Gene Symbol: MMS22L
Description: MMS22 like, DNA repair protein
Alias: C6orf167, dJ39B17.2, protein MMS22-like
Species: human
Products:     MMS22L

Top Publications

  1. Leone M, Barizzone N, Esposito F, Lucenti A, Harbo H, Goris A, et al. Association of genetic markers with CSF oligoclonal bands in multiple sclerosis patients. PLoS ONE. 2013;8:e64408 pubmed publisher
    ..4×10(-7)) outside the HLA region (65 Mb). genetic factors predispose to the development of OCB. ..
  2. Schrörs B, Lübcke S, Lennerz V, Fatho M, Bicker A, Wölfel C, et al. HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model. Oncotarget. 2017;8:28312-28327 pubmed publisher
    ..These findings corroborate that, although neoantigens represent attractive therapeutic targets, they also contribute to the process of cancer immunoediting as a serious limitation to specific T cell immunotherapy. ..
  3. Piwko W, Olma M, Held M, Bianco J, Pedrioli P, Hofmann K, et al. RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells. EMBO J. 2010;29:4210-22 pubmed publisher
    ..We discovered C6orf167/Mms22-like protein (Mms22L) as a putative human orthologue of budding yeast Mms22, which, together with cullin ..
  4. Piwko W, Buser R, Peter M. Rescuing stalled replication forks: MMS22L-TONSL, a novel complex for DNA replication fork repair in human cells. Cell Cycle. 2011;10:1703-5 pubmed
  5. O Donnell L, Panier S, Wildenhain J, Tkach J, Al Hakim A, Landry M, et al. The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Mol Cell. 2010;40:619-31 pubmed publisher
    ..Here we report the identification of a complex composed of MMS22L (C6ORF167) and TONSL (NFKBIL2) that participates in the recovery from replication stress...
  6. Duro E, Lundin C, Ask K, Sanchez Pulido L, MacArtney T, Toth R, et al. Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell. 2010;40:632-44 pubmed publisher
    ..Here we identify a human Mms22-like protein (MMS22L) and an MMS22L-interacting protein, NF?BIL2/TONSL...
  7. O Connell B, Adamson B, Lydeard J, Sowa M, Ciccia A, Bredemeyer A, et al. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010;40:645-57 pubmed publisher
    ..Among numerous candidate genes are two previously unstudied proteins: the ankyrin repeat protein NFKBIL2 and C6ORF167 (MMS22L), distantly related to yeast replication stress regulator Mms22p...
  8. Nguyen M, Ueda K, Nakamura Y, Daigo Y. Identification of a novel oncogene, MMS22L, involved in lung and esophageal carcinogenesis. Int J Oncol. 2012;41:1285-96 pubmed publisher
    ..expression profile analyses using a cDNA microarray containing 27,648 genes or expressed sequence tags identified MMS22L (methyl methanesulfonate-sensitivity protein 22-like) to be overexpressed in the majority of clinical lung and ..
  9. Saredi G, Huang H, Hammond C, Alabert C, Bekker Jensen S, Forne I, et al. H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex. Nature. 2016;534:714-718 pubmed publisher
    ..incorporated during DNA replication provide a signature of post-replicative chromatin, read by the human TONSL–MMS22L homologous recombination complex...

More Information


  1. Piwko W, Mlejnkova L, Mutreja K, Ranjha L, Stafa D, Smirnov A, et al. The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress. EMBO J. 2016;35:2584-2601 pubmed
    ..Using in vivo and in vitro approaches, we show that the MMS22L-TONSL heterodimer localizes to replication forks under unperturbed conditions and its recruitment is increased ..