MRC1

Summary

Gene Symbol: MRC1
Description: mannose receptor C-type 1
Alias: CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1, hMR, macrophage mannose receptor 1, C-type lectin domain family 13 member D, human mannose receptor, macrophage mannose receptor 1-like protein 1, mannose receptor, C type 1-like 1
Species: human
Products:     MRC1

Top Publications

  1. Taylor M, Bezouska K, Drickamer K. Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. J Biol Chem. 1992;267:1719-26 pubmed
    ..In the mannose receptor, these multiple weak interactions are achieved through several active CRDs in a single polypeptide chain rather than by oligomerization of polypeptides each containing a single CRD. ..
  2. Lennartz M, Cole F, Shepherd V, Wileman T, Stahl P. Isolation and characterization of a mannose-specific endocytosis receptor from human placenta. J Biol Chem. 1987;262:9942-4 pubmed
    ..Polyclonal antibodies generated against the mannose binding protein immunoprecipitate a single 175-kDa protein species from both surface-iodinated and biosynthetically labeled human monocyte-derived macrophages. ..
  3. Chieppa M, Bianchi G, Doni A, Del Prete A, Sironi M, Laskarin G, et al. Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program. J Immunol. 2003;171:4552-60 pubmed
  4. Trujillo J, Rogers R, Molina R, Dangond F, McLane M, Essex M, et al. Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor. Proc Natl Acad Sci U S A. 2007;104:5097-102 pubmed
    ..Therefore, characterization of the HIV-1 noninfectious MR-mediated phagocytic pathway may foster advances in HIV-1 vaccine design and an improved understanding of HIV-1/AIDS pathogenesis and host defenses. ..
  5. Hattori T, Konno S, Takahashi A, Isada A, Shimizu K, Shimizu K, et al. Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis. BMC Med Genet. 2010;11:151 pubmed publisher
    ..The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with sarcoidosis...
  6. Ezekowitz R, Sastry K, Bailly P, Warner A. Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. J Exp Med. 1990;172:1785-94 pubmed
    ..Deletion of the cytoplasmic tail results in a mutant receptor that is able to bind but not ingest the ligated pathogens, suggesting that the signal for phagocytosis is contained in the cytoplasmic tail. ..
  7. Taylor M, Conary J, Lennartz M, Stahl P, Drickamer K. Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains. J Biol Chem. 1990;265:12156-62 pubmed
    ..This structure suggests that the receptor may contain multiple ligand-binding domains thus accounting for its tight binding to highly multivalent ligands. ..
  8. Eichbaum Q, Clerc P, Bruns G, McKeon F, Ezekowitz R. Assignment of the human macrophage mannose receptor gene (MRC1) to 10p13 by in situ hybridization and PCR-based somatic cell hybrid mapping. Genomics. 1994;22:656-8 pubmed
  9. Liu Y, Liu H, Kim B, Gattone V, Li J, Nath A, et al. CD4-independent infection of astrocytes by human immunodeficiency virus type 1: requirement for the human mannose receptor. J Virol. 2004;78:4120-33 pubmed
    ..In the present study using an expression cloning strategy, the cDNA for the human mannose receptor (hMR) was found to be essential for CD4-independent HIV-1 infectivity...

More Information

Publications106 found, 100 shown here

  1. Zhang J, Zhu J, Imrich A, Cushion M, Kinane T, Koziel H. Pneumocystis activates human alveolar macrophage NF-kappaB signaling through mannose receptors. Infect Immun. 2004;72:3147-60 pubmed
  2. Kang P, Azad A, Torrelles J, Kaufman T, Beharka A, Tibesar E, et al. The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J Exp Med. 2005;202:987-99 pubmed
    ..0 +/- 5.1% vs. 38.6 +/- 0.6%). Thus, engagement of the MR by ManLAM during the phagocytic process directs M.tb to its initial phagosomal niche, thereby enhancing survival in human macrophages. ..
  3. Royer P, Emara M, Yang C, Al Ghouleh A, Tighe P, Jones N, et al. The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity. J Immunol. 2010;185:1522-31 pubmed publisher
    ..In conclusion, our work demonstrates a major role for MR in glycoallergen recognition and in the development of Th2 responses...
  4. Fanibunda S, Modi D, Gokral J, Bandivdekar A. HIV gp120 binds to mannose receptor on vaginal epithelial cells and induces production of matrix metalloproteinases. PLoS ONE. 2011;6:e28014 pubmed publisher
    ..We have previously reported human mannose receptor (hMR) as a CD4 independent receptor playing a role in HIV transmission on human spermatozoa...
  5. Le Cabec V, Emorine L, Toesca I, Cougoule C, Maridonneau Parini I. The human macrophage mannose receptor is not a professional phagocytic receptor. J Leukoc Biol. 2005;77:934-43 pubmed
    ..When we searched to clone de novo the human MR (hMR) cDNA, problems were encountered, and full-length hMR cDNA was only obtained after devising a complex cloning ..
  6. López Herrera A, Liu Y, Rugeles M, He J. HIV-1 interaction with human mannose receptor (hMR) induces production of matrix metalloproteinase 2 (MMP-2) through hMR-mediated intracellular signaling in astrocytes. Biochim Biophys Acta. 2005;1741:55-64 pubmed
    Astrocytes are susceptible to HIV-1 infection. We have recently demonstrated that human mannose receptor (hMR) is directly involved in CD4-independent HIV-1 infection of astrocytes...
  7. Zhang J, Tachado S, Patel N, Zhu J, Imrich A, Manfruelli P, et al. Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro. J Leukoc Biol. 2005;78:665-74 pubmed
    ..Taken together, these data suggest that mannose receptors on human AM may suppress select proinflammatory cytokine release and may serve to regulate the innate inflammatory responses to infectious challenge in the lungs. ..
  8. Lai J, Bernhard O, Turville S, Harman A, Wilkinson J, Cunningham A. Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1. J Biol Chem. 2009;284:11027-38 pubmed publisher
  9. Kim J, Hematti P. Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages. Exp Hematol. 2009;37:1445-53 pubmed publisher
    ..Macrophages cocultured with MSCs consistently showed high-level expression of CD206, a marker of alternatively activated macrophages...
  10. Wang D, Feng J, Li Y, Zhang D, Li X, Li Q, et al. Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China. Hum Genet. 2012;131:1251-60 pubmed publisher
    ..In the present study, we genotyped 12 genetic variants of the MRC1 gene and the IFNG gene in 527 Han Chinese with leprosy and 583 healthy individuals from Yunnan, China, to discern ..
  11. Vigerust D, Egan B, Shepherd V. HIV-1 Nef mediates post-translational down-regulation and redistribution of the mannose receptor. J Leukoc Biol. 2005;77:522-34 pubmed
    ..These data suggest that the MR is a potential intracellular target of Nef and that this regulation may represent a mechanism to further cripple the host innate immune system. ..
  12. Tachado S, Zhang J, Zhu J, Patel N, Cushion M, Koziel H. Pneumocystis-mediated IL-8 release by macrophages requires coexpression of mannose receptors and TLR2. J Leukoc Biol. 2007;81:205-11 pubmed
  13. Op den Brouw M, Binda R, Geijtenbeek T, Janssen H, Woltman A. The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells. Virology. 2009;393:84-90 pubmed publisher
    ..These data suggest that in HBV infected patients, MR-mediated interaction between HBsAg and DC and subsequent impairment of DC predominantly occurs at the main site of infection, the liver...
  14. Hattori T, Konno S, Hizawa N, Isada A, Takahashi A, Shimizu K, et al. Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations. Immunogenetics. 2009;61:731-8 pubmed publisher
    ..The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with asthma in two independent populations...
  15. Alter A, de Léséleuc L, Van Thuc N, Thai V, Huong N, Ba N, et al. Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. Hum Genet. 2010;127:337-48 pubmed publisher
    ..The MRC1 gene, encoding the human mannose receptor (MR), is located in the 10p13 region and non-synonymous SNPs in exon 7 of the gene have been suggested as ..
  16. Zhu Y, Li X, Chen J, Chen T, Shi Z, Lei M, et al. The pentacyclic triterpene Lupeol switches M1 macrophages to M2 and ameliorates experimental inflammatory bowel disease. Int Immunopharmacol. 2016;30:74-84 pubmed publisher
    ..This was associated with a down-regulation of CD86, a typical marker of M1 macrophages, and an up-regulation of CD206, a typical M2 macrophage marker...
  17. Kurniati A, Chen C, Efendi F, Berliana S. Factors Influencing Indonesian Women's Use of Maternal Health Care Services. Health Care Women Int. 2017;: pubmed publisher
    ..By the end of Millennium Development Goals (MDGs) the maternal mortality ratio (MMR) has been successfully reduced by almost half since 1990 (United Nations, 2015)...
  18. Hong K, Yu Z, Sun X, Wu C, Weng P, Wei M, et al. [Effect of caveolin-1 scaffolding domain peptides on heme oxygenase-1 activity increasing and M1/M2 phenotype polarization in rat alveolar macrophages induced by lipopolysaccharide]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018;30:855-860 pubmed publisher
    ..tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), leukocyte differentiation antigen 206 (CD206) and IL-10 were determined by real-time fluorescent quantitative reverse transcription-polymerase chain reaction (..
  19. Croce E, Hatz C, Jonker E, Visser L, Jaeger V, Bühler S. Safety of live vaccinations on immunosuppressive therapy in patients with immune-mediated inflammatory diseases, solid organ transplantation or after bone-marrow transplantation - A systematic review of randomized trials, observational studies and ca. Vaccine. 2017;35:1216-1226 pubmed publisher
    ..Live vaccinations: mumps, measles, rubella (MMR), yellow fever (YF), varicella vaccine (VV), herpes zoster (HZ), oral typhoid, oral polio, rotavirus, Bacillus ..
  20. Yin K, You Y, Swier V, Tang L, Radwan M, Pandya A, et al. Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine. Arterioscler Thromb Vasc Biol. 2015;35:2432-42 pubmed publisher
    ..Cytochrome P450 (CYP)27B1 and VD receptor were predominantly present in the CD206(+) M2 macrophage foam cell-accumulated cores in coronary artery plaques...
  21. Miller E, Moro P, Cano M, Shimabukuro T. Deaths following vaccination: What does the evidence show?. Vaccine. 2015;33:3288-92 pubmed publisher
    ..multi-state measles outbreak of 2014-2015, unsubstantiated claims of deaths caused by measles, mumps, and rubella (MMR) vaccine began circulating on the Internet, prompting responses by public health officials to address common ..
  22. Ndisang J, Mishra M. The heme oxygenase system selectively suppresses the proinflammatory macrophage m1 phenotype and potentiates insulin signaling in spontaneously hypertensive rats. Am J Hypertens. 2013;26:1123-31 pubmed publisher
    ..protein 1 alpha (MIP-1α) while enhancing anti-inflammatory macrophage M2 phenotype by potentiating ED2, CD206, and CD14...
  23. Kandasamy R, Voysey M, McQuaid F, de Nie K, Ryan R, Orr O, et al. Non-specific immunological effects of selected routine childhood immunisations: systematic review. BMJ. 2016;355:i5225 pubmed publisher
    ..on the possible non-specific or heterologous immunological effects of BCG; measles; mumps, measles, and rubella (MMR); diphtheria; tetanus; and pertussis vaccines...
  24. Liu H, Garzoni L, Herry C, Durosier L, Cao M, Burns P, et al. Can Monitoring Fetal Intestinal Inflammation Using Heart Rate Variability Analysis Signal Incipient Necrotizing Enterocolitis of the Neonate?. Pediatr Crit Care Med. 2016;17:e165-76 pubmed publisher
    ..Upon necropsy, ionized calcium binding adaptor molecule 1+ (Iba1+), CD11c+ (M1), CD206+ (M2 macrophages), and occludin (leakiness marker) immunofluorescence in the terminal ileum was quantified along ..
  25. Du Plessis J, van Pelt J, Korf H, Mathieu C, Van Der Schueren B, Lannoo M, et al. Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease. Gastroenterology. 2015;149:635-48.e14 pubmed publisher
    ..Flow cytometry showed increased proportions of CD11c+CD206+ and CCR2+ macrophages in VAT from patients with NASH, and supernatants of cultured macrophages had increased ..
  26. Hill H, Elam Evans L, Yankey D, Singleton J, Kang Y. Vaccination Coverage Among Children Aged 19-35 Months - United States, 2016. MMWR Morb Mortal Wkly Rep. 2017;66:1171-1177 pubmed publisher
    ..Coverage remained ?90% for ?3 doses of poliovirus vaccine (91.9%), ?1 dose of measles, mumps, and rubella vaccine (MMR) (91.1%), ?1 dose of varicella vaccine (90.6%), and ?3 doses of hepatitis B vaccine (HepB) (90.5%)...
  27. Crişan A, BădeliŢă S, Jardan C, Vasilache E, Dobrea C, Gheorghe A, et al. The occurrence of chronic lymphocytic leukemia after chronic phase of chronic myeloid leukemia: case report and literature review. Rom J Morphol Embryol. 2015;56:1145-51 pubmed
    ..At that time, the patient was in complete cytogenetic response (CCyR) and major molecular response (MMR) of CML clone according to European LeukemiaNet (ELN) recommendations and presented clinical and hematological ..
  28. Gilley P, Uhler K, Watson K, Yoshinaga Itano C. Spectral-temporal EEG dynamics of speech discrimination processing in infants during sleep. BMC Neurosci. 2017;18:34 pubmed publisher
    ..These insights into the neurophysiological mechanisms of auditory discrimination provide a basis for exploring the clinically utility of the MMR TF and other auditory oddball responses.
  29. Wang C, Zhao C, Zhang X, Xu L, Jia X, Sun H, et al. The polymorphisms of MSH6 gene are associated with AIDS progression in a northern Chinese population. Infect Genet Evol. 2016;42:9-13 pubmed publisher
    ..One DNA repair pathway, the mismatch repair (MMR) is associated with a wide variety of tumors...
  30. Velazquez K, Enos R, Carson M, Cranford T, Bader J, Chatzistamou I, et al. Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model. Am J Physiol Gastrointest Liver Physiol. 2016;311:G699-G712 pubmed publisher
    ..changes that resemble dysplastic alterations in the liver and presented a higher percentage of F4/80+CD206+ macrophages and activated T cells (CD4+CD69+) in the spleen and lymph nodes, ..
  31. Rajaram M, Arnett E, Azad A, Guirado E, Ni B, Gerberick A, et al. M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcR?-Chain, Grb2, and SHP-1. Cell Rep. 2017;21:126-140 pubmed publisher
    Despite its prominent role as a C-type lectin (CTL) pattern recognition receptor, mannose receptor (MR, CD206)-specific signaling molecules and pathways are unknown...
  32. Ma S, Xiong Y, Jiang L, Chen Q. Risk of febrile seizure after measles-mumps-rubella-varicella vaccine: A systematic review and meta-analysis. Vaccine. 2015;33:3636-49 pubmed publisher
    ..a clear preference for use of measles-mumps-rubella-varicella (MMRV) vaccine over separate measles-mumps-rubella (MMR) and varicella (V) vaccine...
  33. Alemayehu M, Kalayu A, Desta A, Gebremichael H, Hagos T, Yebyo H. Rural women are more likely to use long acting contraceptive in Tigray region, Northern Ethiopia: a comparative community-based cross sectional study. BMC Womens Health. 2015;15:71 pubmed publisher
    In the latest report of Ethiopian Demographic and Health Survey (EDHS) 2011, the maternal mortality ratio (MMR) was estimated at 676/100,000 live births, with total fertility rate at 4.8 and contraceptive prevalence rate at 29 %...
  34. Iro M, Sadarangani M, Goldacre R, Nickless A, Pollard A, Goldacre M. 30-year trends in admission rates for encephalitis in children in England and effect of improved diagnostics and measles-mumps-rubella vaccination: a population-based observational study. Lancet Infect Dis. 2017;17:422-430 pubmed publisher
    ..rate trends for specified aetiologies in relation to introduction of PCR testing and measles-mumps-rubella (MMR) vaccination...
  35. Li Q, Feng Y, He W, Wang L, Wang R, Dong L, et al. Post-screening characterisation and in vivo evaluation of an anti-inflammatory polysaccharide fraction from Eucommia ulmoides. Carbohydr Polym. 2017;169:304-314 pubmed publisher
    ..Among them, EUP1 was the only fraction to exert such a function - it stimulated Raw 264.7 cells to express CD206 and a key anti-inflammatory cytokine interleukin-10...
  36. Han N, Kim M, Lee H, Kim W. Loss of ARID1A Expression is Related to Gastric Cancer Progression, Epstein-Barr Virus Infection, and Mismatch Repair Deficiency. Appl Immunohistochem Mol Morphol. 2016;24:320-5 pubmed publisher
    ..in gastric cancer (GC), and examined its association with Epstein-Barr virus-associated (EBV) GC, mismatch repair (MMR) deficiency, and p53 alteration...
  37. André T, de Gramont A, Vernerey D, Chibaudel B, Bonnetain F, Tijeras Raballand A, et al. Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study. J Clin Oncol. 2015;33:4176-87 pubmed publisher
    ..This update presents 10-year OS and OS and DFS by mismatch repair (MMR) status and BRAF mutation...
  38. Haraldsdottir S, Roth R, Pearlman R, Hampel H, Arnold C, Frankel W. Mismatch repair deficiency concordance between primary colorectal cancer and corresponding metastasis. Fam Cancer. 2016;15:253-60 pubmed publisher
    ..The mismatch repair (MMR) immunohistochemistry (IHC) concordance rate between primary colorectal cancer (CRC) and metastasis is unknown...
  39. Sugano K, Nakajima T, Sekine S, Taniguchi H, Saito S, Takahashi M, et al. Germline PMS2 mutation screened by mismatch repair protein immunohistochemistry of colorectal cancer in Japan. Cancer Sci. 2016;107:1677-1686 pubmed publisher
    ..No mutations were identified in the other MMR genes (i.e. MSH2, MLH1 and MSH6). The prevalence of the downregulated expression of the PMS2 protein alone was 1...
  40. Ma Y, Chen Y, Petersen I. Expression and promoter DNA methylation of MLH1 in colorectal cancer and lung cancer. Pathol Res Pract. 2017;213:333-338 pubmed publisher
    ..The aims of this study were to analyze the methylation status of MLH1, one of the DNA mismatch repair (MMR) genes, in human colorectal and lung cancer and to evaluate its clinical relevance...
  41. Jiao H, Natoli R, Valter K, Provis J, Rutar M. Spatiotemporal Cadence of Macrophage Polarisation in a Model of Light-Induced Retinal Degeneration. PLoS ONE. 2015;10:e0143952 pubmed publisher
    ..Expression of M1- (Ccl3, Il-6, Il-12, Il-1β, TNFα) and M2- (CD206, Arg1, Igf1, Lyve1, Clec7a) related markers followed discrete profiles following light damage; up-regulation of M1 ..
  42. Gras Le Guen C, Legrand A, Caquard M, Micaelli X, Picherot G, Lacroix S, et al. Chronically ill adolescents are also incompletely vaccinated: A cross-sectional study in France. Vaccine. 2017;35:4707-4712 pubmed publisher
    ..vaccines: diphtheria, tetanus, acellular pertussis, inactivated poliovirus (DTaP/IPV), measles-mumps-rubella (MMR), hepatitis B (HepB), meningococcal C conjugate (MnC), human papillomavirus (HPV) and composite combinations (e.g...
  43. Barreto I, Andrade S, Cunha F, Lima M, Araujo M, Almeida L. A robotic magnetic nanoparticle solid phase extraction system coupled to flow-batch analyzer and GFAAS for determination of trace cadmium in edible oils without external pretreatment. Talanta. 2018;178:384-391 pubmed publisher
    A lab-made magnetic-mechanical robotic (MMR) system coupled to a flow-batch analyzer (FBA) for magnetic nanoparticles solid phase extraction (MSPE) is presented...
  44. SenGupta T, Torgersen M, Kassahun H, Vellai T, Simonsen A, Nilsen H. Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy. Nat Commun. 2013;4:2674 pubmed publisher
    Cellular responses to DNA damage involve distinct DNA repair pathways, such as mismatch repair (MMR) and base excision repair (BER)...
  45. Buecher B, de Pauw A, Bazire L, Houdayer C, Fievet A, Moncoutier V, et al. Sporadic endometrial adenocarcinoma with MMR deficiency due to biallelic MSH2 somatic mutations. Fam Cancer. 2018;17:281-285 pubmed publisher
    The invalidation of the Mismatch Repair (MMR) system is responsible for a so-called "deficient MMR" phenotype (dMMR) characterized by microsatellite instability and abnormal pattern of expression of MMR proteins in tumor tissue...
  46. Rao Z, Sun J, Pan X, Chen Z, Sun H, Zhang P, et al. Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver-Resident Macrophage M2 Polarization via C/EBP Homologous Protein-Mediated Endoplasmic Reticulum Stress. Front Immunol. 2017;8:1299 pubmed publisher
    ..inhibited IL-10-secreting M2-like macrophage polarization, as revealed by decreased Arg1 and Mrc1 gene induction accompanied by a decrease in STAT3 and STAT6 signaling pathway activation...
  47. Bavdekar A, Oswal J, Ramanan P, Aundhkar C, Venugopal P, Kapse D, et al. Immunogenicity and safety of measles-mumps-rubella vaccine delivered by disposable-syringe jet injector in India: A randomized, parallel group, non-inferiority trial. Vaccine. 2018;36:1220-1226 pubmed publisher
    We conducted a randomized, non-inferiority, clinical study of MMR vaccine by a disposable-syringe jet injector (DSJI) in toddlers in India in comparison with the conventional administration...
  48. Li X, Zhang Y, Li X, Zheng H, Peng J, Fu S. Sustained exercise-trained juvenile black carp (Mylopharyngodon piceus) at a moderate water velocity exhibit improved aerobic swimming performance and increased postprandial metabolic responses. Biol Open. 2018;7: pubmed publisher
    ..showed significantly higher critical swimming speed (Ucrit) and maximum metabolic rate (MMR) over the control group...
  49. Jia J, Wang Z, Cai J, Zhang Y. PMS2 expression in epithelial ovarian cancer is posttranslationally regulated by Akt and essential for platinum-induced apoptosis. Tumour Biol. 2016;37:3059-69 pubmed publisher
    ..The sensitivity of tumor cells to cisplatin is frequently affected by defect in DNA mismatch repair (MMR), which repairs mispaired DNA sequences and regulates DNA-damage-induced apoptosis...
  50. Chung E, Lee G, Lee C, Ye M, Chung H, Kim H, et al. Bee Venom Phospholipase A2, a Novel Foxp3+ Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating Neuroinflammatory Responses in a Mouse Model of Parkinson's Disease. J Immunol. 2015;195:4853-60 pubmed publisher
    ..Furthermore, our results showed that bvPLA2 directly bound to CD206 on dendritic cells and consequently promoted the secretion of PGE2, which resulted in Treg differentiation via ..
  51. Jeong S, Kim J, Lee C, Park Y, Kim S, Yoon S, et al. Tumor associated macrophages provide the survival resistance of tumor cells to hypoxic microenvironmental condition through IL-6 receptor-mediated signals. Immunobiology. 2017;222:55-65 pubmed publisher
    ..In this study, the established mouse tumor tissues showed a dense infiltration of CD206+ macrophages at the junctions between the normoxic and hypoxic regions and an increased IL-6 receptor (..
  52. Guo C, Chen Y, Gao W, Chang A, Ye Y, Shen W, et al. Liposomal Nanoparticles Carrying anti-IL6R Antibody to the Tumour Microenvironment Inhibit Metastasis in Two Molecular Subtypes of Breast Cancer Mouse Models. Theranostics. 2017;7:775-788 pubmed publisher
    ..and moderated the TME, characterized by the reduced expression of genes encoding Stat3, Sox2, VEGFA, MMP-9 and CD206 in the breast tissues...
  53. Rudolph C, Melau C, Nielsen J, Vile Jensen K, Liu D, Pena Diaz J, et al. Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours. Cell Oncol (Dordr). 2017;40:341-355 pubmed publisher
    ..The aim of this study was to investigate the role of the DNA mismatch repair (MMR) system in the cisplatin sensitivity of TGCT...
  54. Miyamoto T, Ando H, Asaka R, Yamada Y, Shiozawa T. Mutation analysis by whole exome sequencing of endometrial hyperplasia and carcinoma in one patient: Abnormalities of polymerase epsilon and the phosphatidylinositol-3 kinase pathway. J Obstet Gynaecol Res. 2017;: pubmed publisher
    ..These common mutations included polymerase epsilon (POLE) and DNA mismatch repair (MMR) genes, indicating that an ultra-mutated phenotype, and also included PTEN and PIK3CA...
  55. Tomasek J, Kiss I. [Immunotherapy of Colorectal and Anal Carcinoma]. Klin Onkol. 2017;30:62-65 pubmed publisher
    ..The breakthrough has become the recognition of the mismatch repair system (MMR) that affects the microsatellite instability (MSI) and its role in the development of colorectal carcinoma (CRC)...
  56. Ashour M. Changes in out-of-pocket payments and health-seeking behaviours in the Gaza Strip. Lancet. 2018;391 Suppl 2:S25 pubmed publisher
    ..Mixed methods research (MMR) was used...
  57. de la Morena M. Clinical Phenotypes of Hyper-IgM Syndromes. J Allergy Clin Immunol Pract. 2016;4:1023-1036 pubmed publisher
    ..CSR utilizes elements of the DNA repair machinery including multi-protein complexes involved in mismatch repair (MMR)...
  58. Arciuolo R, Jablonski R, Zucker J, Rosen J. Effectiveness of Measles Vaccination and Immune Globulin Post-Exposure Prophylaxis in an Outbreak Setting-New York City, 2013. Clin Infect Dis. 2017;65:1843-1847 pubmed publisher
    Measles, mumps, and rubella vaccine (MMR) or immune globulin (IG) are routinely used for measles post-exposure prophylaxis (PEP). However, current literature on the effectiveness of measles PEP is limited and variable...
  59. Stewart C, Bigby S, Giardina T, Grieu Iacopetta F, Amanuel B. An immunohistochemical and molecular analysis of papillary proliferation of the endometrium. Pathology. 2018;50:286-292 pubmed publisher
    ..CPHs) were examined immunohistochemically for expression of PAX2, BAF250a, p16, ?-catenin and DNA mismatch repair (MMR) proteins. Molecular analysis was also performed on the CPHs using targeted next generation sequencing (NGS)...
  60. DesJardin L, Kaufman T, Potts B, Kutzbach B, Yi H, Schlesinger L. Mycobacterium tuberculosis-infected human macrophages exhibit enhanced cellular adhesion with increased expression of LFA-1 and ICAM-1 and reduced expression and/or function of complement receptors, FcgammaRII and the mannose receptor. Microbiology. 2002;148:3161-71 pubmed
  61. Azad A, Rajaram M, Metz W, Cope F, Blue M, Vera D, et al. γ-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206). J Immunol. 2015;195:2019-29 pubmed publisher
    ..microenvironment, human macrophages were used that have high expression of the C-type lectin mannose receptor (MR; CD206)...
  62. Guedes L, Antonarakis E, Schweizer M, Mirkheshti N, Almutairi F, Park J, et al. MSH2 Loss in Primary Prostate Cancer. Clin Cancer Res. 2017;23:6863-6874 pubmed publisher
    b>Purpose: Inactivation of mismatch repair (MMR) genes may predict sensitivity to immunotherapy in metastatic prostate cancers. We studied primary prostate tumors with MMR defects...
  63. Nic Lochlainn L, Woudenberg T, van Lier A, Zonnenberg I, Philippi M, de Melker H, et al. A novel measles outbreak control strategy in the Netherlands in 2013-2014 using a national electronic immunization register: A study of early MMR uptake and its determinants. Vaccine. 2017;35:5828-5834 pubmed publisher
    ..in 2013-2014, infants aged 6-14months living in municipalities with low (<90%) measles-mumps-rubella (MMR) coverage were individually invited for an early MMR using the national electronic immunization register, Præ..
  64. Soares B, Brant A, Gomes R, Pastor T, Schneider N, Ribeiro dos Santos A, et al. Screening for germline mutations in mismatch repair genes in patients with Lynch syndrome by next generation sequencing. Fam Cancer. 2018;17:387-394 pubmed publisher
    ..772 times, respectively. Ninety-four variants were found in exons and flanking intron/exon regions for the four MMR genes. Twenty-five were pathogenic or VUS and found in 32 patients (7 in MSH2, 5 in MSH6, 12 in MLH1 e 1 in PMS2)...
  65. Caldwell R, Lane K, Shepherd V. HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription. Arch Biochem Biophys. 2006;449:27-33 pubmed
    ..Finally, two inhibitors of cyclin-dependent kinase 9 (a dominant negative CDK9 and flavopiridol) repressed activity from the MR and BMPR2 promoters. ..
  66. Arce Mendoza A, Rodriguez de Ita J, Salinas Carmona M, Rosas Taraco A. Expression of CD64, CD206, and RAGE in adherent cells of diabetic patients infected with Mycobacterium tuberculosis. Arch Med Res. 2008;39:306-11 pubmed publisher
    CD64 and CD206 receptors play an important role in the internalization of Mycobacterium tuberculosis into macrophages. RAGE, described in diabetes (a predisposing factor for tuberculosis), captures glycosylated proteins...
  67. Haralambieva I, Ovsyannikova I, Kennedy R, Larrabee B, Zimmermann M, Grill D, et al. Genome-wide associations of CD46 and IFI44L genetic variants with neutralizing antibody response to measles vaccine. Hum Genet. 2017;136:421-435 pubmed publisher
    ..We identified two distinct chromosome 1 regions (previously associated with MMR-related febrile seizures), associated with vaccine-induced measles neutralizing antibody titers...
  68. Boels M, Koudijs A, Avramut M, Sol W, Wang G, van Oeveren Rietdijk A, et al. Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy. Am J Pathol. 2017;187:2430-2440 pubmed publisher
    ..However, the CD206+/Mac3+ cell ratio, as an index of presence of anti-inflammatory macrophages, increased in ..
  69. Ren Y, Qian P, Duan Z, Zhao Z, Pan J, Yang M. Disparities in health system input between minority and non-minority counties and their effects on maternal mortality in Sichuan province of western China. BMC Public Health. 2017;17:750 pubmed publisher
    The maternal mortality rate (MMR) markedly decreased in China, but there has been a significant imbalance among different geographic regions (east, central and west regions), and the mortality in the western region remains high...
  70. Head R, Fay M, Cosgrove L, Y C Fung K, Rundle Thiele D, Martin J. Persistence of DNA adducts, hypermutation and acquisition of cellular resistance to alkylating agents in glioblastoma. Cancer Biol Ther. 2017;:1-10 pubmed publisher
    ..This activates the mismatch repair (MMR) process inducing apoptosis and mutagenesis...
  71. Kim S, Klempner S, Park S, Park J, Park Y, Lim H, et al. Correlating programmed death ligand 1 (PD-L1) expression, mismatch repair deficiency, and outcomes across tumor types: implications for immunotherapy. Oncotarget. 2017;8:77415-77423 pubmed publisher
    ..We prospectively conducted PD-L1 and MMR immunohistochemistry (IHC) on 430 consecutive patients with advanced gastrointestinal (GI) cancers, genitourinary (..
  72. Lee J, Kam E, Kim S, Cheon S, Kim E, Chung S, et al. Erythropoietin Attenuates Postoperative Cognitive Dysfunction by Shifting Macrophage Activation toward the M2 Phenotype. Front Pharmacol. 2017;8:839 pubmed publisher
    ..macrophages/microglia expressing an M1 surface marker (CD40) and increased those expressing an M2 surface marker (CD206). Arginase inhibition abolished the beneficial effects of EPO on POCD...
  73. Belfield E, Ding Z, Jamieson F, Visscher A, Zheng S, Mithani A, et al. DNA mismatch repair preferentially protects genes from mutation. Genome Res. 2017;: pubmed publisher
    ..errors subsequently evade correction by cellular DNA repair, for example, by the well-known DNA mismatch repair (MMR) mechanism. Here, we determine the genome-wide effects of MMR on mutation...
  74. Peltomäki P. Update on Lynch syndrome genomics. Fam Cancer. 2016;15:385-93 pubmed publisher
    Four main DNA mismatch repair (MMR) genes have been identified, MLH1, MSH2, MSH6, and PMS2, which when mutated cause susceptibility to Lynch syndrome (LS)...
  75. Sychareun V, Somphet V, Chaleunvong K, Hansana V, Phengsavanh A, Xayavong S, et al. Perceptions and understandings of pregnancy, antenatal care and postpartum care among rural Lao women and their families. BMC Pregnancy Childbirth. 2016;16:245 pubmed publisher
    Lao People's Democratic Republic (Lao PDR) has the highest maternal mortality rate (MMR) and infant mortality rate (IMR) due to traditional practice and beliefs on pregnancy, delivery and postpartum...
  76. Wada T, Ishikawa A, Watanabe E, Nakamura Y, Aruga Y, Hasegawa H, et al. Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance. J Endocrinol. 2017;235:179-191 pubmed publisher
    ..adipose tissue (eWAT), eplerenone prevented obesity-induced accumulation of F4/80+CD11c+CD206--M1-adipose tissue macrophage (ATM) and reduction of F4/80+CD11c-CD206+..
  77. Liu D, Morales F, Iglayreger H, Treutelaar M, Rothberg A, Hubal M, et al. Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. Appl Physiol Nutr Metab. 2017;: pubmed publisher
    ..Results Expression levels of macrophage genes (CD68, CD11b, CD206, CD16, CD40, and CD163) were lower in skeletal muscle tissue of obese versus lean participants...
  78. Murai N, Ohtaki H, Watanabe J, Xu Z, Sasaki S, Yagura K, et al. Intrapancreatic injection of human bone marrow-derived mesenchymal stem/stromal cells alleviates hyperglycemia and modulates the macrophage state in streptozotocin-induced type 1 diabetic mice. PLoS ONE. 2017;12:e0186637 pubmed publisher
    ..We found a decrease of Iba1-positive cells in islets and an increase of CD206-positive cells in both the endocrine and exocrine pancreas...
  79. Saha B, Momen Heravi F, Fűri I, Kodys K, Catalano D, Gangopadhyay A, et al. Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation via Hsp90. Hepatology. 2017;: pubmed publisher
    ..inflammatory/M1) KCs and infiltrating monocytes (F4/80int CD11bhi ) while the percentage of CD206+ CD163+ (anti-inflammatory/M2) KCs was decreased...
  80. Xaplanteri P, Lagoumintzis G, Dimitracopoulos G, Paliogianni F. Synergistic regulation of Pseudomonas aeruginosa-induced cytokine production in human monocytes by mannose receptor and TLR2. Eur J Immunol. 2009;39:730-40 pubmed publisher
    ..aeruginosa. The studies provide the first demonstration of a significant role for MR, synergistic with TLR2, in activating a proinflammatory response to P. aeruginosa infection. ..
  81. de Silva R, Dasanayake W, Wickramasinhe G, Karunatilake C, Weerasinghe N, Gunasekera P, et al. Sensitization to bovine serum albumin as a possible cause of allergic reactions to vaccines. Vaccine. 2017;35:1494-1500 pubmed publisher
    ..type hypersensitivity to vaccines containing bovine/porcine excipients, such as the measles, mumps and rubella (MMR) vaccine is probably due to sensitization to bovine/porcine gelatin...
  82. Fang X, Sun D, Wang Z, Yu Z, Liu W, Pu Y, et al. MiR-30a Positively Regulates the Inflammatory Response of Microglia in Experimental Autoimmune Encephalomyelitis. Neurosci Bull. 2017;33:603-615 pubmed publisher
    ..the expression of IL-1? and iNOS, which are pro-inflammatory, while inhibiting the expression of Ym-1 and CD206. Mechanistically, miR-30a inhibited the expression of Ppargc1b, which is the co-activator of peroxisome ..
  83. Bengtsson D, Joost P, Aravidis C, Askmalm Stenmark M, Backman A, Melin B, et al. Corticotroph Pituitary Carcinoma in a Patient With Lynch Syndrome (LS) and Pituitary Tumors in a Nationwide LS Cohort. J Clin Endocrinol Metab. 2017;102:3928-3932 pubmed publisher
    ..LS) is a cancer-predisposing syndrome caused by germline mutations in genes involved in DNA mismatch repair (MMR). Patients are at high risk for several types of cancer, but pituitary tumors have not previously been reported...
  84. Zetner D, Bisgaard M. Familial Colorectal Cancer Type X. Curr Genomics. 2017;18:341-359 pubmed publisher
    ..unknown for the 50-60% of the HNPCC families, who fulfill the Amsterdam criteria, but do not have a mutation in an MMR gene, and is referred to as FCCTX...
  85. Scodeller P, Simón Gracia L, Kopanchuk S, Tobi A, Kilk K, Säälik P, et al. Precision Targeting of Tumor Macrophages with a CD206 Binding Peptide. Sci Rep. 2017;7:14655 pubmed publisher
    Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse...
  86. Leicher L, Lammertink M, Offerman S, Morreau H, de Jong M, de Groot J, et al. Consequences of testing for mismatch repair deficiency of colorectal cancer in clinical practice. Scand J Gastroenterol. 2017;:1-5 pubmed publisher
    ..Outcome of MMR-deficiency testing is important for surgical decisions as extended colectomy is recommended in young LS-patients ..
  87. Rajaram M, Brooks M, Morris J, Torrelles J, Azad A, Schlesinger L. Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor gamma linking mannose receptor recognition to regulation of immune responses. J Immunol. 2010;185:929-42 pubmed publisher
    ..tuberculosis, with PPARgamma activation, which regulates the macrophage inflammatory response, thereby playing a role in tuberculosis pathogenesis. ..
  88. Sorvillo N, Pos W, van den Berg L, Fijnheer R, Martinez Pomares L, Geijtenbeek T, et al. The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells. Blood. 2012;119:3828-35 pubmed publisher
    ..The results of the present study indicate that sugar moieties on ADAMTS13 interact with MR, thereby promoting its endocytosis by APCs. ..
  89. Dziki J, Wang D, Pineda C, Sicari B, Rausch T, Badylak S. Solubilized extracellular matrix bioscaffolds derived from diverse source tissues differentially influence macrophage phenotype. J Biomed Mater Res A. 2017;105:138-147 pubmed publisher
    ..express a predominant M2-like macrophage phenotype, which is pro-remodeling and anti-inflammatory (iNOS-/Fizz1+/CD206+)...
  90. Zhang A, Qian Y, Ye Z, Chen H, Xie H, Zhou L, et al. Cancer-associated fibroblasts promote M2 polarization of macrophages in pancreatic ductal adenocarcinoma. Cancer Med. 2017;6:463-470 pubmed publisher
    ..of CAFs conditioned medium (CM) or direct co-culture with CAFs, monocytes exhibited enhanced expression of CD206 and CD163 compared with control group (P < 0.01)...
  91. Oesterle S, Gerngross D, Schmitt S, Roberts T, Panke S. Efficient engineering of chromosomal ribosome binding site libraries in mismatch repair proficient Escherichia coli. Sci Rep. 2017;7:12327 pubmed publisher
    ..when integrating the library by CRISPR/Cas9-based genome editing is severely restricted by DNA mismatch repair (MMR) systems...
  92. Salazar F, Hall L, Negm O, Awuah D, Tighe P, Shakib F, et al. The mannose receptor negatively modulates the Toll-like receptor 4-aryl hydrocarbon receptor-indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization. J Allergy Clin Immunol. 2016;137:1841-1851.e2 pubmed publisher
    ..Our work demonstrates a key role for MR in the modulation of the TLR4-AhR-IDO axis, which has a significant effect on DC behavior and the development of immune responses against allergens. ..