MPHOSPH9

Summary

Gene Symbol: MPHOSPH9
Description: M-phase phosphoprotein 9
Alias: MPP-9, MPP9
Species: human

Top Publications

  1. ncbi Genes associated with multiple sclerosis: 15 and counting
    Mario Habek
    School of Medicine, University of Zagreb, Croatia
    Expert Rev Mol Diagn 10:857-61. 2010
  2. doi The relationship between maximal exercise-induced increases in serum IL-6, MPO and MMP-9 concentrations
    D Reihmane
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Scand J Immunol 76:188-92. 2012
  3. doi Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: possible implications for corneal ulcer formation in ocular rosacea
    Niamh O'Reilly
    Department of Biology, NUI Maynooth, Co Kildare, Ireland
    Invest Ophthalmol Vis Sci 53:3250-9. 2012
  4. doi Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9
    Apostolia Fragkouli
    Laboratory of Cell and Matrix Pathobiology, Institute of Biology, NCSR Demokritos, Athens, Greece
    J Neurochem 121:239-51. 2012
  5. pmc Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    Philip L De Jager
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 41:776-82. 2009
  6. doi Effects of doxycycline on production of growth factors and matrix metalloproteinases in pulmonary fibrosis
    Hanako Fujita
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respiration 81:420-30. 2011
  7. pmc An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings
    Benjamin A Goldstein
    Division of Biostatistics, School of Public Health, University of California, Berkeley, CA, USA
    BMC Genet 11:49. 2010
  8. pmc Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication
    Maija Wolf
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    BMC Cancer 10:181. 2010
  9. pmc Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score
    Philip L De Jager
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet Neurol 8:1111-9. 2009
  10. doi Transcriptional analysis of buffalo (Bubalus bubalis) oocytes during in vitro maturation using bovine cDNA microarray
    O M Kandil
    Department of Animal Reproduction and A I, National Research Centre, Dokki, Giza, Egypt
    Reprod Domest Anim 45:63-74. 2010

Research Grants

Scientific Experts

  • Philip L De Jager
  • Maija Wolf
  • Benjamin A Goldstein
  • D Reihmane
  • Niamh O'Reilly
  • Apostolia Fragkouli
  • Hanako Fujita
  • Mario Habek
  • O M Kandil
  • Keiko Imamura
  • Gregg R Ward
  • Kevin Kavanagh
  • Clair Gallagher
  • Kishore Reddy Katikireddy
  • Martin Clynes
  • Spiros Georgopoulos
  • Athina K Tzinia
  • Effie C Tsilibary
  • Antonios Stamatakis
  • Finbarr O'Sullivan
  • Costas Papatheodoropoulos
  • Fotini Stylianopoulou
  • Misato Amenomori
  • Hiroshi Ishimoto
  • Atsuko Hara
  • Towako Nagata
  • Noriho Sakamoto
  • Hiroshi Mukae
  • Shigeru Kohno
  • Shintaro Hara
  • Yuji Ishimatsu
  • Tomoyuki Kakugawa
  • Vesna V Brinar
  • K Schellander
  • C Phatsara
  • N Ghanem
  • Fran Borovecki
  • M Holker
  • D Tesfaye
  • A S S Abdoon
  • Takao Takeshima
  • Kenji Nakashima
  • Emi Fusayasu
  • Krystal T Dempsey
  • Allyn C Howlett
  • Tonya M Gerald
  • Darrel E Clodfelter
  • Kruti M Patel
  • Kent E Vrana
  • Steven O Franklin
  • Dan J Krissinger
  • N Matsumoto-Taniura
  • J M Westendorf
  • R Monroe
  • L Gerace
  • F Pirollet

Detail Information

Publications13

  1. ncbi Genes associated with multiple sclerosis: 15 and counting
    Mario Habek
    School of Medicine, University of Zagreb, Croatia
    Expert Rev Mol Diagn 10:857-61. 2010
    Evaluation of: The International Multiple Sclerosis Genetics Consortium (IMSGC). IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes Immun. 11(5), 397-405 (2010)...
  2. doi The relationship between maximal exercise-induced increases in serum IL-6, MPO and MMP-9 concentrations
    D Reihmane
    Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Scand J Immunol 76:188-92. 2012
    ..Furthermore, correlation between increases in serum IL-6 and MMP-9 concentrations may suggest that IL-6 could exert modulatory effects on MMP-9 release during maximal exercise...
  3. doi Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: possible implications for corneal ulcer formation in ocular rosacea
    Niamh O'Reilly
    Department of Biology, NUI Maynooth, Co Kildare, Ireland
    Invest Ophthalmol Vis Sci 53:3250-9. 2012
    ..The aim of the work presented here was to establish the response of a corneal epithelial cell line (hTCEpi) to protein extracted from a bacterium (Bacillus oleronius) previously isolated from a Demodex mite from a rosacea patient...
  4. doi Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9
    Apostolia Fragkouli
    Laboratory of Cell and Matrix Pathobiology, Institute of Biology, NCSR Demokritos, Athens, Greece
    J Neurochem 121:239-51. 2012
    ..Moreover, elevated sAPPα levels in the hippocampus and cortex of MPP9 transgenic animals were also observed...
  5. pmc Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    Philip L De Jager
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 41:776-82. 2009
    ....
  6. doi Effects of doxycycline on production of growth factors and matrix metalloproteinases in pulmonary fibrosis
    Hanako Fujita
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respiration 81:420-30. 2011
    ..Doxycycline hydrochloride (DOXY), an inhibitor of MMPs, attenuates pulmonary fibrosis in models and in patients with IPF; however, the mechanism of this action remains obscure...
  7. pmc An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings
    Benjamin A Goldstein
    Division of Biostatistics, School of Public Health, University of California, Berkeley, CA, USA
    BMC Genet 11:49. 2010
    ..One such approach is the Random Forests (RF) algorithm. The use of RF for SNP discovery related to human disease has grown in recent years; however, most work has focused on small datasets or simulation studies which are limited...
  8. pmc Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication
    Maija Wolf
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
    BMC Cancer 10:181. 2010
    ..Here, we present a framework, which integrates DNA, RNA and tissue data to identify and prioritize genetic events that represent clinically relevant new therapeutic targets and prognostic biomarkers for neuroblastoma...
  9. pmc Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score
    Philip L De Jager
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet Neurol 8:1111-9. 2009
    ..We investigated the usefulness of an aggregate measure of risk of MS that is based on genetic susceptibility loci. We also assessed the added effect of environmental risk factors that are associated with susceptibility for MS...
  10. doi Transcriptional analysis of buffalo (Bubalus bubalis) oocytes during in vitro maturation using bovine cDNA microarray
    O M Kandil
    Department of Animal Reproduction and A I, National Research Centre, Dokki, Giza, Egypt
    Reprod Domest Anim 45:63-74. 2010
    ..Among these, transcription factors (ZFP91), M-phase mitotic cell cycle (MPHOSPH9), growth factor (BMP15) and DNA binding (HMGN2) were found to be up-regulated in immature oocytes...
  11. ncbi Increased plasma matrix metalloproteinase-9 levels in migraineurs
    Keiko Imamura
    Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
    Headache 48:135-9. 2008
    ..To seek their possible association, we investigated plasma MMP-9 levels in migraineurs during headache-free periods...
  12. ncbi Glucocorticoids plus opioids up-regulate genes that influence neuronal function
    Gregg R Ward
    Neuroscience of Drug Abuse Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
    Cell Mol Neurobiol 27:651-60. 2007
    ..FRS2 (fibroblast growth factor receptor substrate-2; CTNNB1 (beta1-catenin); PRCP (prolyl-carboxypeptidase); MPHOSPH9 (M-phase phosphoprotein 9); and ZFP95 (zinc finger protein 95) serve important neuronal functions in signal ..
  13. pmc Identification of novel M phase phosphoproteins by expression cloning
    N Matsumoto-Taniura
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 7:1455-69. 1996
    ..Three MPPS were strikingly localized to interphase structures: MPP7 to centers of DNA replication, MPP9 to the Golgi complex, and MPP10 to nucleoli. In mitosis, most of the MPPs were distributed throughout the cells...

Research Grants1