Gene Symbol: MKP6
Description: dual specificity phosphatase 14
Alias: MKP-L, MKP6, dual specificity protein phosphatase 14, MAP kinase phosphatase 6, MKP-1-like protein tyrosine phosphatase, MKP-6, mitogen-activated protein kinase phosphatase 6
Species: human
Products:     MKP6

Top Publications

  1. Galvão J, Iwao K, Apara A, Wang Y, Ashouri M, Shah T, et al. The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration. Invest Ophthalmol Vis Sci. 2018;59:2736-2747 pubmed publisher
    ..These results link intrinsic and extrinsic regulators of axon growth and suggest modulation of the KLF9-Dusp14 pathway as a potential approach to improve regeneration in the adult CNS after injury. ..
  2. Jianrong S, Yanjun Z, Chen Y, Jianwen X. DUSP14 rescues cerebral ischemia/reperfusion (IR) injury by reducing inflammation and apoptosis via the activation of Nrf-2. Biochem Biophys Res Commun. 2019;: pubmed publisher
    ..Dual-specificity phosphatase 14 (DUSP14, also known as MKP6) is a MAP kinase phosphatase, playing important role in regulating various cellular processes, including oxidative ..
  3. Tang N, Wang X, Chang K, Chan C, Szeto N, Huang D, et al. Genetic susceptibility to Tuberculosis: Interaction between HLA-DQA1 and age of onset. Infect Genet Evol. 2019;68:98-104 pubmed publisher
    ..The results provide support for the hypothesis that there are different pathogenesis mechanisms causing clinical TB disease in different age groups, and that genetics probably play a substantial role only in young-onset TB. ..
  4. Lin B, Xu J, Feng D, Wang F, Wang J, Zhao H. DUSP14 knockout accelerates cardiac ischemia reperfusion (IR) injury through activating NF-?B and MAPKs signaling pathways modulated by ROS generation. Biochem Biophys Res Commun. 2018;501:24-32 pubmed publisher
    ..Suppressing DUSP14 exacerbated cardiac injury through activating NF-?B and MAPKs signaling pathways regulated by ROS production. Thus, DUSP14 could be a valuable target for developing treatments for myocardial IR injury. ..
  5. Ocak M, Gillman A, Bresee J, Zhang L, Vlad A, Müller C, et al. Folate receptor-targeted multimodality imaging of ovarian cancer in a novel syngeneic mouse model. Mol Pharm. 2015;12:542-53 pubmed publisher
    ..p. injection of tumor cells. An imaging protocol should combine one or more of the modalities, e.g., PET/CT or PET/MRI for optimal tumor detection and delineation from surrounding tissues. ..
  6. Yan F, Ying L, Li X, Qiao B, Meng Q, Yu L, et al. Overexpression of the transcription factor ATF3 with a regulatory molecular signature associates with the pathogenic development of colorectal cancer. Oncotarget. 2017;8:47020-47036 pubmed publisher
    ..Our findings have important implications for CRC tumorigenesis and may be exploited for diagnostic and therapeutic purposes. ..
  7. Zhao B, Keasey S, Tropea J, Lountos G, Dyas B, Cherry S, et al. Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. PLoS ONE. 2015;10:e0134984 pubmed publisher
    ..These newly identified DUSP substrates will be important for examining structure-activity relationships with physiologically relevant targets. ..
  8. Yang C, Chiu L, Tan T. TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. Cell Signal. 2016;28:145-51 pubmed publisher
    Dual-specificity phosphatase 14 (DUSP14, also known as MKP6) is a MAP kinase phosphatase that dephosphorylates JNK, ERK, and p38 in vitro...
  9. Wang S, Yan Z, Yang X, An S, Zhang K, Qi Y, et al. Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver. Hepatology. 2017;: pubmed publisher

More Information


  1. Wang X, Mao W, Fang C, Tian S, Zhu X, Yang L, et al. Dusp14 protects against hepatic ischaemia-reperfusion injury via Tak1 suppression. J Hepatol. 2017;: pubmed publisher
    ..Dusp14 protects against liver damage by suppressing the activity of Tak1. Targeting Dusp14 could be a strategy for prevention and treatment of this disease. ..
  2. Li C, Zhou Q, Yang L, Chen Y, Hou J, Guo K, et al. Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway. Basic Res Cardiol. 2016;111:19 pubmed publisher
    ..Future studies are warranted to test the feasibility of overexpressing Dusp14 as a therapeutic strategy to attenuate cardiac hypertrophy and failure. ..
  3. Marti F, Krause A, Post N, Lyddane C, Dupont B, Sadelain M, et al. Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6. J Immunol. 2001;166:197-206 pubmed, we cloned a novel CD28 cytoplasmic tail (CD28 CYT) interacting protein, MAP kinase phosphatase-6 (MKP6), which we demonstrate inactivates MAP kinases...
  4. Zheng H, Li Q, Chen R, Zhang J, Ran Y, He X, et al. The dual-specificity phosphatase DUSP14 negatively regulates tumor necrosis factor- and interleukin-1-induced nuclear factor-?B activation by dephosphorylating the protein kinase TAK1. J Biol Chem. 2013;288:819-25 pubmed publisher
    ..Our study reveals a new post-translational regulatory mechanism of NF-?B activation triggered by the proinflammatory cytokines. ..
  5. Barreiro L, Tailleux L, Pai A, Gicquel B, Marioni J, Gilad Y. Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A. 2012;109:1204-9 pubmed publisher
    ..We thus identified a number of candidate loci, including the MAPK phosphatase DUSP14 in particular, that are promising susceptibility genes to pulmonary TB. ..
  6. Thye T, Vannberg F, Wong S, Owusu Dabo E, Osei I, Gyapong J, et al. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nat Genet. 2010;42:739-741 pubmed publisher
    ..13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low. ..
  7. Lountos G, Tropea J, Cherry S, Waugh D. Overproduction, purification and structure determination of human dual-specificity phosphatase 14. Acta Crystallogr D Biol Crystallogr. 2009;65:1013-20 pubmed publisher
    ..88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported...
  8. Patterson K, Brummer T, O Brien P, Daly R. Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J. 2009;418:475-89 pubmed
    ..The present review provides an overview of the DUSP family before focusing on atypical DUSPs, emerging as a group of proteins with vastly diverse substrate specificity and function. ..
  9. Elass E, Coddeville B, Kremer L, Mortuaire M, Mazurier J, Guerardel Y. Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages. FEBS Lett. 2008;582:445-50 pubmed publisher
    ..These findings suggest that the binding of LM to TLR2 triggers MAPK activation, followed by an up-regulation of MKP-1 expression, which in turn may act as a negative regulator of MAPK activation. ..
  10. Nyati M, Feng F, Maheshwari D, Varambally S, Zielske S, Ahsan A, et al. Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation. Cancer Res. 2006;66:11554-9 pubmed
    ..These findings show a new function for ATM in the control of mitogenic pathways affecting cell signaling and emphasize the key role of ATM in coordinating the cellular response to DNA damage. ..
  11. Hijikata M, Matsushita I, Le Hang N, Thuong P, Tam D, Maeda S, et al. Influence of the polymorphism of the DUSP14 gene on the expression of immune-related genes and development of pulmonary tuberculosis. Genes Immun. 2016;17:207-12 pubmed publisher
    ..63, 95% CI 0.44-0.90). Our results suggest that a low-expression genotype of DUSP14 accompanied by high transcript levels of Th1 immune-related genes may confer protection against early TB development. ..