MOK

Summary

Gene Symbol: MOK
Description: MOK protein kinase
Alias: RAGE, RAGE-1, RAGE1, STK30, MAPK/MAK/MRK overlapping kinase, renal cell carcinoma antigen, renal tumor antigen 1
Species: human
Products:     MOK

Top Publications

  1. Hudson B, Stickland M, Futers T, Grant P. Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy. Diabetes. 2001;50:1505-11 pubmed
    Interactions between advanced glycation end products (AGEs) and the receptor for AGE (RAGE) are implicated in the vascular complications in diabetes...
  2. Kumaramanickavel G, Ramprasad V, Sripriya S, Upadyay N, Paul P, Sharma T. Association of Gly82Ser polymorphism in the RAGE gene with diabetic retinopathy in type II diabetic Asian Indian patients. J Diabetes Complications. 2002;16:391-4 pubmed
    ..This study aims to investigate the frequency of Gly82Ser polymorphism in exon 3 of the receptor for AGE (RAGE) gene and its association with DR in Asian Indian patients who have type II diabetes...
  3. Yoshioka K, Yoshida T, Takakura Y, Umekawa T, Kogure A, Toda H, et al. Relation between polymorphisms G1704T and G82S of rage gene and diabetic retinopathy in Japanese type 2 diabetic patients. Intern Med. 2005;44:417-21 pubmed
    To clarify whether polymorphisms G1704T and G82S of the rage gene were related to diabetic retinopathy, we performed a case-control study in Japanese type 2 diabetic patients...
  4. Damiani G, Campo I, Zorzetto M, Bozzi V, Disabella E, Caroli A, et al. Pro-inflammatory variants of DRB1 and RAGE genes are associated with susceptibility to pediatric type 1 diabetes: a new hypothesis on the adaptive role of autoimmunity. Riv Biol. 2007;100:285-304 pubmed
    Functional polymorphisms of two MHC genes (DRB1 and RAGE) were analysed in Italian pediatric patients with Type 1 diabetes and in a control group...
  5. Gu H, Yang L, Sun Q, Zhou B, Tang N, Cong R, et al. Gly82Ser polymorphism of the receptor for advanced glycation end products is associated with an increased risk of gastric cancer in a Chinese population. Clin Cancer Res. 2008;14:3627-32 pubmed publisher
    It has been shown that the expression of the receptor for advanced glycation end products (RAGE) is closely associated with invasion and metastasis in gastric cancer...
  6. Zhang H, Chen L, Wang L, Liao Y, Wu Z, Ye F, et al. Association of 1704G/T and G82S polymorphisms in the receptor for advanced glycation end products gene with diabetic retinopathy in Chinese population. J Endocrinol Invest. 2009;32:258-62 pubmed
    The receptor for advanced glycation end products (RAGE) plays an important role in the pathogenesis of diabetic complications...
  7. Mazzio E, Bauer D, Mendonça P, Taka E, Soliman K. Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2- in LPS/IFNγ activated glioma cells. J Neuroimmunol. 2017;302:10-19 pubmed publisher
    ..activin A, agrin, IL-1α, MIP-3a, B72/CD86, NGF, IL-1b, MMP-8, IL-1 R6, PDGF-AA, IL-2, IL-4, prolactin R, RAGE, IL-6, Thymus Chemokine-1, CNTF,IL-10 or TIMP-1...
  8. Xie W, Zhou P, Sun Y, Meng X, Dai Z, Sun G, et al. Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies. Cells. 2018;7: pubmed publisher
    ..ERS), high mobility group protein1 (HMGB1)-induced TLR2/4/9 and receptor for advanced glycation end products (RAGE) pathways, and the activation of NF-κB; neurological cell cycle, proliferation, differentiation, and regeneration ..
  9. Lee T, Bai K, Chen Y, Lee T, Chung C, Tsai W, et al. Histone deacetylase inhibition of cardiac autophagy in rats on a high?fat diet with low?dose streptozotocin-induced type 2 diabetes mellitus. Mol Med Rep. 2017;: pubmed publisher
    ..diphosphate ribose polymerase 1 (PARP1), insulin signaling, advanced glycosylation end product?specific receptor (RAGE), and proinflammatory cytokines in control rats and in rats treated with a high?fat diet (60% fat) and low?dose ..

More Information

Publications146 found, 100 shown here

  1. Aslani F, Schuppe H, Guazzone V, Bhushan S, Wahle E, Lochnit G, et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. Hum Reprod. 2015;30:417-31 pubmed publisher
    ..Interaction of HMGB1 and its receptors (RAGE, TLR4) as well signaling pathways after HMGB1 stimulation were studied in isolated TM, PTC and SC by proximity ..
  2. Chen Y, Wu Y, Gan X, Liu K, Lv X, Shen H, et al. Iridoid glycoside from Cornus officinalis ameliorated diabetes mellitus-induced testicular damage in male rats: Involvement of suppression of the AGEs/RAGE/p38 MAPK signaling pathway. J Ethnopharmacol. 2016;194:850-860 pubmed publisher
    ..was to investigate the therapeutic effects of IGCO on DM-induced testicular damage through inhibition of the AGEs/RAGE/p38 MAPK signaling pathway. A DM model of male Wistar rats was induced with streptozotocin injection (30mg/kg, i.p...
  3. Abdelmageed M, Shehatou G, Abdelsalam R, Suddek G, Salem H. Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1/PI3K/AKT2 pathway and AGEs/RAGE interaction. Naunyn Schmiedebergs Arch Pharmacol. 2019;392:243-258 pubmed publisher
    ..lipid profile, oxidative stress biomarkers, serum advanced glycation end products (AGEs) and its receptors (RAGE) in the aorta, and histopathology of the liver and aorta...
  4. Sun W, Jiao Y, Cui B, Gao X, Xia Y, Zhao Y. Immune complexes activate human endothelium involving the cell-signaling HMGB1-RAGE axis in the pathogenesis of lupus vasculitis. Lab Invest. 2013;93:626-38 pubmed publisher
    ..the first time that ICs upregulated cell surface expression of the receptor for advanced glycation end products (RAGE), the expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), ..
  5. Rajesh M, Batkai S, Kechrid M, Mukhopadhyay P, Lee W, Horváth B, et al. Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. Diabetes. 2012;61:716-27 pubmed publisher
    ..glycation end product (AGE) and angiotensin II type 1 receptors (receptor for advanced glycation end product [RAGE], angiotensin II receptor type 1 [AT(1)R]), p47(phox) NADPH oxidase subunit, β-myosin heavy chain isozyme switch, ..
  6. Abdel Mageid A, Abou Salem M, Salaam N, El Garhy H. The potential effect of garlic extract and curcumin nanoparticles against complication accompanied with experimentally induced diabetes in rats. Phytomedicine. 2018;43:126-134 pubmed publisher
    ..to determine relative of manganese-superoxide dismutase (Mn-SOD) and receptor for advanced glycation end products (RAGE) gene expressions in the heart tissue of rats...
  7. Wang Q, Zhou J, Xiang Z, Tong Q, Pan J, Wan L, et al. Anti-diabetic and renoprotective effects of Cassiae Semen extract in the streptozotocin-induced diabetic rats. J Ethnopharmacol. 2019;: pubmed publisher
    ..Immunohistochemical examination of kidney was measured to investigate the expression of RAGE in renal tissues...
  8. Zhong R, Xiao J, Yu Z, Zhou J, Dai C. [Research on the effect of protection against ventilator-induced lung injury via regulation of caveolin-1/heme oxygenase-1 signaling]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015;27:568-73 pubmed publisher
    ..The expressions of high mobility group B1 (HMGB1) and advanced glycation end product receptor (RAGE) in lung tissues were assayed with immunohistochemistry staining...
  9. Fusco F, Gomes D, Bispo K, Toledo V, Barbeiro D, Capelozzi V, et al. Low-sodium diet induces atherogenesis regardless of lowering blood pressure in hypertensive hyperlipidemic mice. PLoS ONE. 2017;12:e0177086 pubmed publisher
    ..Carboxymethyl-lysine (CML) and receptor for advanced glycation end products (RAGE) immunostaining was greater in H-LS than H-NS mice...
  10. Lv X, Lv G, Dai G, Sun H, Xu H. Food-advanced glycation end products aggravate the diabetic vascular complications via modulating the AGEs/RAGE pathway. Chin J Nat Med. 2016;14:844-855 pubmed publisher
    ..AGEs/RAGE/ROS pathway parameters were determined...
  11. Wang J, Zhang T, Liu X, Fan H, Wei C. Aqueous extracts of se-enriched Auricularia auricular attenuates D-galactose-induced cognitive deficits, oxidative stress and neuroinflammation via suppressing RAGE/MAPK/NF-κB pathway. Neurosci Lett. 2019;704:106-111 pubmed publisher
    ..Further, hippocampal levels of RAGE, p-Erk, p-JNK, p-P38 and p-NF-κB were detected by western blot and the RAGE expression was confirmed by ..
  12. Jin Z, Gao P, Liu Z, Jin B, Song G, Xiang T. Composition of Ophiopogon Polysaccharide, Notoginseng Total Saponins and Rhizoma Coptidis Alkaloids Inhibits the Myocardial Apoptosis on Diabetic Atherosclerosis Rabbit. Chin J Integr Med. 2018;: pubmed publisher
    ..in serum were measured by enzyme linked immunosorbent assay (ELISA) method; the expression of receptor of AGEs (RAGE) in myocardial tissue were observed by immunohistochemical method; and p-Jun N-terminal kinase (p-JNK), caspase-3, ..
  13. Yao L, Zhao H, Tang H, Liang J, Liu L, Dong H, et al. The receptor for advanced glycation end products is required for ?-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016;173:2600-13 pubmed publisher
    ..The aim of this study was to examine whether the receptor for advanced glycation end products (RAGE) can regulate ?-catenin expression in TDI-induced asthma...
  14. Toma L, Sanda G, Deleanu M, Stancu C, Sima A. Glycated LDL increase VCAM-1 expression and secretion in endothelial cells and promote monocyte adhesion through mechanisms involving endoplasmic reticulum stress. Mol Cell Biochem. 2016;417:169-79 pubmed publisher
    ..induces (i) stimulation of VCAM-1 expression and secretion, determining increased monocyte adhesion to HEC; (ii) RAGE up-regulation and free cholesterol loading; (iii) ERS activation (increased eIF2? phosphorylation and CHOP mRNA ..
  15. Suliman H, Kraft B, Bartz R, Chen L, Welty Wolf K, Piantadosi C. Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2017;313:L699-L709 pubmed publisher
    ..type I (AT1) cells assessed by bronchoalveolar lavage fluid receptor for advanced glycation end points (RAGE) levels was high, yet AT2 cell death was limited while both mitochondrial biogenesis and mitophagy were ..
  16. Hsu C, Yang H, Ho J, Yin M, Hsu J. Houttuynia cordata aqueous extract attenuated glycative and oxidative stress in heart and kidney of diabetic mice. Eur J Nutr. 2016;55:845-854 pubmed publisher
    ..05). Diabetes increased protein expression of RAGE, p47(phox) and gp91(phox), nuclear factor kappa-B (NF-κB) p50, NF-κB p65 and mitogen-activated protein kinase ..
  17. Giribabu N, Karim K, Kilari E, Salleh N. Phyllanthus niruri leaves aqueous extract improves kidney functions, ameliorates kidney oxidative stress, inflammation, fibrosis and apoptosis and enhances kidney cell proliferation in adult male rats with diabetes mellitus. J Ethnopharmacol. 2017;205:123-137 pubmed publisher
    ..Kidney somatic index, histopathological changes and levels of RAGE, Nrf2, oxidative stress markers (TBARS, SOD, CAT and GPx), inflammatory markers (NFkβ-p65, Ikk-β, TNF-α, ..
  18. Bodine B, Bennion B, Leatham E, Jimenez F, Wright A, Jergensen Z, et al. Conditionally induced RAGE expression by proximal airway epithelial cells in transgenic mice causes lung inflammation. Respir Res. 2014;15:133 pubmed publisher
    Receptors for advanced glycation end-products (RAGE) are multiligand cell-surface receptors expressed abundantly by distal pulmonary epithelium...
  19. Akutagawa K, Fujita T, Ouhara K, Takemura T, Tari M, Kajiya M, et al. Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice. Int Immunopharmacol. 2019;68:30-38 pubmed publisher
    ..HMGB1, one of the ligands of the receptor for advanced glycation end products (RAGE), is a damage-associated molecular pattern and induces inflammatory cytokine production...
  20. Mou K, Liu W, Han D, Li P. HMGB1/RAGE axis promotes autophagy and protects keratinocytes from ultraviolet radiation-induced cell death. J Dermatol Sci. 2017;85:162-169 pubmed publisher
    ..HMGB1 and its receptor (receptor for advanced glycation end products, RAGE) were both expressed by HaCaT cells, and HMGB1 was transferred from the nucleus to the cytoplasm after UV ..
  21. Song Z, Wang H, Liu M, Bai Y, Wang Y, Wang H. Involvement of S100A4/Mts1 and associated proteins in the protective effect of fluoxetine against MCT - Induced pulmonary hypertension in rats. J Chin Med Assoc. 2018;81:1077-1087 pubmed publisher
    ..the proliferation and migration of human pulmonary artery smooth muscle cells through the interaction with RAGE (receptor for advanced glycation end products) and thus S100A4/Mts1 has been implicated in the development of PAH ..
  22. Sanajou D, Ghorbani Haghjo A, Argani H, Roshangar L, Rashtchizadeh N, Ahmad S, et al. Reduction of renal tubular injury with a RAGE inhibitor FPS-ZM1, valsartan and their combination in streptozotocin-induced diabetes in the rat. Eur J Pharmacol. 2019;842:40-48 pubmed publisher
    Receptor for advanced glycation end-products (RAGE) is involved in the pathogenesis of diabetic nephropathy...
  23. Ren X, Ren L, Wei Q, Shao H, Chen L, Liu N. Advanced glycation end-products decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells. Cardiovasc Diabetol. 2017;16:52 pubmed publisher
    ..evoke oxidative and inflammatory reactions in endothelial cells through the interaction with a receptor for AGEs (RAGE)...
  24. Suchal K, Malik S, Khan S, Malhotra R, Goyal S, Bhatia J, et al. Molecular Pathways Involved in the Amelioration of Myocardial Injury in Diabetic Rats by Kaempferol. Int J Mol Sci. 2017;18: pubmed publisher
    ..end products (AGEs) which exerts its effect via interaction with the receptor for advanced glycation end products (RAGE). AGE-RAGE activation results in oxidative stress and inflammation...
  25. Yao X, Carlson D, Sun Y, Ma L, Wolf S, Minei J, et al. Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model. PLoS ONE. 2015;10:e0139416 pubmed publisher
    ..of mtDNA into the cytoplasm, inhibited up-regulation of Toll-like receptor 9 (TLR9) pathway factors MYD88 and RAGE, and limited RAGE interaction with its ligand TFAM in septic hearts...
  26. Moy K, Jiao L, Freedman N, Weinstein S, Sinha R, Virtamo J, et al. Soluble receptor for advanced glycation end products and risk of liver cancer. Hepatology. 2013;57:2338-45 pubmed publisher
    Binding of advanced glycation end products (AGEs) to their receptor (RAGE) increases oxidative stress and inflammation and may be involved in liver injury and subsequent carcinogenesis...
  27. Gasparotto J, Somensi N, Bortolin R, Girardi C, Kunzler A, Rabelo T, et al. Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage. J Nutr Biochem. 2014;25:1282-95 pubmed publisher
    ..necrosis factor (TNF)-α and interleukin (IL)-1β levels, and receptor for advanced glycation end-products (RAGE) and nuclear factor (NF)κB-p65 immunocontent] were investigated...
  28. Lok K, Basta M, Manzanero S, Arumugam T. Intravenous immunoglobulin (IVIg) dampens neuronal toll-like receptor-mediated responses in ischemia. J Neuroinflammation. 2015;12:73 pubmed publisher
    ..group box 1 (HMGB1), which activate toll-like receptors (TLRs) and receptor for advanced glycation endproducts (RAGE) in the affected area, leading to an exaggerated inflammatory response and cell death...
  29. Kim E, Na J, Kim J, Choi S, Ahn J, Cho S. Neuroprotective Effect of 3-(Naphthalen-2-Yl(Propoxy)Methyl)Azetidine Hydrochloride on Brain Ischaemia/Reperfusion Injury. J Neuroimmune Pharmacol. 2017;12:447-461 pubmed publisher
    ..putative kinase, uncoupling protein 2, p-Akt, MMP-3, and full-length receptor for advanced glycation end-products (RAGE). KHG26792 significantly improved neurological deficits and brain oedema and suppressed I/R-induced apoptosis...
  30. Palma Durán S, Kontogianni M, Vlassopoulos A, Zhao S, Margariti A, Georgoulis M, et al. Serum levels of advanced glycation end-products (AGEs) and the decoy soluble receptor for AGEs (sRAGE) can identify non-alcoholic fatty liver disease in age-, sex- and BMI-matched normo-glycemic adults. Metabolism. 2018;83:120-127 pubmed publisher
    ..Given the link of AGEs with end organ damage, there is scope to examine the role of the AGE/RAGE axis activation in liver injury and NAFLD...
  31. Yu Y, Bai F, Wang W, Liu Y, Yuan Q, Qu S, et al. Fibroblast growth factor 21 protects mouse brain against D-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation. Pharmacol Biochem Behav. 2015;133:122-31 pubmed publisher
    ..The expression of aldose reductase (AR), sorbitol dehydrogenase (SDH) and member-anchored receptor for AGEs (RAGE) declined significantly after FGF21 treatment...
  32. Didangelos A, Puglia M, Iberl M, Sanchez Bellot C, Roschitzki B, Bradbury E. High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury. Sci Rep. 2016;6:21607 pubmed publisher
    ..experiments, inhibition of toll-like receptor-4 (TLR4) and the receptor for advanced glycation end-products (RAGE) revealed the involvement of alarmins in inflammatory gene expression, which was found to be dominated by IL1 and ..
  33. López Díez R, Shen X, Daffu G, Khursheed M, Hu J, Song F, et al. Ager Deletion Enhances Ischemic Muscle Inflammation, Angiogenesis, and Blood Flow Recovery in Diabetic Mice. Arterioscler Thromb Vasc Biol. 2017;37:1536-1547 pubmed publisher
    ..We tested the hypothesis that advanced glycation end products (AGEs) and their receptor (RAGE) block angiogenesis and blood flow recovery after hindlimb ischemia induced by femoral artery ligation through ..
  34. Xu J, He Q, Li H, Yang C, Wang Y, Ai H. Modeling of methane formation in gravity sewer system: the impact of microorganism and hydraulic condition. AMB Express. 2018;8:34 pubmed publisher
    ..45 Pa, which was 1.2-fold higher than the minimum in sewer at 0.5 Pa. The R2 value of the established model was 0.95, the difference between the measurement and simulation was in the rage of 1.5-13.0%.
  35. Yamagishi S, Nakamura N, Suematsu M, Kaseda K, Matsui T. Advanced Glycation End Products: A Molecular Target for Vascular Complications in Diabetes. Mol Med. 2015;21 Suppl 1:S32-40 pubmed publisher
    ..There is a growing body of evidence indicating that interaction of AGEs with their receptor (RAGE) elicits oxidative stress generation and as a result evokes proliferative, inflammatory, thrombotic and fibrotic ..
  36. Manigrasso M, Pan J, Rai V, Zhang J, Reverdatto S, Quadri N, et al. Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction. Sci Rep. 2016;6:22450 pubmed publisher
    The receptor for advanced glycation endproducts (RAGE) binds diverse ligands linked to chronic inflammation and disease...
  37. Panksepp J. The Psycho-Neurology of Cross-Species Affective/Social Neuroscience: Understanding Animal Affective States as a Guide to Development of Novel Psychiatric Treatments. Curr Top Behav Neurosci. 2017;30:109-125 pubmed publisher
    ..They consist of the following neuronal processes: SEEKING/Enthusiasm, RAGE/Anger, FEAR/Anxiety, sexual LUST/Passion, maternal CARE/Nurturance, separation-distress PANIC/Grief and PLAY/Social ..
  38. Boor P, Celec P, Klenovicsová K, Vlkova B, Szemes T, Minarik G, et al. Association of biochemical parameters and RAGE gene polymorphisms in healthy infants and their mothers. Clin Chim Acta. 2010;411:1034-40 pubmed publisher
    ..Infant formulas contain high amounts of advanced glycation end-products (AGEs) - the ligands of RAGE. In this cross-sectional study, we examined the impact of G82S and -374 A/T polymorphisms in the gene encoding RAGE ..
  39. Peng T, Hu M, Wu T, Chen Z, Zhang C, Huang S, et al. Effects of high‑mobility group box 1 knockdown on proliferation, migration and invasion of the HONE‑1 human nasopharyngeal carcinoma cell line. Mol Med Rep. 2015;12:7531-7 pubmed publisher
    ..caspase‑3, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, receptor for advanced glycation end products (RAGE) as well as phosphorylated and total extracellular signal-regulated kinase 1/2 in HONE‑1 cells...
  40. Wang Z, Wang L, Wang L, Cheng S, Fan R, Zhou J, et al. Association between RAGE gene polymorphisms and ulcerative colitis susceptibility: a case-control study in a Chinese Han population. Genet Mol Res. 2015;14:19242-8 pubmed publisher
    ..was to investigate the association of three polymorphisms in the receptor for advanced glycation end-products (RAGE) gene with UC risk in a Chinese population...
  41. Kurt A, Andican G, Siva Z, Andican A, Burcak G. The effects of n-3 long-chain polyunsaturated fatty acid supplementation on AGEs and sRAGE in type 2 diabetes mellitus. J Physiol Biochem. 2016;72:679-687 pubmed
    ..Binding of AGEs to receptors of AGE (RAGE) causes deleterious effects...
  42. Zhou Z, Tang Y, Jin X, Chen C, Lu Y, Liu L, et al. Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NF?B Pathway Suppression. J Diabetes Res. 2016;2016:4847812 pubmed
    ..interleukin-1? (IL-1?), IL-6, and tumor necrosis factor-? (TNF-?)) mRNA expression, RAGE expression, and NF?B activation; (2) metformin pretreatment inhibited AGEs effects and AGEs-induced cluster ..
  43. Mir A, Moinuddin -, Habib S, Khan F, Alam K, Ali A. Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggregates with implications in auto-immune response in cancer. Glycobiology. 2016;26:129-41 pubmed publisher
    ..with carcinogenesis through advanced glycation end products (AGE)-receptors for advanced glycation end products (RAGE) axis...
  44. Afridi S, Aftab M, Murtaza M, Ghaffar S, Karim A, Mughal U, et al. A new glycotoxins inhibitor attenuates insulin resistance in liver and fat cells. Biochem Biophys Res Commun. 2016;476:188-195 pubmed publisher
    ..URM-II-81 reduced AGEs formation and receptor for advanced glycation end products (RAGE) expression in both cell types...
  45. Kato J, Agalave N, Svensson C. Pattern recognition receptors in chronic pain: Mechanisms and therapeutic implications. Eur J Pharmacol. 2016;788:261-273 pubmed publisher
    ..it is now evident that PRRs, such as toll-like receptors (TLRs) and receptors for advanced glycation end products (RAGE), are not only expressed in peripheral immune cells but also present in neurons and glial cells in the nervous ..
  46. Sakaguchi M, Kinoshita R, Putranto E, Ruma I, Sumardika I, Youyi C, et al. Signal Diversity of Receptor for Advanced Glycation End Products. Acta Med Okayama. 2017;71:459-465 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis...
  47. Muth I, Zschüntzsch J, Kleinschnitz K, Wrede A, Gerhardt E, Balcarek P, et al. HMGB1 and RAGE in skeletal muscle inflammation: Implications for protein accumulation in inclusion body myositis. Exp Neurol. 2015;271:189-97 pubmed publisher
    ..The "alarmin" HMGB1 is upregulated in muscle inflammation. Its receptor RAGE is crucial for β-amyloid-associated neurodegeneration...
  48. Sardina P, Martin J, Dzieza W, Braith R. Enhanced external counterpulsation (EECP) decreases advanced glycation end products and proinflammatory cytokines in patients with non-insulin-dependent type II diabetes mellitus for up to 6 months following treatment. Acta Diabetol. 2016;53:753-60 pubmed publisher
    ..4 %) and 2 weeks (+51.9 %) following EECP treatment. Our findings provide novel evidence that EECP decreases AGE/RAGE concentrations, inflammation, and oxidative stress in patients with T2DM that persist for up to 6 months following ..
  49. Park J, Li L, Choi J, Baek K. The Association of -429T>C and -374T>A Polymorphisms in the RAGE Gene with Polycystic Ovary Syndrome. Int J Med Sci. 2016;13:451-6 pubmed publisher
    ..Among these genetic factors, the receptor for advanced glycation end products (RAGE) that is associated with diabetes and involved in the complications of PCOS, was selected...
  50. Chakraborty D, Zenker S, Rossaint J, Hölscher A, Pohlen M, Zarbock A, et al. Alarmin S100A8 Activates Alveolar Epithelial Cells in the Context of Acute Lung Injury in a TLR4-Dependent Manner. Front Immunol. 2017;8:1493 pubmed publisher
    ..We also analyzed the contribution of the known S100-receptors TLR4 and RAGE in AEC activation...
  51. Wang H, Chen F, Du Y, Long Y, Reed M, Hu M, et al. Targeted inhibition of RAGE reduces amyloid-β influx across the blood-brain barrier and improves cognitive deficits in db/db mice. Neuropharmacology. 2018;131:143-153 pubmed publisher
    To investigate restorative effects of the receptor for advanced glycation end products (RAGE)-specific inhibitor FPS-ZM1 on abnormal amyloid β (Aβ) influx across the blood brain-barrier (BBB) and cognitive deficits in db/db mice...
  52. Good D, George T, Watts B. High-mobility group box 1 inhibits HCO(3)(-) absorption in medullary thick ascending limb through a basolateral receptor for advanced glycation end products pathway. Am J Physiol Renal Physiol. 2015;309:F720-30 pubmed publisher
    ..Inhibition by HMGB1 was eliminated by the receptor for advanced glycation end products (RAGE) antagonist FPS-ZM1 and by neutralizing anti-RAGE antibody...
  53. Wu J, Liu B, Liang C, Ouyang H, Lin J, Zhong Y, et al. Zhen-wu-tang attenuates cationic bovine serum albumin-induced inflammatory response in membranous glomerulonephritis rat through inhibiting AGEs/RAGE/NF-κB pathway activation. Int Immunopharmacol. 2016;33:33-41 pubmed publisher
    ..In addition, ZWT suppressed the expression of RAGE1 and NF-κB p65, as well as the nuclear translocation of NF-κB p65...
  54. Han A, Nam M, Lee K. Plantamajoside Inhibits UVB and Advanced Glycation End Products-Induced MMP-1 Expression by Suppressing the MAPK and NF-κB Pathways in HaCaT Cells. Photochem Photobiol. 2016;92:708-19 pubmed publisher
    ..Furthermore, PM attenuated the upregulation of receptor for AGEs (RAGE) by glycer-AGEs with UVB irradiation...
  55. Wautier M, Guillausseau P, Wautier J. Activation of the receptor for advanced glycation end products and consequences on health. Diabetes Metab Syndr. 2017;11:305-309 pubmed publisher
    ..Alternatively AGEs can be produced by glycolysis and oxidation. AGEs bind to a cellular receptor RAGE. RAGE engagement by ligands AGE, ?-amyloid peptide, and S100 calgranulin induces a stimulation of NADPH oxidase, ..
  56. Eskandari Nasab E, Hashemi M, Hasani S, Naderi M, Sadeghi Bojd S, Taheri M. Evaluation of functional RAGE gene polymorphisms in childhood acute lymphoblastic leukemia-A case-control study from Iran. Nucleosides Nucleotides Nucleic Acids. 2017;36:170-180 pubmed publisher
    We examined the possible relationship between three RAGE polymorphisms, -429C/T, -374 T/A, and 63-bp deletion, and susceptibility to childhood acute lymphoblastic leukemia (ALL) in an Iranian population...
  57. Oczypok E, Perkins T, Oury T. All the "RAGE" in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses. Paediatr Respir Rev. 2017;23:40-49 pubmed publisher
    The receptor for advanced glycation endproducts (RAGE) is a pro-inflammatory pattern recognition receptor (PRR) that has been implicated in the pathogenesis of numerous inflammatory diseases...
  58. Schmidt A. Soluble RAGEs - Prospects for treating & tracking metabolic and inflammatory disease. Vascul Pharmacol. 2015;72:1-8 pubmed publisher
    Emerging evidence links the receptor for advanced glycation endproducts (RAGE) to the pathogenesis of tissue damage in chronic metabolic and inflammatory diseases...
  59. Lim S, Dorajoo R, Zhang X, Wang L, Ang S, Tan C, et al. Genetic variants in the receptor for advanced glycation end products (RAGE) gene were associated with circulating soluble RAGE level but not with renal function among Asians with type 2 diabetes: a genome-wide association study. Nephrol Dial Transplant. 2017;32:1697-1704 pubmed publisher
    ..21 × 10-52), was a genotyped, missense SNP located on chromosome 6, corresponding to the RAGE (AGER) gene locus, the gene encoding RAGE...
  60. Pang X, Zhang Y, Zhang S. High-mobility group box 1 is overexpressed in cervical carcinoma and promotes cell invasion and migration in vitro. Oncol Rep. 2017;37:831-840 pubmed publisher
    ..Treatment with NF-?B inhibitor (BAY11-7082) and receptor for advanced glycation end products (RAGE) antagonist (anti-RAGE) significantly suppressed HMGB1?mediated epithelial-to-mesenchymal transition in the HeLa ..
  61. Shen C, Ma Y, Zeng Z, Yin Q, Hong Y, Hou X, et al. RAGE-Specific Inhibitor FPS-ZM1 Attenuates AGEs-Induced Neuroinflammation and Oxidative Stress in Rat Primary Microglia. Neurochem Res. 2017;42:2902-2911 pubmed publisher
    ..This process may occur due to direct cytotoxicity or interacting with AGEs receptors (RAGE), which are expressed on the surface of microglia...
  62. Chang Y, Lin C, Hsieh M, Wu H, Wu W, Wu W, et al. High mobility group B1 up-regulates angiogenic and fibrogenic factors in human retinal pigment epithelial ARPE-19 cells. Cell Signal. 2017;40:248-257 pubmed publisher
    ..Functional neutralization with anti-TLR4 and -RAGE antibodies confirmed that both receptors were involved in the cytokine overproduction...
  63. Zhan D, Guo L, Zheng L. Inhibition of the receptor for advanced glycation promotes proliferation and repair of human periodontal ligament fibroblasts in response to high glucose via the NF-κB signaling pathway. Arch Oral Biol. 2018;87:86-93 pubmed publisher
    To observe if inhibition of the receptor for advanced glycation endproducts (RAGE) promotes proliferation and repair of human periodontal ligament fibroblasts (hPDLFs) stimulated by high glucose...
  64. Sakellariou S, Fragkou P, Levidou G, Gargalionis A, Piperi C, Dalagiorgou G, et al. Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis. BMC Cancer. 2016;16:174 pubmed publisher
    Advanced glycation end products (AGEs) and their receptor RAGE emerge as important pathogenic contributors in colorectal carcinogenesis...
  65. Mrozek S, Jabaudon M, Jaber S, Paugam Burtz C, Lefrant J, Rouby J, et al. Elevated Plasma Levels of sRAGE Are Associated With Nonfocal CT-Based Lung Imaging in Patients With ARDS: A Prospective Multicenter Study. Chest. 2016;150:998-1007 pubmed publisher
    ..Plasma sRAGE is associated with a nonfocal ARDS. Such novel findings may suggest a role for RAGE pathway in an underlying endotype of impaired alveolar fluid clearance and stimulate future research on the ..
  66. Viana S, Valero J, Rodrigues Santos P, Couceiro P, Silva A, Carvalho F, et al. Regulation of striatal astrocytic receptor for advanced glycation end-products variants in an early stage of experimental Parkinson's disease. J Neurochem. 2016;138:598-609 pubmed publisher
    ..These agents operate through the receptor for advanced glycation end-products (RAGE), which displays distinct isoforms playing protective/deleterious effects...
  67. Nankali M, Karimi J, Goodarzi M, Saidijam M, Khodadadi I, Razavi A, et al. Increased Expression of the Receptor for Advanced Glycation End-Products (RAGE) Is Associated with Advanced Breast Cancer Stage. Oncol Res Treat. 2016;39:622-628 pubmed
    The receptor for advanced glycation end-products (RAGE) is a multiligand transmembrane receptor that is overexpressed in various pathological conditions including cancers...
  68. Reichert S, Triebert U, Santos A, Hofmann B, Schaller H, Schlitt A, et al. Soluble form of receptor for advanced glycation end products and incidence of new cardiovascular events among patients with cardiovascular disease. Atherosclerosis. 2017;266:234-239 pubmed publisher
    Soluble RAGE (sRAGE) serum level could be a biomarker for atherosclerosis and subsequent diseases such as cardiovascular disease (CVD)...
  69. Kim S, Ryu M, Han J, Jang Y, Kim J, Lee M, et al. Activation of the HMGB1-RAGE axis upregulates TH expression in dopaminergic neurons via JNK phosphorylation. Biochem Biophys Res Commun. 2017;493:358-364 pubmed publisher
    ..for how HMGB1 affects TH expression, particularly through the receptor for advanced glycation endproducts (RAGE), has not yet been investigated...
  70. Kankova K, Záhejský J, Marova I, Muzik J, Kuhrova V, Blazkova M, et al. Polymorphisms in the RAGE gene influence susceptibility to diabetes-associated microvascular dermatoses in NIDDM. J Diabetes Complications. 2001;15:185-92 pubmed
    To examine genetic polymorphism in the complete sequence of the Receptor of Advanced Glycation End products (RAGE) gene and its possible associations with diabetes-associated microvascular dermatoses (DAMD)...
  71. Hansen F, Battú C, Dutra M, Galland F, Lírio F, Broetto N, et al. Methylglyoxal and carboxyethyllysine reduce glutamate uptake and S100B secretion in the hippocampus independently of RAGE activation. Amino Acids. 2016;48:375-85 pubmed publisher
    ..However, glutamate uptake and S100B secretion were decreased after MG and CEL exposure. RAGE activation and glycation reactions, examined by aminoguanidine and L-lysine co-incubation, did not mediate these ..
  72. Park H, Ku S, Park H, Hong J, Kim D, Choi B, et al. RAGE siRNA-mediated gene silencing provides cardioprotection against ventricular arrhythmias in acute ischemia and reperfusion. J Control Release. 2015;217:315-26 pubmed publisher
    Expression of receptor for advanced glycation end-products (RAGE) is suggested to play a crucial role in mediating cardiac ischemia/reperfusion (IR) injury, and the blockade of RAGE signaling has been considered as a potential therapeutic ..
  73. Jangale N, Devarshi P, Bansode S, Kulkarni M, Harsulkar A. Dietary flaxseed oil and fish oil ameliorates renal oxidative stress, protein glycation, and inflammation in streptozotocin-nicotinamide-induced diabetic rats. J Physiol Biochem. 2016;72:327-36 pubmed publisher
    ..diets were able to limit the renal advanced glycation end products (AGEs) formation and reduced receptor of AGE (RAGE) protein expression significantly...
  74. Shao J, Zhao M, Tong M, Wei J, Wise M, Stone P, et al. Increased levels of HMGB1 in trophoblastic debris may contribute to preeclampsia. Reproduction. 2016;152:775-784 pubmed
    ..The expression of the receptor for advanced glycation end products (RAGE) in endothelial cells was quantified by western blotting...
  75. Yu Y, Wang L, Delguste F, Durand A, Guilbaud A, Rousselin C, et al. Advanced glycation end products receptor RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway. Free Radic Biol Med. 2017;112:397-410 pubmed publisher
    ..Blockade of receptor for advanced glycation end products (RAGE) attenuates vascular oxidative stress and development of atherosclerosis...
  76. Vanita V. Association of RAGE (p.Gly82Ser) and MnSOD (p.Val16Ala) polymorphisms with diabetic retinopathy in T2DM patients from north India. Diabetes Res Clin Pract. 2014;104:155-62 pubmed publisher
    The present study aimed to examine the association of RAGE (p.Gly82Ser) and MnSOD (p.Val16Ala) polymorphisms with diabetic retinopathy (DR) in north Indian T2DM patients...
  77. Lee A, Lam J, Shiu S, Wong Y, Betteridge D, Tan K. Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes. PLoS ONE. 2015;10:e0137330 pubmed publisher
    The receptor for advanced glycation end products (RAGE) is involved in the pathogenesis of diabetic complications, and soluble forms of the receptor (sRAGE) can counteract the detrimental action of the full-length receptor by acting as ..
  78. Wang J, Zeng J, Wang H, Ye S, Bi Y, Zhou Y, et al. Genetic polymorphisms of RAGE and risk of ulcerative colitis in a Chinese population. Immunol Lett. 2016;170:88-94 pubmed publisher
    The receptor for advanced glycation end products (RAGE) and its proinflammatory ligands are critically implicated in the pathological progression of ulcerative colitis (UC)...
  79. Lohani N, Rajeswari M. Dichotomous Life of DNA Binding High Mobility Group Box1 Protein in Human Health and Disease. Curr Protein Pept Sci. 2016;17:762-775 pubmed
    ..conditions HMGB1 displays inflammatory response by interaction with specific cell surface receptors like RAGE, TLR-4, TLR9, and TLR2 and activates NF-kB downstream signaling pathways...
  80. Yu W, Yang J, Sui W, Qu B, Huang P, Chen Y. Association of genetic variants in the receptor for advanced glycation end products gene with diabetic retinopathy: A meta-analysis. Medicine (Baltimore). 2016;95:e4463 pubmed publisher
    ..examined the association of DR with multiple genetic variants in the receptor for advanced glycation end products (RAGE) gene, with inconsistent results...
  81. Giurdanella G, Lazzara F, Caporarello N, Lupo G, Anfuso C, Eandi C, et al. Sulodexide prevents activation of the PLA2/COX-2/VEGF inflammatory pathway in human retinal endothelial cells by blocking the effect of AGE/RAGE. Biochem Pharmacol. 2017;142:145-154 pubmed publisher
    ..This mechanism, partially distinct from VEGF blockade, may contribute to the therapeutic effect of SDX. ..
  82. Yuan Y, Sun H, Sun Z. Advanced glycation end products (AGEs) increase renal lipid accumulation: a pathogenic factor of diabetic nephropathy (DN). Lipids Health Dis. 2017;16:126 pubmed publisher
    ..of the AGEs family) increased Oil Red O staining and intracellular cholesterol ester (CE) in HK-2 cells; Anti-RAGE (AGEs receptor) reduced lipid droplets and the CE level...
  83. Wautier M, Chappey O, Corda S, Stern D, Schmidt A, Wautier J. Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE. Am J Physiol Endocrinol Metab. 2001;280:E685-94 pubmed
    Engagement of the receptor for advanced glycation end products (RAGE) by products of nonenzymatic glycation/oxidation triggers the generation of reactive oxygen species (ROS), thereby altering gene expression...
  84. Kankova K, Stejskalova A, Hertlova M, Znojil V. Haplotype analysis of the RAGE gene: identification of a haplotype marker for diabetic nephropathy in type 2 diabetes mellitus. Nephrol Dial Transplant. 2005;20:1093-102 pubmed
    ..Common single nucleotide polymorphisms in the RAGE (receptor of advanced glycation end-products) gene (-429T/C, -374T/A, G82S, 1704G/T, 2184A/G and 2245G/A) were ..
  85. Dumitriu I, Bianchi M, Bacci M, Manfredi A, Rovere Querini P. The secretion of HMGB1 is required for the migration of maturing dendritic cells. J Leukoc Biol. 2007;81:84-91 pubmed
    ..The blockade of receptor for advanced glycation end products (RAGE), the best-characterized membrane receptor for HMGB1, impinges as well on the up-regulation of chemokine receptors ..
  86. Maruyama Y, Numata M, Nakayama M, Matsuo N, Nordfors L, Hosoya T, et al. Relationship between the -374T/A receptor of advanced glycation end products gene polymorphism and peritoneal solute transport status at the initiation of peritoneal dialysis. Ther Apher Dial. 2007;11:301-5 pubmed
    ..factor (VEGF), the endothelial nitric oxide synthase (eNOS) and the receptor for advanced glycation end product (RAGE) were analyzed by the pyrosequencing method...
  87. Falcone C, Geroldi D, Buzzi M, Emanuele E, Yilmaz Y, Fontana J, et al. The -374T/A RAGE polymorphism protects against future cardiac events in nondiabetic patients with coronary artery disease. Arch Med Res. 2008;39:320-5 pubmed publisher
    The -374T/A polymorphism of the Receptor for Advanced Glycation End products (RAGE) may exert a protective effect toward the development of atherosclerosis...
  88. Lasič E, Galland F, Vardjan N, Sribar J, Krizaj I, Leite M, et al. Time-dependent uptake and trafficking of vesicles capturing extracellular S100B in cultured rat astrocytes. J Neurochem. 2016;139:309-323 pubmed publisher
    ..Cell treatment with anti-receptor for advanced glycation end products (RAGE) antibody, which binds to RAGE, a 'scavenger receptor', partially inhibited uptake of S100B-Alexa488 , ..
  89. Hurtgen B, Ward C, Leopold Wager C, Garg K, Goldman S, Henderson B, et al. Autologous minced muscle grafts improve endogenous fracture healing and muscle strength after musculoskeletal trauma. Physiol Rep. 2017;5: pubmed publisher
    ..g., soluble RAGE) and leukocytes (e.g., monocytes), and depressed IGF-1 concentration, which GRAFT repair ameliorated...
  90. Matsumoto H, Matsumoto N, Shimazaki J, Nakagawa J, Imamura Y, Yamakawa K, et al. Therapeutic Effectiveness of Anti-RAGE Antibody Administration in a Rat Model of Crush Injury. Sci Rep. 2017;7:12255 pubmed publisher
    ..Receptor for advanced glycation endproducts (RAGE) functions as a pattern recognition receptor that regulates inflammation...
  91. Falcone C, Campo I, Emanuele E, Buzzi M, Zorzetto M, Sbarsi I, et al. Relationship between the -374T/A RAGE gene polymorphism and angiographic coronary artery disease. Int J Mol Med. 2004;14:1061-4 pubmed
    The receptor for advanced glycation end products (RAGE) is thought to play a critical role in diabetic atherosclerosis...
  92. Cho C, Chou R, Yu C. Pentamidine blocks the interaction between mutant S100A5 and RAGE V domain and inhibits the RAGE signaling pathway. Biochem Biophys Res Commun. 2016;477:188-94 pubmed publisher
    ..The extracellular domain of RAGE (Receptor of Advanced Glycation End products) contain three domains: C1, C2 and V...