Gene Symbol: MS4A4A
Description: membrane spanning 4-domains A4A
Alias: 4SPAN1, CD20-L1, CD20L1, HDCME31P, MS4A4, MS4A7, membrane-spanning 4-domains subfamily A member 4A, CD20 antigen-like 1, Fc epsilon receptor beta subunit homolog, four-span transmembrane protein 1, membrane-spanning 4-domains, subfamily A, member 4
Species: human
Products:     MS4A4A

Top Publications

  1. Naj A, Jun G, Beecham G, Wang L, Vardarajan B, Buros J, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011;43:436-41 pubmed publisher
    ..Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P(M)) = 1.7 × 10(-9), joint analysis P (P(J)) = 1...
  2. Lin E, Tsai S, Kuo P, Liu Y, Yang A, Kao C. Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. Oncotarget. 2017;8:24077-24087 pubmed publisher
  3. Yang T, Ahmari N, Schmidt J, Redler T, Arocha R, Pacholec K, et al. Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon. Front Physiol. 2017;8:220 pubmed publisher
  4. Ishizu A, Tomaru U, Masuda S, Sada K, Amano K, Harigai M, et al. Prediction of response to remission induction therapy by gene expression profiling of peripheral blood in Japanese patients with microscopic polyangiitis. Arthritis Res Ther. 2017;19:117 pubmed publisher
    ..We earlier nominated 16 genes (IRF7, IFIT1, IFIT5, OASL, CLC, GBP-1, PSMB9, HERC5, CCR1, CD36, MS4A4A, BIRC4BP, PLSCR1, DEFA1/DEFA3, DEFA4, and COL9A2) as predictors of response to remission induction therapy against ..
  5. Chen H, Zhao J, Li Y, He L, Huang Y, Shu W, et al. Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. Toxicol Lett. 2018;289:42-53 pubmed publisher
    ..domain containing 180 (CCDC180), melanoma antigen gene family member D1 (MAGED1), membrane spanning 4-domains A7 (MS4A7), hephaestin like 1 (HEPHL1), BH3 (Bcl-2 homology 3)-like motif containing, cell death inducer (BLID), matrix ..
  6. Houlahan K, Prokopec S, Sun R, Moffat I, Lindén J, Lensu S, et al. Transcriptional profiling of rat white adipose tissue response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin. Toxicol Appl Pharmacol. 2015;288:223-31 pubmed publisher
    ..were significantly induced by TCDD in both strains, while several genes involved in the immune response, including Ms4a7 and F13a1 were altered in L-E rats alone...
  7. Rice L, Ziemek J, Stratton E, McLaughlin S, Padilla C, Mathes A, et al. A longitudinal biomarker for the extent of skin disease in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheumatol. 2015;67:3004-15 pubmed publisher
    ..This modeling method selected cross-sectional THBS1 and longitudinal THBS1 and MS4A4A. The second model was based on a weighted selection of genes, including additional genes that changed ..
  8. Ishibashi K, Suzuki M, Sasaki S, Imai M. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. Gene. 2001;264:87-93 pubmed
    ..The identification of this relatively large gene family in various tissues will allow the further elucidation of physiological significance of this gene family, that is currently unclear. ..
  9. Liang Y, Tedder T. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics. 2001;72:119-27 pubmed
    ..1 along with CD20, FcepsilonRIbeta, and HTm4. Thus, like CD20 and FcepsilonRIbeta, the other MS4A family members are likely to be components of oligomeric cell surface complexes that serve diverse signal transduction functions. ..

More Information


  1. Sanyal R, Polyak M, Zuccolo J, Puri M, Deng L, Roberts L, et al. MS4A4A: a novel cell surface marker for M2 macrophages and plasma cells. Immunol Cell Biol. 2017;95:611-619 pubmed publisher
    b>MS4A4A is a member of the membrane-spanning, four domain family, subfamily A (MS4A) that includes CD20 (MS4A1), FcR? (MS4A2) and Htm4 (MS4A3)...
  2. Lefaucheur C, Viglietti D, Hidalgo L, Ratner L, Bagnasco S, Batal I, et al. Complement-Activating Anti-HLA Antibodies in Kidney Transplantation: Allograft Gene Expression Profiling and Response to Treatment. J Am Soc Nephrol. 2018;29:620-635 pubmed publisher capillaries and increased expression of five biologically relevant genes (CXCL11, CCL4, MS4A7, MS4A6A, and FCGR3A) indicative of endothelial activation, IFN? response, CD16-mediated ..
  3. Liang Y, Buckley T, Tu L, Langdon S, Tedder T. Structural organization of the human MS4A gene cluster on Chromosome 11q12. Immunogenetics. 2001;53:357-68 pubmed
    ..Sequence polymorphisms were identified in the MS4A6E gene and common splice variants were observed for the MS4A4A, MS4A5, MS4A6A, and MS4A7 genes. Thus, the MS4A family currently includes 24 distinct human and mouse genes...
  4. Elias Sonnenschein L, Helisalmi S, Natunen T, Hall A, Paajanen T, Herukka S, et al. Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort. PLoS ONE. 2013;8:e59676 pubmed publisher
    ..All participants were from academic hospital and research institutions in Finland. APOE-?4, CLU rs11136000, and MS4A4A rs2304933 correlated with significantly decreased A?(1-42) (corrected p<0.05). At an uncorrected p<0...
  5. Cruse G, Beaven M, Music S, Bradding P, Gilfillan A, Metcalfe D. The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling. Mol Biol Cell. 2015;26:1711-27 pubmed publisher
    ..Here we report that MS4A4 facilitates trafficking of the receptor tyrosine kinase KIT through endocytic recycling rather than degradation ..
  6. Kajiwara Y, McKenzie A, Dorr N, Gama Sosa M, Elder G, Schmeidler J, et al. The human-specific CASP4 gene product contributes to Alzheimer-related synaptic and behavioural deficits. Hum Mol Genet. 2016;25:4315-4327 pubmed publisher
    ..that the expression of caspase-4 was strongly correlated with AD risk genes including TYROBP, TREM2, CR1, PSEN1, MS4A4A and MS4A6A in LOAD brains...