MPZ

Summary

Gene Symbol: MPZ
Description: myelin protein zero
Alias: CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, myelin protein P0, Charcot-Marie-Tooth neuropathy 1B, myelin peripheral protein
Species: human
Products:     MPZ

Top Publications

  1. Su Y, Brooks D, Li L, Lepercq J, Trofatter J, Ravetch J, et al. Myelin protein zero gene mutated in Charcot-Marie-tooth type 1B patients. Proc Natl Acad Sci U S A. 1993;90:10856-60 pubmed
    Autosomal dominant of Charcot-Marie-Tooth disease (CMT), whose gene is type 1B (CMT1B), has slow nerve conduction with demyelinated Schwann cells...
  2. Hilmi S, Fournier M, Valeins H, Gandar J, Bonnet J. Myelin P0 glycoprotein: identification of the site phosphorylated in vitro and in vivo by endogenous protein kinases. J Neurochem. 1995;64:902-7 pubmed
    ..Our results strongly suggest that the phosphorylation of these serine residues alters the secondary structure of this domain. Such a structural perturbation could play an important role in myelin compaction at the dense line level. ..
  3. Nelis E, Haites N, Van Broeckhoven C. Mutations in the peripheral myelin genes and associated genes in inherited peripheral neuropathies. Hum Mutat. 1999;13:11-28 pubmed
    ..e., Charcot-Marie-Tooth disease type 1 (CMT1) and type 2 (CMT2), Dejerine-Sottas syndrome (DSS), hereditary neuropathy with liability to pressure palsies (HNPP),..
  4. Shy M. Peripheral neuropathies caused by mutations in the myelin protein zero. J Neurol Sci. 2006;242:55-66 pubmed
    Charcot-Marie-Tooth disease type 1B (CMT1B) is caused by mutations in the major PNS myelin protein myelin protein zero (MPZ)...
  5. Schneider Gold C, Kötting J, Epplen J, Gold R, Gerding W. Unusual Charcot-Marie-Tooth phenotype due to a mutation within the intracellular domain of myelin protein zero. Muscle Nerve. 2010;41:550-4 pubmed publisher
    Myelin protein zero (MPZ/P0) constitutes a major component of compact peripheral myelin. We report a family with a missense mutation, c.700G>T p.Asp234Tyr (deviant nomenclature: c.670G>T, p...
  6. Shy M, Jani A, Krajewski K, Grandis M, Lewis R, Li J, et al. Phenotypic clustering in MPZ mutations. Brain. 2004;127:371-84 pubmed
    ..MPZ mutations in humans cause the inherited demyelinating neuropathy CMT1B. Some mutations cause the severe neuropathies of infancy designated as Dejerine-Sottas disease, while others cause ..
  7. Grandis M, Vigo T, Passalacqua M, Jain M, Scazzola S, La Padula V, et al. Different cellular and molecular mechanisms for early and late-onset myelin protein zero mutations. Hum Mol Genet. 2008;17:1877-89 pubmed publisher
    ..encoding myelin protein zero (MPZ), cause inherited neuropathies collectively called Charcot-Marie-Tooth type 1B (CMT1B)...
  8. Roa B, Warner L, Garcia C, Russo D, Lovelace R, Chance P, et al. Myelin protein zero (MPZ) gene mutations in nonduplication type 1 Charcot-Marie-Tooth disease. Hum Mutat. 1996;7:36-45 pubmed
    ..in the MPZ gene are associated with the demyelinating peripheral neuropathies Charcot-Marie-Tooth disease type 1B (CMT1B), and the more severe Dejerine-Sottas syndrome (DSS)...
  9. Warner L, Hilz M, Appel S, Killian J, Kolodry E, Karpati G, et al. Clinical phenotypes of different MPZ (P0) mutations may include Charcot-Marie-Tooth type 1B, Dejerine-Sottas, and congenital hypomyelination. Neuron. 1996;17:451-60 pubmed
    ..zero (MPZ) gene, encoding the major structural protein (P0) of peripheral nerve myelin, in patients with either CMT1B, DSS, or CH...

More Information

Publications134 found, 100 shown here

  1. Hayasaka K, Himoro M, Sato W, Takada G, Uyemura K, Shimizu N, et al. Charcot-Marie-Tooth neuropathy type 1B is associated with mutations of the myelin P0 gene. Nat Genet. 1993;5:31-4 pubmed
    ..molecule and maps to chromosome 1q22-q23, in the region of the locus for Charcot-Marie-Tooth neuropathy type 1B (CMT1B)...
  2. Fabrizi G, Tamburin S, Cavallaro T, Cabrini I, Ferrarini M, Taioli F, et al. The spectrum of Charcot-Marie-Tooth disease due to myelin protein zero: An electrodiagnostic, nerve ultrasound and histological study. Clin Neurophysiol. 2018;129:21-32 pubmed publisher
    ..nine patients were categorized as "demyelinating" CMT1B, 17 as "axonal" CMT2I/J, and 10 as dominant "intermediate" CMTDID. Sural nerve biopsy showed hypertrophic de-remyelinating neuropathy with numerous complex onion bulbs in one ..
  3. Xu W, Zhu H, Shen Y, Wan Y, Tu X, Wu W, et al. DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice. Mol Cell Biol. 2018;38: pubmed publisher
    ..Subsequently, elevated insulin regulates myelin protein zero (Mpz) transcription in Schwann cells via upregulating the expression of early growth response 2 (Egr2), leading to ..
  4. Son D, Kang P, Yun W, You S. Generation of induced pluripotent stem cell (iPSC) line from Charcot-Marie-Tooth disease patient with MPZ mutation (CMT1B). Stem Cell Res. 2017;24:5-7 pubmed publisher
    Charcot-Marie-Tooth disease (CMT1B) is an inherited neurological disorder caused by mutation of the myelin protein zero (MPZ) gene...
  5. Maeda Y, Fukushima K, Kariya S, Orita Y, Nishizaki K. Dexamethasone Regulates Cochlear Expression of Deafness-associated Proteins Myelin Protein Zero and Heat Shock Protein 70, as Revealed by iTRAQ Proteomics. Otol Neurotol. 2015;36:1255-65 pubmed publisher
    ..One protein, myelin protein zero (Mpz), was upregulated (1.870 ± 0.201-fold change, p < 0...
  6. Schmid D, Zeis T, Sobrio M, Schaeren Wiemers N. MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells. ASN Neuro. 2014;6: pubmed publisher
    ..which is evident by a delayed onset of myelination and reduced expression of the myelin protein zero (Mpz/P0) and the low-affinity neurotrophin receptor p75(NTR)...
  7. Cardona Pemberthy V, Rendón M, Beltrán J, Soto Ospina A, Muñoz Gomez A, Araque Marín P, et al. Genetic variants, structural, and functional changes of Myelin Protein Zero and Mannose-Binding Lectin 2 protein involved in immune response and its allelic transmission in families of patients with leprosy in Colombia. Infect Genet Evol. 2018;61:215-223 pubmed publisher
    ..We studied genetic variants Myelin Protein Zero (MPZ), a major structural component of the myelin sheath, and Mannose Binding Lectin 2 (MBL2), a protein involved in ..
  8. Sidoli M, Musner N, Silvestri N, Ungaro D, D Antonio M, Cavener D, et al. Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse. J Neurosci. 2016;36:11350-11361 pubmed
    ..in the endoplasmic reticulum (ER) of Schwann cells and a persistent UPR associated with Charcot-Marie-Tooth 1B (CMT1B) demyelinating peripheral neuropathy in human and mouse...
  9. Patzig J, Kusch K, Fledrich R, Eichel M, Lüders K, Möbius W, et al. Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking. Glia. 2016;64:155-74 pubmed publisher
    ..neuropathy with secondary axonal degeneration in humans with the neuropathy Dejerine-Sottas syndrome (DSS) and in the corresponding mouse model (P0(null)-mice)...
  10. Torii T, Ohno N, Miyamoto Y, Kawahara K, Saitoh Y, Nakamura K, et al. Arf6 guanine-nucleotide exchange factor cytohesin-2 regulates myelination in nerves. Biochem Biophys Res Commun. 2015;460:819-25 pubmed publisher
    ..and reduced myelin thickness in the sciatic nerves, with decreased expression levels of myelin protein zero (MPZ), the major myelin marker protein...
  11. Katsel P, Fam P, Tan W, Khan S, Yang C, Jouroukhin Y, et al. Overexpression of Truncated Human DISC1 Induces Appearance of Hindbrain Oligodendroglia in the Forebrain During Development. Schizophr Bull. 2017;: pubmed publisher
    ..of OLG and upregulation of hindbrain mature OLG markers (laminin alpha-1 [LAMA1] and myelin protein zero [MPZ]) suggesting a suppressive function of endogenous DISC1 in OLG specialization of hindbrain glial progenitors during ..
  12. Martins D, Dos Santos F, Ciena A, Watanabe I, de Britto L, Lemos J, et al. Neuropeptide expression and morphometric differences in crushed alveolar inferior nerve of rats: Effects of photobiomodulation. Lasers Med Sci. 2017;32:833-840 pubmed publisher
    ..data of the IAN using TEM and by the expression of laminin, neurofilaments (NFs), and myelin protein zero (MPZ) using Western blot analysis...
  13. De Bellard M. Myelin in cartilaginous fish. Brain Res. 2016;1641:34-42 pubmed publisher
    ..from the one observed in tetrapods and the first true myelin basic protein (MBP) and myelin protein zero (MPZ) seem to have originated on cartilaginous fish or their ancestors, the placoderms...
  14. Madej Pilarczyk A, Kotruchow K, Kabzinska D, Cegielska J, Kochanski A, Hausmanowa Petrusewicz I. Emery-Dreifuss muscular dystrophy type 2 associated (?) with mild peripheral polyneuropathy. Folia Neuropathol. 2015;53:270-4 pubmed publisher
    ..induced differentiation-associated protein 1 (GDAP1), gap junction β-1 protein (GJB1), and myelin protein zero (MPZ) genes did not reveal mutations; however, we identified a new sequence intronic variant in the mitofusin 2 (MFN2) ..
  15. Jouaud M, Gonnaud P, Richard L, Latour P, Ollagnon Roman E, Sturtz F, et al. Congenital hypomyelinating neuropathy due to the association of a truncating mutation in PMP22 with the classical HNPP deletion. Neuromuscul Disord. 2016;26:316-21 pubmed publisher
    ..Mutations involve genes such as myelin protein zero (MPZ), peripheral myelin protein 22 (PMP22), and early growth response 2 (EGR2)...
  16. Fu J, Dai S, Lu Y, Wu R, Wang Z, Yuan Y, et al. Similar clinical, pathological, and genetic features in Chinese patients with autosomal recessive and dominant Charcot-Marie-Tooth disease type 2K. Neuromuscul Disord. 2017;27:760-765 pubmed publisher
    ..CMT2K is an axonal neuropathy while CMT4A is a demyelinating type. In a series of 169 Chinese CMT patients (79 CMT1, 52 CMT2 and 38 unclassified), four unrelated patients (2...
  17. Hong Y, Joo J, Hyun Y, Kwak G, Choi Y, Yeo H, et al. A Mutation in PMP2 Causes Dominant Demyelinating Charcot-Marie-Tooth Neuropathy. PLoS Genet. 2016;12:e1005829 pubmed publisher
    ..The relevance of PMP2 mutation as a genetic cause of dominant CMT1 was assessed using transgenic mouse models. Transgenic mice expressing wild type or mutant (p...
  18. Zhan Y, Zi X, Hu Z, Peng Y, Wu L, Li X, et al. PMP22-Related neuropathies and other clinical manifestations in Chinese han patients with charcot-marie-tooth disease type 1. Muscle Nerve. 2015;52:69-75 pubmed publisher
    ..and polymerase chain reaction-restriction fragment length polymorphism methods in 77 Chinese Han families with CMT1. PMP22 sequencing was performed in MLPA-negative probands...
  19. Chumakov I, Milet A, Cholet N, Primas G, Boucard A, Pereira Y, et al. Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy. Orphanet J Rare Dis. 2014;9:201 pubmed publisher
    ..ability to lower Pmp22 mRNA in Schwann cells relative to house-keeping genes or to a second myelin transcript (Mpz) was assessed in a clonal cell line expressing these genes...
  20. Musner N, Sidoli M, Zambroni D, Del Carro U, Ungaro D, D Antonio M, et al. Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy. ASN Neuro. 2016;8: pubmed publisher
    ..accumulates in the ER lumen and induces a demyelinating neuropathy in Charcot-Marie-Tooth disease type 1B (CMT1B)-S63del mice. Accumulation of P0S63del in the ER triggers a persistent unfolded protein response...
  21. Klein D, Patzkó Ã, Schreiber D, van Hauwermeiren A, Baier M, Groh J, et al. Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice. Brain. 2015;138:3193-205 pubmed publisher
    ..another model mimicking a mild, demyelination-related Charcot-Marie-Tooth type 1 neuropathy caused by reduced P0 (MPZ) gene dosage, macrophage blockade causes an improved preservation of myelin, increased muscle action potential ..
  22. van Doormaal T, van Ruissen F, Miller K, Hoogendijk J. Effective cauda equina decompression in two siblings with Charcot-Marie-Tooth disease type 1B. Neuromuscul Disord. 2016;26:837-840 pubmed publisher
    Two siblings with Charcot-Marie-Tooth (CMT) 1B due to a c.517G>C (p.Gly173Arg) mutation in the MPZ gene both developed an acute cauda syndrome with unbearable back pain radiating to both legs, progressive muscle weakness of the legs, ..
  23. Berciano J, García A, Gallardo E, Peeters K, Pelayo Negro A, Álvarez Paradelo S, et al. Intermediate Charcot-Marie-Tooth disease: an electrophysiological reappraisal and systematic review. J Neurol. 2017;264:1655-1677 pubmed publisher
    ..According to median motor nerve conduction velocity (MNCV), CMT is divided into demyelinating (CMT1) with MNCV below 38 m/s, axonal (CMT2) with MNCV above 38 m/s, and intermediate CMT with MNCV between 25 and ..
  24. Morris K, Castillo E, Ray A, Weston L, Nofchissey R, Hanson J, et al. Anti-G-CSF treatment induces protective tumor immunity in mouse colon cancer by promoting protective NK cell, macrophage and T cell responses. Oncotarget. 2015;6:22338-47 pubmed
    ..C57BL/6 mice treated with azoxymethane/dextran sodium sulfate (AOM/DSS) to induce neoplasms were administered anti-G-CSF or isotype control antibodies three times a week for three weeks...
  25. Okuda K, Misa J, Oehlers S, Hall C, Ellett F, Alasmari S, et al. A zebrafish model of inflammatory lymphangiogenesis. Biol Open. 2015;4:1270-80 pubmed publisher
    ..challenge stimulated by exposure to 2,4,6-trinitrobenzenesulfonic acid (TNBS) or dextran sodium sulphate (DSS)...
  26. Obata T, Nakashima M. Opening of ATP-sensitive K(+) (KATP) channels enhance hydroxyl radical generation induced by MPP(+) in rat striatum. J Neurol Sci. 2016;366:180-183 pubmed publisher
    ..opening of adenosine triphosphate (ATP) sensitive K(+) (KATP) channels can enhance 1-methyl-4-phenylpyridinium (MPP(+))-induced hydroxyl radical (OH) generation in rat striatum...
  27. Wang Q, Jiao F, Zhang P, Yan J, Zhang Z, He F, et al. CDK5-Mediated Phosphorylation-Dependent Ubiquitination and Degradation of E3 Ubiquitin Ligases GP78 Accelerates Neuronal Death in Parkinson's Disease. Mol Neurobiol. 2018;55:3709-3717 pubmed publisher
    ..Importantly, overexpression of GP78 or interference of GP78 Ser516 phosphorylation protected neurons against MPP+-induced cell death...
  28. Tang L, Untch B, Reidy D, O Reilly E, Dhall D, Jih L, et al. Well-Differentiated Neuroendocrine Tumors with a Morphologically Apparent High-Grade Component: A Pathway Distinct from Poorly Differentiated Neuroendocrine Carcinomas. Clin Cancer Res. 2016;22:1011-7 pubmed publisher
    ..The median disease-specific survival (DSS) was 55 months (16-119 months), and 2-year and 5-year DSS was 88% and 49%, respectively-significantly better than ..
  29. Wang C, Yu C, Wen X, Chen L, Zhang C, Calway T, et al. American Ginseng Attenuates Colitis-Associated Colon Carcinogenesis in Mice: Impact on Gut Microbiota and Metabolomics. Cancer Prev Res (Phila). 2016;9:803-811 pubmed
    ..induced colitis and colon carcinogenesis were evaluated using an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model...
  30. Crombie A, Farah C, Tripcony L, Dickie G, Batstone M. Primary chemoradiotherapy for oral cavity squamous cell carcinoma. Oral Oncol. 2012;48:1014-1018 pubmed publisher
    ..TNM staging system), Type of Chemotherapy and Dose of RT, Overall Survival (OS) and Disease-Specific Survival (DSS), Attempt at Salvage, development of distant metastases, development of ORN and success of treatment for ORN and ..
  31. Matsuoka Y, Takagi Y, Nosaka K, Sakabe T, Haruki T, Araki K, et al. Cytoplasmic expression of maspin predicts unfavourable prognosis in patients with squamous cell carcinoma of the lung. Histopathology. 2016;69:114-20 pubmed publisher
    ..50 months), and the maspin-positive group had shorter disease-free survival (DFS) and disease-specific survival (DSS) by log-rank test (P = 0.002, P = 0.016, respectively)...
  32. Heinsch S, Otto Hanson L, Hsu S, Kinkel L, Smanski M. Genome Sequences for Streptomyces spp. Isolated from Disease-Suppressive Soils and Long-Term Ecological Research Sites. Genome Announc. 2017;5: pubmed publisher
    ..i>Streptomyces sp. strain GS93-23 was isolated from naturally disease-suppressive soil (DSS) in Grand Rapids, MN, and Streptomyces sp...
  33. Liu W, Zhou F, Wang Y, Wang T, Xing J, Zhang S, et al. Voluntary exercise protects against ulcerative colitis by up-regulating glucocorticoid-mediated PPAR-γ activity in the colon in mice. Acta Physiol (Oxf). 2015;215:24-36 pubmed publisher
    ..exercise would attenuate colonic inflammation and ameliorate clinical symptoms in dextran sulphate sodium (DSS)-induced ulcerative colitis by increasing glucocorticoid production and up-regulating PPAR-γ activity in the ..
  34. Zhang Z, Yu H, Jiang S, Liao J, Lu T, Wang L, et al. Evidence for Association of Cell Adhesion Molecules Pathway and NLGN1 Polymorphisms with Schizophrenia in Chinese Han Population. PLoS ONE. 2015;10:e0144719 pubmed publisher
    ..04×10-6). Moreover, 12 genes (HLA-A, HLA-C, HLA-DOB, HLA-DPB1, HLA-DQA2, HLA-DRB1, MPZ, CD276, NLGN1, NRCAM, CLDN1 and ICAM3) were modestly significantly associated with schizophrenia (P<0.01)...
  35. Bae W, Choi J, Jeong J. The Neuroprotective Effects of Cinnamic Aldehyde in an MPTP Mouse Model of Parkinson's Disease. Int J Mol Sci. 2018;19: pubmed publisher
    ..Finally, we showed that blockage of autophagy using autophagy inhibitors protected the 1-methyl-4-phenylpyridinium (MPP?)-mediated death of BE(2)-M17 cells...
  36. Bakhtiari A, Hematian A, Sharifi A. Energy analyses and greenhouse gas emissions assessment for saffron production cycle. Environ Sci Pollut Res Int. 2015;22:16184-201 pubmed publisher
    ..Sensitivity analysis results of the energy inputs demonstrated that the marginal physical productivity (MPP) worth of electricity energy was the highest for saffron stigma and corm, although saffron flower and leaf had more ..
  37. Achiwa K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hayashi K, et al. DSS colitis promotes tumorigenesis and fibrogenesis in a choline-deficient high-fat diet-induced NASH mouse model. Biochem Biophys Res Commun. 2016;470:15-21 pubmed publisher
    ..Moreover, in a dextran sodium sulfate (DSS)-induced colitis model in mice, a high-fat diet increases portal LPS level and promotes hepatic inflammation and ..
  38. Jeitner T, Kalogiannis M, Krasnikov B, Gomolin I, Peltier M, Moran G. Linking Inflammation and Parkinson Disease: Hypochlorous Acid Generates Parkinsonian Poisons. Toxicol Sci. 2016;151:388-402 pubmed publisher
    ..that were comparable to those produced by the same dose of the parkinsonian poison, 1-methyl-4-phenylpyridinium (MPP+). Chlorodopamine was also more toxic to differentiated SH SY5Y cells than HOCl...
  39. Tay G, Iyer N, Ong W, Tai D, Ang M, Ha T, et al. Outcomes and Prognostic Factors of Radiation-Induced and De Novo Head and Neck Squamous Cell Carcinomas. Otolaryngol Head Neck Surg. 2016;154:880-7 pubmed publisher
    ..67 vs 5.03 years; P = .018) and disease-specific survival (DSS) (median, 1.67 vs 8.65 years; P = .001) than those with DNSCC...
  40. Agrahari A, George Priya Doss C. Impact of I30T and I30M substitution in MPZ gene associated with Dejerine-Sottas syndrome type B (DSSB): A molecular modeling and dynamics. J Theor Biol. 2015;382:23-33 pubmed publisher
    Myelin protein zero (MPZ) gene encodes MPZ protein is a vital component of the myelin sheath...
  41. Dos Santos Carmo A, Suzuki R, Riquena M, Eterovic A, Sperança M. Maintenance of demographic and hematological profiles in a long-lasting dengue fever outbreak: implications for management. Infect Dis Poverty. 2016;5:84 pubmed publisher
    ..faulty diagnosis in patients, who might later undergo dengue hemorrhagic fever (DHF) and the dengue-shock syndrome (DSS)...
  42. Zhang Q, Zhang C, Chang F, Liang K, Yin X, Li X, et al. Wip 1 inhibits intestinal inflammation in inflammatory bowel disease. Cell Immunol. 2016;310:63-70 pubmed publisher
    ..Expression of Wip 1 was analyzed after the cells were stimulated by various of cytokines. DSS-colitis model was induced on the wild type (WT) and Wip 1 knock out (Wip1-/-) mice, and cytokines ..
  43. Liu Y, Xiong S, Sun W, Zou F. Joint Analysis of Strain and Parent-of-Origin Effects for Recombinant Inbred Intercrosses Generated from Multiparent Populations with the Collaborative Cross as an Example. G3 (Bethesda). 2018;8:599-605 pubmed publisher
    Multiparent populations (MPP) have become popular resources for complex trait mapping because of their wider allelic diversity and larger population size compared with traditional two-way recombinant inbred (RI) strains...
  44. Luigetti M, Fabrizi G, Bisogni G, Romano A, Taioli F, Ferrarini M, et al. Charcot-Marie-Tooth type 2 and distal hereditary motor neuropathy: Clinical, neurophysiological and genetic findings from a single-centre experience. Clin Neurol Neurosurg. 2016;144:67-71 pubmed publisher
    CMT is a group of heterogeneous motor and sensory neuropathies divided into demyelinating (CMT1) and axonal forms (CMT2). Distal Hereditary Motor Neuropathy (dHMN) is a motor neuropathy/neuronopathy which resembles CMT...
  45. Huang E, Liu R, Lu Z, Liu J, Liu X, Zhang D, et al. NKT cells mediate the recruitment of neutrophils by stimulating epithelial chemokine secretion during colitis. Biochem Biophys Res Commun. 2016;474:252-258 pubmed publisher
    ..In our research, we found that the NKT cell-deficient CD1d(-/-) mice had relieved colitis in the DSS-induced colitis model...
  46. Li J, Chen H, Wu S, Cheng Y, Li Q, Wang J, et al. MPP+ inhibits mGluR1/5-mediated long-term depression in mouse hippocampus by calpain activation. Eur J Pharmacol. 2017;795:22-27 pubmed publisher
    ..In this study, we reported a novel effect of neurotoxin, 1-methyl-4-phenylpyridinium (MPP+), on metabotropic glutamate receptor 1/5 agonist, 3,5-dihydroxyphenylglycine (DHPG)-induced hippocampal ..
  47. Cohen J, Reymond E, Medici M, Lederlin M, Lantuejoul S, Laurent F, et al. CT-texture analysis of subsolid nodules for differentiating invasive from in-situ and minimally invasive lung adenocarcinoma subtypes. Diagn Interv Imaging. 2018;99:291-299 pubmed publisher
    ..followed by histogram quantification using mean intensity, standard deviation (SD), entropy, mean positive pixels (MPP), skewness and kurtosis...
  48. Antonellis A, Dennis M, Burzynski G, Huynh J, Maduro V, Hodonsky C, et al. A rare myelin protein zero (MPZ) variant alters enhancer activity in vitro and in vivo. PLoS ONE. 2010;5:e14346 pubmed publisher
    Myelin protein zero (MPZ) is a critical structural component of myelin in the peripheral nervous system. The MPZ gene is regulated, in part, by the transcription factors SOX10 and EGR2...
  49. Shmuel Galia L, Aychek T, Fink A, Porat Z, Zarmi B, Bernshtein B, et al. Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis. EMBO J. 2016;35:685-98 pubmed publisher
    ..that inhibition of Toll-like receptor 2(TLR2) dimerization by a TLR2 transmembrane peptide (TLR2-p) ameliorated DSS-induced colitis by interfering specifically with the activation of Ly6C(+) monocytes without affecting their ..
  50. Marelli G, Belgiovine C, Mantovani A, Erreni M, Allavena P. Non-redundant role of the chemokine receptor CX3CR1 in the anti-inflammatory function of gut macrophages. Immunobiology. 2017;222:463-472 pubmed publisher
    ..mice proficient or deficient for the expression of the CX3CR1 receptor in a model of dextran sulphate sodium (DSS) induced acute colitis...
  51. Hasse B, Bosse F, Hanenberg H, Müller H. Peripheral myelin protein 22 kDa and protein zero: domain specific trans-interactions. Mol Cell Neurosci. 2004;27:370-8 pubmed
    ..In addition, we demonstrate that disease-related point mutations of P0 resulted in a decreased adhesion capability correlating with the severity of the respective disease phenotype. ..
  52. Corrado L, Magri S, Bagarotti A, Carecchio M, Piscosquito G, Pareyson D, et al. A novel synonymous mutation in the MPZ gene causing an aberrant splicing pattern and Charcot-Marie-Tooth disease type 1b. Neuromuscul Disord. 2016;26:516-20 pubmed publisher
    ..Here, we describe two CMT1B families with a mild sensory-motor neuropathy and a novel synonymous variant (c.309G > T, p...
  53. Song W, Li Q, Ryu M, Ahn J, Ha Bhang D, Chan Jung Y, et al. TSG-6 Secreted by Human Adipose Tissue-derived Mesenchymal Stem Cells Ameliorates DSS-induced colitis by Inducing M2 Macrophage Polarization in Mice. Sci Rep. 2017;7:5187 pubmed publisher
    ..In conclusion, hAT-MSC-produced TSG-6 can ameliorate IBD by inducing M2 macrophage switch in mice. ..
  54. Zurleni T, Cassiano A, Gjoni E, Ballabio A, Serio G, Marzoli L, et al. Surgical and oncological outcomes after complete mesocolic excision in right-sided colon cancer compared with conventional surgery: a retrospective, single-institution study. Int J Colorectal Dis. 2018;33:1-8 pubmed publisher
    ..Overall survival (OS) and disease-specific survival (DSS) were investigated. The median number of examined lymph nodes was 33.28 in the CME group and 26...
  55. Yancu D, Blouin M, Birman E, Florianova L, Aleynikova O, Zakikhani M, et al. A phenotype of IGFBP-3 knockout mice revealed by dextran sulfate-induced colitis. J Gastroenterol Hepatol. 2017;32:146-153 pubmed publisher
    ..The dextran sodium sulfate (DSS) murine model of ulcerative colitis was used for this study...
  56. Megwalu U, Ma Y. Racial disparities in oropharyngeal cancer survival. Oral Oncol. 2017;65:33-37 pubmed publisher
    ..The outcomes of interest were overall survival (OS) and disease-specific survival (DSS)...
  57. Skansing D, Londero S, Asschenfeldt P, Larsen S, Godballe C. Nonanaplastic follicular cell-derived thyroid carcinoma: mitosis and necrosis in long-term follow-up. Eur Arch Otorhinolaryngol. 2017;274:2541-2548 pubmed publisher
    ..In disease specific survival (DSS) age was not significant...
  58. Matsuo H, Yoshimura Y. Calf circumference is associated with dysphagia in acute-care inpatients. Geriatr Nurs. 2018;39:186-190 pubmed publisher
    ..Dysphagia and swallowing difficulty were assessed using the Dysphagia Severity Scale (DSS). Univariate and multivariate analyses were used to determine whether CC was associated with dysphagia...
  59. Piazza C, Del Bon F, Barbieri D, Grazioli P, Paderno A, Perotti P, et al. Tracheal and Crico-Tracheal Resection and Anastomosis for Malignancies Involving the Thyroid Gland and the Airway. Ann Otol Rhinol Laryngol. 2016;125:97-104 pubmed publisher
    ..Kaplan-Meier curves were used to evaluate the overall (OS) and disease-specific (DSS) survivals and local (LC) and loco-regional control (LRC)...
  60. Sanchez A, Rodríguez D, Allard C, Bechis S, Sullivan R, Boeke C, et al. Primary genitourinary melanoma: Epidemiology and disease-specific survival in a large population-based cohort. Urol Oncol. 2016;34:166.e7-14 pubmed publisher
    ..of GU melanoma with demographic, clinical, and pathologic characteristics, as well as disease-specific survival (DSS). DSS was calculated using the Kaplan-Meier method...
  61. More S, Choi D. Atractylenolide-I Protects Human SH-SY5Y Cells from 1-Methyl-4-Phenylpyridinium-Induced Apoptotic Cell Death. Int J Mol Sci. 2017;18: pubmed publisher
    ..Our study investigates the protective effects of atractylenolide-I (ATR-I) on 1-methyl-4-phenylpyridinium (MPP⁺)-induced cytotoxicity in human dopaminergic SH-SY5Y cells, as well as its underlying mechanism...
  62. Zhou J, Tan L, Xie J, Lai Z, Huang Y, Qu C, et al. Characterization of brusatol self-microemulsifying drug delivery system and its therapeutic effect against dextran sodium sulfate-induced ulcerative colitis in mice. Drug Deliv. 2017;24:1667-1679 pubmed publisher
    ..Meanwhile, the anti-colitis activity of BR-SMEDDS was evaluated on dextran sodium sulfate (DSS)-induced colitis mice model...
  63. Guo Y, Su Z, Zhang C, Gaspar J, Wang R, Hart R, et al. Mechanisms of colitis-accelerated colon carcinogenesis and its prevention with the combination of aspirin and curcumin: Transcriptomic analysis using RNA-seq. Biochem Pharmacol. 2017;135:22-34 pubmed publisher
    ..study was to determine the effect of ASA, CUR, and their combination in azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-accelerated colorectal cancer (CAC)...
  64. Villamor E, Villar L, Lozano A, Herrera V, Herrán O. Vitamin D serostatus and dengue fever progression to dengue hemorrhagic fever/dengue shock syndrome. Epidemiol Infect. 2017;145:2961-2970 pubmed publisher
    Vitamin D could modulate pathways leading to dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS)...
  65. Pergolini I, Crippa S, Salgarello M, Belfiori G, Partelli S, Ruffo G, et al. SUVmax after (18)fluoro-deoxyglucose positron emission tomography/computed tomography: A tool to define treatment strategies in pancreatic cancer. Dig Liver Dis. 2018;50:84-90 pubmed publisher
    ..Receiver operating characteristics (ROC) curves for disease-free survival (DFS) and disease-specific survival (DSS) identified SUVmax of 6.0 as optimal cut-off. Multivariate analysis showed that SUVmax ≥ 6...
  66. Aimé P, Sun X, Zareen N, Rao A, Berman Z, Volpicelli Daley L, et al. Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models. J Neurosci. 2015;35:10731-49 pubmed publisher
    ..neuronal PC12 cells and rat dopaminergic ventral midbrain neurons treated with 6-OHDA, 1-methyl-4-phenylpyridinium (MPP+), or α-synuclein fibrils (αSYN)...
  67. Knod J, Crawford K, Dusing M, Frischer J. Murine colitis treated with multitargeted tyrosine kinase inhibitors. J Surg Res. 2016;200:501-7 pubmed publisher
    ..Sorafenib, sunitinib, and axitinib were administered by oral gavage in a murine model of dextran sodium sulfate (DSS) colitis...
  68. Ryu D, Lim J, Lee S, Park G, Min C. Induction of Indoleamine 2,3-dioxygenase by Pre-treatment with Poly(I:C) May Enhance the Efficacy of MSC Treatment in DSS-induced Colitis. Immune Netw. 2016;16:358-365 pubmed publisher
    ..Mice (C57BL6) were administered with 4% dextran sulfate sodium (DSS) in drinking water for 7 days and injected with MSCs on days 1 and 3 following DSS ingestion...
  69. Postlewait L, Squires M, Kooby D, Poultsides G, Weber S, Bloomston M, et al. Preoperative Helicobacter pylori Infection is Associated with Increased Survival After Resection of Gastric Adenocarcinoma. Ann Surg Oncol. 2016;23:1225-33 pubmed publisher
    ..end points of the study were overall survival (OS), recurrence-free survival (RFS), and disease-specific survival (DSS). Of 559 patients, 104 (18.6 %) who tested positive for H. pylori were younger (62.1 vs 65...
  70. Goodman W, Omenetti S, Date D, di Martino L, De Salvo C, Kim G, et al. KLF6 contributes to myeloid cell plasticity in the pathogenesis of intestinal inflammation. Mucosal Immunol. 2016;9:1250-62 pubmed publisher
    ..role of myeloid KLF6, we treated myeloid-specific KLF6-knockout mice (Mac-KLF6-KO) with dextran sulfate sodium (DSS) and found that Mac-KLF6-KO mice were protected against chemically-induced colitis; this highlights the central ..
  71. Malmgren J, Mayer M, Atwood M, Kaplan H. Differential presentation and survival of de novo and recurrent metastatic breast cancer over time: 1990-2010. Breast Cancer Res Treat. 2018;167:579-590 pubmed publisher
    ..Disease specific survival (DSS) was time from diagnosis or distant recurrence to BC death...
  72. De Angelis M, Di Muzio A, Capasso M, Angiari C, Cavallaro T, Fabrizi G, et al. Segmental conduction abnormalities and myelin thickenings in Val102/fs null mutation of MPZ gene. Neurology. 2004;63:2180-3 pubmed
    ..The authors hypothesize that myelin thickenings at the paranodal region, in concurrence with compression at usual entrapment sites or minor repetitive trauma, may induce segmental conduction abnormalities. ..
  73. de Babos D, Bechlin M, Barros A, Ferreira E, Gomes Neto J, de Oliveira S. Cobalt internal standard for Ni to assist the simultaneous determination of Mo and Ni in plant materials by high-resolution continuum source graphite furnace atomic absorption spectrometry employing direct solid sample analysis. Talanta. 2016;152:457-62 pubmed publisher
    ..source graphite furnace atomic absorption spectrometry (HR-CS GFAAS), employing direct solid sample analysis (DSS) and internal standardization (IS)...
  74. Leal A, Berghoff C, Berghoff M, Del Valle G, Contreras C, Montoya O, et al. Charcot-Marie-Tooth disease: a novel Tyr145Ser mutation in the myelin protein zero (MPZ, P0) gene causes different phenotypes in homozygous and heterozygous carriers within one family. Neurogenetics. 2003;4:191-7 pubmed
    ..disease type 1B (CMT 1B) is caused by mutations in the gene coding for peripheral myelin protein zero (MPZ, P0) that plays a fundamental role in adhesion and compaction of peripheral myelin...
  75. Zhao L, Xiao H, Mu H, Huang T, Lin Z, Zhong L, et al. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules. 2017;22: pubmed publisher
    ..To investigate the effect of magnolol in dextran sulfate sodium (DSS)-induced experimental UC model, male C57 mice were treated with 2% DSS drinking water for 5 consecutive days ..
  76. Ricciotti R, Baraff A, Jour G, Kyriss M, Wu Y, Liu Y, et al. High amplification levels of MDM2 and CDK4 correlate with poor outcome in patients with dedifferentiated liposarcoma: A cytogenomic microarray analysis of 47 cases. Cancer Genet. 2017;218-219:69-80 pubmed publisher
    ..0168 and 0.0169 respectively) and disease specific survival (DSS) (P?=?.0082 and 0.0140 respectively)...
  77. Beier H, Grimm M. Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs. Nucleic Acids Res. 2001;29:4767-82 pubmed
    ..It is discussed that not only RNA viruses, but also the eukaryotic host organism might gain some profit from cellular suppressor tRNAs...
  78. Wagner D, Duan H, Chapron A, Lee R, Wang J. Potent inhibition of human organic cation transporter 2 (hOCT2) by ?-carboline alkaloids. Xenobiotica. 2017;47:1112-1120 pubmed publisher
    ..Beta-carbolines are structurally related to the neurotoxin 1-methyl-4-phenylpyridinium (MPP+), a known substrate of organic cation transporters (OCTs)...
  79. Martí S, León M, Orellana C, Prieto J, Ponsoda X, López García C, et al. Generation of a disease-specific iPS cell line derived from a patient with Charcot-Marie-Tooth type 2K lacking functional GDAP1 gene. Stem Cell Res. 2017;18:1-4 pubmed publisher
    ..Q163X/p.T288NfsX3. This patient did not present mutations in the PM22, MPZ or GJB genes...
  80. Mittendorf E, Chavez MacGregor M, Vila J, Yi M, Lichtensztajn D, Clarke C, et al. Bioscore: A Staging System for Breast Cancer Patients that Reflects the Prognostic Significance of Underlying Tumor Biology. Ann Surg Oncol. 2017;24:3502-3509 pubmed publisher
    ..factors in the American Joint Committee on Cancer (AJCC) pathologic stage (PS) to assess disease-specific survival (DSS)...
  81. Zhou Q, Yao F, Han X, Li H, Yang L, Sui R. Rep1 copy number variation is an important genetic cause of choroideremia in Chinese patients. Exp Eye Res. 2017;164:64-73 pubmed publisher
    Choroidermia (CHM) is an X-linked chorioretinal disorder caused by mutations in the Rab Escort Protein 1 (Rep-1) gene...
  82. Bergamo P, Cocca E, Monaco A, Cozzolino V, Boscaino F, Ferrandino I, et al. Protective effect of Rumenic acid rich cow's milk against colitis is associated with the activation of Nrf2 pathway in a murine model. Prostaglandins Leukot Essent Fatty Acids. 2017;125:14-23 pubmed publisher
    ..St) or cow milk naturally-enriched in RA (En) to activate Nrf2 pathway and its impact on dextran sodium sulfate (DSS)-induced colitis was comparatively evaluated...
  83. Hammood A, Noor A, Alkhafagy M. Evaluation of corrosion behavior in artificial saliva of 2507 and 2205 duplex stainless steel for orthodontic wires before and after heat treatment. J Mater Sci Mater Med. 2017;28:187 pubmed publisher
    The present study investigates comparison between corrosion behavior of 2507 and 2205 DSS in artificial saliva for orthodontic wires...
  84. Gao Q, Zhao J, Fan Z, Bao J, Sun D, Li H, et al. Cardioprotective Effect of Danshensu against Ischemic/Reperfusion Injury via c-Subunit of ATP Synthase Inhibition. Evid Based Complement Alternat Med. 2017;2017:7986184 pubmed publisher
    ..It is reported that c-subunit of ATP synthase is the core component of MPTP. Danshensu (DSS), a monomer isolated from the traditional Chinese herb Danshen, has showed cardioprotective effect against IR ..
  85. Dou W, Mukherjee S, Li H, Venkatesh M, Wang H, Kortagere S, et al. Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis. PLoS ONE. 2012;7:e36075 pubmed publisher
    ..While both flavonoids abrogate dextran sodium sulfate (DSS)-mediated colon inflammation in vivo, oral delivery of a potent bacterial ?-glucuronidase inhibitor eliminates ..
  86. Zhang Y, Wu J, Weng L, Li X, Yu L, Xu Y. Valproic acid protects against MPP+-mediated neurotoxicity in SH-SY5Y Cells through autophagy. Neurosci Lett. 2017;638:60-68 pubmed publisher
    ..We found that VPA treatment counteracted MPP+-caused autophagic flux impairment...
  87. Saraya T, Watanabe T, Tsukahara Y, Ohkuma K, Ishii H, Kimura H, et al. The Correlation between Chest X-ray Scores and the Clinical Findings in Children and Adults with Mycoplasma pneumoniae Pneumonia. Intern Med. 2017;56:2845-2849 pubmed publisher
    ..To compare the radiological and laboratory data of children and adults with Mycoplasma pneumoniae pneumonia (MPP) and to evaluate the correlation between the total affected lung area and the clinical findings...
  88. Lin X, Wang L, Wang F. Chondromodulin?I suppresses tumorigenesis of human osteosarcoma cells. Mol Med Rep. 2017;16:8542-8548 pubmed publisher
    ..Chondromodulin?I (ChM-I) is a 25 kDa glycoprotein that is expressed mainly in cartilage...
  89. Yang L, Sun H, Zhao Y, Chen M, Zhang N, Jin W. Clinicopathological characteristics and survival outcomes in pleomorphic lobular breast carcinoma of the breast: a SEER population-based study. Cancer Med. 2017;: pubmed publisher
    ..In univariate analysis, PLC patients showed a worse disease-specific survival (DSS) than that of IDC patients (hazard ratio = 0.691, 95% confidence interval 0.534-0.893, P < 0.01)...
  90. Ochoa Callejero L, García Sanmartín J, Martínez Herrero S, Rubio Mediavilla S, Narro Íñiguez J, Martinez A. Small molecules related to adrenomedullin reduce tumor burden in a mouse model of colitis-associated colon cancer. Sci Rep. 2017;7:17488 pubmed publisher
    ..For each SM, four experimental groups of male mice were used: (i) Control group; (ii) SM group; (iii) DSS group (injected with azoxymethane [AOM] and drank dextran sulfate sodium [DSS]); and (iv) DSS?+?SM group (treated ..
  91. Nelis E, Timmerman V, De Jonghe P, Vandenberghe A, Pham Dinh D, Dautigny A, et al. Rapid screening of myelin genes in CMT1 patients by SSCP analysis: identification of new mutations and polymorphisms in the P0 gene. Hum Genet. 1994;94:653-7 pubmed
    ..In other families mutations have been identified in the major peripheral myelin protein P0 gene localized on chromosome 1q21-q23 (CMT1B)...
  92. Blanquet Grossard F, Pham Dinh D, Dautigny A, Latour P, Bonnebouche C, Corbillon E, et al. Charcot-Marie-Tooth type 1B neuropathy: third mutation of serine 63 codon in the major peripheral myelin glycoprotein PO gene. Clin Genet. 1995;48:281-3 pubmed
    ..This is the third mutation reported at this codon, the two previously described leading to CMT1B (serine 63 deletion), or to Dejerine-Sottas disease (cysteine for serine 63 substitution), suggesting that ..