Gene Symbol: MMP-8
Description: matrix metallopeptidase 8
Alias: CLG1, HNC, MMP-8, PMNL-CL, neutrophil collagenase, PMN leukocyte collagenase, PMNL collagenase, collagenase 2, matrix metalloproteinase 8 (neutrophil collagenase), matrix metalloproteinase-8
Species: human
Products:     MMP-8

Top Publications

  1. Lee J, Kim H, Min J, Park J, Jin S, Han S, et al. Lack of association between matrix metalloproteinase 8 promoter polymorphism and bronchiectasis in Koreans. J Korean Med Sci. 2007;22:667-71 pubmed
    ..76), colonization of microorganisms (p=0.56), or association of mycobacteria (p=0.17). From these results, we conclude that -799C/T on the promoter region of MMP-8 lacks association with development of bronchiectasis in Koreans. ..
  2. Taghavi S, Krenn K, Jaksch P, Klepetko W, Aharinejad S. Broncho-alveolar lavage matrix metalloproteases as a sensitive measure of bronchiolitis obliterans. Am J Transplant. 2005;5:1548-52 pubmed
    ..BAL MMP-8, -9 and TIMP-1 might be useful markers to detect BO in lung transplant patients. ..
  3. Decock J, Long J, Laxton R, Shu X, Hodgkinson C, Hendrickx W, et al. Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis. Cancer Res. 2007;67:10214-21 pubmed
    ..The data suggest that MMP8 gene variation may influence breast cancer prognosis and support the notion that MMP8 has an inhibitory effect on cancer metastasis. ..
  4. Decock J, Hendrickx W, Vanleeuw U, Van Belle V, Van Huffel S, Christiaens M, et al. Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis. BMC Cancer. 2008;8:77 pubmed publisher
    ..Interestingly, our results suggest that MMP8 may affect the metastatic behaviour of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. ..
  5. Kong M, Gaggar A, Li Y, Winkler M, Blalock J, Clancy J. Matrix metalloproteinase activity in pediatric acute lung injury. Int J Med Sci. 2009;6:9-17 pubmed
    ..These results identify a specific repertoire of MMP isoforms in the lung secretions of pediatric ALI patients, and demonstrate inverse changes in MMPs -8 and -9 with protracted disease. ..
  6. McQuibban G, Gong J, Wong J, Wallace J, Clark Lewis I, Overall C. Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood. 2002;100:1160-7 pubmed
    ..Specificity was shown by absence of cleavage by matrilysin (MMP-7) and the leukocytic MMPs neutrophil collagenase (MMP-8) and gelatinase B (MMP-9)...
  7. Owen C, Hu Z, Lopez Otin C, Shapiro S. Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J Immunol. 2004;172:7791-803 pubmed
    ..TIMP-resistant, active MMP-8 expressed on the surface of activated PMN is likely to be an important form of MMP-8, regulating lung inflammation and collagen turnover in vivo. ..
  8. Kader A, Liu J, Shao L, Dinney C, Lin J, Wang Y, et al. Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness. Clin Cancer Res. 2007;13:2614-20 pubmed
    ..32; 95% CI, 1.30-4.12). Our results suggest that genetic changes in MMPs are associated with the development of invasive bladder cancer. ..
  9. Vihinen P, Koskivuo I, Syrjanen K, Tervahartiala T, Sorsa T, Pyrhonen S. Serum matrix metalloproteinase-8 is associated with ulceration and vascular invasion of malignant melanoma. Melanoma Res. 2008;18:268-73 pubmed publisher
    ..Results also suggest that elevated serum MMP-8 might be related to haematogenous spreading of melanoma through vascular invasion. ..

More Information

Publications114 found, 100 shown here

  1. Thirkettle S, Decock J, Arnold H, Pennington C, Jaworski D, Edwards D. Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells. J Biol Chem. 2013;288:16282-94 pubmed publisher
    b>Matrix metalloproteinase 8 (MMP-8) is a tumor-suppressive protease that cleaves numerous substrates, including matrix proteins and chemokines...
  2. Prikk K, Maisi P, Pirila E, Sepper R, Salo T, Wahlgren J, et al. In vivo collagenase-2 (MMP-8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis. J Pathol. 2001;194:232-8 pubmed
    ..MMP-8 from multiple cellular sources, including inflamed lung epithelium, was activated to a significant extent in the BE BALF, indicating a major role for MMP-8 in the destruction of lung and bronchial tissues. ..
  3. Wang H, Parry S, Macones G, Sammel M, Ferrand P, Kuivaniemi H, et al. Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM). Hum Mol Genet. 2004;13:2659-69 pubmed
    b>Matrix metalloproteinase 8 (MMP8), an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells...
  4. Tuomainen A, Nyyssonen K, Laukkanen J, Tervahartiala T, Tuomainen T, Salonen J, et al. Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men. Arterioscler Thromb Vasc Biol. 2007;27:2722-8 pubmed
    ..03 (1.09 to 8.44). TIMP-1 concentrations alone had no predictive value. The results indicate that serum MMP-8 concentrations are elevated in prevalent or subclinical atherosclerosis and associate with the worst cardiovascular outcome. ..
  5. Palavalli L, Prickett T, Wunderlich J, Wei X, Burrell A, Porter Gill P, et al. Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. Nat Genet. 2009;41:518-20 pubmed publisher
    ..Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression. ..
  6. Li Y, Shao A, Jiang H, Dong G, Xu B, Yi J, et al. The prominent expression of plasma matrix metalloproteinase-8 in acute thoracic aortic dissection. J Surg Res. 2010;163:e99-104 pubmed publisher
    ..MMP-8 could be involved in the acute inflammatory reaction and may be a useful marker for the diagnosis of acute TAD. ..
  7. Hasty K, Pourmotabbed T, Goldberg G, Thompson J, Spinella D, Stevens R, et al. Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. J Biol Chem. 1990;265:11421-4 pubmed
    We have identified and sequenced a cDNA encoding human neutrophil collagenase from a lambda gt11 cDNA library constructed from mRNA extracted from the peripheral leukocytes of a patient with chronic granulocytic leukemia...
  8. Cole A, Chubinskaya S, Schumacher B, Huch K, Szabo G, Yao J, et al. Chondrocyte matrix metalloproteinase-8. Human articular chondrocytes express neutrophil collagenase. J Biol Chem. 1996;271:11023-6 pubmed
    This study confirms that normal human articular chondrocytes express neutrophil collagenase or matrix metalloproteinase-8 (MMP-8), a gene product previously thought to be expressed exclusively by neutrophil leukocytes...
  9. Dorweiler B, Torzewski M, Dahm M, Kirkpatrick C, Lackner K, Vahl C. Subendothelial infiltration of neutrophil granulocytes and liberation of matrix-destabilizing enzymes in an experimental model of human neo-intima. Thromb Haemost. 2008;99:373-81 pubmed publisher
    ..The concomitant release of potent matrix-degrading enzymes and the induction of EC apoptosis may have implications for plaque destabilization and cardiovascular events. ..
  10. Laxton R, Hu Y, Duchene J, Zhang F, Zhang Z, Leung K, et al. A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res. 2009;105:921-9 pubmed publisher
    ..A relationship among MMP8 gene variation, plasma VCAM-1 level, and atherosclerosis progression was also observed in a population-based, prospective study. These results indicate that MMP8 is an important player in atherosclerosis. ..
  11. Quintero P, Knolle M, Cala L, Zhuang Y, Owen C. Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice. J Immunol. 2010;184:1575-88 pubmed publisher
    ..In addition, membrane-bound MMP-8 on activated lung PMNs is likely to be the key bioactive form of the enzyme that limits lung inflammation and alveolar capillary barrier injury during ALI. ..
  12. Barber B, McNeely M, Chan K, Beaudry R, Olson J, Harris J, et al. Intraoperative brief electrical stimulation (BES) for prevention of shoulder dysfunction after oncologic neck dissection: study protocol for a randomized controlled trial. Trials. 2015;16:240 pubmed publisher
    Shoulder pain and dysfunction are common after oncologic neck dissection for head and neck cancer (HNC), due to traction, compression, and devascularization injuries to the spinal accessory nerve (SAN)...
  13. Sannigrahi M, Sharma R, Singh V, Panda N, Rattan V, Khullar M. DNA methylation regulated microRNAs in HPV-16-induced head and neck squamous cell carcinoma (HNSCC). Mol Cell Biochem. 2018;448:321-333 pubmed publisher
    ..expressed miRNAs were validated in control (n = 10), HPV-16 +ve (n = 30), and HPV -ve (n = 30) HNC, TCGA (n = 529) tissue samples, and two HPV -ve (SCC116 and Hacat) and two HPV +ve (SCC090 and SiHa) cell ..
  14. Mancini M, Caignard G, Charbonneau B, Dumaine A, Wu N, Leiva Torres G, et al. Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis. J Immunol. 2019;: pubmed publisher
    ..In summary, our work implicates c-Rel in both CNS-resident cell survival and lymphocyte responses to HSV-1 infection and as a novel cause of HSE disease susceptibility in mice. ..
  15. Sannigrahi M, Sharma R, Singh V, Panda N, Rattan V, Khullar M. Role of Host miRNA Hsa-miR-139-3p in HPV-16-Induced Carcinomas. Clin Cancer Res. 2017;23:3884-3895 pubmed publisher
    b>Purpose: Human papillomavirus 16 (HPV-16) is an important risk factor in head and neck cancer (HNC)...
  16. Cannon C, Trembley J, Kren B, Unger G, O Sullivan M, Cornax I, et al. Therapeutic Targeting of Protein Kinase CK2 Gene Expression in Feline Oral Squamous Cell Carcinoma: A Naturally Occurring Large-Animal Model of Head and Neck Cancer. Hum Gene Ther Clin Dev. 2017;28:80-86 pubmed publisher
    ..and anti-CK2 gene expression therapy has shown effectiveness in rodent models of human head and neck cancer (HNC). To date, there has been no large-animal model of cancer in which to further explore anti-CK2 therapies...
  17. An S, Zong G, Wang Z, Shi J, Du H, Hu J. Expression of inducible nitric oxide synthase in mast cells contributes to the regulation of inflammatory cytokines in irritable bowel syndrome with diarrhea. Neurogastroenterol Motil. 2016;28:1083-93 pubmed publisher
    ..Our findings provide new evidence that NO is able to regulate many cytokines in MCs that may be involved in the development of IBS. ..
  18. Deniffel D, Sauter A, Dangelmaier J, Fingerle A, Rummeny E, Pfeiffer D. Differentiating intrapulmonary metastases from different primary tumors via quantitative dual-energy CT based iodine concentration and conventional CT attenuation. Eur J Radiol. 2019;111:6-13 pubmed publisher
    ..breast (invasive-ductal adenocarcinoma; n = 17), colorectal (CRC) (adenocarcinoma; n = 27), head and neck (HNC) (squamous cell carcinoma; n = 17), kidney (RCC) (clear-cell renal cell carcinoma; n = 10), lung (..
  19. Sendi H, Mead I, Wan M, Mehrab Mohseni M, Koch K, Atala A, et al. miR-122 inhibition in a human liver organoid model leads to liver inflammation, necrosis, steatofibrosis and dysregulated insulin signaling. PLoS ONE. 2018;13:e0200847 pubmed publisher
    ..Patients with NAFLD are known to have altered levels of miR-122, therefore we suggest that miR-122 mimics could play a useful role in reversing liver steatofibrosis and insulin resistance seen in patients with NAFLD. ..
  20. Santos C, Fonseca J, Carolino E, Guerreiro A. Serum trace elements in dysphagic gastrostomy candidates before endoscopic gastrostomy for long term enteral feeding. Clin Nutr. 2016;35:718-23 pubmed publisher
    ..The patients were divided into head and neck cancer (HNC) and neurological dysphagia (ND). 146 patients (89 males), 21-95 years: HNC-56; ND-90. Low BMI in 78...
  21. Zhang X, Bao W, Fei X, Zhang Y, Zhang G, Zhou X, et al. Progesterone attenuates airway remodeling and glucocorticoid resistance in a murine model of exposing to ozone. Mol Immunol. 2018;96:69-77 pubmed publisher
    ..Progesterone plus BUD administration exerts more significant inhibition on airway remodeling with dose-independent. Additionally, progesterone may, to some extent, improve the glucocorticoid insensitivity. ..
  22. Kufaishi H, Alarab M, Drutz H, Lye S, Shynlova O. Static Mechanical Loading Influences the Expression of Extracellular Matrix and Cell Adhesion Proteins in Vaginal Cells Derived From Premenopausal Women With Severe Pelvic Organ Prolapse. Reprod Sci. 2016;23:978-92 pubmed publisher
    ..Risk factors that induce stretch may alter ECM composition and cell-ECM interaction in pelvic floor tissue leading to the abatement of pelvic organ support and subsequent POP development. ..
  23. Chang Y, Soriano M, Hahn R, Casillas R, Gordon M, Laskin J, et al. Expression of cytokines and chemokines in mouse skin treated with sulfur mustard. Toxicol Appl Pharmacol. 2018;355:52-59 pubmed publisher
    ..pattern of cytokines/chemokine expression was coordinate with expression of macrophage elastase/MMP12 and neutrophil collagenase/MMP8 suggesting that macrophages and neutrophils were, at least in part, a source of cytokines and ..
    ..The report also provides a reference for further studies on dentine caries microbiology and dentine caries collagen degradation mechanisms, both of which are known only in part. ..
  25. Chen X, Xie L, Liu Y, Chen D, Yu Q, Gan X, et al. Metabolic Syndrome and Periodontal Disease Among Civilian Pilots. Aerosp Med Hum Perform. 2016;87:1016-1020 pubmed publisher
    ..Chen X, Xie L, Liu Y, Chen D, Yu Q, Gan X, Yu H. Metabolic syndrome and periodontal disease among civilian pilots. Aerosp Med Hum Perform. 2016; 87(12):1016-1020. ..
  26. Sakamuri S, Takawale A, Basu R, Fedak P, Freed D, Sergi C, et al. Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure. Transl Res. 2016;172:30-44 pubmed publisher
    ..However, persistent elevation of matricellular proteins such as SPARC could contribute to the relapse of failing hearts on removal of LVAD support. ..
  27. Pradhan Palikhe P, Vesterinen T, Tarkkanen J, Leivo I, Sorsa T, Salo T, et al. Plasma level of tissue inhibitor of matrix metalloproteinase-1 but not that of matrix metalloproteinase-8 predicts survival in head and neck squamous cell cancer. Oral Oncol. 2010;46:514-8 pubmed publisher
    ..Plasma TIMP-1 levels predict survival in HNSCC. TIMP-1 expression is genetically controlled in women. As TIMP-1 inhibits the activity of MMP-8 and it also functions as a growth factor, it may directly influence HNSCC progression. ..
  28. Chen B, Li Y, Eisenstatt J, Runge K. Identification of a lifespan extending mutation in the Schizosaccharomyces pombe cyclin gene clg1+ by direct selection of long-lived mutants. PLoS ONE. 2013;8:e69084 pubmed publisher
    ..mutants in culture allowed identification of a long-lived mutant bearing an insertion mutation in the cyclin gene clg1(+). Clg1p, like Pas1p, physically associates with the cyclin-dependent kinase Pef1p...
  29. Scherpenhuizen A, van Waes A, Janssen L, Van Cann E, Stegeman I. The effect of exercise therapy in head and neck cancer patients in the treatment of radiotherapy-induced trismus: A systematic review. Oral Oncol. 2015;51:745-50 pubmed publisher the head and neck area is identified as one of the most frequent causes of trismus in head and neck cancer (HNC) patients. Currently, there is no standard treatment for trismus...
  30. Nakamura H, Fujii Y, Ohuchi E, Yamamoto E, Okada Y. Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases. Eur J Biochem. 1998;253:67-75 pubmed
  31. Amarasena I, Herschtal A, D Costa I, Fua T, Tiong A, Geddes V, et al. Outcomes of Routine Intensity Modulated Radiation Therapy Quality Assurance in a Large Head and Neck Cancer Center. Int J Radiat Oncol Biol Phys. 2017;98:541-546 pubmed publisher
    ..the perceived value of the program by the compliance of radiation oncologists (ROs) treating head and neck cancer (HNC). This was a retrospective analysis of a prospective database for all radically treated HNC patients...
  32. Zhang Y, Koneva L, Virani S, Arthur A, Virani A, Hall P, et al. Subtypes of HPV-Positive Head and Neck Cancers Are Associated with HPV Characteristics, Copy Number Alterations, PIK3CA Mutation, and Pathway Signatures. Clin Cancer Res. 2016;22:4735-45 pubmed publisher
    There is substantial heterogeneity within human papillomavirus (HPV)-associated head and neck cancer (HNC) tumors that predispose them to different outcomes; however, the molecular heterogeneity in this subgroup is poorly characterized ..
  33. Nightingale C, Pereira D, Curbow B, Wingard J, Carnaby G. A Prospective Biopsychosocial Investigation Into Head and Neck Cancer Caregiving. Biol Res Nurs. 2016;: pubmed
    Head and neck cancer (HNC) patients suffer from significant morbidity, which may introduce challenging care demands and subsequent stress-induced mind-body interactions for informal caregivers...
  34. Yushi Q, Li Z, von Roemeling C, Doeppler H, Marlow L, Kim B, et al. Osteopontin is a multi-faceted pro-tumorigenic driver for central nervous system lymphoma. Oncotarget. 2016;7:32156-71 pubmed publisher
    ..These results implicate OPN as a candidate for development of targeted therapy for patients with PCNSL. ..
  35. Daly M, Atkinson S, Varisco B, Klingbeil L, Hake P, Lahni P, et al. Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion. FASEB J. 2016;30:3453-3460 pubmed
    ..C., Atkinson, S. J., Varisco, B. M., Klingbeil L., Hake, P., Lahni, P., Piraino, G., Wu, D., Hogan, S. P., Zingarelli, B., Wong, H. R. Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion. ..
  36. Breen L, O Connor M, Calder S, Tai V, Cartwright J, Beilby J. The health professionals' perspectives of support needs of adult head and neck cancer survivors and their families: a Delphi study. Support Care Cancer. 2017;25:2413-2420 pubmed publisher
    ..of Australian and New Zealand health professionals regarding the support needs of people with head and neck cancer (HNC) and their families and current gaps in service delivery...
  37. Salminen A, Vlachopoulou E, Havulinna A, Tervahartiala T, Sattler W, Lokki M, et al. Genetic Variants Contributing to Circulating Matrix Metalloproteinase 8 Levels and Their Association With Cardiovascular Diseases: A Genome-Wide Analysis. Circ Cardiovasc Genet. 2017;10: pubmed publisher
    b>Matrix metalloproteinase 8 (MMP-8) is a proinflammatory enzyme expressed mainly by neutrophils. Elevated serum and plasma concentrations of MMP-8 are associated with the risk for and outcome of cardiovascular diseases (CVDs)...
  38. Hsiao C, Liu L, Shih T, Chuang C, Chen G, Wang H, et al. The Association of Matrix Metalloproteinase-8 Promoter Genotypes in Breast Cancer. Anticancer Res. 2018;38:2181-2185 pubmed
    ..MMP8 -799C/T, Val436Ala and Lys460Thr polymorphisms may only play an indirect role in determining personal cancer susceptibility to breast cancer in Taiwan. ..
  39. Betz M, Huxley P, Davies S, Mushtaq Y, Pieper M, Tschesche H, et al. 1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile. Eur J Biochem. 1997;247:356-63 pubmed
    ..Human neutrophil collagenase represents one of the three interstitial collagenases that cleave triple-helical collagen of type I, II ..
  40. Ohlstein J, Brody Camp S, Friedman S, Levy J, Buell J, Friedlander P. Initial Experience of a Patient Navigation Model for Head and Neck Cancer. JAMA Otolaryngol Head Neck Surg. 2015;141:804-9 pubmed publisher
    Specific temporal goals for treatment of head and neck cancer (HNC) are common in Europe but not in the United States...
  41. van Hooren M, Leunis N, Brandsma D, Dingemans A, Kremer B, Kross K. Differentiating head and neck carcinoma from lung carcinoma with an electronic nose: a proof of concept study. Eur Arch Otorhinolaryngol. 2016;273:3897-3903 pubmed
    ..There seems to be a potential for e-nose as a diagnostic tool in HNC and lung carcinoma. With a fair diagnostic accuracy, an e-nose can differentiate between the two tumor entities.
  42. Kadouche D, Ducatez M, Cenci U, Tirtiaux C, Suzuki E, Nakamura Y, et al. Characterization of Function of the GlgA2 Glycogen/Starch Synthase in Cyanobacterium sp. Clg1 Highlights Convergent Evolution of Glycogen Metabolism into Starch Granule Aggregation. Plant Physiol. 2016;171:1879-92 pubmed publisher
    ..b>CLg1 synthesizes both glycogen and starch...
  43. Whiteside T. Head and Neck Carcinoma Immunotherapy: Facts and Hopes. Clin Cancer Res. 2018;24:6-13 pubmed publisher
    Cancer of the head and neck (HNC) is a heterogeneous disease of the upper aerodigestive tract, encompassing distinct histologic types, different anatomic sites, and human papillomavirus (HPV)-positive as well as HPV-negative cancers...
  44. McNiff M, Haynes E, Dixit N, Gao F, Laurence J. Thioredoxin fusion construct enables high-yield production of soluble, active matrix metalloproteinase-8 (MMP-8) in Escherichia coli. Protein Expr Purif. 2016;122:64-71 pubmed publisher
    ..SDS-PAGE, densitometry, mass spectrometry, circular dichroism spectroscopy and an activity assay were used to analyze the chemical integrity and function of the enzyme. ..
  45. De Felice F, Benevento I, Musella A, Musio D, Tombolini V. Metronomic chemotherapy in head and neck cancer. Cancer Lett. 2017;400:219-222 pubmed publisher
    Head neck cancer (HNC) is generally treated with a multimodality approach. Loco-regional-distant control is often worst, due to the advantage stage disease at diagnosis and the optimal treatment option remains an unresolved issue...
  46. De Felice F, De Vincentiis M, Luzzi V, Magliulo G, Tombolini M, Ruoppolo G, et al. Late radiation-associated dysphagia in head and neck cancer patients: evidence, research and management. Oral Oncol. 2018;77:125-130 pubmed publisher
    In head and neck cancer (HNC) scenario, newer radiotherapy (RT) techniques, such as intensity modulated RT (IMRT), aim to reduce acute and late toxicity without impair tumor response and loco-regional control rates...
  47. Barak V, Meirovitz A, Leibovici V, Rachmut J, Peretz T, Eliashar R, et al. The Diagnostic and Prognostic Value of Tumor Markers (CEA, SCC, CYFRA 21-1, TPS) in Head and Neck Cancer Patients. Anticancer Res. 2015;35:5519-24 pubmed
    ..CEA, SCC, TPS and CYFRA 21-1 can all serve as useful tumor markers in HNC patients. They assessed response to therapy and were prognostic for recurrence...
  48. Deng J, Dietrich M, Ridner S, Fleischer A, Wells N, Murphy B. Preliminary evaluation of reliability and validity of head and neck external lymphedema and fibrosis assessment criteria. Eur J Oncol Nurs. 2016;22:63-70 pubmed publisher
    ..Sixty head and neck cancer (HNC) patients who were ?3-month post cancer therapy were recruited...
  49. Gahlaut A, Paranjothy M. Unimolecular decomposition of formamide via direct chemical dynamics simulations. Phys Chem Chem Phys. 2018;20:8498-8505 pubmed publisher
    ..The major dissociation products observed were NH3, CO, H2, HNCO, H2O, HCN, and HNC along with products of a few minor dissociation channels...
  50. Wen G, Zhang C, Chen Q, Luong L, Mustafa A, Ye S, et al. A Novel Role of Matrix Metalloproteinase-8 in Macrophage Differentiation and Polarization. J Biol Chem. 2015;290:19158-72 pubmed publisher
    ..The data indicate a previously unknown role of MMP8 in M2-Mφ polarization by cleaving fibromodulin and therefore increasing the bioavailability of the M2-Mφ inducer TGF-β. ..
  51. Zhou Z, Wang M, Li J, Xiao M, Chin Y, Cheng J, et al. SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer. Oncogene. 2016;35:5826-5838 pubmed publisher
    ..of transcription 3 (STAT3) has been found in various types of human cancers, including head and neck cancer (HNC)...
  52. Mazzola R, Ricchetti F, Fiorentino A, Giaj Levra N, Fersino S, Tebano U, et al. Fentanyl pectin nasal spray for painful mucositis in head and neck cancers during intensity-modulated radiation therapy with or without chemotherapy. Clin Transl Oncol. 2017;19:593-598 pubmed publisher
    ..was to evaluate the effectiveness and tolerability of rapid onset opioid in a cohort of head and neck cancer (HNC) patients affected by painful mucositis influencing swallowing function during RT ± ChT with definitive or ..
  53. Rosendahl J, Holmlund Suila E, Helve O, Viljakainen H, Hauta Alus H, Valkama S, et al. 25-hydroxyvitamin D correlates with inflammatory markers in cord blood of healthy newborns. Pediatr Res. 2017;81:731-735 pubmed publisher
    ..We studied the concentrations of inflammatory markers, matrix metalloproteinase 8 (MMP-8) and high sensitivity CRP (hs-CRP), and 25-hydroxyvitamin D (25(OH)D) in cord blood of 939 ..
  54. Fang C, Wen G, Zhang L, Lin L, Moore A, Wu S, et al. An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo. Cardiovasc Res. 2013;99:146-55 pubmed publisher
    ..Our findings provide new insights into the molecular mechanisms of plaque angiogenesis and suggest that MMP8 is a potential therapeutic target of cardiovascular diseases. ..
  55. Kim S, Romero R, Lee J, Chaemsaithong P, Lee M, Chaiyasit N, et al. About one-half of early spontaneous preterm deliveries can be identified by a rapid matrix metalloproteinase-8 (MMP-8) bedside test at the time of mid-trimester genetic amniocentesis. J Matern Fetal Neonatal Med. 2016;29:2414-22 pubmed publisher
    ..accumulated data suggest that the determination of amniotic fluid matrix metalloproteinase-8 (MMP-8), or neutrophil collagenase, is a powerful predictor of spontaneous preterm delivery...
  56. Teng F, Aryal M, Lee J, Lee C, Shen X, Hawkins P, et al. Adaptive Boost Target Definition in High-Risk Head and Neck Cancer Based on Multi-imaging Risk Biomarkers. Int J Radiat Oncol Biol Phys. 2018;102:969-977 pubmed publisher
    ..MRI), and diffusion-weighted MRI each identify unique risk factors for treatment outcomes in head and neck cancer (HNC). Clinical trials in HNC largely rely on a single imaging modality to define targets for boosting...
  57. Chiu C, Chang M, Chiang C, Hahn L, Hsieh L, Chen C. Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis. Cancer Epidemiol Biomarkers Prev. 2002;11:646-53 pubmed
    ..These results imply that susceptibility to OSF could involve multigenic mechanisms modified by the betel quid-exposure dose. ..
  58. Burrow J, Koch J, Chuang H, Zhong W, Dean D, Sylvia V. Nitric oxide donors selectively reduce the expression of matrix metalloproteinases-8 and -9 by human diabetic skin fibroblasts. J Surg Res. 2007;140:90-8 pubmed
    ..One possible mechanism to account for NO's beneficial effect on wound healing may involve stimulation of cell proliferation and down-regulation of MMP expression. ..
  59. Godoy Santos A, Trevisan R, Fernandes T, Santos M. Association of MMP-8 polymorphisms with tendinopathy of the primary posterior tibial tendon: a pilot study. Clinics (Sao Paulo). 2011;66:1641-3 pubmed
  60. Sterba K, Zapka J, Lapelle N, Garris T, Buchanan A, Scallion M, et al. Development of a survivorship needs assessment planning tool for head and neck cancer survivors and their caregivers: a preliminary study. J Cancer Surviv. 2017;11:822-832 pubmed publisher
    The purpose of this study was to characterize primary end-of-treatment challenges in head and neck cancer (HNC) to drive the development of a survivorship needs assessment planning (SNAP) tool and evaluate its acceptability and ..
  61. Qiu Z, Zhang F, Gong C, Xu H, Hu J. Fusion Peptides CPU1 and CPU2 Inhibit Matrix Metalloproteinases and Protect Mice from Endotoxin Shock Within a Strict Time Window. Inflammation. 2015;38:2092-104 pubmed publisher
  62. Dodd R, Forster A, Waller J, Marlow L. Discussing HPV with oropharyngeal cancer patients: A cross-sectional survey of attitudes in health professionals. Oral Oncol. 2017;68:67-73 pubmed publisher
    Human papillomavirus (HPV) is now known to cause a significant proportion of head and neck cancers (HNC)...
  63. Giuliani M, Milne R, McQuestion M, Sampson L, Le L, Jones J, et al. Partner's survivorship care needs: An analysis in head and neck cancer patients. Oral Oncol. 2017;71:113-121 pubmed publisher
    To determine the number, type and predictors of unmet needs for head and neck cancer (HNC) survivors' partner's. Partners of HNC patients were invited to complete the Cancer Survivors' Partners Unmet Needs Survey (CaSPUN)...
  64. Tanaka M, Sasaki K, Kamata R, Sakai R. The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. J Cell Sci. 2007;120:2179-89 pubmed
    ..Our results suggest a novel function of the C-terminus of ephrin-B1 in activating MMP-8 secretion, which promotes the invasion of cancer cells. ..
  65. Allal Elasmi M, Zayani Y, Zidi W, Zaroui A, Feki M, Mourali S, et al. The measurement of circulating matrix metalloproteinase-8 and its tissue inhibitor and their association with inflammatory mediators in patients with acute coronary syndrome. Clin Lab. 2014;60:951-6 pubmed
    ..In addition, the strong relationship with MMP-8 and inflammatory mediators such as CRP, fibrinogen and WBC in ACS patients suggests that MMP-8 might be an additional marker and/or consequence of inflammatory components in ACS. ..
  66. Park C, Park J, Jun J, Yoon B. The inflammatory milieu of amniotic fluid in acute-chorioamnionitis decreases with increasing gestational age. Placenta. 2015;36:1283-90 pubmed publisher
    ..071, P = 0.170). AF MMP-8 concentrations in acute-chorioamnionitis distinctly decrease throughout preterm-gestation. This finding suggests that the inflammatory milieu of AF decrease in acute-chorioamnionitis with GA. ..
  67. Chen Y, Wang J, Pan C, Li D, Han X. Microcystin-leucine-arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cell Mol Life Sci. 2018;75:1117-1132 pubmed publisher
    ..This work may provide new perspectives in developing new diagnosis and treatment strategies for MC-induced male infertility. ..
  68. Sun D, Zhang X, Zhang X. miR-146a C/G polymorphism increased the risk of head and neck cancer, but overall cancer risk: an analysis of 89 studies. Biosci Rep. 2018;38: pubmed publisher
    Several studies have evaluated the association of miR-146a C/G with head and neck cancer (HNC) susceptibility, and overall cancer risk, but with inconclusive outcomes...
  69. Woo M, Patterson E, Cepinskas G, Clarson C, Omatsu T, Fraser D. Dynamic regulation of plasma matrix metalloproteinases in human diabetic ketoacidosis. Pediatr Res. 2016;79:295-300 pubmed publisher
    ..Thus, leukocyte-derived MMPs might contribute to DKA-associated cerebrovascular complications. ..
  70. van Nieuwenhuizen A, Buffart L, van Uden Kraan C, van der Velden L, Lacko M, Brug J, et al. Patient-reported physical activity and the association with health-related quality of life in head and neck cancer survivors. Support Care Cancer. 2018;26:1087-1095 pubmed publisher
    ..of life (HRQoL) adjusted for important demographic, lifestyle-related, and clinical factors, among head and neck (HNC) survivors. This cross-sectional study included 116 HNC survivors...
  71. Macann A, Fauzi F, Simpson J, Sasso G, Krawitz H, Fraser Browne C, et al. Humidification mitigates acute mucosal toxicity during radiotherapy when factoring volumetric parameters. Trans Tasman Radiation Oncology Group (TROG) RadioHUM 07.03 substudy. Oral Oncol. 2017;75:75-80 pubmed publisher
    ..based humidification use and mucositis symptom burden during radiotherapy (RT) for head and neck cancer (HNC) when factoring in volumetric radiotherapy parameters derived from tumour and normal tissue regions of interest...
  72. Marchant D, Bellac C, Moraes T, Wadsworth S, Dufour A, Butler G, et al. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat Med. 2014;20:493-502 pubmed publisher
    ..These findings suggest that inhibiting extracellular MMP-12 could be a new avenue for the development of antiviral treatments...
  73. Ferris M, Zhong J, Switchenko J, Higgins K, Cassidy R, McDonald M, et al. Brainstem dose is associated with patient-reported acute fatigue in head and neck cancer radiation therapy. Radiother Oncol. 2018;126:100-106 pubmed publisher
    ..nervous system (CNS) has been implicated as a contributor to treatment-related fatigue in head and neck cancer (HNC) patients undergoing radiation therapy (RT)...
  74. Leibowitz A, Grossman E, Berkovitch A, Levartovski M, Appel S, Sharabi Y, et al. The Effect of Head and Neck Radiotherapy on Blood Pressure and Orthostatic Hypotension in Patients With Head and Neck Tumors. Am J Hypertens. 2017;: pubmed publisher
    Radiotherapy (RT) plays a key role in the management of head and neck cancer (HNC), especially in locally advanced disease...
  75. Mena M, Lloveras B, Tous S, Bogers J, Maffini F, Gangane N, et al. Development and validation of a protocol for optimizing the use of paraffin blocks in molecular epidemiological studies: The example from the HPV-AHEAD study. PLoS ONE. 2017;12:e0184520 pubmed publisher
    ..In the context of an international study on head and neck cancer (HNC)-HPV-AHEAD, a standardized protocol for optimizing the use of FFPEs in molecular epidemiology was developed and ..
  76. Tringale K, Carroll K, Zakeri K, Sacco A, Barnachea L, Murphy J. Cost-effectiveness Analysis of Nivolumab for Treatment of Platinum-Resistant Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck. J Natl Cancer Inst. 2017;: pubmed publisher
    ..141 trial found that nivolumab improved survival for patients with recurrent or metastatic head and neck cancer (HNC). Despite the improved survival, nivolumab is much more expensive than standard therapies...
  77. Stams T, Spurlino J, Smith D, Wahl R, Ho T, Qoronfleh M, et al. Structure of human neutrophil collagenase reveals large S1' specificity pocket. Nat Struct Biol. 1994;1:119-23 pubmed
    The crystal structure of the catalytic domain of human neutrophil collagenase complexed with a peptide transition state analogue has been determined to a resolution of 2.1 A...
  78. Kostamo K, Sorsa T, Leino M, Tervahartiala T, Alenius H, Richardson M, et al. In vivo relationship between collagenase-2 and interleukin-8 but not tumour necrosis factor-alpha in chronic rhinosinusitis with nasal polyposis. Allergy. 2005;60:1275-9 pubmed
    ..The IL-8 and MMP-8 seemingly form an inductive cytokine-proteinase cascade in CRSwNP pathogenesis. Together they provide a target for novel therapies and a diagnostic tool for monitoring CRSwNP treatment. ..
  79. Kushlinskii N, Solovykh E, Karaoglanova T, Bayar U, Gershtein E, Troshin A, et al. Content of matrix metalloproteinase-8 and matrix metalloproteinase-9 in oral fluid of patients with chronic generalized periodontitis. Bull Exp Biol Med. 2011;152:240-4 pubmed
    ..The depth of the periodontal pocket was shown to be the most reliable clinical sign for the state of periodontal tissues. A strong correlation was revealed between this criterion and MMP-9 content in oral fluid. ..
  80. Craig V, Polverino F, Laucho Contreras M, Shi Y, Liu Y, Osorio J, et al. Mononuclear phagocytes and airway epithelial cells: novel sources of matrix metalloproteinase-8 (MMP-8) in patients with idiopathic pulmonary fibrosis. PLoS ONE. 2014;9:e97485 pubmed publisher
    ..Plasma and BALF MMP-8 levels are unlikely to serve as a prognostic biomarker for IPF patients. These results provide new information about the expression patterns of MMP-8 in IPF patients. ..
  81. Mian S, Yorucu C, Ullah M, Rehman I, Colley H. Raman spectroscopy can discriminate between normal, dysplastic and cancerous oral mucosa: a tissue-engineering approach. J Tissue Eng Regen Med. 2017;11:3253-3262 pubmed publisher
    Head and neck cancer (HNC) is the sixth most common malignancy worldwide. Squamous cell carcinoma, the primary cause of HNC, evolves from normal epithelium through dysplasia before invading the connective tissue to form a carcinoma...
  82. Blaser J, Knauper V, Osthues A, Reinke H, Tschesche H. Mercurial activation of human polymorphonuclear leucocyte procollagenase. Eur J Biochem. 1991;202:1223-30 pubmed
    ..Thus PMNL procollagenase activation by HgCl2 followed a three-step activation mechanism which is entirely different from the known activation mechanisms of the fibroblast matrix metalloproteinases. ..
  83. Massova I, Kotra L, Fridman R, Mobashery S. Matrix metalloproteinases: structures, evolution, and diversification. FASEB J. 1998;12:1075-95 pubmed
    ..Analysis indicates that a retrograde structure simplification may have accounted for the evolution of MMPs with simple domain constituents, such as matrilysin, from the larger and more elaborate enzymes. ..
  84. Qin G, Luo M, Chen J, Dang Y, Chen G, Li L, et al. Reciprocal activation between MMP-8 and TGF-β1 stimulates EMT and malignant progression of hepatocellular carcinoma. Cancer Lett. 2016;374:85-95 pubmed publisher
    ..Therefore, the reciprocal positive interplay between MMP-8 and TGF-β1 contributes to HCC invasion and metastasis by inducing EMT mainly through the PI3K/Akt/Rac1 pathway. ..
  85. Schmalz G, Davarpanah I, Jager J, Mausberg R, Krohn Grimberghe B, Schmidt J, et al. MMP-8 and TIMP-1 are associated to periodontal inflammation in patients with rheumatoid arthritis under methotrexate immunosuppression - First results of a cross-sectional study. J Microbiol Immunol Infect. 2017;: pubmed publisher
    ..Prevalence of selected periodontal pathogenic bacteria and concentration of matrix metalloproteinase 8 (MMP-8) was assessed from the gingival crevicular fluid (GCF) using PCR and ELISA, respectively...
  86. Nakahara Y, Miyata T, Hamuro T, Funatsu A, Miyagi M, Tsunasawa S, et al. Amino acid sequence and carbohydrate structure of a recombinant human tissue factor pathway inhibitor expressed in Chinese hamster ovary cells: one N-and two O-linked carbohydrate chains are located between Kunitz domains 2 and 3 and one N-linked car. Biochemistry. 1996;35:6450-9 pubmed
    ..These results indicated that the region is occupied by a cluster of three bulky and acidic carbohydrate chains. ..
  87. Turu M, Krupinski J, Catena E, Rosell A, Montaner J, Rubio F, et al. Intraplaque MMP-8 levels are increased in asymptomatic patients with carotid plaque progression on ultrasound. Atherosclerosis. 2006;187:161-9 pubmed
    ..03, CI 95% 0.7-1.0). Hypoechogenic carotid plaques had increased MMP activity and asymptomatic patients with plaque progression show increase intraplaque MMP-8 levels. ..
  88. Schaaf B, Liebau C, Kurowski V, Droemann D, Dalhoff K. Hospital acquired pneumonia with high-risk bacteria is associated with increased pulmonary matrix metalloproteinase activity. BMC Pulm Med. 2008;8:12 pubmed publisher
    ..Pulmonary MMP concentrations and MMP activity are elevated in patients with HAP. This effect is most pronounced in patients with high-risk bacteria. Artificial ventilation may play an additional role in protease activation. ..
  89. Kim B, Jeon Y, Nam M. A mechanism of apigenin-induced apoptosis is potentially related to anti-angiogenesis and anti-migration in human hepatocellular carcinoma cells. Food Chem Toxicol. 2011;49:1626-32 pubmed publisher
    ..Based on the overall results, we suggested that vimentin was potentially associated with APG-induced apoptosis, as a key regulator in angiogenesis and migration. ..
  90. Jacobs C, Walter C, Ziebart T, Grimm S, Meila D, Krieger E, et al. Induction of IL-6 and MMP-8 in human periodontal fibroblasts by static tensile strain. Clin Oral Investig. 2014;18:901-8 pubmed publisher
    ..Furthermore, this study points out that the strength of force plays a pivotal role to achieve orthodontic tooth movement without inducing periodontal inflammation and to activate extracellular matrix regeneration. ..
  91. Moz S, Basso D, Padoan A, Bozzato D, Fogar P, Zambon C, et al. Blood expression of matrix metalloproteinases 8 and 9 and of their inducers S100A8 and S100A9 supports diagnosis and prognosis of PDAC-associated diabetes mellitus. Clin Chim Acta. 2016;456:24-30 pubmed publisher
    ..015). An increased expression of tissue and blood MMP9 reflects the presence of PDAC-associated diabetes mellitus. This finding fits with the hypothesized role of MMPs as part of the complex network linking cancer to diabetes. ..
  92. Hung Y, Tsai C, Wu C, Shih L, Chen Y, Liu Y, et al. The Contribution of Matrix Metalloproteinase-8 Promoter Polymorphism to Oral Cancer Susceptibility. In Vivo. 2017;31:585-590 pubmed
    ..Our findings suggest that the polymorphisms at MMP-8 C-799T or Val436Ala may not play a major role in mediating personal risk of oral cancer; however, the detailed mechanisms require further investigation. ..