MITF

Summary

Gene Symbol: MITF
Description: melanogenesis associated transcription factor
Alias: CMM8, COMMAD, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, class E basic helix-loop-helix protein 32, microphtalmia-associated transcription factor
Species: human
Products:     MITF

Top Publications

  1. Yasumoto K, Yokoyama K, Shibata K, Tomita Y, Shibahara S. Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. Mol Cell Biol. 1994;14:8058-70 pubmed
    ..of a ubiquitous transcription factor, USF, and a novel factor, microphthalmia-associated transcription factor (MITF), recently cloned as the human homolog of the mouse microphthalmia (mi) gene product...
  2. Huber W, Price E, Widlund H, Du J, Davis I, Wegner M, et al. A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes. J Biol Chem. 2003;278:45224-30 pubmed
    ..of melanocytes via activation of melanocyte-restricted microphthalmia-associated transcription factor (M-MITF) expression...
  3. Pierrat M, Marsaud V, Mauviel A, Javelaud D. Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-?. J Biol Chem. 2012;287:17996-8004 pubmed publisher
    The melanocyte-specific transcription factor M-MITF is involved in numerous aspects of melanoblast lineage biology including pigmentation, survival, and migration...
  4. Keenen B, Qi H, Saladi S, Yeung M, de la Serna I. Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma. Oncogene. 2010;29:81-92 pubmed publisher
    The microphthalmia-associated transcription factor (MITF) promotes melanocyte differentiation and cell-cycle arrest. Paradoxically, MITF also promotes melanoma survival and proliferation, acting like a lineage survival oncogene...
  5. Yokoyama S, Woods S, Boyle G, Aoude L, Macgregor S, Zismann V, et al. A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature. 2011;480:99-103 pubmed publisher
    ..E318K; rs149617956) in the melanoma-lineage-specific oncogene microphthalmia-associated transcription factor (MITF)...
  6. He S, Li C, Slobbe L, Glover A, Marshall E, Baguley B, et al. PAX3 knockdown in metastatic melanoma cell lines does not reduce MITF expression. Melanoma Res. 2011;21:24-34 pubmed publisher
    PAX3 and MITF are important transcriptional activators in the melanocyte lineage and PAX3 is thought to control MITF expression during normal melanocyte differentiation...
  7. Xu W, Gong L, Haddad M, Bischof O, Campisi J, Yeh E, et al. Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9. Exp Cell Res. 2000;255:135-43 pubmed
    The basic helix-loop-helix/leucine zipper (bHLH/ZIP) microphthalmia-associated transcription factor (MITF) regulates transcription of genes encoding enzymes essential for melanin biosynthesis in melanocytes and retinal pigmented ..
  8. Zhu S, Wurdak H, Wang Y, Galkin A, Tao H, Li J, et al. A genomic screen identifies TYRO3 as a MITF regulator in melanoma. Proc Natl Acad Sci U S A. 2009;106:17025-30 pubmed publisher
    ..Microphthalmia-associated transcription factor (MITF) is a master gene regulating melanocyte development and functions as a "lineage addiction" oncogene in ..
  9. Haq R, Shoag J, Andreu Pérez P, Yokoyama S, Edelman H, Rowe G, et al. Oncogenic BRAF regulates oxidative metabolism via PGC1? and MITF. Cancer Cell. 2013;23:302-15 pubmed publisher
    ..We further show that a target of BRAF, the melanocyte lineage factor MITF, directly regulates the expression of PGC1?...
  10. Sturm R, Fox C, McClenahan P, Jagirdar K, Ibarrola Villava M, Banan P, et al. Phenotypic characterization of nevus and tumor patterns in MITF E318K mutation carrier melanoma patients. J Invest Dermatol. 2014;134:141-149 pubmed publisher
    A germline polymorphism of the microphthalmia transcription factor (MITF) gene encoding a SUMOylation-deficient E318K-mutated protein has recently been described as a medium-penetrance melanoma gene...

Detail Information

Publications87

  1. Yasumoto K, Yokoyama K, Shibata K, Tomita Y, Shibahara S. Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. Mol Cell Biol. 1994;14:8058-70 pubmed
    ..of a ubiquitous transcription factor, USF, and a novel factor, microphthalmia-associated transcription factor (MITF), recently cloned as the human homolog of the mouse microphthalmia (mi) gene product...
  2. Huber W, Price E, Widlund H, Du J, Davis I, Wegner M, et al. A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes. J Biol Chem. 2003;278:45224-30 pubmed
    ..of melanocytes via activation of melanocyte-restricted microphthalmia-associated transcription factor (M-MITF) expression...
  3. Pierrat M, Marsaud V, Mauviel A, Javelaud D. Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-?. J Biol Chem. 2012;287:17996-8004 pubmed publisher
    The melanocyte-specific transcription factor M-MITF is involved in numerous aspects of melanoblast lineage biology including pigmentation, survival, and migration...
  4. Keenen B, Qi H, Saladi S, Yeung M, de la Serna I. Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma. Oncogene. 2010;29:81-92 pubmed publisher
    The microphthalmia-associated transcription factor (MITF) promotes melanocyte differentiation and cell-cycle arrest. Paradoxically, MITF also promotes melanoma survival and proliferation, acting like a lineage survival oncogene...
  5. Yokoyama S, Woods S, Boyle G, Aoude L, Macgregor S, Zismann V, et al. A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature. 2011;480:99-103 pubmed publisher
    ..E318K; rs149617956) in the melanoma-lineage-specific oncogene microphthalmia-associated transcription factor (MITF)...
  6. He S, Li C, Slobbe L, Glover A, Marshall E, Baguley B, et al. PAX3 knockdown in metastatic melanoma cell lines does not reduce MITF expression. Melanoma Res. 2011;21:24-34 pubmed publisher
    PAX3 and MITF are important transcriptional activators in the melanocyte lineage and PAX3 is thought to control MITF expression during normal melanocyte differentiation...
  7. Xu W, Gong L, Haddad M, Bischof O, Campisi J, Yeh E, et al. Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9. Exp Cell Res. 2000;255:135-43 pubmed
    The basic helix-loop-helix/leucine zipper (bHLH/ZIP) microphthalmia-associated transcription factor (MITF) regulates transcription of genes encoding enzymes essential for melanin biosynthesis in melanocytes and retinal pigmented ..
  8. Zhu S, Wurdak H, Wang Y, Galkin A, Tao H, Li J, et al. A genomic screen identifies TYRO3 as a MITF regulator in melanoma. Proc Natl Acad Sci U S A. 2009;106:17025-30 pubmed publisher
    ..Microphthalmia-associated transcription factor (MITF) is a master gene regulating melanocyte development and functions as a "lineage addiction" oncogene in ..
  9. Haq R, Shoag J, Andreu Pérez P, Yokoyama S, Edelman H, Rowe G, et al. Oncogenic BRAF regulates oxidative metabolism via PGC1? and MITF. Cancer Cell. 2013;23:302-15 pubmed publisher
    ..We further show that a target of BRAF, the melanocyte lineage factor MITF, directly regulates the expression of PGC1?...
  10. Sturm R, Fox C, McClenahan P, Jagirdar K, Ibarrola Villava M, Banan P, et al. Phenotypic characterization of nevus and tumor patterns in MITF E318K mutation carrier melanoma patients. J Invest Dermatol. 2014;134:141-149 pubmed publisher
    A germline polymorphism of the microphthalmia transcription factor (MITF) gene encoding a SUMOylation-deficient E318K-mutated protein has recently been described as a medium-penetrance melanoma gene...
  11. Liu F, Singh A, Yang Z, Garcia A, Kong Y, Meyskens F. MiTF links Erk1/2 kinase and p21 CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells. Mol Cancer. 2010;9:214 pubmed publisher
    As a survival factor for melanocytes lineage cells, MiTF plays multiple roles in development and melanomagenesis. What role MiTF plays in the DNA damage response is currently unknown...
  12. Denecker G, Vandamme N, Akay O, Koludrovic D, Taminau J, Lemeire K, et al. Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression. Cell Death Differ. 2014;21:1250-61 pubmed publisher
    ..Zeb2 in the melanocyte lineage results in a downregulation of the Microphthalmia-associated transcription factor (Mitf) and melanocyte differentiation markers concomitant with an upregulation of Zeb1...
  13. Mitra D, Fisher D. Transcriptional regulation in melanoma. Hematol Oncol Clin North Am. 2009;23:447-65, viii pubmed publisher
    ..networks of transcriptional activation and repression is microphthalmia-associated transcription factor (MITF), a melanocyte lineage marker that increases pigment production and exhibits diverse effects on cell survival, ..
  14. Shibahara S, Takeda K, Yasumoto K, Udono T, Watanabe K, Saito H, et al. Microphthalmia-associated transcription factor (MITF): multiplicity in structure, function, and regulation. J Investig Dermatol Symp Proc. 2001;6:99-104 pubmed
    Microphthalmia-associated transcription factor (MITF) regulates the differentiation and development of melanocytes and retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme ..
  15. Carreira S, Goodall J, Aksan I, La Rocca S, Galibert M, Denat L, et al. Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature. 2005;433:764-9 pubmed
    ..The microphthalmia-associated transcription factor Mitf has a crucial but poorly defined role in melanoblast and melanocyte survival and in differentiation...
  16. Wellbrock C, Rana S, Paterson H, Pickersgill H, Brummelkamp T, Marais R. Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF. PLoS ONE. 2008;3:e2734 pubmed publisher
    The Microphthalmia-associated transcription factor (MITF) is an important regulator of cell-type specific functions in melanocytic cells...
  17. Mansky K, Sankar U, Han J, Ostrowski M. Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling. J Biol Chem. 2002;277:11077-83 pubmed
    ..The microphthalmia transcription factor (MITF) is required for terminal differentiation of osteoclasts...
  18. Ondrusová L, Vachtenheim J, Réda J, Záková P, Benkova K. MITF-independent pro-survival role of BRG1-containing SWI/SNF complex in melanoma cells. PLoS ONE. 2013;8:e54110 pubmed publisher
    ..The central role in the melanoma transcriptional network has the transcription factor MITF (microphthalmia-associated transcription factor)...
  19. Fuse N, Yasumoto K, Suzuki H, Takahashi K, Shibahara S. Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene. Biochem Biophys Res Commun. 1996;219:702-7 pubmed
    Microphthalmia-associated transcription factor (MITF), the human homolog of the mouse microphthalmia gene product, regulates melanocyte-specific transcription of the tyrosinase gene that codes for an essential enzyme in melanin ..
  20. Bemis L, Chen R, Amato C, Classen E, Robinson S, Coffey D, et al. MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines. Cancer Res. 2008;68:1362-8 pubmed publisher
    Micropthalmia-associated transcription factor (MITF) is the master regulator of melanocyte development, survival, and function...
  21. Grill C, Bergsteinsdottir K, Ogmundsdóttir M, Pogenberg V, Schepsky A, Wilmanns M, et al. MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function. Hum Mol Genet. 2013;22:4357-67 pubmed publisher
    ..in patients with the dominantly inherited hypopigmentation and deafness syndromes Waardenburg syndrome type 2A (WS2A) and Tietz syndrome (TS)...
  22. Joo A, Aburatani H, Morii E, Iba H, Yoshimura A. STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression. Oncogene. 2004;23:726-34 pubmed
    ..We found that the microphthalmia-associated transcription factor (MITF), an essential transcription factor for melanocyte development and pigmentation, induces anchorage-independent ..
  23. Vachtenheim J, Ondrusová L, Borovansky J. SWI/SNF chromatin remodeling complex is critical for the expression of microphthalmia-associated transcription factor in melanoma cells. Biochem Biophys Res Commun. 2010;392:454-9 pubmed publisher
    The microphthalmia-associated transcription factor (MITF) is required for melanocyte development, maintenance of the melanocyte-specific transcription, and survival of melanoma cells...
  24. Cronin J, Wunderlich J, Loftus S, Prickett T, Wei X, Ridd K, et al. Frequent mutations in the MITF pathway in melanoma. Pigment Cell Melanoma Res. 2009;22:435-44 pubmed publisher
    Microphthalmia-associated transcription factor (MITF) is involved in melanocyte cell development, pigmentation and neoplasia...
  25. Widlund H, Horstmann M, Price E, Cui J, Lessnick S, Wu M, et al. Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol. 2002;158:1079-87 pubmed
    The transcription factor Microphthalmia-associated transcription factor (MITF) is a lineage-determination factor, which modulates melanocyte differentiation and pigmentation...
  26. Larribere L, Hilmi C, Khaled M, Gaggioli C, Bille K, Auberger P, et al. The cleavage of microphthalmia-associated transcription factor, MITF, by caspases plays an essential role in melanocyte and melanoma cell apoptosis. Genes Dev. 2005;19:1980-5 pubmed
    Microphthalmia-associated transcription factor (MITF) M-form is a melanocyte-specific transcription factor that plays a key role in melanocyte development, survival, and differentiation...
  27. Murakami H, Arnheiter H. Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner. Pigment Cell Res. 2005;18:265-77 pubmed
    The microphthalmia transcription factor MITF plays important roles in several cell lineages including retinal and neural crest-derived pigment cells...
  28. Fuse N, Yasumoto K, Takeda K, Amae S, Yoshizawa M, Udono T, et al. Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus. J Biochem. 1999;126:1043-51 pubmed
    Microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix-leucine zipper protein, and plays an important role in the development of various cell types, such as neural-crest-derived melanocytes and optic-cup-derived ..
  29. Wellbrock C, Marais R. Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation. J Cell Biol. 2005;170:703-8 pubmed
    ..Microphthalmia-associated transcription factor (MITF) is an important melanocyte differentiation and survival factor, but its role in melanoma is unclear...
  30. Shah M, Bhoumik A, Goel V, Dewing A, Breitwieser W, Kluger H, et al. A role for ATF2 in regulating MITF and melanoma development. PLoS Genet. 2010;6:e1001258 pubmed publisher
    ..Gene expression profiling identified higher MITF expression in primary melanocytes expressing transcriptionally inactive ATF2...
  31. Udono T, Yasumoto K, Takeda K, Amae S, Watanabe K, Saito H, et al. Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters. Biochim Biophys Acta. 2000;1491:205-19 pubmed
    Microphthalmia-associated transcription factor (MITF) affects the development of many types of cells, including melanocytes and retinal pigment epithelium (RPE)...
  32. Craig E, Spiegelman V. Inhibition of coding region determinant binding protein sensitizes melanoma cells to chemotherapeutic agents. Pigment Cell Melanoma Res. 2012;25:83-7 pubmed publisher
    ..Furthermore, inhibition of CRD-BP decreases microphthalmia-associated transcription factor (MITF) expression and reintroduction of MITF partially compensates for the absence of CRD-BP...
  33. Haflidadóttir B, Bergsteinsdóttir K, Praetorius C, Steingrímsson E. miR-148 regulates Mitf in melanoma cells. PLoS ONE. 2010;5:e11574 pubmed publisher
    The Microphthalmia associated transcription factor (Mitf) is an important regulator in melanocyte development and has been shown to be involved in melanoma progression...
  34. Amae S, Fuse N, Yasumoto K, Sato S, Yajima I, Yamamoto H, et al. Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium. Biochem Biophys Res Commun. 1998;247:710-5 pubmed
    Mutations at the mouse locus encoding microphthalmia-associated transcription factor (Mitf) affect the development of many cell types, including retinal pigment epithelium (RPE), melanocytes, mast cells, and osteoclasts...
  35. Tassabehji M, Newton V, Read A. Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene. Nat Genet. 1994;8:251-5 pubmed
    ..We recently mapped a WS2 gene to chromosome 3p12.3-p14.1 and proposed as a candidate gene MITF, the human homologue of the mouse microphthalmia (mi) gene...
  36. Feige E, Yokoyama S, Levy C, Khaled M, Igras V, Lin R, et al. Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF. Proc Natl Acad Sci U S A. 2011;108:E924-33 pubmed publisher
    Microphthalmia-associated transcription factor (MITF) regulates normal melanocyte development and is also a lineage-selective oncogene implicated in melanoma and clear-cell sarcoma (i.e., melanoma of soft parts)...
  37. Garraway L, Widlund H, Rubin M, Getz G, Berger A, Ramaswamy S, et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005;436:117-22 pubmed
    ..maps with gene expression signatures derived from NCI60 cell lines, we identified the melanocyte master regulator MITF (microphthalmia-associated transcription factor) as the target of a novel melanoma amplification...
  38. Kholmanskikh O, van Baren N, Brasseur F, Ottaviani S, Vanacker J, Arts N, et al. Interleukins 1alpha and 1beta secreted by some melanoma cell lines strongly reduce expression of MITF-M and melanocyte differentiation antigens. Int J Cancer. 2010;127:1625-36 pubmed publisher
    ..receptor exhibit 4- to 10-fold lower levels of mRNA of microphthalmia-associated transcription factor (MITF-M) when treated with interleukin-1beta. This effect is NF-kappaB and JNK-dependent...
  39. Tassabehji M, Newton V, Liu X, Brady A, Donnai D, Krajewska Walasek M, et al. The mutational spectrum in Waardenburg syndrome. Hum Mol Genet. 1995;4:2131-7 pubmed
    ..such as Waardenburg syndrome (WS) or probable neurocristopathies were screened for mutations in the PAX3 and MITF genes...
  40. Hughes A, Newton V, Liu X, Read A. A gene for Waardenburg syndrome type 2 maps close to the human homologue of the microphthalmia gene at chromosome 3p12-p14.1. Nat Genet. 1994;7:509-12 pubmed
    ..05 at zero recombination. Interestingly, the human homologue (MITF) of the mouse microphthalmia gene, a good candidate at the phenotypic level, has recently been mapped to 3p12.3-p14...
  41. Ghiorzo P, Pastorino L, Queirolo P, Bruno W, Tibiletti M, Nasti S, et al. Prevalence of the E318K MITF germline mutation in Italian melanoma patients: associations with histological subtypes and family cancer history. Pigment Cell Melanoma Res. 2013;26:259-62 pubmed publisher
    ..have recently identified a rare germline functional variant in the microphthalmia-associated transcription factor (MITF) (E318K) that predisposes to familial and sporadic melanoma and to renal cell carcinoma (RCC), showing a new link ..
  42. Konieczkowski D, Johannessen C, Abudayyeh O, Kim J, Cooper Z, Piris A, et al. A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors. Cancer Discov. 2014;4:816-27 pubmed publisher
    ..cell lines and patient biopsies showed high expression and activity of the melanocytic lineage transcription factor MITF, intrinsically resistant cell lines and biopsies displayed low MITF expression but higher levels of NF-?B signaling ..
  43. Adijanto J, Castorino J, Wang Z, Maminishkis A, Grunwald G, Philp N. Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression. J Biol Chem. 2012;287:20491-503 pubmed publisher
    ..Microphthalmia-associated transcription factor (MITF) is a key regulator of RPE differentiation that was also down-regulated in dedifferentiated hfRPE cells...
  44. McGill G, Haq R, Nishimura E, Fisher D. c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 2006;281:10365-73 pubmed
    ..the mechanism by which HGF up-regulates its receptor, we found that c-Met is a direct transcriptional target of Mitf. This was confirmed with chromatin immunoprecipitation experiments of the human c-Met promoter, as well as by the ..
  45. Vachtenheim J, Borovansky J. "Transcription physiology" of pigment formation in melanocytes: central role of MITF. Exp Dermatol. 2010;19:617-27 pubmed publisher
    ..The genes for melanin synthesis and deposition are coordinately expressed in melanocytes. The transcription factor MITF, which has been reported to activate more than 25 genes in pigment cells, has emerged as an essential regulator not ..
  46. Bertolotto C, Abbe P, Hemesath T, Bille K, Fisher D, Ortonne J, et al. Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes. J Cell Biol. 1998;142:827-35 pubmed
  47. Thurber A, Douglas G, Sturm E, Zabierowski S, Smit D, Ramakrishnan S, et al. Inverse expression states of the BRN2 and MITF transcription factors in melanoma spheres and tumour xenografts regulate the NOTCH pathway. Oncogene. 2011;30:3036-48 pubmed publisher
    ..cells within the melanoma spheres and mouse xenografts each displayed a high level of reciprocal BRN2 or MITF expression, which matched more closely the pattern seen in human melanoma tumours in situ, rather than the ..
  48. Du J, Miller A, Widlund H, Horstmann M, Ramaswamy S, Fisher D. MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma. Am J Pathol. 2003;163:333-43 pubmed
    The clinically important melanoma diagnostic antibodies HMB-45, melan-A, and MITF (D5) recognize gene products of the melanocyte-lineage genes SILV/PMEL17/GP100, MLANA/MART1, and MITF, respectively...
  49. Cheli Y, Giuliano S, Fenouille N, Allegra M, Hofman V, Hofman P, et al. Hypoxia and MITF control metastatic behaviour in mouse and human melanoma cells. Oncogene. 2012;31:2461-70 pubmed publisher
    ..In the present report, we show that deletion of microphthalmia-associated transcription factor (MITF), the master gene in melanocyte differentiation, is sufficient to increase the metastatic potential of mouse and ..
  50. Hemesath T, Price E, Takemoto C, Badalian T, Fisher D. MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature. 1998;391:298-301 pubmed
    ..The pathway represents a new application of the general MAP kinase machinery in transducing a signal between a tissue-specific receptor at the cell surface and a tissue-specific transcription factor in the nucleus. ..
  51. Loercher A, Tank E, Delston R, Harbour J. MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A. J Cell Biol. 2005;168:35-40 pubmed
    ..Here, we show that the master melanocyte differentiation factor, microphthalmia transcription factor (MITF), regulates cell cycle exit by activating the cell cycle inhibitor INK4A, a tumor suppressor that frequently is ..
  52. Liu F, Fu Y, Meyskens F. MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1. J Invest Dermatol. 2009;129:422-31 pubmed publisher
    Microphthalmia-associated transcription factor (MiTF) is a key transcription factor for melanocyte lineage survival. Most previous work on this gene has been focused on its role in development...
  53. Du J, Widlund H, Horstmann M, Ramaswamy S, Ross K, Huber W, et al. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell. 2004;6:565-76 pubmed
    ..expression, CDK2 exhibits tissue-specific regulation by the essential melanocyte lineage transcription factor MITF. In addition, functional studies revealed this regulation to be critical for maintaining CDK2 kinase activity and ..
  54. Chiaverini C, Beuret L, Flori E, Busca R, Abbe P, Bille K, et al. Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport. J Biol Chem. 2008;283:12635-42 pubmed publisher
    ..In this study, we show that microphthalmia-associated transcription factor (MITF) silencing induces melanosome gathering around the nucleus and causes the relocalization of Rab27A, Slac2a-Mlph, ..
  55. Guo J, Zhang J, Wang W, Cheung F, Lu Y, Ng C, et al. MicroRNA-218 inhibits melanogenesis by directly suppressing microphthalmia-associated transcription factor expression. RNA Biol. 2014;11:732-41 pubmed
    The microphthalmia-associated transcription factor (MITF) is a pivotal regulator of melanogenic enzymes for melanogenesis, and its expression is modulated by many transcriptional factors at the transcriptional level or post-..
  56. Busca R, Berra E, Gaggioli C, Khaled M, Bille K, Marchetti B, et al. Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells. J Cell Biol. 2005;170:49-59 pubmed
    ..we report that the melanocyte-specific transcription factor, microphthalmia-associated transcription factor (MITF), binds to the Hif1a promoter and strongly stimulates its transcriptional activity...
  57. Selzer E, Wacheck V, Lucas T, Heere Ress E, Wu M, Weilbaecher K, et al. The melanocyte-specific isoform of the microphthalmia transcription factor affects the phenotype of human melanoma. Cancer Res. 2002;62:2098-103 pubmed
    The microphthalmia transcription factor MITF plays a pivotal role in the development and differentiation of melanocytes...
  58. Genovese G, Ghosh P, Li H, Rettino A, Sioletic S, Cittadini A, et al. The tumor suppressor HINT1 regulates MITF and ?-catenin transcriptional activity in melanoma cells. Cell Cycle. 2012;11:2206-15 pubmed publisher
    ..that inhibits the Wnt/?-catenin pathway in colon cancer cells and Microphthalmia-associated transcription factor (MITF) activity in human mast cells...
  59. Primot A, Mogha A, Corre S, Roberts K, Debbache J, Adamski H, et al. ERK-regulated differential expression of the Mitf 6a/b splicing isoforms in melanoma. Pigment Cell Melanoma Res. 2010;23:93-102 pubmed publisher
    The master regulator of the melanocyte lineage Mitf is intimately involved in development as well as melanoma, controlling cell survival, differentiation, proliferation and metastasis/migration...
  60. Zhao X, Fiske B, Kawakami A, Li J, Fisher D. Regulation of MITF stability by the USP13 deubiquitinase. Nat Commun. 2011;2:414 pubmed publisher
    The microphthalmia-associated transcription factor (MITF) is essential for melanocyte development. Mutation-induced MAPK pathway activation is common in melanoma and induces MITF phosphorylation, ubiquitination, and proteolysis...
  61. Miller A, Levy C, Davis I, Razin E, Fisher D. Sumoylation of MITF and its related family members TFE3 and TFEB. J Biol Chem. 2005;280:146-55 pubmed
    b>MITF and its related family members TFE3 and TFEB heterodimerize with each other, recognize the same DNA sequences, and are subject to many of the same post-translational modifications...
  62. Smith S, Kelley P, Kenyon J, Hoover D. Tietz syndrome (hypopigmentation/deafness) caused by mutation of MITF. J Med Genet. 2000;37:446-8 pubmed
    ..This family was reascertained and a missense mutation was found in the basic region of the MITF gene in family members with Tietz syndrome...
  63. Carreira S, Goodall J, Denat L, Rodriguez M, Nuciforo P, Hoek K, et al. Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes Dev. 2006;20:3426-39 pubmed
    ..in melanomas invasiveness can be regulated epigenetically by the microphthalmia-associated transcription factor, Mitf, via regulation of the DIAPH1 gene encoding the diaphanous-related formin Dia1 that promotes actin polymerization ..
  64. Yan D, Dong X, Chen X, Yao S, Wang L, Wang J, et al. Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2. PLoS ONE. 2012;7:e40967 pubmed publisher
    ..Using bioinformatics, we identified three potential targets of miR-182, namely MITF, BCL2 and cyclin D2...
  65. Dynek J, Chan S, Liu J, Zha J, Fairbrother W, Vucic D. Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas. Cancer Res. 2008;68:3124-32 pubmed publisher
    ..Herein, we show that the lineage survival oncogene microphthalmia-associated transcription factor (MITF) is a critical regulator of ML-IAP transcription in melanoma cells...
  66. Borgdorff V, Rix U, Winter G, Gridling M, Müller A, Breitwieser F, et al. A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF. Oncogene. 2014;33:2531-9 pubmed publisher
    The microphthalmia-associated transcription factor (MITF) is indispensable for the viability of melanocytic cells, is an oncogene in melanoma and has a cell type-specific expression pattern...
  67. Bertolotto C, Lesueur F, Giuliano S, Strub T, de Lichy M, Bille K, et al. A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma. Nature. 2011;480:94-8 pubmed publisher
    ..The microphthalmia-associated transcription factor (MITF) has been proposed to act as a melanoma oncogene; it also stimulates the transcription of hypoxia inducible factor (..
  68. Javelaud D, Alexaki V, Pierrat M, Hoek K, Dennler S, van Kempen L, et al. GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells. Pigment Cell Melanoma Res. 2011;24:932-43 pubmed publisher
    ..correlated with that of the melanocyte-specific transcription factor M-microphthalmia transcription factor (M-MITF) and associated transcriptional program...
  69. Arnheiter H. The discovery of the microphthalmia locus and its gene, Mitf. Pigment Cell Melanoma Res. 2010;23:729-35 pubmed publisher
    The history of the discovery of the microphthalmia locus and its gene, now called Mitf, is a testament to the triumph of serendipity...
  70. McGill G, Horstmann M, Widlund H, Du J, Motyckova G, Nishimura E, et al. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell. 2002;109:707-18 pubmed
    Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken...
  71. Miller A, Du J, Rowan S, Hershey C, Widlund H, Fisher D. Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. Cancer Res. 2004;64:509-16 pubmed
    ..Similarly, the melanocytic markers MLANA/MART1 and MITF also have been shown to lose relative expression during melanoma progression...
  72. Luo C, Merz P, Chen Y, Dickes E, Pscherer A, Schadendorf D, et al. MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2. Cancer Lett. 2013;341:240-7 pubmed publisher
    ..We identified microphthalmia-associated transcription factor (MITF) as a direct target of miR-101...
  73. Hallsson J, Haflidadóttir B, Schepsky A, Arnheiter H, Steingrimsson E. Evolutionary sequence comparison of the Mitf gene reveals novel conserved domains. Pigment Cell Res. 2007;20:185-200 pubmed
    The microphthalmia-associated transcription factor (MITF) is a member of the MYC family of basic helix-loop-helix leucine zipper transcription factors...
  74. Chen J, Yang S, Liu J, Han B, Wang G, Zhang X, et al. [Mutation screening of MITF gene in patients with Waardenburg syndrome type 2]. Yi Chuan. 2008;30:433-8 pubmed
    ..MITF (microphthalmia associated transcription factor)is a basic-helix-loop-helix-luecine zipper (bHLHZip) factor which regulates expression of ..
  75. Takeda K, Takemoto C, Kobayashi I, Watanabe A, Nobukuni Y, Fisher D, et al. Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance. Hum Mol Genet. 2000;9:125-32 pubmed
    b>MITF (microphthalmia-associated transcription factor) is a basic-helix-loop-helix-leucine zipper (bHLHZip) factor which regulates expression of tyrosinase and other melanocytic genes via a CATGTG promoter sequence, and is involved in ..
  76. Takeda K, Yasumoto K, Kawaguchi N, Udono T, Watanabe K, Saito H, et al. Mitf-D, a newly identified isoform, expressed in the retinal pigment epithelium and monocyte-lineage cells affected by Mitf mutations. Biochim Biophys Acta. 2002;1574:15-23 pubmed
    Microphthalmia-associated transcription factor (Mitf) regulates the differentiation of melanocytes, optic cup-derived retinal pigment epithelium (RPE), and some types of bone marrow-derived cells...
  77. Wang Y, Radfar S, Liu S, Riker A, Khong H. Mitf-Mdel, a novel melanocyte/melanoma-specific isoform of microphthalmia-associated transcription factor-M, as a candidate biomarker for melanoma. BMC Med. 2010;8:14 pubmed publisher
    ..Full length MITF-M and its splice variant cDNA were cloned from human melanoma cell line 624 mel by reverse transcription polymerase ..
  78. Yasumoto K, Takeda K, Saito H, Watanabe K, Takahashi K, Shibahara S. Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling. EMBO J. 2002;21:2703-14 pubmed
    ..between the basic helix-loop-helix and leucine-zipper region of microphthalmia-associated transcription factor (MITF) and LEF-1...
  79. Levy C, Fisher D. Dual roles of lineage restricted transcription factors: the case of MITF in melanocytes. Transcription. 2011;2:19-22 pubmed publisher
    Microphthalmia-associated Transcription Factor, MITF, is a master regulator of melanocyte development, differentiation, migration, and survival...
  80. Anghel S, Correa Rocha R, Correa Rochal R, Budinska E, Boligan K, Boliganl K, et al. Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF. Pigment Cell Melanoma Res. 2012;25:482-7 pubmed publisher
    ..We demonstrate that BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype...
  81. Goodall J, Carreira S, Denat L, Kobi D, Davidson I, Nuciforo P, et al. Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. Cancer Res. 2008;68:7788-94 pubmed publisher
    ..In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) controls survival, differentiation, proliferation, and migration/metastasis...
  82. Hartman M, Talar B, Noman M, Gajos Michniewicz A, Chouaib S, Czyz M. Gene expression profiling identifies microphthalmia-associated transcription factor (MITF) and Dickkopf-1 (DKK1) as regulators of microenvironment-driven alterations in melanoma phenotype. PLoS ONE. 2014;9:e95157 pubmed publisher
    ..Higher expression levels of MITF-dependent genes that are responsible for differentiation, e.g., TYR and MLANA, and stemness-related genes, e.g...
  83. Davis I, Kim J, Ozsolak F, Widlund H, Rozenblatt Rosen O, Granter S, et al. Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer Cell. 2006;9:473-84 pubmed
    ..We show that EWS-ATF1 occupies the MITF promoter, mimicking melanocyte-stimulating hormone (MSH) signaling to induce expression of MITF, the melanocytic ..
  84. Yasumoto K, Yokoyama K, Takahashi K, Tomita Y, Shibahara S. Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes. J Biol Chem. 1997;272:503-9 pubmed
    ..a CATGTG motif, which was shown here to be bound in vitro by microphthalmia-associated transcription factor (MITF)...
  85. Terragni J, Nayak G, Banerjee S, Medrano J, Graham J, Brennan J, et al. The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 signaling. J Biol Chem. 2011;286:36215-27 pubmed publisher
    ..Inhibition of PI 3-kinase led to a loss of Max/Mnt binding and transcriptional induction by MITF and USF1, as well as FoxO...