MMP12

Summary

Gene Symbol: MMP12
Description: matrix metallopeptidase 12
Alias: HME, MME, MMP-12, macrophage metalloelastase, matrix metallopeptidase 12 (macrophage elastase), matrix metalloproteinase 12 (macrophage elastase)
Species: human
Products:     MMP12

Top Publications

  1. Joos L, He J, Shepherdson M, Connett J, Anthonisen N, Pare P, et al. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Hum Mol Genet. 2002;11:569-76 pubmed
    ..MMP1 (interstitial collagenase), MMP9 (gelatinase B) and MMP12 (macrophage elastase) are thought to be important in the development of emphysema...
  2. Souissi I, Billiet L, Cuaz Pérolin C, Slimane M, Rouis M. Matrix metalloproteinase-12 gene regulation by a PPAR alpha agonist in human monocyte-derived macrophages. Exp Cell Res. 2008;314:3405-14 pubmed publisher
  3. Zhang R, He Q, Yang R, Lu B, Liu Y. [Study on matrix metalloproteinase 1, 9, 12 polymorphisms and susceptibility to chronic obstructive pulmonary disease among Han nationality in northern China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2005;26:907-10 pubmed
    ..b>MMP12 Asn/Asn, CT/AsnAsn were risk factors for smoking-induced COPD. The ORs were 2.361 (95% CI: 1.369-4.017) and 2...
  4. Zhang B, Dhillon S, Geary I, Howell W, Iannotti F, Day I, et al. Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage. Stroke. 2001;32:2198-202 pubmed
    ..The data do not support the hypothesis that MMP gene variations influence the development of intracranial aneurysms in the population studied. ..
  5. Hunninghake G, Cho M, Tesfaigzi Y, Soto Quiros M, Avila L, Lasky Su J, et al. MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009;361:2599-608 pubmed publisher
    ..an association between single-nucleotide polymorphisms (SNPs) in the gene encoding matrix metalloproteinase 12 (MMP12) and a measure of lung function (prebronchodilator forced expiratory volume in 1 second [FEV(1)]) in more than ..
  6. Ng K, Qi X, Kong K, Cheung B, Lo C, Poon R, et al. Overexpression of matrix metalloproteinase-12 (MMP-12) correlates with poor prognosis of hepatocellular carcinoma. Eur J Cancer. 2011;47:2299-305 pubmed publisher
    ..Our data demonstrated that MMP-12 mRNA may be a valuable prognostic marker for both overall survival and tumour recurrence of HCC patients after liver resection. ..
  7. Shapiro S, Kobayashi D, Ley T. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J Biol Chem. 1993;268:23824-9 pubmed
    ..J. (1992) J. Biol. Chem. 267, 4664-4671). We now report that there is a human orthologue of murine macrophage metalloelastase that we call human macrophage metalloelastase (HME). The full-length HME cDNA spans 1...
  8. McAloon C, Wood A, Gough S, Stockley R. Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency. Ther Adv Respir Dis. 2009;3:23-30 pubmed publisher
    ..to assess the role of polymorphism of MMP1, MMP3 and MMP12 in AATD phenotypes...
  9. Nar H, Werle K, Bauer M, Dollinger H, Jung B. Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor. J Mol Biol. 2001;312:743-51 pubmed
    ..The present structure enables us to aid the design of potent and selective inhibitors for MMP-12. ..
  10. Motterle A, Xiao Q, Kiechl S, Pender S, Morris G, Willeit J, et al. Influence of matrix metalloproteinase-12 on fibrinogen level. Atherosclerosis. 2012;220:351-4 pubmed publisher
    In vitro studies have shown that matrix metalloproteinase-12 (MMP12) can degrade fibrinogen, a clotting factor whose level predicts risk of advanced atherosclerosis and myocardial infarction...

Detail Information

Publications96

  1. Joos L, He J, Shepherdson M, Connett J, Anthonisen N, Pare P, et al. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Hum Mol Genet. 2002;11:569-76 pubmed
    ..MMP1 (interstitial collagenase), MMP9 (gelatinase B) and MMP12 (macrophage elastase) are thought to be important in the development of emphysema...
  2. Souissi I, Billiet L, Cuaz Pérolin C, Slimane M, Rouis M. Matrix metalloproteinase-12 gene regulation by a PPAR alpha agonist in human monocyte-derived macrophages. Exp Cell Res. 2008;314:3405-14 pubmed publisher
  3. Zhang R, He Q, Yang R, Lu B, Liu Y. [Study on matrix metalloproteinase 1, 9, 12 polymorphisms and susceptibility to chronic obstructive pulmonary disease among Han nationality in northern China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2005;26:907-10 pubmed
    ..b>MMP12 Asn/Asn, CT/AsnAsn were risk factors for smoking-induced COPD. The ORs were 2.361 (95% CI: 1.369-4.017) and 2...
  4. Zhang B, Dhillon S, Geary I, Howell W, Iannotti F, Day I, et al. Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage. Stroke. 2001;32:2198-202 pubmed
    ..The data do not support the hypothesis that MMP gene variations influence the development of intracranial aneurysms in the population studied. ..
  5. Hunninghake G, Cho M, Tesfaigzi Y, Soto Quiros M, Avila L, Lasky Su J, et al. MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009;361:2599-608 pubmed publisher
    ..an association between single-nucleotide polymorphisms (SNPs) in the gene encoding matrix metalloproteinase 12 (MMP12) and a measure of lung function (prebronchodilator forced expiratory volume in 1 second [FEV(1)]) in more than ..
  6. Ng K, Qi X, Kong K, Cheung B, Lo C, Poon R, et al. Overexpression of matrix metalloproteinase-12 (MMP-12) correlates with poor prognosis of hepatocellular carcinoma. Eur J Cancer. 2011;47:2299-305 pubmed publisher
    ..Our data demonstrated that MMP-12 mRNA may be a valuable prognostic marker for both overall survival and tumour recurrence of HCC patients after liver resection. ..
  7. Shapiro S, Kobayashi D, Ley T. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J Biol Chem. 1993;268:23824-9 pubmed
    ..J. (1992) J. Biol. Chem. 267, 4664-4671). We now report that there is a human orthologue of murine macrophage metalloelastase that we call human macrophage metalloelastase (HME). The full-length HME cDNA spans 1...
  8. McAloon C, Wood A, Gough S, Stockley R. Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency. Ther Adv Respir Dis. 2009;3:23-30 pubmed publisher
    ..to assess the role of polymorphism of MMP1, MMP3 and MMP12 in AATD phenotypes...
  9. Nar H, Werle K, Bauer M, Dollinger H, Jung B. Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor. J Mol Biol. 2001;312:743-51 pubmed
    ..The present structure enables us to aid the design of potent and selective inhibitors for MMP-12. ..
  10. Motterle A, Xiao Q, Kiechl S, Pender S, Morris G, Willeit J, et al. Influence of matrix metalloproteinase-12 on fibrinogen level. Atherosclerosis. 2012;220:351-4 pubmed publisher
    In vitro studies have shown that matrix metalloproteinase-12 (MMP12) can degrade fibrinogen, a clotting factor whose level predicts risk of advanced atherosclerosis and myocardial infarction...
  11. Kim J, Kim H, Koo B, Rha K, Yoon Y. Expression of matrix metalloproteinase-12 is correlated with extracapsular spread of tumor from nodes with metastasis in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2013;270:1137-42 pubmed publisher
    ..024, 0.011). No relation was found between MMP expression and survival. MMP-12 expressed in the primary tumor is a molecular marker that may be useful for predicting ECS in HNSCC patients with metastatic nodal disease. ..
  12. Ikeda K, Ihara K, Yamaguchi K, Muneuchi J, Ohno T, Mizuno Y, et al. Genetic analysis of MMP gene polymorphisms in patients with Kawasaki disease. Pediatr Res. 2008;63:182-5 pubmed
    ..There was no association between other MMP genes and CAL formation. In conclusion, the genetic evaluation by association study demonstrated that the MMP-13 gene, at least in part, contributed to the development of CALs in KD. ..
  13. Babusyte A, Stravinskaite K, Jeroch J, Lotvall J, Sakalauskas R, Sitkauskiene B. Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD. Respir Res. 2007;8:81 pubmed
    ..Smoking and disease itself may stimulate MMP-12 expression in airway compartments (IS and BAL) from COPD patients. ..
  14. Schirmer H, Basso da Silva L, Teixeira P, Moreira J, Moreira A, Simon D. Matrix metalloproteinase gene polymorphisms: lack of association with chronic obstructive pulmonary disease in a Brazilian population. Genet Mol Res. 2009;8:1028-34 pubmed publisher
    ..Haplotype analysis also did not reveal differences between COPD patients and controls. We found that MMP polymorphisms had no significant impact on the risk of developing COPD in this Brazilian sample. ..
  15. Acuff H, Sinnamon M, Fingleton B, Boone B, Levy S, Chen X, et al. Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res. 2006;66:7968-75 pubmed
    ..The use of the Hu/Mu ProtIn chip allows us to distinguish tumor- and host-derived proteases and guides the further analysis of the significance of these genes in tumor progression. ..
  16. Haq I, Chappell S, Johnson S, Lotya J, Daly L, Morgan K, et al. Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population. BMC Med Genet. 2010;11:7 pubmed publisher
    ..76; 95% CI 0.61 - 0.94). The A-A haplotype was also associated with significantly lower predicted FEV1 (42.62% versus 44.79%; p = 0.0129). This implicates haplotypes of MMP-12 as modifiers of disease severity. ..
  17. Lyu J, Joo C. Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. J Biol Chem. 2005;280:21653-60 pubmed
    ..By regulating the proliferation of corneal epithelial cells, Wnt-7a and MMP-12 appear to contribute to corneal wound healing. ..
  18. Gronski T, Martin R, Kobayashi D, Walsh B, Holman M, Huber M, et al. Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase. J Biol Chem. 1997;272:12189-94 pubmed
    ..These results suggest that HME may be required for macrophages to penetrate basement membranes and remodel injured tissue during inflammation...
  19. Molet S, Belleguic C, Lena H, Germain N, Bertrand C, Shapiro S, et al. Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease. Inflamm Res. 2005;54:31-6 pubmed
    ..Thus, we analyzed the expression and release of MMP-12 (macrophage metalloelastase) in bronchoalveolar lavage (BAL) and lung tissue from COPD patients and control subjects...
  20. Lavigne M, Thakker P, Gunn J, Wong A, Miyashiro J, Wasserman A, et al. Human bronchial epithelial cells express and secrete MMP-12. Biochem Biophys Res Commun. 2004;324:534-46 pubmed
    ..These findings indicate that the bronchial epithelium may be an important source of elastolytic activity in COPD and tissue remodeling in chronic asthma. ..
  21. Sarkar S, Nuttall R, Liu S, Edwards D, Yong V. Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12. Cancer Res. 2006;66:11771-80 pubmed
    ..These results identify a new factor, MMP-12, in regulating glioma invasiveness through interaction with tenascin-C. ..
  22. Hofmann H, Hansen G, Richter G, Taege C, Simm A, Silber R, et al. Matrix metalloproteinase-12 expression correlates with local recurrence and metastatic disease in non-small cell lung cancer patients. Clin Cancer Res. 2005;11:1086-92 pubmed
    ..MMP-12 might be not only a prognostic marker, but also a valuable therapeutic target. ..
  23. Lamblin N, Bauters C, Hermant X, Lablanche J, Helbecque N, Amouyel P. Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease. J Am Coll Cardiol. 2002;40:43-8 pubmed
    ..The MMP-3 5A allele is associated with the occurrence of CA. Our results suggest that an increased proteolysis in the arterial wall may act as a susceptibility factor for the development of CA in patients with coronary atherosclerosis. ..
  24. Edelstein C, Shapiro S, Klezovitch O, Scanu A. Macrophage metalloelastase, MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology. J Biol Chem. 1999;274:10019-23 pubmed
    In this study we found that macrophage metalloelastase, MMP-12 cleaves, in vitro, apolipoprotein(a) (apo(a)) in the Asn3518-Val3519 bond located in the linker region between kringles IV-4 and IV-5, a bond immediately upstream of the ..
  25. Nabha S, dos Santos E, Yamamoto H, Belizi A, Dong Z, Meng H, et al. Bone marrow stromal cells enhance prostate cancer cell invasion through type I collagen in an MMP-12 dependent manner. Int J Cancer. 2008;122:2482-90 pubmed publisher
    ..Our data suggest that BMS cells induce MMP-12 expression in prostate cancer cells, which results in invasive cells capable of degradation of type I collagen. ..
  26. Belaaouaj A, Shipley J, Kobayashi D, Zimonjic D, Popescu N, Silverman G, et al. Human macrophage metalloelastase. Genomic organization, chromosomal location, gene linkage, and tissue-specific expression. J Biol Chem. 1995;270:14568-75 pubmed
    Human macrophage metalloelastase (HME) is a recent addition to the matrix metalloproteinase (MMP) family that was initially found to be expressed in alveolar macrophages of cigarette smokers...
  27. Li Z, Bassett W, Askim J, Suslick K. Differentiation among peroxide explosives with an optoelectronic nose. Chem Commun (Camb). 2015;51:15312-5 pubmed publisher
    Forensic identification of batches of homemade explosives (HME) poses a difficult analytical challenge...
  28. Agrawal A, Dudhedia M, Zimny E. Hot Melt Extrusion: Development of an Amorphous Solid Dispersion for an Insoluble Drug from Mini-scale to Clinical Scale. AAPS PharmSciTech. 2016;17:133-47 pubmed publisher
    ..of the study was to develop an amorphous solid dispersion (ASD) for an insoluble compound X by hot melt extrusion (HME) process...
  29. Meguro K, Nakagomi D, Suzuki K, Hosokawa J, Fukuta T, Yokota M, et al. SOCS3 Expressed in M2 Macrophages Attenuates Contact Hypersensitivity by Suppressing MMP-12 Production. J Invest Dermatol. 2016;136:649-57 pubmed publisher
    ..Taken together, these results suggest that SOCS3 expressed in M2 macrophages is involved in the attenuation and/or resolution of CHS, presumably by suppressing MMP-12 production. ..
  30. Malaquias L, Sá Barreto L, Freire D, Silva I, Karan K, Dürig T, et al. Taste masking and rheology improvement of drug complexed with beta-cyclodextrin and hydroxypropyl-β-cyclodextrin by hot-melt extrusion. Carbohydr Polym. 2018;185:19-26 pubmed publisher
    ..For this, hot-melt extrusion (HME) was used to obtain extrudates composed of FLU, hydroxypropylcellulose, and one of two different cyclodextrins (β..
  31. Fujii M, Hodges A, Russell R, Roensch K, Beynnon B, Ahern T, et al. Post-Discharge Opioid Prescribing and Use after Common Surgical Procedure. J Am Coll Surg. 2018;: pubmed publisher
    ..Primary outcomes were the quantity of opioid prescribed and used in morphine milligram equivalents (MME), and the proportion of patients receiving instructions on disposal and nonopioid strategies...
  32. Haq I, Lowrey G, Kalsheker N, Johnson S. Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD. Thorax. 2011;66:970-6 pubmed publisher
    ..These findings further implicate MMP-12 and this SNP in COPD. ..
  33. Murphy D, Lebin J, Severtson S, Olsen H, Dasgupta N, Dart R. Comparative Rates of Mortality and Serious Adverse Effects Among Commonly Prescribed Opioid Analgesics. Drug Saf. 2018;: pubmed publisher
    ..were adjusted for availability through outpatient dispensing data and regressed on morphine milligram equivalents (MME). There were 19,480 cases of SAE during the 7-year study period...
  34. Scoutaris N, Ross S, Douroumis D. 3D Printed "Starmix" Drug Loaded Dosage Forms for Paediatric Applications. Pharm Res. 2018;35:34 pubmed publisher
    ..Hot melt extrusion processing (HME) was coupled with FDM to prepare extruded filaments of indomethacin (IND), hypromellose acetate succinate (HPMCAS) ..
  35. Yu P, Huang Y, Han Y, Lin L, Sun W, Rabson A, et al. TNF?-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting CXCR2+ neutrophils. Oncogene. 2017;36:482-490 pubmed publisher
    ..and tumor cells resulted in markedly elevated metastasis-related genes by tumor cells, including CXCR4, CXCR7, MMP12, MMP13, IL-6 and TGF?...
  36. Su L, Zhou W, Asomaning K, Lin X, Wain J, Lynch T, et al. Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer. Carcinogenesis. 2006;27:1024-9 pubmed
    ..62-8.20) when compared with the most common 1G-5A-82A-1082A haplotype. In conclusion, the combined MMP genotypes and associated haplotypes may be associated with higher risk of lung cancer, particularly among never smokers and men. ..
  37. Liu Y, Thompson M, O Donnell K. Impact of non-binder ingredients and molecular weight of polymer binders on heat assisted twin screw dry granulation. Int J Pharm. 2017;536:336-344 pubmed publisher
    Two grades of commercial AFFINISOL™ HPMC HME were used as polymer binders to explore the influence of polymer viscosity and concentration on a novel heat assisted dry granulation process with a twin screw extruder...
  38. Nichols D, Nadpara P, Taylor P, Brophy G. Intravenous Versus Oral Acetaminophen for Pain Control in Neurocritical Care Patients. Neurocrit Care. 2016;25:400-406 pubmed
    ..Pre- and postdose morphine milligram equivalents (MME) were also calculated...
  39. Bochmann E, Neumann D, Gryczke A, Wagner K. Micro-scale prediction method for API-solubility in polymeric matrices and process model for forming amorphous solid dispersion by hot-melt extrusion. Eur J Pharm Biopharm. 2016;107:40-8 pubmed publisher
    ..predictive micro-scale solubility and process model for amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is presented...
  40. Poobalasingam T, Yates L, Walker S, Pereira M, Gross N, Ali A, et al. Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. Dis Model Mech. 2017;10:409-423 pubmed publisher
    ..altered macrophage population, abnormal elastin deposition and elevated levels of the elastin-modifying enzyme, Mmp12, all of which are observed in emphysema...
  41. Fernando R, Cheng H, Golden B, Garrick D. Computational strategies for alternative single-step Bayesian regression models with large numbers of genotyped and non-genotyped animals. Genet Sel Evol. 2016;48:96 pubmed
    ..We present computational strategies to avoid storing large, dense blocks of the MME that involve imputed genotypes...
  42. LaFountaine J, Prasad L, Brough C, Miller D, McGinity J, Williams R. Thermal Processing of PVP- and HPMC-Based Amorphous Solid Dispersions. AAPS PharmSciTech. 2016;17:120-32 pubmed publisher
    ..and grades of polymers that can be utilized in common thermal processing technologies, such as hot-melt extrusion (HME), are often limited by thermal or rheological factors...
  43. Shin A, Cai Q, Shu X, Gao Y, Zheng W. Genetic polymorphisms in the matrix metalloproteinase 12 gene (MMP12) and breast cancer risk and survival: the Shanghai Breast Cancer Study. Breast Cancer Res. 2005;7:R506-12 pubmed
    Matrix metalloproteinase 12 (MMP12) is a proteolytic enzyme responsible for cleavage of plasminogen to angiotensin, which has an angiostatic effect...
  44. Chikeka I, Matute A, Dumler J, Woods C, Mayorga O, Reller M. Use of Peptide-Based Enzyme-Linked Immunosorbent Assay followed by Immunofluorescence Assay To Document Ehrlichia chaffeensis as a Cause of Febrile Illness in Nicaragua. J Clin Microbiol. 2016;54:1581-1585 pubmed publisher
    Ehrlichia chaffeensis, the etiologic agent of human monocytic ehrlichiosis (HME), has been extensively studied as a cause of acute febrile illness and an emerging tick-borne zoonosis in the United States...
  45. Pawar J, Narkhede R, Amin P, Tawde V. Design and Evaluation of Topical Diclofenac Sodium Gel Using Hot Melt Extrusion Technology as a Continuous Manufacturing Process with Kolliphor® P407. AAPS PharmSciTech. 2017;18:2303-2315 pubmed publisher
    ..and evaluate a Kolliphor® P407-based transdermal gel formulation of diclofenac sodium by hot melt extrusion (HME) technology; central composite design was used to optimize the formulation process...
  46. Xie S, Issa R, Sukkar M, Oltmanns U, Bhavsar P, Papi A, et al. Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells. Respir Res. 2005;6:148 pubmed
    ..Bronchial smooth muscle cells may be an important source of elastolytic activity, thereby participating in remodeling in airway diseases such as COPD and chronic asthma. ..
  47. Beaudin S, Welsh J. 1,25-Dihydroxyvitamin D Regulation of Glutamine Synthetase and Glutamine Metabolism in Human Mammary Epithelial Cells. Endocrinology. 2017;158:4174-4188 pubmed publisher
    ..Effects of 1,25D on GLUL/GS expression and glutamine oxidation were retained in human mammary epithelial (HME) cells that express SV-40 (HME-LT cells) but not in those that express SV-40 and oncogenic H-Ras (HME-PR cells)...
  48. Ockene J, Hayes R, Churchill L, Crawford S, Jolicoeur D, Murray D, et al. Teaching Medical Students to Help Patients Quit Smoking: Outcomes of a 10-School Randomized Controlled Trial. J Gen Intern Med. 2016;31:172-81 pubmed publisher
    ..S. medical schools that were randomized to receive either multi-modal tobacco treatment education (MME) or traditional tobacco treatment education (TE)...
  49. Mukhopadhyay S, Sypek J, Tavendale R, Gartner U, Winter J, Li W, et al. Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults. J Allergy Clin Immunol. 2010;126:70-6.e16 pubmed publisher
    ..The common serine variant at codon 357 of the MMP12 gene (rs652438) is associated with clinical manifestations consistent with more aggressive matrix degradation in ..
  50. Tiwari R, Polk A, Patil H, Ye X, Pimparade M, Repka M. Rat Palatability Study for Taste Assessment of Caffeine Citrate Formulation Prepared via Hot-Melt Extrusion Technology. AAPS PharmSciTech. 2017;18:341-348 pubmed publisher
    ..Hot-melt extrusion (HME) technology is used successfully for taste masking of bitter APIs and overcomes some of the limitations of the ..
  51. Supasorn O, Sringkarin N, Srimanote P, Angkasekwinai P. Matrix metalloproteinases contribute to the regulation of chemokine expression and pulmonary inflammation in Cryptococcus infection. Clin Exp Immunol. 2016;183:431-40 pubmed publisher
    ..Among MMP family members, we found significant increases of MMP-3 and MMP-12 mRNA levels and MMP12 zymographic activities in response to C. neoformans but not C. gattii infection...
  52. Lee S, Kim M, Kang H, Yoo S, Choi Y, Lee W, et al. Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population. Respiration. 2010;80:133-8 pubmed publisher
    ..69; 95% CI = 0.45-0.98; p = 0.04). These findings suggest that the MMP-9 -1562C-->T polymorphism could be used as a marker for determining the genetic susceptibility to COPD in a Korean population. ..
  53. Lang R, Kocourek A, Braun M, Tschesche H, Huber R, Bode W, et al. Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure. J Mol Biol. 2001;312:731-42 pubmed
    ..The MMP-12 structure is an excellent template for the structure-based design of specific inhibitors for emphysema therapy and for the construction of mutants to clarify the role of this MMP. ..
  54. D Ambrosi R, Ragone V, Caldarini C, Serra N, Usuelli F, Facchini R. The impact of hereditary multiple exostoses on quality of life, satisfaction, global health status, and pain. Arch Orthop Trauma Surg. 2017;137:209-215 pubmed publisher
    ..life (QOL), global health status, pain, and level of satisfaction in patients with hereditary multiple exostoses (HME), and to correlate the association between the severity of diseases and age, sex, number of surgical procedures, ..
  55. Bernelot Moens S, Mooij H, Hassing H, Kruit J, Witjes J, van de Sande M, et al. Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume. PLoS ONE. 2014;9:e115662 pubmed publisher
    ..Loss of function mutations (LOF) in EXT1 and EXT2 result in hereditary exostoses (HME)...
  56. Eriksson P, Jormsjö Pettersson S, Brady A, Deguchi H, Hamsten A, Powell J. Genotype-phenotype relationships in an investigation of the role of proteases in abdominal aortic aneurysm expansion. Br J Surg. 2005;92:1372-6 pubmed
    ..The plasminogen system may have a small but clinically significant role in AAA development. Much larger studies would be needed to evaluate genes of smaller effect. ..
  57. Mahdessian H, Perisic Matic L, Lengquist M, Gertow K, Sennblad B, Baldassarre D, et al. Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke. J Intern Med. 2017;282:429-444 pubmed publisher
    ..evidence from a genome-wide association study (GWAS) suggested that single nucleotide polymorphisms (SNP) near the MMP12 gene at chromosome 11q22.3 were associated with large-vessel ischaemic stroke...
  58. Vazquez Ortiz G, Pina Sanchez P, Vazquez K, Duenas A, Taja L, Mendoza P, et al. Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer. BMC Cancer. 2005;5:68 pubmed
    ..gave consistent results with the cDNA array findings for all three genes selected for study (CTSF, MMP11 and MMP12). In situ hybridization of all three genes confirmed overexpression in all the HSIL and CC...
  59. Markiewicz L, Pytel D, Mucha B, Szymanek K, Szaflik J, Szaflik J, et al. Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1β as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients. Biomed Res Int. 2015;2015:812503 pubmed publisher
    ..impact of particular polymorphic changes in the promoter regions of the -1607 1G/2G MMP1, -1562 C/T MMP9, -82 A/G MMP12, -511 C/T IL-1β, and 372 T/C TIMP1 genes on their expression level in POAG patients...
  60. Powell J. Genes predisposing to rapid aneurysm growth. Ann N Y Acad Sci. 2006;1085:236-41 pubmed
    ..There was no evidence that any specific MMP polymorphism had a clinically significant effect on aneurysm growth. However the plasminogen system (via PAI-1) appears to have a small, but clinically significant, role in aneurysm growth. ..
  61. Dabert Gay A, Czarny B, Devel L, Beau F, Lajeunesse E, Bregant S, et al. Molecular determinants of matrix metalloproteinase-12 covalent modification by a photoaffinity probe: insights into activity-based probe development and conformational variability of matrix metalloproteinases. J Biol Chem. 2008;283:31058-67 pubmed publisher
    ..Lys(241) is not conserved in MMPs, thus differences in cross-linking yields observed with this probe between MMP members may be linked to the residue variability observed at position 241 in this family. ..
  62. Nenan S, Boichot E, Planquois J, Berna P, Hitier S, Bénard T, et al. Effects of depletion of neutrophils or macrophages on the inflammatory response induced by metalloelastase (MMP-12) in mice airways. Eur J Pharmacol. 2008;579:374-81 pubmed
    ..These results indicate that resident alveolar macrophages and recruited neutrophils do not play a role in the delayed macrophage recruitment induced by rhMMP-12. ..
  63. Kwon S, Weiden M, Echevarría G, Comfort A, Naveed B, Prezant D, et al. Early elevation of serum MMP-3 and MMP-12 predicts protection from World Trade Center-lung injury in New York City Firefighters: a nested case-control study. PLoS ONE. 2013;8:e76099 pubmed publisher
    ..Elevated serum levels of MMP-3 and MMP-12 reduce the risk of developing WTC-LI. At any level of MMP-3 or 12, increased time to blood draw is associated with a diminished protective effect. ..
  64. VAN Nguyen S, Skarstedt M, Lofgren S, Zar N, Andersson R, Lindh M, et al. Gene polymorphism of matrix metalloproteinase-12 and -13 and association with colorectal cancer in Swedish patients. Anticancer Res. 2013;33:3247-50 pubmed
    ..For MMP12 and MMP13, a functional single nucleotide polymorphism (SNP) has been detected -82A ?G (rs2276109) and -77A ?G (..
  65. Belaaouaj A, Li A, Wun T, Welgus H, Shapiro S. Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation. J Biol Chem. 2000;275:27123-8 pubmed
    ..Co-localization of MMPs, TF, and TFPI in atherosclerotic tissues suggests that release of MMPs from inflammatory cell leukocytes may effect TF-mediated coagulation. ..
  66. Cao W, Wei W, Zhan Z, Xie D, Xie Y, Xiao Q. Role of miR-647 in human gastric cancer suppression. Oncol Rep. 2017;37:1401-1411 pubmed publisher
    ..the expression levels of genes associated with proliferation and metastasis in tumors, including ANK2, FAK, MMP2, MMP12, CD44 and SNAIL1...
  67. Kim J, Tomalin L, Lee J, Fitz L, Berstein G, Correa Da Rosa J, et al. Reduction of Inflammatory and Cardiovascular Proteins in the Blood of Patients with Psoriasis: Differential Responses between Tofacitinib and Etanercept after 4 Weeks of Treatment. J Invest Dermatol. 2018;138:273-281 pubmed publisher
    ..Our data suggest that a short-term systemic psoriasis treatment can cause reductions in circulating inflammatory and other proteins associated with cardiovascular risks. ..
  68. Wallace A, Sandford A, English J, Burkett K, Li H, Finley R, et al. Matrix metalloproteinase expression by human alveolar macrophages in relation to emphysema. COPD. 2008;5:13-23 pubmed publisher
    ..Furthermore, these data provide evidence to support the concept that multiple proteinases, causing both elastin and collagen degradation, are important in the pathogenesis of pulmonary emphysema. ..
  69. Callahan B, Patel J, Fawcett T, Blanck G. Cytoskeleton and ECM tumor mutant peptides: Increased protease sensitivities and potential consequences for the HLA class I mutant epitope reservoir. Int J Cancer. 2017;: pubmed publisher
    ..with AA substitutions overwhelmingly reflect increased sensitivity to proteases implicated in melanoma development (MME, CTSS, MMP2, CTSD, CTSL) in comparison to the wild-type peptide sequences...
  70. Wert S, Yoshida M, Levine A, Ikegami M, Jones T, Ross G, et al. Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc Natl Acad Sci U S A. 2000;97:5972-7 pubmed
    ..with increased activity of the matrix metalloproteinases, MMP2 and MMP9, and immunostaining for MMP9 and MMP12 in alveolar macrophages...
  71. Gately N, Kennedy J. The Development of a Melt-Extruded Shellac Carrier for the Targeted Delivery of Probiotics to the Colon. Pharmaceutics. 2017;9: pubmed publisher
    Hot melt extrusion (HME) is considered an efficient technique in developing solid molecular dispersions, and has been demonstrated to provide sustained, modified and targeted drug delivery resulting in improved bioavailability...
  72. Terp G, Christensen I, Jørgensen F. Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes. J Biomol Struct Dyn. 2000;17:933-46 pubmed
    ..general approach to the homology modeling of matrix metalloproteinases, exemplified by the modeling of MMP2, MMP9, MMP12 and MMP14 is described...
  73. Agapova O, Ricard C, Salvador Silva M, Hernandez M. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes. Glia. 2001;33:205-16 pubmed
    ..Cultured astrocytes constitutively expressed MMP2, MT1-MMP, TIMP1, and TIMP2, whereas MMP3, MMP7, MMP9, and MMP12 were not detectable in tissues or in cultured astrocytes...
  74. Wu Y, Li J, Wu J, Morgan P, Xu X, Rancati F, et al. Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD). Bioorg Med Chem Lett. 2012;22:138-43 pubmed publisher
    ..Compound 26 (MMP118), which exhibits excellent oral efficacy in the MMP-12 induced ear-swelling inflammation and lung inflammation mouse models, had been successfully advanced into Development Track status. ..
  75. Kamboh M, Demirci F, Wang X, Minster R, Carrasquillo M, Pankratz V, et al. Genome-wide association study of Alzheimer's disease. Transl Psychiatry. 2012;2:e117 pubmed publisher
    ..43. This is a potential candidate gene for AD as this is expressed in the brain and is involved in lipid metabolism. These findings need to be confirmed in additional samples. ..
  76. Ou R, Huang J, Shen H, Liu Z, Zhu Y, Zhong Q, et al. Transcriptome analysis of CD34+ cells from myelodysplastic syndrome patients. Leuk Res. 2017;62:40-50 pubmed publisher
    ..44 genes, such as MME and RAG1, and eight related pathways were identified to be commonly changed, indicating their conserved roles in ..
  77. Cohen M, Ribaux P, Epiney M, Irion O. Expression of metalloproteinases 1, 2, 7, 9, and 12 in human cytotrophoblastic cells from normal and preeclamptic placentas. Neuro Endocrinol Lett. 2012;33:406-11 pubmed
    ..In parallel, expression of MMPs, except for MMP-2, tends to be decreased in PE CTB compared to control CTB. At the exception of MMP-2, this study confirms the importance of MMPs in development of PE. ..
  78. Fajardo M, Liu C, Ilalov K, Egol K. Matrix metalloproteinases that associate with and cleave bone morphogenetic protein-2 in vitro are elevated in hypertrophic fracture nonunion tissue. J Orthop Trauma. 2010;24:557-63 pubmed publisher
    ..Both were found to directly inactivate bone morphogenetic protein-2 in vitro, the best established growth factor in bone formation and repair. ..
  79. Woodruff P, Koth L, Yang Y, Rodriguez M, Favoreto S, Dolganov G, et al. A distinctive alveolar macrophage activation state induced by cigarette smoking. Am J Respir Crit Care Med. 2005;172:1383-92 pubmed
    ..These studies identify aspects of mouse models that are directly relevant to human smokers and also reveal novel potential mediators of smoking-related diseases. ..
  80. Li S, Yu T, Tian Y, Lagan C, Jones D, Andrews G. Mechanochemical Synthesis of Pharmaceutical Cocrystal Suspensions via Hot Melt Extrusion: Enhancing Cocrystal Yield. Mol Pharm. 2017;: pubmed publisher
    ..of ibuprofen/isonicotinamide cocrystal suspensions within a matrix carrier via a single-step hot-melt extrusion (HME) process...
  81. Dandachi N, Kelly N, Wood J, Burton C, Radder J, Leme A, et al. Macrophage Elastase Induces TRAIL-mediated Tumor Cell Death through Its Carboxy-Terminal Domain. Am J Respir Crit Care Med. 2017;196:353-363 pubmed publisher
    ..Recent studies have revealed novel nonproteolytic functions of MMP12, including antimicrobial activity through a peptide within its C-terminal domain (CTD)...
  82. Korytina G, Akhmadishina L, Ianbaeva D, Viktorova T. [Polymorphism in promoter regions of matrix metalloproteinases (MMP1, MMP9, and MMP12) in chronic obstructive pulmonary disease patients]. Genetika. 2008;44:242-9 pubmed
    ..genotype and allele frequencies of polymorphisms G(-1607)GG of MMPI gene, C(-1562)T of MMP9 gene and A(-82)G of MMP12 gene do not significantly differ in the samples of chronic obstructive pulmonary disease (COPD) patients (N = 318) ..
  83. Heinemeier K, Lorentzen M, Jensen J, Schjerling P, Seynnes O, Narici M, et al. Local trauma in human patellar tendon leads to widespread changes in the tendon gene expression. J Appl Physiol (1985). 2016;120:1000-10 pubmed publisher
    ..connective tissue growth factor, scleraxis, decorin, fibromodulin, tenascin-C, tenomodulin, VEGFa, CD68, IL-6, MMP12, and MMP13. In conclusion, a moderate trauma to a healthy human tendon (e.g...
  84. Ran C, Fourier C, Michalska J, Steinberg A, Sjöstrand C, Waldenlind E, et al. Screening of genetic variants in ADCYAP1R1, MME and 14q21 in a Swedish cluster headache cohort. J Headache Pain. 2017;18:88 pubmed publisher
    ..1 receptor type 1), rs1006417, an intergenic variant on chromosome 14q21 and one rare mutation, rs147564881, in MME (membrane metalloendopeptidase)...
  85. Kovacs H, Agback T, Isaksson J. Probing water-protein contacts in a MMP-12/CGS27023A complex by nuclear magnetic resonance spectroscopy. J Biomol NMR. 2012;53:85-92 pubmed publisher
    ..Structural analysis of an ensemble of six crystal structures ruled out any exchange-relayed contributions for the amide-water interactions of interest. ..
  86. Ong H, Pinal R. Drug solubilization by means of a surface-modified edible biopolymer enabled by hot melt extrusion. J Pharm Sci. 2017;: pubmed publisher
    ..The APIs remained predominantly crystalline after HME processing. However, APIs with weak crystal structure (IBU and LOR) underwent measurable crystallinity loss...
  87. Marchant D, Bellac C, Moraes T, Wadsworth S, Dufour A, Butler G, et al. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat Med. 2014;20:493-502 pubmed publisher
    ..that activated I?B? mediates the export of IFN-? from virus-infected cells and that the inability of cells in Mmp12(-/-) but not wild-type mice to express I?B? and thus export IFN-? makes coxsackievirus type B3 infection lethal ..
  88. Bhaskaran R, Palmier M, Lauer Fields J, Fields G, Van Doren S. MMP-12 catalytic domain recognizes triple helical peptide models of collagen V with exosites and high activity. J Biol Chem. 2008;283:21779-88 pubmed publisher
    ..Partial unwinding or underwinding of the triple helix could accompany this to facilitate its hydrolysis. ..
  89. Starodubtseva N, Sobolev V, Soboleva A, Nikolaev A, Bruskin S. [Expression of genes for metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis]. Genetika. 2011;47:1254-61 pubmed
    ..Therefore, upregulation of MMP genes in the skin affected by psoriasis could result from IL-17 effects on skin cells. ..
  90. Xie J, Wang C, Huang D, Zhang Y, Xu J, Kolesnikov S, et al. TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury. J Biomech. 2013;46:890-8 pubmed publisher
    ..The different expressions of LOXs and MMPs inferred the intrinsic differences between ACL and MCL, and the intrinsic differences could help to explain their differential healing abilities. ..
  91. Margheri F, Serrati S, Lapucci A, Anastasia C, Giusti B, Pucci M, et al. Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice. Neoplasia. 2009;11:1106-15 pubmed
    We have previously shown that endothelial cell matrix metalloprotease 12 (MMP12) and pentraxin 3 (PTX3) overproduction is the main alteration accounting for reduced proneness to angiogenesis in systemic sclerosis (SSc)...
  92. Chung I, Chen L, Chung A, Chao M, Huang H, Hsueh C, et al. Matrix metalloproteinase 12 is induced by heterogeneous nuclear ribonucleoprotein K and promotes migration and invasion in nasopharyngeal carcinoma. BMC Cancer. 2014;14:348 pubmed publisher
    ..The association of hnRNP K and MMP12 expression in 82 clinically proven NPC cases was determined by immunohistochemical analysis...
  93. Van Renterghem J, Vervaet C, De Beer T. Rheological Characterization of Molten Polymer-Drug Dispersions as a Predictive Tool for Pharmaceutical Hot-Melt Extrusion Processability. Pharm Res. 2017;34:2312-2321 pubmed publisher
    ..The obtained rheological results are relevant for understanding and predicting HME processability (e.g., barrel temperature selection) and downstream processing such as injection moulding (e.g...