monoglyceride lipase

Summary

Gene Symbol: monoglyceride lipase
Description: monoglyceride lipase
Alias: HU-K5, HUK5, MAGL, MGL, monoglyceride lipase, lysophospholipase homolog, monoacylglycerol lipase
Species: human
Products:     monoglyceride lipase

Top Publications

  1. Müller T, Reichwald K, Brönner G, Kirschner J, Nguyen T, Scherag A, et al. Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. Child Adolesc Psychiatry Ment Health. 2008;2:33 pubmed publisher
    ..degrading enzymes fatty acid amide hydrolase (FAAH), N-acylethanolamine-hydrolyzing acid amidase (NAAA) and monoglyceride lipase (MGLL) are implicated in mediating the orexigenic effects of cannabinoids...
  2. Nomura D, Long J, Niessen S, Hoover H, Ng S, Cravatt B. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell. 2010;140:49-61 pubmed publisher
    ..Here, we show that the enzyme monoacylglycerol lipase (MAGL) is highly expressed in aggressive human cancer cells and primary tumors, where it regulates a ..
  3. Bhatia G, Bansal V, Harismendy O, Schork N, Topol E, Frazer K, et al. A covering method for detecting genetic associations between rare variants and common phenotypes. PLoS Comput Biol. 2010;6:e1000954 pubmed publisher
    ..The data suggests that the RVs help disrupt the expression of the two genes, leading to lowered metabolism of the corresponding cannabinoids. Overall, our results point to the power of including RVs in measuring genetic associations. ..
  4. Aschauer P, Zimmermann R, Breinbauer R, Pavkov Keller T, Oberer M. The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition. Sci Rep. 2018;8:8948 pubmed publisher
    ..We present the crystal structure of the MGL Rv0183 from Mycobacterium tuberculosis (mtbMGL) in open conformation...
  5. Riegler Berket L, Leitmeier A, Aschauer P, Dreveny I, Oberer M. Identification of lipases with activity towards monoacylglycerol by criterion of conserved cap architectures. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:679-687 pubmed publisher
    Monoacylglycerol lipases (MGL) are a subclass of lipases that predominantly hydrolyze monoacylglycerol (MG) into glycerol and fatty acid...
  6. Mascarenhas S, Mutnuri S, Ganguly A. Deleterious role of trace elements - Silica and lead in the development of chronic kidney disease. Chemosphere. 2017;177:239-249 pubmed publisher
    ..6), resulting in borderline-lead (9.98 ?gL-1) and high-silica (115.5 mgL-1)contamination...
  7. Mai P, Yang L, Tian L, Wang L, Jia S, Zhang Y, et al. Endocannabinoid System Contributes to Liver Injury and Inflammation by Activation of Bone Marrow-Derived Monocytes/Macrophages in a CB1-Dependent Manner. J Immunol. 2015;195:3390-401 pubmed publisher
    ..lipase-α) and CBs were markedly increased, whereas degradative enzymes (fatty acid amidohydrolase and monoacylglycerol lipase) were downregulated...
  8. Zhang H, Wen J, Zhang Y, Limbu S, Du Z, Qin J, et al. Forskolin reduces fat accumulation in Nile tilapia (Oreochromis niloticus) through stimulating lipolysis and beta-oxidation. Comp Biochem Physiol A Mol Integr Physiol. 2019;230:7-15 pubmed publisher
    ..Lipolysis related genes (ATGL, hormone-sensitive lipase, HSL; monoacylglycerol lipase, MGL; and protein kinase cAMP-activated catalytic subunit, PKAC) and β-oxidation genes (PPARα; fatty ..
  9. Carmany D, Walz A, Hsu F, Benton B, Burnett D, Gibbons J, et al. Activity Based Protein Profiling Leads to Identification of Novel Protein Targets for Nerve Agent VX. Chem Res Toxicol. 2017;30:1076-1084 pubmed publisher
    ..As with previously published ABPP OP work, monoacylglycerol lipase associated proteins and fatty acid amide hydrolase (FAAH) were shown to be targets of VX...

More Information

Publications138 found, 100 shown here

  1. Wang C, Saar V, Leung K, Chen L, Wong G. Human amyloid ? peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans. Neurobiol Dis. 2018;109:88-101 pubmed publisher
    ..Early B-cell Factor, EBF1 (unc-3), d-amino-acid oxidase, DAO (daao-1), glutamate receptor, metabotropic 1, GRM1 (mgl-2), prolyl 4-hydroxylase subunit alpha 2, P4HA2 (dpy-18 and phy-2). Taken together, our C...
  2. Wen J, Jones M, Tanaka M, Selvaraj P, Symes A, Cox B, et al. WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms. J Neuroinflammation. 2018;15:9 pubmed publisher
    ..Unlike the inhibition of the principal 2-arachidonyl glycerol (2-AG) hydrolytic enzyme monoacylglycerol lipase (MAGL), which leads to 2-AG overload and cannabinoid receptor desensitization, selective inhibition of ..
  3. McConn B, Koskinen A, Denbow D, Gilbert E, Siegel P, Cline M. Central injection of oxytocin reduces food intake and affects hypothalamic and adipose tissue gene expression in chickens. Domest Anim Endocrinol. 2019;67:11-20 pubmed publisher
    ..Adipose tissue abundance of fatty acid-binding protein 4, monoglyceride lipase (MGLL), MT, and perilipin-1 mRNA was greater in LWS than HWS chicks...
  4. Quiroga A, Lehner R. Pharmacological intervention of liver triacylglycerol lipolysis: The good, the bad and the ugly. Biochem Pharmacol. 2018;155:233-241 pubmed publisher
    ..to be centered in the adipose and to be catalyzed by only two lipases, hormone-sensitive lipase (HSL) and monoacylglycerol lipase (MAGL)...
  5. Pagano E, Borrelli F, Orlando P, Romano B, Monti M, Morbidelli L, et al. Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis. Pharmacol Res. 2017;119:227-236 pubmed publisher
    ..b>Monoacylglycerol lipase (MAGL), a serine hydrolase that inactivates 2-AG, is highly expressed in aggressive human cancer cells...
  6. Eggink L, Roby K, Cote R, Kenneth Hoober J. An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides. J Immunother Cancer. 2018;6:28 pubmed publisher
    ..human type II, C-type lectin receptor macrophage galactose-type lectin/C-type lectin receptor family member 10A (MGL/CLEC10A/CD301) that is expressed prominently by human peripheral immature dendritic cells, dendritic cells in the ..
  7. Rodriguez Sanchez I, Guindon J, Ruiz M, Tejero M, Hubbard G, Martínez de Villarreal L, et al. The endocannabinoid system in the baboon (Papio spp.) as a complex framework for developmental pharmacology. Neurotoxicol Teratol. 2016;58:23-30 pubmed publisher
    ..CNR1 and CNR2, respectively), and synthesizing/degrading enzymes (FAAH, fatty-acid amide hydrolase; MAGL, monoacylglycerol lipase; DAGL-α, diacylglycerol lipase-alpha)...
  8. Senga S, Kobayashi N, Kawaguchi K, Ando A, Fujii H. Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-κB) signaling in cancer cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:1057-1067 pubmed publisher
    ..significantly induced downregulation of the genes expression, such as hormone-sensitive lipase (HSL), monoacylglycerol lipase (MAGL), elongation of long-chain fatty acid member 6 (Elovl6), and acyl-CoA synthetase long-chain family ..
  9. Malik Z, Baik D, Schey R. The role of cannabinoids in regulation of nausea and vomiting, and visceral pain. Curr Gastroenterol Rep. 2015;17:429 pubmed publisher
    ..Novel drug targets such as FAAH and monoacylglycerol lipase (MAGL) inhibitors appear to be promising in animal models, but more studies are necessary to prove their ..
  10. Watson R, Gates A, Wynn E, Calvert F, Girousse A, Lelliott C, et al. Lyplal1 is dispensable for normal fat deposition in mice. Dis Model Mech. 2017;10:1481-1488 pubmed publisher
    ..Further studies will be required to clarify its physiological role. ..
  11. Weathers P, Elfawal M, Towler M, Acquaah Mensah G, Rich S. Pharmacokinetics of artemisinin delivered by oral consumption of Artemisia annua dried leaves in healthy vs. Plasmodium chabaudi-infected mice. J Ethnopharmacol. 2014;153:732-6 pubmed publisher
    ..64 mgL(-1) and ?120 min, respectively...
  12. Dias Rocha C, Almeida M, Santana E, Costa J, Franco J, Pazos Moura C, et al. Maternal high-fat diet induces sex-specific endocannabinoid system changes in newborn rats and programs adiposity, energy expenditure and food preference in adulthood. J Nutr Biochem. 2018;51:56-68 pubmed publisher
    ..ligands, cannabinoid receptors (CB1 and CB2), and the enzymes fatty acid anandamide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)...
  13. Wang W, Khalil Ur Rehman M, Feng J, Tao J. RNA-seq based transcriptomic analysis of CPPU treated grape berries and emission of volatile compounds. J Plant Physiol. 2017;218:155-166 pubmed publisher
    ..grapes was evaluated under field conditions. A concentration response was observed over a range of 0, 5, and 10 mgL-1 CPPU that was applied to fruitlets (mean diameter 6mm) at 2 weeks after full bloom...
  14. Piro J, Suidan G, Quan J, Pi Y, O Neill S, Ilardi M, et al. Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury. J Neuroinflammation. 2018;15:142 pubmed publisher
    ..of LPS and focal photothrombotic ischemic insult, respectively, in the presence and absence of the monoacylglycerol lipase (MAGL) inhibitor, CPD-4645...
  15. Ao J, Ding Y, Chen Y, Mu Y, Chen X. Molecular Characterization and Biological Effects of a C-Type Lectin-Like Receptor in Large Yellow Croaker (Larimichthys crocea). Int J Mol Sci. 2015;16:29631-42 pubmed publisher
    ..The CTLD of LycCTLR possesses six highly conserved cysteine residues (C1-C6), a conserved WI/MGL motif, and two sugar binding motifs, EPD (Glu-Pro-Asp) and WYD (Trp-Tyr-Asp)...
  16. Karwad M, Couch D, Theophilidou E, Sarmad S, Barrett D, Larvin M, et al. The role of CB1 in intestinal permeability and inflammation. FASEB J. 2017;31:3267-3277 pubmed publisher
    ..by inhibiting their metabolizing enzymes URB597 (a fatty acid amide hydrolase inhibitor) and JZL184 (a monoacylglycerol lipase inhibitor). Inflammation and ischemia were simulated with TNF-? and IFN-? and oxygen deprivation...
  17. Fortuoso B, Dos Reis J, Gebert R, Barreta M, Griss L, Casagrande R, et al. Glycerol monolaurate in the diet of broiler chickens replacing conventional antimicrobials: Impact on health, performance and meat quality. Microb Pathog. 2019;129:161-167 pubmed publisher
    ..Therefore, our hypothesis is that MGL can replace conventional antimicrobials, being a new alternative to poultry farming...
  18. Lee J, Hong S, Kwon H, Park S, Rhee E, Park C, et al. Exendin-4 improves ER stress-induced lipid accumulation and regulates lipin-1 signaling in HepG2 cells. Cell Stress Chaperones. 2018;23:629-638 pubmed publisher
    ..mRNA and increased the expression of genes encoding lipolytic enzymes hormone-sensitive lipase (HSL) and monoacylglycerol lipase (MGL) and VLDL assembly-associated proteins microsomal triglyceride transfer protein (MTP) and ..
  19. Tingaud Sequeira A, Raldúa D, Lavie J, Mathieu G, Bordier M, Knoll Gellida A, et al. Functional validation of ABHD12 mutations in the neurodegenerative disease PHARC. Neurobiol Dis. 2017;98:36-51 pubmed publisher
    ..T202I and p.R352* mutations, and the associated PHARC. Measuring ABHD12 monoacylglycerol lipase activity in transfected HEK293 cells demonstrated inhibition with mutated isoforms...
  20. Machover D, Rossi L, Hamelin J, Desterke C, Goldschmidt E, Chadefaux Vekemans B, et al. Effects in cancer cells of the recombinant L-Methionine gamma-lyase from Brevibacterium aurantiacum. Encapsulation in human erythrocytes for sustained L-methionine elimination. J Pharmacol Exp Ther. 2019;: pubmed publisher
    ..purified and characterized the recombinant pyridoxal 5'-phosphate (PLP)-dependent L-methionine gamma-lyase MGL-BL929 from the cheese-ripening Brevibacterium aurantiacum...
  21. Ohara M, Fukui T, Ouchi M, Watanabe K, Suzuki T, Yamamoto S, et al. Relationship between daily and day-to-day glycemic variability and increased oxidative stress in type 2 diabetes. Diabetes Res Clin Pract. 2016;122:62-70 pubmed publisher
    ..Glucose variability, mean glucose level (MGL), mean amplitude of glycemic excursions (MAGE), mean of daily differences (MODD) in glucose levels and area under ..
  22. Abolghasemi A, Dirandeh E, Ansari Pirsaraei Z, Shohreh B. Dietary conjugated linoleic acid supplementation alters the expression of genes involved in the endocannabinoid system in the bovine endometrium and increases plasma progesterone concentrations. Theriogenology. 2016;86:1453-1459 pubmed publisher
    ..phospholipase D (NAPEPLD), fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA), and monoglyceride lipase (MGLL) was measured by real-time PCR...
  23. Torres L, Balestrin N, Spelta L, Duro S, Pistis M, Marcourakis T. Exposure to tobacco smoke during the early postnatal period modifies receptors and enzymes of the endocannabinoid system in the brainstem and striatum in mice. Toxicol Lett. 2019;302:35-41 pubmed publisher
    ..and fatty acid amino hydrolase (FAAH) levels and increased in diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) levels during infancy and decreased CB2 and FAAH levels during adulthood...
  24. Phongsisay V. The immunobiology of Campylobacter jejuni: Innate immunity and autoimmune diseases. Immunobiology. 2016;221:535-43 pubmed publisher
    ..TRIF), sialic acid-binding immunoglobulin-like lectins (Siglecs), macrophage galactose-type lectin (MGL), and immunoglobulin-like receptors (TREM2, LMIR5/CD300b)...
  25. Khalid S, Hashmi I, Jamal Khan S, Qazi I, Nasir H. Effect of metal ions and petrochemicals on bioremediation of chlorpyrifos in aerobic sequencing batch bioreactor (ASBR). Environ Sci Pollut Res Int. 2016;23:20646-20660 pubmed
    ..98 % CP removal was observed in sequencing batch reactors at inoculum level, 10 %; pH, 7; CP concentration, 400 mgL-1, and HRT, 48 h. Experimental data has shown an excellent fit to first order growth model...
  26. Dirandeh E, Ghaffari J. Effects of feeding a source of omega-3 fatty acid during the early postpartum period on the endocannabinoid system in the bovine endometrium. Theriogenology. 2018;121:141-146 pubmed publisher
    ..phospholipase D (NAPEPLD), fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA), monoglyceride lipase (MGLL)) and PGF2α. Results showed that dry matter intake and milk yield were not affected by diets...
  27. Biernacki M, Łuczaj W, Gęgotek A, Toczek M, Bielawska K, Skrzydlewska E. Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats. Toxicol Appl Pharmacol. 2016;301:31-41 pubmed publisher
    ..2-AG) and N-arachidonoyl-dopamine (NADA)] and CB1 receptor and the activities of FAAH and monoacylglycerol lipase (MAGL)...
  28. Smith D, Stanley C, Foss T, Boles R, McKernan K. Rare genetic variants in the endocannabinoid system genes CNR1 and DAGLA are associated with neurological phenotypes in humans. PLoS ONE. 2017;12:e0187926 pubmed publisher
  29. Patel S, Hill M, Cheer J, Wotjak C, Holmes A. The endocannabinoid system as a target for novel anxiolytic drugs. Neurosci Biobehav Rev. 2017;76:56-66 pubmed publisher
    ..eCBs recruitment by interfering with eCB-degradation, via fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), has been linked to reductions in anxiety-like behaviors in rodents and variation in human anxiety ..
  30. Ward S, O Sullivan J, Drakeford C, Águila S, Jondle C, Sharma J, et al. A novel role for the macrophage galactose-type lectin (MGL) receptor in mediating von Willebrand factor clearance. Blood. 2017;: pubmed publisher
    ..The macrophage galactose-type lectin (MGL) is a C-type lectin that binds to glycoproteins expressing terminal N-acetylgalactosamine or galactose residues...
  31. Sanchez Alavez M, Nguyen W, Mori S, Moroncini G, Viader A, Nomura D, et al. Monoacylglycerol Lipase Regulates Fever Response. PLoS ONE. 2015;10:e0134437 pubmed publisher
    ..However, recent studies have demonstrated that monoacyglycerol lipase (MAGL), through hydrolysis of the endocannabinoid 2-arachidonoylglycerol, provides a major source of AA for PGE2 ..
  32. Lu Y, Xu L, Shu W, Zhou J, Chen X, Xu Y, et al. Microbial mediated iron redox cycling in Fe (hydr)oxides for nitrite removal. Bioresour Technol. 2017;224:34-40 pubmed publisher
    ..The average nitrite removal rates of 1.28±0.08 and 0.65±0.02(mgL-1)h-1 were achieved with ferrihydrite and magnetite, respectively...
  33. Granchi C, Caligiuri I, Bertelli E, Poli G, Rizzolio F, Macchia M, et al. Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors. J Enzyme Inhib Med Chem. 2017;32:1240-1252 pubmed publisher
    b>Monoacylglycerol lipase is a serine hydrolase that plays a major role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol...
  34. Navia Paldanius D, Savinainen J, Laitinen J. Biochemical and pharmacological characterization of human ?/?-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). J Lipid Res. 2012;53:2413-24 pubmed publisher
    ..From these, monoacylglycerol lipase (MAGL) is well characterized and, on a quantitative basis, is the main 2-AG hydrolase...
  35. Gutiérrez Zapata H, Rojas K, Sanabria J, Rengifo Herrera J. 2,4-D abatement from groundwater samples by photo-Fenton processes at circumneutral pH using naturally iron present. Effect of inorganic ions. Environ Sci Pollut Res Int. 2017;24:6213-6221 pubmed publisher
    ..3 mg L-1) and adding 10 mg L-1 of hydrogen peroxide was effective to remove 24.3 mgL-1 of 2,4-dichlorophenoxyacetic acid (2,4-D) from groundwater samples by simulated solar irradiation (..
  36. Taschler U, Eichmann T, Radner F, Grabner G, Wolinski H, Storr M, et al. Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic μ-opioid receptor sensitivity. Br J Pharmacol. 2015;172:4419-29 pubmed publisher
    b>Monoglyceride lipase (MGL) degrades 2-arachidonoyl glycerol (2-AG), an endogenous agonist of cannabinoid receptors (CB1/2 )...
  37. Kulikova V, Anufrieva N, Revtovich S, CHERNOV A, Telegin G, Morozova E, et al. Mutant form C115H of Clostridium sporogenes methionine ?-lyase efficiently cleaves S-Alk(en)yl-l-cysteine sulfoxides to antibacterial thiosulfinates. IUBMB Life. 2016;68:830-5 pubmed publisher
    Pyridoxal 5'-phosphate-dependent methionine ?-lyase (MGL) catalyzes the ?-elimination reaction of S-alk(en)yl-l-cysteine sulfoxides to thiosulfinates, which possess antimicrobial activity...
  38. Oladipo O, Ezeokoli O, Maboeta M, Bezuidenhout J, Tiedt L, Jordaan A, et al. Tolerance and growth kinetics of bacteria isolated from gold and gemstone mining sites in response to heavy metal concentrations. J Environ Manage. 2018;212:357-366 pubmed publisher
    ..isolated from mining sites to 10 HMs (Cd, Hg, Ni, Al, Cr, Pb, Cu, Fe, Mn and Zn) at varied concentrations (25-600 mgL-1) were investigated...
  39. Holtfrerich A, Hanekamp W, Lehr M. (4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Eur J Med Chem. 2013;63:64-75 pubmed publisher
    Inhibitors of the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the principle enzymes involved in the degradation of endogenous cannabinoids like anandamide and 2-arachidonoylglycerol, have potential ..
  40. Irie T, Yamaguchi Y, Sumen A, Habe S, Horii Y, Nonaka N. Evaluation of the MGL method to detect Paragonimus eggs and its improvement. Parasitol Res. 2015;114:4051-8 pubmed publisher
    Dog feces containing 500 Paragonimus westermani eggs per gram were examined by the Medical General Laboratory (MGL), the simple sedimentation (SS), and the Army Medical School III (AMS III) methods...
  41. Mahmoud M, Abou Ali S, Elweshahy S. Microwave functionalization of titanium oxide nanoparticles with chitosan nanolayer for instantaneous microwave sorption of Cu(II) and Cd(II) from water. Int J Biol Macromol. 2018;111:393-399 pubmed publisher
    ..potential utilization of MES technique for removal and extraction of Cd(II) and Cu(II) at low concentration levels (mgL-1) from water samples was also explored...
  42. Kita Y, Yoshida K, Tokuoka S, Hamano F, Yamazaki M, Sakimura K, et al. Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2. PLoS ONE. 2015;10:e0133663 pubmed publisher
    ..the molecular basis of fever initiation, we examined lipopolysaccharides (LPS)-induced fever model in monoacylglycerol lipase (MGL)-deficient (Mgll-/-) mice, CB1 receptor-MGL compound-deficient (Cnr1-/-Mgll-/-) mice, cytosolic ..
  43. Karimi M, Hassanshahian M. Isolation and characterization of phenol degrading yeasts from wastewater in the coking plant of Zarand, Kerman. Braz J Microbiol. 2016;47:18-24 pubmed publisher
    ..The effect of four different concentrations of phenol (50, 125, 200 and 275) mgL(-1) was measured and three degradation patterns in these yeasts were observed...
  44. Gomes de Souza L, Oliveira L, Benini R, Rodella P, Costa Ferreira W, Crestani C. Involvement of endocannabinoid neurotransmission in the bed nucleus of stria terminalis in cardiovascular responses to acute restraint stress in rats. Br J Pharmacol. 2016;173:2833-44 pubmed publisher
    ..and/or the fatty acid amide hydrolase (FAAH) enzyme inhibitor URB597 (30 pmol 100 nL(-1) ) or the monoacylglycerol lipase (MAGL) enzyme inhibitor JZL184 (30 pmol 100 nL(-1) ) was microinjected into the BNST before the acute ..
  45. Viader A, Blankman J, Zhong P, Liu X, Schlosburg J, Joslyn C, et al. Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. Cell Rep. 2015;12:798-808 pubmed publisher
    ..2-AG signaling is terminated by enzymatic hydrolysis-a reaction that is principally performed by monoacylglycerol lipase (MAGL)...
  46. Berset J, Mermer S, Robel A, Walton V, Chien M, Field J. Direct residue analysis of systemic insecticides and some of their relevant metabolites in wines by liquid chromatography - mass spectrometry. J Chromatogr A. 2017;1506:45-54 pubmed publisher
    ..In five samples SPT-EN was detected in the mgL-1 range with a maximum concentration of 16...
  47. Pasquare S, Gaveglio V, Giusto N. Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes. Arch Biochem Biophys. 2009;488:121-9 pubmed
    ..glycerol by the sequential action of lipid phosphate phosphatase (LPP), diacylglycerol lipase (DAGL), and monoacylglycerol lipase (MAGL) in cerebral cortex (CC) synaptosomes...
  48. Henricks A, Berger A, Lugo J, Baxter Potter L, Bieniasz K, Craft R, et al. Sex differences in alcohol consumption and alterations in nucleus accumbens endocannabinoid mRNA in alcohol-dependent rats. Neuroscience. 2016;335:195-206 pubmed publisher
    ..in NAc N-acyl phosphatidylethanolamine phospholipase D (NAPEPLD), DAG lipase alpha (DAGL?), and monoacylglycerol lipase (MAGL) mRNA...
  49. McReynolds J, Doncheck E, Li Y, Vranjkovic O, Graf E, Ogasawara D, et al. Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex. Biol Psychiatry. 2018;84:85-94 pubmed publisher
    ..recapitulated by intra-PL injection of corticosterone, the CB1R agonist WIN 55,212-2, or the monoacylglycerol lipase inhibitor URB602...
  50. Rapoport E, Khaidukov S, Gaponov A, Pazynina G, Tsygankova S, Ryzhov I, et al. Glycan recognition by human blood mononuclear cells with an emphasis on dendritic cells. Glycoconj J. 2018;35:191-203 pubmed publisher
    ..cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2. In contrast, DC-SIGN is not apparently involved, even in case of mannose-rich glycans...
  51. Rahmani M, Shamsizadeh A, Moghadam Ahmadi A, Kaeidi A, Allahtavakoli M. Monoacylglycerol lipase inhibitor, JZL-184, confers neuroprotection in the mice middle cerebral artery occlusion model of stroke. Life Sci. 2018;198:143-148 pubmed publisher
    ..The therapeutic effects of JZL were observed as well as Aspirin. Based on the results, it seems that JZL can be considered as a good candidate for inhibition of stroke secondary injury in the case of delayed treatment. ..
  52. Nouri A, Zinatizadeh A. Process optimization of CNP removal from industrial soft drink wastewater in a single up flow A2O with continuous feed and intermittent discharge regime. Water Sci Technol. 2018;77:1524-1536 pubmed publisher
    ..The optimum region obtained was an HRT of 5-11 h, a mixed liquor suspended solids (MLSS) concentration of 4,000-4,700 mgL-1, and an aerator height of 46.25 cm, at the N/sCOD ratio of 0.1.
  53. Cheng B, Xie R, Dong L, Chen X. Metabolic Remodeling of Cell-Surface Sialic Acids: Principles, Applications, and Recent Advances. Chembiochem. 2016;17:11-27 pubmed publisher
    ..The metabolic glycan labeling (MGL) strategy has emerged as an invaluable chemical biology tool that enables metabolic installation of useful ..
  54. Zhang J, Chen C. Alleviation of Neuropathology by Inhibition of Monoacylglycerol Lipase in APP Transgenic Mice Lacking CB2 Receptors. Mol Neurobiol. 2018;55:4802-4810 pubmed publisher
    Inhibition of monoacylglycerol lipase (MAGL), the primary enzyme that hydrolyzes the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain, produces profound anti-inflammatory and neuroprotective effects and improves synaptic and ..
  55. Wiley J, Lefever T, Pulley N, Marusich J, Cravatt B, Lichtman A. Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice. Behav Pharmacol. 2016;27:479-84 pubmed publisher
    ..JZL184, a monoacylglycerol lipase inhibitor, was also tested. FAAH mice showed faster acquisition than FAAH mice...
  56. Liu H, Leng F, Chen P, Kueppers S. Pollutant removal characteristics of a two-influent-line BNR process performing denitrifying phosphorus removal: role of sludge recycling ratios. Water Sci Technol. 2016;74:2474-2482 pubmed
    ..6% of the average removal efficiency was obtained when the influent chemical oxygen demand (COD) ranged from 175.9 mgL-1 to 189.9 mgL-1...
  57. Morozova E, Anufrieva N, Davydov D, Komarova M, Dyakov I, Rodionov A, et al. Plasma methionine depletion and pharmacokinetic properties in mice of methionine ?-lyase from Citrobacter freundii, Clostridium tetani and Clostridium sporogenes. Biomed Pharmacother. 2017;88:978-984 pubmed publisher
    PK studies were carried out after a single i.v. administration of 500 and 1000 U/kg by measuring of MGL activity in plasma samples. L-methionine concentration was measured by mass spectrometry. After single i.v...
  58. Lauria S, Casati S, Ciuffreda P. Synthesis and characterization of a new fluorogenic substrate for monoacylglycerol lipase and application to inhibition studies. Anal Bioanal Chem. 2015;407:8163-7 pubmed publisher
    Human monoacylglycerol lipase (MAGL), a soluble serine hydrolase that belongs to the α/β hydrolase fold superfamily, regulates 2-arachidonoyl glycerol level in the endocannabinoid system, which is implicated in a number of ..
  59. Dean C, Hillard C, Seagard J, Hopp F, Hogan Q. Components of the cannabinoid system in the dorsal periaqueductal gray are related to resting heart rate. Am J Physiol Regul Integr Comp Physiol. 2016;311:R254-62 pubmed publisher
    ..acid amide hydrolase (FAAH), and it was negatively correlated with transcript levels of both FAAH and monoacylglycerol lipase (MAGL), a catabolic enzyme for 2-arachidonoylglycerol (2-AG)...
  60. Dashamiri S, Ghaedi M, Asfaram A, Zare F, Wang S. Multi-response optimization of ultrasound assisted competitive adsorption of dyes onto Cu (OH)2-nanoparticle loaded activated carbon: Central composite design. Ultrason Sonochem. 2017;34:343-353 pubmed publisher
    ..The effects of variables such as pH, initial dyes concentrations (mgL-1), and amount of sorbent (mg) and sonication time (min) on the dyes removal were studied...
  61. García D, Medina P, Zúñiga V. Toxicological features of maleilated polyflavonoids from Pinus radiata (D. Don.) as potential functional additives for biomaterials design. Food Chem Toxicol. 2017;109:1069-1078 pubmed publisher
    ..Toxicological profile was assessed by using three target species in a wide range of concentration (0.01-100 mgL-1)...
  62. Askari H, Ghaedi M, Dashtian K, Azghandi M. Rapid and high-capacity ultrasonic assisted adsorption of ternary toxic anionic dyes onto MOF-5-activated carbon: Artificial neural networks, partial least squares, desirability function and isotherm and kinetic study. Ultrason Sonochem. 2017;37:71-82 pubmed publisher
    ..The interactive and main effects of variables such as pH, initial dyes concentration (mgL-1), adsorbent dosage (mg) and sonication time (min) on removal percentage were studied by central ..
  63. Teng W, Liu G, Luo H, Zhang R, Xiang Y. Simultaneous sulfate and zinc removal from acid wastewater using an acidophilic and autotrophic biocathode. J Hazard Mater. 2016;304:159-65 pubmed publisher
    ..The formation of ZnS alleviated the inhibition from sulfide and sped the sulfate reduction. With 15 and 25 mgL(-1) Zn added, more than 99% of Zn was removed from the wastewater...
  64. Preechasuk L, Suwansaksri N, Ipichart N, Vannasaeng S, Permpikul C, Sriwijitkamol A. Hyperglycemia and glycemic variability are associated with the severity of sepsis in nondiabetic subjects. J Crit Care. 2017;38:319-323 pubmed publisher
    ..The mean glucose level (MGL) along with GV represented by standard deviation (SD) and the mean amplitude of glycemic excursion (MAGE) were ..
  65. Ogawa S, Kunugi H. Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants. Curr Neuropharmacol. 2015;13:760-75 pubmed
    ..Recently, endocannabinoid hydrolytic enzymes such as fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) have become new therapeutic targets in the treatment of MDD...
  66. Blanco E, Galeano P, Palomino A, Pavón F, Rivera P, Serrano A, et al. Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus. Eur Neuropsychopharmacol. 2016;26:477-92 pubmed publisher
    ..endocannabinoid synthesis/degradation ratios, especially NAPE-PLD/fatty acid amide hydrolase and DAGLα/monoacylglycerol lipase, suggesting a reduced endocannabinoid production associated with a compensatory up-regulation of CB1 ..
  67. Hartley N, Gunduz Cinar O, Halladay L, Bukalo O, Holmes A, Patel S. 2-arachidonoylglycerol signaling impairs short-term fear extinction. Transl Psychiatry. 2016;6:e749 pubmed publisher
    ..Here we utilized the monoacylglycerol lipase inhibitor JZL184 to selectively augment brain 2-AG levels combined with an auditory cue fear-conditioning ..
  68. Ohara M, Nagaike H, Goto S, Fukase A, Tanabe Y, Tomoyasu M, et al. Improvements of ambient hyperglycemia and glycemic variability are associated with reduction in oxidative stress for patients with type 2 diabetes. Diabetes Res Clin Pract. 2018;139:253-261 pubmed publisher
    ..The mean glucose level (MGL), mean amplitude of glycemic excursions (MAGE), mean of daily differences (MODD), percentage coefficient of ..
  69. Scalvini L, Vacondio F, Bassi M, Pala D, Lodola A, Rivara S, et al. Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL. Sci Rep. 2016;6:31046 pubmed publisher
    The function of monoacylglycerol lipase (MGL), a key actor in the hydrolytic deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2AG), is tightly controlled by the cell's redox state: oxidative signals such as hydrogen ..
  70. Jeong H, Paik Y. MGL-1 on AIY neurons translates starvation to reproductive plasticity via neuropeptide signaling in Caenorhabditis elegans. Dev Biol. 2017;430:80-89 pubmed publisher
    ..We discovered that in C. elegans, the glutamate receptor homolog MGL-1 initiated reproductive plasticity in response to starvation...
  71. Chicca A, Arena C, Manera C. Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases. Recent Pat CNS Drug Discov. 2016;10:122-141 pubmed
    ..last 10-15 years, many inhibitors for the main EC hydrolytic enzymes fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), ?,?-hydrolase domain-6 (ABHD6) and -12 (ABHD12) have been synthesized and characterized in vitro ..
  72. Tsoli M, Swarbrick M, Robertson G. Lipolytic and thermogenic depletion of adipose tissue in cancer cachexia. Semin Cell Dev Biol. 2016;54:68-81 pubmed publisher
    ..demand is normally mediated through a well-defined process of lipolysis involving the lipases ATGL, HSL and MGL. Studies into how these lipases contribute to fat loss in cancer cachexia have revealed the prominent role for ATGL ..
  73. Boutland A, Dange D, Stasch A, Maron L, Jones C. Two-Coordinate Magnesium(I) Dimers Stabilized by Super Bulky Amido Ligands. Angew Chem Int Ed Engl. 2016;55:9239-43 pubmed publisher
    ..with KC8 in the absence of coordinating solvents have afforded the first two-coordinate magnesium(I) dimers, LMg-MgL (R=Me, Pr(i) or Ph; R'=Pr(i) , or Me), in low to good yields...
  74. Navarrete F, García Gutiérrez M, Aracil Fernández A, Lanciego J, Manzanares J. Cannabinoid CB1 and CB2 Receptors, and Monoacylglycerol Lipase Gene Expression Alterations in the Basal Ganglia of Patients with Parkinson's Disease. Neurotherapeutics. 2018;15:459-469 pubmed publisher
    ..in the cannabinoid receptors CB1 (CB1r) and CB2 (A isoform, CB2Ar), and in monoacylglycerol lipase (MAGL) gene expression in the substantia nigra (SN) and putamen (PUT) of patients with PD...
  75. Greliche N, Germain M, Lambert J, Cohen W, Bertrand M, Dupuis A, et al. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. BMC Med Genet. 2013;14:36 pubmed publisher
    ..This study, the first genome-wide SNP interaction analysis conducted so far on VT risk, suggests that common SNPs are unlikely exerting strong interactive effects on the risk of disease. ..
  76. Riccardi L, Arencibia J, Bono L, Armirotti A, Girotto S, De Vivo M. Lid domain plasticity and lipid flexibility modulate enzyme specificity in human monoacylglycerol lipase. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:441-451 pubmed publisher
    Human monoacylglycerol lipase (MAGL) is a membrane-interacting enzyme that generates pro-inflammatory signaling molecules. For this reason, MAGL inhibition is a promising strategy to treat pain, cancer, and neuroinflammatory diseases...
  77. Hu W, Lian Y, Peng L, Lei J, Deng C, Xu M, et al. Monoacylglycerol lipase promotes metastases in nasopharyngeal carcinoma. Int J Clin Exp Pathol. 2014;7:3704-13 pubmed
    b>Monoacylglycerol lipase (MAGL) is a serine hydrolase that hydrolyzes monoacylglycerides into free fatty acids and glycerol...
  78. Mukherjee S, Sahu P, Halder G. Microbial remediation of fluoride-contaminated water via a novel bacterium Providencia vermicola (KX926492). J Environ Manage. 2017;204:413-423 pubmed publisher
    ..Maximum removal of 82% was achieved when the initial fluoride concentration was 20 mgL-1 at pH 7 and 37 °C temperature with dextrose and nitrogen concentrations of 5 and 4 g per 50 mL ..
  79. Chanda P, Gao Y, Mark L, Btesh J, Strassle B, Lu P, et al. Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. Mol Pharmacol. 2010;78:996-1003 pubmed publisher
    ..abundant endocannabinoid in the brain and is believed to be hydrolyzed primarily by the serine hydrolase monoacylglycerol lipase (MAGL)...
  80. Harismendy O, Bansal V, Bhatia G, Nakano M, Scott M, Wang X, et al. Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level. Genome Biol. 2010;11:R118 pubmed publisher
    ..covering 188 kb) encoding the endocannabinoid metabolic enzymes fatty-acid amide hydrolase (FAAH) and monoglyceride lipase (MGLL) in 147 normal controls and 142 extremely obese cases...
  81. Teh B, Lim K, Yong C, Ng C, Rao S, Rajasegaran V, et al. The draft genome of tropical fruit durian (Durio zibethinus). Nat Genet. 2017;49:1633-1641 pubmed publisher
    ..We observed paleopolyploidization events shared by durian and cotton and durian-specific gene expansions in MGL (methionine ?-lyase), associated with production of volatile sulfur compounds (VSCs)...
  82. Castillo E, Martinelli F, Zakharov Negre F, Ebeler S, Buzo T, McKenry M, et al. Effects of transgenic expression of Brevibacterium linens methionine gamma lyase (MGL) on accumulation of Tylenchulus semipenetrans and key aminoacid contents in Carrizo citrange. Plant Mol Biol. 2017;95:497-505 pubmed publisher
    ..semipenetrans aggregation and more biomass than infected WT control plants, indicating that they may represent an innovative management alternative to pesticide/nematicide-based remedies. ..
  83. Zhang X, Thayer S. Monoacylglycerol lipase inhibitor JZL184 prevents HIV-1 gp120-induced synapse loss by altering endocannabinoid signaling. Neuropharmacology. 2018;128:269-281 pubmed publisher
    b>Monoacylglycerol lipase (MGL) hydrolyzes 2-arachidonoylglycerol to arachidonic acid and glycerol. Inhibition of MGL may attenuate neuroinflammation by enhancing endocannabinoid signaling and decreasing prostaglandin (PG) production...
  84. Ye L, Zhang B, Seviour E, Tao K, Liu X, Ling Y, et al. Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer. Cancer Lett. 2011;307:6-17 pubmed publisher
    ..And recently findings of monoacylglycerol lipase provide a novel evidence in the correlation of obesity and cancer...
  85. van Zadelhoff G, Van Der Stelt M. Oxygenation of Anandamide by Lipoxygenases. Methods Mol Biol. 2016;1412:217-25 pubmed publisher
    ..2-arachidonoylglycerol are not only metabolized by serine hydrolases, such as fatty acid amide hydrolase, monoacylglycerol lipase, and α,β-hydrolases 6 and 12, but they also serve as substrates for cyclooxygenases and ..
  86. Qin H, Ruan Z. The role of monoacylglycerol lipase (MAGL) in the cancer progress. Cell Biochem Biophys. 2014;70:33-6 pubmed publisher
    ..have anti-tumorigenic actions, including anti-proliferation, apoptosis induction, and anti-metastatic effects, MAGL as an important decomposing enzyme of both lipid metabolism and endocannabinoids system, additionally as a part of ..
  87. Grabner G, Zimmermann R, Schicho R, Taschler U. Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling. Pharmacol Ther. 2017;175:35-46 pubmed publisher
    ..from the degradation of phospho- and neutral lipids, and monoglyceride lipase (MGL), also designated as monoacylglycerol lipase (MAGL), is the major enzyme catalyzing the hydrolysis of MGs into glycerol and fatty acids...
  88. Granchi C, Caligiuri I, Minutolo F, Rizzolio F, Tuccinardi T. A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017). Expert Opin Ther Pat. 2017;27:1341-1351 pubmed publisher
    b>Monoacylglycerol lipase is a serine hydrolase that plays a major role in the degradation of the endocannabinoid 2-arachidonoylglycerol...
  89. Zvonok N, Pandarinathan L, Williams J, Johnston M, Karageorgos I, Janero D, et al. Covalent inhibitors of human monoacylglycerol lipase: ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis. Chem Biol. 2008;15:854-62 pubmed publisher
    The active site of recombinant hexa-histidine-tagged human monoacylglycerol lipase (hMGL) is characterized by mass spectrometry using the inhibitors 5-((biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide (AM6701), and N-..
  90. Giusti B, Rossi L, Lapini I, Magi A, Pratesi G, Lavitrano M, et al. Gene expression profiling of peripheral blood in patients with abdominal aortic aneurysm. Eur J Vasc Endovasc Surg. 2009;38:104-12 pubmed publisher
    ..alteration of oxygen transport (increased hemoglobin gene expression) and lipid metabolism [including monoglyceride lipase and low density lipoprotein receptor-related protein 5 (LRP5) gene]...
  91. Nomura D, Lombardi D, Chang J, Niessen S, Ward A, Long J, et al. Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer. Chem Biol. 2011;18:846-56 pubmed publisher
    ..b>Monoacylglycerol lipase (MAGL) plays a principal role in this process by converting monoglycerides, including the endocannabinoid ..
  92. Yavari S, Malakahmad A, Sapari N, Yavari S, Khan E. Nutrient balancing for phytoremediation enhancement of urea manufacturing raw wastewater. J Environ Manage. 2017;202:225-231 pubmed publisher
    ..Twelve test solutions consisted of 4 levels of P (95, 190, 570, 1140 mgL-1) and 3 levels of K (95, 190, 570 mgL-1) with a constant level of N (190 mgL-1) ..