MOB1A

Summary

Gene Symbol: MOB1A
Description: MOB kinase activator 1A
Alias: C2orf6, MATS1, MOB1, MOBK1B, MOBKL1B, Mob4B, MOB kinase activator 1A, MOB1 Mps One Binder homolog A, MOB1, Mps One Binder kinase activator-like 1B, mob1 alpha, mob1 homolog 1B, mps one binder kinase activator-like 1B
Species: human
Products:     MOB1A

Top Publications

  1. Stavridi E, Harris K, Huyen Y, Bothos J, Verwoerd P, Stayrook S, et al. Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways. Structure. 2003;11:1163-70 pubmed
    ..At the molecular level, Mob proteins act as kinase-activating subunits. We cloned a human Mob1 family member, Mob1A, and determined its three-dimensional structure by X-ray crystallography...
  2. Bichsel S, Tamaskovic R, Stegert M, Hemmings B. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. J Biol Chem. 2004;279:35228-35 pubmed
    ..yeast relatives of Homo sapiens NDR, Cbk1, and Dbf2, were shown to interact with Mob2 (Mps one binder 2) and Mob1, respectively. This interaction is required for the activity and biological function of these kinases...
  3. Lai Z, Wei X, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N, et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell. 2005;120:675-85 pubmed
    ..Mats physically associates with Wts to stimulate the catalytic activity of the Wts kinase. A human Mats ortholog (Mats1) can rescue the lethality associated with loss of Mats function in Drosophila...
  4. Bothos J, Tuttle R, Ottey M, Luca F, Halazonetis T. Human LATS1 is a mitotic exit network kinase. Cancer Res. 2005;65:6568-75 pubmed
    ..We report here that human LATS1 interacts with MOB1A, a protein whose homologue in budding yeast associates with kinases involved in mitotic exit...
  5. Hergovich A, Schmitz D, Hemmings B. The human tumour suppressor LATS1 is activated by human MOB1 at the membrane. Biochem Biophys Res Commun. 2006;345:50-8 pubmed
    ..Recently, human LATS1 was reported to interact with human MOB1 (hMOB1), but the activation of LATS1 was not addressed...
  6. Turunen S, von Nandelstadh P, Ohman T, Gucciardo E, Seashore Ludlow B, Martins B, et al. FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. Cell Death Differ. 2019;: pubmed publisher
    ..MST1 activation, as indicated by increased threonine phosphorylation of MST1/2, and the downstream substrate MOB1, in FGFR4-overexpressing T47D and MDA-MB-231 breast cancer cells...
  7. Isfort I, Cyra M, Elges S, Kailayangiri S, Altvater B, Rossig C, et al. SS18-SSX-Dependent YAP/TAZ Signaling in Synovial Sarcoma. Clin Cancer Res. 2019;: pubmed publisher
    ..mediated by an IGF-II/IGF-IR signaling loop leading to dysregulation of the Hippo effectors LATS1 and MOB1. Modulation of YAP/TAZ-TEAD-mediated transcriptional activity by RNAi or verteporfin treatment resulted in ..
  8. Feng X, Arang N, Rigiracciolo D, Lee J, Yeerna H, Wang Z, et al. A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Cancer Cell. 2019;35:457-472.e5 pubmed publisher
    ..Dissection of the underlying mechanism revealed that FAK regulates YAP by tyrosine phosphorylation of MOB1, inhibiting core Hippo signaling...
  9. Ni L, Luo X. Structural and Biochemical Analyses of the Core Components of the Hippo Pathway. Methods Mol Biol. 2019;1893:239-256 pubmed publisher
    ..When Hippo signaling is on, activated MST1/2 partner with SAV1 to phosphorylate and activate the LATS1/2-MOB1 complexes, which in turn phosphorylate and inactivate YAP/TAZ transcription co-activators...

More Information

Publications63

  1. Mana Capelli S, McCollum D. Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling. J Biol Chem. 2018;293:18230-18241 pubmed publisher
    ..autophosphorylation of the kinase in the activation loop to fully activate the kinase, a process facilitated by MOB1. The angiomotin family of proteins (AMOT, AMOTL1, and AMOTL2) bind LATS1/2 and promote its kinase activity and YAP ..
  2. Lin K, Wu G. Isothermal Titration Calorimetry Assays to Measure Binding Affinities In Vitro. Methods Mol Biol. 2019;1893:257-272 pubmed publisher
    ..signal transduction pathway, protein-protein interactions are often explored, because various proteins such as MOB1, NDR1/NDR2, and LATS1/LATS2 are very important members in this complicated signaling pathway...
  3. Han H, Qi R, Zhou J, Ta A, Yang B, Nakaoka H, et al. Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Mol Cell. 2018;72:328-340.e8 pubmed publisher
    ..Mechanistically, PA directly interacts with Hippo components LATS and NF2 to disrupt LATS-MOB1 complex formation and NF2-mediated LATS membrane translocation and activation, respectively...
  4. Xu W, Yang Z, Xie C, Zhu Y, Shu X, Zhang Z, et al. PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis. J Exp Clin Cancer Res. 2018;37:198 pubmed publisher
    ..Mechanistically, PTEN lipid phosphatase inactivation abolished the MOB1-LATS1/2 interaction, decreased YAP phosphorylation and finally promoted YAP nuclear translocation, which enhanced ..
  5. Lee P, Machner M. The Legionella Effector Kinase LegK7 Hijacks the Host Hippo Pathway to Promote Infection. Cell Host Microbe. 2018;24:429-438.e6 pubmed publisher
    ..LegK7, like Hippo/MST1, phosphorylates the scaffolding protein MOB1, which triggers a signaling cascade resulting in the degradation of the transcriptional regulators TAZ and YAP1...
  6. Chen M, Zhang H, Shi Z, Li Y, Zhang X, Gao Z, et al. The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer. J Biol Chem. 2018;293:14455-14469 pubmed publisher
    The mammalian STE20-like protein kinase 1 (MST1)-MOB kinase activator 1 (MOB1) complex has been shown to suppress the oncogenic activity of Yes-associated protein (YAP) in the mammalian Hippo pathway, which is involved in the development ..
  7. Song Z, Han X, Zou H, Zhang B, Ding Y, Xu X, et al. PTEN-GSK3β-MOB1 axis controls neurite outgrowth in vitro and in vivo. Cell Mol Life Sci. 2018;75:4445-4464 pubmed publisher
    Mps One binder 1 (MOB1) is a core component of NDR/LATS kinase and a positive regulator of the Hippo signaling pathway. However, its role in neurite outgrowth still remains to be clarified...
  8. Hergovich A. MOB control: reviewing a conserved family of kinase regulators. Cell Signal. 2011;23:1433-40 pubmed publisher
    ..Loss of dMOB1 resulted in increased cell proliferation and decreased cell death, suggesting that MOB1 acts as tumour suppressor protein...
  9. Xiong S, Lorenzen K, Couzens A, Templeton C, Rajendran D, Mao D, et al. Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment. Structure. 2018;26:1101-1115.e6 pubmed publisher
    ..diverse aspects of cell growth, and are regulated through phosphorylation and association with scaffolds such as MOB1. Here, we report the crystal structure of the human NDR1 kinase domain in its non-phosphorylated state, revealing a ..
  10. Mohamed A, Tremblay A, Murray G, Wackerhage H. The Hippo signal transduction pathway in soft tissue sarcomas. Biochim Biophys Acta. 2015;1856:121-9 pubmed publisher
    ..Several transgenic mouse models of Hippo pathway members (Nf2, Mob1, LATS1 and YAP1 mutants) develop various types of sarcoma...
  11. Hergovich A. The Roles of NDR Protein Kinases in Hippo Signalling. Genes (Basel). 2016;7: pubmed publisher
    ..the core cassette of the Hippo pathway includes the MST1/2 protein kinases, the LATS1/2 protein kinases, and the MOB1 scaffold signal transducer, which together regulate the transcriptional co-activator functions of the proto-..
  12. Cui X, Guo Z, Song L, Wang Y, Cheng Y. NCP1/AtMOB1A Plays Key Roles in Auxin-Mediated Arabidopsis Development. PLoS Genet. 2016;12:e1005923 pubmed publisher
    b>MOB1 protein is a core component of the Hippo signaling pathway in animals where it is involved in controlling tissue growth and tumor suppression...
  13. Sharif A, Hergovich A. The NDR/LATS protein kinases in immunology and cancer biology. Semin Cancer Biol. 2018;48:104-114 pubmed publisher
    ..We also discuss the activation mechanisms of NDR/LATS involving Ste20-like kinases and the MOB1 signal transducer, followed by an overview of NDR/LATS knockout mouse models...
  14. Goto H, Nishio M, To Y, Oishi T, Miyachi Y, Maehama T, et al. Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9. Development. 2018;145: pubmed publisher
    ..Here, we generated tamoxifen-inducible, chondrocyte-specific Mob1a/b-deficient mice and show that hyperactivation of endogenous YAP1/TAZ impairs chondrocyte proliferation and ..
  15. Zheng Y, Liu B, Wang L, Lei H, Pulgar Prieto K, Pan D. Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex. Cell Rep. 2017;21:3612-3623 pubmed publisher
    ..In contrast, autophosphorylation of the Hpo/MST linker at distinct sites is known to recruit Mats/MOB1 to facilitate Hippo signaling...
  16. Gardiner K, Downs L, Berta Antalics A, Santana E, Aguirre G, Genini S. Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerations. BMC Genomics. 2016;17:221 pubmed publisher
    ..mutation-specific changes in the expression of NDR kinases and Hippo signaling members with increased expression of MOB1 and LATS1 in the newly generated hybrid rod/S-cones...
  17. Kim S, Ye S, Rah S, Park B, Wang H, Kim J, et al. RhBMP-2 Activates Hippo Signaling through RASSF1 in Esophageal Cancer Cells. Sci Rep. 2016;6:26821 pubmed publisher
    ..In addition, rhBMP-2 increased MST1, MOB1, and p-YAP protein levels and the RASSF1 binds Mst1 more upon treatment with rhBMP2...
  18. Yan M, Chu L, Qin B, Wang Z, Liu X, Jin C, et al. Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis. Sci Rep. 2015;5:10449 pubmed publisher
    ..Mechanistically, PLK1-mediated phosphorylation protects the binding of Mob1 to NDR1 and subsequent NDR1 activation...
  19. Yan C, Zhang D, Raygoza Garay J, Mwangi M, Bai L. Decoupling of divergent gene regulation by sequence-specific DNA binding factors. Nucleic Acids Res. 2015;43:7292-305 pubmed publisher
    ..Using time-lapse fluorescence microscopy, we carried out an in-depth study of a differentially regulated DGP, PFK26-MOB1. We found that their differential regulation is mainly achieved through two DNA-binding factors, Tbf1 and Mcm1...
  20. Hergovich A. Hippo Signaling in Mitosis: An Updated View in Light of the MEN Pathway. Methods Mol Biol. 2017;1505:265-277 pubmed
    ..of the Hippo pathway are conserved from yeast to man, with the yeast analogs of mammalian MST1/2 (fly Hippo), MOB1 (fly Mats), LATS1/2 (fly Warts), and NDR1/2 (fly Tricornered) functioning as essential components of the mitotic ..
  21. Scarfone I, Piatti S. Asymmetric Localization of Components and Regulators of the Mitotic Exit Network at Spindle Pole Bodies. Methods Mol Biol. 2017;1505:183-193 pubmed
    ..Recruitment to SPBs of the small GTPase Tem1 and the downstream kinases Cdc15 and Mob1/Dbf2 is thought to be essential for Cdc14 activation and mitotic exit, while that of the upstream Tem1 regulators (..
  22. Zhang M, Zhao Y, Zhang Y, Wang D, Gu S, Feng W, et al. LncRNA UCA1 promotes migration and invasion in pancreatic cancer cells via the Hippo pathway. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1770-1782 pubmed publisher
    ..Mechanistically, UCA1 interacted with MOB1, Lats1, and YAP, forming shielding composites...
  23. Vahid S, Thaper D, Gibson K, Bishop J, Zoubeidi A. Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer. Sci Rep. 2016;6:31842 pubmed publisher
    ..of ubiquitinated MST1, the core Hippo kinase, resulting in reduced phosphorylation/activity of LATS1 and MOB1, its downstream effectors...
  24. Joffre C, Dupont N, Hoa L, Gómez V, Pardo R, Gonçalves Pimentel C, et al. The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy. Curr Biol. 2015;25:2479-92 pubmed publisher
    ..Upon studying the activation of STK38 during autophagy induction, we found that STK38 is stimulated in a MOB1- and exocyst-dependent manner...
  25. Xiong J, Cui X, Yuan X, Yu X, Sun J, Gong Q. The Hippo/STE20 homolog SIK1 interacts with MOB1 to regulate cell proliferation and cell expansion in Arabidopsis. J Exp Bot. 2016;67:1461-75 pubmed publisher
    ..In plants, the Mob1/Mats homolog MOB1A has been characterized as a regulator of cell proliferation and sporogenesis...
  26. Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, et al. MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene. 2017;36:4201-4211 pubmed publisher
    ..To investigate MOB1A/B's roles in normal physiology and lung cancer, we generated doxycycline (Dox)-inducible, bronchioalveolar ..
  27. Chen M, Wang M, Xu S, Guo X, Jiang J. Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway. Oncotarget. 2015;6:44466-79 pubmed publisher
    ..1/2 (LATS1/2), together with the adaptor proteins Salvador homologue 1 (SAV1) and MOB kinase activator 1 (MOB1), tightly restricts the activities of homologous oncoproteins Yes-associated protein (YAP) and transcriptional co-..
  28. Dutta S, Mana Capelli S, Paramasivam M, Dasgupta I, Cirka H, Billiar K, et al. TRIP6 inhibits Hippo signaling in response to tension at adherens junctions. EMBO Rep. 2018;19:337-350 pubmed publisher
    ..TRIP6 competes with MOB1 for binding to LATS1/2 thereby blocking MOB1 from recruiting the LATS1/2 activating kinases MST1/2...
  29. Moreno C, Lane W, Pallas D. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. J Biol Chem. 2001;276:24253-60 pubmed
    ..Here we identify a major member of these complexes as class II mMOB1, a mammalian homolog of the yeast protein MOB1, and show that its phosphorylation appears to be regulated by PP2A...
  30. Florindo C, Perdigão J, Fesquet D, Schiebel E, Pines J, Tavares A. Human Mob1 proteins are required for cytokinesis by controlling microtubule stability. J Cell Sci. 2012;125:3085-90 pubmed publisher
    ..Here we report that human Mob1A and Mob1B proteins are involved in the regulation of abscission of the intercellular bridge...
  31. Chung H, Gu M, Buehler E, Macdonald M, Rice C. Seed sequence-matched controls reveal limitations of small interfering RNA knockdown in functional and structural studies of hepatitis C virus NS5A-MOBKL1B interaction. J Virol. 2014;88:11022-33 pubmed publisher
    ..approaches to elucidate host factors involved in HCV nonstructural protein NS5A function and found that MOBKL1B interacts with NS5A...
  32. Suzuki H, Yabuta N, Okada N, Torigata K, Aylon Y, Oren M, et al. Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis. J Cell Sci. 2013;126:4358-68 pubmed publisher
    ..Accordingly, Lats2 overexpression induces p21 degradation, activation of caspase-3 and caspase-9, and apoptosis. These findings describe a novel Lats2-dependent mechanism for induction of cell death in response to severe DNA damage. ..
  33. Praskova M, Xia F, Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol. 2008;18:311-21 pubmed publisher
    ..MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MOBKL1A and MOBKL1B polypeptides, homologs of the Drosophila MATS polypeptide, are identified as preferred MST1/MST2 substrates in ..
  34. Renicke C, Allmann A, Lutz A, Heimerl T, Taxis C. The Mitotic Exit Network Regulates Spindle Pole Body Selection During Sporulation of Saccharomyces cerevisiae. Genetics. 2017;206:919-937 pubmed publisher
    ..Moreover, efficient genome inheritance requires Dbf2/20-Mob1 during a late step in spore maturation...
  35. Hoa L, Kulaberoglu Y, Gundogdu R, Cook D, Mavis M, Gomez M, et al. The characterisation of LATS2 kinase regulation in Hippo-YAP signalling. Cell Signal. 2016;28:488-497 pubmed publisher
    ..Current evidence suggests that the Hippo kinases MST1/2 together with the MOB1 scaffold protein promote the formation of active MOB1/LATS complexes which phosphorylate and thereby inhibit YAP1...
  36. Kulaberoglu Y, Lin K, Holder M, Gai Z, Gomez M, Assefa Shifa B, et al. Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control. Nat Commun. 2017;8:695 pubmed publisher
    ..a core cassette consisting of the Hippo (MST1/2), Warts (LATS1/2), and Tricornered (NDR1/2) kinases together with MOB1 as an important signaling adaptor...
  37. Chow A, Hao Y, Yang X. Molecular characterization of human homologs of yeast MOB1. Int J Cancer. 2010;126:2079-89 pubmed publisher
    ..Our findings provided evidence that hMOB1A and hMOB1B are 2 LATS-binding proteins that may function as tumor suppressors in human cancer cells. ..
  38. Shen J, Su J, Wu D, Zhang F, Fu H, Zhou H, et al. Growth Inhibition Accompanied by MOB1 Upregulation in Human Acute Lymphoid Leukemia Cells by 3-Deazaneplanocin A. Biochem Genet. 2015;53:268-79 pubmed publisher
    ..The expression of Mps one binder kinase activator 1 gene (MOB1) mRNA and protein was determined by RT-PCR and Western blotting, respectively...
  39. Lignitto L, Arcella A, Sepe M, Rinaldi L, Delle Donne R, Gallo A, et al. Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth. Nat Commun. 2013;4:1822 pubmed publisher
    ..These findings identify praja2 as a novel upstream regulator of the Hippo cascade, linking the ubiquitin proteasome system to deregulated glioblastoma growth. ..
  40. Kosaka Y, Mimori K, Tanaka F, Inoue H, Watanabe M, Mori M. Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer. Int J Oncol. 2007;31:333-8 pubmed
    Human Mob as tumor suppressor 1 (MATS1) has been shown to play a crucial role in tumor growth by regulating cell proliferation and apoptosis...
  41. Hirabayashi S, Nakagawa K, Sumita K, Hidaka S, Kawai T, Ikeda M, et al. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. Oncogene. 2008;27:4281-92 pubmed publisher
    ..Okadaic acid (OA), which activates MST2, facilitates the complex formation of MOB1, MST2 and NDR1 in HEK293FT cells. The in vitro biochemical study demonstrates the phosphorylation of MOB1 by MST2...
  42. Morinaka A, Funato Y, Uesugi K, Miki H. Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis. Oncogene. 2011;30:4208-18 pubmed publisher
    ..Collectively, our results show a novel PRX-I function to cause cell death in response to high levels of oxidative stress by activating MST1, which underlies the p53-dependent cytotoxicity caused by anticancer agents. ..
  43. Lobo G, Fulmer D, Guo L, Zuo X, Dang Y, Kim S, et al. The exocyst is required for photoreceptor ciliogenesis and retinal development. J Biol Chem. 2017;292:14814-14826 pubmed publisher
    ..i>exoc5 knockout increased phosphorylation of the regulatory protein Mob1, consistent with Hippo pathway activation...
  44. Ni L, Li S, Yu J, Min J, Brautigam C, Tomchick D, et al. Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. Structure. 2013;21:1757-68 pubmed publisher
    ..We propose that these temporally sensitive functions of RASSFs enable the Hippo pathway to respond to and integrate diverse cellular signals. ..
  45. Rawat S, Creasy C, Peterson J, Chernoff J. The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein. J Biol Chem. 2013;288:8762-71 pubmed publisher
    ..These results suggest that hydrogen peroxide-stimulated Mst1 activates a positive feedback loop to sustain an oxidizing cellular state. ..
  46. Yang W, Han W, Qin A, Wang Z, Xu J, Qian Y. The emerging role of Hippo signaling pathway in regulating osteoclast formation. J Cell Physiol. 2017;: pubmed publisher
    ..is regulated by the Hippo signaling pathway including key regulatory molecules RASSF2, NF2, MST1/2, SAV1, LATS1/2, MOB1, YAP and TAZ...
  47. Kohler R, Schmitz D, Cornils H, Hemmings B, Hergovich A. Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases. Mol Cell Biol. 2010;30:4507-20 pubmed publisher
    ..The human MOB protein family consists of six distinct members (human MOB1A [hMOB1A], -1B, -2, -3A, -3B, and -3C), with hMOB1A/B the best studied due to their putative tumor-suppressive ..
  48. Wilmeth L, Shrestha S, Montaño G, Rashe J, Shuster C. Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. Mol Biol Cell. 2010;21:380-92 pubmed publisher
    ..There are five human Mob1 isoforms, all of which display redundant localization patterns at the spindle poles and kinetochores in early ..
  49. Yuan L, Li Z. [Research advances in the role of the Hippo signaling pathway in pathogenesis of liver cancer]. Zhonghua Gan Zang Bing Za Zhi. 2017;25:797-800 pubmed publisher
    The Hippo signaling pathway consists of four core components in mammals, i.e., Mst1/2, WW45, Mob1, and LATS1/2, which can inhibit the transcriptional coactivator YAP from entering the nucleus, maintain the balance between cell ..
  50. Andrade V, Guerra M, Jardim C, Melo F, Silva W, Ortega J, et al. Nucleoplasmic calcium regulates cell proliferation through legumain. J Hepatol. 2011;55:626-635 pubmed publisher
    ..Increased expression of LGMN may be involved in liver carcinogenesis. ..
  51. Petzold H, Rigoulot S, Zhao C, Chanda B, Sheng X, Zhao M, et al. Identification of new protein-protein and protein-DNA interactions linked with wood formation in Populus trichocarpa. Tree Physiol. 2017;:1-16 pubmed publisher
    ..Selected examples are discussed including a PPI between Mps one binder (MOB1) and a mitogen-activated protein kinase kinase kinase kinase (M4K) that was further characterized by assays ..
  52. Couzens A, Xiong S, Knight J, Mao D, Guettler S, Picaud S, et al. MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway. Mol Cell Proteomics. 2017;16:1098-1110 pubmed publisher
    ..The crystal structures of MOB1A in complex with two favored phosphopeptide sites in MST1 allow for a full description of the MOB1A phosphopeptide-..
  53. Wei X, Shimizu T, Lai Z. Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila. EMBO J. 2007;26:1772-81 pubmed
    ..Our results support a model in which Mats is activated by Hpo through phosphorylation for growth inhibition, and this regulatory mechanism is conserved from flies to mammals. ..
  54. Xiong S, Couzens A, Kean M, Mao D, Guettler S, Kurinov I, et al. Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation. Mol Cell Proteomics. 2017;16:1111-1125 pubmed publisher
    ..Our previous interaction proteomics analysis revealed that beyond associating with MST1 (and MST2), MOB1A and MOB1B can associate in a phosphorylation-dependent manner with at least two other signaling complexes, one ..