Gene Symbol: MS4A2
Description: membrane spanning 4-domains A2
Alias: APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1, high affinity immunoglobulin epsilon receptor subunit beta, Fc fragment of IgE, high affinity I, receptor for; beta polypeptide, High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain), high affinity IgE receptor beta subunit, igE Fc receptor subunit beta, immunoglobulin E receptor, high affinity, beta polypeptide, membrane-spanning 4-domains subfamily A member 2
Species: human
Products:     MS4A2

Top Publications

  1. Shirakawa T, Li A, Dubowitz M, Dekker J, Shaw A, Faux J, et al. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. Nat Genet. 1994;7:125-9 pubmed
    The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis...
  2. Sandford A, Shirakawa T, Moffatt M, Daniels S, Ra C, Faux J, et al. Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet. 1993;341:332-4 pubmed
    b>Atopy, a common familial syndrome underlying allergic asthma and rhinitis, is characterised by sustained immunoglobulin E (IgE) responses to common allergens...
  3. Hill M, Cookson W. A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness. Hum Mol Genet. 1996;5:959-62 pubmed
    ..04), RAST to grass (p = 0.002) and bronchial reactivity to methacholine (p = 0.0009). The relative risk of individuals with E237G having asthma compared to subjects without the variant was 2.3 (95% CI 1.26-4.19; p = 0.005). ..
  4. Hizawa N, Yamaguchi E, Jinushi E, Konno S, Kawakami Y, Nishimura M. Increased total serum IgE levels in patients with asthma and promoter polymorphisms at CTLA4 and FCER1B. J Allergy Clin Immunol. 2001;108:74-9 pubmed
    ..are largely determined by genetic factors, and we recently established that the -109C/T promoter polymorphism at FCER1B is a genetic factor that affects total serum IgE levels...
  5. Hizawa N, Maeda Y, Konno S, Fukui Y, Takahashi D, Nishimura M. Genetic polymorphisms at FCER1B and PAI-1 and asthma susceptibility. Clin Exp Allergy. 2006;36:872-6 pubmed
    ..detected a promoter polymorphism (- 109C/T) in the gene for the beta-chain of the high-affinity receptor for IgE (FCER1B), which was associated with total serum IgE levels but not with asthma in a Japanese population...
  6. Ljubojević Hadžavdić S, Marinovic Kulisic S, Ljubojević Grgec D, Poljanac A, Ilić B. Autoimmune Progesterone Dermatitis Diagnosed by Lymphocyte Transformation Test and Progesterone Provocation Test. Acta Dermatovenerol Croat. 2018;26:276-277 pubmed
    ..We had performed control LTT in 10 healthy controls and 10 patients with atopy, and such hyperactivity was not observed in any of them...
  7. Chua H, Chou H, Tung Y, Chiang B, Liao C, Liu H, et al. Intestinal Dysbiosis Featuring Abundance of Ruminococcus gnavus Associates With Allergic Diseases in Infants. Gastroenterology. 2018;154:154-167 pubmed publisher
    ..A skin prick test was used to ascertain atopy. Bacterial communities in fecal samples were profiled by 16S ribosomal RNA-based polymerase chain reaction-..
  8. Hay J, Danel C, Chu C, Crystal R. Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease. Am J Physiol. 1995;268:L565-75 pubmed
    ..loci localized the CC10 gene to 11 p12-q13 between markers D11S16 and D11S97, a region recently linked to atopy and to the beta-subunit of the high-affinity immunoglobulin E receptor...
  9. Sezer E, Oztürk Durmaz E, Cetin E, Sahin S. Meyerson Phenomenon as a Component of Melanoma in situ. Acta Dermatovenerol Croat. 2016;24:81-2 pubmed
    ..History of atopy and atopic dermatitis is observed in a subset of patients, which was absent in our case...

More Information

Publications146 found, 100 shown here

  1. Zemba M, Burcea M, Camburu G. Atopic keratoconjunctivitis with corneal ulcer. Case report. Rom J Ophthalmol. 2016;60:200-206 pubmed
    ..The patient's past medical history was significant for atopic dermatitis (AD) and he had a family history for atopy. At the eye exam: his best-corrected visual acuity at the initial presentation was 0.2 in the right eye and 1...
  2. Ombrello M, Remmers E, Sun G, Freeman A, Datta S, Torabi Parizi P, et al. Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med. 2012;366:330-8 pubmed publisher
    ..Cold urticaria occurred in all affected subjects. Other, variable manifestations included atopy, granulomatous rash, autoimmune thyroiditis, the presence of antinuclear antibodies, sinopulmonary infections, and ..
  3. Hüls A, Abramson M, Sugiri D, Fuks K, Kramer U, Krutmann J, et al. Nonatopic eczema in elderly women: Effect of air pollution and genes. J Allergy Clin Immunol. 2019;143:378-385.e9 pubmed publisher
    ..We sought to examine the association between air pollution, atopy, and eczema in adulthood...
  4. Theoharides T, Athanassiou M, Panagiotidou S, Doyle R. Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders. J Neuroimmunol. 2015;279:33-8 pubmed publisher
    ..PubMed was searched (2005-2014) using the terms: allergy, atopy, brain, brain-derived neurotrophic factor (BDNF), corticotropin-releasing hormone (CRH), cytokines, gene mutations,..
  5. Goronfolah L. Aeroallergens, atopy and allergic rhinitis in the Middle East. Eur Ann Allergy Clin Immunol. 2016;48:5-21 pubmed
    The literature on the nature and prevalence of indoor and/or outdoor aeroallergens, atopy and symptoms of rhinitis and asthma in the Middle East region (defined here as Bahrain, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Oman, ..
  6. Yamasaki R, Fujii T, Wang B, Masaki K, Kido M, Yoshida M, et al. Allergic Inflammation Leads to Neuropathic Pain via Glial Cell Activation. J Neurosci. 2016;36:11929-11945 pubmed
    ..had widespread and significantly more activated microglia and astroglia in the spinal cord than those without atopy, and displayed tactile allodynia...
  7. Srikakulapu P, Hu D, Yin C, Mohanta S, Bontha S, Peng L, et al. Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice. Arterioscler Thromb Vasc Biol. 2016;36:1174-85 pubmed publisher ATLOs versus atherosclerotic lesions: ATLOs showed upregulation of bona fide B-cell genes, including Cd19, Ms4a1 (Cd20), Cd79a/b, and Ighm although intima plaques preferentially expressed molecules involved in non-B effector ..
  8. Lindsley K, Matsumura S, Hatef E, Akpek E. Interventions for chronic blepharitis. Cochrane Database Syst Rev. 2012;:CD005556 pubmed publisher
    ..with bacteria, infestations with certain parasites such as demodex, and inflammatory skin conditions such as atopy and seborrhea. Blepharitis can be categorized in several different ways...
  9. Lu C, Deng Q, Li Y, Sundell J, Norback D. Outdoor air pollution, meteorological conditions and indoor factors in dwellings in relation to sick building syndrome (SBS) among adults in China. Sci Total Environ. 2016;560-561:186-96 pubmed publisher
    ..Asthma or allergic rhinitis (atopy) was associated with all types of SBS symptoms except fatigue. Indoor factors played a major role in SBS symptoms...
  10. Miller J. The Role of Dust Mites in Allergy. Clin Rev Allergy Immunol. 2018;: pubmed publisher
    ..Beyond their direct importance as a major allergen source, an understanding of dust mites leads to insights into the nature of atopy and of allergic sensitization in general.
  11. Spiewak R, Góra Florek A, Horoch A, Jarosz M, Dorynska A, Golec M, et al. Risk factors for work-related eczema and urticaria among vocational students of agriculture. Ann Agric Environ Med. 2017;24:716-721 pubmed publisher
    ..61; p=0.013). Work-related skin diseases are common among vocational students of agriculture. Atopy, past history of asthma, allergic rhinitis, and eczema (either atopic, allergic or irritant) are relevant risk ..
  12. Evcimik M, Dogru M, Cirik A, Nepesov M. Adenoid hypertrophy in children with allergic disease and influential factors. Int J Pediatr Otorhinolaryngol. 2015;79:694-7 pubmed publisher
    ..effect of variables on AH presence (according to age, gender, cigarette smoke exposure, asthma, AR, AD presence, atopy presence, sensitivity to house dust, pollen, epithelium, Alternaria alternata and cockroach), AR presence and ..
  13. Munblit D, Treneva M, Peroni D, Colicino S, Chow L, Dissanayeke S, et al. Immune Components in Human Milk Are Associated with Early Infant Immunological Health Outcomes: A Prospective Three-Country Analysis. Nutrients. 2017;9: pubmed publisher
    ..immune mediators in human milk (HM) play a critical role in infant immune maturation as well as protection against atopy/allergy development...
  14. Queiroz G, Costa R, Alcantara Neves N, Nunes de Oliveira Costa G, Barreto M, Carneiro V, et al. IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population. Int J Immunogenet. 2017;44:51-61 pubmed publisher
    ..tropicalis, the greater the number of risk alleles for both SNPs. Our findings demonstrate a robust association of genetic variants in IL1RL1 and IL33 SNPs with allergy markers and asthma. ..
  15. Sanyal R, Polyak M, Zuccolo J, Puri M, Deng L, Roberts L, et al. MS4A4A: a novel cell surface marker for M2 macrophages and plasma cells. Immunol Cell Biol. 2017;95:611-619 pubmed publisher
    MS4A4A is a member of the membrane-spanning, four domain family, subfamily A (MS4A) that includes CD20 (MS4A1), FcR? (MS4A2) and Htm4 (MS4A3)...
  16. Zhang Q, Davis J, Lamborn I, Freeman A, Jing H, Favreau A, et al. Combined immunodeficiency associated with DOCK8 mutations. N Engl J Med. 2009;361:2046-55 pubmed publisher
    ..Most patients had severe atopy with anaphylaxis; several had squamous-cell carcinomas, and one had T-cell lymphoma-leukemia...
  17. Barnes S, Stuart R, Redley B. Health care worker sensitivity to chlorhexidine-based hand hygiene solutions: A cross-sectional survey. Am J Infect Control. 2019;: pubmed publisher
    ..9%). There was a correlation between both the presence of atopy, eczema, or dermatitis and the self-reporting of dry skin, eczema, or dermatitis attributed to chlorhexidine use...
  18. Uysal P, Avcil S, Abas B, Yenisey C. Evaluation of Oxidant-Antioxidant Balance in Children with Atopic Dermatitis: A Case-Control Study. Am J Clin Dermatol. 2016;17:527-537 pubmed
    ..The severity of AD was evaluated by the scoring AD (SCORAD) index, and atopy was determined by skin prick tests (SPTs) with commercial extracts...
  19. Rojano E, Ranea J, Perkins J. Characterisation of non-coding genetic variation in histamine receptors using AnNCR-SNP. Amino Acids. 2016;48:2433-42 pubmed publisher
    ..A number of allergy and atopy related diseases such as asthma and atopic dermatitis are related to histamine receptors; however, these diseases ..
  20. Alhmoud T, Hanson J, Parasher G. Eosinophilic Gastroenteritis: An Underdiagnosed Condition. Dig Dis Sci. 2016;61:2585-92 pubmed publisher
    ..b>Atopy and food allergies were present in 54 and 38 % of patients, respectively...
  21. Alcântara Neves N, de S G Britto G, Veiga R, Figueiredo C, Fiaccone R, da Conceição J, et al. Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America. BMC Res Notes. 2014;7:817 pubmed publisher
  22. Makamure M, Reddy P, Chuturgoon A, Naidoo R, Mentz G, Batterman S, et al. Tumour necrosis factor ? polymorphism (TNF-308? G/A) in association with asthma related phenotypes and air pollutants among children in KwaZulu-Natal. Asian Pac J Allergy Immunol. 2016;34:217-222 pubmed
    ..b>Atopy was evaluated by skin prick testing...
  23. Pires A, Queiroz G, de Jesus Silva M, da Silva R, da Silva H, Carneiro N, et al. Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population. Mol Immunol. 2018;101:294-302 pubmed publisher
    ..This study aimed to evaluate how polymorphisms in DAD1 and OXA1L are associated with asthma and markers of atopy in individuals from the Salvador cohort of the SCAALA (Social Change Asthma and Allergy in Latin America) program...
  24. Cerhan J, Kricker A, Paltiel O, Flowers C, Wang S, Monnereau A, et al. Medical history, lifestyle, family history, and occupational risk factors for diffuse large B-cell lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project. J Natl Cancer Inst Monogr. 2014;2014:15-25 pubmed publisher
    ..69, 95% CI = 0.57 to 0.83). Autoimmune disease, atopy, and family history of non-Hodgkin lymphoma showed similar associations across selected anatomical sites, whereas ..
  25. Silverberg J. Association between childhood eczema and headaches: An analysis of 19 US population-based studies. J Allergy Clin Immunol. 2016;137:492-499.e5 pubmed publisher
    ..57]) eczema were associated with significantly higher odds of headaches. In particular, eczema associated with atopy, fatigue, excessive daytime sleepiness, insomnia, and only 0 to 3 nights of sufficient sleep had even higher odds ..
  26. Lee H, Kim B, Im N, Lee D, Kim H, Lee S, et al. Decreased expression of E-cadherin and ZO-1 in the nasal mucosa of patients with allergic rhinitis: Altered regulation of E-cadherin by IL-4, IL-5, and TNF-alpha. Am J Rhinol Allergy. 2016;30:173-8 pubmed publisher
    ..Although atopy is a potent predisposing risk factor for allergic rhinitis, local tissue susceptibilities are inevitable for ..
  27. Zhuge Y, Qian H, Zheng X, Huang C, Zhang Y, Zhang M, et al. Residential risk factors for childhood pneumonia: A cross-sectional study in eight cities of China. Environ Int. 2018;116:83-91 pubmed publisher
    ..model include children's gender, birthweight, breastfeeding duration, parental smoking and family history of atopy. The average lifetime-ever incidence of childhood pneumonia was 32.3%. Urban children (33...
  28. Wang Z, Xue L, Wang T, Wang X, Su Z. Infiltration of invariant natural killer T cells occur and accelerate brain infarction in permanent ischemic stroke in mice. Neurosci Lett. 2016;633:62-68 pubmed publisher
    Invariant natural killer T (iNKT) cells are a unique subset of T cells that have been implicated in inflammation, atopy, autoimmunity, infections, and cancer...
  29. Sanjuan M, Sagar D, Kolbeck R. Role of IgE in autoimmunity. J Allergy Clin Immunol. 2016;137:1651-1661 pubmed publisher
    ..However, studies have shown that the increased IgE concentration is not associated with higher prevalence for atopy and allergy in patients with autoimmune diseases, such as systemic lupus erythematosus...
  30. Wang J, Liou Y, Wu Y, Hsiao Y, Wu L. An association study of 13 SNPs from seven candidate genes with pediatric asthma and a preliminary study for genetic testing by multiple variants in Taiwanese population. J Clin Immunol. 2009;29:205-9 pubmed publisher
    ..CD14-159 C/T and MS4A2 Glu237Gly were identified to have difference in genotype/allele frequencies between the control group and asthma ..
  31. Southern J, Waight P, Andrews N, Miller E. Extensive swelling of the limb and systemic symptoms after a fourth dose of acellular pertussis containing vaccines in England in children aged 3-6years. Vaccine. 2017;35:619-625 pubmed publisher
    ..Pain at the injection site and systemic symptoms did not differ between the four vaccine groups. A history of atopy was not associated with development of local swelling or redness. A total of 13 children (1...
  32. Biggs C, Keles S, Chatila T. DOCK8 deficiency: Insights into pathophysiology, clinical features and management. Clin Immunol. 2017;181:75-82 pubmed publisher
    ..the broad clinical features of primary immunodeficiencies (PIDs), extending beyond recurrent infections to include atopy, autoimmunity and cancer...
  33. Bédard A, Northstone K, Henderson A, Shaheen S. Maternal intake of sugar during pregnancy and childhood respiratory and atopic outcomes. Eur Respir J. 2017;50: pubmed publisher
    ..estimated by a food frequency questionnaire), and current doctor-diagnosed asthma, wheezing, hay fever, eczema, atopy, serum total IgE and lung function in children aged 7-9?years (n=8956 with information on maternal diet in ..
  34. Andoh T, Li S, Uta D. Involvement of thromboxane A2 in interleukin-31-induced itch-associated response in mice. Pharmacol Rep. 2018;70:251-257 pubmed publisher, we have shown that thromboxane (TX) A2 is involved in itch-associated responses in mice with atopy-like skin diseases...
  35. Norbäck D, Hashim J, Markowicz P, Cai G, Hashim Z, Ali F, et al. Endotoxin, ergosterol, muramic acid and fungal DNA in dust from schools in Johor Bahru, Malaysia--Associations with rhinitis and sick building syndrome (SBS) in junior high school students. Sci Total Environ. 2016;545-546:95-103 pubmed publisher
    ..1% dermal symptoms, 20.6% headache and 22.1% tiredness. Totally 21.1% reported pollen or furry pet allergy (atopy) and 22.0% parental asthma or allergy...
  36. Altintoprak N, Kar M, Bayar Muluk N, Oktemer T, Ipci K, Birdane L, et al. Update on local allergic rhinitis. Int J Pediatr Otorhinolaryngol. 2016;87:105-9 pubmed publisher
    ..LAR is a localised nasal allergic response in the absence of systemic atopy characterised by local production of specific IgE (sIgE) antibodies, a TH2 pattern of mucosal cell infiltration ..
  37. Lee E, Lee S, Kwon J, Kim Y, Yoon J, Cho H, et al. Persistent asthma phenotype related with late-onset, high atopy, and low socioeconomic status in school-aged Korean children. BMC Pulm Med. 2017;17:45 pubmed publisher
    ..Four asthma phenotypes were identified. Cluster 1 (22% of children) was characterized by high prevalence of atopy and mild symptoms; subjects in cluster 2 (17%) consisted of less atopy and normal lung function, but intermittent ..
  38. Raulf M, van Kampen V, Neumann H, Liebers V, Deckert A, Bruning T, et al. Airway and Blood Inflammatory Markers in Waste Collectors. Adv Exp Med Biol. 2017;1021:1-14 pubmed publisher
    ..The study aim was to evaluate inflammatory processes in blood and in the respiratory tract via analysis of atopy and club cell secretory protein 16 (CC16) in serum, exhaled nitric oxide (FeNO), and cellular and soluble ..
  39. Sinz H, Renz H, Skevaki C. Cellular and noncellular bloodborne biomarkers in asthma. Ann Allergy Asthma Immunol. 2017;118:672-679 pubmed publisher
    ..article summarizes the association of various blood biomarkers with the type of airway inflammation, presence of atopy, and dominance of specific T-cell subsets and associated pathways in asthma...
  40. Bedolla Barajas M, Machuca Rincón M, Morales Romero J, Macriz Romero N, Madrigal Beas I, Robles Figueroa M, et al. [Self-reported prevalence of latex allergy and associated factors in healthcare workers]. Rev Alerg Mex. 2017;64:430-438 pubmed
    ..68; 95 % CI: 1.03-2.73, p = 0.037), personal history of atopy (OR = 4.82; 95 % CI: 3.19-7.26, p < 0.0001), family history of atopic dermatitis (OR = 4.33, 95 % CI: 1.20-4...
  41. Kitcharoensakkul M, Bacharier L, Yin DeClue H, Boomer J, Burgdorf D, Wilson B, et al. Temporal biological variability in dendritic cells and regulatory T cells in peripheral blood of healthy adults. J Immunol Methods. 2016;431:63-5 pubmed publisher
    ..74, and 0.82, respectively. There were no significant changes in ICC (<0.1) after adjusting for age, gender and atopy except for IL-4. Substantial variability for iTregs was determined for the control condition (PBS with IL-2)...
  42. Sancakli O, Yenigun A, Gültekin Korkmazgil B, Tuncel T. Comparison of diagnostic tests for suspected cow's milk allergy in children with atopic dermatitis. Minerva Pediatr. 2016;: pubmed
    ..Documentation of the efficacies of specific IgE(sIgE), skin prick test(SPT),and atopy patch test(APT) are important for determining the necessity of oral food challenge tests(OFC)...
  43. Nigro E, Brini A, Yenagi V, Ferreira L, Achatz Straussberger G, Ambrosi A, et al. Cutting Edge: IgE Plays an Active Role in Tumor Immunosurveillance in Mice. J Immunol. 2016;197:2583-8 pubmed publisher
    ..Our findings provide the rationale for clinical observations that relate atopy with a lower risk for developing cancer and open new avenues for the design of immunotherapeutics relevant for ..
  44. Fuchs O, Gorlanova O, Latzin P, Schmidt A, Schieck M, Toncheva A, et al. 6q12 and 11p14 variants are associated with postnatal exhaled nitric oxide levels and respiratory symptoms. J Allergy Clin Immunol. 2017;140:1015-1023 pubmed publisher
    ..levels might implicate that postnatal eNO metabolism in healthy infants before first viral infections and sensitization is related to mechanisms other than those associated with asthma, atopy, or increased risk thereof later in life.
  45. Erdem S, Can D, Girit S, Catal F, Sen V, Pekcan S, et al. Does atopy affect the course of viral pneumonia?. Allergol Immunopathol (Madr). 2018;46:119-126 pubmed publisher
    The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia...
  46. Zolkipli Z, Roberts G, Cornelius V, Clayton B, Pearson S, Michaelis L, et al. Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood. J Allergy Clin Immunol. 2015;136:1541-1547.e11 pubmed publisher
    ..placebo-controlled, proof-of-concept study involving 111 infants less than 1 year of age at high risk of atopy (≥ 2 first-degree relatives with allergic disease) but with negative skin prick test responses to common ..
  47. Lecouffe Desprets M, Groh M, Bour B, Le Jeunne C, Puéchal X. Eosinophilic gastrointestinal disorders associated with autoimmune connective tissue disease. Joint Bone Spine. 2016;83:479-84 pubmed publisher
    ..No patient had a history of atopy. In contrast with classical EGID among which eosinophilic esophagitis is the most frequent type, eosinophilic ..
  48. House J, Wyss A, Hoppin J, Richards M, Long S, Umbach D, et al. Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study. J Allergy Clin Immunol. 2017;140:249-256.e14 pubmed publisher
    ..We sought to examine associations between early-life farming exposures and current asthma and atopy in an older adult US farming population...
  49. Massetti G, Thomas C, Ragan K. Disparities in the Context of Opportunities for Cancer Prevention in Early Life. Pediatrics. 2016;138:S65-S77 pubmed
    ..pubertal timing; exposure to radiation; exposure to tobacco in utero and in early life; allergies, asthma, and atopy; and early exposure to infection...
  50. Avdeeva K, Fokkens W. Precision Medicine in Chronic Rhinosinusitis with Nasal Polyps. Curr Allergy Asthma Rep. 2018;18:25 pubmed publisher
    ..of rhinitis and chronic rhinosinusitis (CRS) have been described based on symptom severity and duration, atopy status, level of control, comorbidities, and presence or absence of nasal polyps in CRS...
  51. Lee Y, Gilliland F, Wang J, Lee Y, Guo Y. Associations of FcepsilonRIbeta E237G polymorphism with wheezing in Taiwanese schoolchildren. Clin Exp Allergy. 2008;38:413-20 pubmed publisher
    ..The FcepsilonRIbeta E237G allele may have a protective role in wheezing illness among Taiwanese schoolchildren, depending on airway oxidative stress levels. ..
  52. Ribas T, Pipe Martin H, Kim K, Leissinger M, Bauer R, Grasperge B, et al. Fungal myocarditis and pericardial effusion secondary to Inonotus tropicalis (phylum Basidiomycota) in a dog. J Vet Cardiol. 2015;17:142-8 pubmed publisher
    ..female spayed French bulldog with a multi-year history of treatment with glucocorticoids for management of atopy was presented for exercise intolerance, ascites and weight loss...
  53. Smith Norowitz T, Saadia T, Banniettis N, Norowitz Y, Joks R, Hammerschlag M, et al. IgE anti-Haemophilus influenzae type b (Hib) antibodies detected in serum of Hib-vaccinated asthmatic and non-asthmatic pediatric patients. Minerva Pediatr. 2018;70:111-116 pubmed publisher
    ..the relationship between Hib vaccination and diseases of altered immunoglobulin E (IgE) regulation (asthma or atopy)...
  54. Yang I, Pedersen B, Liu A, O Connor G, Pillai D, Kattan M, et al. The nasal methylome and childhood atopic asthma. J Allergy Clin Immunol. 2017;139:1478-1488 pubmed publisher
    ..Genes differentially methylated included those with established roles in asthma and atopy and genes related to extracellular matrix, immunity, cell adhesion, epigenetic regulation, and airflow obstruction...
  55. Igetei J, El Faham M, Liddell S, Doenhoff M. Antigenic cross-reactivity between Schistosoma mansoni and peanut: a role for cross-reactive carbohydrate determinants (CCDs) and implications for the hygiene hypothesis. Immunology. 2017;150:506-517 pubmed publisher
    ..organisms provided a possible explanation for the negative correlation between chronic schistosome infection and atopy to allergens...
  56. Ozturk A, Bayraktar R, Gogebakan B, Mumbuc S, Bayram H. Comparison of inflammatory cytokine release from nasal epithelial cells of non-atopic non-rhinitic, allergic rhinitic and polyp subjects and effects of diesel exhaust particles in vitro. Allergol Immunopathol (Madr). 2017;45:473-481 pubmed publisher
    ..A limited number of studies have suggested that diesel exhaust particles (DEP) play a role in atopy and the pathogenesis of allergic upper airway diseases...
  57. Pitt T, Becker A, Chan Yeung M, Chan E, Watson W, Chooniedass R, et al. Reduced risk of peanut sensitization following exposure through breast-feeding and early peanut introduction. J Allergy Clin Immunol. 2017;: pubmed publisher
    ..6%). Interaction analyses controlling for study group and maternal atopy confirmed that maternal peanut consumption while breast-feeding and infant peanut consumption by 12 months were ..
  58. Ozceker D, Bulut M, Ozbay A, Dilek F, Koser M, Tamay Z, et al. Assessment of IL-31 levels and disease severity in children with atopic dermatitis. Allergol Immunopathol (Madr). 2018;46:322-325 pubmed publisher
    ..Data on demographic features (age, gender, family history of atopy) and laboratory values of serum eosinophil, total IgE, IgM, IgA, IgG levels and skin prick test results were ..
  59. Kim S, Bae J, Holloway J, Lee J, Suh C, Nahm D, et al. A polymorphism of MS4A2 (- 109T > C) encoding the beta-chain of the high-affinity immunoglobulin E receptor (FcepsilonR1beta) is associated with a susceptibility to aspirin-intolerant asthma. Clin Exp Allergy. 2006;36:877-83 pubmed
    ..The MS4A2 gene, the beta chain of the high-affinity receptor for immunoglobulin (Ig)E, has previously been linked to atopy and asthma...
  60. Hu Y, Xiao Zhang -, Zhao D, Guo H, Fu L, Guo L, et al. Tuning the structures based on polyoxometalates from 1-D to 2-D by using different secondary organic ligands. Dalton Trans. 2015;44:14830-41 pubmed publisher
    ..5H2O () (pic = deprotonated picolinic acid, apy = 2-aminopyridine, 2,2'-bpy = 2,2'-bipyridine, phen = phenanthroline), have been synthesized and characterized by ..
  61. Shein S, Rotta A, Speicher R, Slain K, Gaston B. Corticosteroid Therapy During Acute Bronchiolitis in Patients Who Later Develop Asthma. Hosp Pediatr. 2017;7:403-409 pubmed publisher
    ..However, risk factors for asthma such as eczema or familial atopy prompt some practitioners to prescribe corticosteroids for bronchiolitis...
  62. Cooper P, Chico M, Vaca M, Sandoval C, Loor S, Amorim L, et al. Effect of Early Life Geohelminth Infections on the Development of Wheezing at 5 Years of Age. Am J Respir Crit Care Med. 2017;: pubmed publisher
    Exposures to geohelminths during gestation or early childhood may reduce risk of wheezing illness/asthma and atopy during childhood in tropical regions...
  63. Takeuchi K, Abe S, Masuda S, Yuta A, Majima Y, Sakakura Y. Lack of association between gene polymorphism of transporters associated with antigen processing and allergic rhinitis in a Japanese population. Ann Otol Rhinol Laryngol. 2002;111:460-3 pubmed
    ..It has been reported that polymorphisms in the TAP1 gene are associated with atopy in Tunisians...
  64. Moawad F, Dellon E, Achem S, Ljuldjuraj T, Green D, Maydonovitch C, et al. Effects of Race and Sex on Features of Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 2016;14:23-30 pubmed publisher
    ..012). Males and females had similar clinical presentations, histories of atopy, findings from endoscopy, and histologic characteristics...
  65. Weidinger S, Novak N. Atopic dermatitis. Lancet. 2016;387:1109-1122 pubmed publisher
    ..We need to improve understanding of the heterogeneity of the disease and its subtypes, the role of atopy and autoimmunity, the mechanisms behind disease-associated itch, and the comparative effectiveness and safety of ..
  66. Macías Robles A, Morán Mendoza A. [Latex sensitization prevalence through prick test in patients with genitourinary malformations and more than 3 surgeries]. Rev Alerg Mex. 2016;63:154-62 pubmed
    ..The study exposed prevalence of 30.72%. Related to associated factors as follows: atopy (p=0.047), previous antecedent reaction to latex products (p=0.003) specific for balloons (p=0...
  67. Choi J, Kim S, Suh C, Nahm D, Park H. Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema. J Korean Med Sci. 2005;20:367-72 pubmed
    ..Eleven single nucleotide polymorphisms (SNPs) of the beta chain of the high-affinity IgE receptor (FCER1B) and three histamine-related genes-histamine N-methyltransferase (HNMT), histamine H1 receptor (HRH1), histamine ..
  68. Norbäck D, Cai G, Kreft I, Lampa E, Wieslander G. Fungal DNA in dust in Swedish day care centres: associations with respiratory symptoms, fractional exhaled nitrogen oxide (FeNO) and C-reactive protein (CRP) in serum among day care centre staff. Int Arch Occup Environ Health. 2016;89:331-40 pubmed publisher
    ..dyspnoea ratings were log-transformed, and associations were analysed by linear mixed models, adjusting for age, atopy, smoking, body mass index (BMI), ETS and dampness/mould at home. Geometric mean (GM) for FeNO was 15...
  69. Ostersen T, Christensen O, Madsen P, Henryon M. Sparse single-step method for genomic evaluation in pigs. Genet Sel Evol. 2016;48:48 pubmed publisher
    ..A recently proposed algorithm for proven and young animals (APY) is an approximation that reduces computing time drastically by dividing genotyped animals into core and non-core ..
  70. Hose A, Depner M, Illi S, Lau S, Keil T, Wahn U, et al. Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts. J Allergy Clin Immunol. 2017;139:1935-1945.e12 pubmed publisher
    Phenotypes of childhood-onset asthma are characterized by distinct trajectories and functional features. For atopy, definition of phenotypes during childhood is less clear...
  71. Álvarez Zallo N, Aguinaga Ontoso I, Alvarez Alvarez I, Guillen Grima F, Azcona San Julián C. The influence of gender and atopy in the relationship between obesity and asthma in childhood. Allergol Immunopathol (Madr). 2017;45:227-233 pubmed publisher Spanish children and adolescents and to determine whether this relationship was affected by gender and atopy. The study involves 8607 Spanish children and adolescents from the International Study of Asthma and Allergies in ..
  72. Mazur A, Szylling A, Bielecka T, Strzelak A, Kulus M. Is the "farm effect" hypothesis still current? Atopy and allergic diseases in rural and urban children in Poland. J Asthma. 2017;:1-9 pubmed publisher
    ..Although farm-living has been associated with a lower prevalence of asthma and atopy, a marked increase in atopy among rural populations after accession to the European Union has been recently ..
  73. Brutsche M, Brutsche I, Wood P, Mogulkoc N, Custovic A, Egan J, et al. B-cell isotype control in atopy and asthma assessed with cDNA array technology. Am J Physiol Lung Cell Mol Physiol. 2001;280:L627-37 pubmed
    ..The aim of the study was to investigate human B-cell isotype control and IgE production in atopy and asthma with cDNA array technology...
  74. Nagata H, Mutoh H, Kumahara K, Arimoto Y, Tomemori T, Sakurai D, et al. Association between nasal allergy and a coding variant of the Fc epsilon RI beta gene Glu237Gly in a Japanese population. Hum Genet. 2001;109:262-6 pubmed
    ..beta-chain of the high-affinity receptor for IgE (Fc epsilon RI beta) has been proposed as a candidate gene for atopy. A coding variant Glu237Gly has been studied in various populations with asthma and atopy, and the results were ..
  75. Guilbert T, Krawiec M. Natural history of asthma. Pediatr Clin North Am. 2003;50:523-38 pubmed
    ..These children typically have a family history of asthma and demonstrate increased airways reactivity and atopy in childhood...
  76. Kraft S, Rana S, Jouvin M, Kinet J. The role of the FcepsilonRI beta-chain in allergic diseases. Int Arch Allergy Immunol. 2004;135:62-72 pubmed
    ..In addition, the genomic region encompassing the beta-chain has been linked to atopy and a number of polymorphisms within the FcepsilonRIbeta gene are associated with various atopic diseases...
  77. Saadeh D, Salameh P, Caillaud D, Charpin D, De Blay F, Kopferschmitt C, et al. Prevalence and association of asthma and allergic sensitization with dietary factors in schoolchildren: data from the french six cities study. BMC Public Health. 2015;15:993 pubmed publisher
    ..However, prospective and experimental studies are needed to provide causal evidence concerning the effect of diet on asthma and atopy.
  78. Stelmach I, Cichalewski Å, Majak P, Smejda K, Podlecka D, JerzyÅ„ska J, et al. School environmental factors are predictive for exercise-induced symptoms in children. Respir Med. 2016;112:25-30 pubmed publisher
    ..reported symptoms induced during PE lesson were invited to the clinic for ETC (exercise treadmill challenge) and atopy measurement. 1033 participants were included into the analysis. Sixty seven(6...
  79. Roine J, Uusitalo L, Hielm Björkman A. Validating and reliability testing the descriptive data and three different disease diagnoses of the internet-based DOGRISK questionnaire. BMC Vet Res. 2016;12:30 pubmed publisher
    ..37. Of the owners contacted by email/mail to confirm their dog's atopy/allergy (skin symptoms), 8...
  80. Mentzer A, Nayee S, Omar Y, Hullah E, Taylor K, Goel R, et al. Genetic Association Analysis Reveals Differences in the Contribution of NOD2 Variants to the Clinical Phenotypes of Orofacial Granulomatosis. Inflamm Bowel Dis. 2016;22:1552-8 pubmed publisher
    ..The etiology remains largely unknown, although there is a high prevalence of atopy, and oral granulomas are also seen in other immune disorders particularly CD and sarcoidosis...
  81. Lyons J, Milner J. Primary atopic disorders. J Exp Med. 2018;215:1009-1022 pubmed publisher
    ..The pathways identified as critical in the development of atopy range from focal defects in immune cells and epithelial barrier function to global changes in metabolism...
  82. Wilson B, Pfeiffer J, Oliver J. FcepsilonRI signaling observed from the inside of the mast cell membrane. Mol Immunol. 2002;38:1259-68 pubmed
  83. Cui T, Wang L, Wu J, Xie J. The association analysis of FcepsilonRIbeta with allergic asthma in a Chinese population. Chin Med J (Engl). 2003;116:1875-8 pubmed
    ..The -109C/T and Glu237Gly polymorphisms are two of the genetic factor identified thus far, which affect total plasma IgE levels of allergic asthma patients in a Chinese population. ..
  84. Maier L, Howson J, Walker N, Spickett G, Jones R, Ring S, et al. Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. J Allergy Clin Immunol. 2006;117:1306-13 pubmed
    ..polymorphisms in 8 genes that are candidate susceptibility loci for IgE levels/atopic illness (IL13, IL4, IL4RA, FCER1B, IL12B, TBET) and/or type 1 diabetes (CTLA4, PTPN22, IL2RA)...
  85. Sharma S, Ghosh B. Promoter polymorphism in the MS4A2 gene and asthma in the Indian population. Int Arch Allergy Immunol. 2009;149:208-18 pubmed publisher
    A previous study from our laboratory identified 3-locus risk and protective haplotypes of the MS4A2 gene, a prime candidate for asthma and atopy, that were associated with differential histamine release profiles from basophils and ..
  86. Min K, Kwon H, Kim K, Kim S. Air Pollution Monitoring Design for Epidemiological Application in a Densely Populated City. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..representing various pollution sources at the regulatory monitoring sites, 31,097 children's homes from the Atopy Free School survey, and 412 community service centers in Seoul...
  87. Gupta M, Sicherer S. Timing of food introduction and atopy prevention. Clin Dermatol. 2017;35:398-405 pubmed publisher
    ..Early advice to have atopy-prone infants delay ingestion of potential food allergens, such as egg, cow's milk, and peanut, was rescinded, as ..
  88. Sellitto A, De Fanis U, Balestrieri A, Savoia A, Astarita C, Romano C. Effects of omalizumab treatment on serum cytokine concentrations of atopic patients with chronic spontaneous urticaria: a preliminary report. Eur Ann Allergy Clin Immunol. 2017;49:171-175 pubmed
    ..Besides, a proportion of chronic spontaneous urticaria patients have concomitant atopy, which may be associated, at least in theory, with prevalence of serum Th2-type cytokines...
  89. Sugier P, Brossard M, Sarnowski C, Vaysse A, Morin A, Pain L, et al. A novel role for ciliary function in atopy: ADGRV1 and DNAH5 interactions. J Allergy Clin Immunol. 2018;141:1659-1667.e11 pubmed publisher
    b>Atopy, an endotype underlying allergic diseases, has a substantial genetic component. Our goal was to identify novel genes associated with atopy in asthma-ascertained families...
  90. Gonzaga T, Alves F, Cheik M, de Barros C, Rezende E, Segundo G. Low efficacy of atopy patch test in predicting tolerance development in non-IgE-mediated cow's milk allergy. Allergol Immunopathol (Madr). 2018;46:241-246 pubmed publisher
    The food atopy patch (APT) test has been used in previous studies to help the diagnosis of non-IgE mediated food allergies (FA)...
  91. Wild P, Mével H, Penven E, Zmirou Navier D, Barbaud A, Bohadana A, et al. FeNO levels increase with degree of sensitisation in apprentices at risk of occupational asthma. Int J Tuberc Lung Dis. 2017;21:1194-1200 pubmed publisher
    b>Atopy has emerged as a major determinant of airway inflammation.
  92. Fang Mercado L, Urrego Álvarez J, Merlano Barón A, Meza Torres C, Hernández Bonfante L, López Kleine L, et al. [Influence of lifestyle, diet and vitamin D on atopy in a population of Afro-descendant Colombian children]. Rev Alerg Mex. 2017;64:277-290 pubmed
    ..Lifestyle and diet were established by questionnaires, atopy was assessed with skin tests and total and specific IgE and vitamin D levels were determined by ELISA...