MRP4

Summary

Gene Symbol: MRP4
Description: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Alias: EST170205, MOAT-B, MOATB, MRP4, ATP-binding cassette sub-family C member 4, MRP/cMOAT-related ABC transporter, bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4), canalicular multispecific organic anion transporter (ABC superfamily), multi-specific organic anion transporter B, multidrug resistance-associated protein 4, multispecific organic anion transporter B
Species: human

Top Publications

  1. ncbi Stimulation of cyclic GMP efflux in human melanocytes by hypergravity generated by centrifugal acceleration
    Krassimira Ivanova
    Institute of Aerospace Medicine, German Aerospace Center, Linder Hohe, 51170, Cologne, Germany
    Pigment Cell Res 17:471-9. 2004
  2. ncbi Multidrug resistance-associated proteins 3, 4, and 5
    Piet Borst
    Division of Molecular Biology and Center of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Pflugers Arch 453:661-73. 2007
  3. pmc Effect of hypouricaemic and hyperuricaemic drugs on the renal urate efflux transporter, multidrug resistance protein 4
    A A K El-Sheikh
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Br J Pharmacol 155:1066-75. 2008
  4. doi Multidrug resistance-associated proteins and implications in drug development
    Ya He Liu
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Melbourne, Victoria 3083, Australia
    Clin Exp Pharmacol Physiol 37:115-20. 2010
  5. ncbi [Molecular cloning and functional characterization of a novel gene encoding human prostaglandin carrier, hPrC]
    Yasuna Kobayashi
    Department of Clinical Pharmacy, School of Pharmacy, Showa University, Tokyo, Japan
    Yakugaku Zasshi 131:1493-501. 2011
  6. ncbi Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro
    Murray D Norris
    Children s Cancer Institute Australia for Medical Research, University of Sydney, Sydney, Australia
    Mol Cancer Ther 4:547-53. 2005
  7. ncbi ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4)
    Maria Rius
    Division of Tumor Biochemistry, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Pharmacol Exp Ther 324:86-94. 2008
  8. doi Non-steroidal anti-inflammatory drugs increase the antiretroviral activity of nucleoside reverse transcriptase inhibitors in HIV type-1-infected T-lymphocytes: role of multidrug resistance protein 4
    Ma Isabel Clemente
    Laboratory Inmuno Biologia Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Antivir Ther 14:1101-11. 2009
  9. doi Molecular interaction between HAX-1 and XIAP inhibits apoptosis
    Young Ji Kang
    Medical Proteomics Research Center, KRIBB, Daejeon 305 806, Republic of Korea
    Biochem Biophys Res Commun 393:794-9. 2010
  10. ncbi Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells
    Peter R Wielinga
    Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
    J Biol Chem 278:17664-71. 2003

Research Grants

Detail Information

Publications179 found, 100 shown here

  1. ncbi Stimulation of cyclic GMP efflux in human melanocytes by hypergravity generated by centrifugal acceleration
    Krassimira Ivanova
    Institute of Aerospace Medicine, German Aerospace Center, Linder Hohe, 51170, Cologne, Germany
    Pigment Cell Res 17:471-9. 2004
    ..of 1 microM trequinsin, an inhibitor of cGMP-binding PDE (PDE5) and of transport by multidrug resistance proteins MRP4/5, whereas 50 microM trequinsin partially inhibited cGMP transport...
  2. ncbi Multidrug resistance-associated proteins 3, 4, and 5
    Piet Borst
    Division of Molecular Biology and Center of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Pflugers Arch 453:661-73. 2007
    ..The function of MRP3 in other tissues, notably the gut and the adrenal cortex, remains to be defined. MRP4 and MRP5 have attracted attention by their ability to transport cyclic nucleotides and many nucleotide analogs...
  3. pmc Effect of hypouricaemic and hyperuricaemic drugs on the renal urate efflux transporter, multidrug resistance protein 4
    A A K El-Sheikh
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Br J Pharmacol 155:1066-75. 2008
    ..Recently, we identified the multidrug resistance protein (MRP) 4 as a luminal efflux transporter for urate in the proximal tubule...
  4. doi Multidrug resistance-associated proteins and implications in drug development
    Ya He Liu
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Melbourne, Victoria 3083, Australia
    Clin Exp Pharmacol Physiol 37:115-20. 2010
    ..3. Both MRP4 and MRP5 are able to mediate the transport of cyclic nucleotides and confer resistance to certain antiviral and ..
  5. ncbi [Molecular cloning and functional characterization of a novel gene encoding human prostaglandin carrier, hPrC]
    Yasuna Kobayashi
    Department of Clinical Pharmacy, School of Pharmacy, Showa University, Tokyo, Japan
    Yakugaku Zasshi 131:1493-501. 2011
    ..Although there are several PG transporters such as multidrug resistance-associated protein 4 (MRP4), organic cation transporter 1 (OCT1) [solute carrier (SLC) 22A1], organic anion transporter 1-3 (OAT1-3) [SLC22A6-..
  6. ncbi Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro
    Murray D Norris
    Children s Cancer Institute Australia for Medical Research, University of Sydney, Sydney, Australia
    Mol Cancer Ther 4:547-53. 2005
    ..We observed frequent MRP4 overexpression in aggressive primary neuroblastoma, a disease for which we have previously shown MRP1 to be a ..
  7. ncbi ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4)
    Maria Rius
    Division of Tumor Biochemistry, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Pharmacol Exp Ther 324:86-94. 2008
    ..Thus, as an efflux pump for the proinflammatory mediators LTB(4) and LTC(4), ABCC4 may represent a novel target for anti-inflammatory therapies...
  8. doi Non-steroidal anti-inflammatory drugs increase the antiretroviral activity of nucleoside reverse transcriptase inhibitors in HIV type-1-infected T-lymphocytes: role of multidrug resistance protein 4
    Ma Isabel Clemente
    Laboratory Inmuno Biologia Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Antivir Ther 14:1101-11. 2009
    ..b>MRP4 has been reported to transport antiretroviral drugs out of cells in an active process...
  9. doi Molecular interaction between HAX-1 and XIAP inhibits apoptosis
    Young Ji Kang
    Medical Proteomics Research Center, KRIBB, Daejeon 305 806, Republic of Korea
    Biochem Biophys Res Commun 393:794-9. 2010
    ....
  10. ncbi Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells
    Peter R Wielinga
    Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
    J Biol Chem 278:17664-71. 2003
    ..Two recently described members of the multidrug resistance protein family, MRP4 and MRP5, might be involved in this process, because they transport the 3',5'-cyclic nucleotides, cAMP and cGMP, ..
  11. pmc Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4)
    Noam Zelcer
    Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochem J 371:361-7. 2003
    ..Recently, it has been shown that Mrp4 is induced in the livers of Fxr ((-/-)) mice, which have increased levels of serum bile acids...
  12. ncbi Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing
    Masashi Adachi
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 277:38998-9004. 2002
    The multidrug resistance protein MRP4, a member of the ATP-binding cassette superfamily, confers resistance to purine-based antiretroviral agents. However, the antiviral agent ganciclovir (GCV) has not been shown to be a substrate of MRP4...
  13. pmc Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5)
    Chung Pu Wu
    Department of Pharmacology, University of Cambridge, UK
    FEBS J 272:4725-40. 2005
    ..resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5...
  14. pmc The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
    Glen Reid
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 100:9244-9. 2003
    ..In inside-out membrane vesicles derived from insect cells or HEK293 cells, MRP4 catalyzed the time- and ATP-dependent uptake of prostaglandin E1 (PGE1) and PGE2...
  15. ncbi Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development
    Shu Feng Zhou
    Division of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, Victoria, Australia
    Curr Med Chem 15:1981-2039. 2008
    ..ABC) transporter genes and the multidrug resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3, MRP4/ABCC4, MRP5/ABCC5, MRP6/ABCC6, MRP7/ABCC10, MRP8/ABCC11 and MRP9/ABCC12) belong to the ABCC family which contains ..
  16. pmc Prominent expression of xenobiotic efflux transporters in mouse extraembryonic fetal membranes compared with placenta
    Lauren M Aleksunes
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Drug Metab Dispos 36:1960-70. 2008
    ..At days 14 and 17, fetal membranes expressed higher mRNA levels of the efflux transporters Mrp2 (7-fold), Mrp4 (5-fold), Mrp5 (3-fold), Mrp6 (12-fold), Bcrp (2-fold), and Mate-1 (7-fold) than placenta...
  17. ncbi Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis
    Lisa D Beilke
    Department of Pharmacology and Toxicology, College of Pharmacy, University Animal Care, University of Arizona, Tucson 85721, USA
    Toxicol Sci 102:196-204. 2008
    ..of uptake transporters Ntcp and Oatp4 was significantly increased, as were sinusoidal efflux transporters Mrp3 and Mrp4. Although in PB/LCA cotreated mice, the only significant change compared with LCA-only treatment was an increase in ..
  18. ncbi Modulators of multidrug resistance associated proteins in the management of anticancer and antimicrobial drug resistance and the treatment of inflammatory diseases
    An Kui Yang
    Department of Head and Neck Surgery, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Curr Top Med Chem 10:1732-56. 2010
    ..Both PGE(1) and PGE(2) are known high-affinity substrates of MRP4, but not MRP1, MRP2, MRP3 and MRP5. LTC(4) is a substrate of MRP1, MRP2, MRP3, and MRP6-8...
  19. ncbi Influence of acetaminophen vehicle on regulation of transporter gene expression during hepatotoxicity
    Lauren M Aleksunes
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269 3092, USA
    J Toxicol Environ Health A 70:1870-2. 2007
    ..In contrast, multidrug resistance-associated proteins Mrp1, Mrp2, Mrp3, and Mrp4, as well as multidrug resistance proteins Mdr1a and Mdr1b genes, were increased following APAP...
  20. ncbi The combination of glycyrrhizin and lamivudine can reverse the cisplatin resistance in hepatocellular carcinoma cells through inhibition of multidrug resistance-associated proteins
    Takahiro Wakamatsu
    Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan
    Int J Oncol 31:1465-72. 2007
    ..1-fold higher resistance to cisplatin, and they expressed higher levels of MRP2 (6.29-fold), MRP3 (3.2-fold), MRP4 (11.3-fold) and MRP5 (3.39-fold) mRNAs than the wild-type cells by using real-time PCR...
  21. pmc Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function
    Sarah N Campion
    Dept of Pharmaceutical Sciences, Univ of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, CT 06269 3092, USA
    Am J Physiol Gastrointest Liver Physiol 295:G294-304. 2008
    ..b>Mrp4 is the most significantly upregulated transporter in mouse liver following APAP treatment...
  22. ncbi Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway
    Jonathan M Maher
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
    Hepatology 46:1597-610. 2007
    ..liver, Mrp2 transports bilirubin-glucuronide, glutathione (GSH), and drug conjugates into bile, whereas Mrp3 and Mrp4 efflux these entities into blood...
  23. pmc MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver
    M G Belinsky
    Division of Medical Sciences, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Br J Cancer 80:1342-9. 1999
    ..We previously reported the isolation of three human MRP/cMOAT-related transporters, MOAT-B (MRP4), MOAT-C (MRP5) and MOAT-D (MRP3). In the present study we describe the fourth MRP/cMOAT-related transporter...
  24. ncbi Gender differences in mRNA expression of ATP-binding cassette efflux and bile acid transporters in kidney, liver, and intestine of 5/6 nephrectomized rats
    Hong Lu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Drug Metab Dispos 36:16-23. 2008
    ..Renal protein expression of Mrp2 increased, whereas that of Mrp4 remained unchanged in both genders of Nx rats...
  25. doi Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity
    Qiuqiong Cheng
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, USA
    Mol Pharm 5:77-91. 2008
    ..multidrug resistance-associated proteins (Mrps) was increased in livers of ob/ob mice, particularly with Mrp4 expression being elevated by at least 6-fold and Mrp2 expression at least 3-fold in livers of ob/ob mice...
  26. pmc Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity
    Jin Kyung Lee
    School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7360, USA
    Toxicol Appl Pharmacol 228:17-23. 2008
    ..blot analysis demonstrated increased levels of CYP3A1/2 and Mrp2 in SCRH pretreated with DEX; interestingly, Mrp4 expression was increased in SCRH after BSO exposure...
  27. ncbi Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2, MRP3, MRP4, MRP5, and SMRP in childhood acute myeloid leukemia
    Daniel Steinbach
    University Children s Hospital, 07740 Jena, Germany
    Clin Cancer Res 9:1083-6. 2003
    ..Their structure, function, and substrate specificity have been studied intensively, but little is known about their clinical relevance in malignant diseases...
  28. ncbi Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins
    M G Belinsky
    Division of Medical Sciences, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Natl Cancer Inst 90:1735-41. 1998
    ..To further define the MRP/cMOAT subfamily of transporters, we used EST probes to isolate complementary DNAs for two related transporter proteins, MOAT-C and MOAT-D...
  29. doi Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil
    Praveen K Nambaru
    Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University, Greifswald, Germany
    Drug Metab Dispos 39:132-9. 2011
    ..Expression of MRP1, MRP3, MRP4, and MRP5 in human pancreas and pancreatic carcinoma has been reported...
  30. ncbi Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells
    M Kool
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Cancer Res 59:175-82. 1999
    ..cMOAT or MRP2, encoding the canalicular multispecific organic anion transporter; and four homologues, called MRP3, MRP4, MRP5, and MRP6. The most recently discovered member of the family, MRP6, is analyzed in this report...
  31. ncbi Molecular and functional MDR1-Pgp and MRPs expression in human glioblastoma multiforme cell lines
    Xavier Declèves
    INSERM U26, Hôpital F Widal, Paris, France
    Int J Cancer 98:173-80. 2002
    ..Three other MRPs (MRP3, MRP4 and MRP5) were detected by RT-PCR in both cell lines, whereas MRP2 was not expressed...
  32. pmc Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment
    Lauren M Aleksunes
    University of Connecticut, Department of Pharmaceutical Sciences, 69 North Eagleville Road, U 3092 Storrs, CT 06269 3092, United States
    Toxicology 250:82-8. 2008
    ..Cisplatin-induced renal injury increased mRNA and protein levels of the efflux transporters Mrp2, Mrp4, Mrp5, Mdr1a and Mdr1b. Uptake transporters Oatp2a1 and Oatp2b1 mRNA were also up-regulated following cisplatin...
  33. ncbi The multidrug resistance-associated protein 3 (MRP3) is associated with a poor outcome in childhood ALL and may account for the worse prognosis in male patients and T-cell immunophenotype
    Daniel Steinbach
    Klinikum der FSU Jena, Klinik fur Kinder und Jugendmedizin, Postfach, 07740 Jena, Germany
    Blood 102:4493-8. 2003
    ..In this study the expression of the MRP2, MRP3, MRP4, MRP5, and SMRP genes was measured using TaqMan real-time polymerase chain reaction (PCR) in 103 children with ..
  34. ncbi Renal and hepatic transporter expression in type 2 diabetic rats
    Michael T Nowicki
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Road, Storrs, CT 06269 3092, USA
    Drug Metab Lett 2:11-7. 2008
    ..3-fold) and decreased levels of Oct2 to 50% of control kidneys. Conversely, efflux transporters Mrp2, Mrp4, and Bcrp were increased 5.4-fold, 2-fold, and 1...
  35. doi Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells
    Rebekka A Hannivoort
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 48:624-34. 2008
    ..With respect to hepatocytes, activated HSCs expressed high levels of Mrp1 and comparable levels of Mrp3, Mrp4, Mdr1a, and Mdr1b but not the hepatocyte-specific transporters bile salt export pump, Mrp2, and Mrp6...
  36. ncbi The potential impact of drug transporters on nucleoside-analog-based antiviral chemotherapy
    P Borst
    Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Antiviral Res 62:1-7. 2004
    ..work has shown that at least three members of the family of human Multidrug Resistance-associated Proteins (MRPs), MRP4, 5 and 8, are able to transport some nucleoside-monophosphate analogs...
  37. ncbi Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney
    Lei Ci
    Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Mol Pharmacol 71:1591-7. 2007
    The purpose of the present study was to investigate the role of multidrug resistance-associated protein 4 (MRP4) in the tubular secretion of cephalosporin antibiotics...
  38. doi Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation
    L M Roberts
    XenoPort, Inc, 3410 Central Expressway, Santa Clara, CA 95051, USA
    Neuroscience 155:423-38. 2008
    ..Lat1, Mrp1 and Mrp4 were detected on the basal-lateral surface of lateral ventricle choroid plexus epithelial cells...
  39. ncbi Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter
    Pascal H E Smeets
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    J Am Soc Nephrol 15:2828-35. 2004
    ..1 +/- 0.6 mM). Human MRP4 (ABCC4), which has recently been localized to the apical membrane, expressed in Sf9 cells had a much higher ..
  40. ncbi Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids
    Gernot Zollner
    Laboratory of Experimental and Molecular Hepatology, Div of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz 15, Graz A 8036, Austria
    Am J Physiol Gastrointest Liver Physiol 290:G923-32. 2006
    ..b>Mrp4 induction in the liver and kidney correlated with bile acid levels and was observed in UDCA-fed and CA-fed FXR(-/-) ..
  41. pmc Drug transporter expression and localization in rat nasal respiratory and olfactory mucosa and olfactory bulb
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Drug Metab Dispos 38:1644-7. 2010
    ..OCT)1, 2, and 3; OCTN1; organic anion-transporting polypeptide (OATP)3; and multidrug resistance (MRP)1 and MRP4] in nasal respiratory mucosa, olfactory mucosa, and olfactory bulb to the level of expression of these transporters ..
  42. ncbi Hepatobiliary transporter expression in intercellular adhesion molecule 1 knockout and Fas receptor-deficient mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress
    Martin Wagner
    Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Drug Metab Dispos 35:1694-9. 2007
    ..Mrp3 was moderately induced in ICAM(-/-), lpr, and endotoxin-resistant mice, whereas Mrp4 was only induced in the endotoxin-resistant strain...
  43. ncbi Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta
    Marc Le Vee
    Institut National de la Santé et de la Recherche Médicale U620, Faculty of Pharmacy, Rennes, France
    Drug Metab Dispos 36:217-22. 2008
    ..polypeptide (OATP)-B, OATP-C, and OATP8 and the efflux pumps multidrug resistance-associated protein (MRP) 2, MRP3, MRP4, and breast cancer resistance protein were also down-regulated at mRNA levels in human hepatocytes treated by IL-..
  44. ncbi P2Y1 and cysteinyl leukotriene receptors mediate purine and cysteinyl leukotriene co-release in primary cultures of rat microglia
    P Ballerini
    Department of Biomedical Sciences, G D Annunzio University of Chieti, Italy
    Int J Immunopathol Pharmacol 18:255-68. 2005
    ..receptors, P2Y1ATP receptors and several members of the ATP binding cassette (ABC) transporters including MRP1, MRP4 and Pgp. The increase in [Ca2+]i elicited by LTD4 (0...
  45. pmc Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity
    Fang Li
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Drug Metab Dispos 38:2329-38. 2010
    ..4 × 10(-10), R = -0.376). The thiopurine cellular circulation and genetic polymorphisms for genes encoding the proteins involved should be incorporated into future studies of thiopurine drug therapy and effect...
  46. ncbi Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans
    Hanns Ulrich Marschall
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Gastroenterology 129:476-85. 2005
    ..We aimed to study the molecular mechanisms of action of these drugs in humans...
  47. ncbi Change of drug excretory pathway by CCl4-induced liver dysfunction in rat
    Hirotoshi Okumura
    Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Biochem Pharmacol 74:488-95. 2007
    ..such as Ntcp, Oct1, and Oatp2 were decreased and basolateral ATP-binding cassette transporters such as Mrp3 and Mrp4 were increased by the CCl(4) treatment...
  48. ncbi Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport
    Azza A K El-Sheikh
    Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Department of Pharmacology and Toxicology 149, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 320:229-35. 2007
    ..overexpressing the proximal tubular apical efflux transporters human multidrug resistance protein (MRP) 2/ABCC2 and MRP4/ABCC4. MTX was transported by MRP2 and MRP4 with Km values of 480 +/- 90 and 220 +/- 70 microM, respectively...
  49. pmc Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate
    Russell L Legg
    Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA
    Reprod Biol Endocrinol 6:57. 2008
    ..These components each affect androgen-regulated gene expression. The objective of this work was to determine the combined effects of selenium and isoflavones on androgen-regulated gene expression in rat prostate...
  50. doi Down-regulation of Na+/H+ exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4
    Md Tozammel Hoque
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Cancer Res 68:4802-9. 2008
    Multidrug resistance protein 4 (MRP4; ABCC4) is a member of the ATP-binding cassette superfamily of membrane transport proteins and confers resistance to nucleoside and nucleotide analogues as well as camptothecin derivatives...
  51. ncbi Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport
    Susan Pratt
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis IN 46285, USA
    Eur J Pharm Sci 27:524-32. 2006
    ..5 pmol/min/mg prot, while MRP1 (ABCC1) and MRP4 (ABCC4) had little to no uptake...
  52. doi Modulation of bile acid metabolism by 1alpha-hydroxyvitamin D3 administration in mice
    Shigeru Nishida
    Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Drug Metab Dispos 37:2037-44. 2009
    ..These findings indicate that pharmacological activation of VDR enhances metabolism of bile acids, especially urinary excretion. The results confirm that VDR acts a regulator of bile acid metabolism in vivo...
  53. ncbi Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease
    Andrew J Lickteig
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Drug Metab Dispos 35:1970-8. 2007
    ..there were striking increases in both mRNA and protein levels of multidrug resistance-associated protein (Mrp) 3, Mrp4, and breast cancer resistance protein, as well as increased Mrp2 protein...
  54. pmc Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis
    Carol J Soroka
    Yale Liver Center, Yale University School of Medicine, New Haven, CT 06520 8019, USA
    Hepatology 51:181-90. 2010
    ..for the hepatic basolateral membrane export transporters, multidrug resistance-associated protein 3 (Mrp3) and Mrp4, and for the apical bilirubin transporter, Mrp2, were all increased...
  55. pmc Multiple organic anion transporters contribute to net renal excretion of uric acid
    Satish A Eraly
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Physiol Genomics 33:180-92. 2008
    ..Expression of mRNA of other putative urate transporters (UAT, MRP2, MRP4, Oatv1) was unaffected in the knockouts, as were general indexes of renal function (glomerular filtration rate, ..
  56. doi 6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4
    Daniel Janke
    Institute of Pharmacology, University of Mainz, Mainz, Germany
    Hum Mutat 29:659-69. 2008
    Multiple drug resistance protein 4 (MRP4, ABCC4) belongs to the C subfamily of the ATP-binding cassette (ABC) transporter superfamily and participates in the transport of diverse antiviral and chemotherapeutic agents such as 6-..
  57. pmc Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid
    Jonathan M Maher
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 106:319-28. 2008
    ..A single PFDA dose (80 mg/kg) administered to mice increased hepatic Mrp3 (fourfold) and Mrp4 (31-fold) mRNA expression...
  58. ncbi Longitudinal study of a mouse model of familial porphyria cutanea tarda
    D D Arch
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA
    Cell Mol Biol (Noisy-le-grand) 55:46-54. 2009
    ..This murine model of familial PCT affords the opportunity to study changes in porphyrinogen and porphyrin accumulation and transport in the absence of exogenous factors that alter P450 activity and transmembrane transporters...
  59. pmc Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2
    Lauren M Aleksunes
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, CT 06269 3092, USA
    Toxicol Appl Pharmacol 226:74-83. 2008
    ..Similarly, APAP treatment increased hepatic Mrp3 and Mrp4 mRNA and protein in WT, but not Nrf2-null mice...
  60. ncbi ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier
    Holger Bronger
    Division of Tumor Biochemistry, German Cancer Research Center
    Cancer Res 65:11419-28. 2005
    ..Our data provide a basis for the assessment of the role of uptake transporters and efflux pumps in the accessibility of human gliomas for chemotherapeutic agents...
  61. ncbi Effects of angiotensin II receptor blockers on renal handling of uric acid in rats
    Yan Li
    Tokyo University of Science, Faculty of Pharmaceutical Sciences, Japan
    Drug Metab Pharmacokinet 23:263-70. 2008
    ..of uric acid by human URAT1 and others inhibit the transport of uric acid mediated by human URAT1, OAT1, OAT3 and MRP4 in vitro...
  62. pmc Role of MRP4 and MRP5 in biology and chemotherapy
    J Sampath
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    AAPS PharmSci 4:E14. 2002
    ..We first identified, MRP4, based on its ability to efflux antiretroviral compounds, such as azidothymidine monophosphate (AZT-MP) and 9-(2-..
  63. doi Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice
    Edwin C Y Chow
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, M5S 3 M2
    Biopharm Drug Dispos 34:402-16. 2013
    ..and 1,25(OH)2 D3 , 1α(OH)D3 treatment led to higher increases in hepatic Cyp7a1, renal Cyp24a1, VDR, Mdr1 and Mrp4, and intestinal Cyp24a1 and Trpv6 mRNA expression in both fxr(+/+) and fxr(-/-) mice compared to 1,25(OH)2 D3 ..
  64. ncbi Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha
    Jeffrey S Moffit
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Pharmacol Exp Ther 317:537-45. 2006
    ..levels for breast cancer resistance protein (Bcrp) and multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4, respectively)...
  65. ncbi Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells
    Hannah M Prime-Chapman
    Institute for Cell and Molecular Biosciences, University of Newcastle, Medical School, Newcastle upon Tyne NE2 4HH, UK
    J Pharmacol Exp Ther 311:476-84. 2004
    ..In Caco-2 cells, the rank order for mRNA expression was MRP2 > or = MRP6 > MRP4 > or = MRP3 > MRP1 = MRP5...
  66. ncbi cGMP and glutathione-conjugate transport in human erythrocytes
    Antonios Klokouzas
    Department of Pharmacology, University of Cambridge, UK
    Eur J Biochem 270:3696-708. 2003
    ..MRP1, MRP4 and MRP5 are detected in immunoblotting studies with erythrocytes...
  67. ncbi Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats
    Brendan M Johnson
    School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    Drug Metab Dispos 34:556-62. 2006
    ..Mrp2, Mrp3, Mrp4, P-glycoprotein, sodium-dependent taurocholate cotransporting polypeptide, organic anion transporting polypeptides ..
  68. ncbi Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis
    Albert Mennone
    Liver Center and Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    Hepatology 43:1013-21. 2006
    b>Mrp4 is a member of the multidrug resistance-associated gene family that is expressed on the basolateral membrane of hepatocytes and undergoes adaptive upregulation in response to cholestatic injury or bile acid feeding...
  69. pmc Contribution of ABCC4-mediated gastric transport to the absorption and efficacy of dasatinib
    Brian D Furmanski
    Department of Pharmaceutical Sciences, Pathology, and Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Clin Cancer Res 19:4359-70. 2013
    ..oral multikinase inhibitors are known to interact in vitro with the human ATP-binding cassette transporter ABCC4 (MRP4), but the in vivo relevance of this interaction remains poorly understood...
  70. pmc Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma
    Marina Bagnoli
    Fondazione IRCSS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    Biomed Res Int 2013:143202. 2013
    ..Thus, we examined the prognostic role of transporters of the MRP family (i.e., ABCC1/MRP1, ABCC4/MRP4) to gain insights into their clinical impacts...
  71. doi Hypoxia alters ocular drug transporter expression and activity in rat and calf models: implications for drug delivery
    Rajendra S Kadam
    Pharmaceutical Sciences and Ophthalmology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Mol Pharm 10:2350-61. 2013
    ..5-fold in hypoxia. Nine ATP binding cassette (ABC) families of efflux transporters including MRP3, MRP4, MRP5, MRP6, MRP7, Abca17, Abc2, Abc3, and RGD1562128 were up-regulated...
  72. pmc The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge
    Jurgen Schymeinsky
    Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach a d Riss, Germany
    PLoS ONE 8:e61193. 2013
    The multidrug resistance protein 4 (Mrp4) is an ATP-binding cassette transporter that is capable of exporting the second messenger cAMP from cells, a process that might regulate cAMP-mediated anti-inflammatory processes...
  73. pmc Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism
    Youcai Zhang
    Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA
    Biochem Pharmacol 86:437-45. 2013
    ..in BA concentrations in serum or liver, though they had increased mRNA of hepatic BA efflux transporters (Mrp4 and Ostα/β) and ileal BA transporters (Asbt and Ostα/β)...
  74. pmc Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes
    Yassine Sassi
    Institut National de la Santé et de la Recherche Médicale INSERM Université Pierre et Marie Curie, Unite Mixte de Recherche en Sante UMRS 956, Paris, France
    FASEB J 26:1009-17. 2012
    ..This study aimed to determine whether MRP proteins regulate cardiac cAMP homeostasis. Here, we demonstrate that MRP4 is the predominant isoform present at the plasma membrane of cardiacmyocytes and that it mediates the efflux of ..
  75. pmc ABCB1 variation and treatment response in AIDS patients: initial results of the Henan cohort
    Peng Zhu
    Key Laboratory of Molecular Biophysics of Ministry of Education, Huazhong University of Science and Technology, Wuhan, China
    PLoS ONE 8:e55197. 2013
    ..Genotyping of AIDS patients for ABCB1 variation may help predict outcome and potentially could help guide treatment strategies...
  76. pmc Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides
    Chandrima Sinha
    Department of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 288:3786-94. 2013
    ..In this study, we used multidrug resistance protein 4 (MRP4)-expressing cell lines and MRP4 knock-out mice as model systems and wound healing assays as the experimental system ..
  77. doi Single nucleotide polymorphisms in ABCC2 associate with tenofovir-induced kidney tubular dysfunction in Japanese patients with HIV-1 infection: a pharmacogenetic study
    Takeshi Nishijima
    AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan
    Clin Infect Dis 55:1558-67. 2012
    ..The aim of this study was to determine the association between polymorphisms in genes encoding drug transporters and KTD in Japanese patients treated with tenofovir...
  78. doi The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family
    N Skrypek
    INSERM, UMR837, Jean Pierre Aubert Research Center, Lille Cedex, France
    Oncogene 32:1714-23. 2013
    ..Alteration of MRP3, MRP4, hCNT1 and hCNT3 expression was observed in MUC4-KD cells, but only hCNT1 alteration was correlated to MUC4 ..
  79. pmc Efflux protein expression in human stem cell-derived retinal pigment epithelial cells
    Kati Juuti-Uusitalo
    The Institute of Biomedical Technology, University of Tampere, Tampere, Finland
    PLoS ONE 7:e30089. 2012
    ..transporter genes (MRP1, -2, -3, -4, -5, -6, p-gp, and BCRP), the protein expression and localization of MRP1, MRP4, and MRP5, and the functionality of MRP1 efflux pumps at different maturation stages of undifferentiated human ..
  80. doi Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury
    Ramazan Ulu
    Department of Nephrology, Faculty of Medicine, Firat University, Elazig, Turkey
    Food Chem Toxicol 50:1675-9. 2012
    ..cisplatin only treated rats, the induced renal injury increased protein levels of the efflux transporters MRP2 and MRP4 while expression of OAT1, OAT3, OCT1 and OCT2 was reduced...
  81. doi The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related
    Attila Bebes
    Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Hungary
    Arch Dermatol Res 304:57-63. 2012
    ..These results indicate that, besides their possible therapy-modulating effects, xenobiotic transporters may contribute significantly to other keratinocyte functions, such as cell proliferation...
  82. pmc Renal efflux transporter expression in pregnant mice with Type I diabetes
    Lindsay L Yacovino
    Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, 170 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    Toxicol Lett 211:304-11. 2012
    ..Pregnancy decreased the expression of Mdr1b, Mrp4, and 5 proteins and increased the mRNA and protein expression of Mrp3 by 50-60%...
  83. doi Glucoraphanin does not reduce plasma homocysteine in rats with sufficient Se supply via the induction of liver ARE-regulated glutathione biosynthesis enzymes
    Nicole M Blum
    Institute of Agricultural and Nutritional Sciences, Preventive Nutrition Group, Martin Luther University Halle Wittenberg, Von Danckelmann Platz 2, D 06120, Halle Saale, Germany
    Food Funct 2:654-64. 2011
    ..new molecular targets explaining these results, we found a significant down-regulation of the hepatic GSH exporter MRP4 and an up-regulation of the HCys exporter Slco1a4...
  84. doi Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human
    Mark S Warren
    XenoPort, Inc, 3410 Central Expressway, Santa Clara, CA 95051, USA
    Pharmacol Res 59:404-13. 2009
    ..are implicated in xenobiotic exclusion from the brain, including ABCB1 (PGP), ABCG2 (BCRP), ABCC1 (MRP1), ABCC4 (MRP4), and ABCC5 (MRP5)...
  85. doi Unimpaired immune functions in the absence of Mrp4 (Abcc4)
    Rieneke van de Ven
    Department of Pathology, VU University Medical Center Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Immunol Lett 124:81-7. 2009
    ..Recently we reported that the human ATP-binding cassette (ABC) transporter multidrug resistance protein 4 (MRP4 and ABCC4) is required for the migration of human DC...
  86. doi COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells
    Hana Radilova
    GENERI BIOTECH s r o, Hradec Kralove, Czech Republic
    Mol Cell Biochem 330:131-40. 2009
    ..In addition, mRNA expression of multidrug resistance protein 4 (MRP4, ABCC4), supposed to take part in antiviral and anticancer drug transport from cells, was up-regulated after COX-1 ..
  87. doi Efflux protein expression in human retinal pigment epithelium cell lines
    Eliisa Mannermaa
    Department of Pharmaceutics, University of Kuopio, Yliopistonranta 1C, 70210 Kuopio, Finland
    Pharm Res 26:1785-91. 2009
    ..The objective of this study was to characterize efflux proteins (P-glycoprotein (P-gp), multidrug resistance proteins (MRP1-6) and breast cancer resistance protein (BCRP)) of retinal pigment epithelium (RPE) cell lines...
  88. doi Expression of ATP-binding cassette membrane transporters in rodent and human sertoli cells: relevance to the permeability of antiretroviral therapy at the blood-testis barrier
    Kevin R Robillard
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    J Pharmacol Exp Ther 340:96-108. 2012
    ..Expression of multidrug resistance Mdr1a/1b/MDR1/P-gp, Mrp1/MRP1, and Mrp4/MRP4 is confirmed by quantitative polymerase chain reaction and immunoblotting analysis in TM4 cells and HSECs...
  89. pmc Population pharmacokinetic/pharmacogenetic model for optimization of efavirenz therapy in Caucasian HIV-infected patients
    Almudena Sánchez
    Pharmacy Service, University Hospital of Salamanca, Salamanca, Spain
    Antimicrob Agents Chemother 55:5314-24. 2011
    ..The CYP2B6*6 allele, multidrug resistance-associated protein 4 (MRP4) 1497C → T, and gamma-glutamyltranspeptidase (GGT) were identified as major factors influencing the apparent EFV ..
  90. pmc Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells
    Béatrice Marquez
    Unité de Pharmacologie Cellulaire et Moléculaire, Louvain Drug Research Institute, UCL 7370 Avenue Mounier 73, B 1200 Brussels, Belgium
    Antimicrob Agents Chemother 53:2410-6. 2009
    ..Analysis at the mRNA (real-time PCR) and protein (Western blotting) levels revealed an overexpression of Mrp2 and Mrp4. Mrp4 transcripts, however, were overwhelmingly predominant (45% [wild-type cells] to 95% [ciprofloxacin-resistant ..
  91. doi Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism
    Toshiyuki Takahashi
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate 020 8551, Japan
    Biochem Biophys Res Commun 382:549-54. 2009
    ....
  92. pmc Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice
    Maxwell Afari Gyamfi
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Toxicol Appl Pharmacol 234:166-78. 2009
    ..Oatp1a1 and Oatp1b2 mRNA levels were decreased in WT mice fed the MCD diet, whereas the efflux transporter Mrp4 was increased...
  93. doi ABC efflux transporters in brain vasculature of Alzheimer's subjects
    Hasini C Wijesuriya
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK
    Brain Res 1358:228-38. 2010
    ..of the ATP-Binding cassette (ABC) family, P-glycoprotein (Pgp), multidrug-resistance associated protein 4 (MRP4) and breast cancer resistance protein (BCRP), located on endothelial cells lining brain vasculature play important ..
  94. ncbi Sequence of a novel mRNA coding for a C-terminal-truncated form of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase
    F Pichaud
    U 349 INSERM, Hopital Lariboisiere, Paris, France
    Gene 162:319-22. 1995
    ..Hybridization studies using specific probes indicated that this new mRNA form probably corresponded to the 3.4-kb mRNA, one of the two 15-PGDH mRNAs previously detected in Northern blot analysis...
  95. pmc Role of breast cancer resistance protein in the adaptive response to cholestasis
    Albert Mennone
    Department of Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8019, USA
    Drug Metab Dispos 38:1673-8. 2010
    ..Ost) α and multidrug resistance protein 1 and kidney multidrug resistance-associated protein (Mrp) 2, Mrp3, and Mrp4 were significantly greater in the sham Bcrp KO versus sham WT mice...
  96. doi Expression of ABC-type transport proteins in human platelets
    Juliane Niessen
    Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University, Greifswald, Germany
    Pharmacogenet Genomics 20:396-400. 2010
    ..Their functions may be related to glutathione and lipid homeostasis, secretion of lipid mediators, cell protection as well as drug transport...
  97. doi Vectorial transport of nucleoside analogs from the apical to the basolateral membrane in double-transfected cells expressing the human concentrative nucleoside transporter hCNT3 and the export pump ABCC4
    Maria Rius
    Division of Tumor Biochemistry, German Cancer Research Center, D 69120 Heidelberg, Germany
    Drug Metab Dispos 38:1054-63. 2010
    ..The results contribute to a better understanding of the cellular transport characteristics of nucleoside drugs...
  98. doi The impact of resuscitated fecal peritonitis on the expression of the hepatic bile salt transporters in a porcine model
    Joost Wauters
    Medical Intensive Care Unit, University Hospitals of the Katholieke Universiteit Leuven, Leuven, Belgium
    Shock 34:508-16. 2010
    ..001), respectively, in comparison with controls, whereas multidrug resistance-associated protein 4 (MRP4) mRNA was upregulated by 85% (P = 0.02). Bile salt export pump and MRP2 staining were downregulated in septic pigs...
  99. ncbi ABC multidrug transporters: target for modulation of drug pharmacokinetics and drug-drug interactions
    Béatrice Marquez
    Pharmacologie Cellulaire et Moléculaire, Louvain Drug Research Institute, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Curr Drug Targets 12:600-20. 2011
    ..cells, they expel drugs back to the external medium (if located at the apical side [P-glycoprotein, BCRP, MRP2, MRP4 in the kidney]) or to the blood (if located at the basolateral side [MRP1, MRP3, MRP4, MRP5]), modulating thereby ..
  100. doi Constitutive mRNA expression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss)
    Stephan Fischer
    Department of Bioanalytical Ecotoxicology, UFZ Helmholtz Centre for Environmental Research, 04318 Leipzig, Germany
    Aquat Toxicol 101:438-46. 2011
    ..Our data indicate that transporter expression and activity patterns in the different trout cell lines are irrespective of the tissue of origin, but are determined by factors of cell cultivation...

Research Grants71

  1. Growth factors and engineered stroma for HSC expansion
    Harvey Lodish; Fiscal Year: 2006
    ..protein T16; Cytokine Receptor-like Factor, and three members of the Proliferin gene family, Proliferin- 1; Mrp4, and proliferin- related protein (PRP)...
  2. Function of the MRP Family
    GARY KRUH; Fiscal Year: 2006
    ..and others have determined that the first three of the newly identified family members to be examined, MRP3, MRP4 and MRP5, are also drug pumps involved in cellular resistance to anticancer agents...
  3. HIV RESISTANCE AND TREATMENT STRATEGIES
    RICHARD D AQUILA; Fiscal Year: 2007
    ..and/or MRP2 (ABCC2)), nucleoside influx (OAT1, OAT3, and OAT4, CNT-1 and-2, and ENTs), and nucleoside efflux (MRP4 (ABCC4), MRP5 (ABCC5) are expressed and functional in lymphocytes...
  4. Inhibition of an apical cAMP transporter (MRP4) in the gut induces diarrhea
    Anjaparavanda Naren; Fiscal Year: 2009
    The hypothesis of this proposal is that the functional activities of the cAMP transporter (MRP4) and CFTR Cl- channel are physically and functionally coupled within the gut epithelial cells...
  5. Inhibition of an apical cAMP transporter (MRP4) in the gut induces diarrhea
    Anjaparavanda P Naren; Fiscal Year: 2010
    The hypothesis of this proposal is that the functional activities of the cAMP transporter (MRP4) and CFTR Cl- channel are physically and functionally coupled within the gut epithelial cells...
  6. Molecular Organization or Renal Organic Anion Transport
    Stephen Wright; Fiscal Year: 2007
    ..e., OAT1 and OAT3) and two distinct luminal transporters (i.e., MRP2 and MRP4)...
  7. Molecular Organization or Renal Organic Anion Transport
    Stephen H Wright; Fiscal Year: 2010
    ..e., OAT1 and OAT3) and two distinct luminal transporters (i.e., MRP2 and MRP4)...
  8. Molecular Organization or Renal Organic Anion Transport
    Stephen Wright; Fiscal Year: 2009
    ..e., OAT1 and OAT3) and two distinct luminal transporters (i.e., MRP2 and MRP4)...
  9. ILEAL BILE ACID TRANSPORTER METABOLISM AND REGULATION
    Paul A Dawson; Fiscal Year: 2010
    ..findings, the studies in Specific Aim 1 are designed to test the hypothesis that the ABC transporters Mrp3 and Mrp4 are responsible for the residual bile acid transport and serve to protect the ileal epithelium from bile acid-..
  10. MRP4 IN DRUG SENSITIVITY AND PHYSIOLOGY
    John Schuetz; Fiscal Year: 2009
    ..the last funding period were directed to elucidating the function and molecular regulation of the ABC transporter, Mrp4. The current proposal represents an evolution of this work, based upon recent studies from this laboratory using ..
  11. MRP4 IN DRUG SENSITIVITY AND PHYSIOLOGY
    John D Schuetz; Fiscal Year: 2010
    ..the last funding period were directed to elucidating the function and molecular regulation of the ABC transporter, Mrp4. The current proposal represents an evolution of this work, based upon recent studies from this laboratory using ..
  12. Role of Multidrug Resistance Proteins 2 and/or 4, and DMPS and DMSA in the Renal
    CHRISTY BRIDGES; Fiscal Year: 2007
    ..not express the Mrp2 protein, and Madin-Darby canine kidney (MDCK) cells stably transfected with OAT1 and MRP2 or MRP4. We will first examine the effect of DMPS and DMSA on the handling and disposition of CH3Hg+ and Hg2+ in control ..
  13. Function of the MRP Family
    GARY KRUH; Fiscal Year: 2006
    ..and others have determined that the first three of the newly identified family members to be examined, MRP3, MRP4 and MRP5, are also drug pumps involved in cellular resistance to anticancer agents...
  14. ABC Transporters in CNS Penetration of Camptothecins
    Christopher Waters; Fiscal Year: 2007
    ..and the CSF is largely controlled by drug efflux transporters, including P-pg, multi-drug resistance protein 4 (MRP4), and the breast cancer resistance protein (BCRP or ABCG2)...
  15. The Hepatoprotective Role of the Orphan Nuclear Receptor LXR
    Wen Xie; Fiscal Year: 2009
    ..The APAP-detoxifying transporter MRP4 is also likely under the positive control of LXR...
  16. The Hepatoprotective Role of the Orphan Nuclear Receptor LXR
    Wen Xie; Fiscal Year: 2010
    ..The APAP-detoxifying transporter MRP4 is also likely under the positive control of LXR...
  17. MRP4 IN DRUG SENSITIVITY AND PHYSIOLOGY
    John Schuetz; Fiscal Year: 2007
    ..This was the case for the ABC transporter Mrp4 that was an orphan ABC transporter until our studies first determined that it was unique in its ability to ..
  18. MECHANISMS OF BILE SECRETION AND CHOLESTASIS
    James Boyer; Fiscal Year: 2007
    ..will be sought as well as the effects of cholestasis on the expression of organic cation transporters (Octs) and Mrp4 in liver, kidney and intestine and the ameliorating effects of ursodeoxycholic acid...
  19. Astrocyte Control of Toxin-Mediated Neuron Death: Role of the Gamma-Glutamyl Path
    George I Henderson; Fiscal Year: 2010
    ..They will utilize transgenic mice deficient in Mrpl, Mrp4, or GGT...
  20. Transporter Expression in Response to Hepatotoxicants
    Jose E Manautou; Fiscal Year: 2010
    ..During the current funding cycle we determined that the efflux transporter Mrp4 is the most significantly induced MRP during APAP hepatotoxicity...
  21. Astrocyte Control of Toxin-Mediated Neuron Death: Role of the Gamma-Glutamyl Path
    George Henderson; Fiscal Year: 2007
    ..They will utilize transgenic mice deficient in Mrpl, Mrp4, or GGT...
  22. Role of MRP2 and MRP4 in renal organic anion excretion
    RYAN PELIS; Fiscal Year: 2007
    ..make use of cloned proteins isolated in model cell systems, and are designed to test the hypothesis that MRP2 and MRP4, both of which are localized to the apical membrane of RPT cells, contribute to the secretion of OAs primarily ..