et al. The Characteristic of S100A7 Induction by the Hippo-YAP Pathway in Cervical and Glossopharyngeal Squamous Cell Carcinoma. PLoS ONE. 2016;11:e0167080 pubmed publisher
    ..YAP, which is validated by activation or inhibition of the Hippo pathway via loss- and/or gain-of- LATS1 and MST1 function. Subsequently, we prove that TEAD1 is required for YAP transcriptional repression of S100A7...
  30. Glasbey J, Sanders A, Bosanquet D, Ruge F, Harding K, Jiang W. Expression of Hepatocyte Growth Factor-Like Protein in Human Wound Tissue and Its Biological Functionality in Human Keratinocytes. Biomedicines. 2015;3:110-123 pubmed publisher
    Hepatocyte growth factor-like protein (HGFl) and its receptor, Recepteur d'Origine Nantais (RON), have been implicated in the development of wound chronicity...
  31. Marcello M, Singaravelu G, Singson A. Fertilization. Adv Exp Med Biol. 2013;757:321-50 pubmed publisher
    ..to help guide the sperm to the site of fertilization, and sperm secrete a protein called major sperm protein (MSP) to trigger oocyte maturation and ovulation...
  32. Barault L, Amatu A, Bleeker F, Moutinho C, Falcomatà C, Fiano V, et al. Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer. Ann Oncol. 2015;26:1994-9 pubmed publisher
    ..Results were compared with two established techniques, methylation-specific PCR (MSP) and Bs-pyrosequencing...
  33. Takahashi H, Kagara N, Tanei T, Naoi Y, Shimoda M, Shimomura A, et al. Correlation of Methylated Circulating Tumor DNA With Response to Neoadjuvant Chemotherapy in Breast Cancer Patients. Clin Breast Cancer. 2017;17:61-69.e3 pubmed publisher
    ..Methylated ctDNA (met-ctDNA) was determined by one-step methylation-specific PCR (OS-MSP) for the promoter region of RASSF1A. The positivity (23...
  34. Kim W, Khan S, Gvozdenovic Jeremic J, Kim Y, Dahlman J, Kim H, et al. Hippo signaling interactions with Wnt/?-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest. 2017;127:137-152 pubmed publisher
    ..Ablation of the mammalian Hippo kinases Mst1 and Mst2 in liver led to rapid HCC formation and activated Yes-associated protein/WW domain containing ..
  35. Li X, Mupondwa E, Tabil L. Technoeconomic analysis of biojet fuel production from camelina at commercial scale: Case of Canadian Prairies. Bioresour Technol. 2018;249:196-205 pubmed publisher
    ..5-675?million?L?annum-1. Under base case scenario, the minimum selling price (MSP) of HRJ was $1.06?L-1 for a biorefinery plant with size of 225?million?L...
  36. Funwei R, Thomas B, Falade C, Ojurongbe O. Extensive diversity in the allelic frequency of Plasmodium falciparum merozoite surface proteins and glutamate-rich protein in rural and urban settings of southwestern Nigeria. Malar J. 2018;17:1 pubmed publisher
    ..In this study, the merozoite surface proteins (msp-1, msp-2) and glutamate-rich protein (glurp) of Plasmodium falciparum collected from two communities representing ..
  37. Janse van Rensburg H, Azad T, Ling M, Hao Y, Snetsinger B, Khanal P, et al. The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1. Cancer Res. 2018;78:1457-1470 pubmed publisher
    ..The upstream kinases of the Hippo pathway, mammalian STE20-like kinase 1 and 2 (MST1/2), and large tumor suppressor 1 and 2 (LATS1/2), suppress PD-L1 expression while TAZ and YAP enhance PD-L1 levels ..
  38. Zhang Y, Yang H, Long Y, Ma Q, Chen R. Plasma Level of Placenta-Derived Macrophage-Stimulating Protein -Chain in Preeclampsia before 20 Weeks of Pregnancy. PLoS ONE. 2016;11:e0161626 pubmed publisher
    This study aimed to investigate the diagnostic value of placenta-derived macrophage-stimulating protein α-chain (MSP-α) before the 20th week of gestation for the early diagnosis of preeclampsia (PE)...
  39. Marí Almirall M, Cosgaya C, Higgins P, Van Assche A, Telli M, Huys G, et al. MALDI-TOF/MS identification of species from the Acinetobacter baumannii (Ab) group revisited: inclusion of the novel A. seifertii and A. dijkshoorniae species. Clin Microbiol Infect. 2017;23:210.e1-210.e9 pubmed publisher
    ..Spectra were examined with the ClinProTools v2.2 software. Mean spectra (MSP) were created with the BioTyper software...
  40. Sarpong K, Bose R. Efficient sortase-mediated N-terminal labeling of TEV protease cleaved recombinant proteins. Anal Biochem. 2017;521:55-58 pubmed publisher
    ..This strategy can be easily applied to any recombinant protein with a TEV site and we demonstrate this on Epidermal Growth Factor Receptor (EGFR) and Membrane Scaffold Protein (MSP) constructs.
  41. Li C, Wang S, Xing Z, Lin A, Liang K, Song J, et al. A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis. Nat Cell Biol. 2017;19:106-119 pubmed publisher
    ..p-HER3 Tyr1307 recruits the LLGL2-MAYA-NSUN6 RNA-protein complex to methylate Hippo/MST1 at Lys59...
  42. Paul G, Deshmukh A, Kumar Chourasia B, Kalamuddin M, Panda A, Kumar Singh S, et al. Protein-protein interaction studies reveal the Plasmodium falciparum merozoite surface protein-1 region involved in a complex formation that binds to human erythrocytes. Biochem J. 2018;475:1197-1209 pubmed publisher
    ..Since MSP-1 complex binds human erythrocytes, we examined the ability of these proteins to bind human erythrocyte...
  43. Luo X, Li Z, Yan Q, Li X, Tao D, Wang J, et al. The human WW45 protein enhances MST1-mediated apoptosis in vivo. Int J Mol Med. 2009;23:357-62 pubmed
    Mammalian sterile 20-like kinase 1 (MST1) is a serine/threonine protein kinase that is activated in response to a variety of apoptotic stimuli and causes apoptosis when over-expressed in mammalian cells...
  44. Perritt K, Herbert R, Levin S, Moline J. Work-related injuries and illnesses reported by World Trade Center response workers and volunteers. Prehosp Disaster Med. 2011;26:401-7 pubmed publisher
    ..and Health (NIOSH), began coordinating the World Trade Center (WTC) Worker and Volunteer Medical Screening Program (MSP) to monitor the health of qualified WTC responders...
  45. Chao K, Gorlatova N, Eisenstein E, Herzberg O. Structural basis for the binding specificity of human Recepteur d'Origine Nantais (RON) receptor tyrosine kinase to macrophage-stimulating protein. J Biol Chem. 2014;289:29948-60 pubmed publisher
    Recepteur d'origine nantais (RON) receptor tyrosine kinase and its ligand, serum macrophage-stimulating protein (MSP), play important roles in inflammation, cell growth, migration, and epithelial to mesenchymal transition during tumor ..
  46. Rampino T, Collesi C, Gregorini M, Maggio M, Soccio G, Guallini P, et al. Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells. J Am Soc Nephrol. 2002;13:649-57 pubmed
    Until now, hepatocytes have been the only known cell source of macrophage-stimulating protein (MSP), and tissue macrophages have been the cells on which the biologic effects of MSP have been proved...
  47. Majchrzak Celińska A, Słocińska M, Barciszewska A, Nowak S, Baer Dubowska W. Wnt pathway antagonists, SFRP1, SFRP2, SOX17, and PPP2R2B, are methylated in gliomas and SFRP1 methylation predicts shorter survival. J Appl Genet. 2016;57:189-97 pubmed publisher
    ..DKK1, SOX17, and DACH1 was analyzed in 64 glioma samples using methylation-specific polymerase chain reaction (MSP). The results were analyzed in correlation with clinicopathological data...
  48. Linnstaedt S, Bortsov A, Soward A, Swor R, Peak D, Jones J, et al. CRHBP polymorphisms predict chronic pain development following motor vehicle collision. Pain. 2016;157:273-9 pubmed publisher
    Musculoskeletal pain (MSP) is a common sequela of traumatic stress exposure...
  49. Geng C, Zhang Y, Gao Y, Tao W, Zhang H, Liu X, et al. Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice. Biochem Biophys Res Commun. 2016;471:444-9 pubmed publisher
    Previous study showed mammalian Ste20-like kinase (Mst1) may serve as target for the development of new therapies for diabetes. However, the function of Mst1 involved in liver lipid metabolism has remained elusive...
  50. Liao T, Tsai C, Jang H, Fushman D, Nussinov R. RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro. Curr Opin Struct Biol. 2016;41:217-224 pubmed publisher
    ..Our mechanistic view explains how RASSF5 can activate MST1/2 and suppress cancer in vivo; but inhibits MST1/2 in vitro...
  51. Pandey R, Pulverer W, Kallmeyer R, Beikircher G, Pabinger S, Kriegner A, et al. MSP-HTPrimer: a high-throughput primer design tool to improve assay design for DNA methylation analysis in epigenetics. Clin Epigenetics. 2016;8:101 pubmed
    ..We have developed a new web-based pipeline, called MSP-HTPrimer, to design primers pairs for MSP, BSP, pyrosequencing, COBRA, and MSRE assays on both genomic strands...
  52. Couzens A, Xiong S, Knight J, Mao D, Guettler S, Picaud S, et al. MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway. Mol Cell Proteomics. 2017;16:1098-1110 pubmed publisher
    ..The core of the pathway consists of a short kinase cascade: MST1 and MST2 phosphorylate and activate LATS1 and LATS2, which in turn phosphorylate and inactivate key transcriptional ..
  53. Zhang M, Lin J, Wang S, Cheng Z, Hu J, Wang T, et al. Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling. J Pineal Res. 2017;63: pubmed publisher
    ..Furthermore, melatonin inhibited Mst1 phosphorylation and promoted Sirt3 expression in DCM...
  54. Meng Z, Moroishi T, Mottier Pavie V, Plouffe S, Hansen C, Hong A, et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015;6:8357 pubmed publisher
    ..Core components of the Hippo pathway include a kinase cascade of MST1/2 and LATS1/2 and the transcription co-activators YAP/TAZ...
  55. Chen X, Chen Y, Dong J. MST2 phosphorylation at serine 385 in mitosis inhibits its tumor suppressing activity. Cell Signal. 2016;28:1826-1832 pubmed publisher
    Mammalian sterile 20-like kinase 1/2 (MST1/2) are core tumor suppressors in the Hippo signaling pathway. MST1/2 have been shown to regulate mitotic progression...
  56. Chung W, Marshall N. Comparative visual ecology of cephalopods from different habitats. Proc Biol Sci. 2016;283: pubmed publisher
    ..Here we introduce a new protocol for photoreceptor microspectrophotometry (MSP) that overcomes the difficulty of bleaching the bistable visual pigment and that reveals eight coastal coleoid ..
  57. Sanyal T, Bhattacharjee S, Bhattacharjee P. Epigenetic alteration of mismatch repair genes in the population chronically exposed to arsenic in West Bengal, India. Environ Res. 2018;163:289-296 pubmed publisher
    ..The methylation status of key MMR genes i.e. MLH1, MSH2, and PMS2 were analyzed using methylation-specific PCR (MSP). The gene expression was studied by qRTPCR...
  58. Reyes M, Rojas Alcayaga G, Pennacchiotti G, Carrillo D, Muñoz J, Peña N, et al. Human papillomavirus infection in oral squamous cell carcinomas from Chilean patients. Exp Mol Pathol. 2015;99:95-9 pubmed publisher
    ..The CDKN2A (p16) promoter methylation was evaluated using methylation-specific PCR (MSP). HPV sequences were found in 9/80 (11%) OSCCs...
  59. Lin Y, Deng Q, Wang Y, Fu X, Ma J, Li W. Aberrant Protocadherin17 (PCDH17) Methylation in Serum is a Potential Predictor for Recurrence of Early-Stage Prostate Cancer Patients After Radical Prostatectomy. Med Sci Monit. 2015;21:3955-690 pubmed
    ..prostate cancer patients and 44 patients with benign prostatic hyperplasia (BPH) using methylation-specific PCR (MSP), and then evaluated the relationship between PCDH17 methylation and clinicopathologic features...
  60. Nohesara S, Ghadirivasfi M, Barati M, Ghasemzadeh M, Narimani S, Mousavi Behbahani Z, et al. Methamphetamine-induced psychosis is associated with DNA hypomethylation and increased expression of AKT1 and key dopaminergic genes. Am J Med Genet B Neuropsychiatr Genet. 2016;171:1180-1189 pubmed publisher
    ..and promoter DNA methylation status of DRD1, DRD2, DRD3, DRD4, MB-COMT, GAD1, and AKT1 using qRT-PCR and q-MSP, respectively...
  61. Guo L, Huang C, Ji Q. Aberrant promoter hypermethylation of p16, survivin, and retinoblastoma in gastric cancer. Bratisl Lek Listy. 2017;118:164-168 pubmed publisher
    ..patients as well as 18 healthy individuals were collected for Methylation-Specific Polymerase Chain Reaction (MSP) analysis. According to the statistical analysis, positive methylation ratio of p16 was 72...
  62. Nematollahi D, Khazalpour S, Ranjbar M, Momeni S. A green strategy for the synthesis of sulfone derivatives of p-methylaminophenol: Kinetic evaluation and antibacterial susceptibility. Sci Rep. 2017;7:4436 pubmed publisher
    ..Various types of mono (MSP), bis (BSP) and tris (TSP) sulfonyl p-methyl aminophenols were obtained by changing the electrode potential, in one ..
  63. Bhutiani N, Egger M, Ajkay N, Scoggins C, Martin R, McMasters K. Multigene Signature Panels and Breast Cancer Therapy: Patterns of Use and Impact on Clinical Decision Making. J Am Coll Surg. 2018;226:406-412.e1 pubmed publisher
    ..This study aimed to evaluate trends in MSP use over time and the effect of MSPs on administration of postoperative chemotherapy...
  64. Rivera M, Echegaray M, Rankinen T, Perusse L, Rice T, Gagnon J, et al. TGF-beta(1) gene-race interactions for resting and exercise blood pressure in the HERITAGE Family Study. J Appl Physiol (1985). 2001;91:1808-13 pubmed
    ..The polymorphism was detected by polymerase chain reaction and digestion with the Msp A1 I endonuclease yielding a wild (leucine-10) and a mutant (proline-10) allele...
  65. Huang R, Chang C, Su P, Chen Y, Liao Y, Wang H, et al. Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms. PLoS ONE. 2012;7:e41060 pubmed publisher
    ..Methylation-specific PCR (MSP), quantitative MSP and bisulfite sequencing were used to verify the methylation status in cancer tissues and ..
  66. Wu F, Lu M, Qu L, Li D, Hu C. DNA methylation of hMLH1 correlates with the clinical response to cisplatin after a surgical resection in Non-small cell lung cancer. Int J Clin Exp Pathol. 2015;8:5457-63 pubmed
    ..Methylation status of hMLH1 was examined by nested methylation-specific PCR (nested MSP) in 84 archived NSCLC surgically resected tissue specimens from patients receiving cisplatin-based adjuvant ..
  67. Jiang L, Li W, Wu M, Cao S. Ciculating miRNA-21 as a Biomarker Predicts Polycystic Ovary Syndrome (PCOS) in Patients. Clin Lab. 2015;61:1009-15 pubmed
    ..In PCOS patients, the expression levels of MST1/2, LATS1/2, TAZ were much lower than the control subjects...
  68. Dang T, Willet J, Griffin H, Morgan N, O Boyle G, Arkwright P, et al. Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency. J Clin Immunol. 2016;36:117-22 pubmed publisher
    To investigate the clinical and functional aspects of MST1 (STK4) deficiency in a profoundly CD4-lymphopenic kindred with a novel homozygous nonsense mutation in STK4...
  69. Xu L, Liang W, Wen Y, Wang L, Yang X, Ren S, et al. An ultrasensitive electrochemical biosensor for the detection of mecA gene in methicillin-resistant Staphylococcus aureus. Biosens Bioelectron. 2018;99:424-430 pubmed publisher
    ..analysis of mecA DNA on methicillin-resistant Staphylococcus aureus (MRSA) genome, using a multi-signal probes (MSP) system...
  70. Faas R, Pohle A, Moß K, Henkel M, Hausmann R. Self-assembly of nanoscale particles with biosurfactants and membrane scaffold proteins. Biotechnol Rep (Amst). 2017;16:1-4 pubmed publisher
    ..structures are composed of a phospholipid bilayer held together by an amphipathic membrane scaffold protein (MSP)...
  71. Brent M, Anand R, Marmorstein R. Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification. Structure. 2008;16:1407-16 pubmed publisher
    ..We also show that MST1 phosphorylation of FoxO1 prevents high-affinity DNA binding...
  72. Lin Z, Pu W. Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation. Stem Cell Res. 2014;13:571-81 pubmed publisher
    ..Here we provide a brief overview of the Hippo/Yap pathway and its known roles in the developing and adult heart. We discuss the implications of Hippo/Yap signaling for regulation of cardiomyocyte death and regeneration. ..
  73. Julia A, Domenech E, Chaparro M, Garcia Sanchez V, Gomollon F, Panes J, et al. A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis. Hum Mol Genet. 2014;23:6927-34 pubmed publisher
    ..Our results provide new insight into the genetic risk background of UC, confirming that there is a genetic risk component that differentiates from Crohn's Disease, the other major form of inflammatory bowel disease. ..
  74. Zuo Q, Zheng W, Zhang J, Pan Z, Liu Y, Long H, et al. Methylation in the promoters of HS3ST2 and CCNA1 genes is associated with cervical cancer in Uygur women in Xinjiang. Int J Biol Markers. 2014;29:e354-62 pubmed publisher
    ..Methylation-specific PCR (MSP) and HPV (HPV16 and HPV18)-specific PCR were performed on 110 cervical samples: 40 normal cervices, 10 cervical ..
  75. Natividad L, Buczynski M, Herman M, Kirson D, Oleata C, Irimia C, et al. Constitutive Increases in Amygdalar Corticotropin-Releasing Factor and Fatty Acid Amide Hydrolase Drive an Anxious Phenotype. Biol Psychiatry. 2017;82:500-510 pubmed publisher
    ..Here, we used genetically selected Marchigian Sardinian P (msP) rats carrying an innate overexpression of CRF1 receptors to study the role of constitutive upregulation ..
  76. Deng C, Chen S, Jiang M, Nilupar T, Wang H, Hao J. [Prognostic Value of Multigene Methylation in Patients with Myelodysplastic Syndrome]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1118-1122 pubmed publisher
    ..Methylation-specific PCR (MSP) was used to detect the methylation of the above-mentioned 4 genes in 67 patients with MDS and 18 patients with ..
  77. Shi L, Lei J, Xu H, Zheng J, Wang Y, Peng Y, et al. Hydrogen sulfide ameliorates subarachnoid hemorrhage-induced neuronal apoptosis via the ROS-MST1 pathway. Oncotarget. 2017;8:73547-73558 pubmed publisher
    ..Hydrogen sulfide (H2S) has shown a neuroprotective role in several cerebrovascular diseases. This study aimed to explore the underlying mechanisms of H2S in early brain injury after subarachnoid hemorrhage (SAH)...
  78. Mao T, Li J, Liu L, Zhao W, Liu Y, Gao K, et al. Qingchang Wenzhong Decoction Attenuates DSS-Induced Colitis in Rats by Reducing Inflammation and Improving Intestinal Barrier Function via Upregulating the MSP/RON Signalling Pathway. Evid Based Complement Alternat Med. 2017;2017:4846876 pubmed publisher
    ..QCWZD was administered daily for 7 days; then we determined the serum macrophage-stimulating protein concentration (MSP) and recepteur d'origine nantais (RON) expression and its downstream proteins (protein kinase B [Akt], ..
  79. Skeel A, Leonard E. alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro-macrophage stimulating protein. J Biol Chem. 2001;276:21932-7 pubmed
    b>Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484)...
  80. Qiu Q, Yang L, Mai J, Yang Y, Xie Y, Chen Y, et al. Acute Effects of Multisite Biventricular Pacing on Dyssynchrony and Hemodynamics in Canines With Heart Failure. J Card Fail. 2017;23:304-311 pubmed publisher
    Multisite biventricular pacing (MSP) has been proposed as an alternative strategy to improve the efficiency of conventional biventricular pacing (BVP), but its utility remains unclear...
  81. He J, Huang Y, Liu Z, Zhao R, Liu Q, Wei L, et al. Hypomethylation of BORIS is a promising prognostic biomarker in hepatocellular carcinoma. Gene. 2017;629:29-34 pubmed publisher
    ..In this study, the methylation status of BORIS was tested by methylation specific polymerase chain reaction (MSP) in human HCC cell lines and 43 pairs of tissue specimens...
  82. Green M, Bloom J, Kulbersh R. A simple and accurate craniofacial midsagittal plane definition. Am J Orthod Dentofacial Orthop. 2017;152:355-363 pubmed publisher
    In this article, we aimed to establish an ideal definition for the craniofacial midsagittal plane (MSP) by first finding an optimal "plane of best fit" and then deriving a simple approximation for clinical use that is highly accurate...
  83. Ishihara S, Labuta J, Nakanishi T, Tanaka T, Kataura H. Amperometric Detection of Sub-ppm Formaldehyde Using Single-Walled Carbon Nanotubes and Hydroxylamines: A Referenced Chemiresistive System. ACS Sens. 2017;2:1405-1409 pubmed publisher
    ..The debundling of SWCNTs with a metallo-supramolecular polymer (MSP) increased the active surface area in the SWCNTs network, leading to excellent sensitivity to HCHO with a limit of ..
  84. Li Y, Shao L, Jiang T, Liu Y, Chang Q. [miR-449a is a potential epigenetic biomarker for WNT subtype of medulloblastoma]. Zhonghua Bing Li Xue Za Zhi. 2017;46:684-689 pubmed publisher
    ..Methylation specific PCR (MSP) assay confirmed miR-449a was silenced due to aberrant DNA methylation in MB cell lines...
  85. Zhao Q, Ye M, Yang W, Wang M, Li M, Gu C, et al. Effect of Mst1 on Endometriosis Apoptosis and Migration: Role of Drp1-Related Mitochondrial Fission and Parkin-Required Mitophagy. Cell Physiol Biochem. 2018;45:1172-1190 pubmed publisher
    ..b>Mst1 is the major growth suppressor related to cancer migration, apoptosis and proliferation...
  86. Gerber M, Drabkin H, Firnhaber C, Miller Y, Scoggin C, Smith D. Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel. Am J Hum Genet. 1988;43:442-51 pubmed
    ..2. In addition, three fragments previously assigned to chromosome 3 were confirmed. Polymorphic DNA probes DNF15S2 (formerly D1S1) and D3S2 were mapped to 3p14.2----pter...
  87. Wen W, Zhu F, Zhang J, Keum Y, Zykova T, Yao K, et al. MST1 promotes apoptosis through phosphorylation of histone H2AX. J Biol Chem. 2010;285:39108-16 pubmed publisher
    b>MST1 (mammalian STE20-like kinase 1) is a serine/threonine kinase that is cleaved and activated by caspases during apoptosis...
  88. You B, Huang S, Qin Q, Yi B, Yuan Y, Xu Z, et al. Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis. PLoS ONE. 2013;8:e58697 pubmed publisher
    Mammalian sterile 20-like kinase 1 (Mst1) is a critical component of the Hippo signaling pathway, which regulates a variety of biological processes ranging from cell contact inhibition, organ size control, apoptosis and tumor suppression ..
  89. Van de Laar E, Clifford M, Hasenoeder S, Kim B, Wang D, Lee S, et al. Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas. Respir Res. 2014;15:160 pubmed publisher
    ..We also identified 33 signaling receptors, including the MST1R/RON growth factor receptor, whose ligand MST1/MSP was mitogenic for basal cells...
  90. Rocha M, Françoso K, Lima L, Camargo T, Machado R, Costa F, et al. Generation, characterization and immunogenicity of a novel chimeric recombinant protein based on Plasmodium vivax AMA-1 and MSP119. Vaccine. 2017;35:2463-2472 pubmed publisher
    ..Apical Membrane Antigen 1 (AMA-1) ectodomain and the C-terminal region (19kDa) of the Merozoite Surface Protein 1 (MSP-1) of P. vivax as immunodominant antigens...
  91. Wang S, Ding M, Duan X, Wang T, Feng X, Wang P, et al. Detection of the Single Nucleotide Polymorphism at Position rs2735940 in the Human Telomerase Reverse Transcriptase Gene by the Introduction of a New Restriction Enzyme Site for the PCR-RFLP Assay. Ann Clin Lab Sci. 2017;47:546-550 pubmed
    ..cutting site was created by created restriction site PCR (CRS-PCR), and in addition, the restriction enzyme MspI for CRS-PCR was cheaper than other enzymes...
  92. Stopponi S, Fotio Y, Domi A, Borruto A, NATIVIDAD L, Roberto M, et al. Inhibition of fatty acid amide hydrolase in the central amygdala alleviates co-morbid expression of innate anxiety and excessive alcohol intake. Addict Biol. 2017;: pubmed publisher
    ..Recently, we found that genetically selected Marchigian Sardinian alcohol-preferring (msP) rats display hyperactive FAAH in amygdalar regions that was associated with increased stress sensitivity and a ..