Gene Symbol: MS4A3
Description: membrane spanning 4-domains A3
Alias: CD20L, HTM4, membrane-spanning 4-domains subfamily A member 3, CD20 antigen homolog, CD20 antigen-like protein, IgE receptor beta chain, IgE receptor beta subunit, hematopoietic cell 4 transmembrane protein, hematopoietic-specific transmembrane protein 4, membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
Species: human
Products:     MS4A3

Top Publications

  1. Bruchova Votavova H, Yoon D, Prchal J. miR-451 enhances erythroid differentiation in K562 cells. Leuk Lymphoma. 2010;51:686-93 pubmed publisher
    ..Microarray data suggested potential targets regulated by miR-451: UBE2H, ARPP-19; and by miR-150: MS4A3, AGA, PTPRR...
  2. Mirza Z, Sastri B, Lin J, Amenta P, Das K. Autoimmunity against human tropomyosin isoforms in ulcerative colitis: localization of specific human tropomyosin isoforms in the intestine and extraintestinal organs. Inflamm Bowel Dis. 2006;12:1036-43 pubmed
    ..b>HTM4 is localized in the endothelial cells and basement membrane of the colonic epithelium...
  3. Nettiksimmons J, TRANAH G, Evans D, Yokoyama J, Yaffe K. Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. Age (Dordr). 2016;38:41 pubmed publisher
    ..CLU, complement receptor 1 (CR1), EPHA1, EXOC3L2, FERMT2, HLA cluster (DRB5-DQA), INPP5D, MEF2C, MS4A cluster (MS4A3-MS4A6E), NME8, PICALM, PTK2B, SLC24A4, SORL1, and ZCWPW1 have been associated with Alzheimer's disease (AD) in ..
  4. Sanyal R, Polyak M, Zuccolo J, Puri M, Deng L, Roberts L, et al. MS4A4A: a novel cell surface marker for M2 macrophages and plasma cells. Immunol Cell Biol. 2017;95:611-619 pubmed publisher
    ..the membrane-spanning, four domain family, subfamily A (MS4A) that includes CD20 (MS4A1), FcR? (MS4A2) and Htm4 (MS4A3)...
  5. Gagez A, Duroux Richard I, Lepretre S, Orsini Piocelle F, Letestu R, de Guibert S, et al. miR-125b and miR-532-3p predict the efficiency of rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients. A French Innovative Leukemia Organization study. Haematologica. 2017;102:746-754 pubmed publisher
    ..acids were negatively correlated with MS4A1 expression, while they were positively correlated with MS4A3 and MSA47 Our results identify novel circulating predictive biomarkers for rituximab-mediated ..
  6. Ishibashi T, Yokota T, Satoh Y, Ichii M, Sudo T, Doi Y, et al. Identification of MS4A3 as a reliable marker for early myeloid differentiation in human hematopoiesis. Biochem Biophys Res Commun. 2018;495:2338-2343 pubmed publisher
    ..The results drew our attention to membrane-spanning 4-domains, subfamily A, member 3 (Ms4a3) as the most downregulated molecule in HSPCs with forced overexpression of SATB1...
  7. Adra C, Lelias J, Kobayashi H, Kaghad M, Morrison P, Rowley J, et al. Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions. Proc Natl Acad Sci U S A. 1994;91:10178-82 pubmed
    ..and expression of this gene in diverse hematopoietic lineages of lymphoid and myeloid origin, we named the gene HTm4. The protein is about 20% homologous to two other "four-transmembrane" proteins; the B-cell-specific ..
  8. Skov V, Burton M, Thomassen M, Stauffer Larsen T, Riley C, Brinch Madelung A, et al. A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis. PLoS ONE. 2016;11:e0161570 pubmed publisher
    ..The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8, which are genes known to be involved in inflammation, cell adhesion, differentiation ..
  9. Heller G, Rommer A, Steinleitner K, Etzler J, Hackl H, Heffeter P, et al. EVI1 promotes tumor growth via transcriptional repression of MS4A3. J Hematol Oncol. 2015;8:28 pubmed publisher
    ..qRT-PCR was used to confirm the regulation of membrane-spanning-4-domains subfamily-A member-3 (MS4A3) by EVI1...

More Information


  1. Kutok J, Yang X, Folkerth R, Adra C. Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues. J Cell Mol Med. 2011;15:86-93 pubmed publisher
    HTm4 (MS4A3) is a member of a family of four-transmembrane proteins designated MS4A. MS4A proteins fulfil diverse functions, acting as cell surface signalling molecules and intracellular adapter proteins...
  2. Li J, Xie C, Xie X, Wang D, Pei X. [Regulatory role of HTm4 gene in hematopoietic cell cycle]. Sheng Li Xue Bao. 2005;57:188-92 pubmed
    ..Proper cell cycle regulation is a pivotal element for the maintenance of hematopoiesis homeostasis. HTm4 is a newly identified specific cell cycle regulator of the hematopoietic cell...
  3. Chinami M, Yano Y, Yang X, Salahuddin S, Moriyama K, Shiroishi M, et al. Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. J Biol Chem. 2005;280:17235-42 pubmed
    ..We have reported that KAP is bound and activated by a nuclear membrane protein, HTm4. Here, we present in vitro data showing the direct interaction between the HTm4 C terminus and KAP Tyr141...
  4. Donato J, Ko J, Kutok J, Cheng T, Shirakawa T, Mao X, et al. Human HTm4 is a hematopoietic cell cycle regulator. J Clin Invest. 2002;109:51-8 pubmed
    ..Here we describe a novel protein, HTm4, which serves as a hematopoietic cell cycle regulator...
  5. Liang Y, Buckley T, Tu L, Langdon S, Tedder T. Structural organization of the human MS4A gene cluster on Chromosome 11q12. Immunogenetics. 2001;53:357-68 pubmed
    CD20, the high-affinity IgE receptor beta chain (FcepsilonRIbeta), and HTm4 are structurally related cell surface proteins expressed by hematopoietic cells...
  6. Liang Y, Tedder T. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics. 2001;72:119-27 pubmed
    CD20, high-affinity IgE receptor beta chain (FcepsilonRIbeta), and HTm4 are structurally related cell-surface proteins expressed by hematopoietic cells...
  7. Lin X, Lu D, Gao Y, Tao S, Yang X, Feng J, et al. Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. Hum Mol Genet. 2012;21:2610-7 pubmed publisher
    ..00 × 10(-8). These four loci were MS4A3 (11q12.1; rs2298585; P= 2.64 × 10(-15)), CLYBL (13q32; rs41281112; P= 9.23 × 10(-10)), FUT6 (19p13...
  8. Pérez Palma E, Bustos B, Villamán C, Alarcón M, Avila M, Ugarte G, et al. Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies. PLoS ONE. 2014;9:e95413 pubmed publisher