MNAT1

Summary

Gene Symbol: MNAT1
Description: MNAT1, CDK activating kinase assembly factor
Alias: CAP35, MAT1, RNF66, TFB3, CDK-activating kinase assembly factor MAT1, CDK7/cyclin-H assembly factor, MNAT CDK-activating kinase assembly factor 1, RING finger protein 66, RING finger protein MAT1, cyclin G1 interacting protein, menage a trois 1 (CAK assembly factor), menage a trois homolog 1, cyclin H assembly factor, menage a trois-like protein 1 cyclin H assembly factor
Species: human
Products:     MNAT1

Top Publications

  1. Rossignol M, Kolb Cheynel I, Egly J. Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH. EMBO J. 1997;16:1628-37 pubmed
    ..Three subunits of TFIIH, cdk7, cyclin H and MAT1, form a ternary complex, cdk-activating kinase (CAK), found either on its own or as part of TFIIH...
  2. Inamoto S, Segil N, Pan Z, Kimura M, Roeder R. The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors. J Biol Chem. 1997;272:29852-8 pubmed
    ..In the present study, a yeast two-hybrid screen with the Oct-1 POU domain as a bait identified MAT1 as a POU domain-binding protein...
  3. Ko L, Shieh S, Chen X, Jayaraman L, Tamai K, Taya Y, et al. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Mol Cell Biol. 1997;17:7220-9 pubmed
    ..Furthermore, we show that p36 and p53 can interact both in vitro and in vivo. These studies reveal a potential mechanism for coupling the regulation of p53 with DNA repair and the basal transcriptional machinery. ..
  4. Noguchi E, Noguchi C, McDonald W, Yates J, Russell P. Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol Cell Biol. 2004;24:8342-55 pubmed
    Swi1 is required for programmed pausing of replication forks near the mat1 locus in the fission yeast Schizosaccharomyces pombe. This fork pausing is required to initiate a recombination event that switches mating type...
  5. Moore G, Mack B, Beltz S, Puel O. Genome sequence of an aflatoxigenic pathogen of Argentinian peanut, Aspergillus arachidicola. BMC Genomics. 2018;19:189 pubmed publisher
    ..flavus mating-type idiomorph sequences to this strain revealed the presence of a single mating-type (MAT1-1) idiomorph. Based on A. arachidicola morphological, genetic and chemotype similarities with A. flavus and A...
  6. Rehner S, Kepler R. Species limits, phylogeography and reproductive mode in the Metarhizium anisopliae complex. J Invertebr Pathol. 2017;148:60-66 pubmed publisher
    ..species has yet been confirmed to produce a sexual state, we demonstrate the mutually exclusive incidence of the MAT1 and MAT2 mating type idiomorphs among individuals in all PARB species...
  7. Kanzi A, Steenkamp E, van der Merwe N, Wingfield B. The mating system of the Eucalyptus canker pathogen Chrysoporthe austroafricana and closely related species. Fungal Genet Biol. 2019;123:41-52 pubmed publisher
    ..austroafricana isolates and its sibling species, C. cubensis and C. deuterocubensis. A unique MAT1-2 idiomorph containing a truncated MAT1-1-1 gene, and a MAT1-1-2 gene, was identified in one isolate of C...
  8. Nel W, Duong T, Wingfield M, Wingfield B, Hammerbacher A, De Beer Z. Heterothallism revealed in the root rot fungi Berkeleyomyces basicola and B. rouxiae. Fungal Biol. 2018;122:1031-1040 pubmed publisher
    ..the complete characterization of the MATlocus, revealing that it has a typical heterothallic mating system with the MAT1-1andMAT1-2 idiomorphs occurring in different isolates...
  9. Metin B, Döğen A, Yildirim E, de Hoog G, Heitman J, Ilkit M. Mating type (MAT) locus and possible sexuality of the opportunistic pathogen Exophiala dermatitidis. Fungal Genet Biol. 2019;124:29-38 pubmed publisher
    ..dermatitidis genome harbors a high mobility group (HMG) domain gene (MAT1-2-1) in the vicinity of the SLA2 and APN2 genes. The MAT loci of 74 E...

More Information

Publications142 found, 100 shown here

  1. Zhou S, Lu J, Li Y, Chen C, Cai Y, Tan G, et al. MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance. J Exp Clin Cancer Res. 2018;37:284 pubmed publisher
    b>MNAT1 (menage a trois 1, MAT1), a cyclin-dependent kinase-activating kinase (CAK) complex, high expresses in various cancers and is involved in cancer pathogenesis...
  2. Robinson A, Natvig D. Diverse members of the Xylariales lack canonical mating-type regions. Fungal Genet Biol. 2019;122:47-52 pubmed publisher
    ..Xylariales (representing 15 genera) available in public databases indicated that genes typically associated with MAT1-1 (mat A) or MAT1-2 (mat a) mating types are absent or have diverged greatly relative to counterparts in other ..
  3. Olukayode T, Quime B, Shen Y, Yanoria M, Zhang S, Yang J, et al. Dynamic insertion of Pot3 in AvrPib prevailing in a field rice blast population in the Philippines led to the high virulence frequency against the resistance gene Pib in rice. Phytopathology. 2018;: pubmed publisher
    ..Both mating types MAT1-1 and MAT1-2 were identified in the population in Bohol and the latter one appeared dominant...
  4. Abate D, De Miccolis Angelini R, Rotolo C, Pollastro S, Faretra F. Mating system in the brown rot pathogens Monilinia fructicola, Monilinia laxa and Monilinia fructigena. Phytopathology. 2018;: pubmed publisher
    ..We showed that single isolates carry only one of two opposite idiomorphs at the MAT1 locus consistent with a heterothallic mating system for all three species...
  5. Kosanke S, Hamann L, Kupsch C, Moreno Garcia S, Chopra A, Gräser Y. Unequal distribution of the mating type (MAT) locus idiomorphs in dermatophyte species. Fungal Genet Biol. 2018;118:45-53 pubmed publisher
    ..We identified for the first time the MAT locus idiomorphs of the dermatophyte species Microsporum audouinii (MAT1-2), M. ferrugineum (MAT1-2), Trichophyton schoenleinii (MAT1-2), T. bullosum (MAT1-1), T. quinckeanum (MAT1-1), T...
  6. Zhou Z, Wu J, Wang M, Zhang J. ABC protein CgABCF2 is required for asexual and sexual development, appressorial formation and plant infection in Colletotrichum gloeosporioides. Microb Pathog. 2017;110:85-92 pubmed publisher
    ..In addition, CgABCF2 mediated sexual development through the positive regulation of the gene MAT1-2-1 expression...
  7. Young C, Bock C, Charlton N, Mattupalli C, Krom N, Bowen J, et al. Evidence for sexual reproduction: identification, frequency and spatial distribution of Venturia effusa (pecan scab) mating type idiomorphs. Phytopathology. 2018;: pubmed publisher
    ..inaequalis. Using the mating type idiomorphs from V. inaequalis we identified a single mating-type gene, MAT1-1-1, in a draft genome of V. effusa...
  8. Wilken P, Steenkamp E, van der Nest M, Wingfield M, de Beer Z, Wingfield B. Unexpected placement of the MAT1-1-2 gene in the MAT1-2 idiomorph of Thielaviopsis. Fungal Genet Biol. 2018;113:32-41 pubmed publisher
    Sexual reproduction in the Ascomycota is controlled by genes encoded at the mating-type or MAT1 locus...
  9. Laraba I, Boureghda H, Abdallah N, Bouaicha O, Obanor F, Moretti A, et al. Population genetic structure and mycotoxin potential of the wheat crown rot and head blight pathogen Fusarium culmorum in Algeria. Fungal Genet Biol. 2017;103:34-41 pubmed publisher
    ..A PCR assay for MAT idiomorph revealed that MAT1-1 and MAT1-2 strains were segregating in nearly equal proportions, except within Algeria where two-thirds of the ..
  10. Du X, Zhao Q, Xia E, Gao L, Richard F, Yang Z. Mixed-reproductive strategies, competitive mating-type distribution and life cycle of fourteen black morel species. Sci Rep. 2017;7:1493 pubmed publisher
    ..Furthermore, MAT1-1-1 was detected significantly more commonly than MAT1-2-1 in natural populations, which strongly suggested a ..
  11. Yin Z, Ke X, Li Z, Chen J, Gao X, Huang L. Unconventional Recombination in the Mating Type Locus of Heterothallic Apple Canker Pathogen Valsa mali. G3 (Bethesda). 2017;7:1259-1265 pubmed publisher
    ..in filamentous ascomycetes is controlled by the mating type (MAT) locus, including two idiomorphs MAT1-1 and MAT1-2 Understanding the MAT locus can provide clues for unveiling the sexual development ..
  12. Olarte R, Horn B, Singh R, Carbone I. Sexual recombination in Aspergillus tubingensis. Mycologia. 2015;107:307-12 pubmed publisher
    ..Progeny were obtained from six crosses involving five MAT1-1 strains and two MAT1-2 strains...
  13. Losada L, Sugui J, Eckhaus M, Chang Y, Mounaud S, Figat A, et al. Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence. PLoS Pathog. 2015;11:e1004834 pubmed publisher
    ..The pair was made isogenic by 9 successive backcross cycles of the foundational strain AFB62 (MAT1-1) with a highly fertile (MAT1-2) progeny...
  14. Moore G, Mack B, Beltz S. Genomic sequence of the aflatoxigenic filamentous fungus Aspergillus nomius. BMC Genomics. 2015;16:551 pubmed publisher
    ..This strain contains a single mating-type idiomorph designated as MAT1-1. This study provides a preliminary analysis of the A. nomius genome...
  15. Lopes A, Linaldeddu B, Phillips A, Alves A. Mating type gene analyses in the genus Diplodia: From cryptic sex to cryptic species. Fungal Biol. 2018;122:629-638 pubmed publisher
    ..A PCR-based mating type diagnostic assay was developed that allowed amplification and sequencing of the MAT1-1-1 and MAT1-2-1 genes, and determination of the mating strategies used by different species...
  16. Jiménez Trejo F, Coronado Mares I, Boeta M, González Santoyo I, Vigueras Villaseñor R, Arriaga Canon C, et al. Identification of serotoninergic system components in stallion sperm. Histol Histopathol. 2018;33:951-958 pubmed publisher
    ..Our results suggest that serotoninergic system is present in stallion sperm, which could be a pharmacological target to increase the conception rates in domestic horses. ..
  17. Gnatt A, Cramer P, Fu J, Bushnell D, Kornberg R. Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution. Science. 2001;292:1876-82 pubmed
    ..Protein-nucleic acid contacts help explain DNA and RNA strand separation, the specificity of RNA synthesis, "abortive cycling" during transcription initiation, and RNA and DNA translocation during transcription elongation. ..
  18. Kano R, Tsui C, Hamelin R, Anzawa K, Mochizuki T, Nishimoto K, et al. The MAT1-1:MAT1-2 ratio of Sporothrix globosa isolates in Japan. Mycopathologia. 2015;179:81-6 pubmed publisher
    ..biology of pathogenic species in the Sporothrix schenckii complex, we characterized the partial mating type (MAT1-1) loci of Sporothrix schenckii, as well as the S. globosa MAT1-1-1 gene, which encoded 262 amino acid sequences...
  19. Wilson A, Godlonton T, van der Nest M, Wilken P, Wingfield M, Wingfield B. Unisexual reproduction in Huntiella moniliformis. Fungal Genet Biol. 2015;80:1-9 pubmed publisher
    ..was shown to exhibit a typically heterothallic sexual reproductive cycle, with isolates possessing either the MAT1-1 or MAT1-2 idiomorph. This was in contrast to the homothallism via unisexual reproduction that was shown in H...
  20. Putman A, Tredway L, Carbone I. Characterization and distribution of mating-type genes of the turfgrass pathogen Sclerotinia homoeocarpa on a global scale. Fungal Genet Biol. 2015;81:25-40 pubmed publisher
    ..strains and three of four historical type strains; (2) putatively heterothallic with a deleted putative gene in the MAT1-2 idiomorph, as detected in strains from two recently-collected populations in the United Kingdom that show more ..
  21. Onaga G, Wydra K, Koopmann B, Séré Y, von Tiedemann A. Population Structure, Pathogenicity, and Mating Type Distribution of Magnaporthe oryzae Isolates from East Africa. Phytopathology. 2015;105:1137-45 pubmed publisher
    ..001) departure from panmixia (IA and rd=0). Both MAT1-1 and MAT1-2 were detected. However, MAT1-1 was more prevalent than MAT1-2...
  22. Kusai N, Azmi M, Zainudin N, Yusof M, Razak A. Morphological and molecular characterization, sexual reproduction, and pathogenicity of Setosphaeria rostrata isolates from rice leaf spot. Mycologia. 2016;108:905-914 pubmed
    ..Mating-type analyses indicated that three isolates carried the MAT1-1 allele, and the other 42 isolates carried MAT1-2 After isolates with opposite mating types were crossed on Sach's ..
  23. Wey T, Schlegel M, Stroheker S, Gross A. MAT--gene structure and mating behavior of Hymenoscyphus fraxineus and Hymenoscyphus albidus. Fungal Genet Biol. 2016;87:54-63 pubmed publisher
    ..and report the finding of three additional genes within this region; the as yet unobserved typical mating type gene MAT1-1-1, a DNA polymerase zeta catalytic subunit-like gene and a pre-mRNA-splicing factor SLU7-like gene...
  24. de la Varga H, Murat C. Identification and In Situ Distribution of a Fungal Gene Marker: The Mating Type Genes of the Black Truffle. Methods Mol Biol. 2016;1399:141-9 pubmed publisher
    ..The black Périgord truffle, Tuber melanosporum, is a heterothallic species and the mating type genes (MAT1-1 and M1T1-2) have been characterized. In this context, the unraveling of the T...
  25. Rafiei V, Banihashemi Z, Bautista Jalon L, Jimenez Gasco M, Turgeon G, Milgroom M. Population genetics of Verticillium dahliae in Iran based on microsatellite and SNP markers. Phytopathology. 2018;: pubmed publisher
    ..The mating type of all isolates was MAT1-2...
  26. Jagadeesh D, Prasanna Kumar M, Devaki N. Population analysis of Magnaporthe oryzae by using endogenous repetitive DNA sequences and mating-type alleles in different districts of Karnataka, India. J Appl Genet. 2018;59:365-375 pubmed publisher
    ..oryzae from rice in different districts of Karnataka were examined for identifying sexual mating alleles MAT1, MAT2 and understanding the genetic diversity based on DNA fingerprint of pot2, an inverted repeat transposon...
  27. Singh G, Dal Grande F, Werth S, Scheidegger C. Long-term consequences of disturbances on reproductive strategies of the rare epiphytic lichen Lobaria pulmonaria: clonality a gift and a curse. FEMS Microbiol Ecol. 2015;91:1-11 pubmed publisher
    ..pulmonaria-specific MAT1-1 and MAT1-2 markers to analyse the frequency and distribution of mating types of 889 individuals...
  28. Deshmukh A, Mitra P, Maruthi M. Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii. Sci Rep. 2016;6:35288 pubmed publisher
    Cyclin-dependent kinase 7 in conjunction with CyclinH and Mat1 activates cell cycle CDKs and is a part of the general transcription factor TFIIH...
  29. Fogelqvist J, Tzelepis G, Bejai S, Ilbäck J, Schwelm A, Dixelius C. Analysis of the hybrid genomes of two field isolates of the soil-borne fungal species Verticillium longisporum. BMC Genomics. 2018;19:14 pubmed publisher
    ..dahliae. Presence of the mating-type genes MAT1-1-1 and MAT1-2-1 in the V. longisporum genomes were confirmed. However, the MAT genes in V. dahliae, V...
  30. King R, Brown N, Urban M, Hammond Kosack K. Inter-genome comparison of the Quorn fungus Fusarium venenatum and the closely related plant infecting pathogen Fusarium graminearum. BMC Genomics. 2018;19:269 pubmed publisher
    ..Unlike homothallic F. graminearum, heterothallic F. venenatum possessed the MAT1-1 type locus, but lacked the MAT1-2 locus. The F...
  31. Yin M, Duong T, Wingfield M, Zhou X, de Beer Z. Taxonomy and phylogeny of the Leptographium procerum complex, including Leptographium sinense sp. nov. and Leptographium longiconidiophorum sp. nov. Antonie Van Leeuwenhoek. 2015;107:547-63 pubmed publisher
    ..regions (ITS2-LSU, actin, β-tubulin, calmodulin, translation elongation factor 1-α, and the mating type genes MAT1-1-3 and MAT1-2-1) distinguished between nine species in the complex. These included L. procerum, L. bhutanense, L...
  32. Yu J, Sun W, Yu M, Yin X, Meng X, Zhao J, et al. Characterization of mating-type loci in rice false smut fungus Villosiclava virens. FEMS Microbiol Lett. 2015;362: pubmed publisher
    ..phytopathogenic fungus exists in heterothallic form, and mating compatibility is regulated by mating-type locus 1 (MAT1). However, the MAT1 locus structure remains unknown. The MAT1-1 and MAT1-2 idiomorphs of V...
  33. Bock C, Young C, Stevenson K, Charlton N. Fine scale population genetic structure and within tree distribution of mating types of Venturia effusa, cause of pecan scab in the U.S.A. Phytopathology. 2018;: pubmed publisher
    ..05). Overall, the MAT1-1-1 and MAT1-2-1 idiomorphs were at equilibrium (73:92), and in most populations, subpopulations and sub-..
  34. Teixeira M, Rodrigues A, Tsui C, de Almeida L, Van Diepeningen A, van den Ende B, et al. Asexual propagation of a virulent clone complex in a human and feline outbreak of sporotrichosis. Eukaryot Cell. 2015;14:158-69 pubmed publisher
    ..Our analysis revealed the presence of a MAT1-1 locus in S. schenckii while a MAT1-2 locus was found in S...
  35. Vaghefi N, Ades P, Hay F, Pethybridge S, Ford R, Taylor P. Identification of the MAT1 locus in Stagonosporopsis tanaceti, and exploring its potential for sexual reproduction in Australian pyrethrum fields. Fungal Biol. 2015;119:408-19 pubmed publisher
    ..chrysanthemi and S. inoxydabilis, a sexual state has not been observed for S. tanaceti. The MAT1 locus in S...
  36. Lozano Sepulveda S, Bautista Osorio E, Merino Mascorro J, Varela Rey M, Muñoz Espinosa L, Cordero Pérez P, et al. S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells. World J Gastroenterol. 2016;22:3746-57 pubmed publisher
    ..A likely mechanism(s) by which SAM diminish HCV expression could involve modulating antioxidant enzymes, restoring biosynthesis of glutathione and switching MAT1/MAT2 turnover in HCV expressing cells.
  37. Lee D, Roux J, Wingfield B, Wingfield M. Non-Mendelian segregation influences the infection biology and genetic structure of the African tree pathogen Ceratocystis albifundus. Fungal Biol. 2018;122:222-230 pubmed publisher
    ..Self-sterile isolates lack the MAT1-2-1 gene and have reduced fitness such as slower growth and reduced pathogenicity, relative to self-fertile ..
  38. Yilmaz N, Hagen F, Meis J, Houbraken J, Samson R. Discovery of a sexual cycle in Talaromyces amestolkiae. Mycologia. 2016;108:70-9 pubmed publisher
    ..003372). The distribution of MAT1-1 and MAT1-2 genes in the progeny showed a close to 1:1 ratio...
  39. Aylward J, Steenkamp E, Dreyer L, Roets F, Wingfield M, Wingfield B. Genetic basis for high population diversity in Protea-associated Knoxdaviesia. Fungal Genet Biol. 2016;96:47-57 pubmed publisher
    ..that this diversity is the result of outcrossing driven by a heterothallic mating system and sought to describe the MAT1 loci of both species...
  40. Valero Jiménez C, Faino L, Spring In t Veld D, Smit S, Zwaan B, van Kan J. Comparative genomics of Beauveria bassiana: uncovering signatures of virulence against mosquitoes. BMC Genomics. 2016;17:986 pubmed
    ..Mating type gene analysis revealed the presence of either the MAT1-1-1 or the MAT1-2-1 gene. Moreover, a putative new MAT gene (MAT1-2-8) was detected in the MAT1-2 locus...
  41. Polat İ, Baysal O, Mercati F, Gumrukcu E, Sülü G, Kitapcı A, et al. Characterization of Botrytis cinerea isolates collected on pepper in Southern Turkey by using molecular markers, fungicide resistance genes and virulence assay. Infect Genet Evol. 2018;60:151-159 pubmed publisher
    ..Mating types were also determined by PCR assays using primer specific for MAT1-1 alpha gene (MAT1-1-1) and MAT1-2 HMG (MAT1-2-1) of B. cinerea...
  42. Zamani Ahmadmahmudi M, Najafi A, Nassiri S. Reconstruction of canine diffuse large B-cell lymphoma gene regulatory network: detection of functional modules and hub genes. J Comp Pathol. 2015;152:119-30 pubmed publisher
    ..Moreover, bioinformatics analysis showed E2F1, E2F4, PTEN, CDKN1A, PCNA, DKC1, MNAT1, NDUFB4, ATP5J, PRKDC, BRCA1, MYCN, RFC4 and POLA1 as the most important hub genes...
  43. Videira S, Groenewald J, Verkley G, Braun U, Crous P. The rise of Ramularia from the Mycosphaerella labyrinth. Fungal Biol. 2015;119:823-43 pubmed publisher
    ..A parsimony analysis was also separately performed with mating-type gene sequences (MAT1-1-1 and MAT1-2-1) and the resulting tree topologies were in accordance with that of the multigene analysis...
  44. Li Y, Jin G, Wang H, Liu H, Qian J, Gu S, et al. Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population. Lung Cancer. 2007;58:171-83 pubmed
    ..Recent observations reveal that the components of CAK: Cdk7, MAT1 and cyclin H, may play important roles in cell cycle control, transcriptional control, and DNA repairing process, ..
  45. Varga J, Szigeti G, Baranyi N, Kocsubé S, O Gorman C, Dyer P. Aspergillus: sex and recombination. Mycopathologia. 2014;178:349-62 pubmed publisher
    ..Knowledge of MAT gene presence has then successfully been applied to induce sexual reproduction between MAT1-1 and MAT1-2 isolates of certain supposedly asexual aspergilli...
  46. Kozakova L, Vondrova L, Stejskal K, Charalabous P, Kolesar P, Lehmann A, et al. The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex. Cell Cycle. 2015;14:920-30 pubmed publisher
    ..These results suggest that MAGEA1 functions as a co-factor of TRIM31 ubiquitin-ligase and that the TRIM31-MAGEA1-NSE4 complex may have evolved from an ancestral NSE1-NSE3-NSE4 complex. ..
  47. Hutchinson M, Powell A, Tsang A, O Toole N, Berka R, Barry K, et al. Genetics of mating in members of the Chaetomiaceae as revealed by experimental and genomic characterization of reproduction in Myceliophthora heterothallica. Fungal Genet Biol. 2016;86:9-19 pubmed publisher
    ..to those of other members of the Sordariales, except for the presence of a truncated version of the mat A-1 (MAT1-1-1) gene in mating-type a (MAT1-2) strains. In M...
  48. Aprelikova O, Xiong Y, Liu E. Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase. J Biol Chem. 1995;270:18195-7 pubmed
    ..These findings suggest that a general mechanism of CDK inhibitor function is to block the phosphorylation of CDK enzymes by CDK-activating kinase. ..
  49. Hiruma J, Okubo M, Kano R, Kumagawa M, Hiruma M, Hasegawa A, et al. Mating Type Gene (MAT) and Itraconazole Susceptibility of Trichophyton tonsurans Strains Isolated in Japan. Mycopathologia. 2016;181:441-4 pubmed publisher
    ..PCR analysis proved that all 60 strains contained the MAT1-1 allele, while none contained the MAT1-2 allele...
  50. Song X, Wang S, Hong X, Li X, Zhao X, Huai C, et al. Single nucleotide polymorphisms of nucleotide excision repair pathway are significantly associated with outcomes of platinum-based chemotherapy in lung cancer. Sci Rep. 2017;7:11785 pubmed publisher
    ..XPA, ERCC6 and POLE were significantly associated with progression free survival, SNPs in GTF2H4, ERCC6, GTF2HA, MAT1, POLD1 were significantly associated with overall survival...
  51. Wang Y, Xu F, Hall F. The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor. FEBS Lett. 2000;484:17-21 pubmed
    b>MAT1 (ménage à trois1) functions as an assembly/targeting factor of CAK (cyclin-dependent kinase-activating kinase)...
  52. Robbins J, Absalon S, Streva V, Dvorin J. The Malaria Parasite Cyclin H Homolog PfCyc1 Is Required for Efficient Cytokinesis in Blood-Stage Plasmodium falciparum. MBio. 2017;8: pubmed publisher
    ..We show that PfCyc1 forms a complex in the parasite with PfMRK and the P. falciparum MAT1 homolog. PfCyc1 is essential and nonredundant in blood-stage P...
  53. Grubisha L, Cotty P. Genetic Analysis of the Aspergillus flavus Vegetative Compatibility Group to Which a Biological Control Agent That Limits Aflatoxin Contamination in U.S. Crops Belongs. Appl Environ Microbiol. 2015;81:5889-99 pubmed publisher
    ..All YV36 isolates carried the SNP in aflC that prevents aflatoxin biosynthesis and the mat1-2 idiomorph at the mating-type locus...
  54. Ortega Beltran A, Grubisha L, Callicott K, Cotty P. The vegetative compatibility group to which the US biocontrol agent Aspergillus flavus AF36 belongs is also endemic to Mexico. J Appl Microbiol. 2016;120:986-98 pubmed publisher
    ..Results revealed that 59 (1·6%) isolates belong to VCG YV36. All 59 isolates had the MAT1-2 idiomorph at the mating-type locus and the single nucleotide polymorphism in the polyketide synthase gene that ..
  55. Nag R, Niggli S, Sousa Guimarães S, Vazquez Pianzola P, Suter B. Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase. Development. 2018;145: pubmed publisher
    ..CAK) complex, an activator of mitotic Cdk1, suggesting that Mms19 functions in mitosis to allow CAK (Cdk7/Cyclin H/Mat1) to become fully active as a Cdk1-activating kinase...
  56. Vandel L, Kouzarides T. Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase. EMBO J. 1999;18:4280-91 pubmed
    ..These results suggest that TFIIH-mediated phosphorylation of E2F-1 plays a role in triggering E2F-1 degradation during S phase. ..
  57. Su C, Fan M, Lu L, Li P. Effects of silencing MTA1 gene by RNA interference on invasion and metastasis of endometrial carcinoma. Eur J Gynaecol Oncol. 2016;37:59-62 pubmed
    The study aimed at the silence effect of MAT1 gene and proteins in Ishikawa cell of human endometrial carcinoma cell line through RNAi mediated by siRNA and also discussed the effect of MTA1 gene silence on the invasion and metastasis of ..
  58. Le Goff P, Montano M, Schodin D, Katzenellenbogen B. Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity. J Biol Chem. 1994;269:4458-66 pubmed
    ..Our studies identify several serines in the NH2-terminal portion of the human ER as being major hormone-regulated phosphorylation sites.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  59. Lou S, Liu G, Shimada H, Yang X, He Q, Wu L. The lost intrinsic fragmentation of MAT1 protein during granulopoiesis promotes the growth and metastasis of leukemic myeloblasts. Stem Cells. 2013;31:1942-53 pubmed publisher
    b>MAT1, an assembly factor and targeting subunit of both cyclin-dependent kinase-activating kinase (CAK) and general transcription factor IIH (TFIIH) kinase, regulates cell cycle and transcription...
  60. Edwards J, Auer D, de Alwis S, Summerell B, Aoki T, Proctor R, et al. Fusarium agapanthi sp. nov., a novel bikaverin and fusarubin-producing leaf and stem spot pathogen of Agapanthus praecox (African lily) from Australia and Italy. Mycologia. 2016;108:981-992 pubmed
    ..Results indicated that they possessed MAT1-2 and MAT1-1 idiomorphs, respectively, indicating that this species might be heterothallic...
  61. Meng J, Wang L, Wang J, Zhao X, Cheng J, Yu W, et al. METHIONINE ADENOSYLTRANSFERASE4 Mediates DNA and Histone Methylation. Plant Physiol. 2018;177:652-670 pubmed publisher
    ..b>MAT1, 2, and 4 proteins exhibited nearly equal activity in an in vitro assay, whereas MAT3 exhibited higher activity...
  62. Houbraken J, Weig M, Groß U, Meijer M, Bader O. Aspergillus oerlinghausenensis, a new mould species closely related to A. fumigatus. FEMS Microbiol Lett. 2016;363: pubmed publisher
    ..Furthermore, A. oerlinghausenensis is protoheterothallic as only the MAT1-1 idiomorph was detected, while A. fischeri is homothallic. The species differs from A...
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    ..derived from these species and from a Tuber borchii expressed sequence tag (EST) showing similarity to the mat1 gene of Alternaria brassicicola, we embarked on a chromosome-walking procedure to sequence the complete MAT region ..
  64. Robicheau B, Bunbury Blanchette A, LaButti K, Grigoriev I, Walker A. The homothallic mating-type locus of the conifer needle endophyte Phialocephala scopiformis DAOMC 229536 (order Helotiales). Fungal Biol. 2017;121:1011-1024 pubmed publisher
    ..Our results: (1) show a homothallic gene arrangement for P. scopiformis [MAT1-1-1, MAT1-2-1, and MAT1-1-3 genes are present], (2) increase the genomic survey of homothallism within ..
  65. Moore G, Mack B, Beltz S. Draft Genome Sequences of Two Closely Related Aflatoxigenic Aspergillus Species Obtained from the Ivory Coast. Genome Biol Evol. 2015;8:729-32 pubmed publisher
    ..Our findings also showed that the A. ochraceoroseus Type strain contains a single MAT1-1 gene, while the Type strain of A...
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    ..The CAK complex, which is also found free in the cell, is composed of cdk7, cyclin H, and MAT1. In the present work, we found that the C terminus of MAT1 binds to the cdk7 x cyclin H complex and activates the ..
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    ..here MGT1 are shown to be diploid, based on a consistent finding of heterozygosity and the presence of both MAT1 and MAT2 mating-type loci. In single locus phylogenies, nuclear intergenic alleles of M...
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    ..e., Ssl1, Tfb4, and Tfb2, in the DNA translocase subunit Ssl2, and in the kinase module subunit Tfb3. Our results are consistent with previously predicted roles for the Tfb2 Hub, Ssl2 Lock, and Tfb3 Latch regions, ..
  70. Bazafkan H, Dattenböck C, Stappler E, Beier S, Schmoll M. Interrelationships of VEL1 and ENV1 in light response and development in Trichoderma reesei. PLoS ONE. 2017;12:e0175946 pubmed publisher
    ..Female sterility of Δvel1 was rescued by deletion of env1 in darkness in MAT1-1, indicating a block of sexual development by ENV1 in darkness that is balanced by VEL1 in the wild-type...
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    ..Cdk7-AS-cyclin H-Mat1 phosphorylates approximately 10-15 endogenous polypeptides in nuclear extracts...
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    ..militaris. Interspecies functional convergence was evident that MAT1-1 and MAT1-2-1 null mutants were sterile and lost the ability to produce stromata in outcrosses with the opposite ..
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    ..the function of mating type (MAT) genes, single-gene deletion mutants were generated in both genes of the MAT1-1 locus and both genes of the MAT1-2 locus...
  74. Moore G, Mack B, Beltz S, Gilbert M. Draft Genome Sequence of an Aflatoxigenic Aspergillus Species, A. bombycis. Genome Biol Evol. 2016;8:3297-3300 pubmed
    ..Our findings also showed that the A. bombycis Type strain contains a single MAT1-2 gene indicating that this species is likely heterothallic (self-infertile)...
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    ..Collectively, these unexpected observations indicate that CDK4-activating kinase(s) should be reconsidered. ..
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    ..Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcription. We discuss evidence that suggests involvement of TFIIH and/or P-TEFb. ..
  78. Chen D, Riedl T, Washbrook E, Pace P, Coombes R, Egly J, et al. Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7. Mol Cell. 2000;6:127-37 pubmed
    ..These findings are suggestive of a novel mechanism by which nuclear receptor activity can be regulated by ligand-dependent recruitment of modifying activities, such as kinases. ..
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  80. Wang J, Barsky L, Davicioni E, Weinberg K, Triche T, Zhang X, et al. Retinoic acid induces leukemia cell G1 arrest and transition into differentiation by inhibiting cyclin-dependent kinase-activating kinase binding and phosphorylation of PML/RARalpha. FASEB J. 2006;20:2142-4 pubmed
    ..found that ATRA-induced cell differentiation accompanies ubiquitination-proteolysis of ménage à trois 1 (MAT1), an assembly factor and targeting subunit of cyclin-dependent kinase (CDK)-activating kinase (CAK) that regulates ..
  81. Ramos Y, Portal O, Lysøe E, Meyling N, Klingen I. Diversity and abundance of Beauveria bassiana in soils, stink bugs and plant tissues of common bean from organic and conventional fields. J Invertebr Pathol. 2017;150:114-120 pubmed publisher
    ..Mating type PCR assays revealed that mating type distribution was skewed, with MAT1/MAT2 proportion of 146/4, indicating limited potential for recombination...
  82. Zheng F, Cao Y, Wang L, Lv X, Meng X, Zhang W, et al. The mating type locus protein MAT1-2-1 of Trichoderma reesei interacts with Xyr1 and regulates cellulase gene expression in response to light. Sci Rep. 2017;7:17346 pubmed publisher
    ..Here, we identified the mating type locus protein MAT1-2-1 as an interacting partner for the key transcriptional activator Xyr1 of T. reesei cellulase genes...
  83. Wang Q, Li M, Zhang X, Huang H, Huang J, Ke J, et al. Upregulation of CDK7 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis. Exp Mol Pathol. 2016;100:514-21 pubmed publisher
    ..as a component of CDK activating kinase (CAK) complex, the complex was composed of CDK7, Cyclin H and RING finger protein Mat1 that contribute to cell cycle progression by phosphorylating other CDKs...
  84. Wang Q, Wang S, Xiong C, James T, Zhang X. Mating-type genes of the anamorphic fungus Ulocladium botrytis affect both asexual sporulation and sexual reproduction. Sci Rep. 2017;7:7932 pubmed publisher
    ..However, Ulocladium strains were shown to possess both MAT1-1-1 and MAT1-2-1 genes as observed in homothallic filamentous Ascomycetes. Here, we demonstrate that the U...
  85. Yu Y, Amich J, Will C, Eagle C, Dyer P, Krappmann S. The novel Aspergillus fumigatus MAT1-2-4 mating-type gene is required for mating and cleistothecia formation. Fungal Genet Biol. 2017;108:1-12 pubmed publisher
    ..In the human pathogen Aspergillus fumigatus sexual identity has previously been shown to be determined by MAT1-1-1 or MAT1-2-1 genes which act as transcriptional regulators and are present within idiomorphs found at the MAT ..
  86. García Martínez L, Mavankal G, Neveu J, Lane W, Ivanov D, Gaynor R. Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription. EMBO J. 1997;16:2836-50 pubmed
    ..These results define a cellular kinase complex whose activity is modulated by Tat to result in activation of HIV-1 trancription. ..
  87. Zhou M, Halanski M, Radonovich M, Kashanchi F, Peng J, Price D, et al. Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription. Mol Cell Biol. 2000;20:5077-86 pubmed
    ..These studies suggest that the ability of Tat to increase transcriptional elongation may be due to its ability to modify the substrate specificity of the CDK9 complex. ..
  88. Fu Z, Larson K, Chitta R, Parker S, Turk B, Lawrence M, et al. Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. Mol Cell Biol. 2006;26:8639-54 pubmed
    ..kinase CCRK (cell cycle-related kinase) is an activating T157 kinase for MRK, whereas active CDK7/cyclin H/MAT1 complexes phosphorylate CDK2 but not MRK...
  89. Wu X, Spitz M, Lee J, Lippman S, Ye Y, Yang H, et al. Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants. Cancer Prev Res (Phila). 2009;2:617-24 pubmed publisher
    ..Furthermore, this study underscores the importance of incorporating germ-line genetic variation data with clinical and risk factor data in constructing prediction models for clinical outcomes. ..
  90. Luo J, Cimermancic P, Viswanath S, Ebmeier C, Kim B, Dehecq M, et al. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Mol Cell. 2015;59:794-806 pubmed publisher
    ..We also reveal the structural basis for defects in patients with xeroderma pigmentosum and trichothiodystrophy, with mutations found at the interface between the p62 Anchor region and the XPD subunit. ..
  91. Doughan B, Rollins J. Characterization of MAT gene functions in the life cycle of Sclerotinia sclerotiorum reveals a lineage-specific MAT gene functioning in apothecium morphogenesis. Fungal Biol. 2016;120:1105-17 pubmed publisher
    ..Experimentally, loss-of-function mutants were created for the conserved core mating-type genes (MAT1-1-1, and MAT1-2-1), and the lineage-specific genes found only in S...
  92. Carvajal Campos A, Manizan A, Tadrist S, Akaki D, Koffi Nevry R, Moore G, et al. Aspergillus korhogoensis, a Novel Aflatoxin Producing Species from the Côte d'Ivoire. Toxins (Basel). 2017;9: pubmed publisher
    ..korhogoensis as a heterothallic species, since three isolates exhibited a singular MAT1-1 locus and one isolate exhibited a singular MAT1-2 locus...