Gene Symbol: MOB1B
Description: MOB kinase activator 1B
Alias: MATS2, MOB4A, MOBKL1A, MOB kinase activator 1B, MOB1 Mps One Binder homolog B, MOB1, Mps One Binder kinase activator-like 1A, mob1 homolog 1A, mob1A, mps one binder kinase activator-like 1A
Species: human
Products:     MOB1B

Top Publications

  1. Yuan H, Liu H, Liu Z, Zhu D, Amos C, Fang S, et al. Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival. Int J Cancer. 2015;137:638-45 pubmed publisher
    ..e., MST1, MST2, SAV1, LATS1, LATS2, MOB1A, MOB1B, YAP1, TEAD1, TEAD2, TEAD3 and TEAD4) from the dataset of our previously published CM genome-wide association ..
  2. Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, et al. MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene. 2017;36:4201-4211 pubmed publisher
    ..epithelium-specific, null mutations of MOB1A/B in mice (SPC-rtTA/(tetO)7-Cre/Mob1aflox/flox/Mob1b-/-; termed luMob1DKO mice). Most mutants (70%) receiving Dox in utero (luMob1DKO (E6.5-18...
  3. Xiong S, Couzens A, Kean M, Mao D, Guettler S, Kurinov I, et al. Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation. Mol Cell Proteomics. 2017;16:1111-1125 pubmed publisher
    ..Our previous interaction proteomics analysis revealed that beyond associating with MST1 (and MST2), MOB1A and MOB1B can associate in a phosphorylation-dependent manner with at least two other signaling complexes, one containing ..
  4. Sun T, Pepling M, Diaz F. Lats1 Deletion Causes Increased Germ Cell Apoptosis and Follicular Cysts in Mouse Ovaries. Biol Reprod. 2015;93:22 pubmed publisher
    ..LATS1, LATS2, and MOB1B were localized to both germ and somatic cells of primordial to antral follicles...
  5. Xiong J, Cui X, Yuan X, Yu X, Sun J, Gong Q. The Hippo/STE20 homolog SIK1 interacts with MOB1 to regulate cell proliferation and cell expansion in Arabidopsis. J Exp Bot. 2016;67:1461-75 pubmed publisher
    ..A yeast two-hybrid screen identified Mob1/Mats homologs MOB1A and MOB1B as SIK1-interacting partners...
  6. Devroe E, Erdjument Bromage H, Tempst P, Silver P. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. J Biol Chem. 2004;279:24444-51 pubmed
    ..In summary, this work identifies a unique class of human kinase-activating subunits that may be functionally analagous to cyclins. ..
  7. Hergovich A, Schmitz D, Hemmings B. The human tumour suppressor LATS1 is activated by human MOB1 at the membrane. Biochem Biophys Res Commun. 2006;345:50-8 pubmed
  8. Yu F, Zhao B, Panupinthu N, Jewell J, Lian I, Wang L, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012;150:780-91 pubmed publisher
    ..Our study identifies extracellular diffusible signals that modulate the Hippo pathway and also establishes the Hippo-YAP pathway as a critical signaling branch downstream of GPCR. ..
  9. Bichsel S, Tamaskovic R, Stegert M, Hemmings B. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. J Biol Chem. 2004;279:35228-35 pubmed
    ..We show that this sequence is autoinhibitory, and our data indicate that the binding of human MOB1 to the N-terminal domain of NDR induces the release of this autoinhibition. ..

More Information


  1. Florindo C, Perdigão J, Fesquet D, Schiebel E, Pines J, Tavares A. Human Mob1 proteins are required for cytokinesis by controlling microtubule stability. J Cell Sci. 2012;125:3085-90 pubmed publisher
    ..Here we report that human Mob1A and Mob1B proteins are involved in the regulation of abscission of the intercellular bridge...
  2. Praskova M, Xia F, Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol. 2008;18:311-21 pubmed publisher
    ..MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MOBKL1A and MOBKL1B polypeptides, homologs of the Drosophila MATS polypeptide, are identified as preferred MST1/MST2 ..
  3. Chow A, Hao Y, Yang X. Molecular characterization of human homologs of yeast MOB1. Int J Cancer. 2010;126:2079-89 pubmed publisher
    ..Our findings provided evidence that hMOB1A and hMOB1B are 2 LATS-binding proteins that may function as tumor suppressors in human cancer cells. ..
  4. Bao Y, Sumita K, Kudo T, Withanage K, Nakagawa K, Ikeda M, et al. Roles of mammalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinases. Genes Cells. 2009;14:1369-81 pubmed publisher
    ..We previously reported that Thr74 of MOB1B is phosphorylated by MST2. Thr12 and Thr35 have also been identified as phosphorylation sites...
  5. Malki K, Uher R, Paya Cano J, Binder E, Rietschel M, Zobel A, et al. Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants. Biol Psychiatry. 2011;69:360-5 pubmed publisher
    ..Convergent evidence from mice and humans suggests a role of the PPM1A in response to noradrenergic but not serotonergic antidepressants. ..