MKS1

Summary

Gene Symbol: MKS1
Description: Meckel syndrome, type 1
Alias: BBS13, MES, MKS, POC12, FABB proteome-like protein, Meckel syndrome type 1 protein, POC12 centriolar protein homolog
Species: human

Top Publications

  1. ncbi Periodic limb movement disorder is associated with normal motor conduction latencies when studied by central magnetic stimulation--successful use of a new technique
    R C Smith
    Department of Medicine, Michigan State University, East Lansing 48824
    Sleep 15:312-8. 1992
  2. ncbi Extracellular matrix receptors and the differentiation of human megakaryocytes in vitro
    A Molla
    , UMR CNRS UJF 5538, Institut Albert Bonniot, La Tronche, France
    Leuk Lymphoma 33:15-23. 1999
  3. ncbi Meckel syndrome in the Hutterite population is actually a Joubert-related cerebello-oculo-renal syndrome
    Kym M Boycott
    Department of Medical Genetics, Alberta Children s Hospital and University of Calgary, Calgary, Alberta, Canada
    Am J Med Genet A 143:1715-25. 2007
  4. ncbi Spleen and bone marrow megakaryocytes as targets for inhaled vanadium
    Teresa I Fortoul
    Cellular and Tissular Biology Department, School of Medicine, National University of Mexico UNAM, Mexico City, Mexico
    Histol Histopathol 23:1321-6. 2008
  5. ncbi Differential diagnosis between chronic granulocytic leukemia, polycythaemia vera and essential thrombocythemia using micro-and ultrastructural measurement data performed at the level of megakaryocyte
    R Schelker
    Department of Cell and Molecular Biology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    Rom J Morphol Embryol 50:595-603. 2009
  6. pmc Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins
    Nathan J Bialas
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
    J Cell Sci 122:611-24. 2009
  7. ncbi Displacement chromatography of proteins using a self-sharpening pH front formed by adsorbed buffering species as the displacer
    C R Narahari
    Department of Chemical and Biochemical Engineering, University of Maryland, Baltimore 21250, USA
    J Chromatogr A 825:115-26. 1998
  8. ncbi Multistage evaluation scale, differential threshold steps and equivalent sensation contours of respiratory flow-resistive load sensation
    L F Zhang
    Department of Aviation Environmental Physiology, Fourth Military Medical College, Xi an
    Sci Sin B 31:204-16. 1988
  9. pmc Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Br J Pharmacol 113:1349-57. 1994
  10. ncbi Trace determination of iron in water at the microgram/l level by on-line coupling of capillary isotachophoresis and capillary zone electrophoresis with UV detection of the EDTA-Fe (III) complex
    P Blatný
    Department of Carbohydrate Chemistry and Technology, Institute of Chemical Technology, Prague, Czech Republic
    J Chromatogr A 757:297-302. 1997

Research Grants

  1. NFE2 AND BETA 1 TUBULIN IN PLATELET DIFFERENTIATION
    Ramesh Shivdasani; Fiscal Year: 2003
  2. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2009
  3. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2010
  4. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2007
  5. Mechanisms Regulating Megakaryocyte Endomitosis
    Katya Ravid; Fiscal Year: 2010
  6. Mechanisms Regulating Megakaryocyte Endomitosis
    Katya Ravid; Fiscal Year: 2009
  7. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2002
  8. MKL in megakaryocytopoiesis
    Diane S Krause; Fiscal Year: 2010
  9. GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESIS
    Kenneth Kaushansky; Fiscal Year: 2006
  10. Abnormal Megakaryocyte Development
    Jonathan Drachman; Fiscal Year: 2003

Detail Information

Publications132 found, 100 shown here

  1. ncbi Periodic limb movement disorder is associated with normal motor conduction latencies when studied by central magnetic stimulation--successful use of a new technique
    R C Smith
    Department of Medicine, Michigan State University, East Lansing 48824
    Sleep 15:312-8. 1992
    ..Subjects had no other medical or sleep problems. A novel magnetic stimulator, the Cadwell MES-10, was discharged over the vertex and the C7 cervical spine...
  2. ncbi Extracellular matrix receptors and the differentiation of human megakaryocytes in vitro
    A Molla
    , UMR CNRS UJF 5538, Institut Albert Bonniot, La Tronche, France
    Leuk Lymphoma 33:15-23. 1999
    ..of extracellular matrix receptors (or integrins) in the course of the differentiation of human megakaryocytes (Mks) leading to the formation of platelets...
  3. ncbi Meckel syndrome in the Hutterite population is actually a Joubert-related cerebello-oculo-renal syndrome
    Kym M Boycott
    Department of Medical Genetics, Alberta Children s Hospital and University of Calgary, Calgary, Alberta, Canada
    Am J Med Genet A 143:1715-25. 2007
    Meckel syndrome (MKS) is a rare lethal autosomal recessive disorder characterized by the presence of occipital encephalocele, cystic kidneys, fibrotic changes of the liver and polydactyly...
  4. ncbi Spleen and bone marrow megakaryocytes as targets for inhaled vanadium
    Teresa I Fortoul
    Cellular and Tissular Biology Department, School of Medicine, National University of Mexico UNAM, Mexico City, Mexico
    Histol Histopathol 23:1321-6. 2008
    ..The increase in quantity and size of megakaryocytes (MKs) in the exposed group in both organs was striking...
  5. ncbi Differential diagnosis between chronic granulocytic leukemia, polycythaemia vera and essential thrombocythemia using micro-and ultrastructural measurement data performed at the level of megakaryocyte
    R Schelker
    Department of Cell and Molecular Biology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    Rom J Morphol Embryol 50:595-603. 2009
    ..The purpose of this paper is to compare different morphological parameters in MKs from patients diagnosed with three CMDs and to establish a differential diagnosis of these disorders...
  6. pmc Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins
    Nathan J Bialas
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada
    J Cell Sci 122:611-24. 2009
    ..An identifying feature of MKS1, one of six MKS-associated proteins, is the presence of a B9 domain of unknown function...
  7. ncbi Displacement chromatography of proteins using a self-sharpening pH front formed by adsorbed buffering species as the displacer
    C R Narahari
    Department of Chemical and Biochemical Engineering, University of Maryland, Baltimore 21250, USA
    J Chromatogr A 825:115-26. 1998
    ..of acetic acid and either 3-(N-morpholino)propane-sulfonic acid (MOPS) or 2-(N-morpholino)ethanesulfonic acid (MES). Sample loads up to 150 mg of protein were applied to a 75 x 7...
  8. ncbi Multistage evaluation scale, differential threshold steps and equivalent sensation contours of respiratory flow-resistive load sensation
    L F Zhang
    Department of Aviation Environmental Physiology, Fourth Military Medical College, Xi an
    Sci Sin B 31:204-16. 1988
    ..A new kind of category scale, the multistage evaluation scale (MES), based on a fuzzy set category judgement model for quantifying respiratory sensory magnitude has been put forward ..
  9. pmc Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil
    W Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Br J Pharmacol 113:1349-57. 1994
    ..The threshold for maximal (tonic) electroshock seizures (MES) was significantly increased by GYKI 52466 (10-20 mg kg-1), NBQX (80-120 mg kg-1) and diazepam (5 mg kg-1) shortly ..
  10. ncbi Trace determination of iron in water at the microgram/l level by on-line coupling of capillary isotachophoresis and capillary zone electrophoresis with UV detection of the EDTA-Fe (III) complex
    P Blatný
    Department of Carbohydrate Chemistry and Technology, Institute of Chemical Technology, Prague, Czech Republic
    J Chromatogr A 757:297-302. 1997
    ..1% hydroxypropylmethyl cellulose (pH 6.0), 5 mmol/l MES, and 25 mmol/l MES + 10 mmol/l bis-tris-propane (pH 6...
  11. doi Combination of cor triatriatum sinistrum and hypoplastic left heart syndrome in Meckel-Gruber syndrome: a case report
    Mana Taweevisit
    Department of Pathology, Faculty of Medicine, Chulalongkorn University, 1873 King Rama IV Street, Pathumwan, Bangkok, Thailand
    Pediatr Dev Pathol 12:404-9. 2009
    Meckel-Gruber syndrome (MKS) is a fatal, autosomal recessive disorder characterized by malformation of central nervous system, particularly occipital encephalocele, bilateral renal dysplasia, and polydactyly...
  12. pmc The Meckel-Gruber syndrome gene, MKS3, is mutated in Joubert syndrome
    Lekbir Baala
    INSERM U 781, Hopital Necker Enfants Malades, Paris, France
    Am J Hum Genet 80:186-94. 2007
    ..obvious phenotypic overlap between JS and MKS, we hypothesized that mutations in the recently identified MKS genes, MKS1 on chromosome 17q and MKS3 on 8q, may be a cause of JS...
  13. ncbi The anticonvulsant activities of N-benzyl 3-methoxypropionamides
    S V Andurkar
    Department of Chemistry, University of Houston, TX 77204-5641, USA
    Bioorg Med Chem 7:2381-9. 1999
    We recently reported that the ED50 value for (R,S)-2,3-dimethoxypropionamide (1) in the maximal electroshock (MES)-induced seizure test in mice was 30 mg/kg (Choi, D.; Stables, J.P., Kohn, H. Bioorg. Med. Chem. 1996, 4, 2105)...
  14. ncbi Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome
    Melissa A Fath
    Department of Pediatrics, Division of Medcal Genetics, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 14:1109-18. 2005
    McKusick-Kaufman syndrome (MKS) is an autosomal recessive disorder characterized by post-axial polydactyly, congenital heart defects and hydrometrocolpos, a congenital structural abnormality of female genitalia...
  15. ncbi [Role of histamine H(1) and H(2) receptors in the modulation of respiratory rhythmical discharge in medulla oblongata slice preparation of neonatal rats]
    Ying Qi
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Sheng Li Xue Bao 60:397-402. 2008
    ..hypoglossal nerve rootlets was prepared and the surgical procedure was performed in the modified Kreb's solution (MKS) with continuous carbogen (95% O(2) and 5% CO(2)), and ended in 3 min...
  16. pmc Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome
    Cheng Cui
    University of Pittsburgh, Department of Developmental Biology, 8111 Rangos Research Center, 530 45th Street, Pittsburgh, PA 15201, USA
    Dis Model Mech 4:43-56. 2011
    ..We recovered a mouse mutant with a mutation in the Mks1 gene (Mks1(del64-323)) that caused a 260-amino-acid deletion spanning nine amino acids in the B9 domain, a protein ..
  17. pmc The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation
    Wendy A Ciovacco
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA
    Bone 44:80-6. 2009
    ..Recently, we reported that megakaryocytes (MKs) enhance osteoblast (OB) proliferation by a juxtacrine signaling mechanism...
  18. ncbi Mutations of the CEP290 gene encoding a centrosomal protein cause Meckel-Gruber syndrome
    Valeska Frank
    Department of Human Genetics, RWTH Aachen University, Aachen, Germany
    Hum Mutat 29:45-52. 2008
    ..Recently, genes for MKS1 and MKS3 were identified, putting MKS on the list of ciliary disorders (ciliopathies)...
  19. ncbi Mutations in MKKS cause Bardet-Biedl syndrome
    A M Slavotinek
    Genetic Diseases Research Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA
    Nat Genet 26:15-6. 2000
    ..Some BBS cases (approximately 10%) remain unassigned to the five previously mapped loci. McKusick-Kaufma syndrome (MKS) includes hydrometrocolpos, postaxial polydactyly and congenital heart disease, and is also inherited in an ..
  20. ncbi Expression of bone morphogenetic proteins and their receptors in the bone marrow megakaryocytes of GATA-1(low) mice: a possible role in osteosclerosis
    Rama Garimella
    University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Histochem Cytochem 55:745-52. 2007
    ..However, growth factors released from the bone marrow cells, including from MKs, have been implicated in myelofibrosis, osteosclerosis, and angiogenesis...
  21. ncbi Preferential ex vivo expansion of megakaryocytes from human cord blood CD34+-enriched cells in the presence of thrombopoietin and limiting amounts of stem cell factor and Flt-3 ligand
    Chantal Proulx
    Research and Development, HEMA QUEBEC, Canada
    J Hematother Stem Cell Res 12:179-88. 2003
    ..of the key factor of megakaryopoiesis, thrombopoietin (TPO), permit the ex vivo expansion of megakaryocytes (MKs) for possible use in early post-transplant support of patients and the production of functional platelets for ..
  22. ncbi Metabolism and cell biology of vitamin K
    Martin J Shearer
    Centre for Haemostasis and Thrombosis, St Thomas Hospital, Westminster Bridge Road, London, UK
    Thromb Haemost 100:530-47. 2008
    ..vitamin K compounds comprise a plant form, phylloquinone (vitamin K(1)) and a series of bacterial menaquinones (MKs) (vitamin K(2))...
  23. ncbi [5-HT(1A) receptors are involved in the modulation of respiratory rhythmical discharge activity in the medulla oblongata slice preparation of neonatal rats]
    Zheng Qin
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Sheng Li Xue Bao 59:293-8. 2007
    ..The medulla oblongata slice was prepared and the surgical procedure was performed in the modified Kreb's solution (MKS) with continuous carbogen (95% O2 and 5% CO2), and ended in 3 min...
  24. ncbi [D(1)-dopamine receptor is involved in the modulation of the respiratory rhythmical discharge activity in the medulla oblongata slice preparation of neonatal rats in vitro.]
    Yong gang Jiao
    Department of Physiology, Southern Medical University, Guangzhou, China
    Sheng Li Xue Bao 60:704-8. 2008
    ..The medulla oblongata slice was prepared and the surgical procedure was performed in the modified Kreb's solution (MKS) with continuous ventilating 95% O2 and 5% CO2 and ended in 3 min...
  25. ncbi Kinetics of endomitosis in primary murine megakaryocytes
    C E Carow
    Department of Medicine, University of Washington, Seattle 98195 7710, USA
    J Cell Physiol 188:291-303. 2001
    Megakaryocytes (MKs) develop from diploid progenitor cells via successive rounds of DNA synthesis in the absence of cell division, a process termed endomitosis (EnM)...
  26. doi Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
    Kimie Nakagawa
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1, Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Nature 468:117-21. 2010
    ..the natural world in several forms, including a plant form, phylloquinone (PK), and a bacterial form, menaquinones (MKs)...
  27. ncbi Megakaryocytes and platelets in experimentally induced renovascular hypertension (2K1C) in rats
    Joanna Pawlak
    Department of Human Anatomy, Medical University of Białystok
    Postepy Hig Med Dosw (Online) 62:241-8. 2008
    ..Approximately 10% of the population with hypertension reveals the secondary type of the disease. The aim of the study was to evaluate the megakaryocyte-platelet system in the course of renovascular hypertension...
  28. pmc Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytes
    José P Young
    Dept of Physiology and Biophysics, Georgetown Univ, Columbia, Washington, DC 20057, USA
    Am J Physiol Cell Physiol 298:C602-10. 2010
    ..in a fluctuating fashion, triggering oscillatory outward Ca(2+)-activated K(+) currents in rat megakaryocytes (MKs)...
  29. ncbi Long-term platelet production assessed in NOD/SCID mice injected with cord blood CD34+ cells, thrombopoietin-amplified in clinical grade serum-free culture
    Gianfranco Mattia
    Department of Hematology, Oncology and Molecular Medicine, Section of Transfusion Methodologies, Istituto Superiore di Sanita, Rome, Italy
    Exp Hematol 36:244-52. 2008
    ..when induced to differentiate along the megakaryocytic (MK) lineage, retention of a low ploidy in the expanded MKs. Ex vivo expansion of CB hematopoietic progenitor cells for reconstitution of different human hematopoietic ..
  30. ncbi [Effect of glial cell metabolism on respiratory rhythmical discharge activity in neonatal rat medulla oblongata slices]
    Fang Fang
    Department of Physiology, Southern Medical University, Guangdong, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2410-3. 2009
    ..To explore the role of glial cell metabolism in the generation and regulation of central respiratory rhythm...
  31. doi Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling
    Larissa Lordier
    INSERM, U790, Villejuif, France
    Blood 112:3164-74. 2008
    ..No abnormality was observed in the central spindle of endomitotic MKs. A furrow formation was present, but the contractile ring was abnormal because accumulation of nonmuscle myosin IIA ..
  32. ncbi The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery
    Koji Eto
    Laboratory of Stem Cell Therapy, Center for Experimental Medicine, The Institute of Medical Science, University of Tokyo, Japan
    Blood 110:3637-47. 2007
    ..While MKs and platelets principally express WAVE1 and WAVE2, which are associated with Abi1, the physiologic significance of ..
  33. pmc Identification of CC2D2A as a Meckel syndrome gene adds an important piece to the ciliopathy puzzle
    Jonna Tallila
    National Public Health Institute, Institute for Molecular Medicine Finland, Helsinki 00290, Finland
    Am J Hum Genet 82:1361-7. 2008
    Meckel syndrome (MKS) is a lethal malformation disorder characterized classically by encephalocele, polycystic kidneys, and polydactyly. MKS is also one of the major contributors to syndromic neural tube defects (NTDs)...
  34. ncbi Prenatal diagnosis of the Meckel-Gruber syndrome from 11th to 20th gestational week
    C Mittermayer
    Department of Neonatology and Intensive Care, University Hospital Vienna
    Ultraschall Med 25:275-9. 2004
    The Meckel-Gruber syndrome (MKS) is a rare autosomal recessive disorder that is characterized by typical sonographical findings: occipital encephalocele, postaxial polydactyly and cystic enlargement of the kidneys...
  35. pmc Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy
    Donald J McCrann
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118, USA
    Blood 114:1243-9. 2009
    Megakaryocytes (MKs) undergo an endomitotic cell cycle, leading to polyploidy...
  36. pmc Normal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4
    Corey L Williams
    Department of Cell Biology, University of Alabama at Birmingham Medical Center, Birmingham, Alabama, USA
    J Am Soc Nephrol 21:782-93. 2010
    ..to renal cyst formation in multiple human syndromes including nephronophthisis (NPHP), Meckel-Gruber syndrome (MKS), Joubert syndrome (JBTS), and Bardet-Beidl syndrome (BBS)...
  37. ncbi Microembolic signals and clinical outcome in patients with acute stroke--a prospective study
    A Delcker
    Department of Neurology, University of Essen, Germany
    Eur Arch Psychiatry Clin Neurosci 250:1-5. 2000
    The occurrence of microembolic signals (MES) in patients with transient ischemic attack (TIA) or stroke has already been described; the influence of the time interval between onset of symptoms and transcranial Doppler monitoring (TCD) on ..
  38. ncbi Megakaryocyte population in human bone marrow increases with estrogen treatment: a role in bone remodeling?
    S Bord
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Bone 27:397-401. 2000
    ..b>MKs were identified morphologically, and the bone marrow cell population and MK number quantified by cell counting in a ..
  39. ncbi Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression
    Amy E Geddis
    Department of Pediatrics, Hematology Oncology, University of California, San Diego, La Jolla, California 92093, USA
    Cell Cycle 6:455-60. 2007
    ..We have postulated that anaphase in endomitotic MKs diverges from diploid mitosis at a point distal to the assembly of the midzone, possibly involving impaired ..
  40. ncbi New perspectives on keratoconus as revealed by corneal confocal microscopy
    Nathan Efron
    Institute of Health and Biomedical Innovation and School of Optometry, Queensland University of Technology, Brisbane, Australia
    Clin Exp Optom 91:34-55. 2008
    Confocal microscopy (CM) of keratoconus is reviewed. In the Manchester Keratoconus Study (MKS), slit scanning CM was used to evaluate 29 keratoconic patients and light microscopy (LM) was performed on two of the keratoconic corneas post-..
  41. ncbi [Effect of doxapram on the respiratory rhythmical discharge activity in the brainstem slice of neonatal rats]
    Guo cai Li
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:245-8. 2010
    ..To investigate the effects of doxapram on the respiratory rhythmical discharge activity (RRDA) in the brainstem slices of neonatal rats...
  42. ncbi [Role of 5-HT(2A) receptor in increase in respiratory-related rhythmic discharge activity by nikethamide in neonatal rat transverse medullary slices]
    Zhi bin Qian
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Sheng Li Xue Bao 60:216-20. 2008
    ..DOI), and an antagonist of 5-HT(2A) receptor, ketanserine, dissolved in modified Krebos solution (MKS)...
  43. ncbi CD41+/CD45+ cells without acetylcholinesterase activity are immature and a major megakaryocytic population in murine bone marrow
    Kuniko Matsumura-Takeda
    Molecular Medical Science Institute, Otsuka Pharmaceutical Co Ltd, 463 10 Kagasuno, Tokushima, Japan
    Stem Cells 25:862-70. 2007
    Murine megakaryocytes (MKs) are defined by CD41/CD61 expression and acetylcholinesterase (AChE) activity; however, their stages of differentiation in bone marrow (BM) have not been fully elucidated...
  44. pmc Suppressor analysis of a histone defect identifies a new function for the hda1 complex in chromosome segregation
    Hasna Kanta
    Department of Biological Sciences, University of Arkansas, Fayetteville 72701, USA
    Genetics 173:435-50. 2006
    ..We identified five genes, HHT1, MKS1, HDA1, HDA2, and HDA3, four of which encode proteins directly connected to chromatin function: histone H3 and each ..
  45. ncbi Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1(low) mice
    Lucia Centurione
    Department of Biomorphology, University G D Annunzio, Chieti, Italy
    Blood 104:3573-80. 2004
    ..blocks megakaryocytic maturation between stage I and II, resulting in accumulation of defective megakaryocytes (MKs) in the tissues of GATA-1(low) mice...
  46. ncbi Identification and activation of Src family kinases in primary megakaryocytes
    Brian J Lannutti
    Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104 1256, USA
    Exp Hematol 31:1268-74. 2003
    ..In this study, we examine which of the eight Src family members are expressed in primary megakaryocytes (MKs) and determine which of these become activated in response to TPO.
  47. ncbi Vitamin K content of foods and dietary vitamin K intake in Japanese young women
    Maya Kamao
    Department of Hygienic Sciences, Kobe Pharmaceutical University, Kobe, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:464-70. 2007
    ..To obtain a closer estimate of dietary intake of phylloquinone (PK) and menaquinones (MKs), PK, MK-4 and MK-7 contents in food samples (58 food items) were determined by an improved high-performance liquid ..
  48. ncbi Classical Swine Fever: pathology of bone marrow
    J C Gomez-Villamandos
    Departamento Anatomía y Anatomía Patológica Comparadas, Edificio de Sanidad Animal, Campus Universitario de Rabanales, Cordoba, Spain
    Vet Pathol 40:157-63. 2003
    ..Megakaryocytes (MKs) did not show significant changes in number, but there were important qualitative changes including 1) increased ..
  49. ncbi The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes
    P Rojnuckarin
    Division of Hematology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 276:41014-22. 2001
    ..ERK/mitogen-activated protein kinase pathway is important for TPO-induced endomitosis in primary megakaryocytes (MKs)...
  50. ncbi Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes
    Y Miyakawa
    Division of Hematology, University of Washington School of Medicine, Seattle 98195, USA
    J Biol Chem 276:2494-502. 2001
    ..Although many downstream signaling targets of TPO have been identified in cell lines, primary MKs, and platelets, the molecular mechanism(s) by which many of these molecules are activated remains uncertain...
  51. ncbi Differential expression of basal and hydrocarbon-induced cytochrome P-450 monooxygenase and quinone reductase activities in subpopulations of murine epidermal cells differing in their stages of differentiation
    J J Reiners
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center
    Drug Metab Dispos 20:360-6. 1992
    ..and 7-ethoxyresorufin O-deethylase (7-ERD) were measured in four subpopulations of murine epidermal keratinocytes (MKs) that differed in their stages of differentiation...
  52. ncbi [Glycine is involved in the modulation of respiratory rhythmical discharge activity in neonatal rat medullary brain slices]
    Jing Cheng
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:2142-5. 2008
    ..To determine the role of glycine (Gly) in the generation and modulation of basic respiratory rhythm...
  53. ncbi PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1)
    Takafumi Nakao
    Department of Medicine, Division of Hematology Oncology, University of California San Diego, La Jolla, California, USA
    Cell Cycle 7:257-66. 2008
    ..We found that TPO down-modulates p27(Kip1) expression at both the mRNA and protein levels in primary MKs in a PI3K dependent fashion...
  54. ncbi Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors
    Jennifer Antonchuk
    Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Blood 104:1306-13. 2004
    ..However, the number of megakaryocytic colony forming units (CFU-Mks) was significantly reduced, particularly in the spleen...
  55. ncbi Storage pool deficiency in cattle with the Chédiak-Higashi syndrome results from an absence of dense granule precursors in their megakaryocytes
    M Menard
    Department of Veterinary and Comparative Anatomy, Washington State University, Pullman 99164 6520
    Blood 72:1726-34. 1988
    ..Megakaryocytes (MKs) from five control (n = 135) and five CHS (n = 133) cattle were evaluated using standard transmission electron ..
  56. ncbi The suitability of 160Tb as a PAC probe for studies of biomolecules
    N P Sidhu
    Department of Physics, Punjabi University, Patiala, India
    Int J Rad Appl Instrum A 39:437-8. 1988
    The gamma-ray perturbed angular correlation (PAC) studies were made with 160Tb as a probe in MES (2[N-morpholino]-ethane sulphonic acid) solutions of various concentrations...
  57. doi Menaquinones, bacteria, and the food supply: the relevance of dairy and fermented food products to vitamin K requirements
    Barbara Walther
    Research Station Agroscope Liebefeld Posieux ALP, Bern, Switzerland
    Adv Nutr 4:463-73. 2013
    Vitamin K exists in the food supply as phylloquinone, a plant-based form and as menaquinones (MKs), a collection of isoprenologues mostly originating from bacterial synthesis...
  58. ncbi [Expression levels of CXCR4 on megakaryocytes and its ligand in bone marrow in children with acute idiopathic thrombocytopenic purpura]
    Guang yao Sheng
    Department of Pediatrics, the First Affiliated Hospital of Medical College, Zhengzhou University, Zhengzhou 450052, China
    Zhonghua Er Ke Za Zhi 42:499-501. 2004
    ..It has been revealed in recent years that they can induce mature and immature megakaryocytes (MKs) to migrate through bone marrow endothelial cells (BMEC) by increasing the affinity of MKs for BMEC...
  59. ncbi Determination of the basicity of Mannich ketones by capillary electrophoresis
    Zs Dobos
    Peptidbiochemical Research Group, Hungarian Academy of Sciences and Semmelweis University, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis Medical University, Puskin u 9, H 1088, Budapest, Hungary
    J Chromatogr B Analyt Technol Biomed Life Sci 799:179-83. 2004
    Capillary electrophoretic (CE) method to characterise Mannich ketones (MKs) containing morpholine moiety was developed...
  60. ncbi Accounting for strain-specific differences during RTG target gene regulation in Saccharomyces cerevisiae
    Ivanka Dilova
    Section of Molecular and Cellular Biology and Center for Genetics and Development, College of Biological Sciences, University of California, Davis, CA 95616, USA
    FEMS Yeast Res 6:112-9. 2006
    ..Two unresolved discrepancies exist with regard to the mechanism of RTG target gene control: (1) deletion of MKS1 results in constitutive expression of RTG target genes in most but not all strain backgrounds; and (2) RTG target ..
  61. pmc Canonical Wnt signaling in megakaryocytes regulates proplatelet formation
    Iain C Macaulay
    UCD Conway Institute, School of Biomedical and Biomolecular Science, University College Dublin, Dublin, Ireland
    Blood 121:188-96. 2013
    ..Here, we show that canonical and noncanonical Wnt signaling pathways are present and functional in megakaryocytes (MKs), with several Wnt effectors displaying MK-restricted expression...
  62. doi AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL
    M J Stankiewicz
    Department of Medicine, Northwestern University, Chicago, IL 60611, USA
    Leukemia 27:1339-47. 2013
    ..that constitutive AKT signaling is associated with a dramatic increase in apoptosis of WT megakaryocytes (MKs), but that overexpression of ERG blocks AKT-induced death...
  63. doi Frequency and characterization of gastro-entero-pancreatic neuroendocrine tumor patients with high-grade of uptake at somatostatin receptor scintigraphy
    Cecile N Chougnet
    Departments of Nuclear Medicine and Endocrine Tumors, Institut Gustave Roussy, University Paris Sud, 114 rue Edouard Vaillant, 94805 Villejuif Cedex, France
    Endocr Relat Cancer 20:229-39. 2013
    ..was reviewed by three independent readers and classified into four subgroups based on a modified Krenning's scale (mKS): no uptake (group-0), homogeneous grade 1-2 uptake (group-1), homogeneous grade 3-4 (group-2), and heterogeneous ..
  64. doi Earliest ultrasound findings and description of splicing mutations in Meckel-Gruber syndrome
    Christel Eckmann-Scholz
    Department of Gynecology and Obstetrics, University Hospital Schleswig Holstein, Campus Kiel and Christian Albrechts University Kiel, Arnold Heller Straße 3, 24105 Kiel, Germany
    Arch Gynecol Obstet 286:917-21. 2012
    To describe early ultrasound findings in Meckel-Gruber syndrome (MKS) in first and second trimester of three families, detailed ultrasound findings have been documented in addition to pathoanatomical findings and results of DNA studies...
  65. pmc FGF signaling facilitates postinjury recovery of mouse hematopoietic system
    Meng Zhao
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Blood 120:1831-42. 2012
    ..We identified megakaryocytes (Mks) as a major resource for FGF production, and further discovered a novel mechanism by which Mks underwent FGF-FGFR ..
  66. doi Single-cell level analysis of megakaryocyte growth and development
    Younes Leysi-Derilou
    Department of Chemical Engineering, Laval University, Quebec, QC, Canada G1V 0A6
    Differentiation 83:200-9. 2012
    ..Conversely, only NIC treatment increased the endomitotic rate of megakaryocytes (MKs) leading to the formation of CB-MKs with ploidy level frequently observed with BM-MKs...
  67. doi Regulation of platelet biogenesis: insights from the May-Hegglin anomaly and other MYH9-related disorders
    Z Chen
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Thromb Haemost 7:272-6. 2009
    Megakaryocyte (MK) maturation culminates in release of blood platelets through proplatelet extensions. MKs presumably delay elaborating proplatelets until synthesis of platelet constituents is complete...
  68. doi The association of health literacy and socio-demographic factors with medication knowledge
    Jennifer R Marks
    University of Virginia, Division of General Internal Medicine, Charlottesville, VA 22908 0744, USA
    Patient Educ Couns 78:372-6. 2010
    ..To compare patient demographics and Rapid Estimate of Adult Literacy in Medicine (REALM) scores with respect to their ability to predict medication comprehension...
  69. doi Exposure of human megakaryocytes to high shear rates accelerates platelet production
    Claire Dunois-Lardé
    INSERM U765, Paris, France
    Blood 114:1875-83. 2009
    Platelets originate from megakaryocytes (MKs) by cytoplasmic elongation into proplatelets. Direct platelet release is not seen in bone marrow hematopoietic islands...
  70. pmc Common features of megakaryocytes and hematopoietic stem cells: what's the connection?
    Hui Huang
    Division of Pediatric Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biochem 107:857-64. 2009
    Megakaryocytes (Mks) are rare polyploid bone marrow cells whose function is to produce blood platelets...
  71. ncbi HLA in familial and nonfamilial Mediterranean Kaposi's sarcoma in Greece
    A Kaloterakis
    Second Department of Medicine, University of Athens Medical School, Greece
    Tissue Antigens 45:117-9. 1995
    Fifty-four (54) unrelated patients with Mediterranean Kaposi's sarcoma (MKS) and 8 patients members of 4 unrelated families with familial MKS were serotyped for HLA-A,B and DR antigens...
  72. doi Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins
    Julien Villeneuve
    INSERM U889 and Université Victor Segalen Bordeaux 2, France
    Exp Hematol 37:849-56. 2009
    ..Our study was designed to investigate their synthesis in megakaryocytes (MKs) and their storage in platelets.
  73. ncbi High-level expression of Mpl in platelets and megakaryocytes is independent of thrombopoietin
    K Cohen-Solal
    INSERM U 362, Institut Gustave Roussy, Villejuif, France
    Blood 93:2859-66. 1999
    ..Using RNase protection analysis, we found no differences in the levels of c-mpl transcripts in megakaryocytes (MKs) produced in vitro either in the presence or absence of TPO and in platelets (PLTs) obtained from mice ..
  74. ncbi Rapid enantiomeric separation of polychlorinated biphenyls by electrokinetic chromatography using mixtures of neutral and charged cyclodextrin derivatives
    C Garcia-Ruiz
    Departamento de Quimica Analitica, Facultad de Quimica, Universidad de Alcala, Alcala de Henares, Madrid, Spain
    J Chromatogr A 910:157-64. 2001
    ..room temperature were individually separated into their two enantiomers by using 2-morpholinoethanesulfonic acid (MES) buffer (pH 6...
  75. ncbi The occipital cortex is hyperexcitable in migraine: experimental evidence
    S K Aurora
    Department of Neurology, Henry Ford Health Sciences Center, 2799 West Grand Boulevard, Detroit, MI 48202-2689, USA
    Headache 39:469-76. 1999
    ..METHODS: Transcranial magnetic stimulation was performed using the Cadwell MES-10 stimulator. A circular coil, 9.5 cm in diameter, was applied to the occipital scalp (7 cm above the inion)...
  76. ncbi Results of flexor tendon repair of the hand by the motion-stable wire suture by Towfigh
    L C Olivier
    Section of Hand Surgery, Department of Traumatology, University Clinic Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Arch Orthop Trauma Surg 121:212-8. 2001
    We compared the motion-stable wire suture by Towfigh (MSWST) with a modified Kessler suture (MKS) by following up flexor tendon repairs (MSWST, n = 21/39 digits; MKS, n = 20/31 digits). For MSWST we found 31 (79.5%) "excellent", 3 (7...
  77. pmc Dynamin 3 participates in the growth and development of megakaryocytes
    Jo Anna Reems
    Northwest Tissue Services Puget Sound Blood Center, Department of Medicine, Hematology Division, University of Washington, Seattle, WA 98104, USA
    Exp Hematol 36:1714-27. 2008
    ..used to compare gene expression profiles from uncultured CD34+/CD38lo cells and culture-derived megakaryocytes (MKs)...
  78. pmc A study of P2X1 receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors
    Catherine Vial
    Department of Cell Physiology and Pharmacology, Medical Sciences Building, University of Leicester, University Road, Leicester, LE1 9HN
    Br J Pharmacol 135:363-72. 2002
    We have examined the role of ATP-dependent P2X(1) receptors in megakaryocytes (MKs) and platelets using receptor-deficient mice and selective agonists...
  79. ncbi Separation of beta-lactoglobulin A, B and C variants of bovine whey using capillary zone electrophoresis
    G R Paterson
    Food Science Section, New Zealand Dairy Research Institute, Palmerston North
    J Chromatogr A 700:105-10. 1995
    ..Three buffer systems [borate, 2-(N-morpholino)-ethanesulphonic acid (MES) and bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane (Bistris)] were examined over a range of pH values and ..
  80. doi Involvement of ERK1/2, p38 and PI3K in megakaryocytic differentiation of K562 cells
    Isabel Conde
    Department of Cellular and Molecular Medicine, Centro de Investigaciones Biologicas CSIC, Madrid, Spain
    Eur J Haematol 84:430-40. 2010
    ..In our experimental conditions, only STA-treated cells showed the phenotype of mature megakaryocytes (MKs) including GPIbalpha expression, DNA endoreduplication, and formation of platelet-like structures...
  81. doi c-Myb and GATA-1 alternate dominant roles during megakaryocyte differentiation
    P Garcia
    Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    J Thromb Haemost 9:1572-81. 2011
    ..Mice expressing low levels of c-Myb (c-Myb(low)) have an increased number of bone marrow megakaryocytes (MKs) and corresponding thrombocytosis...
  82. pmc Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos
    Chengtian Zhao
    Division of Craniofacial and Molecular Genetics, and Program in Genetics, Sackler School of Graduate Biomedical Studies, Tufts University, Boston, MA, USA
    EMBO J 30:2532-44. 2011
    ..Our studies demonstrate that IFT particle components, and a Meckel-Gruber syndrome 1 (MKS1)-related, B9 domain protein, B9d2, bind each other and contribute to the ciliary localization of Inversin (..
  83. pmc Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase
    Alexia Eliades
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 286:27630-8. 2011
    ..Here, we examined the expression and functions of LOX in megakaryocytes (MKs), the platelet precursors...
  84. pmc Pleiotropic effects of CEP290 (NPHP6) mutations extend to Meckel syndrome
    Lekbir Baala
    Université René Descartes et INSERM U 781, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Am J Hum Genet 81:170-9. 2007
    ..Three loci have been mapped (MKS1-MKS3), and two genes have been identified (MKS1/FLJ20345 and MKS3/TMEM67), whereas the gene at the MKS2 locus ..
  85. pmc Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation
    Alexandra Mazharian
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Blood 117:5198-206. 2011
    ..Conversely, the number of megakaryocytes (MKs) in the bone marrow of dasatinib-treated mice was increased and the ploidy of MKs derived from bone marrow ..
  86. pmc Down-regulation of stathmin expression is required for megakaryocyte maturation and platelet production
    Camelia Iancu-Rubin
    Division of Hematology and Medical Oncology, Department of Medicine, and Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA
    Blood 117:4580-9. 2011
    ..on dynamic changes in the microtubule (MT) cytoskeleton, the mechanisms responsible for regulation of MTs in MKs remain poorly defined...
  87. doi GSK-3β negatively regulates megakaryocyte differentiation and platelet production from primary human bone marrow cells in vitro
    Mayumi Ono
    The Keio Daiichi Sankyo Project on Genetics of Thrombosis, Keio University School of Medicine, Tokyo, Japan
    Platelets 22:196-203. 2011
    ..CD41 (+)/CD42b (+)/propidium iodide (-) cells in the large (MK)-sized cell population (day 8), as living mature MKs, were further cultured in the MKLI media in TWS119 (+/-) for 6 days...
  88. pmc Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes
    N Ronkina
    Institute of Biochemistry, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nucleic Acids Res 39:2503-18. 2011
    ..Here, we analyzed stress-induced IEG expression in MK2/3-deficient cells. Ablation of MKs causes a decrease of p38α level and p38-dependent IEG expression...
  89. ncbi Cervical muscle myoelectric response to acute experimental sternocleidomastoid pain
    J A Ashton Miller
    Department of Mechanical Engineering, University of Michigan, Ann Arbor
    Spine (Phila Pa 1976) 15:1006-12. 1990
    ..Cervical myoelectric signal (MES) root-mean-square (RMS) response to each injection was recorded from eight neck muscles over 8 minutes...
  90. ncbi Spectrum of MKS1 and MKS3 mutations in Meckel syndrome: a genotype-phenotype correlation. Mutation in brief #960. Online
    Rana Khaddour
    INSERM U 781, Hopital Necker Enfants Malades, Universite Rene Descartes, Paris, France
    Hum Mutat 28:523-4. 2007
    ..MKS is genetically heterogeneous and three loci have been mapped respectively on 17q23 (MKS1), 11q13 (MKS2), and 8q24 (MKS3)...
  91. pmc Inhibitory effects of megakaryocytic cells in prostate cancer skeletal metastasis
    Xin Li
    Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
    J Bone Miner Res 26:125-34. 2011
    ..Osteoclastic cellular activity has been proposed as an initiating event for skeletal metastasis. Megakaryocytes (MKs) inhibit osteoclastogenesis, which could have an impact on tumor establishment in bone...
  92. doi MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR
    Christina Luig
    Institute of Molecular Virology, Westfalische Wilhelms University, D 48149 Munster, Germany
    FASEB J 24:4068-77. 2010
    ..The importance of MKs for influenza virus propagation was further underscored by demonstrating reduced viral progeny in cells genetically ..
  93. doi Glial cells are involved in the exciting effects of doxapram on brainstem slices in vitro
    Guo cai Li
    Department of Physiology, Southern Medical University, Guangzhou 510515, People s Republic of China
    Cell Mol Neurobiol 30:667-70. 2010
    ..The slices were perfused with modified Kreb's solution (MKS), and the rhythmical respiratory discharge activity (RRDA) was simultaneously recorded from the XII nerve by using ..
  94. doi A journey to produce platelets in vitro
    Jo Anna Reems
    Puget Sound Blood Center, Seattle, Washington 98104, USA
    Transfusion 51:169S-176S. 2011
    ..task requires an appreciation of the regulatory mechanisms that occur during the development of megakaryocytes (MKs) and the subsequent biogenesis of functional platelets from mature MKs...
  95. ncbi [Changes in cyclin expression during proliferation and differentiation of CD34(+) cells derived from fetal liver induced by thrombopoietin]
    D C Ma
    Northern Hospital, Shenyang 110015
    Sheng Li Xue Bao 53:296-302. 2001
    ..06 10(5)/ml with 95% of CD41a(+) cells and 3% of CD34(+) cells after 12 d of culture. Most of the megakaryocytes (MKs) derived from FL were in 2 N ploidy class, and few in 4 N ploidy class, but no megakaryocytes ploidy class was ..
  96. pmc ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
    Philippe P Roux
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Microbiol Mol Biol Rev 68:320-44. 2004
    ..which are functions also known to be mediated by members of a growing family of MAPK-activated protein kinases (MKs; formerly known as MAPKAP kinases)...
  97. ncbi Changes in the redox state and composition of the quinone pool of Escherichia coli during aerobic batch-culture growth
    M Bekker
    Molecular Microbial Physiology Group, Swammerdam Institute for Life Sciences, BioCentrum, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    Microbiology 153:1974-80. 2007
    Ubiquinones (UQs) and menaquinones (MKs) perform distinct functions in Escherichia coli. Whereas, in general, UQs are primarily involved in aerobic respiration, the MKs serve as electron carriers in anaerobic respiration...
  98. pmc Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis
    Stefan O Ciurea
    Hematology Oncology Section, Department of Medicine, College of Medicine, University of Illinois at Chicago, IL, USA
    Blood 110:986-93. 2007
    ..IMF CD34+ cells generated 24-fold greater numbers of megakaryocytes (MKs) than normal CD34+ cells...
  99. ncbi Synthesis of osteoprotegerin and RANKL by megakaryocytes is modulated by oestrogen
    S Bord
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Br J Haematol 126:244-51. 2004
    To investigate the mechanisms by which megakaryocytes (MKs) may influence bone remodelling, CD34(+) cells were cultured for 6, 9 and 12 d with or without 17beta-oestradiol (E) and immunolocalized for osteoprotegerin (OPG), receptor ..
  100. ncbi Meckel syndrome: genetics, perinatal findings, and differential diagnosis
    Chih Ping Chen
    Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
    Taiwan J Obstet Gynecol 46:9-14. 2007
    ..Genetic heterogeneity of MKS has been established by three reported MKS loci, i.e., MKS1 on 17q23, MKS2 on 11q13, and MKS3 on 8q21.13-q22.1...
  101. ncbi Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes
    Alessandra Balduini
    Center of Excellence for Applied Biology, Department of Biochemistry, University of Pavia, Pavia, Italy
    Exp Cell Res 300:84-93. 2004
    The expression of the small GTPase Rap1 in human megakaryocytes (MKs) differentiated from cord blood (CB)-derived progenitors was investigated...

Research Grants67

  1. NFE2 AND BETA 1 TUBULIN IN PLATELET DIFFERENTIATION
    Ramesh Shivdasani; Fiscal Year: 2003
    ..This makes it necessary to understand how terminally differentiated megakaryocytes (MKs) fragment and release blood platelets...
  2. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2009
    ..Cellular and molecular mechanisms of platelet assembly within, and their release from, megakaryocytes (MKs) remain largely unknown...
  3. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2010
    ..Cellular and molecular mechanisms of platelet assembly within, and their release from, megakaryocytes (MKs) remain largely unknown...
  4. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2007
    ..The central role of platelets in common disorders makes it important to know how megakaryocytes (MKs) terminate differentiation and release platelets into the circulation...
  5. Mechanisms Regulating Megakaryocyte Endomitosis
    Katya Ravid; Fiscal Year: 2010
    Polyploidy, the increase of diploid DMA content per cell, occurs in a variety of cells, including megakaryocytes (MKs), where it is achieved by an endomitotic cell cycle. The degree of MK ploidy influences platelet level and quality...
  6. Mechanisms Regulating Megakaryocyte Endomitosis
    Katya Ravid; Fiscal Year: 2009
    Polyploidy, the increase of diploid DMA content per cell, occurs in a variety of cells, including megakaryocytes (MKs), where it is achieved by an endomitotic cell cycle. The degree of MK ploidy influences platelet level and quality...
  7. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2002
    ..It is hypothesized that disruption of chemokine network, and adhesive interactions between megakaryocytes (MKs) and bone marrow endothelium (BMEC) as it may occur during HIV infection, plays a seminal role in the failure of MK ..
  8. MKL in megakaryocytopoiesis
    Diane S Krause; Fiscal Year: 2010
    ..during megakaryocytic differentiation with the highest levels in the most mature polyploid megakaryocytes (Mks), 2) overexpression of wildtype (WT) MKL1 promotes Mk differentiation of human cell lines as well as primary murine ..
  9. GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESIS
    Kenneth Kaushansky; Fiscal Year: 2006
    ..the role of survivin, INCENP and Aurora kinases, and the integrity of the late anaphase checkpoint in polyploid MKs. Finally, as we recently participated in the cloning and initial characterization of a new cytokine, a fourth ..
  10. Abnormal Megakaryocyte Development
    Jonathan Drachman; Fiscal Year: 2003
    ..a "systems biology" approach will be applied to study and interpret the molecular fingerprint of abnormal MKs and platelets from these pedigrees in comparison to normal individuals...
  11. Abnormal Megakaryocyte Development
    DIANA GILLIGAN; Fiscal Year: 2006
    ..a "systems biology" approach will be applied to study and interpret the molecular fingerprint of abnormal MKs and platelets from these pedigrees in comparison to normal individuals...
  12. Cytoskeletal Mechanisms of Platelet Formation
    Joseph Italiano; Fiscal Year: 2005
    ..Dynamic changes in the MT cytoskeleton will be observed as it functions in living MKs to establish the contribution of MT assembly and/or sliding in proplatelet elongation and MT coil formation...
  13. Regulation of nitrogen catabolic gene expression in S cerevisiae
    Terrance G Cooper; Fiscal Year: 2010
    ..For example, Tor regulation was thought to occur via Mks1, which was posited to be a negative regulator of Ure2 and positive regulator of Gln3...
  14. Regulation of nitrogen catabolic gene expression in S cerevisiae
    TERRANCE COOPER; Fiscal Year: 2007
    ..For example, Tor regulation was thought to occur via Mks1, which was posited to be a negative regulator of Ure2 and positive regulator of Gln3...
  15. A Model for Nephronophthisis in Caenorhabditis elegans
    Maureen M Barr; Fiscal Year: 2010
    ..kidney disease (ADPKD), autosomal recessive PKD, Bardet-Biedl Syndrome (BBS), and Meckel Gruber Syndrome (MKS)...
  16. Molecular Genetics of BBS
    Nicholas Katsanis; Fiscal Year: 2010
    ..include polycystic kidney disease (PKD), Nephronophthisis (NPHP), Joubert syndrome (JS) and Meckel-Gruber syndrome (MKS)...
  17. Molecular Genetics of BBS
    Nicholas Katsanis; Fiscal Year: 2009
    ..include polycystic kidney disease (PKD), Nephronophthisis (NPHP), Joubert syndrome (JS) and Meckel-Gruber syndrome (MKS)...
  18. Molecular Genetics of BBS
    Nicholas Katsanis; Fiscal Year: 2009
    ..include polycystic kidney disease (PKD), Nephronophthisis (NPHP), Joubert syndrome (JS) and Meckel-Gruber syndrome (MKS)...
  19. Bioengineering challenges for platelet production from hematopoietic stem cells
    William M Miller; Fiscal Year: 2010
    ..Production of autologous or compatible platelets by megakaryocytic cells (Mks) derived from cultured hematopoietic stem and progenitor cells (HSPCs or CD34+ cells) would greatly decrease these ..
  20. Novel Wnt effectors in renal cystic disease
    Erica Davis; Fiscal Year: 2007
    ..include polycystic kidney disease (PKD), Nephronophthisis (NPHP), Joubert syndrome (JS) and Meckel-Gruber syndrome (MKS)...
  21. Thrombopoietin Signaling: The Role of Src Kinases
    BRIAN LANNUTTI; Fiscal Year: 2007
    ..Understanding the signaling mechanisms of Mp1 and its interactions with other signaling molecules may lead to novel approaches in the treatment of a number of hematologic and other diseases. ..
  22. THE ROLE OF PL3K IN THROMBOPOIETIN SIGNALING
    Amy Geddis; Fiscal Year: 2005
    ..A defined plan of training is presented in which the applicant will develop the experience and skills necessary for success as an independent investigator in Hematology. ..
  23. Mechanisms Regulating Megakaryocyte Endomitosis
    Katya Ravid; Fiscal Year: 2007
    Polyploidy, the increase of diploid DNA content per cell, occurs in a variety of cells, including megakaryocytes (MKs), where it is achieved by an endomitotic cell cycle. The degree of MK ploidy influences platelet level and quality...