MMP-7

Summary

Gene Symbol: MMP-7
Description: matrix metallopeptidase 7
Alias: MMP-7, MPSL1, PUMP-1, matrilysin, matrin, matrix metallopeptidase 7 (matrilysin, uterine), matrix metalloproteinase 7 (matrilysin, uterine), matrix metalloproteinase-7, pump-1 protease, uterine matrilysin, uterine metalloproteinase
Species: human

Top Publications

  1. doi Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells
    Ta Kashi Ito
    Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
    Blood 113:2363-9. 2009
  2. doi The influence of transforming growth factor-α, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer
    Marcello Ferretti Fanelli
    Fundacao Antonio Prudente, Hospital do Cancer A C Camargo, Sao Paulo, Brazil
    Histopathology 61:153-61. 2012
  3. ncbi Current evidence on associations between the MMP-7 (-181A>G) polymorphism and digestive system cancer risk
    Pan Ke
    Department of General Surgery, Xiang Ya 2nd Hospital, Central South University, Chang Sha, Hunan, China
    Asian Pac J Cancer Prev 14:2269-72. 2013
  4. ncbi Metalloproteinase-1, metalloproteinase-7, and p53 immunoexpression and their correlation with clinicopathological prognostic factors in colorectal adenocarcinoma
    Benicio L B B P Nunes
    Coloproctology Service, Hospital Santa Casa de Misericórdia de Maceió, Alagoas, Brazil
    Int J Biol Markers 24:156-64. 2009
  5. ncbi [Change of matrix metalloproteinase-1 and matrix metalloproteinase-7 in serum and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and sarcoidosis]
    Le fei Zhou
    Institute of Respiratory Disease, First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Jie He He Hu Xi Za Zhi 33:441-4. 2010
  6. ncbi Matrix metalloproteinases 2, 7, and 9 and tissue inhibitor of metalloproteinases-1 in tumors and serum of patients with ovarian neoplasms
    E S Gershtein
    N N Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
    Bull Exp Biol Med 149:628-31. 2010
  7. doi MMP-7 (-181A>G) promoter polymorphisms and risk for cervical cancer
    Hariom Singh
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
    Gynecol Oncol 110:71-5. 2008
  8. ncbi Activin A enhances MMP-7 activity via the transcription factor AP-1 in an esophageal squamous cell carcinoma cell line
    Keiji Yoshinaga
    Department of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Int J Oncol 33:453-9. 2008
  9. pmc Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer
    Ming Shi
    Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing 100850, PR China
    Mol Cancer 9:269. 2010
  10. pmc Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1
    H P Marti
    Department of Medicine, San Francisco VAMC University of California, San Francisco 94121
    Biochem J 285:899-905. 1992

Research Grants

  1. QD-BRET nanosensors for protease detection and imaging
    Jianghong Rao; Fiscal Year: 2012
  2. Conor C Lynch; Fiscal Year: 2014
  3. Steven R Van Doren; Fiscal Year: 2014
  4. Transcriptional regulation of matrix metalloproteinases in colon epithelial cells
    Guofeng Xie; Fiscal Year: 2012
  5. Lipid Nanoparticle Mediated Inhibition and Detection of Matrix Metalloproteinases
    Sanku Mallik; Fiscal Year: 2012
  6. Metalloproteinases in Tumor Progression and Metastasis
    Jeffrey Smith; Fiscal Year: 2009
  7. Expression, hormonal regulation and function of microRNA in leiomyoma
    GREGORY SCOTT SCHULTZ; Fiscal Year: 2012
  8. MOLECULAR MECHANISMS OF ANEURYSMAL DEGENERATION
    Robert Thompson; Fiscal Year: 2009
  9. Airway Metalloproteinases in Mucosal Immunity
    CAROLE LYNN WILSON; Fiscal Year: 2010
  10. Ivan O Rosas; Fiscal Year: 2014

Detail Information

Publications203 found, 100 shown here

  1. doi Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells
    Ta Kashi Ito
    Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
    Blood 113:2363-9. 2009
    ..These data suggest that VEGF escapes the sequestration by endothelial sVEGFR-1 and promotes angiogenesis in the presence of MMP-7...
  2. doi The influence of transforming growth factor-α, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer
    Marcello Ferretti Fanelli
    Fundacao Antonio Prudente, Hospital do Cancer A C Camargo, Sao Paulo, Brazil
    Histopathology 61:153-61. 2012
    ....
  3. ncbi Current evidence on associations between the MMP-7 (-181A>G) polymorphism and digestive system cancer risk
    Pan Ke
    Department of General Surgery, Xiang Ya 2nd Hospital, Central South University, Chang Sha, Hunan, China
    Asian Pac J Cancer Prev 14:2269-72. 2013
    ..26, 95% CI=1.02-1.51), and dominant model (GG/GA vs. AA, OR=1.18, 95% CI=1.08-1.55). Our findings suggest that the MMP-7 (-181A>G) polymorphism may be a risk factor for digestive system cancer, especially among Asian populations...
  4. ncbi Metalloproteinase-1, metalloproteinase-7, and p53 immunoexpression and their correlation with clinicopathological prognostic factors in colorectal adenocarcinoma
    Benicio L B B P Nunes
    Coloproctology Service, Hospital Santa Casa de Misericórdia de Maceió, Alagoas, Brazil
    Int J Biol Markers 24:156-64. 2009
    ..The aim of this study was to analyze the immunoexpression of metalloproteinase-1, metalloproteinase-7, and p53 in colorectal adenocarcinoma, and to correlate this with clinicopathological prognostic factors...
  5. ncbi [Change of matrix metalloproteinase-1 and matrix metalloproteinase-7 in serum and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and sarcoidosis]
    Le fei Zhou
    Institute of Respiratory Disease, First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Jie He He Hu Xi Za Zhi 33:441-4. 2010
    ....
  6. ncbi Matrix metalloproteinases 2, 7, and 9 and tissue inhibitor of metalloproteinases-1 in tumors and serum of patients with ovarian neoplasms
    E S Gershtein
    N N Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
    Bull Exp Biol Med 149:628-31. 2010
    ....
  7. doi MMP-7 (-181A>G) promoter polymorphisms and risk for cervical cancer
    Hariom Singh
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
    Gynecol Oncol 110:71-5. 2008
    Matrix metalloproteinase (MMP-7) is a secreted matrilysin, which contributes to tumor progression through breakdown of basement membranes and angiogenesis...
  8. ncbi Activin A enhances MMP-7 activity via the transcription factor AP-1 in an esophageal squamous cell carcinoma cell line
    Keiji Yoshinaga
    Department of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Int J Oncol 33:453-9. 2008
    ..Moreover, the expression of c-Jun was increased in Act-betaA transfectants. These results indicate that activin A may modulate the expression of MMP-7 via AP-1 and not through Smad2/3...
  9. pmc Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer
    Ming Shi
    Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing 100850, PR China
    Mol Cancer 9:269. 2010
    ....
  10. pmc Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1
    H P Marti
    Department of Medicine, San Francisco VAMC University of California, San Francisco 94121
    Biochem J 285:899-905. 1992
    ..Mesangial synthesis of PUMP-1 may contribute to the progression of injury during glomerular inflammatory states...
  11. ncbi Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites
    H Nakamura
    Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 0016, Japan
    J Biol Chem 275:38885-90. 2000
    ....
  12. ncbi HIV-1 Tat neurotoxicity is prevented by matrix metalloproteinase inhibitors
    J B Johnston
    Department of Clinical Neuroscience, University of Calgary, Canada
    Ann Neurol 49:230-41. 2001
    ..005). These findings indicate that Tat causes neuronal death through an indirect mechanism that is Tat sequence dependent and involves the induction of MMPs...
  13. ncbi Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer
    K Hovanes
    Microbiology and Molecular Genetics Department, University of California, Irvine, Irvine, California, USA
    Nat Genet 28:53-7. 2001
    ....
  14. ncbi Serum matrix metalloproteinase 7 levels identifies poor prognosis advanced colorectal cancer patients
    Joan Maurel
    Medical Oncology Service, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, CIBERehd Universitat de Barcelona, Catalonia, Spain
    Int J Cancer 121:1066-71. 2007
    ..In conclusion, MMP-7 is an independent prognostic factor for survival in advanced CRC. In our sample, the risk of death associated to MMP-7 increase is much higher than the risk of death associated to lactate dehydrogenase elevation...
  15. pmc Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity
    Peter Chen
    Center for Lung Biology, University of Washington School of Medicine, Seattle, WA 98109, USA
    Am J Pathol 172:1256-70. 2008
    ..Furthermore, in a mouse model of OB, airway obliteration is reduced in TIMP-1-deficient mice. Matrilysin (matrix metallproteinase-7) is essential for airway epithelial repair and is required for the re-..
  16. ncbi Role of PTEN and MMP-7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma
    Hua Chuan Zheng
    The 4th Laboratory, Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, China
    Pathol Int 53:659-66. 2003
    ..Close correlation between PTEN on MMP-7 expression provided a novel insight into the regulatory effects of PTEN on MMP-7 expression in gastric carcinoma...
  17. pmc Expression of heparanase gene, CD44v6, MMP-7 and nm23 protein and their relationship with the invasion and metastasis of gastric carcinomas
    Jun qiang Chen
    Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong Province, China
    World J Gastroenterol 10:776-82. 2004
    ..To explore the expression of heparanase gene, CD44v6, MMP-7 and nm23 proteins in human gastric carcinoma as well as their relationship with the clinicopathological factors...
  18. ncbi (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells
    Mihye Kim
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Carcinogenesis 26:1553-62. 2005
    Matrix metalloproteinase (MMP)-7 (matrilysin-1) plays significant roles in the growth, invasion, and metastasis of colorectal tumors, while (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol with chemopreventive properties, has ..
  19. ncbi Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium
    Xiao Yang Wang
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Lab Invest 87:527-39. 2007
    ..The collective results suggest a novel model of BOA formation via hASH1-induced suppression of the apoptotic pathway. Our study yields a promising new preclinical tool for chemoprevention of peripheral lung carcinomas...
  20. ncbi Overexpression of matrix metalloproteinase-7 (MMP-7) correlates with tumor proliferation, and a poor prognosis in non-small cell lung cancer
    DaGe Liu
    Second Department of Surgery, Faculty of Medicine, Kagawa University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    Lung Cancer 58:384-91. 2007
    ..We performed a retrospective study on the MMP-7 expression in non-small cell lung cancer (NSCLC) according to the clinical characteristics, biological markers and the Wnt1 expression...
  21. doi Matrilysin inhibits proliferation and modulates sensitivity of lung cancer cells to FasL-mediated apoptosis
    Hui Liu
    Department of Internal Medicine, Division of Pulmonary and Critical Care, The Third Affiliated Hospital of Sun Yat Sen University, No 600, Tianhe Street, Guangzhou, 510630, China
    Med Oncol 25:419-30. 2008
    Matrix metalloproteinase (MMP) family member MMP-7 (matrilysin) cleaves various cell-surface proteins to alter their effector functions in addition to a broad substrate specificity against extracellular matrix components...
  22. ncbi Clinicopathological significance of the gene expression of matrix metalloproteinase-7, insulin-like growth factor-1, insulin-like growth factor-2 and insulin-like growth factor-1 receptor in patients with colorectal cancer: insulin-like growth factor-1 re
    Takashi Oshima
    Yokohama City University Medical Center, Gastroenterological Center, Kanagawa ken 232 0024, Japan
    Oncol Rep 20:359-64. 2008
    ..IGF-1R gene expression is thus considered a useful predictor of liver metastasis from colorectal cancer...
  23. pmc Genetic polymorphisms in the MMP-7 gene and breast cancer survival
    Alicia Beeghly-Fadiel
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Int J Cancer 124:208-14. 2009
    ..9) and TT (OS HR: 0.3, 95% CI: 0.1-0.8) fared better than patients with AA (p-value for trend: 0.001). Thus, common MMP-7 genetic polymorphisms were found to be significant determinants of survival among Chinese women with breast cancer...
  24. ncbi Expression of MMP-7, MMP-9, TIMP-1 and TIMP-2 mRNA in lung tissue of patients with non-small cell lung cancer (NSCLC) and benign pulmonary disease
    J Safranek
    Departments of Surgery, Faculty of Medicine in Pilsen, Charles University in Prague, University Hospital in Pilsen, Czech Republic
    Anticancer Res 29:2513-7. 2009
    ....
  25. pmc MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis
    Helen Williams
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Research Floor Level 7, Upper Maudlin St, Bristol BS2 8HW, UK
    Cardiovasc Res 87:137-46. 2010
    ..We previously showed that cell-cell contacts mediated by N-cadherin reduce VSMC apoptosis. This study aimed to determine whether matrix-degrading metalloproteinase (MMP)-dependent N-cadherin cleavage causes VSMC apoptosis...
  26. doi Elevated serum matrix metalloproteinase 7 levels predict poor prognosis after radical prostatectomy
    Tibor Szarvas
    Department of Urology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Int J Cancer 128:1486-92. 2011
    ..In clinically localized prostate cancer, MMP-7 may provide independent prognostic information, thereby helping to optimize therapy decisions...
  27. pmc Dimerumic acid inhibits SW620 cell invasion by attenuating H₂O₂-mediated MMP-7 expression via JNK/C-Jun and ERK/C-Fos activation in an AP-1-dependent manner
    Bing Ying Ho
    Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Int J Biol Sci 7:869-80. 2011
    ..Our data suggest that DMA may be useful in minimizing the development of colorectal metastasis. In the future, DMA supplementation may be a beneficial antioxidant to enhance surgical outcomes...
  28. doi Antisense oligonucleotide targeting matrix metalloproteinase-7 (MMP-7) changes the ultrastructure of human A549 lung adenocarcinoma cells
    Bo Yang
    Department of Oncology, Wuhan General Hospital of Guangzhou Command PLA, 627 Wuluo Road, Wuhan, P R China
    Ultrastruct Pathol 35:256-9. 2011
    ..Collectively, the findings identified the morphological mechanism that MMP-7 ASODN inhibited proliferation and invasion in A549 cells...
  29. ncbi Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line
    K Miyazaki
    Kihara Institute for Biological Research, Yokohama City University, Kanagawa, Japan
    Cancer Res 50:7758-64. 1990
    ..Based on the fact that this enzyme is secreted extracellularly and degrades the matrix proteins, we propose the name "matrin" for this newly identified enzyme.
  30. ncbi Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members
    B Quantin
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Strasbourg, France
    Biochemistry 28:5327-34. 1989
    ..On the basis of this observation, its size, and its substrate specificity, we suggest that pump-1 might correspond to a previously described uterine metalloproteinase, matrix metalloproteinase 7.
  31. ncbi Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties
    K Imai
    Department of Molecular Immunology and Pathology, Kanazawa University, Japan
    J Biol Chem 270:6691-7. 1995
    b>Matrix metalloproteinase 7 (MMP-7) has been purified as an inactive zymogen of M(r) 28,000 (proMMP-7) from the culture medium of CaR-1 human rectal carcinoma cells...
  32. ncbi Matrilysin is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1-antitrypsin
    U I Sires
    Department of Medicine, Washington University School of Medicine, Jewish Hospital, St Louis, MO 63110
    Biochem Biophys Res Commun 204:613-20. 1994
    ..In this report, we describe the catalytic effects of matrilysin, a recently identified metalloproteinase, upon alpha 1-antitrypsin...
  33. pmc Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release
    K Imai
    Department of Molecular Immunology and Pathology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920, Japan
    Biochem J 322:809-14. 1997
    ..metalloproteinases (MMPs): MMP-1 (tissue collagenase), MMP-2 (gelatinase A), MMP-3 (stromelysin 1), MMP-7 (matrilysin) and MMP-9 (gelatinase B). MMP-2 and MMP-3 digest DCN into seven major fragments in a similar pattern...
  34. ncbi Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9)
    B C Patterson
    Department of Chemistry, Florida State University, Tallahassee, Florida 32306 4390, USA
    J Biol Chem 272:28823-5. 1997
    ..Here we demonstrate that two members of the human matrix metalloproteinase (MMP) family, matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9), hydrolyze human plasminogen to generate angiostatin ..
  35. ncbi Accumulation of matrilysin (MMP-7) and macrophage metalloelastase (MMP-12) in actinic damage
    U Saarialho-Kere
    Department of Dermatology, Helsinki University Central Hospital, Finland
    J Invest Dermatol 113:664-72. 1999
    ..and in situ hybridization, we have studied the localization of two elastolytic matrix metalloproteinases, matrilysin (matrix metalloproteinase-7) and human macrophage metalloelastase (matrix metalloproteinase-12) in solar damage...
  36. ncbi Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin)
    R Agnihotri
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    J Biol Chem 276:28261-7. 2001
    ..We report that OPN is a novel substrate for two MMPs, MMP-3 (stromelysin-1) and MMP-7 (matrilysin). Three cleavage sites were identified for MMP-3 in human OPN, and two of those sites were also cleaved by MMP-7...
  37. ncbi Allele-specific regulation of matrix metalloproteinase-7 promoter activity is associated with coronary artery luminal dimensions among hypercholesterolemic patients
    S Jormsjö
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Department of Medicine, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 21:1834-9. 2001
    ....
  38. ncbi Matrix metalloproteinase-7 expression in colorectal cancer liver metastases: evidence for involvement of MMP-7 activation in human cancer metastases
    Zhao Shi Zeng
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 8:144-8. 2002
    ..The aim of this study is to examine the MMP-7 expression in the human colorectal cancer (CRC) liver metastases and normal liver tissue using multiple techniques and to determine its association with liver metastases formation...
  39. pmc CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling
    Wei Hsuan Yu
    Molecular Pathology Unit, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129, USA
    Genes Dev 16:307-23. 2002
    ..We demonstrate here that CD44 heparan sulfate proteoglycan (CD44HSPG) recruits proteolytically active matrix metalloproteinase 7 (matrilysin, MMP-7) and heparin-binding epidermal growth factor precursor (pro-HB-EGF) to form a complex ..
  40. ncbi Prognostic significance of matrix metalloproteinase-7 (MMP-7) expression at the invasive front in gastric carcinoma
    Xiu Ping Liu
    Department of Pathology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Jpn J Cancer Res 93:291-5. 2002
    ..12; P = 0.0019, RR = 2.67, respectively). Our findings indicated that expression of MMP-7 at the invasive front is closely associated with local invasiveness, and might be a reliable prognostic marker for patients with gastric carcinoma...
  41. pmc Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans
    Fengrong Zuo
    Roche Bioscience, Palo Alto, CA 94304 Functional Genomics, and Institute of Respiratory Medicine, Sheba Medical Center, Tel Hashomer, 52621 Israel
    Proc Natl Acad Sci U S A 99:6292-7. 2002
    ..Using a combined set of scoring systems we determined that matrilysin (matrix metalloproteinase 7), a metalloprotease not previously associated with pulmonary fibrosis, was the most informative ..
  42. ncbi Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand
    Tracy Vargo-Gogola
    Department of Cancer Biology, Vanderbilt University, 736 PRB 23rd and Pierce, Nashville, TN 37232 6840, USA
    Arch Biochem Biophys 408:155-61. 2002
    ..We conclude that the controversy regarding the biological activity of sFasL may be explained, in part, by the generation of distinct forms of sFasL as a result of cleavage at specific sequences...
  43. pmc Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium
    John K McGuire
    Department of Pediatrics, Washington University School of Medicine, St Louis, USA
    Am J Pathol 162:1831-43. 2003
    b>Matrilysin (matrix metalloproteinase-7) is highly expressed in lungs of patients with pulmonary fibrosis and other conditions associated with airway and alveolar injury...
  44. ncbi Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration
    Lydia E Wroblewski
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    J Cell Sci 116:3017-26. 2003
    Epithelial cell responses to bacterial infection include induction of matrix metalloproteinase 7 (MMP-7)...
  45. ncbi Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: increased expression of matrix metalloproteinase-7 predicts poor survival
    Lucie E Jones
    Department of Surgery, University of Liverpool, Liverpool, United Kingdom
    Clin Cancer Res 10:2832-45. 2004
    ..To enable the design of improved inhibitors of matrix metalloproteinases (MMPs) for the treatment of pancreatic cancer, the expression profiles of a range of MMPs and tissue inhibitors of MMPs (TIMPs) were determined...
  46. ncbi Expression spectra of matrix metalloproteinases in metastatic non-small cell lung cancer
    Torng Sen Lin
    Department of Surgery, Chang Hua Christian Hospital, and Institute of Medicine, Chang Shan Medical University, Taichung, Taiwan
    Oncol Rep 12:717-23. 2004
    ..Therefore, it should be worth determining MMP expression pattern as a regimen reference for NSCLC patients who were scheduled to receive MMP inhibitor, which was class-specific, as adjuvant therapeutic agent...
  47. ncbi Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase
    Feng Qiang Wang
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
    Int J Cancer 114:19-31. 2005
    Although matrilysin (MMP-7) is overexpressed in various malignancies, few studies have evaluated its role in epithelial ovarian cancer (EOC) invasion and metastasis...
  48. ncbi The functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma
    Jianhui Zhang
    Hebei Cancer Institute, Hebei Medical University, Jiankanglu 12, Shijiazhuang 050011, Hebei Province, China
    Carcinogenesis 26:1748-53. 2005
    ....
  49. ncbi Targeting matrilysin and its impact on tumor growth in vivo: the potential implications in breast cancer therapy
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Clin Cancer Res 11:6012-9. 2005
    b>Matrilysin (MMP-7) is a metalloproteinase that is involved in the degradation of extracellular matrix, invasion, and tumor progression...
  50. ncbi Polymorphisms in the promoter regions of the matrix metalloproteinases-1, -3, -7, and -9 and the risk of epithelial ovarian cancer in China
    Yan Li
    Hebei Cancer Institute, Hebei Medical University, Jiankanglu 12, Shijiazhuang 050011, Hebei Province, China
    Gynecol Oncol 101:92-6. 2006
    ....
  51. pmc Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells
    Kan Ding
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697
    J Cell Biol 171:729-38. 2005
    ..These results support a specific role for shed syndecan-1 or MMP7-syndecan-1 complexes in tumor progression and add to accumulating evidence that syndecans and glypicans have nonequivalent functions in vivo...
  52. pmc Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study
    Julio Rodriguez-Lopez
    Research Laboratory 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Arthritis Res Ther 8:R1. 2006
    ....
  53. ncbi Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection
    Stephan Hellmig
    Department of General Internal Medicine, University Hospital of Schleswig Holstein, Campus Kiel, Germany
    Am J Gastroenterol 101:29-35. 2006
    ..The aim of this study was to investigate if genetic variants in MMPs involved in the inflammatory response to H. pylori could predispose patients with chronic H. pylori infection to develop gastric ulcer disease...
  54. ncbi Regulation of matrilysin expression in endothelium by fibroblast growth factor-2
    Wolfgang Holnthoner
    Department of Dermatology, Division of General Dermatology, Medical University of Vienna, Vienna, Austria
    Biochem Biophys Res Commun 342:725-33. 2006
    b>Matrilysin (MMP7) is a secreted matrix metalloproteinase, which contributes to angiogenesis by breaking down basement membranes. We show that the angiogenic factor FGF-2 induces MMP7 expression in human endothelial cells...
  55. ncbi Prognostic significance of matrix metalloproteinase-7 in epithelial ovarian cancer and its relation to beta-catenin expression
    Sari M Sillanpää
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Kuopio, Kuopio, Finland
    Int J Cancer 119:1792-9. 2006
    ..The present study showed that intense MMP-7 signal in tumor cells is an independent prognostic factor predicting better survival in epithelial ovarian cancer...
  56. pmc Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer
    F J G M Kubben
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Cancer 95:744-51. 2006
    ..We conclude that MMP-related SNPs, especially MMP-7(-181A>G) and TIMP-2(303C>T), may be helpful in identifying gastric cancer patients with a poor clinical outcome...
  57. pmc Estrogen decrease in tight junctional resistance involves matrix-metalloproteinase-7-mediated remodeling of occludin
    George I Gorodeski
    Department of Reproductive Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Endocrinology 148:218-31. 2007
    ..These mechanisms acting in concert could be important for regulation and control of estrogen modulation of paracellular permeability in vivo...
  58. pmc Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma
    Astrid Lievre
    INSERM U775 et Université René Descartes, Paris, France
    BMC Cancer 6:270. 2006
    ....
  59. ncbi Matrilysin 1 influences colon carcinoma cell migration by cleavage of the laminin-5 beta3 chain
    Lionel Remy
    Institut National de la Sante et de la Recherche Medicale, U 45 IFR62, Universite Claude Bernard Lyon I, France
    Cancer Res 66:11228-37. 2006
    Matrilysin 1 [matrix metalloproteinase 7 (MMP7)] is one of the most important metalloproteinases expressed in human tissues...
  60. ncbi High gene expression of matrix metalloproteinase-7 is associated with early stages of oral cancer
    Eleftherios Vairaktaris
    Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Attikon Hospital, Athens, Greece
    Anticancer Res 27:2493-8. 2007
    ..In the light of the recently found contribution of matrix metalloproteinases (MMPs) to oral oncogenesis, the correlation of MMP-7 with risk for oral cancer was investigated...
  61. doi HER2-dependent MMP-7 expression is mediated by activated STAT3
    Guogang Yuan
    Institute of Basic Medical Sciences, Beijing 100850, PR China
    Cell Signal 20:1284-91. 2008
    ..The data indicate that HRG-induced HER2-dependent transcriptional upregulation and protein secretion of MMP-7 are mediated by activated STAT3. The expression of MMP-7 may be attributed to HER2/STAT3 activation...
  62. doi Plasma matrix metalloproteinase-7 as a metastatic marker and survival predictor in patients with renal cell carcinomas
    Azizbek Ramankulov
    Department of Urology, Charite University Hospital, Berlin, Germany
    Cancer Sci 99:1188-94. 2008
    ..81, 95% CI, 2.77-12.2; P < 0.0001) as independent determinants of cancer-related survival outcomes. In conclusion, increased plasma MMP-7 could be related to metastatic disease and poor prognosis in patients with RCC...
  63. doi Heregulin-beta promotes matrix metalloproteinase-7 expression via HER2-mediated AP-1 activation in MCF-7 cells
    Guogang Yuan
    Institute of Basic Medical Sciences, Beijing, 100850, People s Republic of China
    Mol Cell Biochem 318:73-9. 2008
    ..The data indicate a close link among HRG-beta stimulation, HER signaling, and AP-1 activation. Our data suggest that HRG-beta-induced MMP-7 expression was regulated by HER2-mediated AP-1 activation in MCF-7 cells...
  64. pmc Common MMP-7 polymorphisms and breast cancer susceptibility: a multistage study of association and functionality
    Alicia Beeghly-Fadiel
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203 1738, USA
    Cancer Res 68:6453-9. 2008
    ..Results from our study suggest that common MMP-7 genetic polymorphisms may contribute to breast cancer susceptibility...
  65. pmc p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7
    Seth R Ogden
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Mol Biol Cell 19:4110-21. 2008
    ..These results indicate that selective and coordinated induction of mmp-7 expression by H. pylori cag(+) isolates may explain in part the augmentation in gastric cancer risk associated with these strains...
  66. doi Predictive value of MMP-7 expression for response to chemotherapy and survival in patients with non-small cell lung cancer
    Hui Liu
    Department of Internal Medicine, Division of Pulmonary and Critical Care, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Cancer Sci 99:2185-92. 2008
    ..49 P = 0.001). These findings suggest that the expression level of MMP-7 in tumor cells is predictive of response to chemotherapy and outcome in patients with advanced NSCLC receiving platinum-based chemotherapy...
  67. doi Active matrix metalloproteinase-7 is associated with invasion in buccal squamous cell carcinoma
    Hui Ching Chuang
    Department of Otolaryngology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Niao Song Hsiang, Kaohsiung, Taiwan
    Mod Pathol 21:1444-50. 2008
    ..036). In conclusion, active matrix metalloproteinase-7 expression was associated with more aggressive buccal squamous cell carcinomas...
  68. doi Genetic polymorphisms of matrix metalloproteinases: susceptibility and prognostic implications for prostate cancer
    Sabrina Thalita Dos Reis
    Urology Department, Laboratory of Medical Investigation, Faculdade de Medicina da Universidade de Sao Paulo, Brazil
    J Urol 181:2320-5. 2009
    ..We investigated the correlation between MMP1, 2, 7 and 9 polymorphisms with susceptibility to prostate cancer, and classic prognostic parameters of prostate cancer...
  69. ncbi Three-dimensional culture using a radial flow bioreactor induces matrix metalloprotease 7-mediated EMT-like process in tumor cells via TGFbeta1/Smad pathway
    Shun Ichi Shibata
    Department of Biochemistry, Jikei University School of Medicine, Minato ku, Tokyo 105 8461, Japan
    Int J Oncol 34:1433-48. 2009
    ..Cells in the RFB overexpressed matrix metalloproteinase 7 (MMP7) and showed an increased release of soluble 80-kDa fragments of E-cadherin into the media time-..
  70. doi Fecal cyclooxygenase 2 plus matrix metalloproteinase 7 mRNA assays as a marker for colorectal cancer screening
    Tetsunari Takai
    First Department of Medicine, Hamamatsu University School of Medicine, Enshu Hospital, Hamamatsu, Japan
    Cancer Epidemiol Biomarkers Prev 18:1888-93. 2009
    ..To further improve the sensitivity, we evaluated the usefulness of the combination of COX-2 mRNA and matrix metalloproteinase 7 (MMP-7) mRNA assays as a marker of CRC...
  71. pmc Matrilysin-1 mediates bronchiolization of alveoli, a potential premalignant change in lung cancer
    Xiao Yang Wang
    Experimental Pathology Section, Cell and Cancer Biology Branch, CCR, NCI, NIH, 37 Convent Drive Room 1056B, Bethesda, Maryland 20892, USA
    Am J Pathol 175:592-604. 2009
    b>Matrilysin-1 (also called matrix metalloproteinase-7) is expressed in injured lung and in cancer but not in normal epithelia...
  72. doi Meta-analysis of association between matrix metalloproteinases 2, 7 and 9 promoter polymorphisms and cancer risk
    Bo Peng
    State Key Laboratory of Genetic Engineering, Department of Genetics, Institute of Genetics, School of Life Science, Fudan University, Shanghai, People s Republic of China
    Mutagenesis 25:371-9. 2010
    ..Large case-control studies should be performed to clarify the possible roles of these four polymorphisms in different kinds of cancer in more detail...
  73. doi IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells
    Samuel J Wadsworth
    UBC James Hogg Research Laboratories, Providence Heart and Lung Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 126:366-74, 374.e1-8. 2010
    ..Interaction of Fas receptor (CD95) with its ligand (FasL; CD95L) is an important mechanism of cell-mediated apoptosis. Bronchial epithelial FasL expression provides immune barrier protection from immune cell-mediated damage...
  74. pmc Bladder cancer risk associated with genotypic polymorphism of the matrix metalloproteinase-1 and 7 in North Indian population
    Priyanka Srivastava
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India
    Dis Markers 29:37-46. 2010
    ..This study provided new support for the association of MMP1-1607 and MMP7-181 in bladder cancer development, the tumorigenic effect of which was observed to be more enhanced in case of tobacco exposure...
  75. doi Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip
    Simone Souza Lobão Veras Barros
    Department of Pathology and Clinical Dentistry, Federal University of Piaui, Teresina, PI, Brazil
    Arch Oral Biol 56:752-60. 2011
    ..To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy...
  76. doi Overexpression of matrix metalloproteinase-7 and -9 in NSCLC tumor and stromal cells: correlation with a favorable clinical outcome
    Helge Stenvold
    Institute of Clinical Medicine, University of Tromso, Norway
    Lung Cancer 75:235-41. 2012
    ..As both malignant cells and cells of the surrounding stroma contribute to tumor growth, we have explored the impact of MMP-2, -7 and -9 expression in both the tumor and stromal compartment of non-small-cell lung cancers (NSCLC)...
  77. doi Thermodynamic analysis of ionizable groups involved in the catalytic mechanism of human matrix metalloproteinase 7 (MMP-7)
    Hitoshi Takeharu
    Kyoto University, Kyoto, Japan
    Biochim Biophys Acta 1814:1940-6. 2011
    Human matrix metalloproteinase 7 (MMP-7) exhibits a broad bell-shaped pH-dependence with the acidic and alkaline pK(e) (pK(e1) and pK(e2)) values of about 4 and 10...
  78. doi Fibulin-3 promoter methylation alters the invasive behavior of non-small cell lung cancer cell lines via MMP-7 and MMP-2 regulation
    Eun Jin Kim
    Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, 1045 Daedeok daero, Yusong gu, Daejeon 305 353, Republic of Korea
    Int J Oncol 40:402-8. 2012
    ..These results indicate that fibulin-3 is a negative regulator of invasiveness in NSCLC and further studies are needed for its therapeutic applications in treatment of NSCLC...
  79. doi Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell
    Zhi Chao Jia
    Laboratory of Colon Cancer, First Hospital of Peking University, no 8, Xishiku Street, West District, Beijing, 100034, China
    Int J Colorectal Dis 27:437-45. 2012
    ..MMP-7 overexpression is believed to play an important role in tumor invasion and metastasis. The aim of this study is to elucidate the molecular mechanisms by which TF/FVIIa induced MMP-7 expression and cell invasion in vitro...
  80. doi Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells
    Su Kyung Lee
    Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Yuseonggu, Daejon, Republic of Korea
    Int J Cancer 131:E190-203. 2012
    ..These results suggest that the migration and invasion of PRL-3-expressing CRC cells depends primarily on the expression of MMP-7...
  81. ncbi Expression and prognostic value of matrix metalloproteinase-7 in colorectal cancer
    Bo Yang
    Department of Oncology, Wuhan General Hospital of Guangzhou Command PLA, Wuhan, China
    Asian Pac J Cancer Prev 13:1049-52. 2012
    ..Collectively, we found MMP-7 expression to be correlated with progression and metastasis of CRC and thus could be used as a predictive marker of prognosis in CRC patients...
  82. ncbi Clinical significance of MMP-7 and PTEN expression in colorectal cancer
    Zheng Bi
    Department of Clinical Laboratory, Qilu Hospital of Shandong University, Shandong Province, China
    Hepatogastroenterology 60:32-6. 2013
    ..The aim of this study was to investigate the expression of MMP-7 and PTEN protein in colorectal cancer and explore its correlation with clinicopathological parameters...
  83. pmc ETS variant 1 regulates matrix metalloproteinase-7 transcription in LNCaP prostate cancer cells
    Sook Shin
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Oncol Rep 29:306-14. 2013
    ..Together, these results showed that MMP-7 is a bona fide ETV1 target gene, implicating that MMP-7 upregulation is partially responsible for the oncogenic effects of ETV1 in the prostate...
  84. ncbi Structure and expression of the human gene for the matrix metalloproteinase matrilysin
    M Gaire
    Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232
    J Biol Chem 269:2032-40. 1994
    b>Matrilysin, a member of the matrix metalloproteinase family, is structurally different from the other matrix metalloproteinases by virtue of the absence of a conserved COOH-terminal protein domain...
  85. doi Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors
    Hiroshi Matono
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582 Japan
    Hum Pathol 39:1802-8. 2008
    ..We further examined messenger RNA expression of matrix metalloproteinase 7 by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and compared the results with ..
  86. doi Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer
    Y J Fang
    Department of Colorectal Surgery, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Int J Colorectal Dis 24:875-84. 2009
    ..Colorectal cancer is one of the most common cancers worldwide. We tested the hypothesis that differences in the expression of certain molecular markers of colon cancer may account for different clinical outcomes...
  87. doi Elevated serum matrix metalloproteinase-3 and -7 in H. pylori-related gastric cancer can be biomarkers correlating with a poor survival
    Yi Chun Yeh
    Institute of Basic Medical Sciences, National Cheng Kung University Medical Center, Tainan, Taiwan
    Dig Dis Sci 55:1649-57. 2010
    ..This study aimed to test if serum levels of MMP-3, -7, and -9 are correlated with different clinical outcomes in H. pylori-infected subjects and if these are predictive of progression to H. pylori-related gastric cancer...
  88. ncbi CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer
    Hirokazu Okayama
    Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    Oncol Rep 22:745-55. 2009
    ..Combined evaluation of these markers could be further useful to predict lymph node status clinically...
  89. pmc Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinases as novel stress markers in children and young adults on chronic dialysis
    Kinga Musiał
    Department of Pediatric Nephrology, Wrocław Medical University, M Skłodowskiej Curie 50 52, Wrocław, Poland
    Cell Stress Chaperones 16:163-71. 2011
    ....
  90. ncbi Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion
    Christine Rivat
    INSERM U 482, Hopital Saint Antoine, 75571, Paris Cedex 12, France
    FASEB J 17:1721-3. 2003
    The matrix metalloprotease matrilysin is expressed in premalignant polyps and plays a key role in local invasion during the progression of digestive tumors...
  91. ncbi Matrix metalloproteinase-7 increases resistance to Fas-mediated apoptosis and is a poor prognostic factor of patients with colorectal carcinoma
    Wei Shu Wang
    Division of Medical Oncology, Department of Medicine Division of Colorectal Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Carcinogenesis 27:1113-20. 2006
    ....
  92. ncbi Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2
    Jean Luc Brun
    Departments of Gynecology, AP HP, Hopital Tenon, 4 rue de la Chine, F 75571 Paris Cedex, France
    Int J Oncol 33:1239-46. 2008
    ..In conclusion, our results support the differential expression in MMPs and TIMPs of ovarian tumors according to serous or mucinous histology...
  93. ncbi Clinicopathological assessment and quantitative estimation of the matrix metalloproteinases MMP-2 and MMP-7 and the inhibitors TIMP-1 and TIMP-2 in colorectal carcinoma tissue samples
    M Pesta
    Central Laboratory of Radioisotopes, Charles University and Faculty Hospital, Pilsen, Czech Republic
    Anticancer Res 27:1863-7. 2007
    ..The aim of our study was to test the levels of MMP-2, MMP-7, and the MMP inhibitors TIMP-1 and TIMP-2 mRNA in colorectal carcinoma tissue samples with the clinicopathological status of the disease...
  94. doi Effect of 1, 25 dihydroxyvitamin D(3) on matrix metalloproteinases MMP-7, MMP-9 and the inhibitor TIMP-1 in pulmonary tuberculosis
    S Prabhu Anand
    Department of Immunology, Tuberculosis Research Centre, Indian Council of Medical Research, Mayor V R Ramanathan Road, Chennai 600 031, India
    Clin Immunol 133:126-31. 2009
    ..The present study suggests that 1, 25(OH)(2)D(3) may probably play an important role in the pathological process in tuberculosis by downregulating the levels of MMPs and upregulating the levels of TIMPs...
  95. ncbi Corneal neovascularization after excimer keratectomy wounds in matrilysin-deficient mice
    Tomoko Kure
    Massachusetts Eye and Ear Infirmary and Schepens Eye Research Institute, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 44:137-44. 2003
    b>Matrilysin, matrix metalloproteinase (MMP)-7, is upregulated in the corneal epithelium during wound healing after excimer keratectomy wounds...
  96. ncbi Experimental studies on the effects of recombinant human matrix metalloproteinases on herniated disc tissues--how to facilitate the natural resorption process of herniated discs
    Hirotaka Haro
    Department of Orthopaedic Surgery, Suwa Central Hospital, 4300 Tamagawa, Chino, Nagano 391 8503, Japan
    J Orthop Res 23:412-9. 2005
    ..We therefore examined the role of these recombinant human matrix metalloproteinases (rh MMPs) in the treatment of herniated discs...
  97. doi The role of matrix metalloproteinases in recurrent tonsillitis
    Engin Acioglu
    Department of Otolaryngology, Istanbul Training and Research Hospital, Turkey
    Int J Pediatr Otorhinolaryngol 74:535-9. 2010
    ....
  98. ncbi Clinicopathologic and prognostic significance of matrix metalloproteinases in rectal cancer
    O Schwandner
    Department of Surgery, Caritas Krankenhaus St Josef, Landshuter Strasse 65, 93053 Regensburg, Germany
    Int J Colorectal Dis 22:127-36. 2007
    ..The aim of this study was to determine the prognostic role of matrix metalloproteinases in rectal cancer...
  99. doi Degradation of tropoelastin by matrix metalloproteinases--cleavage site specificities and release of matrikines
    Andrea Heinz
    Institute of Pharmacy, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    FEBS J 277:1939-56. 2010
    ..Furthermore, the generated peptides YTTGKLPYGYGPGG, YGARPGVGVGGIP, and PGFGAVPGA, containing GxxPG motifs that have not yet been proven to be bioactive, were identified as new matrikines upon biological activity testing...
  100. ncbi [Expression of matrix metalloproteinases in the cytotrophoblasts and decidual stromal cells in human early pregnancy]
    Xiao heng He
    Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1136-9. 2006
    ....
  101. pmc Role of matrix metalloproteinases in colorectal carcinogenesis
    M J Heslin
    Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Alabama 35243, USA
    Ann Surg 233:786-92. 2001
    ..To measure coexpression of matrix metalloproteinase (MMP)-2, MMP-7, and MMP-9 genes by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) in benign and malignant phases of colorectal carcinogenesis...

Research Grants54

  1. QD-BRET nanosensors for protease detection and imaging
    Jianghong Rao; Fiscal Year: 2012
    ..A responsible for the degradation of type IV collagen, the main component of extracellular matrix;MMP-7, matrilysin, the smallest member with broad proteolytic activity;and urokinase-type plasminogen activator (uPA) that ..
  2. Conor C Lynch; Fiscal Year: 2014
    ..abstract_text> ..
  3. Steven R Van Doren; Fiscal Year: 2014
    ..The binding modes will reveal unique functional epitopes and sites where future MMP-specific antibodies can be targeted to interfere in these associations in diagnostic, research, and therapeutic uses. ..
  4. Transcriptional regulation of matrix metalloproteinases in colon epithelial cells
    Guofeng Xie; Fiscal Year: 2012
    ..Xie to develop a novel, clinically important research focus and learn important experimental methods and academic skills thereby laying a solid foundation for an independent research career. ..
  5. Lipid Nanoparticle Mediated Inhibition and Detection of Matrix Metalloproteinases
    Sanku Mallik; Fiscal Year: 2012
    ..The successful completion of this research will establish foundation for developing diagnostic and therapeutic tools for other proteins responsible for causing different human diseases. ..
  6. Metalloproteinases in Tumor Progression and Metastasis
    Jeffrey Smith; Fiscal Year: 2009
    ..These chemical leads will be improved by iterative structure-based modifications and will be tested in cell-based assays and ultimately in animal models of tumor progression. ..
  7. Expression, hormonal regulation and function of microRNA in leiomyoma
    GREGORY SCOTT SCHULTZ; Fiscal Year: 2012
    ..This proposal will investigate how fibroids grow and ways to prevent their symptoms and growth. ..
  8. MOLECULAR MECHANISMS OF ANEURYSMAL DEGENERATION
    Robert Thompson; Fiscal Year: 2009
    ..of eiastase-induced AAAs, if MMP-9 is directly responsible for aortic wall elastin degradation in vivo, and if matrilysin (MMP-7) is required for aneurysmal degeneration;(2) Establish if MMP-mediated degradation of interstitial (type ..
  9. Airway Metalloproteinases in Mucosal Immunity
    CAROLE LYNN WILSON; Fiscal Year: 2010
    ..b>Matrilysin, a matrix metalloproteinase (MMP), functions in innate immunity and facilitates re-epithelialization and ..
  10. Ivan O Rosas; Fiscal Year: 2014
    ..Successful completion of this study will provide the basis for the design of a more definitive phase III clinical trial of low dose inhaled CO in IPF. (End of Abstract) ..
  11. David J Lederer; Fiscal Year: 2014
    ..We propose to validate a novel imaging biomarker of early-stage IPF and perform the first genetic studies of early IPF to identify new therapeutic targets to prevent lung fibrosis. ..
  12. Determining how trichloroethylene alters CD4+ T cell function
    Kathleen M Gilbert; Fiscal Year: 2012
    ..Consequently, demonstrating that a common water pollutant such as trichloroethylene can cause this effect and describing the mechanism for it could have important implications for human health. ..
  13. CHELSEA SHIELDS BAHNEY; Fiscal Year: 2014
    ..abstract_text> ..
  14. MECHANISMS IN THE REMODELING OF LUNG STRUCTURE
    Michael J Holtzman; Fiscal Year: 2012
    ..Focal points of the proposed studies will be laminin-332 (laminin-5), surfactant protein D (SP-D), matrilysin (MMP-7), serglycin, and a distinct population of non-B non-T (NBNT) lymphoid cells...
  15. Matrilysin regulation in colonic epithelial cells and role in barrier function
    John Kwon; Fiscal Year: 2011
    ..Our preliminary data implicates matrix metalloproteinase-7 (matrilysin) in the pathogenesis of inflammatory cytokine-induced altered barrier resistance...
  16. Role of Wnt/b-catenin signaling in pulmonary fibrosis
    AI P LAM; Fiscal Year: 2013
    ..The findings from this proposal will provide novel insights into the molecular mechanism for this disease and translate into the development of desperately needed therapeutics for pulmonary fibrosis. (End of Abstract) ..
  17. LOUIS JUSTINE VUGA; Fiscal Year: 2014
    ....
  18. Zongbing You; Fiscal Year: 2016
    ..significantly thicker in IL-17RC- mice, a finding that we have associated with a decreased expression of matrix metalloproteinase 7 (MMP7). Addition of a recombinant mouse IL-17 induced the expression of MMP7 in the mouse prostate...
  19. Activated nano-sized MR contrast agents for imaging of tumor proteolytic activity
    Dmitri Artemov; Fiscal Year: 2010
    ..These nanoscale activated MR contrast agents can improve existing imaging technology for early cancer detection and/or for noninvasive monitoring of tumor response to therapy. ..
  20. David H Broide; Fiscal Year: 2016
    ..In addition the availability of specimens from asthma and EE allow the findings to be translated to human subjects with remodeling. ..
  21. Youhua Liu; Fiscal Year: 2015
    ..The proposed studies may potentially have wide implications in designing future therapeutic regimens for the treatments of proteinuric kidney diseases. ..
  22. The Fate of dsRNA in the Nucleus
    Gordon Carmichael; Fiscal Year: 2006
    ..RNA binding protein p54nrb, the splicing factor PSF and the inner nuclear matrix structural protein matrin 3. This overall goal of this proposal is to learn more about this complex and its in vivo targets...
  23. MODULATION OF BETA-DEFENSINS BY MATRILYSIN
    Carole Wilson; Fiscal Year: 2001
    ..The proposed experiments should provide insight into the role of MMP-7 in mucosal epithelium and how this metalloenzyme contributes to mechanisms of host defense. ..
  24. Collagen XVIII in Corneal Neovascularization
    Jin Hong Chang; Fiscal Year: 2006
    ..The study of endostatin and MMP-7 in the cornea may provide valuable information about their possible clinical significance in corneal neovascularization and wound healing. ..
  25. Variation in Cytokine and MMP Genes and Risk of PPROM
    Pedro Ferrand; Fiscal Year: 2006
    ..Collectively, these studies could provide evidence for the contribution of genetic factors to the risk of preterm birth. ..
  26. MECHANISMS OF HEMORRHAGE AND EDEMA IN TPA STROKE THERAPY
    ENG LO; Fiscal Year: 2006
    ..This proposal should fit the goals of the Stroke PRG because it examines novel mechanisms that link tPA, cell signaling, MMPs, and hemorrhagic transformation in the neurovascular unit. ..
  27. MMP-7 and SNARE Cleavage in Neuroinflammation
    Katherine Conant; Fiscal Year: 2009
    ..The relevance of this research to Public Health is that it may explain how inflammation contributes to neurological dysfunction. Excess levels of select proteases may be considered as novel targets for neuro-protective drugs. ..
  28. Matrilsin and Tumor Progression
    Lynn Matrisian; Fiscal Year: 2006
    This application is a continuation of studies focused on the role of the matrix metalloproteinase MMP-7 (matrilysin) in colorectal cancer...
  29. MATRIX METALLOPROTEINASE AND APOPTOSIS IN BRAIN TRAUMA
    ENG LO; Fiscal Year: 2004
    ..To date, there are not effective treatments for traumatic brain injury. Results from these proposed experiments will help identify MMP and upstream MAP kinase pathways as viable therapeutic targets for this devastating condition. ..
  30. Novel optical probes fir in vivo imaging
    Ching Hsuan Tung; Fiscal Year: 2006
    ..abstract_text> ..
  31. Corneal Metalloproteinase-Matrix Interactions
    Mark Rosenblatt; Fiscal Year: 2009
    ..b>Matrilysin (MMP-7) deficient mice have exuberant scarring following laser injuries which are innocuous to their wild-type ..
  32. A Tumor Related NonTIMP Metalloproteinase Inhibitor
    MICHAEL BANDA; Fiscal Year: 2005
    ..These experiments will provide information regarding the control of metalloproteinase activity in tumor biology. ..
  33. Proteoglycans in Lung Inflammation and Fibrosis
    PYONG PARK; Fiscal Year: 2006
    ..abstract_text> ..
  34. MMP-7 IN Pacreatic Cancer and Chronic Pancreatitis
    Howard Crawford; Fiscal Year: 2008
    ..Overall, we expect these studies to contribute significantly to our knowledge of pancreatic tumor biology with immediate implications with regards to detection and treatment. ..
  35. MATRIXINS AND THEIR INHIBITORS IN ANGIOGENESIS
    QING XIANG SANG; Fiscal Year: 2002
    ..The role of each collagen-degrading matrixin in each step of angiogenesis in vitro will be assessed through intervention by the synthetic matrixin inhibitors. ..
  36. IL-1 and IL-1ra Stimulation of S aureus Replication
    SIVADASAN KANANGAT; Fiscal Year: 2003
    ..A better understanding of how bacteria such as S. aureus use IL-1 family of cytokines to replicate and defeat the host defense is highly relevant to the study of septic arthritis. ..
  37. MRI Study of Aggressive Individuals
    Ann Ragin; Fiscal Year: 2003
    ..Data obtained in this study will yield findings regarding brain structures potentially involved in impulsive aggression and provide insights concerning etiological factors in Intermittent Explosive Disorder. ..
  38. Analysis of the Chemopreventive Activity of FGN 1
    MARGIE CLAPPER; Fiscal Year: 2004
    ....
  39. DECIDUALIZATION IN THE BABOON
    Asgerally Fazleabas; Fiscal Year: 2003
    ....
  40. PHYSIOLOGY OF HUMAN RELAXIN
    Gerson Weiss; Fiscal Year: 2003
    ....
  41. 2004 Reproductive Tract Biology Gordon Conference
    Asgerally Fazleabas; Fiscal Year: 2004
    ..The continued ability to meet with the Mammalian Gametogenesis and Embryogenesis Conference at the same site will further enhance the quality of this meeting, which has consistently been highly rated by the attendees. ..
  42. Imaging gray matter structure in human auditory cortex
    Jennifer Melcher; Fiscal Year: 2004
    ..abstract_text> ..
  43. MITOCHONDRIA AND APOPTOSIS OF MAMMARY EPITHELIAL CELLS
    Barbara Heerdt; Fiscal Year: 2001
    ..abstract_text> ..
  44. Host Factors in Susceptibility to Chlamydial Disease
    KYLE RAMSEY; Fiscal Year: 2006
    ....
  45. Modeling ovarian cancer screening for CEA
    Nicole Urban; Fiscal Year: 2005
    ..Ultimately, an enhanced microsimulation model that incorporates new developments, innovations of the future as well as those we recognize today, will help guide policy and research investment decisions. ..
  46. Colon Cancer and Mitochondria
    Barbara Heerdt; Fiscal Year: 2006
    ..abstract_text> ..
  47. Matrilysin in Lung Epithelial Cell Migration
    John McGuire; Fiscal Year: 2007
    ..The current proposal addresses one potential mechanism by focusing on the function of matrilysin (MMP-7), a secreted matrix metalloproteinase (MMP), in lung epithelial cell migration...
  48. A Diffusion Tensor Imaging Study of HIV-Dementia
    Ann Ragin; Fiscal Year: 2006
    ..Experience gained during the proposed award will lay the foundation for further independent investigations of neurobiological factors in HIV-D. ..
  49. Regulation Paneth cell defensins by bacterial infection
    Nita Salzman; Fiscal Year: 2009
    ....
  50. Short chain fatty acid metabolism and colonic tumorigenesis
    Barbara Heerdt; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  51. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  52. Multifunctional low-density lipoprotein nanoplatforms
    Gang Zheng; Fiscal Year: 2008
    ..abstract_text> ..
  53. Estrogen and Aging effects on Transvaginal Transport
    George Gorodeski; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  54. Immunobiology of Lung Fibrosis
    Ana Mora; Fiscal Year: 2007
    ..4. Using IL-4 receptor deficient mice with and without adoptive transfer of normal Th2 cells, to determine whether IL-4 signaling in cells other than T lymphocytes is important to the lung fibrogenic response to MHV68 or bleomycin. ..