Gene Symbol: MMP13
Description: matrix metallopeptidase 13
Alias: CLG3, MANDP1, MDST, MMP-13, collagenase 3, matrix metalloproteinase 13 (collagenase 3)
Species: human
Products:     MMP13

Top Publications

  1. Benderdour M, Tardif G, Pelletier J, Dupuis M, Geng C, Martel Pelletier J. A novel negative regulatory element in the human collagenase-3 proximal promoter region. Biochem Biophys Res Commun. 2002;291:1151-9 pubmed
    ..UV cross-linking revealed the presence of 48 and 97 kDa proteins in complex 1 and 27, 35, and 73 kDa proteins in complex 2. These findings suggest that the AGRE site plays a rate-limiting role in human collagenase-3 production. ..
  2. Kim K, Park E, Ju S, Jung H, Bang J, Kim C, et al. Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in interleukin-1beta stimulated fibroblast-like synoviocytes. Arthritis Res Ther. 2007;9:R80 pubmed
  3. Johnson A, Pavlovsky A, Ortwine D, Prior F, Man C, Bornemeier D, et al. Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. J Biol Chem. 2007;282:27781-91 pubmed
    Matrix metalloproteinase-13 (MMP13) is a Zn(2+)-dependent protease that catalyzes the cleavage of type II collagen, the main structural protein in articular cartilage...
  4. Freije J, Diez Itza I, Balbin M, Sanchez L, Blasco R, Tolivia J, et al. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J Biol Chem. 1994;269:16766-73 pubmed
    ..On the basis of the increased expression of collagenase-3 in breast carcinomas and the absence of detectable expression in normal tissues, a possible role for this metalloproteinase in the tumoral process is proposed. ..
  5. Sakao K, Takahashi K, Arai Y, Saito M, Honjo K, Hiraoka N, et al. Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis. J Bone Miner Metab. 2009;27:412-23 pubmed publisher
    ..By controlling the expression of these genes in the osteophytes, the progression of cartilage degeneration in OA may be reduced, suggesting a new treatment strategy for OA. ..
  6. Tannure P, Küchler E, Falagan Lotsch P, Amorim L, Raggio Luiz R, Costa M, et al. MMP13 polymorphism decreases risk for dental caries. Caries Res. 2012;46:401-7 pubmed publisher
    ..The purpose of this study was to determine if polymorphisms in MMP2 (rs243865), MMP9 (rs17576), MMP13 (rs2252070), and TIMP2 (rs7501477) were associated with caries...
  7. Takaishi H, Kimura T, Dalal S, Okada Y, D ARMIENTO J. Joint diseases and matrix metalloproteinases: a role for MMP-13. Curr Pharm Biotechnol. 2008;9:47-54 pubmed
    ..This review describes a body of research that supports the development of novel selective MMP-13 inhibitors with the hope of developing these compounds in clinical trials for the treatment of arthritis. ..
  8. Knauper V, Cowell S, Smith B, Lopez Otin C, O SHEA M, Morris H, et al. The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction. J Biol Chem. 1997;272:7608-16 pubmed
    ..TIMP-2/C.TIMP-1 by a factor of up to 33. In contrast, the association rates for complex formation with TIMP-2 and N.TIMP-1/C.TIMP-2 were only marginally affected by C-terminal domain interactions. ..
  9. Akhtar N, Rasheed Z, Ramamurthy S, Anbazhagan A, Voss F, Haqqi T. MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum. 2010;62:1361-71 pubmed publisher
    ..Thus, miR-27b may play a role in regulating the expression of MMP-13 in human chondrocytes. ..

More Information


  1. Hou C, Hsiao Y, Fong Y, Tang C. Bone morphogenetic protein-2 enhances the motility of chondrosarcoma cells via activation of matrix metalloproteinase-13. Bone. 2009;44:233-42 pubmed publisher
    ..Taken together, our results indicated that BMP-2 enhanced the invasiveness of chondrosarcoma cells by increasing MMP-13 expression through the PI3K, Akt, c-Fos/c-Jun and AP-1 signal transduction pathway. ..
  2. Ikeda K, Ihara K, Yamaguchi K, Muneuchi J, Ohno T, Mizuno Y, et al. Genetic analysis of MMP gene polymorphisms in patients with Kawasaki disease. Pediatr Res. 2008;63:182-5 pubmed
    ..There was no association between other MMP genes and CAL formation. In conclusion, the genetic evaluation by association study demonstrated that the MMP-13 gene, at least in part, contributed to the development of CALs in KD. ..
  3. Wang J, Li X, Gao X, An S, Liu H, Liang J, et al. Expression of MMP-13 is associated with invasion and metastasis of papillary thyroid carcinoma. Eur Rev Med Pharmacol Sci. 2013;17:427-35 pubmed
    ..The data suggest that MMP-13 is associated with thyroid tumour invasion and metastasis and it may be a potential target for therapeutic intervention. ..
  4. Knauper V, Will H, Lopez Otin C, Smith B, Atkinson S, Stanton H, et al. Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme. J Biol Chem. 1996;271:17124-31 pubmed
    ..This new activation cascade may be significant in human breast cancer pathology, where all three enzymes have been implicated as playing important roles. ..
  5. Sulkala M, Pääkkönen V, Larmas M, Salo T, Tjäderhane L. Matrix metalloproteinase-13 (MMP-13, collagenase-3) is highly expressed in human tooth pulp. Connect Tissue Res. 2004;45:231-7 pubmed
    ..Further studies with a larger sample size are needed to clarify the changes in MMP-13 expression during caries progression. ..
  6. Mäkinen L, Häyry V, Atula T, Haglund C, Keski Säntti H, Leivo I, et al. Prognostic significance of matrix metalloproteinase-2, -8, -9, and -13 in oral tongue cancer. J Oral Pathol Med. 2012;41:394-9 pubmed publisher
    ..017) and tumor size (P = 0.008). Furthermore, high nuclear MMP-13 expression was predictive of poor outcome (P = 0.042). Our results suggest that especially MMP-13 may be regarded as a prognostic biomarker in OTSCC. ..
  7. Toriseva M, Ala aho R, Karvinen J, Baker A, Marjomäki V, Heino J, et al. Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts. J Invest Dermatol. 2007;127:49-59 pubmed
  8. Zhang B, Cao X, Liu Y, Cao W, Zhang F, Zhang S, et al. Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer. BMC Cancer. 2008;8:83 pubmed publisher
    ..MMP-13 may serve as an independent prognostic factor for invasive breast cancer patients. MMP-13 may be particularly useful as a prognostic marker when evaluated along with Her-2/neu and lymph node status. ..
  9. Knauper V, Lopez Otin C, Smith B, Knight G, Murphy G. Biochemical characterization of human collagenase-3. J Biol Chem. 1996;271:1544-50 pubmed
    ..These results suggest that in vivo collagenase-3 could play a significant role in the turnover of connective tissue matrix constituents. ..
  10. Lei H, Hemminki K, Altieri A, Johansson R, Enquist K, Hallmans G, et al. Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. Breast Cancer Res Treat. 2007;103:61-9 pubmed
    ..In this, so far largest case-control study, we genotyped eight SNPs in the MMP1, MMP2, MMP3, MMP9, MMP13, RECK and TIMP3 genes in a well-characterized breast cancer series of 959 cases and 952 controls from Sweden...
  11. Yu T, Wu Y, Helman J, Wen Y, Wang C, Li L. CXCR4 promotes oral squamous cell carcinoma migration and invasion through inducing expression of MMP-9 and MMP-13 via the ERK signaling pathway. Mol Cancer Res. 2011;9:161-72 pubmed publisher
    ..Taken together, our results strongly suggest the underlying mechanism of CXCR4 promoting Tca8113 migration and invasion by regulating MMP-9 and MMP-13 expression perhaps via activation of the ERK signaling pathway. ..
  12. Corte M, Gonzalez L, Corte M, Quintela I, Pidal I, Bongera M, et al. Collagenase-3 (MMP-13) expression in cutaneous malignant melanoma. Int J Biol Markers. 2005;20:242-8 pubmed
    ..One specific MMP, collagenase-3 (MMP-13), is thought to have a key function in the activation of MMP...
  13. Leeman M, Curran S, Murray G. The structure, regulation, and function of human matrix metalloproteinase-13. Crit Rev Biochem Mol Biol. 2002;37:149-66 pubmed
    ..This commentary provides a detailed overview of the regulatory mechanisms, structure, and function of human MMP-13 and highlights the key factors involved in the biology of this important molecule. ..
  14. Blaney Davidson E, Remst D, Vitters E, van Beuningen H, Blom A, Goumans M, et al. Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. J Immunol. 2009;182:7937-45 pubmed publisher
    ..Our data suggest that dominant ALK1 signaling results in deviant chondrocyte behavior, thereby contributing to age-related cartilage destruction and OA. ..
  15. Yammani R, Long D, Loeser R. Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum. 2009;60:792-800 pubmed publisher
    ..Since both IL-7 and S100A4 are up-regulated in OA cartilage and can stimulate MMP-13 production by chondrocytes, this signaling pathway could contribute to cartilage destruction during the development of OA. ..
  16. Pendas A, Balbin M, Llano E, Jiménez M, Lopez Otin C. Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13). Genomics. 1997;40:222-33 pubmed
    Human collagenase-3 (MMP13) is a recently identified member of the matrix metalloproteinase (MMP) family that is expressed in breast carcinomas and in articular cartilage from arthritic patients...
  17. Leonardi R, Loreto C, Barbato E, Caltabiano R, Lombardo C, Musumeci G, et al. MMP-13 (collagenase 3) localization in human temporomandibular joint discs with internal derangement. Acta Histochem. 2008;110:314-8 pubmed publisher
    ..A well-characterized mouse monoclonal anti-MMP-13 antibody (anti-collagenase 3) was used...
  18. Ohno S, Im H, Knudson C, Knudson W. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. J Biol Chem. 2006;281:17952-60 pubmed
    ..Our findings suggest that hyaluronan-CD44 interactions affect matrix metabolism via activation of NFkappaB and p38 MAP kinase. ..
  19. Yoon S, Kuivaniemi H, Gatalica Z, Olson J, Buttice G, Ye S, et al. MMP13 promoter polymorphism is associated with atherosclerosis in the abdominal aorta of young black males. Matrix Biol. 2002;21:487-98 pubmed
    ..We investigated the importance of matrix metalloproteinase 13 (MMP13), in the pathogenesis of atherosclerosis using 995 samples from the Pathobiological Determinants of ..
  20. Yang B, Gao J, Rao Z, Shen Q. Clinicopathological significance and prognostic value of MMP-13 expression in colorectal cancer. Scand J Clin Lab Invest. 2012;72:501-5 pubmed publisher
    ..452, p <?0.001). Collectively, we found that MMP-13 was correlated with progression and metastasis of CRC and could be used as a prognostic marker in CRC. ..
  21. McQuibban G, Gong J, Tam E, McCulloch C, Clark Lewis I, Overall C. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science. 2000;289:1202-6 pubmed
    ..This suggests that matrix metalloproteinases are both effectors and regulators of the inflammatory response. ..
  22. Lauer Fields J, Tuzinski K, Shimokawa K, Nagase H, Fields G. Hydrolysis of triple-helical collagen peptide models by matrix metalloproteinases. J Biol Chem. 2000;275:13282-90 pubmed
  23. Lu D, Leung Y, Cheung C, Chen Y, Wong K. Glial cell line-derived neurotrophic factor induces cell migration and matrix metalloproteinase-13 expression in glioma cells. Biochem Pharmacol. 2010;80:1201-9 pubmed publisher
    ..These results indicate that GDNF enhances migration of glioma cells through the increase of MMP-13 production and is mainly regulated by the MEK/ERK and JNK, c-Jun and AP-1 pathways. ..
  24. Zhou G, Zhai Y, Cui Y, Qiu W, Yang H, Zhang X, et al. Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma. Hum Mutat. 2007;28:1091-7 pubmed
    ..Eight polymorphisms in the promoter of MMP1, MMP2, MMP3, MMP7, MMP9, MMP12, and MMP13 were genotyped in two independent case-control populations; one is from Guangxi province (593 patients with NPC ..
  25. Mitchell P, Magna H, Reeves L, Lopresti Morrow L, Yocum S, Rosner P, et al. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest. 1996;97:761-8 pubmed
  26. Im H, Muddasani P, Natarajan V, Schmid T, Block J, Davis F, et al. Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes. J Biol Chem. 2007;282:11110-21 pubmed
    ..We propose that deregulation of cross-talk between MAPK and PKCdelta signaling may contribute to the etiology of osteoarthritis in human patients. ..
  27. Inoue A, Takahashi H, Harada H, Kohno S, Ohue S, Kobayashi K, et al. Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity. Int J Oncol. 2010;37:1121-31 pubmed
    ..The results suggest that the highly invasive potential of cancer stem cells depends on MMP-13 enzymatic activity, thus MMP-13 might be a potential therapeutic target for glioblastomas. ..
  28. Yammani R, Carlson C, Bresnick A, Loeser R. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. Arthritis Rheum. 2006;54:2901-11 pubmed
    ..Since both S100A4 and RAGE are up-regulated in OA cartilage, this signaling pathway could contribute to cartilage degradation in OA. ..
  29. Farshchian M, Nissinen L, Siljamäki E, Riihilä P, Piipponen M, Kivisaari A, et al. Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma. Oncotarget. 2017;8:45825-45836 pubmed publisher
    ..resulted in reduction in invasion of cSCC cells and downregulation in production of invasion proteinases MMP1 and MMP13. Knockdown of AIM2 resulted in suppression of growth and vascularization of cSCC xenografts in vivo...
  30. Davelaar A, Straub D, Buttar N, Fockens P, Krishnadath K. Active matrix metalloproteases are expressed early on and are high during the Barrett's esophagus malignancy sequence. Scand J Gastroenterol. 2015;50:321-32 pubmed publisher
    ..esophagus and esophageal adenocarcinoma patient biopsies and was further differentiated by investigating MMP9 and MMP13 expressions...
  31. Yong H, Kim I, Kim J, Moon A. ErbB2-enhanced invasiveness of H-Ras MCF10A breast cells requires MMP-13 and uPA upregulation via p38 MAPK signaling. Int J Oncol. 2010;36:501-7 pubmed
  32. Grootaert M, Schrijvers D, Van Spaendonk H, Breynaert A, Hermans N, Van Hoof V, et al. NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice. Atherosclerosis. 2016;252:166-174 pubmed publisher the aortic root of NecroX-7-treated mice showed a significant decrease in necrotic core area, 8-oxodG, iNOS and MMP13 expression, while collagen content and minimum fibrous cap thickness were increased...
  33. Izawa T, Mori H, Shinohara T, Mino Oka A, Hutami I, Iwasa A, et al. Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis. PLoS ONE. 2016;11:e0154107 pubmed publisher
  34. Lizarbe T, Tarin C, Gomez M, Lavin B, Aracil E, Orte L, et al. Nitric oxide induces the progression of abdominal aortic aneurysms through the matrix metalloproteinase inducer EMMPRIN. Am J Pathol. 2009;175:1421-30 pubmed publisher
    ..Our results suggest that NO may regulate the development of AAA in part by inducing the expression of EMMPRIN and modulating the activity of MMP-13 in murine and human aneurysms. ..
  35. Gao H, Song Y, Li D, Feng W, Liu J. Saikosaponin A inhibits IL-1?-induced inflammatory mediators in human osteoarthritis chondrocytes by activating LXR?. Oncotarget. 2017;8:88941-88950 pubmed publisher
    ..The production of PGE2 and NO were detected by ELISA and Griess method. The levels of MMP1, MMP3, and MMP13 were measured by ELISA and qRT-PCR. The expression of NF-?B and LXR? were tested by western blot analysis...
  36. Achari Y, Lu T, Katzenellenbogen B, Hart D. Distinct roles for AF-1 and -2 of ER-alpha in regulation of MMP-13 promoter activity. Biochim Biophys Acta. 2009;1792:211-20 pubmed publisher
    ..As ER variants and ER related proteins have been implicated in bone and joint disorders, these findings provide understanding of the possible role of ER variants in the development of such conditions. ..
  37. Kubota K, Tsuchihashi Y, Kogure T, Maeyama K, Hattori F, Kinoshita S, et al. Structural and functional analyses of a TIMP and MMP in the ligament of Pinctada fucata. J Struct Biol. 2017;199:216-224 pubmed publisher
    ..PfTIMP strongly inhibited human MMP13 and MMP9. Eight MMP homologs were identified from a P. fucata genomic database by BLAST search...
  38. Wang X, Ning Y, Yang L, Yu F, Guo X. Zinc: the Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium. Biol Trace Elem Res. 2017;179:178-184 pubmed publisher
    ..forms a catabolic cascade that promotes upregulation of the crucial effector matrix-degrading enzymes MMP3, MMP13, and ADAMTS5, thereby leading to osteoarthritis (OA) cartilage destruction...
  39. Liao S, Zhou K, Li D, Xie X, Jun F, Wang J. Schisantherin A suppresses interleukin-1?-induced inflammation in human chondrocytes via inhibition of NF-?B and MAPKs activation. Eur J Pharmacol. 2016;780:65-70 pubmed publisher
    ..The production of MMP-1, MMP3, MMP13 were measured by ELISA. The expression of NF-?B and MAPKs were detected by western blotting...
  40. Sawada Y, Sugimoto A, Hananouchi T, Sato N, Nagaoka I. Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double-blind, placebo-controlled study. Exp Ther Med. 2017;14:4561-4571 pubmed publisher
    ..Therefore, ADE could be a promising candidate as a functional food that is beneficial to joint health...
  41. Alexander K, Banos A, Abro S, Hoppensteadt D, Fareed J, Rees H, et al. Levels of Matrix Metalloproteinases in Arthroplasty Patients and Their Correlation With Inflammatory and Thrombotic Activation Processes. Clin Appl Thromb Hemost. 2016;22:441-6 pubmed publisher
    ..Tissue inhibitor of MMP 4, tumor necrosis factor ? (TNF-?), pro-MMP1, MMP3, MMP9, MMP13, and d-dimer were measured using enzyme-linked immunosorbent assay kits...
  42. Li T, Xiao J, Wu Z, Qiu G, Ding Y. Transcriptional activation of human MMP-13 gene expression by c-Maf in osteoarthritic chondrocyte. Connect Tissue Res. 2010;51:48-54 pubmed publisher
    ..By gene suppression with RNAi technology, we could show that c-maf downregulation leads to a reduced expression of MMP13. Chromatin immunoprecipitation assays reveal that c-maf binds to the MMP-13 gene promoter to a region of the MMP-..
  43. Cheung R, Erclik M, Mitchell J. Increased expression of G11alpha in osteoblastic cells enhances parathyroid hormone activation of phospholipase C and AP-1 regulation of matrix metalloproteinase-13 mRNA. J Cell Physiol. 2005;204:336-43 pubmed
    ..This leads to increased PTH stimulation of MMP-13 expression by increased stimulation of AP-1 factors c-jun and c-fos. ..
  44. Xu L, Sun K, Xia M, Li X, Lu Y. MMP13 Regulates Aggressiveness of Pediatric Multiple Myeloma Through VEGF-C. Cell Physiol Biochem. 2015;36:509-16 pubmed publisher
    ..Here we studied vascular endothelial growth factor C (VEGF-C) and matrix metalloproteinase 13 (MMP13) in pediatric MM patients...
  45. Chang S, Yasui T, Taketomi S, Matsumoto T, Kim Kaneyama J, Omiya T, et al. Comparison of mouse and human ankles and establishment of mouse ankle osteoarthritis models by surgically-induced instability. Osteoarthritis Cartilage. 2016;24:688-97 pubmed publisher
    ..dUTP nick end labeling (TUNEL) staining and Adamts5 expression were enhanced at early and middle stages, while Mmp13 expression was gradually increased during the OA development...
  46. Yin L, Motz K, Samad I, Duvvuri M, Murphy M, Ding D, et al. Fibroblasts in Hypoxic Conditions Mimic Laryngotracheal Stenosis. Otolaryngol Head Neck Surg. 2017;156:886-892 pubmed publisher
    ..8, P < .01), myofibroblast marker αSMA (fold change = 3.0, P = .01), and MMP13 (fold change = 5.4, P = .02) was significantly increased in scar biopsy samples as compared to normal...
  47. Filomia F, Saxena P, Durante C, De Rienzo F, Cocchi M, Menziani M. Computational Insights into ADAMTS4, ADAMTS5 and MMP13 Inhibitor Selectivity. Mol Inform. 2012;31:421-30 pubmed publisher
    ..obtained by means of Molecular Dynamics simulations and Multiway Explorative Data Analysis on ADAMTS4, ADAMTS5 and MMP13 complexed with Marimastat and two cis-1(S)2(R)-amino-2-indanol ligands suggest that determinant characteristics ..
  48. Novotný T, Krejčí J, Malíková J, Švehlík V, Wasserbauer R, Uhlík J, et al. Mast cell stabilization with sodium cromoglycate modulates pulmonary vessel wall remodeling during four-day hypoxia in rats. Exp Lung Res. 2015;41:283-92 pubmed publisher
    ..Such remodeling changes are not mediated by mast cell products only since they have occurred in spite of stabilization of mast cell granules. ..
  49. Tao Y, Sun H, Sun H, Qiu X, Xu C, Shi C, et al. 17β-estradiol activates mTOR in chondrocytes by AKT-dependent and AKT-independent signaling pathways. Int J Clin Exp Pathol. 2015;8:15911-8 pubmed
    ..Matrix metallopeptidase (MMP) 3 or MMP13 mRNA levels were evaluated by quantitative real-time PCR (qRT-PCR)...
  50. Akhavan M, Karimi M, Ghodrati M, Falahtpishe H. AT1 receptors activation enhances the expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 melanoma cells. Pak J Biol Sci. 2011;14:821-30 pubmed
    ..This is an important conclusion because of the importance of these factors in melanoma invasiveness and the possible important role that angiotensin receptor blockers may play as cancer medications. ..
  51. Liu Z, Li C, Meng X, Bai Y, Qi J, Wang J, et al. Hypoxia-inducible factor-l? mediates aggrecan and collagen ? expression via NOTCH1 signaling in nucleus pulposus cells during intervertebral disc degeneration. Biochem Biophys Res Commun. 2017;488:554-561 pubmed publisher
    ..the HIF-1?-NOTCH1 pathway altered ECM turnover by suppressing expression of the matrix metalloproteinases MMP1 and MMP13, while increasing the expression of tissue inhibitor of metalloproteinase-1 (TIMP1)...
  52. Kauwe J, Bailey M, Ridge P, Perry R, Wadsworth M, Hoyt K, et al. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. PLoS Genet. 2014;10:e1004758 pubmed publisher
    ..Robust associations in cognitively normal individuals suggest that these SNPs also influence regulation of these proteins more generally and may therefore be relevant to other diseases. ..
  53. Costa B, Gonçalves A, Abrantes A, Matafome P, Seica R, Sarmento Ribeiro A, et al. Teduglutide effects on gene regulation of fibrogenesis on an animal model of intestinal anastomosis. J Surg Res. 2017;216:87-98 pubmed publisher
    ..type 1 alpha 1, Collagen type 3 alpha 1, and Collagen type 4 alpha 1, Timp1, and Timp2 and downregulation of Mmp13 and to a net degradation of collagen at the seventh day, derived from repression of Collagen type 3 alpha 1, ..
  54. Ouyang J, Jiang H, Fang H, Cui W, Cai D. Isoimperatorin ameliorates osteoarthritis by downregulating the mammalian target of rapamycin C1 signaling pathway. Mol Med Rep. 2017;16:9636-9644 pubmed publisher
    ..The mRNA expression levels of MMP13, Runx2, Col X and VEGF were determined by reverse transcription?quantitative polymerase chain reaction...
  55. Hayami T, Kapila Y, Kapila S. Divergent upstream osteogenic events contribute to the differential modulation of MG63 cell osteoblast differentiation by MMP-1 (collagenase-1) and MMP-13 (collagenase-3). Matrix Biol. 2011;30:281-9 pubmed publisher
    ..These data show that MMP-1's and -13's differential regulation of osteoblastic markers in MG63 cells likely results from their modulation of divergent signaling pathways involved in osteoblastic differentiation. ..
  56. Rodriguez Lopez J, Perez Pampin E, Gomez Reino J, Gonzalez A. Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study. Arthritis Res Ther. 2006;8:R1 pubmed, including SNPs in the genes encoding matrix metalloproteinase (MMP)1, MMP2, MMP3, MMP7, MMP9, MMP13, plasminogen activator, tissue type (PLAT) and PAI-1...
  57. Wu Y, Wu T, Xu B, Xu X, Chen H, Li X. Oxytocin prevents cartilage matrix destruction via regulating matrix metalloproteinases. Biochem Biophys Res Commun. 2017;486:601-606 pubmed publisher
    ..Our study implied the therapeutic potential of OT for cartilage degradation. ..
  58. Shih Y, Au M, Liu K, Yeh M, Lee C, Lee M, et al. Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017;32:2400-2413 pubmed publisher
    ..TGFBR3, SHC3 and MAP2K6 metastasis-related genes were increased, but CCND1, JUN, CDKN1A, TGFB1, 2 and 3, SMAD4, MMP13, MMP2 and FN1 genes were decreased...
  59. Cuadrado E, Rosell A, Borrell Pages M, Garcia Bonilla L, Hernandez Guillamon M, Ortega Aznar A, et al. Matrix metalloproteinase-13 is activated and is found in the nucleus of neural cells after cerebral ischemia. J Cereb Blood Flow Metab. 2009;29:398-410 pubmed publisher
    ..Nuclear extracts from cells confirmed upregulation of active MMP-13 after OGD (P<0.05). These results suggest that MMP-13 activation and its nuclear translocation is an early consequence of an ischemic stimulus. ..
  60. Akkiraju H, Bonor J, Nohe A. CK2.1, a novel peptide, induces articular cartilage formation in vivo. J Orthop Res. 2017;35:876-885 pubmed publisher
    ..b>MMP13 expression was unchanged. Our study demonstrates that CK2...
  61. Jiang H, Gao Q, Che X, Zhu L, Zhang Z, Chen Y, et al. Inhibition of penile tunica albuginea myofibroblasts activity by adipose-derived stem cells. Exp Ther Med. 2017;14:5149-5156 pubmed publisher
    ..the MFs+ADSCs group compared with that in the MFs-only culture, while the expression of MMPs (MMP2, MMP3, MMP9 and MMP13) and caspases (caspase3 and caspase9) was upregulated...
  62. Miyamoto K, Ohkawara B, Ito M, Masuda A, Hirakawa A, Sakai T, et al. Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/?-catenin signaling. PLoS ONE. 2017;12:e0184388 pubmed publisher
    ..the chondrogenic master regulator), and decreased expressions of Axin2 (a marker for Wnt/?-catenin signaling) and Mmp13 (matrix metalloproteinase 13)...
  63. Nakatani T, Partridge N. MEF2C Interacts With c-FOS in PTH-Stimulated Mmp13 Gene Expression in Osteoblastic Cells. Endocrinology. 2017;158:3778-3791 pubmed publisher
    Parathyroid hormone (PTH) regulates the transcription of many genes in the osteoblast. One of these genes is Mmp13, which is involved in bone remodeling and early stages of endochondral bone formation...
  64. Tsai C, Yeh W, Chen J, Lin C, Huang S, Lu D. Osthole suppresses the migratory ability of human glioblastoma multiforme cells via inhibition of focal adhesion kinase-mediated matrix metalloproteinase-13 expression. Int J Mol Sci. 2014;15:3889-903 pubmed publisher
    ..This study also provides evidence supporting the potential of osthole in reducing FAK activation, MMP-13 expression, and cell motility in human GBM cells. ..
  65. Hernandez P, Buller D, Mitchell T, Wright J, Liang H, Manchanda K, et al. Severe Burn-Induced Inflammation and Remodeling of Achilles Tendon in a Rat Model. Shock. 2017;: pubmed publisher
    ..We analyzed tendons for changes in expression of IL-6, IL-1?, TNF, MMP9, MMP13, TGF?1, Collagens I and III, and for morphological and biomechanical changes...
  66. Jia J, Kang S, Zhao J, Zhang X, Wang N, Zhou R, et al. [Association of functional polymorphisms on MMP-12 and MMP-13 gene promoter region with epithelial ovarian carcinoma]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010;27:209-13 pubmed publisher
    ..06). These results suggested that individuals with MMP-12 -82A/G and MMP-13 -77A/A might have higher risk of overall or special histological type of EOC development. ..
  67. Wang Z, Huang J, Zhou S, Luo F, Xu W, Wang Q, et al. Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1?/NF-?B pathway. J Cell Mol Med. 2017;21:3231-3243 pubmed publisher
    ..ANE decreased the expressions of matrix metalloproteinase-13 (MMP13), A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5), collagen X (Col X) while increasing ..
  68. Kominsky S, Doucet M, Thorpe M, Weber K. MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1. Clin Exp Metastasis. 2008;25:865-70 pubmed publisher
    ..These data suggest that MMP-13 expression is elevated in RBM relative to primary RCC and adjacent normal kidney, and is regulated at the cellular level by TGF-beta1. ..
  69. Wu M, Lo J, Kuo C, Lin J, Lin Y, Chen L, et al. Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways. J Cell Physiol. 2012;227:3016-26 pubmed publisher
    ..Taken together, these results suggest that ET-1 activated FAK/PI3K/AKT/mTOR, which in turn activated IKK?/? and NF-?B, resulting in increased MMP-13 expression and migration in human chondrosarcoma cells...
  70. Wang C, Jin G, Jin H, Wang N, Luo Q, Zhang Y, et al. Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma. Oncotarget. 2015;6:2903-16 pubmed
    ..eukaryotic translation initiation factor 3 subunit I (EIF3I), which in turn promoted matrix metalloproteinase 13 (MMP13) expression and HCC metastasis...
  71. Nara H, Sato K, Kaieda A, Oki H, Kuno H, Santou T, et al. Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors. Bioorg Med Chem. 2016;24:6149-6165 pubmed publisher
    ..In this article, the design, synthesis, and biological activity of novel zinc-binding MMP-13 inhibitors are described. ..
  72. Nakatani T, Chen T, Partridge N. MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton. Bone. 2016;90:142-51 pubmed publisher
    ..Previously, we reported that Hdac4 is a repressor of matrix metalloproteinase-13 (Mmp13) transcription, and the absence of Hdac4 leads to increased expression of MMP-13 both in vitro (osteoblastic cells)..
  73. Datta P, Zhang Y, Parousis A, Sharma A, Rossomacha E, Endisha H, et al. High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature. Sci Rep. 2017;7:8205 pubmed publisher
    ..Leptin-induced increased MMP13 expression was reversed by autotaxin inhibition...
  74. Chen W, Yang Z, Hu P, Bao J, Wu L. Acacetin inhibits expression of matrix metalloproteinases via a MAPK-dependent mechanism in fibroblast-like synoviocytes. J Cell Mol Med. 2015;19:1910-5 pubmed publisher
    ..Our results suggest that acacetin has antiarthritic effects in FLSs. Thus, acacetin should be further studied for the treatment of arthritis. ..
  75. Roy Beaudry M, Martel Pelletier J, Pelletier J, M Barek K, Christgau S, Shipkolye F, et al. Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction. Arthritis Rheum. 2003;48:2855-64 pubmed
    ..Hence, ET-1 becomes an attractive factor to target in the conception of new therapeutic approaches for OA and other diseases in which MMP-13 and MMP-1 actions are crucial in tissue alteration. ..
  76. Yu Q, Cok S, Zeng C, Morrison A. Translational repression of human matrix metalloproteinases-13 by an alternatively spliced form of T-cell-restricted intracellular antigen-related protein (TIAR). J Biol Chem. 2003;278:1579-84 pubmed
    ..In addition to the 3'-untranslated region of the matrix metalloproteinases-13 (MMP13) gene, the differential expression of an alternatively spliced transcript of the RNA-binding protein TIAR in human ..