Gene Symbol: MIR582
Description: microRNA 582
Alias: MIRN582, hsa-mir-582
Species: human
Products:     MIR582

Top Publications

  1. Lam L, Lu X, Zhang H, Lesniewski R, Rosenberg S, Semizarov D. A microRNA screen to identify modulators of sensitivity to BCL2 inhibitor ABT-263 (navitoclax). Mol Cancer Ther. 2010;9:2943-50 pubmed publisher
    ..Finally, because sensitizing miRNA expression is lower in tumors compared with normal tissues, our data can facilitate the design of miRNA replacement therapies to increase sensitivity to BCL2 antagonists. ..
  2. Nicolas G, Wallon D, Goupil C, Richard A, Pottier C, Dorval V, et al. Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy. Eur J Hum Genet. 2016;24:92-8 pubmed publisher
    ..These results identify APP 3'UTR sequence variants as genetic determinants of Aβ-CAA. ..
  3. Zhang Y, Huang W, Ran Y, Xiong Y, Zhong Z, Fan X, et al. miR-582-5p inhibits proliferation of hepatocellular carcinoma by targeting CDK1 and AKT3. Tumour Biol. 2015;36:8309-16 pubmed publisher
    ..Further studies showed that miR-582-5p regulated the progression of HCC through directly inhibiting the expression of CDK1 and AKT3, and indirectly inhibiting the expression of cyclinD1. ..
  4. Su M, Tsai P, Tsai H, Chen Y, Kuo P. miR-346 and miR-582-3p-regulated EG-VEGF expression and trophoblast invasion via matrix metalloproteinases 2 and 9. Biofactors. 2017;43:210-219 pubmed publisher
    ..2016 BioFactors, 43(2):210-219, 2017. ..
  5. Liu Y, Jiang J, Wang X, Zhai F, Cheng X. miR-582-5p is upregulated in patients with active tuberculosis and inhibits apoptosis of monocytes by targeting FOXO1. PLoS ONE. 2013;8:e78381 pubmed publisher
    ..In conclusion, miR-582-5p inhibited apoptosis of monocytes by down-regulating FOXO1 expression and might play an important role in regulating anti-M. tuberculosis directed immune responses. ..
  6. Zhang X, Zhang Y, Yang J, Li S, Chen J. Upregulation of miR-582-5p inhibits cell proliferation, cell cycle progression and invasion by targeting Rab27a in human colorectal carcinoma. Cancer Gene Ther. 2015;22:475-80 pubmed publisher
    ..Our data suggest that miR-582-5p may function as a tumor suppressor in the development of CRC by targeting Rab27a, indicating a novel therapeutic strategy for patients with CRC. ..
  7. Fang L, Cai J, Chen B, Wu S, Li R, Xu X, et al. Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling. Nat Commun. 2015;6:8640 pubmed publisher
    ..These findings suggest that miR-582-3p mediates the constitutive activation of Wnt/β-catenin signalling, likely serving as a potential therapeutic target for NSCLC. ..
  8. Shu Z, Chen L, Ding D. miR-582-5P induces colorectal cancer cell proliferation by targeting adenomatous polyposis coli. World J Surg Oncol. 2016;14:239 pubmed publisher
    ..Our findings suggest that miR-582-5P plays an important role in the progression of CRC by inducing proliferation and may identify new targets for anti-cancer treatment. ..
  9. Song B, Long Y, Liu D, Zhang W, Liu C. MicroRNA-582 promotes tumorigenesis by targeting phosphatase and tensin homologue in colorectal cancer. Int J Mol Med. 2017;40:867-874 pubmed publisher
    ..Our findings therefore indicate that miR‑582 promotes CRC progression by decreasing PTEN expression. These findings may also imply that miR‑582 may be a target for therapeutic intervention in patients with CRC. ..

More Information


  1. Tsai P, Li S, Chen W, Tsai H, Su M. Differential miR-346 and miR-582-3p Expression in Association with Selected Maternal and Fetal Complications. Int J Mol Sci. 2017;18: pubmed publisher
    ..Their differential expression in maternal blood, umbilical cord blood and placenta could be potential biomarkers or therapeutic targets for adverse obstetric outcomes. ..
  2. Qin J, Liang H, Shi D, Dai J, Xu Z, Chen D, et al. A panel of microRNAs as a new biomarkers for the detection of deep vein thrombosis. J Thromb Thrombolysis. 2015;39:215-21 pubmed publisher
    ..And this is the first study suggesting that serum microNRAs might be used as biomarkers for deep vein thrombosis. ..