Gene Symbol: MMP10
Description: matrix metallopeptidase 10
Alias: SL-2, STMY2, stromelysin-2, MMP-10, matrix metalloprotease 10, matrix metalloproteinase 10 (stromelysin 2), matrix metalloproteinase-10, transin 2
Species: human
Products:     MMP10

Top Publications

  1. Sirum K, Brinckerhoff C. Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts. Biochemistry. 1989;28:8691-8 pubmed
    ..synovial cell cDNA library, and we used the cDNA to isolate the gene for human stromelysin and a related gene, stromelysin 2. We sequenced parts of the genes and found that both are contained on approximately 14 kilobase pairs of DNA...
  2. Madlener M, Werner S. cDNA cloning and expression of the gene encoding murine stromelysin-2 (MMP-10). Gene. 1997;202:75-81 pubmed
    ..Recombinant forms of murine stromelysin-1 and -2 produced in transfected COS cells were secreted and could be induced to undergo autocatalytic processing by addition of the organomercurial salt 4-aminophenylmercuric acetate (APMA). ..
  3. Nakamura H, Fujii Y, Ohuchi E, Yamamoto E, Okada Y. Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases. Eur J Biochem. 1998;253:67-75 pubmed
    ..In the present study, we have examined the intermolecular activation mechanisms of proMMP by MMP-10 (stromelysin 2)...
  4. Aung P, Oue N, Mitani Y, Nakayama H, Yoshida K, Noguchi T, et al. Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer. Oncogene. 2006;25:2546-57 pubmed
    ..As expression of MIA and MMP-10 is narrowly restricted in cancer, these two molecules may be good therapeutic targets for GC. ..
  5. Regala R, Justilien V, Walsh M, Weems C, Khoor A, Murray N, et al. Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation. PLoS ONE. 2011;6:e26439 pubmed publisher
    b>Matrix metalloproteinase 10 (MMP-10; stromelysin 2) is a member of a large family of structurally related matrix metalloproteinases, many of which have been implicated in tumor progression, invasion and metastasis...
  6. Windsor L, Grenett H, Birkedal Hansen B, Bodden M, Engler J, Birkedal Hansen H. Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters. J Biol Chem. 1993;268:17341-7 pubmed
    ..SL-2 shared with (human fibroblast) SL-1 the ability to cleave casein, to "superactivate" fibroblast type procollagenase, and to form apparently binary, SDS-resistant complexes with tissue inhibitor of metalloproteinases-1. ..
  7. Krampert M, Bloch W, Sasaki T, Bugnon P, Rülicke T, Wolf E, et al. Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin. Mol Biol Cell. 2004;15:5242-54 pubmed
    ..These results suggest that a tightly regulated expression level of stromelysin-2 is required for limited matrix degradation at the wound site, thereby controlling keratinocyte migration. ..
  8. Zhang X, Zhu S, Luo G, Zheng L, Wei J, Zhu J, et al. Expression of MMP-10 in lung cancer. Anticancer Res. 2007;27:2791-5 pubmed
    ..0030, p=0.9891). There were no statistical differences in MMP-10 mRNA levels and protein levels in relation to patient's gender, age, tumor stages, tumor size, lymph node metastasis or tumor histological type. ..
  9. Frederick L, Matthews J, Jamieson L, Justilien V, Thompson E, Radisky D, et al. Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer. Oncogene. 2008;27:4841-53 pubmed publisher
    ..Our data define a PKCiota-Par6alpha-Rac1 signaling axis that drives anchorage-independent growth and invasion of NSCLC cells through induction of MMP-10 expression. ..

More Information

Publications138 found, 100 shown here

  1. Ishikawa F, Miyoshi H, Nose K, Shibanuma M. Transcriptional induction of MMP-10 by TGF-beta, mediated by activation of MEF2A and downregulation of class IIa HDACs. Oncogene. 2010;29:909-19 pubmed publisher
  2. Liu H, Qin Y, Bi J, Guo A, Fu L, Guan X. Overexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinoma. Dis Esophagus. 2012;25:656-63 pubmed publisher
    Matrix metallopeptidase 10 (MMP10) is frequently expressed and correlates closely with metastasis and poor prognosis in various human cancers...
  3. Batra J, Robinson J, Soares A, Fields A, Radisky D, Radisky E. Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure. J Biol Chem. 2012;287:15935-46 pubmed publisher
    b>Matrix metalloproteinase 10 (MMP-10, stromelysin-2) is a secreted metalloproteinase with functions in skeletal development, wound healing, and vascular remodeling; its overexpression is also implicated in lung tumorigenesis and tumor ..
  4. Barksby H, Milner J, Patterson A, Peake N, Hui W, Robson T, et al. Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis. Arthritis Rheum. 2006;54:3244-53 pubmed
    We have previously reported the up-regulation of matrix metalloproteinase 10 (MMP-10) following treatment with the procatabolic stimulus of interleukin-1 (IL-1) and oncostatin M (OSM) in chondrocytes...
  5. Yen C, Chen C, Chang C, Tseng H, Liu S, Chuang L, et al. Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers. Biomarkers. 2009;14:244-9 pubmed publisher
    The aim of this study was to investigate the mRNA performance of matrix metalloproteinases (MMP) 1, MMP10 and MMP12 as oral cancer markers...
  6. Kadeh H, Saravani S, Heydari F, Keikha M, Rigi V. Expression of Matrix Metalloproteinase-10 at Invasive Front of Squamous Cell Carcinoma and Verrucous Carcinoma in the Oral Cavity. Asian Pac J Cancer Prev. 2015;16:6609-13 pubmed
  7. Feigenson M, Shull L, Taylor E, Camilleri E, Riester S, Van Wijnen A, et al. Histone Deacetylase 3 Deletion in Mesenchymal Progenitor Cells Hinders Long Bone Development. J Bone Miner Res. 2017;32:2453-2465 pubmed publisher
    ..Elevated expression of Mmp3 and Mmp10 transcripts was also observed...
  8. Liu F, Huang J, Liu Z. Vincristine Impairs Microtubules and Causes Neurotoxicity in Cerebral Organoids. Neuroscience. 2018;: pubmed publisher
    ..Vincristine treatment also impaired the microtubule-associated protein tubulin, and fibronectin, and downregulated MMP10 activity...
  9. Martinez de Lizarrondo S, Roncal C, Calvayrac O, Rodriguez C, Varo N, Purroy A, et al. Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2012;32:1477-87 pubmed publisher
    ..Thrombin/CD40L elicited a strong synergistic effect on endothelial MMP-10 expression and microparticles containing MMP-10 in vitro and in vivo, which may represent a new link between inflammation/thrombosis with prognostic implications. ..
  10. He S, Liu M, Zhang W, Xu N, Zhu H. Over expression of p21-activated kinase 7 associates with lymph node metastasis in esophageal squamous cell cancers. Cancer Biomark. 2016;16:203-9 pubmed publisher
    ..5 folds compared with EC9706 cells. PAK7 could enhance the protein levels of Vimentin and MMP10, but reduce E-cadherin, TIMP1 and TIMP2...
  11. Wu T, Ding H, Han J, Arriens C, Wei C, Han W, et al. Antibody-Array-Based Proteomic Screening of Serum Markers in Systemic Lupus Erythematosus: A Discovery Study. J Proteome Res. 2016;15:2102-14 pubmed publisher SLE patients who were quiescent, other molecules such as OPN, sTNFRI, sTNFRII, IGFBP2, SIGLEC5, FAS, and MMP10 exhibited the capacity to distinguish SLE from healthy controls with ROC AUC exceeding 90%, all with p < 0...
  12. Xu M, Zhang F, Wang A, Wang C, Cao Y, Zhang M, et al. Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Promotes Hepatic Stellate Cells Migration via Canonical NF-?B/MMP9 Pathway. PLoS ONE. 2016;11:e0167658 pubmed publisher
    ..assay; cell viability was evaluated by Cell Counting Kit-8; the expression of MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 gene was identified by quantitative real-time polymerase chain reaction and western blotting; ..
  13. Munasinghage Silva L, Kryza T, Stoll T, Hoogland C, Dong Y, Stephens C, et al. Integration of two in-depth quantitative proteomics approaches determines the kallikrein-related peptidase 7 (KLK7) degradome in ovarian cancer cell secretome. Mol Cell Proteomics. 2019;: pubmed publisher
    ..Biochemical validation supports a role for KLK7 in directly activating pro-MMP10, hydrolysis of IGFBP6 and cleavage of thrombospondin 1 with generation of a potentially bioactive N-terminal ..
  14. Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Fischer S, Rodriguez V, et al. GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells. Endocrinology. 2016;157:2416-31 pubmed publisher
    ..junction formation (Tjp1, Cldn12, Vcl, Tnc, Csk) and extracellular matrix reorganization (Lamc1, Col4a1, Col4a5, Mmp10, Mmp23, Timp2)...
  15. Zhang W, Cui Q, Qu W, Ding X, Jiang D, Liu H. TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma. Oncol Rep. 2018;40:206-216 pubmed publisher
    ..cohesion N‑acetyltransferase 2 (ESCO2), G protein‑coupled receptor 115 (GPR115), matrix metalloproteinases 10 (MMP10), OVO homologue‑like 1 (OVOL1) and secretoglobin family 1A member 1 (SCGB1A1), were candidate signature genes ..
  16. Li Y, Li J, Luo M, Zhou C, Shi X, Yang W, et al. Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma. Cancer Lett. 2018;430:57-66 pubmed publisher
    ..NMR could directly bind to chromatin regulator BPTF, and potentially promote MMP3 and MMP10 expression by ERK1/2 pathway through recruiting BPTF to chromatin...
  17. Gomez Rodriguez V, Orbe J, Martinez Aguilar E, Rodriguez J, Fernández Alonso L, Serneels J, et al. Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia. FASEB J. 2015;29:960-72 pubmed publisher
    ..muscle repair after ischemia using a model of femoral artery excision in wild-type (WT) and MMP-10 deficient (Mmp10(-/-)) mice...
  18. Zubakov D, Kokmeijer I, Ralf A, Rajagopalan N, Calandro L, Wootton S, et al. Towards simultaneous individual and tissue identification: A proof-of-principle study on parallel sequencing of STRs, amelogenin, and mRNAs with the Ion Torrent PGM. Forensic Sci Int Genet. 2015;17:122-128 pubmed publisher
    ..12 mRNA markers previously established for forensic tissue identification (ALAS2 and SPTB for peripheral blood, MMP10 and MMP11 for menstrual blood, HTN3 and STATH for saliva, PRM1 and TGM4 for semen, CYP2B7P1 and MUC4 for vaginal ..
  19. Seoane S, Montero J, Ocaña A, Pandiella A. Breast cancer dissemination promoted by a neuregulin-collagenase 3 signalling node. Oncogene. 2016;35:2756-65 pubmed publisher
    ..Genomic, biochemical and functional studies identified matrix metalloproteinases, particularly stromelysin 2 and collagenase 3, as key mediators of the NRG-induced dissemination properties of breast cancer cells...
  20. Gharib S, Loth D, Soler Artigas M, Birkland T, Wilk J, Wain L, et al. Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet. 2015;24:6836-48 pubmed publisher
    ..Network analysis of the ECM module implicated a candidate gene, matrix metalloproteinase 10 (MMP10), as a putative disease target...
  21. Hino M, Kamo M, Saito D, Kyakumoto S, Shibata T, Mizuki H, et al. Transforming growth factor-β1 induces invasion ability of HSC-4 human oral squamous cell carcinoma cells through the Slug/Wnt-5b/MMP-10 signalling axis. J Biochem. 2016;159:631-40 pubmed publisher
    ..Overall, these results suggest that TGF-β1 stimulates HSC-4 cell invasion through the Slug/Wnt-5b/MMP-10 signalling axis. ..
  22. Mariya T, Hirohashi Y, Torigoe T, Tabuchi Y, Asano T, Saijo H, et al. Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer. Oncotarget. 2016;7:26806-22 pubmed publisher
    ..In this study, we identified matrix metalloproteinase-10 (MMP10) is expressed in CSCs/CICs of EOC...
  23. Yang X, Zhang W, Cheng S, Yang R. High expression of lncRNA GACAT3 inhibits invasion and metastasis of non-small cell lung cancer to enhance the effect of radiotherapy. Eur Rev Med Pharmacol Sci. 2018;22:1315-1322 pubmed publisher of GACAT3 by bioinformatics analysis and our experiments, may be involved in the GACAT3-induced upregulation of MMP10. LncRNA GACAT3 may be a potential biomarker for the evaluation of curative effect and prognosis of lung cancer.
  24. Richardson S, Doyle P, Minogue B, Gnanalingham K, Hoyland J. Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc. Arthritis Res Ther. 2009;11:R126 pubmed publisher
    ..Importantly, this study suggests differences in the pathways involved in matrix degradation between painful and pain-free IVD degeneration. ..
  25. Huang X, Zhu H, Gao Z, Li J, Zhuang J, Dong Y, et al. Wnt7a activates canonical Wnt signaling, promotes bladder cancer cell invasion, and is suppressed by miR-370-3p. J Biol Chem. 2018;293:6693-6706 pubmed publisher
    ..Wnt7a ablation suppressed matrix metalloproteinase 10 (MMP10) expression, and Wnt7a overexpression increased MMP10 promoter activity through two TCF/..
  26. Ruan G, Xu J, Wang K, Zheng S, Wu J, Ren J, et al. Associations between serum S100A8/S100A9 and knee symptoms, joint structures and cartilage enzymes in patients with knee osteoarthritis. Osteoarthritis Cartilage. 2019;27:99-105 pubmed publisher
    ..assay (ELISA) was used to measure the serum levels of S100A8/S100A9, matrix metalloproteinase (MMP)-3, MMP10 and MMP13. In multivariable analyses, serum S100A8/S100A9 were positively associated with total WOMAC score (β: 0...
  27. di Martino E, Kelly G, Roulson J, Knowles M. Alteration of cell-cell and cell-matrix adhesion in urothelial cells: an oncogenic mechanism for mutant FGFR3. Mol Cancer Res. 2015;13:138-48 pubmed publisher
    ..of endogenous mutant FGFR3 in bladder cancer cells induced converse changes in transcript levels of CDH16, PLAU, MMP10, EPCAM, TNC, and HAS3, confirming them as downstream gene targets of mutant FGFR3...
  28. Brzóska K, Męczyńska Wielgosz S, Stępkowski T, Kruszewski M. Adaptation of HepG2 cells to silver nanoparticles-induced stress is based on the pro-proliferative and anti-apoptotic changes in gene expression. Mutagenesis. 2015;30:431-9 pubmed publisher
    ..leading to up-regulation of the genes promoting proliferation and inflammatory response (EGR1, FOS, JUN, HK2, IL4, MMP10, VEGFA, WISP1, CEBPB, IL8, SELPLG), genes coding the anti-apoptotic proteins (BCL2A1, CCL2) and factors involved ..
  29. Roncal C, Martinez de Lizarrondo S, Salicio A, Chevilley A, Rodriguez J, Rosell A, et al. New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator. Cardiovasc Res. 2017;113:1219-1229 pubmed publisher
    ..Considering that MMP-10 improves stroke injury, we have examined the therapeutic and protective effect of MMP10 and tPA/MMP10 as clot-dissolving and neuroprotective agent in an experimental model of ischemic stroke and studied ..
  30. Kadeh H, Saravani S, Heydari F, Shahraki S. Differential immunohistochemical expression of matrix metalloproteinase-10 (MMP-10) in non-melanoma skin cancers of the head and neck. Pathol Res Pract. 2016;212:867-871 pubmed publisher
    ..Also, the expression of MMP-10 is associated with tumor differentiation in cutaneous HNSCC. ..
  31. Miao Y, Cui L, Chen Z, Zhang L. Gene expression profiling of DMU-212-induced apoptosis and anti-angiogenesis in vascular endothelial cells. Pharm Biol. 2016;54:660-6 pubmed publisher
    ..CYP1B1, CYP1A1, PDK4, CSNK1G1, MVK, TCEB3C, and CDKN3), enzymes (RAB23, SPHK1, CHSY3, PLAU, PLA2G4C, and MMP10), and genes involved in signal transduction (TMEM217, DUSP8, and SPRY4), chromosome organization (HIST1H2BH and ..
  32. Reyes R, Rodriguez J, Orbe J, Arnau M, Evora C, Delgado A. Combined sustained release of BMP2 and MMP10 accelerates bone formation and mineralization of calvaria critical size defect in mice. Drug Deliv. 2018;25:750-756 pubmed publisher
    The effect of dual delivery of bone morphogenetic protein-2 (BMP-2) and matrix metalloproteinase 10 (MMP10) on bone regeneration was investigated in a murine model of calvarial critical-size defect, hypothesizing that it would result in ..
  33. Khan F, Pandian V, Ramraj S, Aravindan S, Herman T, Aravindan N. Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells. BMC Genomics. 2015;16:501 pubmed publisher
    ..egfr, elk1, esr1, cfos, fosb, fra, grb10, gsk3β, il1α, jund, kras, krtap1, mcp1, megf10, mmp2, mmp3, mmp9, mmp10, mta2, myb, cmyc, nf2, nos3, p21, pp38, ptpn3, cleaved parp, pkc, sdf-1β, sema3d, sele, stat3, tlr3, tnfα, tnfr1,..
  34. Gari H, Degala G, Ray R, Lucia M, Lambert J. PRL-3 engages the focal adhesion pathway in triple-negative breast cancer cells to alter actin structure and substrate adhesion properties critical for cell migration and invasion. Cancer Lett. 2016;380:505-12 pubmed publisher
    ..Conversely, overexpression of PRL-3 promoted TNBC cell invasion by upregulating matrix metalloproteinase 10, which resulted in increased TNBC cell adherence to, and degradation of, the major basement membrane ..
  35. Fortunato S, Menon R, Lombardi S. Stromelysins in placental membranes and amniotic fluid with premature rupture of membranes. Obstet Gynecol. 1999;94:435-40 pubmed
    ..were subjected to reverse transcriptase-polymerase chain reaction using primers specific for stromelysin 1, stromelysin 2, stromelysin 3, and matrilysin...
  36. Bobadilla M, Sainz N, Abizanda G, Orbe J, Rodriguez J, Páramo J, et al. The CXCR4/SDF1 axis improves muscle regeneration through MMP-10 activity. Stem Cells Dev. 2014;23:1417-27 pubmed publisher
    ..Thus, our findings support a model in which MMP-10 activity modulates CXCR4/SDF1 signaling, which is essential for efficient skeletal muscle regeneration. ..
  37. Wehland M, Aleshcheva G, Schulz H, Saar K, Hübner N, Hemmersbach R, et al. Differential gene expression of human chondrocytes cultured under short-term altered gravity conditions during parabolic flight maneuvers. Cell Commun Signal. 2015;13:18 pubmed publisher
    ..real time PCR analyses revealed that hypergravity regulated genes connected to cartilage integrity (BMP4, MMP3, MMP10, EDN1, WNT5A, BIRC3)...
  38. Burger M, De Wet H, Collins M. Matrix metalloproteinase genes on chromosome 11q22 and risk of carpal tunnel syndrome. Rheumatol Int. 2016;36:413-9 pubmed publisher
    ..The matrix metalloproteinases (MMPs) play an important role in connective tissue remodelling. Variants within the MMP10, MMP1, MMP3 and MMP12 gene cluster on chromosome 11q22 have been associated with connective tissue injuries...
  39. Costa A, Ferreira R, Pinto Ribeiro I, Sougleri I, Oliveira M, Carreto L, et al. Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways. J Infect Dis. 2016;213:1767-76 pubmed publisher
    ..The aim of this study was to explore the mechanisms leading to upregulation of MMP10 in gastric epithelial cells induced by H. pylori Infection of gastric cells with H...
  40. Moussa C, Hebron M, Huang X, Ahn J, Rissman R, Aisen P, et al. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease. J Neuroinflammation. 2017;14:1 pubmed publisher
    ..Compared to baseline, resveratrol increased plasma MMP10 and decreased IL-12P40, IL12P70, and RANTES...
  41. Ogata T, Shibamura H, Tromp G, Sinha M, Goddard K, Sakalihasan N, et al. Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. J Vasc Surg. 2005;41:1036-42 pubmed
    ..associations between DNA sequence changes in tissue inhibitor of metalloproteinase 1 (TIMP1), TIMP3, matrix metalloproteinase 10 (MMP10) and elastin (ELN) genes, and AAA...
  42. Ehlken C, Grundel B, Michels D, Junker B, Stahl A, Schlunck G, et al. Increased expression of angiogenic and inflammatory proteins in the vitreous of patients with ischemic central retinal vein occlusion. PLoS ONE. 2015;10:e0126859 pubmed publisher
    ..Expression of proteins enriched in the vitreous (CCL2, IGFBP2, MMP10, HGF, TNFRSF11B (OPG)) was localized by immunohistochemistry in eyes of patients with severe ischemic CRVO ..
  43. Thakur S, Nabbi A, Klimowicz A, Riabowol K. Stromal ING1 expression induces a secretory phenotype and correlates with breast cancer patient survival. Mol Cancer. 2015;14:164 pubmed publisher
    ..increased or decreased the expression of different cytokines, ING1 also increased the levels of MMP1, MMP3 and MMP10 by 5-8 fold, and concomitantly decreased levels of the tissue inhibitors of metalloproteases TIMP2, TIMP3 and ..
  44. Burnell S, Spencer Harty S, Howarth S, Bodger O, Kynaston H, Morgan C, et al. STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells. Sci Rep. 2018;8:6252 pubmed publisher
    ..Additionally, STEAP2 downstream targets associated with driving invasion were identified as MMP3, MMP10, MMP13, FGFR4, IL1β, KiSS1 and SERPINE1 in PC3 cells and, MMP7 in LNCaP cells, with CD82 altered in both...
  45. Rohani M, McMahan R, Razumova M, Hertz A, Cieslewicz M, Pun S, et al. MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages. J Invest Dermatol. 2015;135:2377-2384 pubmed publisher
    ..We observed increased collagen deposition and skin stiffness in Mmp10(-/-) wounds, with no difference in collagen expression or reepithelialization...
  46. Saghizadeh M, Dib C, Brunken W, Ljubimov A. Normalization of wound healing and stem cell marker patterns in organ-cultured human diabetic corneas by gene therapy of limbal cells. Exp Eye Res. 2014;129:66-73 pubmed publisher
    ..Gene therapy of limbal epithelial stem cell compartment has a beneficial effect on the diabetic corneal wound healing and on diabetic and stem cell marker expression, and shows potential for alleviating symptoms of diabetic keratopathy. ..
  47. Wight T, Frevert C, Debley J, Reeves S, Parks W, Ziegler S. Interplay of extracellular matrix and leukocytes in lung inflammation. Cell Immunol. 2017;312:1-14 pubmed publisher
    ..Macrophages are present in both early and late lung inflammation. Matrix metalloproteinase 10 (MMP10) is induced in alveolar macrophages with injury and infection and modulates macrophage phenotype ..
  48. Jung J, Warter S, Rumpler Y. Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization. Ann Genet. 1990;33:21-3 pubmed
    b>Stromelysin 2 is one member of the metalloproteinase family. The mapped the gene locus of stromelysin 2 to chromosome 11q22.3-23 by in situ hybridization.
  49. Zhang G, Gomes Giacoia E, Dai Y, Lawton A, Miyake M, Furuya H, et al. Validation and clinicopathologic associations of a urine-based bladder cancer biomarker signature. Diagn Pathol. 2014;9:200 pubmed publisher
    ..of a urine-based bladder cancer associated diagnostic signature comprised of 10 targets; ANG, CA9, MMP9, MMP10, SERPINA1, APOE, SDC1, VEGFA, SERPINE1 and IL8 in bladder tumor tissues...
  50. Shimizu K, Nishiyama T, Hori Y. Gemcitabine Enhances Kras-MEK-Induced Matrix Metalloproteinase-10 Expression Via Histone Acetylation in Gemcitabine-Resistant Pancreatic Tumor-initiating Cells. Pancreas. 2017;46:268-275 pubmed publisher
    ..Our results may provide novel insights into gemcitabine-based treatment for gemcitabine-resistant pancreatic ductal adenocarcinoma. ..
  51. Hoffmann J, Marsh L, Pieper M, Stacher E, Ghanim B, Kovacs G, et al. Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients. Am J Physiol Lung Cell Mol Physiol. 2015;308:L1002-13 pubmed publisher
    ..matrix metalloproteinase (MMP) 19, and a disintegrin and metalloprotease (ADAM) 33 were higher expressed, whereas MMP10, ADAM17, TIMP1, and TIMP3 were less abundant...
  52. Suomela S, Koljonen V, Skoog T, Kukko H, Bohling T, Saarialho Kere U. Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma. Virchows Arch. 2009;455:495-503 pubmed publisher
    ..Expression of MMP-21 and MMP-28 seems to associate with the tumors of lesser malignant potential. We also confirm the previous finding on the role of MMP-10 in MCC pathogenesis. ..
  53. Kufaishi H, Alarab M, Drutz H, Lye S, Shynlova O. Static Mechanical Loading Influences the Expression of Extracellular Matrix and Cell Adhesion Proteins in Vaginal Cells Derived From Premenopausal Women With Severe Pelvic Organ Prolapse. Reprod Sci. 2016;23:978-92 pubmed publisher
    ..05); in POP-HVCs, MMP1, MMP3, and MMP10, ADAMTS8 and 13, tissue inhibitor of metalloproteinases (TIMPs) 1 to 3, ITGA2, ITGA4, ITGA6, ITGB1, contactin (..
  54. Pendas A, Santamaria I, Alvarez M, Pritchard M, Lopez Otin C. Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3. Genomics. 1996;37:266-8 pubmed
  55. Carino A, Graziosi L, D Amore C, Cipriani S, Marchianò S, Marino E, et al. The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines. Oncotarget. 2016;7:61021-61035 pubmed publisher
    ..a dual FXR and GPBAR1 ligand) increased the expression of genes associated with EMT including KDKN2A, HRAS, IGB3, MMP10 and MMP13 and downregulated the expression of CD44 and FAT1 (P<0.01 versus control cells)...
  56. Vandivort T, Birkland T, Domiciano T, Mitra S, Kavanagh T, Parks W. Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes. Int J Nanomedicine. 2017;12:1019-1031 pubmed publisher
    ..MMP-10) has roles in modulating macrophage activation and function, and hence, we used an MMP-10 null (Mmp10-/-) mouse model to assess its role in controlling lung responses to inhaled long MWCNTs...
  57. Posthumus M, Collins M, van der Merwe L, O Cuinneagain D, van Der Merwe W, Ribbans W, et al. Matrix metalloproteinase genes on chromosome 11q22 and the risk of anterior cruciate ligament (ACL) rupture. Scand J Med Sci Sports. 2012;22:523-33 pubmed publisher
    ..All participants were genotyped for the MMP10 C/T rs486055, MMP1 1G/2G rs1799750, MMP3 G/A rs679620 and MMP12 A/G rs2276109 variants...
  58. Gourraud P, Sdika M, Khankhanian P, Henry R, Beheshtian A, Matthews P, et al. A genome-wide association study of brain lesion distribution in multiple sclerosis. Brain. 2013;136:1012-24 pubmed publisher
  59. Barrio Real L, Wertheimer E, Garg R, Abba M, Kazanietz M. Characterization of a P-Rex1 gene signature in breast cancer cells. Oncotarget. 2016;7:51335-51348 pubmed publisher
    ..HRG induction of MMP10 (matrix metalloproteinase 10) was found to be highly sensitive both to P-Rex1 depletion and inhibition of Rac1 function by the ..
  60. Morgan A, Han D, Lam W, Triggs C, Fraser A, Barclay M, et al. Genetic variations in matrix metalloproteinases may be associated with increased risk of ulcerative colitis. Hum Immunol. 2011;72:1117-27 pubmed publisher
    ..Further studies are needed in other cohorts to determine the robustness of these observations in different populations. ..
  61. Kufaishi H, Alarab M, Drutz H, Lye S, Shynlova O. Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse. Reprod Sci. 2016;23:931-43 pubmed publisher
    ..05) increased transcript levels of collagen VII, multiple matrix metalloproteinases (MMP3, MMP7, MMP10, MMP12, MMP13, and MMP14), integrins (ITGA1, ITGA4, ITGA6, ITGA8, ITGB1, ITGB2, and ITGB3), and cell adhesion ..
  62. Nissinen L, Kähäri V. Collagen Turnover in Wound Repair--A Macrophage Connection. J Invest Dermatol. 2015;135:2350-2352 pubmed publisher
    ..These results emphasize the important role of macrophage-derived MMP-10 in regulating tissue remodeling and scar formation during wound healing. ..
  63. Klupp F, Neumann L, Kahlert C, Diers J, Halama N, Franz C, et al. Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients. BMC Cancer. 2016;16:494 pubmed publisher
    ..Differences in the expression pattern of MMP7, MMP10 and MMP12 in 78 serum specimens of patients with an adenocarcinoma of the colon and serum specimens of a healthy ..
  64. Shimizu Y, Furuya H, Bryant Greenwood P, Chan O, Dai Y, Thornquist M, et al. A multiplex immunoassay for the non-invasive detection of bladder cancer. J Transl Med. 2016;14:31 pubmed publisher
    ..constructed (Meso Scale Diagnostics, LLC, Rockville, MD, USA) to detect the following urinary proteins; IL8, MMP9, MMP10, ANG, APOE, SDC1, A1AT, PAI1, CA9 and VEGFA...
  65. Ujfaludi Z, Tűzesi Á, Majoros H, Rothler B, Pankotai T, Boros I. Coordinated activation of a cluster of MMP genes in response to UVB radiation. Sci Rep. 2018;8:2660 pubmed publisher
    ..3 MMP gene cluster including MMP13, MMP12, MMP3, MMP1 and MMP10. Curiously, the expression of the well-characterized UVB-inducible MMP9, which is located outside of the cluster, ..
  66. Datar I, Feng J, Qiu X, Lewandowski J, Yeung M, Ren G, et al. RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13. PLoS ONE. 2015;10:e0134494 pubmed publisher
    ..expression datasets we observe that the expression of multiple metalloproteases (MMPs) including MMP1, MMP3, MMP10 and MMP13 are negatively correlated with RKIP expression in breast cancer cell lines and clinical samples...
  67. Lv Y, Gao S, Zhang Y, Wang L, Chen X, Wang Y. miRNA and target gene expression in menstrual endometria and early pregnancy decidua. Eur J Obstet Gynecol Reprod Biol. 2016;197:27-30 pubmed publisher
    ..miR-199a-3p, miR-423, miR-22-3p, let-7i-5p, and miR-1 and the predicted target genes IGF2R, LEPR, SGK1, MMP2, MMP10, LIF, IL6, and STAT3 in menstrual endometria and early pregnancy decidua...
  68. McMahan R, Birkland T, Smigiel K, Vandivort T, Rohani M, MANICONE A, et al. Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation. J Immunol. 2016;197:899-909 pubmed publisher
    ..Stromelysin-2 (MMP10) is expressed by macrophages in numerous tissues after injury; however, little is known of its function...
  69. Murray M, Birkland T, Howe J, Rowan A, Fidock M, Parks W, et al. Macrophage migration and invasion is regulated by MMP10 expression. PLoS ONE. 2013;8:e63555 pubmed publisher
    ..identify metalloproteinase determinants of macrophage migration and led to the specific hypothesis that matrix metalloproteinase 10 (MMP10/stromelysin-2) facilitates macrophage migration...
  70. Kramerov A, Saghizadeh M, Ljubimov A. Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells. J Vis Exp. 2016;:e54058 pubmed publisher
    ..This approach may be useful not only for the selected genes but also for the other mediators of corneal epithelial wound healing and stem cell function. ..
  71. Rath N, Morton J, Julian L, Helbig L, Kadir S, McGhee E, et al. ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Mol Med. 2017;9:198-218 pubmed publisher
    ..that facilitate extracellular matrix remodeling, with greatest fold-changes for matrix metalloproteinases (MMPs) Mmp10 and Mmp13 MMP inhibition not only decreased collagen degradation and invasion, but also reduced proliferation in ..
  72. Quintero Ronderos P, Mercier E, Fukuda M, Gonzalez R, Suárez C, Patarroyo M, et al. Novel genes and mutations in patients affected by recurrent pregnancy loss. PLoS ONE. 2017;12:e0186149 pubmed publisher
    ..We consider that some of these variants (and genes) represent probable future biomarkers for recurrent pregnancy loss. ..
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    ..Thus, NO may play a role in Barrett's carcinogenesis through deregulating MMP and TIMP expression to enhance invasive potential. ..
  74. Huang B, Svensson P, Arnlov J, Sundstrom J, Lind L, Ingelsson E. Effects of cigarette smoking on cardiovascular-related protein profiles in two community-based cohort studies. Atherosclerosis. 2016;254:52-58 pubmed publisher
  75. Boyd S, Virolainen S, Pärssinen J, Skoog T, van Hogerlinden M, Latonen L, et al. MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer. Exp Dermatol. 2009;18:1044-52 pubmed publisher
    ..MMP-21 does not associate with invasion of SCC but may be involved in keratinocyte differentiation...
  76. Li J, Zhu S, Li S, Zhao Y, Xu J, Song C. TKTL1 promotes cell proliferation and metastasis in esophageal squamous cell carcinoma. Biomed Pharmacother. 2015;74:71-6 pubmed publisher
    ..of anti-metastasis genes (MTSS1, TIMP2 and CTSK) and down-regulation of pr-metastasis genes (MMP2, MMP9, MMP10 and MMP13)...
  77. Xu Y, Tang H, Zhu S, Peng H, Qi Z, Wang W. RIP3 deficiency exacerbates inflammation in dextran sodium sulfate-induced ulcerative colitis mice model. Cell Biochem Funct. 2017;35:156-163 pubmed publisher
    ..6, interleukin 22, cyclooxygenase 2, epithelial growth factor receptor ligand Epiregulin and matrix metalloproteinase 10 were siginificant decreased in RIP3-/- mice...
  78. Tiwari A, Pattnaik N, Mohanty Jaiswal A, Dixit M. Increased FSHD region gene1 expression reduces in vitro cell migration, invasion, and angiogenesis, ex vivo supported by reduced expression in tumors. Biosci Rep. 2017;37: pubmed publisher
    ..stimulating factor (G-CSF) expression with FRG1 overexpression and increased expression of matrix metalloproteinase 10 (MMP10) with FRG1 knockdown...
  79. Crowley J, Strle K, Drouin E, Pianta A, Arvikar S, Wang Q, et al. Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis. J Autoimmun. 2016;69:24-37 pubmed publisher
    ..This experience demonstrates the power of new, discovery-based methods to identify relevant autoimmune responses in chronic inflammatory forms of arthritis. ..
  80. Underbayev C, Kasar S, Ruezinsky W, Degheidy H, Schneider J, Marti G, et al. Role of mir-15a/16-1 in early B cell development in a mouse model of chronic lymphocytic leukemia. Oncotarget. 2016;7:60986-60999 pubmed publisher
    ..exogenously delivered miR-15a into the NZB derived B cell line provided valuable clues into novel targets such as Mmp10 and Mt2...
  81. Goodison S, Ogawa O, Matsui Y, Kobayashi T, Miyake M, Ohnishi S, et al. A multiplex urinary immunoassay for bladder cancer detection: analysis of a Japanese cohort. J Transl Med. 2016;14:287 pubmed
    ..The protein biomarker panel (IL8, MMP9, MMP10, ANG, APOE, SDC1, A1AT, PAI1, CA9, VEGFA) was monitored in voided urine samples collected prior to cystoscopy ..
  82. Conca W, Willmroth F. Human T lymphocytes express a member of the Matrix Metalloproteinase gene family. Arthritis Rheum. 1994;37:951-6 pubmed
    ..8-kilobase transcript in stimulated T lymphocytes. T lymphocytes are a potential source of stromelysin-2 transcripts and may have a role in the degradation of extracellular matrix constituents. ..
  83. Bord S, Horner A, Hembry R, Compston J. Stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) expression in developing human bone: potential roles in skeletal development. Bone. 1998;23:7-12 pubmed
    ..In situ zymography demonstrates that SL-2 is produced in an active form with associated degradation, whereas SL-1, in a matrix-bound proenzyme form, may act as a reservoir for later activation. ..
  84. Couillard J, Demers M, Lavoie G, St Pierre Y. The role of DNA hypomethylation in the control of stromelysin gene expression. Biochem Biophys Res Commun. 2006;342:1233-9 pubmed
    ..Finally, we found that induction of mmp-3 and mmp-10 gene expression by hypomethylation was cell-specific, suggesting that epigenetic changes may predispose cells to express stromelysin genes. ..
  85. Yang B, Huang J, Xiang T, Yin X, Luo X, Huang J, et al. Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway. J Appl Toxicol. 2014;34:105-12 pubmed publisher
    ..In conclusion, our study indicates that chrysin exerts antimetastatic activities in TNBC cells, which suggests that chrysin might be a potential therapeutic candidate for the treatment of advanced or metastatic breast cancer. ..
  86. Kadeh H, Heydari F, Saravani S, Ghodsi I. Protein Expression of Stromelysin-2 in Head and Neck Squamous Cell Carcinomas. Asian Pac J Cancer Prev. 2015;16:7843-6 pubmed
    ..05), and there was no significant difference between grades II and III (P=0.99). According to this study, the expression of ST-2 is associated with histopathological grade and tumor differentiation in HNSCCs. ..
  87. Lichtinghagen R, Helmbrecht T, Arndt B, Böker K. Expression pattern of matrix metalloproteinases in human liver. Eur J Clin Chem Clin Biochem. 1995;33:65-71 pubmed
    ..Their expression pattern is not changed fundamentally in hepatocellular carcinoma but is completely different from that of other tumour tissues such as cholangiocellular carcinoma. ..
  88. Knauper V, Murphy G, Tschesche H. Activation of human neutrophil procollagenase by stromelysin 2. Eur J Biochem. 1996;235:187-91 pubmed
    Neutrophil procollagenase (MMP-8) was efficiently activated by incubation with active stromelysin 2 (MMP-10)...
  89. Sorsa T, Salo T, Koivunen E, Tyynela J, Konttinen Y, Bergmann U, et al. Activation of type IV procollagenases by human tumor-associated trypsin-2. J Biol Chem. 1997;272:21067-74 pubmed
    ..The ability of human tumor cell-derived trypsin-2 to activate latent MMPs suggests a role for trypsin-2 in initiating the proteinase cascade that mediates tumor invasion and metastasis formation. ..
  90. Nakamura H, Fujii Y, Inoki I, Sugimoto K, Tanzawa K, Matsuki H, et al. Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites. J Biol Chem. 2000;275:38885-90 pubmed
  91. Wertz K, Seifert N, Hunziker P, Riss G, Wyss A, Lankin C, et al. Beta-carotene inhibits UVA-induced matrix metalloprotease 1 and 10 expression in keratinocytes by a singlet oxygen-dependent mechanism. Free Radic Biol Med. 2004;37:654-70 pubmed
    ..Beta-carotene did not regulate the genes encoding other RARs, RXRs, or the two beta-carotene cleavage enzymes. These results demonstrate that beta-carotene acts photoprotectively, and that this effect is mediated by (1)O(2) quenching. ..
  92. Komosinska Vassev K, Olczyk P, Winsz Szczotka K, Kuznik Trocha K, Klimek K, Olczyk K. Age- and gender-dependent changes in connective tissue remodeling: physiological differences in circulating MMP-3, MMP-10, TIMP-1 and TIMP-2 level. Gerontology. 2011;57:44-52 pubmed publisher
    ..Moreover, these findings highlight the necessity of utilizing age- and sex-matched values for analysis of MMPs and TIMPs in the pathological conditions. ..