MMAA

Summary

Gene Symbol: MMAA
Description: methylmalonic aciduria (cobalamin deficiency) cblA type
Alias: cblA, methylmalonic aciduria type A protein, mitochondrial
Species: human

Top Publications

  1. ncbi Atypical methylmalonic aciduria: frequency of mutations in the methylmalonyl CoA epimerase gene (MCEE)
    Abigail B Gradinger
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Hum Mutat 28:1045. 2007
  2. ncbi Disproportionate distribution of Burkholderia cepacia complex species and transmissibility markers in cystic fibrosis
    J J LiPuma
    Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan 48109 0646, USA
    Am J Respir Crit Care Med 164:92-6. 2001
  3. pmc Complementation studies in the cblA class of inborn error of cobalamin metabolism: evidence for interallelic complementation and for a new complementation class (cblH)
    D Watkins
    Division of Medical Genetics, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    J Med Genet 37:510-3. 2000
  4. ncbi Short-column liquid chromatography with hydride generation atomic fluorescence detection for the speciation of arsenic
    X C Le
    Department of Public Health Sciences, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Anal Chem 70:1926-33. 1998
  5. doi Prediction of outcome in isolated methylmalonic acidurias: combined use of clinical and biochemical parameters
    F Horster
    Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children s Hospital Heidelberg, Im Neuenheimer Feld 430, D 69120, Heidelberg, Germany
    J Inherit Metab Dis 32:630-9. 2009
  6. ncbi Sensitive method for the determination of roxarsone using solid-phase microextraction with multi-detector gas chromatography
    Aaron R Roerdink
    Department of Chemistry, University of Wisconsin Milwaukee, Milwaukee, WI 53211 3029, USA
    J Chromatogr A 1057:177-83. 2004
  7. ncbi Bioaccessibility and excretion of arsenic in Niu Huang Jie Du Pian pills
    Iris Koch
    Environmental Sciences Group, PO Box 17000 Station Forces, Royal Military College of Canada, Kingston, Ontario, Canada K7K 7B4
    Toxicol Appl Pharmacol 222:357-64. 2007
  8. pmc Treatment of subsyndromal depressive symptoms in middle-aged and older adults with schizophrenia: effect on functioning
    John Kasckow
    VA Pittsburgh Health Care System MIRECC and Behavioral Health Service, 7180 Highland Dr, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 25:183-90. 2010
  9. ncbi Acquired and inherited disorders of cobalamin and folate in children
    V Michael Whitehead
    The Hematology Service, Montreal Children s Hospital and the McGill University Montreal Children s Hospital Research Institute of the McGill University Health Center, Montreal, QC, Canada
    Br J Haematol 134:125-36. 2006
  10. ncbi Speciation of five arsenic species (arsenite, arsenate, MMAAV, DMAAV and AsBet) in different kind of water by HPLC-ICP-MS
    Sébastien N Ronkart
    Gembloux Agricultural University, Unité de chimie analytique et Phytopharmacie, Passage des Deportes, 2, B 5030 Gembloux, Belgium
    Chemosphere 66:738-45. 2007

Research Grants

  1. A Radical Enzyme and its Escorts
    RUMA V BANERJEE; Fiscal Year: 2010
  2. A Radical Enzyme and its Escorts
    Ruma Banerjee; Fiscal Year: 2007
  3. A Radical Enzyme and its Escorts
    RUMA V BANERJEE; Fiscal Year: 2010
  4. COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIOR
    Kathleen Kantak; Fiscal Year: 2009
  5. Antidepressant Augmentation of Late Life Schizophrenia
    John Kasckow; Fiscal Year: 2005
  6. Strategies for Enhancing Extinction of Drug-Seeking Behavior
    Kathleen M Kantak; Fiscal Year: 2010
  7. COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIOR
    Kathleen M Kantak; Fiscal Year: 2010
  8. COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIOR
    Kathleen Kantak; Fiscal Year: 2007
  9. Strategies for Enhancing Extinction of Drug-Seeking Behavior
    Kathleen Kantak; Fiscal Year: 2009
  10. Strategies for Enhancing Extinction of Drug-Seeking Behavior
    Kathleen Kantak; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications98

  1. ncbi Atypical methylmalonic aciduria: frequency of mutations in the methylmalonyl CoA epimerase gene (MCEE)
    Abigail B Gradinger
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Hum Mutat 28:1045. 2007
    ..mutase (MCM) (mut complementation group) and from defects in the synthesis of the MCM cofactor adenosylcobalamin (cblA, cblB, cblC, cblD, and cblF groups)...
  2. ncbi Disproportionate distribution of Burkholderia cepacia complex species and transmissibility markers in cystic fibrosis
    J J LiPuma
    Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan 48109 0646, USA
    Am J Respir Crit Care Med 164:92-6. 2001
    ..cepacia epidemic strain marker [BCESM] and cable pilin subunit gene [cblA]). Fifty percent of patients were infected with B. cepacia complex genomovar III, 38% with B...
  3. pmc Complementation studies in the cblA class of inborn error of cobalamin metabolism: evidence for interallelic complementation and for a new complementation class (cblH)
    D Watkins
    Division of Medical Genetics, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    J Med Genet 37:510-3. 2000
    To investigate genetic heterogeneity within the cblA class of inborn error of cobalamin metabolism.
  4. ncbi Short-column liquid chromatography with hydride generation atomic fluorescence detection for the speciation of arsenic
    X C Le
    Department of Public Health Sciences, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Anal Chem 70:1926-33. 1998
    ..of speciating nanogram-per-milliliter levels of arsenite (As(III)), arsenate (As(V)), monomethylarsonic acid (MMAA), and dimethylarsinic acid (DMAA) within 3 min...
  5. doi Prediction of outcome in isolated methylmalonic acidurias: combined use of clinical and biochemical parameters
    F Horster
    Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children s Hospital Heidelberg, Im Neuenheimer Feld 430, D 69120, Heidelberg, Germany
    J Inherit Metab Dis 32:630-9. 2009
    ..age at diagnosis, birth decade, diagnostic work-up, cobalamin responsiveness, enzymatic subgroup (mut(0), mut(-), cblA, cblB) and different aspects of long-term outcome. Results 273 patients were included...
  6. ncbi Sensitive method for the determination of roxarsone using solid-phase microextraction with multi-detector gas chromatography
    Aaron R Roerdink
    Department of Chemistry, University of Wisconsin Milwaukee, Milwaukee, WI 53211 3029, USA
    J Chromatogr A 1057:177-83. 2004
    ..of molecular MS for the determination of roxarsone, dimethylarsenic acid (DMAA), and monomethylarsonic acid (MMAA) in complex matrices. Analytes were derivatized based on the approach we previously reported [B. Szostek, J.H...
  7. ncbi Bioaccessibility and excretion of arsenic in Niu Huang Jie Du Pian pills
    Iris Koch
    Environmental Sciences Group, PO Box 17000 Station Forces, Royal Military College of Canada, Kingston, Ontario, Canada K7K 7B4
    Toxicol Appl Pharmacol 222:357-64. 2007
    ..The species of arsenic that were solubilized were inorganic arsenate (As(V)) and arsenite (As(III)) but DMAA and MMAA were detected in urine...
  8. pmc Treatment of subsyndromal depressive symptoms in middle-aged and older adults with schizophrenia: effect on functioning
    John Kasckow
    VA Pittsburgh Health Care System MIRECC and Behavioral Health Service, 7180 Highland Dr, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 25:183-90. 2010
    ..We hypothesized that treating this population with the SSRI citalopram would lead to improvements in social, mental and physical functioning as well as improvements in medication management and quality of life...
  9. ncbi Acquired and inherited disorders of cobalamin and folate in children
    V Michael Whitehead
    The Hematology Service, Montreal Children s Hospital and the McGill University Montreal Children s Hospital Research Institute of the McGill University Health Center, Montreal, QC, Canada
    Br J Haematol 134:125-36. 2006
    ..transcobalamin deficiency) as well as its intracellular metabolism affecting adenosylcobalamin synthesis (cblA and cblB), methionine synthase function (cblE and cblG) or both (cblC, cblD and cblF)...
  10. ncbi Speciation of five arsenic species (arsenite, arsenate, MMAAV, DMAAV and AsBet) in different kind of water by HPLC-ICP-MS
    Sébastien N Ronkart
    Gembloux Agricultural University, Unité de chimie analytique et Phytopharmacie, Passage des Deportes, 2, B 5030 Gembloux, Belgium
    Chemosphere 66:738-45. 2007
    ..has been developed to accurately determine arsenite (As(III)), arsenate (As(V)), mono-methylarsonic acid (MMAA(V)), dimethylarsinic acid (DMAA(V)) and arsenobetaine (AsBet) in different water matrices...
  11. pmc Revised approach for identification of isolates within the Burkholderia cepacia complex and description of clinical isolates not assigned to any of the known genomovars
    Jane F Turton
    Laboratory of HealthCare Associated Infection, Centre for Infections, Health Protection Agency, 61 Colindale Ave, London NW9 5EQ, United Kingdom
    J Clin Microbiol 45:3105-8. 2007
    ..the Burkholderia cepacia complex (Bcc) were identified using a modified strategy that involved PCR detection of the cblA gene for the ET12 lineage simultaneously with detection of the Bcc recA PCR product; recA sequence cluster analysis ..
  12. ncbi Medication management ability assessment: results from a performance-based measure in older outpatients with schizophrenia
    Thomas L Patterson
    Department of Psychiatry, University of California, San Diego, CA 92093 0680, USA
    J Clin Psychopharmacol 22:11-9. 2002
    ..we describe a performance-based measure of medication management, the Medication Management Ability Assessment (MMAA), which represents a modification of the Medication Management Test used in individuals with HIV infection...
  13. ncbi Dissociable effects of lidocaine inactivation of the rostral and caudal basolateral amygdala on the maintenance and reinstatement of cocaine-seeking behavior in rats
    Kathleen M Kantak
    Laboratory of Behavioral Neuroscience and Cognitive Neurobiology Laboratory, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 22:1126-36. 2002
    ..reversible lidocaine-induced inactivation of rostral basolateral amygdala (rBLA) and caudal basolateral amygdala (cBLA) regions on the maintenance and reinstatement of drug-seeking behavior in rats trained to self-administer 1 mg/kg ..
  14. ncbi Arsenic toxicity and accumulation in radish as affected by arsenic chemical speciation
    A A Carbonell-Barrachina
    Departamento de Tecnología Agro Alimentaria, Universidad Miguel Hernandez, Alicante, Espana, Spain
    J Environ Sci Health B 34:661-79. 1999
    ..A 4 x 3 factorial experiment was conducted with treatments consisting of four As chemical forms [As(III), As(V), MMAA, DMAA] and three As concentrations (1.0, 2.0, and 5.0 mg As L-1)...
  15. ncbi Prenatal diagnosis for methylmalonic acidemia and inborn errors of vitamin B12 metabolism and transport
    Chantal F Morel
    Department of Human Genetics, McGill University, Montreal, Que, Canada
    Mol Genet Metab 86:160-71. 2005
    ..rare inborn errors of cobalamin metabolism are known and are distinguished by complementation analysis (mut, cblA-cblH). From 1984 to 2005, we have performed prenatal diagnosis for 117 high-risk pregnancies...
  16. ncbi Renal transplantation in a 14-year-old girl with vitamin B12-responsive cblA-type methylmalonic acidaemia
    D Coman
    Department of Metabolic Medicine, The Royal Children s Hospital, Brisbane, Australia
    Pediatr Nephrol 21:270-3. 2006
    ..Our patient was diagnosed with B(12)-responsive MMA (subsequently proven to be cblA-type MMA) in the postoperative period following renal transplantation for idiopathic chronic renal failure...
  17. pmc Arsenic speciation of solvent-extracted leachate from new and weathered CCA-treated wood
    Bernine I Khan
    Department of Civil, Architectural, and Environmental Engineering, University of Miami, P O Box 248294, Coral Gables, Florida 33124 0630, USA
    Environ Sci Technol 38:4527-34. 2004
    ..leachates were analyzed for inorganic As(III) and As(V) and the organoarsenic species, monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA), using high-performance liquid chromatography followed by hydride generation and ..
  18. pmc Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium
    Teresa A Urban
    Department of Microbiology, University of Virginia Health Sciences, Charlottesville, Virginia, USA
    Infect Immun 73:5426-37. 2005
    ..Isogenic mutants lacking expression of either Cbl pili (cblA or cblS mutants) or the adhesin (adhA mutant) were constructed to assess the individual role of Cbl pili and the ..
  19. ncbi Cognitive predictors of medication adherence among middle-aged and older outpatients with schizophrenia
    Shafali D Jeste
    Children s Hospital Boston, Boston, MA 02115, USA
    Schizophr Res 63:49-58. 2003
    ..we evaluated the correlation of patients' scores on Mattis' Dementia Rating Scale (DRS; total and subscale scores) with scores on the Medication Management Ability Assessment (MMAA), a performance-based measure of medication management.
  20. ncbi Burkholderia respiratory tract infections in Italian patients with cystic fibrosis: molecular characterization
    T Allice
    Department of Clinical and Biological Sciences, University of Torino at S Luigi Gonzaga Hospital, 10043 Orbassano, Torino, Italy
    J Infect 53:159-65. 2006
    ..and adults), to assign the Burkholderia cepacia complex (Bcc) isolates to a genomovar and to assess the presence of cblA and esmR genes in bacteria...
  21. doi Biosafety and colonization of Burkholderia multivorans WS-FJ9 and its growth-promoting effects on poplars
    Guan Xi Li
    College of Forest Resources and Environment, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China
    Appl Microbiol Biotechnol 97:10489-98. 2013
    ..multivorans WS-FJ9 strain did not possess the BCESM and cblA virulence genes. Scanning electron microscopy revealed that the colonization of the WS-FJ9 strain reached 1...
  22. ncbi Effects of SCH-23390 infused into the amygdala or adjacent cortex and basal ganglia on cocaine seeking and self-administration in rats
    Andrea T Alleweireldt
    Department of Psychology, Arizona State University, Tempe, 85287, USA
    Neuropsychopharmacology 31:363-74. 2006
    ..we infused the D1 antagonist, SCH-23390, into the rostral basolateral amygdala (rBLA), caudal basolateral amygdala (cBLA), or central amygdala (CEA), and tested its effects on self-administration of cocaine, as well as reinstatement of ..
  23. ncbi Lack of cable pili expression by cblA-containing Burkholderia cepacia complex
    Umadevi Sajjan
    Department of Structural Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    Microbiology 148:3477-84. 2002
    ..III strain that predominates among CF patients in Canada and the United Kingdom and is characterized by distinctive cblA-encoded pili that have a cable-like morphology. In a previous survey of B...
  24. pmc Biochemical-genetic analysis and distribution of DES-1, an Ambler class A extended-spectrum beta-lactamase from Desulfovibrio desulfuricans
    Anne Sophie Morin
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 46:3215-22. 2002
    ..It was weakly related to class A beta-lactamases CblA, CepA, CfxA, and CfxA2 from other anaerobic species, Bacteroides spp. and Prevotella intermedia...
  25. doi Pregnancy in a methylmalonic acidemia patient with kidney transplantation: a case report
    R Lubrano
    Dipartimento di Pediatria, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Am J Transplant 13:1918-22. 2013
    ..We report on a case of pregnancy in a patient 29-year-old with methylmalonic acidemia cblA type (OMIM 251100) who received a renal transplantation at the age of 17 for end-stage renal disease (ESRD) caused ..
  26. doi High resolution melting analysis of the MMAA gene in patients with cblA and in those with undiagnosed methylmalonic aciduria
    Laura Dempsey-Nunez
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Mol Genet Metab 107:363-7. 2012
    The gene product of MMAA is required for the intracellular metabolism of cobalamin (Cbl). Mutations in this gene lead to the cblA class of disorders, characterized by isolated methylmalonic aciduria...
  27. doi Renal dysfunction in methylmalonic acidurias: review for the pediatric nephrologist
    Marina A Morath
    Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children s Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany
    Pediatr Nephrol 28:227-35. 2013
    ..The majority of these patients, especially those having mut°, cblB, and cblA deficiency, are at increased risk of developing chronic kidney disease secondary to tubulointerstitial nephritis to ..
  28. doi Clinical and molecular findings in Thai patients with isolated methylmalonic acidemia
    Nithiwat Vatanavicharn
    Division of Medical Genetics, Department of Pediatrics, Mahidol University, Bangkok, Thailand
    Mol Genet Metab 106:424-9. 2012
    ..788G>T (p.G263V), c.809_812dupGGGC (p.D272Gfs*2), and c.1426C>T (p.Q476*); one mutation in the MMAA gene: c.292A>G (p.R98G); and three mutations in the MMAB gene: c.682delG (p.A228Pfs*2), c.435delC (p...
  29. ncbi Sexual and reproductive health education among dressmakers and hairdressers in the Assin South District of Ghana
    Samuel A Owusu
    University of Cape Coast, Ghana
    Afr J Reprod Health 15:109-19. 2011
    ..some of the respondents were able to mention some sexual and reproductive health education programmes such as 'Mmaa Nkomo', most of them could not recall the recent topic discussed...
  30. doi Antibiotic resistance gene profiling of faecal and oral anaerobes collected during an antibiotic challenge trial
    M Kirchner
    Department of Bacteriology and Food Safety, Animal Health and Veterinary Laboratories Agency, Addlestone, Surrey KT15 3NB, UK
    Anaerobe 23:20-2. 2013
    ..The results demonstrated that genes normally associated with anaerobes were most prevalent such as tetQ, cepA and cblA although several genes associated with Enterobacteriaceae including sul2, blaSHV and strB were also detected.
  31. pmc Burkholderia cepacia complex bacteria from clinical and environmental sources in Italy: genomovar status and distribution of traits related to virulence and transmissibility
    Annamaria Bevivino
    Biotechnology and Agriculture Division, ENEA C R Casaccia, 00060 S Maria di Galeria, Rome, Italy
    J Clin Microbiol 40:846-51. 2002
    ..hemolytic activities, and transmissibility, in which transmissibility is determined by detection of the esmR and cblA genes. Among the clinical isolates, B...
  32. ncbi Adherence and autoaggregation phenotypes of a Burkholderia cenocepacia cable pilus mutant
    Mladen Tomich
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455 0312, USA
    FEMS Microbiol Lett 228:287-97. 2003
    ..The cblA gene, encoding the major pilin subunit, was insertionally inactivated, and the resulting mutant was shown to be ..
  33. ncbi High prevalence of cfxA beta-lactamase in aminopenicillin-resistant Prevotella strains isolated from periodontal pockets
    T Fosse
    Laboratoire de Bacteriologie, Hôpital L Archet 2, Centre Hospitalier Universitaire de Nice, Nice, France
    Oral Microbiol Immunol 17:85-8. 2002
    ..33/35 strains). PCR assays were used to detect cfxA and cepA/cblA, the genes encoding class A/group2e beta-lactamases previously described in the Bacteroides fragilis group...
  34. pmc Six-year molecular analysis of Burkholderia cepacia complex isolates among cystic fibrosis patients at a referral center for lung transplantation
    David G Heath
    Clinical Microbiology Immunology Laboratories, University of North Carolina Hospitals, Chapel Hill 27514, USA
    J Clin Microbiol 40:1188-93. 2002
    ..characterized by pulsed-field gel electrophoresis (PFGE) and were assayed by PCR to detect the cable pilin gene, cblA. PFGE results indicated that six separate clusters (clusters A to F) were present among the 56 isolates and that ..
  35. doi Leukoencephalopathies associated with disorders of cobalamin and folate metabolism
    Bridget Wilcken
    Discipline of Paediatrics, University of Sydney, Sydney, Australia
    Semin Neurol 32:68-74. 2012
    ..Mutations at various metabolic steps affect the synthesis of adenosylcobalamin (CblA, CblB, and CblD2), methylcobalamin (CblE, CblG, and CblD1), or both of these (CblF, CblD, and CblC)...
  36. ncbi Influence of EDTA and chemical species on arsenic accumulation in Spirodela polyrhiza L. (duckweed)
    M Azizur Rahman
    Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920 1192, Japan
    Ecotoxicol Environ Saf 70:311-8. 2008
    ..05) higher than those of organic species (monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA))...
  37. ncbi Burkholderia cepacia complex infection in a cohort of Italian patients with cystic fibrosis
    Antonietta Lambiase
    Department of Biology and Pathology, Luigi Califano, University of Naples Federico II, Italy
    J Microbiol 45:275-9. 2007
    ..Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive...
  38. doi Diagnostic work-up and management of patients with isolated methylmalonic acidurias in European metabolic centres
    T Zwickler
    Division of Metabolic Diseases, University Children s Hospital, Heidelberg, Germany
    J Inherit Metab Dis 31:361-7. 2008
    ..80%) returned questionnaires on 183 patients: 89 of the patients were classified as mut(0), 36 as mut(-), 13 as cblA, 7 as cblB, and 38 as cblA/B...
  39. ncbi Long-term outcome in methylmalonic acidurias is influenced by the underlying defect (mut0, mut-, cblA, cblB)
    Friederike Hörster
    Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children s Hospital, D 69120 Heidelberg, Germany
    Pediatr Res 62:225-30. 2007
    ..mutase (MCM) (mut0, mut-) or deficient synthesis of its cofactor 5'-deoxyadenosylcobalamin (AdoCbl) (cblA, cblB). The aim of this study was to compare the long-term outcome in patients from these four enzymatic subgroups...
  40. ncbi Predictors of medication competence in schizophrenia patients
    R Walter Heinrichs
    Department of Psychology, York University, 4700 Keele Street, Toronto, Ontario, Canada
    Psychiatry Res 157:47-52. 2008
    ..Competence in medication management was indexed with the Medication Management Ability Assessment (MMAA)...
  41. ncbi Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria
    Paul A Hubbard
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 282:31308-16. 2007
    ..Impairments in the human homologue of MeaB, MMAA, lead to methylmalonic aciduria, an inborn error of metabolism...
  42. ncbi Methylmalonic acidaemia: examination of genotype and biochemical data in 32 patients belonging to mut, cblA or cblB complementation group
    B Merinero
    Centro de Diagnóstico de Enfermedades Moleculares, Centro de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma, CIBER de Enfermedades Raras, Madrid, Spain
    J Inherit Metab Dis 31:55-66. 2008
    ..A new sequence variation (c.562G>C) in the MMAA gene was identified. Most of the cblA patients carried premature termination codons (PTC) in both alleles...
  43. doi Causes of and diagnostic approach to methylmalonic acidurias
    B Fowler
    Metabolic Unit, University Children s Hospital, Roemergasse 8, Basel, CH 4058, Switzerland
    J Inherit Metab Dis 31:350-60. 2008
    ..The cblA, cblB and the variant 2 form of cblD complementation groups are linked to processes unique to Ado-Cbl synthesis...
  44. pmc Assessment of medication management ability in middle-aged and older adults with bipolar disorder
    Colin A Depp
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Clin Psychopharmacol 28:225-9. 2008
    ..performance-based measure of medication management ability, the Medication Management Ability Assessment (MMAA), we compared performance of 29 middle-aged older community-dwelling outpatients with BD who were clinically stable ..
  45. doi A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling
    Judith Langenick
    University of Dundee, School of Life Sciences, Dow Street, Dundee DD1 5EH, UK
    J Cell Sci 121:3524-30. 2008
    ..b>CblA, a Dictyostelium homologue of the Cbl proteins, contains all three conserved domains...
  46. pmc Enamel defects and salivary methylmalonate in methylmalonic acidemia
    C W Bassim
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 1851, USA
    Oral Dis 15:196-205. 2009
    ..To characterize enamel defects in patients with methylmalonic acidemia (MMA) and cobalamin (cbl) metabolic disorders and to examine salivary methylmalonate levels in MMA...
  47. doi Effect of eutrophication on the distribution of arsenic species in eutrophic and mesotrophic lakes
    H Hasegawa
    Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920 1192, Japan
    Sci Total Environ 407:1418-25. 2009
    ..Most of methylarsenic fraction was dimethylarsinic acid (DMAA), and the concentration of monomethylarsonic acid (MMAA) was below the detection limit...
  48. doi Organic solvent-free reversed-phase ion-pairing liquid chromatography coupled to atomic fluorescence spectrometry for organoarsenic species determination in several matrices
    Romina P Monasterio
    Analytical Chemistry Research and Development Group QUIANID, LISAMEN CCT CONICET Mendoza, Mendoza, Argentina
    J Agric Food Chem 59:3566-74. 2011
    ..and nitarsone (NIT), as well as other organic As species (dimethylarsonic acid (DMAA) and monomethylarsonic acid (MMAA)) by ion-pairing high-performance liquid chromatography coupled to hydride generation atomic fluorescence ..
  49. doi Inborn errors of cobalamin absorption and metabolism
    David Watkins
    Department of Human Genetics, McGill University, Canada
    Am J Med Genet C Semin Med Genet 157:33-44. 2011
    ..A series of inborn errors of intracellular cobalamin metabolism, designated cblA-cblG, have been differentiated by complementation analysis...
  50. doi Field fluxes and speciation of arsines emanating from soils
    Adrien Mestrot
    Institute of Biological and Environmental Sciences, University of Aberdeen, Cruickshank Building, St Machar Drive, Aberdeen AB24 3UU, United Kingdom
    Environ Sci Technol 45:1798-804. 2011
    ..Addition of methylated oxidated pentavalent As, namely monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA), to soil resulted in elevated yearly rates of volatilization with up to 3...
  51. pmc Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation
    D Sean Froese
    Structural Genomics Consortium, University of Oxford OX3 7DU, United Kingdom
    J Biol Chem 285:38204-13. 2010
    ..One of the processing proteins, MMAA (methylmalonic aciduria type A), is implicated in the mitochondrial assembly of AdoCbl into MUT and is defective in ..
  52. doi Different altered pattern expression of genes related to apoptosis in isolated methylmalonic aciduria cblB type and combined with homocystinuria cblC type
    Ana Jorge-Finnigan
    Centro de Diagnóstico de Enfermedades Moleculares, Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Departamento de Biologia Molecular, Universidad Autonoma de Madrid, Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER Madrid, Spain
    Biochim Biophys Acta 1802:959-67. 2010
    ..of p38 and JNK kinases in stress-response, their activation in fibroblasts from a spectrum of patients (mut, cblA, cblB, cblC and cblE) was analyzed revealing an increased expression of the phosphorylated-forms, specially in cblB ..
  53. doi Heat-assisted aqueous extraction of rice flour for arsenic speciation analysis
    Tomohiro Narukawa
    National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    J Agric Food Chem 58:8183-8. 2010
    ..Arsenite [As(III)], arsenate [As(V)], monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA) were detected in NIST SRM, and As(III), As(V) and DMAA were found in NMIJ CRM and ..
  54. doi The molecular landscape of propionic acidemia and methylmalonic aciduria in Latin America
    Belen Perez
    Centro de Diagnóstico de Enfermedades Moleculares, Centro de Biología Molecular SO UAM CSIC, Universidad Autonoma de Madrid, Campus de Cantoblanco, Madrid, Spain
    J Inherit Metab Dis 33:S307-14. 2010
    ..cblB and cblC patients presented the symptoms early and in general had more neurological complications, while cblA and mut(-) patients exhibited a late-onset presentation, and in general the long-term outcome was better...
  55. pmc Functional significance of preserved affect recognition in schizophrenia
    Joanna M Fiszdon
    Yale University, Department of Psychiatry, New Haven, CT, USA
    Psychiatry Res 176:120-5. 2010
    ..Skill Assessment (UPSA), Social Skills Performance Assessment (SSPA), Medication Management Ability Assessment (MMAA)] and interviewer-rated [Quality of Life Scale (QLS), Independent Living Skills Survey (ILSS)] measures of ..
  56. doi Long-term outcome in methylmalonic aciduria: a series of 30 French patients
    M A Cosson
    Metabolic Center, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Mol Genet Metab 97:172-8. 2009
    ..To better delineate the natural history of patients with methylmalonic aciduria (MMA)...
  57. doi Spondylocostal dysostosis associated with methylmalonic aciduria
    Rachel S Honjo
    Instituto da Criança, University of Sao Paulo, Sao Paulo, Brazil
    Genet Test Mol Biomarkers 13:181-3. 2009
    ..Here we report on a case of a Brazilian boy with both diseases. As we know, it is the first case in the literature with the occurrence of both SCD and MMA--the first a skeletal disease and the latter an inborn error of metabolism...
  58. doi Protection and reactivation of human methylmalonyl-CoA mutase by MMAA protein
    Tóshiko Takahashi-Íñiguez
    Departamento de Biologia Molecular y Biotecnologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico, DF 04510, Mexico
    Biochem Biophys Res Commun 404:443-7. 2011
    ..In this study, we examined the influence of human MMAA protein on the kinetics of the reaction catalyzed by methylmalonyl-CoA mutase (MCM) by testing both purified ..
  59. doi Multiple OXPHOS deficiency in the liver of a patient with CblA methylmalonic aciduria sensitive to vitamin B(12)
    V Valayannopoulos
    Reference Center for Inherited Metabolic Disorders, Hôpital Necker Enfants Malades and Université Paris Descartes, 149 rue de Sevres, 75743, Paris Cedex 15, France
    J Inherit Metab Dis 32:159-62. 2009
    An adult patient with methylmalonic aciduria due to defective cobalamin synthesis (CblA) responsive to vitamin B(12) presented suddenly with severe visual impairment ascribed to optic atrophy followed by a fatal multiorgan failure and ..
  60. doi Diversity analysis of Burkholderia cepacia complex in the water bodies of West Lake, Hangzhou, China
    Yuan Fang
    State Key Laboratory of Rice Biology and Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Ministry of Agriculture, Institute of Biotechnology, Zhejiang University, Hangzhou 310029, P R China
    J Microbiol 49:309-14. 2011
    ..In addition, all Bcc isolates tested were PCR negative for the cblA and esmR transmissibility marker genes except B. cenocepacia IIIB A8 which was positive for esmR genelater...
  61. ncbi Arsenic accumulation in bark beetles and forest birds occupying mountain pine beetle infested stands treated with monosodium methanearsonate
    Christy A Morrissey
    Environment Canada, Canadian Wildlife Service, Pacific Wildlife Research Centre, 5421 Robertson Road, Delta, British Columbia, Canada
    Environ Sci Technol 41:1494-500. 2007
    ..3-700.2 microg g(-1) dw (geometric mean 42.0 microg g(-1)) with the metabolite monomethyl arsonic acid (MMAA) contributing 90-97% to the total arsenic extracted...
  62. ncbi Hydrous ferric oxide incorporated diatomite for remediation of arsenic contaminated groundwater
    Min Jang
    Department of Civil and Environmental Engineering, University of Wisconsin Madison, 1415 Engineering Drive, Madison, Wisconsin 53706, USA
    Environ Sci Technol 41:3322-8. 2007
    ..1%) and monomethyl arsenic acid (MMAA, 22.7%), while dimethyl arsenic acid (DMAA) and arsenate were only 2.4 and 1.3%, respectively...
  63. ncbi Epidemiology of Burkholderia cepacia complex species recovered from cystic fibrosis patients: issues related to patient segregation
    Andrew McDowell
    Department of Bacteriology, Northern Ireland Public Health Laboratory, Belfast, UK
    J Med Microbiol 53:663-8. 2004
    ..cepacia complex species and putative transmissibility markers [cable pilin subunit gene (cblA) and the B. cepacia epidemic strain marker (BCESM)]...
  64. ncbi MeaB is a component of the methylmalonyl-CoA mutase complex required for protection of the enzyme from inactivation
    Natalia Korotkova
    Departments of Chemical Engineering and Microbiology, University of Washington, Seattle, Washington 98195 1750, USA
    J Biol Chem 279:13652-8. 2004
    ..Recently, a human gene of unknown function, MMAA, has been implicated in methylmalonic aciduria (Dobson, C. M., Wai, T., Leclerc, D., Wilson, A., Wu, X., Dore, C...
  65. pmc Molecular typing of, and distribution of genetic markers among, Burkholderia cepacia complex isolates from Brazil
    Maria G Detsika
    Department of Medical Microbiology and Genitourinary Medicine, University of Liverpool, Liverpool L69 3GA, United Kingdom
    J Clin Microbiol 41:4148-53. 2003
    ..PCR screening indicated the presence of cblA in only two isolates, whereas the B. cepacia epidemic strain marker was found in 22 of 28 genomovar IIIA isolates...
  66. ncbi Identification and molecular analysis of cable pilus biosynthesis genes in Burkholderia cepacia
    Umadevi S Sajjan
    Division of Structural Biology and Biochemistry, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Microbiology 149:961-71. 2003
    ..The cblA gene, encoding the major pilin subunit, is often used as a DNA marker to identify potentially virulent isolates...
  67. pmc Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements
    C Melissa Dobson
    Department of Biochemistry and Molecular Biology, University of Calgary, AB, Canada T2N 1N4
    Proc Natl Acad Sci U S A 99:15554-9. 2002
    ..These data confirm that the identified gene, MMAA, corresponds to the cblA complementation group. It is located on chromosome 4q31...
  68. pmc Patterns of epithelial cell invasion by different species of the Burkholderia cepacia complex in well-differentiated human airway epithelia
    Ute Schwab
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599 7248, USA
    Infect Immun 70:4547-55. 2002
    ..cepacia complex, including a strain from the ET12 lineage (BC-7, genomovar III, cblA(+)), which is associated with most cepacia syndrome fatalities among CF populations, a genomovar IV strain (HI2258),..
  69. ncbi Interaction of cblA/adhesin-positive Burkholderia cepacia with squamous epithelium
    Umadevi Sajjan
    Departments of Structural Biology and Biochemistry, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cell Microbiol 4:73-86. 2002
    ..strain of Burkholderia cepacia from genomovar III carries the cable pilin gene, expresses the 22 kDa adhesin (cblA +ve/Adh +ve), binds to cytokeratin 13 (CK13) and is invasive...
  70. ncbi Role of microbes in controlling the speciation of arsenic and production of arsines in contaminated soils
    Riina Turpeinen
    Department of Ecological and Environmental Sciences, University of Helsinki, Lahti, Finland
    Sci Total Environ 285:133-45. 2002
    ..arsenate [As(V)], under both aerobic and anaerobic conditions to arsenite [As(III)], monomethylarsonic acid [MMAA], dimethylarsinic acid [DMAA] and to volatile trimethylarsine [TMA] was, however, less than 0...
  71. ncbi Cognitive task performance after lidocaine-induced inactivation of different sites within the basolateral amygdala and dorsal striatum
    K M Kantak
    Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Massachusetts 02215, USA
    Behav Neurosci 115:589-601. 2001
    ..CCP) and win-stay accuracy were examined after lidocaine inactivation of either the rostral (rBLA) or caudal (cBLA) basolateral amygdala, the lateral (lDST) or medial (mDST) dorsal striatum, or a control site in rats...
  72. ncbi Arsenic metabolism in seaweed-eating sheep from Northern Scotland
    J Feldmann
    University of Aberdeen, Department of Chemistry, Scotland, UK
    Fresenius J Anal Chem 368:116-21. 2000
    ..different arsenic species in body fluids (arsenite, arsenate, dimethylarsinic acid (DMAA), monomethylarsonic acid (MMAA), trimethylarsine oxide (TMAO), tetramethylarsonium ion (TMA), arsenobetaine (AsB), arsenocholine (AsC), ..
  73. ncbi Leaching, runoff and speciation of arsenic in a laboratory mesocosm
    M Ruokolainen
    Department of Ecological and Environmental Sciences, University of Helsinki, Lahti, Finland
    Sci Total Environ 258:139-47. 2000
    ..The different arsenic species; arsenite [As(III)], arsenate [As(V)], monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA), were analysed from irrigation and discharge water; mesocosm pool water; and ..
  74. ncbi Arsenic toxicity and accumulation in turnip as affected by arsenic chemical speciation
    A A Carbonell-Barrachina
    Departamento de Tecnología Agro Alimentaria, Universidad Miguel Hernandez, Alicante, Spain
    J Agric Food Chem 47:2288-94. 1999
    ..A 4 x 3 factorial experiment was conducted with four As species [arsenite, arsenate, methylarsonic acid (MMAA), dimethylarsinic acid (DMAA)] and three As concentrations (1.0, 2.0, and 5.0 mg L(-)(1))...
  75. pmc TLA-1: a new plasmid-mediated extended-spectrum beta-lactamase from Escherichia coli
    J Silva
    Departamento de Resistencia Bacteriana, Instituto Nacional de Salud Publica, Centro de Investigaciones sobre Enfermedades Infecciosas, Cuernavaca, Morelos, Mexico
    Antimicrob Agents Chemother 44:997-1003. 2000
    ..8% identity with the VEB-1 class A beta-lactamase from E. coli; 40 to 42% identity with CblA of Bacteroides uniformis, PER-1 of Pseudomonas aeruginosa, and PER-2 of Salmonella typhimurium; and 39% identity ..
  76. ncbi A third human CBL gene is on chromosome 19
    V Ollendorff
    U 119 INSERM, 27 Bd Lei Roure, 13009 Marseille, France
    Int J Oncol 13:1159-61. 1998
    ..we isolated a cosmid containing part of a new CBL gene, CBLc, related to the two characterized paralogous genes CBLa and CBLb...
  77. pmc Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes
    M C Garin
    Clinical Diabetes Unit, Division of Endocrinology and Diabetes, University Hospital, Geneva, Switzerland
    J Clin Invest 99:62-6. 1997
    ..in plasma concentrations and activities of paraoxonase between genotypes defined by the 54 polymorphism: MMAA, MLAA, LLAA; protein, 65.3+/-18.0, 77.9+/-18.0, 93.5+/-26.0 microg/ml; P < 0.0001: activity (phenylacetate), 48...
  78. pmc Identification of IS1356, a new insertion sequence, and its association with IS402 in epidemic strains of Burkholderia cepacia infecting cystic fibrosis patients
    S D Tyler
    Bureau of Microbiology, Laboratory Centre for Disease Control, Ottawa, Ontario, Canada
    J Clin Microbiol 34:1610-6. 1996
    ..was any association between the presence of various insertion sequence (IS) elements, the cable pilin subunit gene (cblA), electrophoretic type (ET), and ribotype (RT) in a collection of 97 clinical and 2 environmental isolates of B...
  79. ncbi Mutation analysis of the MMAA and MMAB genes in Japanese patients with vitamin B(12)-responsive methylmalonic acidemia: identification of a prevalent MMAA mutation
    Xue Yang
    Department of Medical Genetics, Tohoku University School of Medicine, Japan
    Mol Genet Metab 82:329-33. 2004
    ..Recently, the genes responsible for cblA and cblB were identified as MMAA and MMAB, respectively...
  80. pmc Structurally variant classes of pilus appendage fibers coexpressed from Burkholderia (Pseudomonas) cepacia
    R Goldstein
    Section of Molecular Genetics, Maxwell Finland Laboratory for Infectious Diseases, Boston University School of Medicine, Massachusetts
    J Bacteriol 177:1039-52. 1995
    ..B. cepacia-encoded cblA pilin gene hybridization-based analysis revealed that one associated class, cable (Cbl) adhesin type IIB...
  81. ncbi Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis
    Trude Handal
    Department of Oral Biology, Dental Faculty, University of Oslo, 0316 Oslo, Norway
    FEMS Microbiol Lett 242:319-24. 2005
    ..and USA were screened for the presence of the bla(TEM), bla(SHV), bla(OXA), bla(ampC), bla(cfxA), and bla(cepA/cblA) genes by the polymerase chain reaction (PCR)...
  82. ncbi Pilus-mediated epithelial cell death in response to infection with Burkholderia cenocepacia
    K John Cheung
    Division of Infectious Diseases, Immunology and Rheumatology, Children s Hospital and Regional Medical Center, 307 Westlake Avenue N, Seattle, WA 98109, USA
    Microbes Infect 9:829-37. 2007
    ..However, the frequency of cell death was lower in cells infected with a non-piliated mutant, K56-2 cblA::Tp...
  83. pmc Suicidality in middle aged and older patients with schizophrenia and depressive symptoms: relationship to functioning and Quality of Life
    J Kasckow
    VA Pittsburgh Health Care System, Pittsburgh, PA 15206, USA
    Int J Geriatr Psychiatry 22:1223-8. 2007
    ....
  84. ncbi Burkholderia cenocepacia, B. multivorans, B. ambifaria and B. vietnamiensis isolates from cystic fibrosis patients have different profiles of exoenzyme production
    Grasiella Maria Carvalho Ventura
    Departamento de Microbiologia e Imunologia, Faculdade de Ciencias Medicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    APMIS 115:311-8. 2007
    ..None of the isolates exhibited the genetic markers cblA and BCESM, assessed by polymerase chain reaction...
  85. ncbi Mutation and biochemical analysis of 19 probands with mut0 and 13 with mut- methylmalonic aciduria: identification of seven novel mutations
    Thomas J Lempp
    Division of Metabolism and Molecular Pediatrics, University Children s Hospital Zurich, Switzerland
    Mol Genet Metab 90:284-90. 2007
    ..e. cblA, cblB and cblD-variant 2...
  86. ncbi Mitochondrial vitamin B12-binding proteins in patients with inborn errors of cobalamin metabolism
    E Moras
    Department of Human Genetics, McGill University, Montreal, Que, Canada H3G 1A4
    Mol Genet Metab 90:140-7. 2007
    ..metabolism are autosomal recessive disorders and have been classified into nine distinct complementation classes (cblA-cblH and mut)...
  87. ncbi Assessment of medication management by community-living elderly persons with two standardized assessment tools: a cross-sectional study
    Lisa C Hutchison
    Department of Pharmacy Practice, University of Arkansas for Medical Sciences College of Pharmacy, Little Rock, 72205, USA
    Am J Geriatr Pharmacother 4:144-53. 2006
    ..Assessment tools to determine the ability to manage medication therapy have not been tested in elderly patients with cognitive impairment...
  88. pmc Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism
    Randy J Chandler
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Genet Metab 89:64-73. 2006
    ..carboxylase subunits A and B (pcca-1, pccb-1), methylmalonic acidemia cobalamin A complementation group (mmaa-1), co(I)balamin adenosyltransferase (mmab-1), MMACHC (cblc-1), methylmalonyl-CoA epimerase (mce-1) and ..
  89. ncbi Quantitative analysis of mitochondrial protein expression in methylmalonic acidemia by two-dimensional difference gel electrophoresis
    Eva Richard
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    J Proteome Res 5:1602-10. 2006
    ..forms: mut MMA associated with MCM deficiency, three different defects related to mitochondrial Adocbl formation (cblA, cblB, and cblH), and cblD variant 2...
  90. ncbi A homozygous nonsense mutation in the methylmalonyl-CoA epimerase gene (MCEE) results in mild methylmalonic aciduria
    H Bikker
    Laboratory of Genetic Metabolic Diseases and Department of Clinical Genetics Pediatrics Pediatric Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Hum Mutat 27:640-3. 2006
    ..Both a higher residual activity of methylmalonyl-CoA mutase as well as the vitamin B12-responsive defects (cblA and cblB) may form the basis of the mild disorder...
  91. ncbi Homozygous nonsense mutation in the MCEE gene and siRNA suppression of methylmalonyl-CoA epimerase expression: a novel cause of mild methylmalonic aciduria
    C Melissa Dobson
    Department of Biochemistry and Molecular Biology, University of Calgary, Canada
    Mol Genet Metab 88:327-33. 2006
    ..as belonging to the cblA complementation group of vitamin B12 disorders but lacking mutations in the affected gene, MMAA, was tested for mutations in the MCEE gene...
  92. ncbi Medication nonadherence in older people with serious mental illness: prevalence and correlates
    Sarah I Pratt
    Dartmouth Medical School NH, Dartmouth Psychiatric Research Center, NH 03301, USA
    Psychiatr Rehabil J 29:299-310. 2006
    ..higher adherence was related to better performance on the Medication Management Administration Assessment (MMAA) role-play, which was highly correlated with several domains of cognitive functioning, suggesting that the MMAA may ..
  93. ncbi Energetics of interaction between the G-protein chaperone, MeaB, and B12-dependent methylmalonyl-CoA mutase
    Dominique Padovani
    Redox Biology Center and the Biochemistry Department, University of Nebraska, Lincoln, NE 68588 0664, USA
    J Biol Chem 281:17838-44. 2006
    ..Mutations in the human homolog of MeaB, MMAA, lead to methylmalonic aciduria, an inborn error of metabolism that can be fatal...
  94. ncbi Molecular epidemiology and antibiotic susceptibility of Burkholderia cepacia-complex isolates from an Italian cystic fibrosis centre
    G Golini
    Department of Pathology, Microbiology Section, University of Verona, Strada Le Grazie 8, 37100 Verona, Italy
    Eur J Clin Microbiol Infect Dis 25:175-80. 2006
    ..Strains were examined for species, presence of putative epidemic and virulence markers (i.e., cblA and the B. cepacia epidemic-strain marker [BCESM]), genetic relatedness and antibiotic susceptibility...
  95. ncbi Arsenic speciation analysis in water samples: a review of the hyphenated techniques
    Ewa Terlecka
    Institute of Meteorology and Water Management, ul Parkowa 30, Wroclaw, Poland
    Environ Monit Assess 107:259-84. 2005
    ..In determinations of water samples inorganic arsenate (As(III), As(V)), methylated metabolities (MMAA, DMAA) and other organic forms such as AsB, AsC, arsenosugars or arsenic containing lipids have the most importance...
  96. ncbi Genetic analysis of three genes causing isolated methylmalonic acidemia: identification of 21 novel allelic variants
    María Angeles Martínez
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma, Madrid, Spain
    Mol Genet Metab 84:317-25. 2005
    ..MMA, and classified into three different complementation groups cblA, cblB, and cblH associated with defects in the MMAA and MMAB genes and with an unidentified protein, respectively...
  97. ncbi Inorganic arsenic compounds and methylated metabolites induce morphological transformation in two-stage BALB/c 3T3 cell assay and inhibit metabolic cooperation in V79 cell assay
    Toshiyuki Tsuchiya
    Safety Evaluation Center, Showa Denko K K, Chiba 267 0056, Japan
    Toxicol Sci 84:344-51. 2005
    ..to determine initiating and promoting activities of disodium arsenate, sodium arsenite, monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA)...
  98. ncbi Mutations in the MMAA gene in patients with the cblA disorder of vitamin B12 metabolism
    Jordan P Lerner-Ellis
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Hum Mutat 24:509-16. 2004
    Mutations in the MMAA gene on human chromosome 4q31.21 result in vitamin B12-responsive methylmalonic aciduria (cblA complementation group) due to deficiency in the synthesis of adenosylcobalamin...

Research Grants62

  1. A Radical Enzyme and its Escorts
    RUMA V BANERJEE; Fiscal Year: 2010
    ..With the recent discovery of the genes encoding MMAA, a G- protein chaperone of unknown function, and adenosyltransferase, which synthesizes AdoCbl from cob(ll)alamin, ..
  2. A Radical Enzyme and its Escorts
    Ruma Banerjee; Fiscal Year: 2007
    ..With the recent discovery of the genes encoding MMAA, a G- protein chaperone of unknown function, and adenosyltransferase, which synthesizes AdoCbl from cob(ll)alamin, ..
  3. A Radical Enzyme and its Escorts
    RUMA V BANERJEE; Fiscal Year: 2010
    ..With the recent discovery of the genes encoding MMAA, a G- protein chaperone of unknown function, and adenosyltransferase, which synthesizes AdoCbl from cob(ll)alamin, ..
  4. COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIOR
    Kathleen Kantak; Fiscal Year: 2009
    ....
  5. Antidepressant Augmentation of Late Life Schizophrenia
    John Kasckow; Fiscal Year: 2005
    ....
  6. Strategies for Enhancing Extinction of Drug-Seeking Behavior
    Kathleen M Kantak; Fiscal Year: 2010
    ..This approach is especially relevant for research involving cognitive enhancing drugs, where non-human primates can serve as a key translational interface for the development of pharmacotherapies. ..
  7. COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIOR
    Kathleen M Kantak; Fiscal Year: 2010
    ....
  8. COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIOR
    Kathleen Kantak; Fiscal Year: 2007
    ..abstract_text> ..
  9. Strategies for Enhancing Extinction of Drug-Seeking Behavior
    Kathleen Kantak; Fiscal Year: 2009
    ..This approach is especially relevant for research involving cognitive enhancing drugs, where non-human primates can serve as a key translational interface for the development of pharmacotherapies. ..
  10. Strategies for Enhancing Extinction of Drug-Seeking Behavior
    Kathleen Kantak; Fiscal Year: 2009
    ..This approach is especially relevant for research involving cognitive enhancing drugs, where non-human primates can serve as a key translational interface for the development of pharmacotherapies. ..
  11. COGNITIVE ASPECTS OF ADDICTION-RELATED BEHAVIOR
    Kathleen Kantak; Fiscal Year: 2002
    ..This project may identify the unique cognitive challenges that face a drug-addicted individual ..
  12. Behavior Change and Maintenance Intervention for HIV+ MSM Methamphetamine Users
    Thomas Patterson; Fiscal Year: 2009
    ..g., binge use, injection, polydrug use) and key psychosocial factors (e.g., sexual compulsivity, experiences of abuse) will be explored. ..
  13. Validating Assessments of Real-World Outcome
    Thomas Patterson; Fiscal Year: 2009
    ....
  14. Reducing HIV/STD risk, methamphetamine use, and depression among heterosexuals
    Thomas Patterson; Fiscal Year: 2009
    ....
  15. Safer sex intervention for male clients of female sex workers in Tijuana, Mexico
    Thomas L Patterson; Fiscal Year: 2010
    ....
  16. Validating Assessments of Real-World Outcome
    Thomas L Patterson; Fiscal Year: 2010
    ....
  17. Implementation of an efficacious intervention for High Risk Women in Mexico
    THOMAS L contact PATTERSON; Fiscal Year: 2010
    ....
  18. Technology for DNA Damage Analysis and Biomarkers
    X Le; Fiscal Year: 2004
    ..The technology will also be useful for monitoring DNA damage induced by anticancer agents and for studying DNA repair, which is an essential protection mechanism against cancer initiation. ..
  19. Behavior Change and Maintenance Intervention for HIV+ MSM Methamphetamine Users
    Thomas Patterson; Fiscal Year: 2007
    ..g., binge use,injection, polydrug use) and key psychosocial factors (e.g., sexual compulsivity, experiences of abuse) will be explored. ..
  20. Burkholderia sp: Identification of major clonal lineages
    John LiPuma; Fiscal Year: 2004
    ..mallei and B. pseudomallei. ..
  21. HIV/STD Risk Reduction and Maintenance in At-Risk People
    Thomas Patterson; Fiscal Year: 2005
    ..Subgroup differences in the effectiveness of the intervention based on individual factors (e.g.,ethnicity, gender) and psychosocial factors (e.g., readiness for change) will be explored. ..
  22. A Medication Adherence Intervention for Older Adults with Bipolar Disorder
    Colin Depp; Fiscal Year: 2007
    ....
  23. Reducing HIV/STD risk, methamphetamine use, and depression among heterosexuals
    Thomas Patterson; Fiscal Year: 2007
    ....
  24. Behavior Change and Maintenance Intervention for HIV+ MSM Methamphetamine Users
    Thomas L Patterson; Fiscal Year: 2010
    ..g., binge use, injection, polydrug use) and key psychosocial factors (e.g., sexual compulsivity, experiences of abuse) will be explored. ..