MMP17

Summary

Gene Symbol: MMP17
Description: matrix metallopeptidase 17
Alias: MMP-17, MT4-MMP, MT4MMP, MTMMP4, matrix metalloproteinase-17, MT-MMP 4, matrix metallopeptidase 17 (membrane-inserted), matrix metalloproteinase 17 (membrane-inserted), membrane-type matrix metalloproteinase 4, membrane-type-4 matrix metalloproteinase
Species: human

Top Publications

  1. ncbi Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes
    G E Terp
    Royal Danish School of Pharmacy, Department of Medicinal Chemistry, Copenhagen, Denmark
    J Biomol Struct Dyn 17:933-46. 2000
  2. ncbi Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP
    S Kojima
    Helix Research Institute, Inc, Chiba, Japan
    FEBS Lett 480:142-6. 2000
  3. ncbi mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue
    Monika Jung
    Department of Urology, University Hospital Charite, Humboldt University Berlin, Berlin, Germany
    Prostate 55:89-98. 2003
  4. pmc MT-MMPS as Regulators of Vessel Stability Associated with Angiogenesis
    Nor Eddine Sounni
    Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer, University of Liege Liège, Belgium
    Front Pharmacol 2:111. 2011
  5. doi Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells
    Alice Truong
    Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer GIGA Cancer, University of Liege, Belgium
    FEBS J 283:704-22. 2016
  6. doi Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice
    Mara Martín-Alonso
    From the Department of Vascular Biology and Inflammation M M A, A A, N M B, A P, J M R, A G A, Proteomics Unit E C, J V and Bioinformatics Unit F M, Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, Madrid, Spain Department of Pharmacology Nephrology, Faculty of Medicine, Universidad Autonoma de Madrid, Madrid, Spain A B G R, M S Department of Internal Medicine, University of Texas Health Science Center at Houston, TX D G, D M Department of Basic Biomedical Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain C S C Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ D T D and Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan M S
    Circ Res 117:e13-26. 2015
  7. doi Histone Methyltransferase hSETD1A Is a Novel Regulator of Metastasis in Breast Cancer
    Tal Salz
    Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, Florida
    Mol Cancer Res 13:461-9. 2015
  8. doi EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP
    Alexandra Paye
    Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer GIGA Cancer, University of Liege, Liege, Belgium
    Cancer Res 74:6758-70. 2014
  9. ncbi ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on sy
    Gui Gao
    Center For Research in Skeletal Development and Paediatric Orthopaedics, Shriners Hospital for Children, Tampa, Florida 33612 9499, USA
    J Biol Chem 279:10042-51. 2004
  10. ncbi The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells
    Dmitri V Rozanov
    Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 279:4260-8. 2004

Scientific Experts

  • Rose K Davidson
  • Parth Patwari
  • Monika Jung
  • W R English
  • Nobuo Funatsu
  • Duanqing Pei
  • I Takei
  • San Ching
  • Agnes Noel
  • Lianbing Lin
  • A M Belkin
  • Ramkumar Menon
  • Aylin Rizki
  • K M Clements
  • Alexandra Paye
  • Nor Eddine Sounni
  • Silvia Blacher
  • Carine Munaut
  • Motoharu Seiki
  • Jean Michel Foidart
  • Anjum Sohail
  • Alice Truong
  • Vincent Chabottaux
  • Lorin Host
  • M Seiki
  • Mara Martín-Alonso
  • Tal Salz
  • Cassandre Yip
  • Lili Nimri
  • Tobias Freilinger
  • Manakan B Srichai
  • Erik Maquoi
  • Rafael Fridman
  • Huiren Zhao
  • Fang Yan
  • Sergey A Shiryaev
  • Chi Hung Huang
  • Y Itoh
  • H Kinoh
  • M Kajita
  • Akiko Rikimaru
  • Alex Y Strongin
  • Gillian Murphy
  • Susan J Atkinson
  • Helge Bertram
  • Ludmila Szabova
  • Cristina Diodovich
  • Ikuo Yana
  • Margreet Plaisier
  • Gui Gao
  • X S Puente
  • Kari Casas
  • Dmitri V Rozanov
  • Kenn Holmbeck
  • Henning Birkedal-Hansen
  • A Okada
  • Katarina Wolf
  • Christophe Deroanne
  • Junichiro Kamochi
  • Marie Christine Gauthier
  • Kevin Brown
  • Jesus Vazquez
  • Alicia G Arroyo
  • Nerea Méndez-Barbero
  • Arántzazu Alfranca
  • Angela Pollán
  • Suming Huang
  • Dianna Milewicz
  • David T Denhardt
  • Cristina Sánchez-Camacho
  • Emilio Camafeita
  • Yi Qiu
  • Dietmar Siemann
  • Changwang Deng
  • Mercedes Salaices
  • Dongchuan Guo
  • Fernando Martinez
  • Christine Pampo
  • Juan Miguel Redondo
  • Ana B García-Redondo
  • Kevin B Hotary
  • Jonathan Cimino
  • Guy Jerusalem
  • Stephen J Fortunato
  • Joelle Collignon
  • Didier Cataldo
  • Philippe Delvenne
  • Hossei Barak
  • Lutz Graeve
  • H Sato

Detail Information

Publications54

  1. ncbi Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes
    G E Terp
    Royal Danish School of Pharmacy, Department of Medicinal Chemistry, Copenhagen, Denmark
    J Biomol Struct Dyn 17:933-46. 2000
    ..Differences in the P1' pocket are well-documented and have been extensively exploited in inhibitor design. The present work indicates that selectivity could be further improved by considering the P2 pocket as well...
  2. ncbi Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP
    S Kojima
    Helix Research Institute, Inc, Chiba, Japan
    FEBS Lett 480:142-6. 2000
    ..These results strongly indicate that MT6-MMP is a GPI-anchored protein. Since two members of MT-MMPs are now assigned as GPI-anchored proteinase, MT-MMPs can be subgrouped into GPI type and transmembrane type...
  3. ncbi mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue
    Monika Jung
    Department of Urology, University Hospital Charite, Humboldt University Berlin, Berlin, Germany
    Prostate 55:89-98. 2003
    ....
  4. pmc MT-MMPS as Regulators of Vessel Stability Associated with Angiogenesis
    Nor Eddine Sounni
    Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer, University of Liege Liège, Belgium
    Front Pharmacol 2:111. 2011
    ..This review will shed lights on the emerging roles of MT1-MMP and MT4-MMP in vascular system alterations associated with cancer progression...
  5. doi Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells
    Alice Truong
    Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer GIGA Cancer, University of Liege, Belgium
    FEBS J 283:704-22. 2016
    b>Membrane type 4 matrix metalloproteinase (MT4-MMP) [matrix metalloproteinase (MMP) 17] is a GPI-anchored membrane-type MMP expressed on the cell surface of human breast cancer cells...
  6. doi Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice
    Mara Martín-Alonso
    From the Department of Vascular Biology and Inflammation M M A, A A, N M B, A P, J M R, A G A, Proteomics Unit E C, J V and Bioinformatics Unit F M, Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, Madrid, Spain Department of Pharmacology Nephrology, Faculty of Medicine, Universidad Autonoma de Madrid, Madrid, Spain A B G R, M S Department of Internal Medicine, University of Texas Health Science Center at Houston, TX D G, D M Department of Basic Biomedical Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, Spain C S C Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ D T D and Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan M S
    Circ Res 117:e13-26. 2015
    ..However, as many as 75% of patients with a family history of aortic aneurysms do not have an identified genetic syndrome...
  7. doi Histone Methyltransferase hSETD1A Is a Novel Regulator of Metastasis in Breast Cancer
    Tal Salz
    Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, Florida
    Mol Cancer Res 13:461-9. 2015
    ..Furthermore, a group of matrix metalloproteinases (including MMP2, MMP9, MMP12, MMP13, and MMP17) were identified which were downregulated upon depletion of hSETD1A and demonstrated a decrease in H3K4me3 at ..
  8. doi EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP
    Alexandra Paye
    Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer GIGA Cancer, University of Liege, Liege, Belgium
    Cancer Res 74:6758-70. 2014
    ..Altogether, our results identify MT4-MMP as a positive modifier of EGFR outside-in signaling that acts to cooperatively drive cancer cell proliferation...
  9. ncbi ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on sy
    Gui Gao
    Center For Research in Skeletal Development and Paediatric Orthopaedics, Shriners Hospital for Children, Tampa, Florida 33612 9499, USA
    J Biol Chem 279:10042-51. 2004
    ..We conclude that ADAMTS-4 activation in this cell system involves the coordinated activity of both glycosylphosphatidyl inositol-anchored MT4-MMP and the proteoglycan form of syndecan-1 on the cell surface...
  10. ncbi The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells
    Dmitri V Rozanov
    Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 279:4260-8. 2004
    ..These events implicate MT1-MMP, not only in the activation of MMP-2, but also in the mechanisms that control the subsequent fate of MMP-2 in cells and tissues...
  11. ncbi Accelerated intervertebral disc degeneration in scoliosis versus physiological ageing develops against a background of enhanced anabolic gene expression
    Helge Bertram
    Division of Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, D 69118 Heidelberg, Germany
    Biochem Biophys Res Commun 342:963-72. 2006
    ..No differences were evident for catabolic molecules like MMP3, MMP13, MMP17, and TIMP1...
  12. ncbi Sensitivity of human cord blood cells to tetrachloroethylene: cellular and molecular endpoints
    Cristina Diodovich
    Laboratory of Hematotoxicology, ECVAM, Institute for Health and Consumer Protection, J R C, 21020 Ispra, Italy
    Arch Toxicol 79:508-14. 2005
    ..the mitogen-activated protein kinase 14 (MPK 14), or in tumor and metastasis progression as with the matrix metalloproteinase 17 (MMP 17), in cell proliferation as with c-jun and c-fos, and moreover in the apoptotic process as with ..
  13. ncbi Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases
    Vincent Chabottaux
    Laboratory of Tumor and Development Biology, Centre de Recherche en cancérologie Expérimentale, Center for Biomedical Integrative Genoproteomics, University of Liege, Belgium
    Cancer Res 66:5165-72. 2006
    ..t. blood vessels, and is associated with increased lung metastases. These results identify MT4-MMP as a new putative target to design anticancer strategies...
  14. pmc Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage
    Rose K Davidson
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Arthritis Res Ther 8:R124. 2006
    ..For MMP9, MMP10, MMP12, MMP17, MMP23, MMP28, ADAMTS4, and ADAMTS9, there is a significant correlation between expression levels in the synovium ..
  15. ncbi Involvement of membrane-type matrix metalloproteinases (MT-MMPs) in capillary tube formation by human endometrial microvascular endothelial cells: role of MT3-MMP
    Margreet Plaisier
    Department of Biomedical Research, Gaubius Laboratory TNO Prevention and Health, Zernikedreef 9, 2333 CK Leiden, The Netherlands
    J Clin Endocrinol Metab 89:5828-36. 2004
    ..Thus, in contrast to tube formation by hFMVECs, which largely depends on MT1-MMP, capillary-like tube formation by hEMVECs is, at least in part, regulated by MT3-MMP...
  16. ncbi Gene responsible for mitochondrial myopathy and sideroblastic anemia (MSA) maps to chromosome 12q24.33
    Kari Casas
    Cedars Sinai Medical Center, Ahmanson Department of Pediatrics, Steven Spielberg Pediatric Research Center, Medical Genetics Birth Defects Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Am J Med Genet A 127:44-9. 2004
    ..2 mb region of chromosome 12q24.33. This region contains 6 well described genes (SFRS8, MMP17, ULK1, PUS1, EP400, and GALNT9) and at least 15 additional putative transcripts...
  17. ncbi Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases
    Katarina Wolf
    Department of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Blood 102:3262-9. 2003
    ..Together, amoeboid shape change and contact guidance provide constitutive protease-independent mechanisms for leukocyte trafficking through interstitial tissues that are insensitive toward pharmacologic protease inhibitors...
  18. ncbi Overexpression of the thrombospondin 2 (TSP2) gene modulated by the matrix metalloproteinase family expression and production in human colon carcinoma cell line
    Junichiro Kamochi
    Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1143, Japan
    Oncol Rep 10:881-4. 2003
    ..Conversely, the SW480 transformants showed up-regulation of MMP12 and MMP17. These results suggested that the TSP2 gene is a multifunctional modulator of remodeling tissue in which matrix ..
  19. pmc Genome-wide association analysis identifies susceptibility loci for migraine without aura
    Tobias Freilinger
    Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Munich, Germany
    Nat Genet 44:777-82. 2012
    ..This study identifies the first susceptibility loci for migraine without aura, thereby expanding our knowledge of this debilitating neurological disorder...
  20. doi Restoration of caveolin-1 expression suppresses growth, membrane-type-4 metalloproteinase expression and metastasis-associated activities in colon cancer cells
    Lili Nimri
    The Robert H Smith Faculty of Agriculture, Food and Environment, School of Nutritional Sciences, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel
    Mol Carcinog 52:859-70. 2013
    ..We conclude that cav-1 orchestrates and reorganize several proteins in lipid rafts, activities directly associated with reduced tumorigenic and metastatic ability of colon cancer cells...
  21. doi The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects
    Lorin Host
    Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer, GIGA Cancer, University of Liege, Liege, Belgium
    Int J Cancer 131:1537-48. 2012
    ..It identifies MT4-MMP as a key intrinsic tumor cell determinant that contributes to the elaboration of a permissive microenvironment for metastatic dissemination...
  22. doi Isolation and characterization of a new bacteriophage MMP17 from Meiothermus
    Lianbing Lin
    Biotechnology Research Center, Kunming University of Science and Technology, Bailongsi, Kunming 650224, Yunnan, China
    Extremophiles 15:253-8. 2011
    ..In this work, a new thermophilic bacteriophage named MMP17 (Meiothermus Myoviridae phage 17) was isolated from a Meiothermus strain and was further characterized...
  23. pmc Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage
    P Patwari
    Massachusetts Institute of Technology, Department of Electrical Engineering, Cambridge, MA 02139, USA
    Osteoarthritis Cartilage 13:269-77. 2005
    ....
  24. pmc Characterization of the dimerization interface of membrane type 4 (MT4)-matrix metalloproteinase
    Anjum Sohail
    Department of Pathology and the Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 286:33178-89. 2011
    MT4-MMP (MMP17) belongs to a unique subset of membrane type-matrix metalloproteinases that are anchored to the cell surface via a glycosylphosphatidylinositol moiety. However, little is known about its biochemical properties...
  25. ncbi Differential expression of extracellular matrix and adhesion molecule genes in the brain of juvenile versus adult mice in responses to intracerebroventricular administration of IL-1
    San Ching
    Department of Oral Biology, Ohio State University, Columbus, Ohio, USA
    Neuroimmunomodulation 14:46-56. 2007
    ..This study compares the differential gene expression patterns of extracellular matrix and adhesion molecules in the brain of juvenile and adult mice...
  26. pmc Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice
    Manakan B Srichai
    Department of Medicine, Veterans Administration Hospital, Nashville, Tennessee, United States of America
    PLoS ONE 6:e17099. 2011
    ..Thus, our results show that although MT4-MMP is expressed in the kidney, this metalloproteinase does not play a major role in renal development or function; however it does appear to modify the neural stimuli that modulate thirst...
  27. pmc Membrane-type 4 matrix metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture
    Vincent Chabottaux
    Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer, University of Liege, Tour de Pathologie, Liege, Belgium
    J Cell Mol Med 13:4002-13. 2009
    ..On this basis, we propose that MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation...
  28. ncbi Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase
    Akiko Rikimaru
    Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, 108 8639, Japan
    Genes Cells 12:1091-100. 2007
    ..Thus, we have established a mutant mouse strain for analyzing the physiological functions of MT4-MMP, which also serves as a sensitive system for monitoring and tracking the expression of MT4-MMP in vivo...
  29. doi Matrix metalloproteinase 17 is necessary for cartilage aggrecan degradation in an inflammatory environment
    Kristen M Clements
    AstraZeneca R and D Charnwood, RIRA Bioscience Building 21, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK
    Ann Rheum Dis 70:683-9. 2011
    ..Recently, matrix metalloproteinase 17 (MMP17, also known as MT4-MMP) has been implicated in the activation of one of the key aggrecanases: ..
  30. pmc Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis
    Chi Hung Huang
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan
    Neoplasia 11:1371-82. 2009
    ..These findings establish a novel signaling pathway for hypoxia-mediated metastasis and elucidate the underlying regulatory mechanism and functional significance of MT4-MMP in cancer metastasis...
  31. pmc MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer
    Anjum Sohail
    Department of Pathology, School of Medicine, and Proteases and Cancer Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Cancer Metastasis Rev 27:289-302. 2008
    ..Finally, we comment on the new scientific challenges that lie ahead to better understand the function and role in cancer of these intriguing but yet unique MMPs...
  32. pmc A human breast cell model of preinvasive to invasive transition
    Aylin Rizki
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cancer Res 68:1378-87. 2008
    ..In addition, expression of matrix metalloproteinases MMP9, MMP13, MMP15, and MMP17 was up-regulated in the invasive cells...
  33. pmc Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis
    Fang Yan
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0696, USA
    Gastroenterology 136:1297-1307, e1-3. 2009
    ..Because EGFR signaling regulates cell survival, we investigated whether activation of EGFR following H pylori infection promotes gastric epithelial survival...
  34. pmc Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis
    Sergey A Shiryaev
    Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, California, United States of America
    PLoS ONE 4:e4952. 2009
    ..The splice variants of the single MBP gene (Golli-MBP BG21 and J37) are widely expressed in the neurons and also in the immune cells. The relative contribution of the individual MMPs to the MBP cleavage is not known...
  35. ncbi Messenger ribonucleic acid expression of 16 matrix metalloproteinases in bone-implant interface tissues of loose artificial hip joints
    I Takei
    Department of Orthopedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Biomed Mater Res 52:613-20. 2000
    ..Thus, many MMP type enzymes possibly contribute to prosthetic loosening and osteolysis through pathologic extracellular matrix degradation and connective tissue/bone remodeling around prostheses...
  36. ncbi Isolation of a mouse MT2-MMP gene from a lung cDNA library and identification of its product
    M Tanaka
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Takara machi, Ishikawa, Japan
    FEBS Lett 402:219-22. 1997
    ..A monoclonal antibody raised against a synthetic peptide recognized mouse MT2-MMP as a 70 kDa protein. Like MT1- and MT3-MMPs, mouse MT2-MMP caused activation of progelatinase A upon co-transfection into COS-1 cells...
  37. ncbi Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas
    H Ueno
    Department of Molecular Immunology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Cancer Res 57:2055-60. 1997
    ..These results suggest that MT1-MMP may play a key role in human breast carcinoma invasion and metastasis by being predominantly responsible for activation of proMMP-2...
  38. ncbi Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24
    X S Puente
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Oviedo, Oviedo, 33006, Spain
    Genomics 54:578-9. 1998
  39. ncbi Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts
    M Kajita
    Department of Cancer Cell Research, Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo, Japan
    FEBS Lett 457:353-6. 1999
    ..and failed to express protein, and the other is the major transcript that has an extended open reading frame and expressed 67 and 71 kDa translation products. Thus, functional mt4-mmp has been identified for the first time...
  40. ncbi Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase
    H Kolkenbrock
    Deutsches Rheumaforschungszentrum Berlin, Germany
    Biol Chem 380:1103-8. 1999
    A C-terminal truncated form of membrane-type 4 matrix metalloproteinase (MT4-MMP; MMP 17), lacking the hemopexin-like and transmembrane domain, was expressed in Escherichia coli...
  41. ncbi Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain
    Y Wang
    Department of Biochemistry, Parke Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, Michigan 48105, USA
    J Biol Chem 274:33043-9. 1999
    ..MT4-MMP is, therefore, a competent Zn(2+)-dependent MMP with unique specificity among synthetic substrates and the capability to both degrade gelatin and activate progelatinase A...
  42. ncbi Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase
    Y Itoh
    Department of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 274:34260-6. 1999
    ..GPI anchoring of MT4-MMP on the cell surface indicates a unique biological function and character for this proteinase...
  43. ncbi Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage
    D Pei
    Department of Pharmacology, University of Minnesota, Minneapolis 55455, USA
    Cell Res 9:291-303. 1999
    ..Taken together, leukolysin may be part of the proteolytic arsenal deployed by leukocytes during inflammatory responses. Molecular cloning of a novel MMP: MMP:25..
  44. ncbi Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2-->
    H Kinoh
    Department of Cancer Cell Research, Institute of Medical Science, The University of Tokyo, Japan
    Cytogenet Cell Genet 87:97-8. 1999
  45. ncbi Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2
    W R English
    School of Biological Sciences, University of East Anglia, University Plain, Norwich, Norfolk NR4 7TJ, United Kingdom
    J Biol Chem 275:14046-55. 2000
    b>Membrane type 4 matrix metalloproteinase (MT4-MMP) shows the least sequence homology to the other MT-MMPs, suggesting a distinct function for this protein...
  46. pmc MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells
    Susan J Atkinson
    Department of Oncology, Cambridge University, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, UK
    Biochem J 398:15-22. 2006
    ....
  47. ncbi Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25)
    W R English
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    FEBS Lett 491:137-42. 2001
    ..Our findings suggest that MT6-MMP could play a role in cellular migration and invasion of the extracellular matrix and basement membranes and its activity may be tightly regulated by all members of the TIMP family...
  48. ncbi Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion
    A M Belkin
    Departments of Biochemistry and Immunology, The Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 276:18415-22. 2001
    ..Proteolysis of adhesion proteins colocalized with MT-MMPs at discrete regions on the surface of migrating tumor cells might be controlled by composition of the surrounding ECM...
  49. pmc Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processes
    Kevin B Hotary
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    J Exp Med 195:295-308. 2002
    ..Given the widespread distribution of MT1-, 2-, and 3-MMP in normal and neoplastic cells, these data identify a subset of membrane-anchored MMPs that operate in an autonomous fashion to drive fibrin-invasive activity...
  50. pmc Screening of novel matrix metalloproteinases (MMPs) in human fetal membranes
    Stephen J Fortunato
    The Perinatal Research Center of The Women s Health Research and Education Foundation, Nashville, Tennessee 37203, USA
    J Assist Reprod Genet 19:483-6. 2002
    ..The objective of this study is to document the expression pattern of most of the MMPs cloned and sequenced so far in amniochorion during preterm premature rupture of membranes (pPROM), at term not in labor and during term labor...
  51. ncbi Expression of membrane type-4 matrix metalloproteinase (metalloproteinase-17) by human eosinophils
    Marie Christine Gauthier
    Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Que, G1V 4G5, Sainte Foy, Canada
    Int J Biochem Cell Biol 35:1667-73. 2003
    ..Consequently, MT4-MMP may be directly involved in the degradation of extracellular matrix components and/or modulate the activity of other proteins implicated in eosinophil migration and tissue remodeling...
  52. ncbi Gene expression analysis of the late embryonic mouse cerebral cortex using DNA microarray: identification of several region- and layer-specific genes
    Nobuo Funatsu
    Department of Cellular Biology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi Kodaira, Tokyo 187 8502, Japan
    Cereb Cortex 14:1031-44. 2004
    ..Our results provide new information about a subclass of regionally expressed genes in the cortical plate at the late embryonic stage, which may help understand the molecular mechanisms of neocortical arealization...
  53. ncbi Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma
    X S Puente
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Oviedo, Spain
    Cancer Res 56:944-9. 1996
    ..On the basis of these expression data in breast tumors, a potential role for human MT4-MMP in the tumoral process is also suggested...
  54. ncbi Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland
    Ludmila Szabova
    Craniofacial and Skeletal Diseases Branch, Matrix Metalloproteinase Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Physiol 205:123-32. 2005
    ..Our results suggest that MT1-MMP, MT2-MMP, and MT3-MMP may be involved in remodeling of both the normal and diseased mammary gland either directly or indirectly by activation of other MMPs...