Gene Symbol: MS4A8
Description: membrane spanning 4-domains A8
Alias: 4SPAN4, CD20L5, MS4A4, MS4A8B, membrane-spanning 4-domains subfamily A member 8, four-span transmembrane protein 4, membrane-spanning 4-domains, subfamily A, member 8B
Liang Y, Tedder T. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics. 2001;72:119-27 pubmed
..1 along with CD20, FcepsilonRIbeta, and HTm4. Thus, like CD20 and FcepsilonRIbeta, the other MS4A family members are likely to be components of oligomeric cell surface complexes that serve diverse signal transduction functions. ..
Ishibashi K, Suzuki M, Sasaki S, Imai M. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. Gene. 2001;264:87-93 pubmed
..The identification of this relatively large gene family in various tissues will allow the further elucidation of physiological significance of this gene family, that is currently unclear. ..
Naj A, Jun G, Beecham G, Wang L, Vardarajan B, Buros J, et al
. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011;43:436-41 pubmed publisher
..9 Ã— 10(-8)), BIN1 (rs7561528; P(M) = 4.0 Ã— 10(-14), P(J) = 5.2 Ã— 10(-14)) and PICALM (rs561655; P(M) = 7.0 Ã— 10(-11), P(J) = 1.0 Ã— 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility. ..
Cruse G, Beaven M, Music S, Bradding P, Gilfillan A, Metcalfe D. The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling. Mol Biol Cell. 2015;26:1711-27 pubmed publisher
..Here we report that MS4A4 facilitates trafficking of the receptor tyrosine kinase KIT through endocytic recycling rather than degradation ..
Leyten G, Hessels D, Smit F, Jannink S, de Jong H, Melchers W, et al
. Identification of a Candidate Gene Panel for the Early Diagnosis of Prostate Cancer. Clin Cancer Res. 2015;21:3061-70 pubmed publisher
..biomarkers for the urinary detection of prostate cancer were selected (ONECUT2, HOXC4, HOXC6, DLX1, TDRD1, NKAIN1, MS4A8B, PPFIA2)...
Michel J, Schönhaar K, Schledzewski K, Gkaniatsou C, Sticht C, Kellert B, et al
. Identification of the novel differentiation marker MS4A8B and its murine homolog MS4A8A in colonic epithelial cells lost during neoplastic transformation in human colon. Cell Death Dis. 2013;4:e469 pubmed publisher
..Here, MS4A8A/MS4A8B expression was detected in differentiated intestinal epithelium in mouse and human, respectively...
Liang Y, Buckley T, Tu L, Langdon S, Tedder T. Structural organization of the human MS4A gene cluster on Chromosome 11q12. Immunogenetics. 2001;53:357-68 pubmed
..Like CD20 and FcepsilonRIbeta, the 10 other human MS4A family members are likely to be components of oligomeric cell surface complexes involved in signal transduction in diverse cell lineages. ..