Gene Symbol: MPZ
Description: myelin protein zero
Alias: CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, myelin protein P0, Charcot-Marie-Tooth neuropathy 1B, myelin peripheral protein
Species: human

Top Publications

  1. ncbi Prognostic factors in patients with carcinoma of the uterine cervix treated with external beam irradiation and IR-192 high-dose-rate brachytherapy
    K S Kapp
    Department of Radiology, Karl Franzens University Medical School, Graz, Austria
    Int J Radiat Oncol Biol Phys 42:531-40. 1998
  2. pmc The first major outbreak of dengue hemorrhagic fever in Delhi, India
    L Dar
    All India Institute of Medical Sciences, Ansari Nagar, New Delhi
    Emerg Infect Dis 5:589-90. 1999
  3. ncbi Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters
    F Martel
    Department of Biochemistry, Faculty of Medicine, Porto, Portugal
    Naunyn Schmiedebergs Arch Pharmacol 363:40-9. 2001
  4. ncbi Estrogen and angiotensin II interactions determine cardio-renal damage in Dahl salt-sensitive rats with heart failure
    Rie Hoshi-Fukushima
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Am J Nephrol 28:413-23. 2008
  5. ncbi Proteus mirabilis sp. intestinal microflora grow in a dextran sulfate sodium-rich environment
    Yoshio Araki
    Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Int J Mol Med 25:203-8. 2010
  6. ncbi Phenotypic clustering in MPZ mutations
    Michael E Shy
    Department of Neurology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Brain 127:371-84. 2004
  7. ncbi Peripheral neuropathies caused by mutations in the myelin protein zero
    Michael E Shy
    Wayne State University, Department of Neurology, 421 Ea Canfield, Elliman Bldg 3206, Detroit, MI 48201, USA
    J Neurol Sci 242:55-66. 2006
  8. pmc Myelin protein zero gene mutated in Charcot-Marie-tooth type 1B patients
    Y Su
    Department of Obstetrics, University of California, San Francisco 94143
    Proc Natl Acad Sci U S A 90:10856-60. 1993
  9. ncbi Charcot-Marie-Tooth neuropathy type 1B is associated with mutations of the myelin P0 gene
    K Hayasaka
    Department of Pediatrics, Akita University School of Medicine, Japan
    Nat Genet 5:31-4. 1993
  10. ncbi Myelin protein zero (MPZ) gene mutations in nonduplication type 1 Charcot-Marie-Tooth disease
    B B Roa
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Hum Mutat 7:36-45. 1996

Research Grants

  1. Metabolism and Carcinogenicity of Heterocyclic Amines
    TERRY ZENSER; Fiscal Year: 2007
  2. Early and Late Onset CMT1B
    Michael E Shy; Fiscal Year: 2010
  3. Vincent W Yang; Fiscal Year: 2016
  4. Lori A Coburn; Fiscal Year: 2016
  5. Keith T Wilson; Fiscal Year: 2016
  6. Yatrik M Shah; Fiscal Year: 2016
  7. A novel agent suppresses colitis and colon cancer
    Nengtai Ouyang; Fiscal Year: 2013
  8. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
  9. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
  10. Dezheng Zhao; Fiscal Year: 2016

Detail Information

Publications668 found, 100 shown here

  1. ncbi Prognostic factors in patients with carcinoma of the uterine cervix treated with external beam irradiation and IR-192 high-dose-rate brachytherapy
    K S Kapp
    Department of Radiology, Karl Franzens University Medical School, Graz, Austria
    Int J Radiat Oncol Biol Phys 42:531-40. 1998
    ..This study investigates pretreatment and treatment factors for their correlation with treatment outcome after EBR and HDR-ICP...
  2. pmc The first major outbreak of dengue hemorrhagic fever in Delhi, India
    L Dar
    All India Institute of Medical Sciences, Ansari Nagar, New Delhi
    Emerg Infect Dis 5:589-90. 1999
    India An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHS/DSS) occurred in 1996 in India in and near Delhi...
  3. ncbi Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters
    F Martel
    Department of Biochemistry, Faculty of Medicine, Porto, Portugal
    Naunyn Schmiedebergs Arch Pharmacol 363:40-9. 2001
    ..Uptake of [3H]MPP+ by Caco-2 and 293hEMT cells showed pH-dependence: it was significantly reduced (to 86% and 62% of control, ..
  4. ncbi Estrogen and angiotensin II interactions determine cardio-renal damage in Dahl salt-sensitive rats with heart failure
    Rie Hoshi-Fukushima
    Department of Nephrology, Saitama Medical University, Saitama, Japan
    Am J Nephrol 28:413-23. 2008
    ..The present study attempted to elucidate the relationship between the process of cardiac remodeling and nephrosclerosis in ovariectomized Dahl salt-sensitive (DSS) rats with myocardial infarction (MI).
  5. ncbi Proteus mirabilis sp. intestinal microflora grow in a dextran sulfate sodium-rich environment
    Yoshio Araki
    Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Int J Mol Med 25:203-8. 2010
    ..As an animal model, the oral administration of dextran sulfate sodium (DSS) induces colitis, which exhibits several clinical and histological features similar to UC...
  6. ncbi Phenotypic clustering in MPZ mutations
    Michael E Shy
    Department of Neurology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Brain 127:371-84. 2004
    ..MPZ mutations in humans cause the inherited demyelinating neuropathy CMT1B. Some mutations cause the severe neuropathies of infancy designated as Dejerine-Sottas disease, while others cause ..
  7. ncbi Peripheral neuropathies caused by mutations in the myelin protein zero
    Michael E Shy
    Wayne State University, Department of Neurology, 421 Ea Canfield, Elliman Bldg 3206, Detroit, MI 48201, USA
    J Neurol Sci 242:55-66. 2006
    Charcot-Marie-Tooth disease type 1B (CMT1B) is caused by mutations in the major PNS myelin protein myelin protein zero (MPZ)...
  8. pmc Myelin protein zero gene mutated in Charcot-Marie-tooth type 1B patients
    Y Su
    Department of Obstetrics, University of California, San Francisco 94143
    Proc Natl Acad Sci U S A 90:10856-60. 1993
    Autosomal dominant of Charcot-Marie-Tooth disease (CMT), whose gene is type 1B (CMT1B), has slow nerve conduction with demyelinated Schwann cells...
  9. ncbi Charcot-Marie-Tooth neuropathy type 1B is associated with mutations of the myelin P0 gene
    K Hayasaka
    Department of Pediatrics, Akita University School of Medicine, Japan
    Nat Genet 5:31-4. 1993
    ..molecule and maps to chromosome 1q22-q23, in the region of the locus for Charcot-Marie-Tooth neuropathy type 1B (CMT1B)...
  10. ncbi Myelin protein zero (MPZ) gene mutations in nonduplication type 1 Charcot-Marie-Tooth disease
    B B Roa
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Hum Mutat 7:36-45. 1996 the MPZ gene are associated with the demyelinating peripheral neuropathies Charcot-Marie-Tooth disease type 1B (CMT1B), and the more severe Dejerine-Sottas syndrome (DSS)...
  11. ncbi Clinical phenotypes of different MPZ (P0) mutations may include Charcot-Marie-Tooth type 1B, Dejerine-Sottas, and congenital hypomyelination
    L E Warner
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 17:451-60. 1996 (MPZ) gene, encoding the major structural protein (P0) of peripheral nerve myelin, in patients with either CMT1B, DSS, or CH...
  12. ncbi Mutations in the peripheral myelin genes and associated genes in inherited peripheral neuropathies
    E Nelis
    Flanders Interuniversity Institute for Biotechnology VIB, Born Bunge Foundation, University of Antwerp, Department of Biochemistry, Belgium
    Hum Mutat 13:11-28. 1999
    ..e., Charcot-Marie-Tooth disease type 1 (CMT1) and type 2 (CMT2), Dejerine-Sottas syndrome (DSS), hereditary neuropathy with liability to pressure palsies (HNPP),..
  13. doi Unusual Charcot-Marie-Tooth phenotype due to a mutation within the intracellular domain of myelin protein zero
    Christiane Schneider-Gold
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Muscle Nerve 41:550-4. 2010
    Myelin protein zero (MPZ/P0) constitutes a major component of compact peripheral myelin. We report a family with a missense mutation, c.700G>T p.Asp234Tyr (deviant nomenclature: c.670G>T, p...
  14. doi Different cellular and molecular mechanisms for early and late-onset myelin protein zero mutations
    Marina Grandis
    Department of Neurosciences, Ophthalmology and Genetics, Universityof Genova, 16132 Genova, Italy
    Hum Mol Genet 17:1877-89. 2008
    ..encoding myelin protein zero (MPZ), cause inherited neuropathies collectively called Charcot-Marie-Tooth type 1B (CMT1B)...
  15. ncbi Myelin P0 glycoprotein: identification of the site phosphorylated in vitro and in vivo by endogenous protein kinases
    S Hilmi
    Institut de Biochimie Génétique et Cellulaire du CNRS, Bordeaux, France
    J Neurochem 64:902-7. 1995
    ..Our results strongly suggest that the phosphorylation of these serine residues alters the secondary structure of this domain. Such a structural perturbation could play an important role in myelin compaction at the dense line level...
  16. ncbi [A sporadic case of Charcot-Marie-Tooth disease type 1 A associated with a duplication in chromosome 17 p11.2-p12]
    M Inoue
    Department of Pediatrics, Yamada Red Cross Hospital, Mie
    No To Hattatsu 31:452-7. 1999
    ..Sporadic cases of autosomal dominant-CMT type 1 can not be clinically differentiated from recessive-CMT1. Testing for the CMT1A duplication is an important first step even in the molecular diagnosis of sporadic CMT1.
  17. doi Cellular characterization of MPZ mutations presenting with diverse clinical phenotypes
    Yi Chung Lee
    Department of Neurology, National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Neurol 257:1661-8. 2010
    ..The aim of this study was to characterize the cellular manifestations of various MPZ mutations associated with CMT1, Dejerine-Sottas syndrome (DSS) and CMT2, and to correlate their cellular and clinical phenotypes...
  18. ncbi A novel type of hereditary motor and sensory neuropathy characterized by a mild phenotype
    P De Jonghe
    Department of Biochemistry, University Hospital Antwerp, Belgium
    Arch Neurol 56:1283-8. 1999
    ..2 (CMT1A), 1q21-q23 (CMT1B), and 10q21.1-q22.1 (designated here as CMT1D)...
  19. ncbi Myelin protein zero: mutations in the cytoplasmic domain interfere with its cellular trafficking
    Viren Konde
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA
    J Neurosci Res 83:957-64. 2006
    The cytoplasmic domain of myelin protein zero (MPZ), the principal protein of peripheral myelin, undergoes phosphorylation on several serine residues and a tyrosine group that is maximal during peak nerve myelination...
  20. pmc Induction of myelin protein zero by early growth response 2 through upstream and intragenic elements
    Sung Wook Jang
    Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 284:20111-20. 2009
    The Mpz (myelin protein zero) gene codes for the principal component of myelin in the peripheral nervous system, and mutations in this gene cause human peripheral myelinopathies...
  21. ncbi The gene responsible for adrenal hypoplasia congenita, DAX-1, encodes a nuclear hormone receptor that defines a new class within the superfamily
    T P Burris
    Department of Pediatrics, UCLA School of Medicine 90024, USA
    Recent Prog Horm Res 51:241-59; discussion 259-60. 1996
    ..cloning methods and has been named DAX-1 based on its localization within the dosage-sensitive sex reversal (DSS) locus and the AHC locus on the X chromosome. The DAX-1 gene consists of two exons separated by a 3.4 kb intron...
  22. ncbi PMP22 Thr118Met is not a clinically relevant CMT1 marker
    P Young
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich
    J Neurol 247:696-700. 2000
    ..or, since hemizygosity for this variant has been found in two patients with Charcot-Marie-Tooth disease type 1 (CMT1 patients), it can act as a recessive CMT1 mutation...
  23. ncbi Immunolocalization and quantitation of transforming growth factor alpha in hydatidiform mole
    J Molykutty
    Regional Cancer Centre, Medical College P.O, Trivandrum, Kerala, India
    Tumori 85:183-7. 1999
    Complete hydatidiform mole (CHM), a condition related to abnormal gestation, occurs predominantly in the young reproductive age group and has a high prevalence rate in the Trivandrum region, occurring in 1.2% of deliveries...
  24. ncbi Aberrant crypt foci in the colonic mucosa of rats treated with a genotoxic and nongenotoxic colon carcinogen
    L O Whiteley
    Procter and Gamble, Cincinnati, Ohio 45253, USA
    Toxicol Pathol 24:681-9. 1996
    ..Six-wk-old Fischer-344 rats were administered dextran sulfate (DSS, nongenotoxin) in the drinking water or azoxymethane (AOM, genotoxin) by single subcutaneous injection...
  25. pmc Immunomodulation in the treatment of multiple sclerosis and amyotrophic lateral sclerosis: a model for autoimmune disorders
    K Alonso
    Institute for Advanced Studies in Medicine, Atlanta, Georgia, USA
    J Natl Med Assoc 87:561-8. 1995
    ..therapy (average treatment duration: 3 years) with performance status 3-4 (mean Disability Status Scale [DSS]: 82) who demonstrated circulating lymphokine inhibitor factors were selected for a monthly immunomodulatory ..
  26. pmc Inhibition by dizocilpine (MK-801) of striatal dopamine release induced by MPTP and MPP+: possible action at the dopamine transporter
    P B Clarke
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    Br J Pharmacol 114:315-22. 1995
    ..MPTP) and its principal metabolite, the 1-methyl-4-phenylpyridinium ion (MPP+)...
  27. ncbi Regulation of myelin-specific gene expression. Relevance to CMT1
    J Kamholz
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ann N Y Acad Sci 883:91-108. 1999
    ..Point mutlations in the genes encoding the myelin proteins PMP22 and P0 cause CMT1A without a gene duplication and CMT1B, respectively...
  28. pmc Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease
    X G Xia
    Neurodegeneration Laboratory, Department of Neurology and Medical School, , Hoppe-Seyler Strasse 3, , Germany
    Proc Natl Acad Sci U S A 98:10433-8. 2001
    ..only partial protection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/1-methyl-4-phenylpyridinium (MPTP/MPP(+)) model of Parkinson's disease, we investigated the role of the proapoptotic c-Jun N-terminal kinase (JNK) ..
  29. ncbi Development and characteristics of a new strain of obese hyperinsulinemic and hyperlipidemic Dahl salt-sensitive rat. The Dahl salt-sensitive/NIH-corpulent rat
    O E Michaelis
    Beltsville Human Nutrition Research Center, ARS, USDA, MD 20705, USA
    Am J Hypertens 8:467-73. 1995
    A new congenic rat strain, the Dahl salt-sensitive/NIH-corpulent (DSS/N-cp) rat, has been developed to study the role of obesity and type of dietary carbohydrate in the development of hypertension and its complications...
  30. ncbi Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems
    F Martel
    Department of Biochemistry, Faculty of Medicine, Porto, Portugal
    Naunyn Schmiedebergs Arch Pharmacol 364:487-95. 2001
    ..The characteristics of hEMT-mediated uptake of [3H]1-methyl-4-phenylpyridinium ([3H]MPP+) were studied by incubating the cells at 37 degrees C for 1 min with 200 nM [3H]MPP+...
  31. ncbi The efficacy of a combination of ondansetron, methylprednisolone and metopimazine in patients previously uncontrolled with a dual antiemetic treatment in cisplatin-based chemotherapy. The French Ondansetron Study Group
    B Lebeau
    Hopital Saint Antoine, Paris, France
    Ann Oncol 8:887-92. 1997
    ..double-blind, multicentre, parallel group study was to examine the benefit of the addition of metopimazine (MPZ), a dopamine receptor antagonist, to the combination of ondansetron + methylprednisolone (O + M) in the prevention ..
  32. ncbi Practice patterns for prostate cancer in nine central and northern Italy radiation oncology centers: a survey including 1759 patients treated during two decades (1980-1998)
    Stefano Maria Magrini
    Department of Radiation Oncology, Istituto del Radio, O Alberti Brescia University, Brescia, Italy
    Int J Radiat Oncol Biol Phys 52:1310-9. 2002
  33. ncbi Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration
    K S McNaught
    Neurodegenerative Diseases Research Centre, King s College, London, U K
    Biochem Pharmacol 51:1503-11. 1996
    Isoquinoline derivatives exert 1-methyl-4-phenylpyridinium (MPP+)-like activity as inhibitors of complex I and alpha-ketoglutarate dehydrogenase activity in rat brain mitochondrial fragments...
  34. ncbi Mechanisms of toxicity and cellular resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium in adrenomedullary chromaffin cell cultures
    J F Reinhard
    Division of Medicinal Biochemistry, Burroughs Wellcome Co, Research Triangle Park, North Carolina 27709
    J Neurochem 55:311-20. 1990
    ..catecholamine neuron toxicants 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+)...
  35. ncbi Role of cartilage-derived anti-angiogenic factor, chondromodulin-I, during endochondral bone formation
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Osteoarthritis Cartilage 9:S91-101. 2001
    ..We previously identified a cartilage-specific 25 kDa glycosylated protein, chondromodulin-I (ChM-I), as anti-angiogenic factor...
  36. pmc Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    BMC Cancer 7:84. 2007
  37. ncbi Activation of toll-like receptor 3 protects against DSS-induced acute colitis
    Matam Vijay-Kumar
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Inflamm Bowel Dis 13:856-64. 2007
  38. ncbi Sex determining gene on the X chromosome short arm: dosage sensitive sex reversal
    T Ogata
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Acta Paediatr Jpn 38:390-8. 1996
    The present review article summarizes current knowledge concerning the sex determining gene on Xp21, termed DSS (dosage sensitive sex reversal)...
  39. ncbi Differential effects of L-deprenyl on MPP+- and MPTP-induced dopamine overflow in microdialysates of striatum and nucleus accumbens
    W R Wu
    Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Life Sci 67:241-50. 2000
    The present studies investigated the effects of L-deprenyl, 1-methyl-4-phenylpyridinium ion (MPP+) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the efflux of dopamine and its metabolites in microdialysates of striatum and ..
  40. ncbi The parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) mediates release of l-3,4-dihydroxyphenylalanine (l-DOPA) and inhibition of l-DOPA decarboxylase in the rat striatum: a microdialysis study
    Steven B Foster
    Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019 0370, USA
    Chem Res Toxicol 16:1372-84. 2003
    ..have been implicated as key participants in the dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium (MPP(+))...
  41. ncbi Effect of desferrioxamine, a strong iron (III) chelator, on 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in the rat striatum
    Toshio Obata
    Department of Analytical Chemistry, Ohu University School of Pharmaceutical Sciences, Koriyama, Fukushima 963 8611, Japan
    Eur J Pharmacol 539:34-8. 2006
    ..was examined that the desferrioxamine, a strong iron (III) chelator, enhanced 1 methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) generation in the extracellular fluid of caudate nucleus anesthetized rats...
  42. ncbi Uptake of (3)H-1-methyl-4-phenylpyridinium ((3)H-MPP(+)) by human intestinal Caco-2 cells is regulated by phosphorylation/dephosphorylation mechanisms
    Fatima Martel
    Department of Biochemistry, Faculty of Medicine, 4200 319 Porto, Portugal
    Biochem Pharmacol 63:1565-73. 2002
    ..The intestinal apical uptake of 1-methyl-4-phenylpyridinium (MPP(+)) was studied by incubating Caco-2 cells at 37 degrees for 5 min with 200 nM (3)H-MPP(+)...
  43. ncbi Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation
    H S Cooper
    Department of Pathology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Carcinogenesis 21:757-68. 2000
    ..the histopathology and inflammation scores as they relate to dysplasia and cancer in the dextran sulfate sodium (DSS) colitis model...
  44. pmc Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome
    Thi Phuong Lan Nguyen
    Department of Immunogenetics, Institute of Tropical Medicine NEKKEN, Nagasaki University, Japan
    PLoS Negl Trop Dis 2:e304. 2008
    ..Recently, the severe forms, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading cause of death among children in Southern Vietnam...
  45. ncbi Reserpine prevents hydroxyl radical formation by MPP+ in rat striatum
    T Obata
    Department of Pharmacology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Brain Res 828:68-73. 1999
    ..The present study investigated the blockage of dopamine (DA) oxidation by reserpine. 1-Methyl-4 phenylpyridinium ion (MPP+) increased the release of DA and the formation of hydroxyl radical ( r22. OH). The r22...
  46. doi Alternate hypothesis on the pathogenesis of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) in dengue virus infection
    Sansanee Noisakran
    Medical Biotechnology Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani, 12120, Thailand
    Exp Biol Med (Maywood) 233:401-8. 2008
    ..are 200,000 to 500,000 cases of potential life-threatening dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS), characterized by thrombocytopenia and increased vascular permeability...
  47. doi Sensitive and selective liquid chromatography/tandem mass spectrometry methods for quantitative analysis of 1-methyl-4-phenyl pyridinium (MPP+) in mouse striatal tissue
    Mei Yi Zhang
    Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 874:51-6. 2008
    ..Determining the brain concentrations of 1-methyl-4-phenyl pyridium (MPP+), the neurotoxic metabolite of MPTP, is critical for evaluating drugs designed to potentially treat PD...
  48. ncbi High sucrose diets increase blood pressure of both salt-sensitive and salt-resistant rats
    H G Preuss
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20007
    Am J Hypertens 5:585-91. 1992
    ..Dahl salt-sensitive (DSS) and salt-resistant (DSR) rats were fed one of two low salt diets containing either high sugar (sucrose 51...
  49. ncbi Evidence for hydroxyl radical scavenging action of nitric oxide donors in the protection against 1-methyl-4-phenylpyridinium-induced neurotoxicity in rats
    Rebecca Banerjee
    Division of Cell Biology and Physiology, Laboratory of Clinical and Experimental Neuroscience, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700 032, India
    Neurochem Res 33:985-95. 2008 the nigrostriatal dopaminergic neurotoxicity caused by the parkinsonian neurotoxin, 1-methyl-4-phenylpyridinium (MPP+)...
  50. pmc Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrode
    G P Davey
    Department of Biochemistry, Trinity College, Dublin, Ireland
    Biochem J 288:439-43. 1992
    ..The toxicity of MPTP is believed to be due to its metabolite 1-methyl-4-phenylpyridinium (MPP+)...
  51. ncbi Natural history of human T-lymphotropic virus 1-associated myelopathy: a 14-year follow-up study
    Stephane Olindo
    Department of Neurology, University Hospital of Fort de France, Fort de France, Martinique
    Arch Neurol 63:1560-6. 2006
    ..The progression of neurological disability in human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) remains undefined...
  52. ncbi Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis
    M Mahler
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Am J Physiol 274:G544-51. 1998
    Dextran sulfate sodium (DSS)-induced murine colitis represents an experimental model for human inflammatory bowel disease...
  53. ncbi Combined effect of dopamine and MPP+ on membrane permeability in mitochondria and cell viability in PC12 cells
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, 156 756, Seoul, South Korea
    Neurochem Int 43:147-54. 2003
    The present study examined the combined effect of dopamine and 1-methyl-4-phenylpyridinium (MPP(+)) on the membrane permeability in isolated brain mitochondria and on cell viability in PC12 cells...
  54. ncbi Improving the quality of randomized controlled trials in Chinese herbal medicine, part II: control group design
    Zhao Xiang Bian
    School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China
    Zhong Xi Yi Jie He Xue Bao 4:130-6. 2006
    To discuss the types of control groups in randomized controlled trials (RCTs) of Chinese herbal medicine (CHM), and to provide suggestions for improving the design of control group in future clinical studies in this therapeutic area.
  55. ncbi Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter
    Alexander Storch
    Department of Neurology, University of Ulm Medical School, Oberer Eselsberg 45, 89081, Ulm, Germany
    Biochem Pharmacol 63:909-20. 2002
    ..neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its active metabolite 1-methyl-4-phenylpyridine (MPP(+)) may contribute to dopaminergic neurodegeneration in Parkinson's disease...
  56. ncbi Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice
    Yuji Naito
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 18:560-9. 2003
    ..To further define the role of TNF-alpha in intestinal inflammation, we studied the effects of dextran sulfate sodium (DSS) administration in mice with targeted deletions of TNF-alpha gene.
  57. doi Calpain plays a central role in 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in cerebellar granule neurons
    Richard A Harbison
    Department of Biological Sciences and Eleanor Roosevelt Institute, University of Denver, Seeley G Mudd Science Bldg, 2101 E Wesley Ave, Denver, CO 80208, USA
    Neurotox Res 19:374-88. 2011
    1-Methyl-4-phenylpyridinium (MPP(+))-induced neurotoxicity has previously been attributed to either caspase-dependent apoptosis or caspase-independent cell death...
  58. ncbi Comparison of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) effects on mouse heart norepinephrine
    R W Fuller
    Lilly Research Laboratories, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, IN 46285
    Biochem Pharmacol 37:3343-7. 1988
    b>MPP+ (1-methyl-4-phenylpyridinium) mimicked MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in producing marked, dose-related depletion of cardiac norepinephrine after a single oral or subcutaneous dose in mice...
  59. doi Cooperation and competition between lateral and medial perforant path synapses in the dentate gyrus
    Hatsuo Hayashi
    Department of Brain Science and Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Hibikino 2 4, Wakamatsu ku, Kitakyushu 808 0196, Japan
    Neural Netw 24:233-46. 2011 the dentate gyrus from entorhinal cortex layer II through the lateral and medial perforant paths (LPP and MPP), which establish synapses on granule cell dendrites in the outer and middle one-thirds of the dentate molecular ..
  60. ncbi The effect of glia-conditioned medium on dopamine neurons in culture. Modulation of apoptosis, tyrosine hydroxylase expression and 1-methyl-4-phenylpyridinium toxicity
    M A Mena
    Departamento de Investigacion, Hospital Ramon y Cajal, and Madrid, Spain
    J Neural Transm (Vienna) 106:1105-23. 1999
    ..of apoptotic cells in midbrain neuronal cultures, before and after exposure to 1-methyl-4-phenylpyridinium (MPP+). Fetal midbrain neuronal cultures were treated with vehicle, MPP+, 10(-5) M, mesencephalic GCM, or MPP+ plus GCM...
  61. pmc Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis
    Satheesh K Sainathan
    Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA
    Inflamm Bowel Dis 14:88-99. 2008
    ..To study the mechanism, we examined the effects of GM-CSF in the dextran sulfate sodium (DSS)-induced acute colitis model. We hypothesized that GM-CSF may work through effects on dendritic cells (DCs).
  62. doi Assessment of the role of histopathology and DNA image analysis in the diagnosis of molar and non-molar abortion: a study of 89 cases in the center of Tunisia
    Hanene Landolsi
    Department of Histopathology Cytopathology, Division of Pathology, Faculty of Medicine, Farhat Hached University Hospital, Sousse, Republic of Tunisia
    Pathol Res Pract 205:789-96. 2009
    ..We retrospectively studied 89 specimens of abortus conception, including 35 complete hydatidiform moles (CHM), 12 partial hydatidiform moles (PHM), and 42 hydropic abortions (HA)...
  63. ncbi Distinct epithelial responses in experimental colitis: implications for ion uptake and mucosal protection
    Ingrid B Renes
    Laboratory of Pediatrics, Pediatric Gastroenterology and Nutrition, Erasmus Medical Center, Rotterdam, and Sophia Children s Hospital, Rotterdam 3015GE, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 283:G169-79. 2002
    ..goblet cell-specific functions during the different phases of acute colitis induced with dextran sulfate sodium (DSS). Rats were treated with DSS for 7 days, followed by a 7-day recovery period...
  64. ncbi Short-term exposure to somatostatin or muscarinic agonists reduce acetylcholine-induced 3H-MPP+ release from bovine adrenal medullary cells
    Laura Ribeiro
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319, Porto, Portugal
    J Biomed Sci 14:347-55. 2007
    ..SSTR) selective agonists as well as muscarinic receptors agonists upon acetylcholine-induced release of (3)H-MPP(+ )from bovine adrenal medullary cells...
  65. pmc Variable toxicological response to the loss of OXPHOS through 1-methyl-4-phenylpyridinium-induced mitochondrial damage and anoxia in diverse neural immortal cell lines
    Elizabeth A Mazzio
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Dyson Building Room 104, Tallahassee, FL 32307, USA
    Cell Biol Toxicol 26:527-39. 2010
    ..utilization patterns which in turn may affect LC(50) for the mitochondrial toxin 1-methyl-4-phenylpyridinium (MPP(+)) in various cell lines...
  66. ncbi L-carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain culture
    C Wang
    Division of Neurotoxicology, HFT 132, National Center for Toxicological Research U S Food and Drug Administration, Jefferson, AR 72079, USA
    Neuroscience 144:46-55. 2007
    1-Methyl-4-phenylpyridinium ion (MPP+), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with an elevation of intracellular reactive oxygen ..
  67. doi The development and evaluation of a simple method of gestational age estimation
    Rachel C Allan
    Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Northern Territory, Australia
    J Paediatr Child Health 45:15-9. 2009
    The aims of this study were to develop and evaluate a shorter gestational age estimation method based on the Dubowitz scoring system (DSS) that could be taught easily to untrained health-care workers.
  68. ncbi Sphincters of canine hepatic sublobular veins respond to endothelin-1 and 3
    S Aharinejad
    First Department of Anatomy, University of Vienna, Austria
    Anat Embryol (Berl) 196:299-309. 1997
    ..In 14 dogs mean systemic (MSP) and mean portal venous pressure (MPP) were measured...
  69. ncbi Dejerine-Sottas syndrome associated with point mutation in the peripheral myelin protein 22 (PMP22) gene
    B B Roa
    Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
    Nat Genet 5:269-73. 1993
    ..Clinical symptoms are similar but more severe than Charcot-Marie-Tooth disease type 1 (CMT1), of which the major subtype, CMT1A, results either from duplication of a 1...
  70. pmc The beta subunit of the mitochondrial processing peptidase from rat liver: cloning and sequencing of a cDNA and comparison with a proposed family of metallopeptidases
    V Paces
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 90:5355-8. 1993
    ..are synthesized with amino-terminal leader peptides that are removed by the mitochondrial processing peptidase (MPP) after translocation...
  71. ncbi Ultrastructural distribution of PMP22 in Charcot-Marie-Tooth disease type 1A
    C Haney
    Department of Neurosciences, Cleveland Clinic Foundation, Ohio 44195, USA
    J Neuropathol Exp Neurol 55:290-9. 1996
    ..distribution of PMP22 and other myelin proteins in normal human peripheral nervous system (PNS) nerves and in CMT1 patients with or without the CMT1A duplication on chromosome 17...
  72. ncbi Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Kyoto University, Japan
    Biochem Biophys Res Commun 249:885-90. 1998
    Cartilage-specific functional matrix chondromodulin-I (ChM-I) is a 25 kDa glycoprotein purified from fetal bovine epiphyseal cartilage which stimulates the growth of rabbit chondrocytes and the colony formation of the cells in agarose...
  73. ncbi Echocardiographic, morphologic, and geometric variations of the left ventricular outflow tract: possible role in the pathogenesis of discrete subaortic stenosis
    H E Tutar
    Ankara University Faculty of Medicine, Department of Pediatric Cardiology, Turkey
    Angiology 51:213-21. 2000
    Although the clinical features and natural course of discrete subaortic stenosis (DSS) are well defined, the etiology remains speculative...
  74. ncbi A top down approach to protein structural studies using chemical cross-linking and Fourier transform mass spectrometry
    Gary H Kruppa
    Sandia National Laboratories, Livermore, CA 94551 0969, USA
    Rapid Commun Mass Spectrom 17:155-62. 2003
    ..that reaction of ubiquitin with the homobifunctional lysine-lysine cross-linking reagent dissuccinimidyl suberate (DSS) resulted in two cross-links consistent with the known ubiquitin tertiary structure (K6-K11 and K48-K63)...
  75. ncbi Screening of the early growth response 2 gene in Japanese patients with Charcot-Marie-Tooth disease type 1
    Chikahiko Numakura
    Department of Pediatrics, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    J Neurol Sci 210:61-4. 2003
    Charcot-Marie-Tooth disease type 1 (CMT1) is a heterogeneous disorder. Most CMT1 patients are associated with a duplication of 17p11...
  76. ncbi Anionic microparticles are a potent delivery system for recombinant antigens from Neisseria meningitidis serotype B
    Manmohan Singh
    Chiron Vaccines Research, Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608, USA
    J Pharm Sci 93:273-82. 2004 a w/o/w solvent evaporation process in the presence of the anionic surfactant dioctyl sodium sulfosuccinate (DSS)...
  77. pmc Can clinical trials requiring frequent participant contact be conducted over the Internet? Results from an online randomized controlled trial evaluating a topical ointment for herpes labialis
    Margaret Formica
    Division of Rheumatology, Tufts New England Medical Center, Box 406, 750 Washington Street, Boston, MA 02111, USA
    J Med Internet Res 6:e6. 2004
    ..An Internet-based randomized clinical trial design may reduce this burden, permitting frequent symptom reports with considerably less effort...
  78. ncbi Prognostic value of trophoblastic proliferation in complete hydatidiform moles in predicting persistent disease
    L C Horn
    Institute of Pathology, Division of Perinatal and Gynecologic Pathology, Leipzig University, Liebigstrasse 26, Leipzig D 04103, Germany
    Pathol Res Pract 202:151-6. 2006
    The clinical outcome of patients with complete hydatidiform moles (CHM) is variable. The correlation between trophoblastic proliferation and development of persistent disease was evaluated...
  79. doi Creation of a digital slide and tissue microarray resource from a multi-institutional predictive toxicology study in the rat: an initial report from the PredTox group
    Laoighse Mulrane
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Exp Toxicol Pathol 60:235-45. 2008
    ..In respect to assessment of the digital slides, a web-enabled digital slide management system, Digital SlideServer (DSS), was employed to enable integration of the digital slide content into the 'omics database and to facilitate remote ..
  80. doi Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease
    Mariya Moosajee
    Department of Clinical Neuroscience, Imperial College London, London SW7 2AZ, UK
    Hum Mol Genet 17:3987-4000. 2008
    ..nonsense mutations and partially restore full-length, functional protein in a zebrafish model of choroideraemia (chm(ru848); juvenile chorio-retinal degeneration) and in two models of ocular coloboma (noi(tu29a) and gup(m189); ..
  81. pmc Systematic review of Chinese herbal medicine for functional constipation
    Chung Wah Cheng
    School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
    World J Gastroenterol 15:4886-95. 2009
    ..Although there are many Chinese herbal medicine (CHM) interventions available, and some have been verified by clinical trials, their efficacy and safety are still ..
  82. doi Attenuation of experimental murine colitis by acanthoic acid from Acanthopanax koreanum
    Ok Hwa Kang
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang Oriental Medicines Research Institute, Iksan 570 749, Korea
    Arch Pharm Res 33:87-93. 2010
    ..We examined the effect of AA in dextran sulfate sodium (DSS)-induced colitis. AA (100 mg/kg or 300 mg/kg) was administered p.o. daily for 7 days...
  83. pmc Puberty is delayed in male mice with dextran sodium sulfate colitis out of proportion to changes in food intake, body weight, and serum levels of leptin
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Pediatr Res 69:34-9. 2011
    ..We induced colitis in 32-d-old male mice using dextran sodium sulfate (DSS), resulting in 10 d of worsening colitis...
  84. doi Traits of the metabolic syndrome alter corpulent obesity in LAN, SHR and DSS rats: behavioral and metabolic interactions with adrenalectomy
    Lynda M Brown
    Department of Nutrition, University of North Carolina of Greensboro, Greensboro, NC 27402, United States
    Physiol Behav 103:98-103. 2011
    ..strains included Lister and Albany NIH (LAN) rats, Spontaneously Hypertensive Rats (SHR) and Dahl Salt Sensitive (DSS) rats that were congenically bred...
  85. pmc Exome sequencing allows for rapid gene identification in a Charcot-Marie-Tooth family
    Gladys Montenegro
    John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, FL 33136, USA
    Ann Neurol 69:464-70. 2011
    ..Genetic testing decision trees are therefore broadly based on a small number of major subtypes (eg, CMT1, CMT2) and the observed mutation frequency for CMT genes...
  86. pmc DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease
    Xinglong Wang
    Department of Pathology, Case Western Reserve University, 2103 Connell Road, Cleveland, OH 44106, USA
    Aging Cell 10:807-23. 2011 Parkinson's disease (PD) can be modeled by the administration of the neurotoxin 1-methyl-4-phenylpyridinium (MPP(+) )...
  87. pmc Mechanical property characterization of electrospun recombinant human tropoelastin for vascular graft biomaterials
    Kathryn A McKenna
    Oregon Medical Laser Center, Providence St Vincent Medical Center, Portland, OR 97225, USA
    Acta Biomater 8:225-33. 2012
    ..Disuccinimidyl suberate (DSS) was used to cross-link electrospun rTE fibers to produce a polymeric recombinant tropoelastin (prTE) matrix that ..
  88. doi Thiamine is a substrate of organic cation transporters in Caco-2 cells
    Clara Lemos
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Eur J Pharmacol 682:37-42. 2012 the thiamine structural analogues oxythiamine and amprolium, 6) inhibited by the unrelated organic cations MPP(+), clonidine, dopamine, serotonin, 7) inhibited by the OCT inhibitors decynium22 and progesterone...
  89. doi Acute appendicitis: a disease severity score for the acute care surgeon
    Geoffrey C Garst
    Department of Surgery, Denver Health Medical Center, University of Colorado Denver, Denver, Colorado, USA
    J Trauma Acute Care Surg 74:32-6. 2013
    Analogous to organ injury scales developed for trauma, a scoring system is needed for acute care surgery. The purpose of this study was to develop a disease severity score (DSS) for acute appendicitis, the most common surgical emergency.
  90. doi Effects of prednisolone on refractory mycoplasma pneumoniae pneumonia in children
    Zhengxiu Luo
    Department of Respiratory, Children s Hospital, Chong Qing Medical University, Chongqing, China
    Pediatr Pulmonol 49:377-80. 2014
    To prospectively evaluate prednisolone treatment in children with refractory Mycoplasma pneumonia pneumonia (MPP).
  91. doi Effects of ionic liquid and nanogold particles on high-performance liquid chromatography-electrochemical detection and their application in highly efficient separation and sensitive analysis of five phenolic acids in Xuebijing injection
    Pu Jia
    Key Laboratory of Resource Biology and Biotechnology in Western China, School of Life Sciences, Northwest University, Xi an, Shaanxi 710069, China
    Talanta 107:103-10. 2013
    ..on the chromatographic characteristics of five phenolic acids in Xuebijing injection, including danshensu (DSS), protocatechuic acid (PA), protocatechuic aldehyde (PAH), hydroxy safflower yellow A (HSYA) and ferulic acid (FA)...
  92. doi Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcinogenesis in mice
    Soichiro Sasaki
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology, Tokyo, Japan
    Int J Cancer 135:1297-306. 2014
    ..Combined treatment of azoxymethane (AOM) and dextran sulfate sodium (DSS) recapitulates colitis-associated cancer in mice...
  93. doi Generalized estimating equation model and long-term exposure effect of antipsychotics on SH-SY5Y cells against oxidative stressors
    Ming Chang Yang
    Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung City, Taiwan, ROC Institute of Biological Science, National Sun Yat Sen University, Kaohsiung City, Taiwan, ROC
    Eur J Pharmacol 740:697-702. 2014
    ..The hydrogen peroxide (H2O2), N-methyl-4-phenylpyridinium ion (MPP+), and β-amyloid peptide were used to treat cells with or without APDs (paliperidone, risperidone, olanzapine and ..
  94. doi Therapeutic efficacy of IL-17A antibody injection in preventing the development of colitis associated carcinogenesis in mice
    Haili Qi
    Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
    Immunobiology 220:54-9. 2015
    ..injection on the development of CAC was assessed in 1,2-dimethylhydrazine (DMH) plus dextran sulfate sodium (DSS) induced CAC mouse model...
  95. doi Methotrexate-grafted-oligochitosan micelles as drug carriers: synthesis and biological evaluations
    Ali Fattahi
    Medical Biology Research Center, Kermanshah University of Medical Sciences, 6734667149, Kermanshah, Iran
    J Mater Sci Mater Med 26:119. 2015
    ..56 mg/l. Analysis of micelles with different degree of substitutions (DSs) revealed that the size of micelles decreased by increasing DS while zeta potential was reduced...
  96. doi On the origin of EDSS
    John F Kurtzke
    Georgetown University School of Medicine, Washington, DC, USA Electronic address
    Mult Scler Relat Disord 4:95-103. 2015
    ..Systems (FS), and these provided the basis for an 11 step 0-10 rank order scale, the Disability Status Scale (DSS)...
  97. pmc Fuzheng Kang'ai decoction combined with gefitinib in advanced non-small cell lung cancer patients with epidermal growth factor receptor mutations: study protocol for a randomized controlled trial
    Xiao Bing Yang
    Department of Oncology, Guangdong Provincial Hospital of Traditional Chinese Medicine, No 111 Dade Road, Guangzhou, Guangdong, 510120, China
    Trials 16:146. 2015
    ..Chinese herbal medicine (CHM) has been used as a complementary therapy for cancer for decades in China...
  98. pmc The influence of somatosensory and muscular deficits on postural stabilization: Insights from an instrumented analysis of subjects affected by different types of Charcot-Marie-Tooth disease
    Tiziana Lencioni
    Biomedical Technology Department, IRCCS Foundation Don Gnocchi Onlus, Milan, Italy Electronic address
    Neuromuscul Disord 25:640-5. 2015
    Charcot-Marie-Tooth (CMT) disease is the most common hereditary neuromuscular disorder. CMT1 is primarily demyelinating, CMT2 is primarily axonal, and CMTX1 is characterized by both axonal and demyelinating abnormalities...
  99. doi Differential Recruitment of Dentate Gyrus Interneuron Types by Commissural Versus Perforant Pathways
    Tsan Ting Hsu
    Institute of Neuroscience
    Cereb Cortex 26:2715-27. 2016
    ..we investigated neurotransmission of the hilar commissural pathway (COM) and the medial perforant path (MPP) to the DG in acutely prepared mouse slices...
  100. doi A new pharmacological effect of levornidazole: Inhibition of NLRP3 inflammasome activation
    Xingqi Wang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093, China
    Biochem Pharmacol 97:178-88. 2015
    ..Therefore, we used the widely applied NLRP3 inflammasome-related models of dextran sodium sulfate (DSS)-induced colitis and LPS-induced endotoxin shock to confirm the novel pharmacological effect of levornidazole in ..
  101. pmc Genotype-phenotype characteristics and baseline natural history of heritable neuropathies caused by mutations in the MPZ gene
    Oranee Sanmaneechai
    1 Department of Neurology, University of Iowa Hospitals and Clinics, Iowa, IA, USA 2 Division of Neurology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Brain 138:3180-92. 2015
    ..and establish baseline clinical data for peripheral neuropathies caused by mutations in the myelin protein zero (MPZ) gene. MPZ mutations are the second leading cause of Charcot-Marie-Tooth disease type 1...

Research Grants85

  1. Metabolism and Carcinogenicity of Heterocyclic Amines
    TERRY ZENSER; Fiscal Year: 2007
    ..Dextran sulfate sodium (DSS)-induced colitis is an animal model for studying both inflammation and colitis-associated neoplasia...
  2. Early and Late Onset CMT1B
    Michael E Shy; Fiscal Year: 2010
    ..Human mutations in MPZ give rise to peripheral demyelinating neuropathies, Charcot Marie Tooth disease type IB (CMT1B)...
  3. Vincent W Yang; Fiscal Year: 2016
    ..In addition, it was shown recenty that KLF5 is necessary for mucosal healing in the dextran sulfate sodium (DSS) mouse model of colitis...
  4. Lori A Coburn; Fiscal Year: 2016
    ..Eotaxin-1 has been shown to be increased in dextran sulfate sodium (DSS) induced colitis by my collaborator, and we now show for the first time that eotaxin-1 is upregulated in: 1) ..
  5. Keith T Wilson; Fiscal Year: 2016 effective as a treatment for epithelial injury and inflammation induced by dextran sulfate sodium (DSS), a model that mimics UC. CAT2 expression, L-Arg uptake, and L-Arg levels are all decreased in UC tissues...
  6. Yatrik M Shah; Fiscal Year: 2016
    ..This will be examined in a well-characterized CAC model using azoxymethane (AOM) and dextran sulfate sodium (DSS) in mice that are disrupted for HIF2a or mice that overexpress HIF2a specifically in the colon...
  7. A novel agent suppresses colitis and colon cancer
    Nengtai Ouyang; Fiscal Year: 2013
    ..this proposal, we will further confirm and refine the inhibitory effect of the peptide in dextran sulfate sodium (DSS)-induced acute colitis mouse model. The mechanism by which this peptide suppresses colitis will also be explored...
  8. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..Specific Aims: Establish the pharmacodynamic profile of mR-421 in mice utilizing 1) a dextran sulfate sodium (DSS) model and 2) a dintrobenzenesulfonic (DNBS) model of intestinal inflammation Treatment with mR-421 (3, 10, and 30 ..
  9. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
    ..2. To evaluate the therapeutic efficacies of ceramidase inhibitors in the DSS model of ulcerative colitis...
  10. Dezheng Zhao; Fiscal Year: 2016
    ..have shown that Nur77 is highly induced in acute trisnitrobenzene sulfonic acid (TNBS) and dextran sulfate sodium (DSS) experimental colitis...
  11. Progranulin Intervention in Inflammatory Bowel Diseases
    Chuanju Liu; Fiscal Year: 2013
    ..preliminary studies that the deletion of the PGRN gene renders B6 mice more susceptible to Dextran Sulfate Sodium (DSS) induction and to developing more severe colitis...
  12. The impact of Helicobacter pylori infection on inflammatory bowel disease suscept
    John Kao; Fiscal Year: 2009
    ..2. To study the impact of H. pylori-induced Tregs on mouse susceptibility to chronic dextran sulfate sodium (DSS)-colitis. 2.1. To demonstrate the presence of extragastric H. pylori-specific Tregs response induced by H...
  13. Novel Intervention for Colitis
    MICHAEL VITEK; Fiscal Year: 2007
    ..rodentium) model, an acute Dextran Sulfate Sodium (DSS) model and a chronic DSS model of colitis...
  14. The Role of a Novel Vitamin E Metabolite in Colon Cancer Prevention and Therapy
    Qing Jiang; Fiscal Year: 2012
    ..model, in which colon carcinogenesis is induced by azoxymethane (AOM) and is accelerated by dextran sulfate sodium (DSS)-caused colon inflammation...
  15. Inducible colon-specific transgenic mouse for cancer research
    James C Fleet; Fiscal Year: 2013
    ..Additional studies will be done in the presence of colonic inflammation induced by dextran sulfate sodium (DSS)...
  16. Colorectal cancer chemoprevention with phytochemical combinations
    Swati Nagar; Fiscal Year: 2013
    ..efficacy from Aim 1 will be tested in a dextran sulfate sodium + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (DSS/PhIP) colon adenocarcinoma mouse model, and aberrant crypt foci (ACF), tumor size/frequency, and ugt induction will ..
  17. Yan Cui; Fiscal Year: 2016
    ..myeloid precursors synergistically enhances chronic inflammation and tumorigenesis in the dextran sulfate sodium (DSS)-induced colon cancer, whereas targeted restoration of p53 in fibroblast or MDSC delays colon cancer development...
  18. Joanne Wang; Fiscal Year: 2015
    ..and toxins (e.g. MPP+, paraquat) are hydrophilic organic cations (OCs) that do not readily cross cell membranes by passive diffusion...
  19. Prema Robinson; Fiscal Year: 2014
    ..In preliminary studies, we demonstrated that C188-9 almost completely prevents dextran sodium sulphate (DSS)-induced colitis in mice...
  20. Antioxidants and Antiinflammatory in Colorectal Cancer
    Ah Ng Tony Kong; Fiscal Year: 2012
    ..inflammation and oxidative stresses, Nrf2-deficient mice were found to be more susceptible to inflammatory agent DSS-induced colitis...
  21. Hamed Laroui; Fiscal Year: 2016
    ..We have demonstrated that DSS-induced colitis is aggravated in villin-CD98 transgenic mice (in which CD98 is expressed in colonocytes) than wild-..
  22. Identification of Lactobacillus Secreted Factors in Regulation of Pgp
    Seema Saksena; Fiscal Year: 2013
    ..Further, a decrease in function and expression of Pgp has been shown in experimental mouse model of DSS-induced colitis...
  23. Amar B Singh; Fiscal Year: 2015
    ..3) Cl-2Tg mice are significantly protected from experimental-colitis [induced using dextran sodium sulfate (DSS, 4% w/v in drinking water)] compared to WT littermates (p<0.001)...
  24. 15-LOX-1 effects on colitis and colon cancer
    Imad Shureiqi; Fiscal Year: 2012
    ..acid (supplemented to colonic crypt cells) into 13-S-HODE and PGE2 in mice treated with dextran sodium sulfate (DSS) to induce colitis. Aim 2: To determine whether 15-LOX-1 suppresses chronic colitis...
  25. Vincent W Yang; Fiscal Year: 2014 lipopolysaccharide (LPS), pathogenic bacterial infection by Citrobacter rodentium, and dextran sodium sulfate (DSS)-induced colitis...
  26. Babak Oskouian; Fiscal Year: 2016
    ..We now show that SPL is also downregulated in tumors that develop in azoxymethane/dextran sodium sulfate (AOM/DSS)-treated mice. Thus, SPL downregulation is a common feature of intestinal neoplasia...
  27. Soluble epoxide hydrolase as a novel target of colitis-induced carcinogenesis
    Guang Yu Yang; Fiscal Year: 2012
    ..are performed: 1) Determine the role of sEH in colitis-induced carcinogenesis using sEH knockout mice in our novel DSS-induced carcinogenesis model, and a spontaneous colitis-carcinogenesis model in double-knockout (sEH and IL-10) ..
  28. The role of ErbB-4 in inflammation-induced colon carcinogenesis
    Mark R Frey; Fiscal Year: 2011
    ..expression of ErbB-4 isoforms during tumorigenesis and determining the effect of ErbB-4 deletion on AOM/DSS tumorigenesis in vivo;(2) Define the role(s) of full-length and intracellular domain ErbB-4 isoforms in intestinal ..
  29. Hans Christian Reinecker; Fiscal Year: 2016
    ..that overexpression of IL-22BP impaired the recovery from acute colitis induced by dextran sodium sulfate (DSS). However, only little information is currently available on the IL-22BP in any research fields, including IBD...
  30. Chemoprevention of Colitis-Associated Neoplasia by 5-ASA
    Margie L Clapper; Fiscal Year: 2012
    ..acid (5-ASA), the first-line therapy for the treatment of human colitis, to inhibit the multiplicity of AOM/DSS-induced colitis-associated dysplasias in mice when given prior to the induction of colitis...
  31. Eugene Chang; Fiscal Year: 2016
    ..intensifying the inflammatory response, (3) gene-targeted deletion of Hsp70 transforms the otherwise, self-limited, DSS-induced colitis to a chronic, IBD-like colitis, and (4) after AOM/DSS challenge, multi-focal, flat dysplasia-to-..
    Pauline K Lund; Fiscal Year: 2013
    ..Aim 1 will define the cellular and molecular mechanisms and gene targets associated with enhanced AOM/DSS-induced tumorigenesis in mice with IEC-SOCS3 deletion...
    ..Hypothesis 2.2 is tested that A3Rs confer protection in genomic models of colitis. It is tested using DSS in C57BL/6 A3 KO or FVB/N profilin transctenic mice with 8-fold up-regulation of A3Rs...
  34. Mark R Frey; Fiscal Year: 2016
    ..colonocytes from cytokine-induced apoptosis both in vitro and in vivo, and reduces the severity of acute murine DSS colitis...
  35. Darren D Browning; Fiscal Year: 2016
    ..activation by PDE-5 inhibitors on barrier function, inflammation, and tumorigenesis using Prkg2-/- mice and both DSS/AOM and ApcMin/+ mouse cancer models...
  36. Dietary Prevention of Cancer
    Shrikant Anant; Fiscal Year: 2013
    ..efficacy of a combination of curcumin and marmelin in preventing intestinal and colonic tumorigenesis in the AOM/DSS-induced mouse colon cancer model...
  37. Environmental Toxicants and Neurodegeneration
    Kim Tieu; Fiscal Year: 2010
    ..Based on our preliminary data we hypothesize that cations such as MPP+ (1-methyl-4-phenylpyridinium) and paraquat (PQ) are bi- directionally transported across the astrocytic plasma ..
  38. Neuroprotection by Mitochondria-targeted Antioxidants
    ..targeted antioxidants (MTAs) inhibit oxidative stress and neuronal damage in 1-methyl-4- phenylpyridinium (MPP+) treated neuronal cell culture models of PD as well as in 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) ..
  39. Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
    Matam Vijay Kumar; Fiscal Year: 2013
    ..Interestingly, SCD-1 deficiency exacerbates intestinal inflammation in an acute model of Dextran Sodium Sulfate (DSS) and C. rodentium induced colitis and SCD-1 overexpression significantly attenuated such colitis...
  40. Anisa Shaker; Fiscal Year: 2016
    ..We will extend these observations to the dextran sodium sulfate (DSS) colitis and azoxymethane (AOM)/DSS CAC models...
  41. Claire Larmonier; Fiscal Year: 2014
    ..dispensable in T-cells, while Parp1-/- mice are protected from colitis resulting from epithelial damage induced by DSS. These data collectively suggests that the pathogenic role of Parp1 in colitis is restricted to either colonic ..
  42. Kara Gross Margolis; Fiscal Year: 2016
    ..expression of genes encoding proinflammatory molecules, levels of neutrophil elastase and p50 NF B) of TNBS- and DSS-induced colitis are higher in NSE- noggin and lower in Hand2+/- mice than in their wild-type (WT) littermates...
  43. Development of the orally delivered, non-absorbable ACE inhibitor enalaprilat for
    ELKE LIPKA; Fiscal Year: 2010
    ..We have recently demonstrated the ability to palliate the progression of colitis in a mouse dextran sodium sulfate (DSS) model through blockage of signaling via the inhibition of the angiotensin-converting enzyme (ACE) in the renin-..
  44. NICHOLAS DAVIDSON; Fiscal Year: 2016
    ..intestinal lipotoxicity and that both Mttp-IKO and Apobec-1-/- mice demonstrate increased mortality with DSS colitis which is further exacerbated in the double knockout background...
  45. The developing intestinal immune system in Yersinia enterocolitica infection
    REBECCA D ADKINS; Fiscal Year: 2010
    ..enterocolitica and Salmonella) engineered to express only YopP will be applied to modulate inflammation in DSS-induced colitis in neonates. In addition, cell types critical for Y...
  46. ROSE LINDA SZABADY; Fiscal Year: 2015
    ..and will broaden the applicability of these findings by investigating the regulation of HXA3 activity by AMEND in DSS colitis and T cell transfer, two established mouse models of non-infectious colitis...
  47. Protease Pathways in the Gastrointestinal Tract
    Toni M Antalis; Fiscal Year: 2010
    ..segments, and dramatically enhances susceptibility to experimental colitis induced by dextran sodium sulfate (DSS)...
  48. Oral anti-TNF antibody for inflammatory bowel disease
    Daniel E Tracey; Fiscal Year: 2013
    ..antibody specific for murine TNF) significantly reduced the severity of colitis in the well-established TNBS and DSS mouse models of IBD while blood levels remained low...
  49. SIMON PATRICK HOGAN; Fiscal Year: 2015
    ..We will employ S100A9-/-, RAGE-/-, CCR2-/-, CCR2-/-/Il10-/- mice;use DSS- and NSAID-induced Il10-/- models of colitis;generate bone marrow-derived M[unreadable]-specific chimeric mice and ..
  50. Sandra J Gendler; Fiscal Year: 2014
    ..the periphery, (3) To determine the effect of a lack of Muc1 in myeloid development during dextran sodium sulfate (DSS)-induced colitis and colitis associated cancer (CAC) by using chimeric mice that lack or have Muc1 in the ..
  51. Epithelial-mesenchymal interactions in gut morphogenesis
    Deborah C Rubin; Fiscal Year: 2010
    ..3. Determine mechanisms by which epimorphin deletion ameliorates injury induced by DSS, and whether this enhances carcinogenesis associated with DSS-induced injury/inflammation...
  52. The role of the mu-Opioid Receptor in Inflammatory Bowel Disease Pathology and Th
    Jason R Goldsmith; Fiscal Year: 2013
    ..Preliminary data shows that MOR agonist ameliorates DSS colitis. However, the mechanism of action of DSS- mediated protection remains unknown...
  53. Bobak Parang; Fiscal Year: 2015
    ..induce intestinal injury in BVES-/- mice using two complementary animals models of colitis: dextran sodium sulfate (DSS) and Citrobacter rodentium infection...
  54. THERESA TORRES PIZARRO; Fiscal Year: 2014
    ..We will first study the effect of intestinal injury induced by DSS in mice deficient in TL1A and DR3...
  55. David M Underhill; Fiscal Year: 2015
    ..We have observed that mice lacking Dectin-1 are more susceptible to acute colitis induced by DSS than wild type mice and that this enhanced sensitivity is due to intestinal fungi...
  56. Arianne L Theiss; Fiscal Year: 2014
    ..inflammatory bowel disease (IBD) and experimental colitis, and 4) prohibitin transgenic mice are protected from DSS- and Salmonella typhimurium-induced colitis and oxidative stress...
  57. Sergei I Grivennikov; Fiscal Year: 2015
    ..For a long time our lab has used a azoxymethane+DSS induced CAC mouse model to mimic CAC development in humans...
  58. The Role of Interleukin 23 In Colitis Associated Cancer
    Sergei I Grivennikov; Fiscal Year: 2012
    ..For a long time our lab has used a azoxymethane+DSS induced CAC mouse model to mimic CAC development in humans...
  59. Control of colonic motility in health and disease.
    Sushil K Sarna; Fiscal Year: 2012
    ..induced colonic inflammation that mimics the classic features of Crohn's disease, and dextran sodium sulfate (DSS) - induced colonic inflammation that mimics those of ulcerative colitis...
    William F Stenson; Fiscal Year: 2013
    ..Hyaluronic acid is produced in response to gastrointestinal injury in the DSS colitis model and in radiation injury in the small intestine. 2...
  61. Terrence A Barrett; Fiscal Year: 2015
    ..Data already produced in VilCre/pik3r1fl/fl mice given DSS colitis suggest that PI3K-mediated B-catenin activation plays a major role in wound healing...
  62. The Impact of TLR on Intestinal Tumorigenesis
    Eyal Raz; Fiscal Year: 2010
    ..Thus, in SA-2, we will treat Apc, and Apc mutants (see above) with the colitis-inducing chemical, DSS, followed by oral administration of UO126 or Sorafenib (a RAS-RAF inhibitor)...
    Lars Eckmann; Fiscal Year: 2010
    ..Our initial studies show that mice homozygous for this mutation exhibit greater acute inflammation in the DSS-induced model of colitis, and their macrophages are more responsive to MDP, displaying enhanced activation of NFKB ..
  64. GC-C agonists for colitis-induced CRC
    Kunwar Shailubhai; Fiscal Year: 2009
    ..Recently, we also demonstrated that treatment with SP304 ameliorated GI inflammation in DSS- and TNBS- induced colitis models...
  65. Molecular pathogenesis of SIMPLE in Charcot-Marie-Tooth disease
    MING HIN LEE; Fiscal Year: 2010
    ..Imaging studies of Schwann cells acquired from human patients and rodent disease models of CMT subtypes (CMT1A and CMT1B) revealed accumulations of peripheral myelin proteins, namely, peripheral myelin protein 22 (PMP22) and myelin ..
  66. Elizabeth A Fortunato; Fiscal Year: 2014
    ..Fine mapping of the chromosome 1q breaksites has revealed two genes, nidogen 1 (NID1) and myelin protein zero (MPZ), linked to the development of hearing loss in infected infants...
  67. Early Events in Colitis-Associated Colorectal Cancer
    Wen Chi Chang; Fiscal Year: 2003
    ..The dextran sulfate sodium (DSS) model of induced colitis provides a unique opportunity to evaluate the spectrum of histological changes that lead ..
  68. Extra-nigral Neurodegeneration in Experimental Parkinson's Disease
    Naren L Banik; Fiscal Year: 2013
    ..Since 1-methyl-4-phenylpyridinium ion (MPP+), the active toxic metabolite of MPTP, increases intracellular-free Ca2+ level and promotes mitochondrial ..
  69. Michael E Shy; Fiscal Year: 2016
    ..Two Clinical Research Projects will be performed. Dr. Shy, from WSU, will undertake a natural history analysis of CMT1B, CMT2A, and CMT4A...
  70. Pathogenesis of Myelin Protein Zero Neuropathies in Transgenic Mice
    Lawrence Wrabetz; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): We propose to identify the intracellular pathogenesis of Myelin Protein Zero (MPZ)-related neuropathies...
  71. Ah Ng Tony Kong; Fiscal Year: 2016
    ..cancer cells and inhibits NFkB;an analog of CUR dibenzoylmethane, inhibits adenomas in APCmin mice, and CRC in AOM-DSS mice;(3) CUR regulate Nrf2-dependent genes in the intestine using Nrf2 KO mice;(4) As TRAMP mouse PCa progresses, ..
    PHILLIP CHANCE; Fiscal Year: 1992
    ..The biochemical basis of these conditions is unknown. The locus of one autosomal dominant variant (HMSNIb) has been assigned to chromosome 1 by linkage to the Duffy blood group locus...
  73. A Novel Cytoprotective Peptide for GI Epithelial Cell
    FREDERICK TOBACK; Fiscal Year: 2005
    ..epithelial cell (Caco-2/bbe) cultures subjected to injury by an oxidant, indomethacin, or dextran sulfate sodium (DSS) used to induce colitis in mice, Studies in cell culture indicate that this AMP peptide activates p38 MAP kinase, ..
    PATRICIA SONSALLA; Fiscal Year: 2004
    ..1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its toxic metabolite 1-methyl-4-phenylpyridinium (MPP+) have provided much insight into mechanisms of neurodegeneration of DA neurons...
  75. James Versalovic; Fiscal Year: 2016
    ..In Aims 2 and 3, two different mouse models (DSS-ApcMin/+ and Hdc-/-) will be used to explore the importance of L-histidine metabolism and histamine generation in ..
  76. Mark C Horowitz; Fiscal Year: 2014
    ..During the early stages of hematopoietic cell differentiation multipotential progenitor (MPP) cells can give rise to either myeloid progenitors or B lymphocyte progenitors...
    Chang An Yu; Fiscal Year: 2009
    ..studied two more functions of QCR, superoxide radical generation and mitochondrial processing peptidase activity (MPP)...
  78. Mucus-penetrating nanoparticles for sustained microbicide delivery
    Justin Hanes; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): We have developed mucus-penetrating nanoparticles (MPP) suitable for sustained delivery of small-molecule microbicides (Lai et al, Proceedings of the National Academy of Sciences 2007;104(5):1482-7)...
  79. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..CMT is divided in two major types, CMT1 and CMT2, based on nerve conduction velocities, which are reduced in CMT1 and relatively normal in CMT2...
  80. Skin Pigmentation and Parkinson's Disease Risk
    Caroline Tanner; Fiscal Year: 2003
    ..The toxic form of this compound, MPP+, was shown to bind to neural melanin; leading to the proposal that dermal melanin may "protectively" bind ..