Gene Symbol: MIR615
Description: microRNA 615
Alias: MIRN615, hsa-mir-615
Song L, Zhang W, Chang Z, Pan Y, Zong H, Fan Q, et al
. PU.1 Is Identified as a Novel Metastasis Suppressor in Hepatocellular Carcinoma Regulating the miR-615-5p/IGF2 Axis. Asian Pac J Cancer Prev. 2015;16:3667-71 pubmed
..1 inhibits invasion of human HCC through promoting miR-615-5p and suppressing IGF2. These findings improve our understanding of PU.1 regulatory roles and provided a potential target for metastatic HCC diagnosis and therapy. ..
Wu X, Deng L, Tang D, Ying G, Yao X, Liu F, et al
. miR-615-5p prevents proliferation and migration through negatively regulating serine hydromethyltransferase 2 (SHMT2) in hepatocellular carcinoma. Tumour Biol. 2016;37:6813-21 pubmed publisher
..Together, our results for the first time showed that miR-615-5p prevents proliferation and migration through negatively regulating SHMT2 in HCC. ..
Jiang A, Zhang S, Li Z, Liang R, Ren S, Li J, et al
. miR-615-3p promotes the phagocytic capacity of splenic macrophages by targeting ligand-dependent nuclear receptor corepressor in cirrhosis-related portal hypertension. Exp Biol Med (Maywood). 2011;236:672-80 pubmed publisher
..This finding might be useful in the study of hypersplenism and other macrophage-associated diseases. ..
Sun Y, Zhang T, Wang C, Jin X, Jia C, Yu S, et al
. MiRNA-615-5p functions as a tumor suppressor in pancreatic ductal adenocarcinoma by targeting AKT2. PLoS ONE. 2015;10:e0119783 pubmed publisher
..These results show that miR-615-5p inhibits pancreatic cancer cell proliferation, migration, and invasion by targeting AKT2. The data implicate miR-615-5p in the prognosis and treatment of PDAC. ..
Jiang Y, Zhang Y, Li F, Du X, Zhang J. CDX2 inhibits pancreatic adenocarcinoma cell proliferation via promoting tumor suppressor miR-615-5p. Tumour Biol. 2016;37:1041-9 pubmed publisher
..Collectively, CDX2 inhibited pancreatic adenocarcinoma cell proliferation via promoting tumor suppressor miR-615-5p. Our findings suggested a potential molecular target for pancreatic adenocarcinoma therapy. ..
El Tayebi H, Hosny K, Esmat G, Breuhahn K, Abdelaziz A. miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma. FEBS Lett. 2012;586:3309-16 pubmed publisher
..miR-615-5p acts as tumor-suppressor in HCC through targeting IGF-II. ..
Gao W, Gu Y, Li Z, Cai H, Peng Q, Tu M, et al
. miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma. Oncogene. 2015;34:1629-40 pubmed publisher
..These data demonstrate a novel and important role of miR-615-5p as a tumor suppressor in PDAC. ..
Chen Z, Wang X, Liu R, Chen L, Yi J, Qi B, et al
. KDM4B-mediated epigenetic silencing of miRNA-615-5p augments RAB24 to facilitate malignancy of hepatoma cells. Oncotarget. 2017;8:17712-17725 pubmed publisher
Yin J, Zhuang G, Zhu Y, Hu X, Zhao H, Zhang R, et al
. MiR-615-3p inhibits the osteogenic differentiation of human lumbar ligamentum flavum cells via suppression of osteogenic regulators GDF5 and FOXO1. Cell Biol Int. 2017;41:779-786 pubmed publisher
..In conclusion, miR-615-3p negatively regulates the osteogenic differentiation of hLF cells through post-transcriptionally suppressing osteogenic regulators GDF5 and FOXO1. It can be regarded as a potential target for human OLF therapy. ..