Gene Symbol: MIR7-2
Description: microRNA 7-2
Alias: MIRN7-2, hsa-mir-7-2, mir-7-2
Species: human
Products:     MIR7-2

Top Publications

  1. Chang Y, Zhou P, Wei L, Li W, Ji Z, Fang Y, et al. MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway. Oncotarget. 2015;6:24017-31 pubmed
    ..This study identifies miR-7 as a suppressor of PCSCs' stemness and implicates its potential application for PCa therapy. ..
  2. Liu Z, Liu Y, Li L, Xu Z, Bi B, Wang Y, et al. MiR-7-5p is frequently downregulated in glioblastoma microvasculature and inhibits vascular endothelial cell proliferation by targeting RAF1. Tumour Biol. 2014;35:10177-84 pubmed publisher
    ..It may serve as a guide for the antitumor angiogenesis drug development. ..
  3. Qin K, Zhong X, Wang D. MicroRNA-7-5p regulates human alveolar epithelial sodium channels by targeting the mTORC2/SGK-1 signaling pathway. Exp Lung Res. 2016;42:237-44 pubmed publisher
    ..The inhibition of miRNA-7-5p can enhance the expression of ENaC, which may provide a new target for the treatment of ARDS. ..
  4. Xie J, Chen M, Zhou J, Mo M, Zhu L, Liu Y, et al. miR-7 inhibits the invasion and metastasis of gastric cancer cells by suppressing epidermal growth factor receptor expression. Oncol Rep. 2014;31:1715-22 pubmed publisher
    ..The data from the present study demonstrated that reduced miR-7 expression contributes to gastric cancer development and progression. Further study will investigate miR-7 in the regulation of EGFR expression in vitro and in vivo. ..
  5. Liu Z, Jiang Z, Huang J, Huang S, Li Y, Yu S, et al. miR-7 inhibits glioblastoma growth by simultaneously interfering with the PI3K/ATK and Raf/MEK/ERK pathways. Int J Oncol. 2014;44:1571-80 pubmed publisher
    ..We conclude that miR-7 is a potential tumor suppressor in glioblastoma that acts by targeting multiple oncogenes related to the downstream pathway of EGFR and may serve as a novel therapeutic target for malignant gliomas. ..
  6. Horsham J, Ganda C, Kalinowski F, Brown R, Epis M, Leedman P. MicroRNA-7: A miRNA with expanding roles in development and disease. Int J Biochem Cell Biol. 2015;69:215-24 pubmed publisher
    ..The more we learn about miR-7, the more we realise the complexity of its regulation and potential functional application both from a biomarker and therapeutic perspective. ..
  7. Wang F, Qiang Y, Zhu L, Jiang Y, Wang Y, Shao X, et al. MicroRNA-7 downregulates the oncogene VDAC1 to influence hepatocellular carcinoma proliferation and metastasis. Tumour Biol. 2016;37:10235-46 pubmed publisher
    ..Our study suggested that miR-7 suppressed the expression of VDAC1. VDAC1 plays an important role in tumor progression and may be used as a potential role in the prognosis of HCC patients. ..
  8. Correa Medina M, Bravo Egana V, Rosero S, Ricordi C, Edlund H, Diez J, et al. MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas. Gene Expr Patterns. 2009;9:193-9 pubmed publisher
  9. Shi Y, Luo X, Li P, Tan J, Wang X, Xiang T, et al. miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGγ. Cancer Lett. 2015;358:27-36 pubmed publisher
    ..Our data indicate that miR-7-5p has a critical function through blocking REGγ in breast cancer cells. ..

More Information


  1. Xu L, Wen Z, Zhou Y, Liu Z, Li Q, Fei G, et al. MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway. Mol Biol Cell. 2013;24:42-55 pubmed publisher
  2. Hara K, Miyazaki T, Yokobori T, Yoshida T, Kumakura Y, Honjyo H, et al. Significance and Function of MicroRNA-7 in Oesophageal Squamous Cell Carcinoma. Anticancer Res. 2017;37:1043-1048 pubmed
    ..In vitro assays showed miR-7 precursor treatment suppressed the proliferation of ESCC cells. miR-7 might be a promising prognostic marker and therapeutic target in ESCC. ..
  3. Ma J, Fang B, Zeng F, Pang H, Zhang J, Shi Y, et al. Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells. Toxicol Lett. 2014;231:82-91 pubmed publisher
    ..These findings demonstrated that targeting miR-7 by curcumin could be a novel strategy for the treatment of pancreatic cancer. ..
  4. Midgley A, Morris G, Phillips A, Steadman R. 17β-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-γ/STAT1-dependent miR-7 upregulation. Aging Cell. 2016;15:531-41 pubmed publisher
    ..The modulation of fibroblast functions and ultimately wound healing by miR-7 activators or inhibitors could provide realistic targets for the restoration of chronic wound healing capabilities in the elderly. ..
  5. Gu D, Jiang M, Mei Z, Dai J, Dai C, Fang C, et al. microRNA-7 impairs autophagy-derived pools of glucose to suppress pancreatic cancer progression. Cancer Lett. 2017;400:69-78 pubmed publisher
    ..Hence, miR-7 might be a potential therapeutic target in pancreatic cancer. ..
  6. Li Y, Wen L, Wei X, Wang Q, Xu L, Zhang H, et al. Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4. Oncol Rep. 2016;36:1569-75 pubmed publisher
  7. Zhang X, Guo J, Ai S, Hu Y, Sun Q, Xu Q, et al. Mutation analysis of microRNA-7 gene in Chinese patients with Parkinson's disease. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012;37:1189-92 pubmed publisher
    ..We analyzed miR-7 variants in 225 PD patients from Chinese Han group by DNA sequence. None of the patients had miR-7 variants. MiR-7 variation is not associated with PD in Chinese patients. ..
  8. Chaudhuri A, Kabaria S, Choi D, Mouradian M, Junn E. MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death. J Biol Chem. 2015;290:12425-34 pubmed publisher
    ..This protective effect of microRNA-7 could be exploited to correct the defects in oxidative phosphorylation in Parkinson disease. ..
  9. Hu Y, Li D, Wu A, Qiu X, Di W, Huang L, et al. TWEAK-stimulated macrophages inhibit metastasis of epithelial ovarian cancer via exosomal shuttling of microRNA. Cancer Lett. 2017;393:60-67 pubmed publisher
    ..These findings provide a novel model in which TMs inhibit the metastasis of EOC cells via shuttling of exosomal miR-7 to EOC cells, thereby inhibiting the EGFR/AKT/ERK1/2 pathway. ..
  10. Kim S, Chen Z, Essani A, Elshabrawy H, Volin M, Volkov S, et al. Identification of a Novel Toll-like Receptor 7 Endogenous Ligand in Rheumatoid Arthritis Synovial Fluid That Can Provoke Arthritic Joint Inflammation. Arthritis Rheumatol. 2016;68:1099-110 pubmed publisher
    ..The results of this study underscore the importance of miR-let-7b ligation to TLR-7 in the joint during the effector phase of RA. ..
  11. Shaer A, Azarpira N, Karimi M, Soleimani M, Dehghan S. Differentiation of Human-Induced Pluripotent Stem Cells Into Insulin-Producing Clusters by MicroRNA-7. Exp Clin Transplant. 2016;14:555-563 pubmed publisher
    ..Chemical transfection with microRNA-7 can differentiate human induced pluripotent stem cells into functional isletlike cell clusters in a short time. ..
  12. Visani M, de Biase D, Marucci G, Cerasoli S, Nigrisoli E, Bacchi Reggiani M, et al. Expression of 19 microRNAs in glioblastoma and comparison with other brain neoplasia of grades I-III. Mol Oncol. 2014;8:417-30 pubmed publisher
    ..This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs. ..
  13. Shahab S, Matyunina L, Hill C, Wang L, Mezencev R, Walker L, et al. The effects of MicroRNA transfections on global patterns of gene expression in ovarian cancer cells are functionally coordinated. BMC Med Genomics. 2012;5:33 pubmed publisher
    ..The functionally coordinated patterns of gene expression displayed by different families of miRNAs have the potential to provide clinicians with a strategy to treat cancers from a systems rather than a single gene perspective. ..
  14. Luo J, Cai Q, Wang W, Huang H, Zeng H, He W, et al. A microRNA-7 binding site polymorphism in HOXB5 leads to differential gene expression in bladder cancer. PLoS ONE. 2012;7:e40127 pubmed publisher
    ..HOXB5 is overexpressed in bladder cancer. A miRNA-binding SNP (1010A/G) located within 3'-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer. ..
  15. Kabaria S, Choi D, Chaudhuri A, Jain M, Li H, Junn E. MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression. Free Radic Biol Med. 2015;89:548-56 pubmed publisher
    ..These findings point to a new mechanism by which miR-7 exerts cytoprotective effects by regulating the Nrf2 pathway. ..
  16. Liu H, Wu X, Huang J, Peng J, Guo L. miR-7 modulates chemoresistance of small cell lung cancer by repressing MRP1/ABCC1. Int J Exp Pathol. 2015;96:240-7 pubmed publisher
    ..Our data suggested that miR-7 mediated SCLC chemoresistance by repressing MRP1/ABCC1 and may be a prognostic predictor and potential therapeutic target in human SCLC. ..
  17. Wang B, Sun F, Dong N, Sun Z, Diao Y, Zheng C, et al. MicroRNA-7 directly targets insulin-like growth factor 1 receptor to inhibit cellular growth and glucose metabolism in gliomas. Diagn Pathol. 2014;9:211 pubmed publisher
    ..Therefore, miR-7 is a promising molecular drug for glioma treatment. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_211. ..
  18. Yu Z, Ni L, Chen D, Zhang Q, Su Z, Wang Y, et al. Identification of miR-7 as an oncogene in renal cell carcinoma. J Mol Histol. 2013;44:669-77 pubmed publisher
    ..Further researches should be conducted to explore the roles and target genes of miR-7 in RCC and other cancers. ..
  19. Giles K, Brown R, Epis M, Kalinowski F, Leedman P. miRNA-7-5p inhibits melanoma cell migration and invasion. Biochem Biophys Res Commun. 2013;430:706-10 pubmed publisher
    ..Thus, miR-7-5p may represent a novel tumor suppressor miRNA in melanoma, acting at least in part via its inhibition of IRS-2 expression and oncogenic Akt signaling. ..