MMP20

Summary

Gene Symbol: MMP20
Description: matrix metallopeptidase 20
Alias: AI2A2, MMP-20, matrix metalloproteinase-20, enamel metalloproteinase, matrix metalloproteinase 20 (enamelysin)
Species: human
Products:     MMP20

Top Publications

  1. Rey T, Tarabeux J, Gerard B, Delbarre M, Le Béchec A, Stoetzel C, et al. Protocol GenoDENT: Implementation of a New NGS Panel for Molecular Diagnosis of Genetic Disorders with Orodental Involvement. Methods Mol Biol. 2019;1922:407-452 pubmed publisher
    ..for example, mutations in a number of genes have been reported to cause isolated AI, including AMELX, ENAM, KLK4, MMP20, FAM83H, WDR72, C4orf26, SLC24A4, and LAMB3...
  2. Vasconcelos K, Arid J, Evangelista S, Oliveira S, Dutra A, Silva L, et al. MMP13 Contributes to Dental Caries Associated with Developmental Defects of Enamel. Caries Res. 2019;:1-6 pubmed publisher
    The aim of this study was to investigate the association between genetic polymorphisms in MMP8, MMP13, and MMP20 with caries experience and developmental defects of enamel (DDE) in children from the Amazon region of Brazil...
  3. Tye C, Sharma R, Smith C, Bartlett J. Altered ion-responsive gene expression in Mmp20 null mice. J Dent Res. 2010;89:1421-6 pubmed publisher
    ..Less hydroxyapatite forms in matrix metalloproteinase-20 null (Mmp20(-/-)) mouse incisors, because enamel thickness is reduced by approximately 50%...
  4. Okubo M, Chiba R, Karakida T, Yamazaki H, Yamamoto R, Kobayashi S, et al. Potential function of TGF-β isoforms in maturation-stage ameloblasts. J Oral Biosci. 2019;61:43-54 pubmed publisher
    ..In vivo activation of TGF-β was characterized by using matrix metalloproteinase 20 null (Mmp20-/-) and wild-type (Mmp20+/+) mice...
  5. Romualdo P, Pucinelli C, Tannure P, Nelson Filho P, Segato R, Brancher J, et al. Evaluation of genetic polymorphisms in MMP2, MMP9 and MMP20 in Brazilian children with dental fluorosis. Environ Toxicol Pharmacol. 2019;66:104-108 pubmed publisher
    ..This study evaluated if MMP2, MMP9 and MMP20 are expressed during enamel development and assessed the association between polymorphisms in these genes with DF...
  6. Yan Z, Chen G, Yang Y, Sun L, Jiang Z, Feng L, et al. Expression and roles of syndecan-4 in dental epithelial cell differentiation. Int J Mol Med. 2014;34:1301-8 pubmed publisher
    ..Taken together, these results suggest that SDC4 participates in amelogenesis, and FGF10 may modulate dental epithelial cell behaviors through the regulation of SDC4 expression. ..
  7. Hu J, Sun J, Chen W, Yang Y, Xu Y, Wu Y, et al. [Huangjing Zanyu Capsule enhances sperm mitochondrial membrane potential in asthenozoospermia patients]. Zhonghua Nan Ke Xue. 2017;23:1116-1120 pubmed
    ..26)具有显著相关性(p<0.01)。结论: 黄精赞育胶囊能提高精子mmp值,改善线粒体功能,从而有效增加精子活力及pr%并改善精子形态,对治疗弱精子症安全有效。. ..
  8. Song W, Wang Y, Chu Q, Qi C, Gao Y, Gao Y, et al. Loss of transforming growth factor-β1 in epithelium cells affects enamel formation in mice. Arch Oral Biol. 2018;96:146-154 pubmed publisher
    ..TGF-β1 played an important role in enamel mineralization through decreasing synthesis ofAmelx, Ambn and Enam and increasing synthesis of Klk4, Amtn, Corf26 and Wdr72. ..
  9. Fan L, Deng S, Sui X, Liu M, Cheng S, Wang Y, et al. Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralization. J Mol Histol. 2018;49:499-507 pubmed publisher
    ..Meanwhile, the amelogenesis-related proteinases Mmp20 and Klk4 were decreased in the incisors of CA-β-catenin mice...

More Information

Publications80

  1. Guo F, Feng J, Wang F, Li W, Gao Q, Chen Z, et al. Bmp2 deletion causes an amelogenesis imperfecta phenotype via regulating enamel gene expression. J Cell Physiol. 2015;230:1871-82 pubmed publisher
    ..Exogenous Bmp2 up-regulated those gene expressions in mouse enamel organ epithelial cells. This result for the first time indicates Bmp2 signaling is essential for proper enamel development and mineralization in vivo. ..
  2. Nakayama Y, Holcroft J, Ganss B. Enamel Hypomineralization and Structural Defects in Amelotin-deficient Mice. J Dent Res. 2015;94:697-705 pubmed publisher
    ..This role appears to be largely independent of other enamel proteins. ..
  3. Li J, Wang P, Gao J, Fei X, Liu Y, Ruan J. NaF Reduces KLK4 Gene Expression by Decreasing Foxo1 in LS8 Cells. Biol Trace Elem Res. 2018;186:498-504 pubmed publisher
    ..study aims to investigate the possible relationship between Foxo1 and enamel matrix proteinases, matrix metalloproteinase 20 (MMP20), and kallikrein 4 (KLK4), in NaF-treated ameloblasts...
  4. Kwak S, Kim S, Yamakoshi Y, Simmer J, Beniash E, Margolis H. Regulation of calcium phosphate formation by native amelogenins in vitro. Connect Tissue Res. 2014;55 Suppl 1:21-4 pubmed publisher
    ..during secretory stage amelogenesis may be regulated by the partial removal of full-length amelogenin via MMP20 proteolysis, while predominant amelogenin degradation products, like P148, serve to prevent uncontrolled mineral ..
  5. Yamakawa S, Niwa T, Karakida T, Kobayashi K, Yamamoto R, Chiba R, et al. Effects of Er:YAG and Diode Laser Irradiation on Dental Pulp Cells and Tissues. Int J Mol Sci. 2018;19: pubmed publisher
    ..Both LIs activated four MMPs in porcine dental pulp tissues. We helped elucidate how reparative dentin is formed during laser treatments. ..
  6. Buchko G, Jayasinha Arachchige R, Tao J, Tarasevich B, Shaw W. Identification of major matrix metalloproteinase-20 proteolytic processing products of murine amelogenin and tyrosine-rich amelogenin peptide using a nuclear magnetic resonance spectroscopy based method. Arch Oral Biol. 2018;93:187-194 pubmed publisher
    The aim of this study was to identify major matrix metalloproteinase-20 (MMP20) proteolytic processing products of amelogenin over time and determine if the tyrosine-rich amelogenin peptide (TRAP) was a substrate of MMP20...
  7. Saxena G, Koli K, De la Garza J, Ogbureke K. Matrix metalloproteinase 20-dentin sialophosphoprotein interaction in oral cancer. J Dent Res. 2015;94:584-93 pubmed publisher
    b>Matrix metalloproteinase 20 (MMP-20), widely regarded as tooth specific, participates with MMP-2 in processing dentin sialophosphoprotein (DSPP) into dentin sialoprotein, dentin phosphoprotein, and dentin glycoprotein...
  8. Ren C, Amm H, DeVilliers P, Wu Y, Deatherage J, Liu Z, et al. Targeting the sonic hedgehog pathway in keratocystic odontogenic tumor. J Biol Chem. 2012;287:27117-25 pubmed publisher
  9. Sarkar J, Simanian E, Tuggy S, Bartlett J, Snead M, Sugiyama T, et al. Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression. Front Physiol. 2014;5:277 pubmed publisher
    ..LS8 cells express greater mRNA levels for genes that define secretory-stage activities (Amelx, Ambn, Enam, and Mmp20), while ALC express greater mRNA levels for genes that define maturation-stage activities (Odam and Klk4)...
  10. Shukla S, Sikder K, Sarkar A, Addya S, Rafiq K. Molecular network, pathway, and functional analysis of time-dependent gene changes related to cathepsin G exposure in neonatal rat cardiomyocytes. Gene. 2018;: pubmed publisher
    ..SMAD6, NR4A1, FOSL2, ID3 and SLAMF7, and down-regulated genes included CYR61, GDF6, Olr640, Vom2r36, DUSP6 and MMP20. Our data suggest that there are multiple deregulated pathways associated with cardiomyocyte death after CG ..
  11. Chu Q, Gao Y, Gao X, Dong Z, Song W, Xu Z, et al. Ablation of Runx2 in Ameloblasts Suppresses Enamel Maturation in Tooth Development. Sci Rep. 2018;8:9594 pubmed publisher
    ..Taken together, Runx2 played critical roles in controlling enamel maturation by increasing synthesis of KLK4 and decreasing synthesis of AMELX, AMBN and ENAM. ..
  12. Pugach M, Ozer F, Mulmadgi R, Li Y, Suggs C, Wright J, et al. Shear bond strength of dentin and deproteinized enamel of amelogenesis imperfecta mouse incisors. Pediatr Dent. 2014;36:130-6 pubmed
  13. Becerik S, Cogulu D, Emingil G, Han T, Hart P, Hart T. Exclusion of candidate genes in seven Turkish families with autosomal recessive amelogenesis imperfecta. Am J Med Genet A. 2009;149A:1392-8 pubmed publisher
    ..for evidence of a genetic etiology of AI for the seven major candidate gene loci (AMBN, AMELX, ENAM, FAM83H, KLK4, MMP20, and TUFT1). Dental and periodontal characteristics of the affected members of these families were also described...
  14. Okamoto M, Takahashi Y, Komichi S, Cooper P, Hayashi M. Dentinogenic effects of extracted dentin matrix components digested with matrix metalloproteinases. Sci Rep. 2018;8:10690 pubmed publisher
    ..Our results indicate that MMP-20 may be especially effective in stimulating wound healing of the dentin-pulp complex. ..
  15. Halusic A, Sepich V, Shirley D, Granjeiro J, Costa M, Küchler E, et al. Calcium and magnesium levels in primary tooth enamel and genetic variation in enamel formation genes. Pediatr Dent. 2014;36:384-8 pubmed
    ..of demineralization and remineralization of teeth from individuals whose genotypes for selected genes (ENAM, MMP20, TUFT, TFIP, and AMBN) are known...
  16. Xia Y, Ren A, Pugach M. Truncated amelogenin and LRAP transgenes improve Amelx null mouse enamel. Matrix Biol. 2016;52-54:198-206 pubmed publisher
    ..Soon after secretion by ameloblasts, M180 is cleaved by MMP20 resulting in C-terminal truncated (CTRNC) amelogenin...
  17. Prajapati S, Tao J, Ruan Q, De Yoreo J, Moradian Oldak J. Matrix metalloproteinase-20 mediates dental enamel biomineralization by preventing protein occlusion inside apatite crystals. Biomaterials. 2016;75:260-270 pubmed publisher
    ..Elucidating such molecular mechanisms can be applied in the design of novel biomaterials for future clinical applications in dental restoration or repair. ..
  18. Salmon C, Giorgetti A, Paes Leme A, Domingues R, Kolli T, Foster B, et al. Microproteome of dentoalveolar tissues. Bone. 2017;101:219-229 pubmed publisher
    ..The DE proteome included known and novel mineralization regulators, including matrix metalloproteinase 20 (MMP-20), 5' nucleotidase (NT5E), and secreted phosphoprotein 24 (SPP-24 or SPP-2)...
  19. Hu Y, Smith C, Richardson A, Bartlett J, Hu J, Simmer J. MMP20, KLK4, and MMP20/KLK4 double null mice define roles for matrix proteases during dental enamel formation. Mol Genet Genomic Med. 2016;4:178-96 pubmed publisher
    b>Matrix metalloproteinase 20 (MMP20) and kallikrein-related peptidase 4 (KLK4) are secreted proteinases that are essential for proper dental enamel formation...
  20. Mancikova V, Montero Conde C, Perales Paton J, Fernández A, Santacana M, Jodkowska K, et al. Multilayer OMIC Data in Medullary Thyroid Carcinoma Identifies the STAT3 Pathway as a Potential Therapeutic Target in RETM918T Tumors. Clin Cancer Res. 2017;23:1334-1345 pubmed publisher
    ..These in silico findings were confirmed in vitro for PLCB2, DKK4, MMP20, and miR-10a, -30a, and -200c...
  21. Niwa T, Yamakoshi Y, Yamazaki H, Karakida T, Chiba R, Hu J, et al. The dynamics of TGF-β in dental pulp, odontoblasts and dentin. Sci Rep. 2018;8:4450 pubmed publisher
    ..Activated TGF-β1 enhances the mRNA expression levels of MMP20 and full-length dentin sialophosphoprotein (DSPP) in dental pulp cells, coinciding with the induction of ..
  22. Nurbaeva M, Eckstein M, Snead M, Feske S, Lacruz R. Store-operated Ca2+ Entry Modulates the Expression of Enamel Genes. J Dent Res. 2015;94:1471-7 pubmed publisher
    ..primary enamel organ cells with thapsigargin to activate SOCE leads to increased expression of Amelx, Ambn, Enam, Mmp20. This effect is reversed when cells are treated with a CRAC channel inhibitor...
  23. Atalayin C, Tezel H, Dagci T, Yavasoglu N, Oktem G. Medium modification with bone morphogenetic protein 2 addition for odontogenic differentiation. Braz Oral Res. 2016;30: pubmed publisher
    ..The expression of dentin sialophosphoprotein, dentin matrix protein 1, enamelysin/matrix metalloproteinase 20 and the phosphate-regulating gene with homologies to endopeptidases on the X chromosome of the cells ..
  24. Springer M, Starrett J, Morin P, Lanzetti A, Hayashi C, Gatesy J. Inactivation of C4orf26 in toothless placental mammals. Mol Phylogenet Evol. 2016;95:34-45 pubmed publisher
    Previous studies have reported inactivated copies of six enamel-related genes (AMBN, AMEL, AMTN, ENAM, KLK4, MMP20) and one dentin-related gene (DSPP) in one or more toothless vertebrates and/or vertebrates with enamelless teeth, thereby ..
  25. Kawamura R, Hayashi Y, Murakami H, Nakashima M. EDTA soluble chemical components and the conditioned medium from mobilized dental pulp stem cells contain an inductive microenvironment, promoting cell proliferation, migration, and odontoblastic differentiation. Stem Cell Res Ther. 2016;7:77 pubmed publisher
  26. Shahid M, Balto H, Al Hammad N, Joshi S, Khalil H, Somily A, et al. Mutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis. Eur J Med Genet. 2016;59:377-85 pubmed publisher
    ..that include four in MSX1, one in PAX9 and one single nucleotide polymorphism (SNP) in majority of the patients in MMP20. One novel mutation in exon 1 of MSX1 gene (5354C > G; A40G) was found in three patients...
  27. Kraus D, Reckenbeil J, Perner S, Winter J, Probstmeier R. Expression Pattern of Matrix Metalloproteinase 20 (MMP20) in Human Tumors. Anticancer Res. 2016;36:2713-8 pubmed
    b>Matrix metalloproteinase 20 (MMP20) is a member of the family of matrix metalloproteinases. Under normal conditions the expression of MMP20 is restricted to ameloblasts and odontoblasts...
  28. Rajasekaran S, Kanna R, Reddy R, Natesan S, Raveendran M, Cheung K, et al. How Reliable Are the Reported Genetic Associations in Disc Degeneration?: The Influence of Phenotypes, Age, Population Size, and Inclusion Sequence in 809 Patients. Spine (Phila Pa 1976). 2016;41:1649-1660 pubmed
    ..with three SNPs of CILP; annular tears with rs2249350 of ADAMTS5 and rs11247361 IGF1R; modic changes with VDR and MMP20; Pfirmann grading with three SNPs of MMP20 and Schmorl node with SNPs of CALM1 and FN1 and none with Total End ..
  29. Gerreth K, Zaorska K, Zabel M, Borysewicz Lewicka M, Nowicki M. Chosen single nucleotide polymorphisms (SNPs) of enamel formation genes and dental caries in a population of Polish children. Adv Clin Exp Med. 2017;26:899-905 pubmed publisher
    ..the genotype and allele frequencies of single nucleotide polymorphisms (SNPs) in AMELX, AMBN, TUFT1, TFIP11, MMP20 and KLK4 genes and to prove their association with dental caries occurrence in a population of Polish children...
  30. Atalayin C, Tezel H, Dagci T, Karabay Yavaşoğlu N, Oktem G, Kose T. In vivo performance of different scaffolds for dental pulp stem cells induced for odontogenic differentiation. Braz Oral Res. 2016;30:e120 pubmed publisher
    ..The expression levels of dentin sialo-phosphoprotein (DSPP), dentin matrix protein-1 (DMP1), enamelysin/matrix metalloproteinase 20 (MMP20) and phosphate-regulating gene with homologies to endopeptidases on X chromosome (PHEX) were ..
  31. Kobayashi Kinoshita S, Yamakoshi Y, Onuma K, Yamamoto R, Asada Y. TGF-β1 autocrine signalling and enamel matrix components. Sci Rep. 2016;6:33644 pubmed publisher
    ..Latent TGF-β1 is activated by matrix metalloproteinase 20 (MMP20), coinciding with amelogenin processing by the same proteinase...
  32. Uskoković V. Prospects and Pits on the Path of Biomimetics: The case of tooth enamel. J Biomim Biomater Tissue Eng. 2010;8:45-78 pubmed
    ..The idea that a preassembling protein matrix serves as a template for the uniaxial growth of apatite crystals in enamel is finally challenged with the one based on co-assembly of the protein and the mineral phases. ..
  33. Xie X, Liu C, Zhang H, Jani P, Lu Y, Wang X, et al. Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression. Sci Rep. 2016;6:25364 pubmed publisher
    ..the mutant enamel was drastically delayed, which was coincided with the greatly reduced expression of matrix metalloproteinase 20 (MMP20) and kallikrein 4 (KLK4)...
  34. Liu C, Niu Y, Zhou X, Xu X, Yang Y, Zhang Y, et al. Cell cycle control, DNA damage repair, and apoptosis-related pathways control pre-ameloblasts differentiation during tooth development. BMC Genomics. 2015;16:592 pubmed publisher
    ..regulators (RUNX2, ETV1 and ETV5), solute carrier family members (SLC15A1 and SLC7A11), enamel matrix protein (MMP20), and a polymodal excitatory ion channel (TRPA1)...
  35. Prajapati S, Ruan Q, Mukherjee K, Nutt S, Moradian Oldak J. The Presence of MMP-20 Reinforces Biomimetic Enamel Regrowth. J Dent Res. 2018;97:84-90 pubmed publisher
    ..8- and 2.4-fold, respectively) by the MMP-20-CS-AMEL hydrogel. Although future work is needed to further incorporate other enamel matrix proteins into the system, this study brings us one step closer to biomimetic enamel regrowth. ..
  36. Lee H, Park J, Seo Y, Kim H, Lee G, Bae H, et al. Odontoblastic inductive potential of epithelial cells derived from human deciduous dental pulp. J Mol Histol. 2016;47:345-51 pubmed publisher
    ..Thus, our results indicate that DPESCs can be a realistic epithelial source for use in odontoblastic induction and dentin formation of dental mesenchymal cells. ..
  37. Kwak S, Yamakoshi Y, Simmer J, Margolis H. MMP20 Proteolysis of Native Amelogenin Regulates Mineralization In Vitro. J Dent Res. 2016;95:1511-1517 pubmed
    ..Since full-length amelogenin undergoes proteolysis by matrix metalloproteinase 20 (MMP20, enamelysin) soon after secretion, the present study was conducted to assess the effect of ..
  38. Kim J, Simmer J, Hart T, Hart P, Ramaswami M, Bartlett J, et al. MMP-20 mutation in autosomal recessive pigmented hypomaturation amelogenesis imperfecta. J Med Genet. 2005;42:271-5 pubmed
  39. Filho A, Calixto M, Deeley K, Santos N, Rosenblatt A, Vieira A. MMP20 rs1784418 Protects Certain Populations against Caries. Caries Res. 2017;51:46-51 pubmed publisher
    This work aimed to further evaluate the association of MMP20 rs1784418 C>T and dental caries experience with the hypothesis that MMP20 rs1784418 C>T is a risk factor for dental caries...
  40. Llano E, Pendas A, Knauper V, Sorsa T, Salo T, Salido E, et al. Identification and structural and functional characterization of human enamelysin (MMP-20). Biochemistry. 1997;36:15101-8 pubmed
    ..Finally, we have found that the human enamelysin gene (MMP-20) maps to chromosome 11q22, clustered to at least seven other members of the MMP gene family. ..
  41. Furukawa Y, Haruyama N, Nikaido M, Nakanishi M, Ryu N, Oh Hora M, et al. Stim1 Regulates Enamel Mineralization and Ameloblast Modulation. J Dent Res. 2017;96:1422-1429 pubmed publisher
    ..The gene expression levels of the enamel matrix proteins Amelx and Ambn and the enamel matrix proteases Mmp20 and Klk4 were not altered by the abrogation of SOCE in Stim1/2 cKO mice...
  42. Zhang Y, Li W, Chi H, Chen J, DenBesten P. JNK/c-Jun signaling pathway mediates the fluoride-induced down-regulation of MMP-20 in vitro. Matrix Biol. 2007;26:633-41 pubmed
    ..These in vitro findings suggest that c-Jun is a key regulatory element for MMP-20 expression, and human ameloblast lineage cells can respond to fluoride by down-regulating MMP-20 transcription through the JNK/c-Jun signaling pathway. ..
  43. Wright J, Hart T, Hart P, Simmons D, Suggs C, Daley B, et al. Human and mouse enamel phenotypes resulting from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4. Cells Tissues Organs. 2009;189:224-9 pubmed publisher
    Amelogenesis imperfecta (AI) is caused by AMEL, ENAM, MMP20 and KLK4 gene mutations. Mice lacking expression of the AmelX, Enam and Mmp20 genes have been generated...
  44. Lee S, Seymen F, Kang H, Lee K, Gencay K, Tuna B, et al. MMP20 hemopexin domain mutation in amelogenesis imperfecta. J Dent Res. 2010;89:46-50 pubmed publisher
    ..serve important functions during dental enamel formation, and mutations in the kallikrein 4 (KLK4) and enamelysin (MMP20) genes cause autosomal-recessive amelogenesis imperfecta (ARAI)...
  45. Liu Y, Li Y, Liu Z, Zhang L, Anniko M, Duan M. Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma. Acta Otolaryngol. 2011;131:769-73 pubmed publisher
    ..We analyzed 33 cases of LSCC with RT-PCR and 73 cases of LSCC with immunohistochemistry compared with normal laryngeal epithelium. We found that MMP-20 is overexpresssed in LSCC compared with the adjacent normal laryngeal epithelium. ..
  46. Chang H, Wang Y, Liu H, Nan X, Wong S, Peng S, et al. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis. Cell Death Dis. 2017;8:3221 pubmed publisher
    ..and osteogenesis of miR-185-5p was evaluated by RT-PCR and western blot examination of Amelx, Enam, Klk4, and Mmp20 gene and protein expression, and by Alizarin Red stain...
  47. Väänänen A, Srinivas R, Parikka M, Palosaari H, Bartlett J, Iwata K, et al. Expression and regulation of MMP-20 in human tongue carcinoma cells. J Dent Res. 2001;80:1884-9 pubmed
    ..This implies that MMP-20 not only participates in dental matrix remodeling but is also present in tongue carcinoma cells. ..
  48. Terp G, Christensen I, Jørgensen F. Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes. J Biomol Struct Dyn. 2000;17:933-46 pubmed
    ..Differences in the P1' pocket are well-documented and have been extensively exploited in inhibitor design. The present work indicates that selectivity could be further improved by considering the P2 pocket as well. ..
  49. Kim Y, Kang J, Seymen F, Koruyucu M, Gencay K, Shin T, et al. Analyses of MMP20 Missense Mutations in Two Families with Hypomaturation Amelogenesis Imperfecta. Front Physiol. 2017;8:229 pubmed publisher
    ..2, hg19) and sequence variations were annotated with the dbSNP build 138. Mutations in MMP20 were identified in both probands. A homozygous missense mutation (c.678T>A; p...
  50. Yoon H, Blaber S, Li W, Scarisbrick I, Blaber M. Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases. Biol Chem. 2013;394:137-47 pubmed publisher
    ..The results identify MMP-20 as a broad activator of pro-KLKs, suggesting the potential for intersection of the KLK and MMP axes under pathological dysregulation of MMP-20 expression. ..
  51. Urzúa B, Ortega Pinto A, Farias D, Franco E, Morales Bozo I, Moncada G, et al. A multidisciplinary approach for the diagnosis of hypocalcified amelogenesis imperfecta in two Chilean families. Acta Odontol Scand. 2012;70:7-14 pubmed publisher
    ..A multidisciplinary analysis allowed for a diagnosis of hypocalcified amelogenesis imperfecta, Witkop type III, which was unrelated to previously described mutations in the ENAM or MMP-20 genes. ..
  52. Gasse B, Karayigit E, Mathieu E, Jung S, Garret A, Huckert M, et al. Homozygous and compound heterozygous MMP20 mutations in amelogenesis imperfecta. J Dent Res. 2013;92:598-603 pubmed publisher
    ..hypomaturation autosomal-recessive-type amelogenesis imperfecta (type IIA2) and describe 2 new causal Matrix metalloproteinase 20 (MMP20) mutations validated in two unrelated families: a missense mutation p...
  53. Tannure P, Kuchler E, Lips A, Costa M, Luiz R, Granjeiro J, et al. Genetic variation in MMP20 contributes to higher caries experience. J Dent. 2012;40:381-6 pubmed publisher
    ..To evaluate the association between MMP20 and caries experience in Brazilian children...
  54. Han S, Lee H, Oh Y, Lee J, Kim S, Ha J, et al. Identification of the effects of aging-related gene-matrix metalloproteinase on allograft outcomes in kidney transplantation. Transplant Proc. 2013;45:2158-64 pubmed publisher
    ..conducted to analyze correlations between polymorphisms of MMP genes [rs880197 in MMP7 (A>T) and rs1711437 in MMP20 (G>A)] and transplant outcomes in 235 recipients...
  55. Seymen F, Park J, Lee K, Lee H, Lee D, Koruyucu M, et al. Novel MMP20 and KLK4 Mutations in Amelogenesis Imperfecta. J Dent Res. 2015;94:1063-9 pubmed publisher
    ..Mutations in the kallikrein 4 (KLK4), enamelysin (MMP20), and WDR72 genes have been identified as causing hypomaturation enamel defects in an autosomal-recessive ..
  56. Miyashita S, Ahmed N, Murakami M, Iohara K, Yamamoto T, Horibe H, et al. Mechanical forces induce odontoblastic differentiation of mesenchymal stem cells on three-dimensional biomimetic scaffolds. J Tissue Eng Regen Med. 2017;11:434-446 pubmed publisher
    ..The 3D biomimetic scaffolds with dentinal tubule-like pores were critical for the odontoblastic differentiation of MSCs induced by mechanical compression. Copyright © 2014 John Wiley & Sons, Ltd. ..
  57. Ogbureke K, Koli K, Saxena G. Matrix Metalloproteinase 20 Co-expression With Dentin Sialophosphoprotein in Human and Monkey Kidneys. J Histochem Cytochem. 2016;64:623-36 pubmed publisher
    We recently reported the expression of matrix metalloproteinase 20 (MMP20), hitherto thought to be tooth specific, in the metabolically active ductal epithelial cells of human salivary glands...
  58. Küchler E, Menezes R, Callahan N, Costa M, Modesto A, Meira R, et al. MMP1 and MMP20 contribute to tooth agenesis in humans. Arch Oral Biol. 2011;56:506-11 pubmed publisher
    ..The aim of this study was to investigate the possible association between MMP1, MMP3, and MMP20 and tooth agenesis...
  59. Wojciechowski R, Bailey Wilson J, Stambolian D. Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families. Invest Ophthalmol Vis Sci. 2010;51:4989-95 pubmed publisher
    ..The results suggest that the MMP1 and MMP2 genes are involved in refractive variation in the AMISH. Genetic and/or environmental heterogeneity most likely contribute to differences in association results between ethnic groups. ..
  60. Väänänen A, Tjäderhane L, Eklund L, Heljasvaara R, Pihlajaniemi T, Herva R, et al. Expression of collagen XVIII and MMP-20 in developing teeth and odontogenic tumors. Matrix Biol. 2004;23:153-61 pubmed
    ..Our results show that collagen XVIII is present in developing teeth, but its absence seems not to be critical for the development of the teeth. ..
  61. Stracke J, Fosang A, Last K, Mercuri F, Pendas A, Llano E, et al. Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP). FEBS Lett. 2000;478:52-6 pubmed
  62. Wang S, Hu Y, Simmer J, Seymen F, Estrella N, Pal S, et al. Novel KLK4 and MMP20 mutations discovered by whole-exome sequencing. J Dent Res. 2013;92:266-71 pubmed publisher
    ..6930delG; c.245delG; p.Gly82Alafs*87) that shifted the reading frame, a novel missense transition mutation in both MMP20 alleles (g.15390A>G; c.611A>G; p...
  63. Guimarães D, Antunes D, Saturno J, Massuda F, Paiva K, Nunes F. Immunohistochemical expression of WNT5A and MMPs in odontogenic epithelial tumors and cysts. Acta Histochem. 2015;117:667-74 pubmed publisher
    ..b>MMP20 expression was higher in ameloblastoma when compared to adenomatoid odontogenic tumor (AOT), DC and GOC...
  64. Pang L, Zhi Q, Zhuang P, Yu L, Tao Y, Lin H. Variation in Enamel Formation Genes Influences Enamel Demineralization In Vitro in a Streptococcus mutans Biofilm Model. Front Physiol. 2017;8:851 pubmed publisher
    ..The GG genotype of TUFT1 (rs17640579) and the GT genotype of MMP20 (rs1612069) exhibited increased microhardness (p = 0.044 and 0.016, respectively)...
  65. Akagi Kurashige Y, Yamashiro K, Gotoh N, Miyake M, Morooka S, Yoshikawa M, et al. MMP20 and ARMS2/HTRA1 Are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration. Ophthalmology. 2015;122:2295-2302.e2 pubmed publisher
    ..Genes associated with the lesion size in neovascular AMD. In the discovery stage, rs10895322 in MMP20 showed a genome-wide significant P value of 6.95×10(-8), and rs2284665 in ARMS2/HTRA1 showed a P value of 1...
  66. Pendas A, Santamaria I, Alvarez M, Pritchard M, Lopez Otin C. Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3. Genomics. 1996;37:266-8 pubmed
  67. Tanimoto K, Le T, Zhu L, Witkowska H, Robinson S, Hall S, et al. Reduced amelogenin-MMP20 interactions in amelogenesis imperfecta. J Dent Res. 2008;87:451-5 pubmed
    Amelogenin with a proline 41 to threonine mutation (P41T) is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis imperfecta (AI)...
  68. Chang X, Zhao Y, Hou C, Glessner J, McDaniel L, Diamond M, et al. Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk. Nat Commun. 2017;8:569 pubmed publisher
    ..Here we identify common variants at 11q22.2 within MMP20 that associate with neuroblastoma cases harboring 11q deletion (rs10895322), using GWAS in 113 European-American ..
  69. Zhai L, Wu Y, Cai C, Huang Q, Tang Z. High-Level Expression and Prognostic Significance of Matrix Metalloprotease-19 and Matrix Metalloprotease-20 in Human Pancreatic Ductal Adenocarcinoma. Pancreas. 2016;45:1067-72 pubmed publisher
    ..High-level expression of MMP-19 and MMP-20 is closely correlated to progression and prognosis of PDAC, and these may be considered as promising markers for unfavorable prognoses. ..
  70. Bartlett J, Simmer J. Proteinases in developing dental enamel. Crit Rev Oral Biol Med. 1999;10:425-41 pubmed
    ..Other, as yet unidentified, proteinases and proteinase inhibitors are almost certainly present within the forming enamel and await discovery...
  71. Koli K, Saxena G, Ogbureke K. Expression of Matrix Metalloproteinase (MMP)-20 and Potential Interaction with Dentin Sialophosphoprotein (DSPP) in Human Major Salivary Glands. J Histochem Cytochem. 2015;63:524-33 pubmed publisher
    ..This report reinforces our earlier suggestion that the SIBLING-MMP complexes may be involved in the turnover of extracellular proteins damaged by oxidation byproducts in metabolically active duct epithelial systems. ..