Genomes and Genes
Gene Symbol: MS4A4E
Description: membrane spanning 4-domains A4E
Alias: membrane-spanning 4-domains, subfamily A, member 4E
- Hollingworth P, Harold D, Sims R, Gerrish A, Lambert J, Carrasquillo M, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet. 2011;43:429-35 pubmed publisher..6 Ã— 10(-9)), CD33 (GERAD+, P = 2.2 Ã— 10(-4); including ADGC data, meta P = 1.6 Ã— 10(-9)) and EPHA1 (GERAD+, P = 3.4 Ã— 10(-4); including ADGC data, meta P = 6.0 Ã— 10(-10)). ..
- Chu A, Guilianini F, Grallert H, Dupuis J, Ballantyne C, Barratt B, et al. Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy. Circ Cardiovasc Genet. 2012;5:676-85 pubmed publisher..Novel associations were identified and replicated at MS4A4E and TMEM49 for baseline Lp-PLA(2) activity with genome-wide significant joint P values (P=2.0 × 10(-11) and P=2...
- Ebbert M, Boehme K, Wadsworth M, Staley L, Mukherjee S, Crane P, et al. Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement. 2016;12:121-129 pubmed publisherEbbert etÂ al. reported gene-gene interactions between rs11136000-rs670139 (CLU-MS4A4E) and rs3865444-rs670139 (CD33-MS4A4E). We evaluate these interactions in the largest data set for an epistasis study...
- Bressler J, Mosley T, Penman A, Gottesman R, Windham B, Knopman D, et al. Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study. Am J Med Genet B Neuropsychiatr Genet. 2017;174:269-282 pubmed publisher..Addition of the minor allele for rs670139 (MS4A4E), rs9331896 (CLU), and rs12155159 (NME8) was nominally associated with change on the DWRT, DSST, and WFT, ..