Gene Symbol: MIRLET7D
Description: microRNA let-7d
Alias: LET7D, MIRNLET7D, hsa-let-7d, let-7d
Species: human
Products:     MIRLET7D

Top Publications

  1. Min H, Fan S, Song S, Zhuang Y, Li H, Wu Y, et al. Plasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis. Diagn Pathol. 2016;11:135 pubmed
    ..In conclusion, miR-25-3p and let-7d-5p in plasma were differentially expressed between AE-IPF and S-IPF. A combination of these two miRNAs may be a potential biomarker for AE-IPF from IPF. ..
  2. Chang C, Hsu C, Chang C, Tsai L, Chang Y, Lu S, et al. Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer. Oncol Rep. 2011;26:1003-10 pubmed publisher
    ..In sum, these results show that let-7d negatively modulates EMT expression and also plays a role in regulating chemo-resistant ability in oral cancer. ..
  3. Sun H, Ding C, Zhang H, Gao J. Let?7 miRNAs sensitize breast cancer stem cells to radiation?induced repression through inhibition of the cyclin D1/Akt1/Wnt1 signaling pathway. Mol Med Rep. 2016;14:3285-92 pubmed publisher
    ..Let?7d is suggested to be a promising therapeutic agent in the treatment of TNBC by targeting CSCs and sensitizing tumors to radiotherapy via inhibition of cyclin D1/Akt1/Wnt1 signaling. ..
  4. Su B, Zhao W, Shi B, Zhang Z, Yu X, Xie F, et al. Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7. Mol Cancer. 2014;13:206 pubmed publisher
    ..These results suggest that let-7d may suppress RCC growth, metastasis, and tumor macrophage infiltration at least partially through targeting COL3A1 and CCL7. ..
  5. Yan Y, Wu L, Zhang J, Wang S, Wang W, Dong J, et al. Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population. Endocr J. 2015;62:887-96 pubmed publisher
    ..In conclusion, our study found that let-7 related genetic variation is associated with MetS and may contribute to the susceptibility of MetS. Larger, prospective studies are warranted to validate our findings. ..
  6. Fedorko M, Juracek J, Staník M, Svoboda M, Poprach A, Buchler T, et al. Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. Biochem Med (Zagreb). 2017;27:411-417 pubmed publisher
  7. Wu L, Peng M, Yu M, Zhao Q, Li C, Jin Y, et al. Circulating MicroRNA Let-7d in Attention-Deficit/Hyperactivity Disorder. Neuromolecular Med. 2015;17:137-46 pubmed publisher
    ..05) than those with high level of circulating miRNA let-7d. Our data demonstrated that miRNA let-7d was elevated in the serum of ADHD subjects, which might be a novel, useful molecule signature for ADHD. ..
  8. Tunca B, Tezcan G, Cecener G, Egeli U, Ak S, Malyer H, et al. Olea europaea leaf extract alters microRNA expression in human glioblastoma cells. J Cancer Res Clin Oncol. 2012;138:1831-44 pubmed publisher
    ..The present study aimed to evaluate whether Olea europaea leaf extract (OLE) has an anticancer effect and modulates miRNA expression in GBM...
  9. Di Fiore R, Drago Ferrante R, Pentimalli F, Di Marzo D, Forte I, Carlisi D, et al. Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells. J Cell Physiol. 2016;231:1832-41 pubmed publisher
    ..J. Cell. Physiol. 231: 1832-1841, 2016. © 2015 Wiley Periodicals, Inc. ..

More Information


  1. Cho S, Mutlu L, Grechukhina O, Taylor H. Circulating microRNAs as potential biomarkers for endometriosis. Fertil Steril. 2015;103:1252-60.e1 pubmed publisher
    ..The combination of serum let-7b, 7d, and 7f levels during the proliferative phase may serve as a diagnostic marker for endometriosis. ..
  2. Lee Y, Dutta A. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev. 2007;21:1025-30 pubmed
  3. Liang H, Liu S, Chen Y, Bai X, Liu L, Dong Y, et al. miR-26a suppresses EMT by disrupting the Lin28B/let-7d axis: potential cross-talks among miRNAs in IPF. J Mol Med (Berl). 2016;94:655-65 pubmed publisher
    ..Lin28B is one of the targets of microRNA-26a. miR-26a enhances the expression of let-7d via targeting regulation of Lin28B. A regulatory network among miRNAs involved in the progression of IPF. ..
  4. Wang Z, Lin S, Zhang J, Xu Z, Xiang Y, Yao H, et al. Loss of MYC and E-box3 binding contributes to defective MYC-mediated transcriptional suppression of human MC-let-7a-1~let-7d in glioblastoma. Oncotarget. 2016;7:56266-56278 pubmed publisher
    ..Understanding the molecular mechanisms of their regulations will provide new insight and have important implications in the therapeutics of GBM as well as other cancers. ..
  5. Lamperska K, Kolenda T, Teresiak A, Kowalik A, Kruszyna Mochalska M, Jackowiak W, et al. Different levels of let-7d expression modulate response of FaDu cells to irradiation and chemotherapeutics. PLoS ONE. 2017;12:e0180265 pubmed publisher
    ..Only two of the generated models (A and C) were radiosensitive (p = 0.0002). the above results indicated that the level of let-7d expression is an important factor for cell response to irradiation and chemotherapeutics. ..
  6. Leinders M, Doppler K, Klein T, Deckart M, Rittner H, Sommer C, et al. Increased cutaneous miR-let-7d expression correlates with small nerve fiber pathology in patients with fibromyalgia syndrome. Pain. 2016;157:2493-2503 pubmed
    ..Our study gives further evidence of small nerve fiber pathology in FMS subgroups and provides a missing link in the pathomechanism that may lead to small fiber loss in subgroups of patients with FMS. ..
  7. Boyerinas B, Park S, Murmann A, Gwin K, Montag A, Zillhardt M, et al. Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1. Int J Cancer. 2012;130:1787-97 pubmed publisher
    ..Our data point at IMP-1 and MDR1 as indicators for response to therapy, and at IMP-1 as a novel therapeutic target for overcoming multidrug resistance of ovarian cancer. ..
  8. Andolfo I, De Falco L, Asci R, Russo R, Colucci S, Gorrese M, et al. Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells. Haematologica. 2010;95:1244-52 pubmed publisher
    ..DMT1-IRE might be the major DMT1 isoform expressed in erythroid cells, although its regulation pathways are still unknown...