Gene Symbol: MIR509-1
Description: microRNA 509-1
Alias: MIRN509, MIRN509-1, hsa-mir-509
Novotny G, Nielsen J, Sonne S, Skakkebaek N, Rajpert De Meyts E, Leffers H. Analysis of gene expression in normal and neoplastic human testis: new roles of RNA. Int J Androl. 2007;30:316-26; discussion 326-7 pubmed
..Additionally, we show through cloning the presence of both known and new miRNAs in the testis emphasizing the necessity for following up mRNA expression data by investigating expression at the protein level. ..
Ren Z, Nong X, Lv Y, Sun H, An P, Wang F, et al
. Mir-509-5p joins the Mdm2/p53 feedback loop and regulates cancer cell growth. Cell Death Dis. 2014;5:e1387 pubmed publisher
..These results suggest that miR-509-5p is a new regulator of Mdm2/p53 pathway and may play a key role in cancer development. ..
Ma N, Zhang W, Qiao C, Luo H, Zhang X, Liu D, et al
. The Tumor Suppressive Role of MiRNA-509-5p by Targeting FOXM1 in Non-Small Cell Lung Cancer. Cell Physiol Biochem. 2016;38:1435-46 pubmed publisher
..Collectively, these findings provide further evidence that miR-509-5p may be considered as a novel and potential target for the diagnosis, prognosis and treatment of NSCLC. ..
Pandey R, Yang Y, Jackson L, Ahmed R. MicroRNAs regulating meis1 expression and inducing cardiomyocyte proliferation. Cardiovasc Regen Med. 2016;3: pubmed
..Further investigating of the mechanism of action of these miRNAs can identify other treatment options for abnormalities associated with the lack of cardiac regeneration post myocardial injury. ..
Zhang W, Pan Z, Yang Q, Zheng X. Tumor suppressive miR-509-5p contributes to cell migration, proliferation and antiapoptosis in renal cell carcinoma. Ir J Med Sci. 2013;182:621-7 pubmed publisher
..In addition, miR-509-5p expression was significantly lower in RCC patient plasma compared to that in normal individuals. ..
Wang P, Deng Y, Fu X. MiR-509-5p suppresses the proliferation, migration, and invasion of non-small cell lung cancer by targeting YWHAG. Biochem Biophys Res Commun. 2017;482:935-941 pubmed publisher
Tian X, Luo Y, He P, Li J, Ma Z, An Y. Inhibition of invasion and migration of prostate cancer cells by miRNA-509-5p via targeting MDM2. Genet Mol Res. 2017;16: pubmed publisher
..Therefore, miRNA-509-5p could be used as a novel therapeutic agent in the treatment of prostate cancer. ..
Xing F, Sharma S, Liu Y, Mo Y, Wu K, Zhang Y, et al
. miR-509 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF-Î±. Oncogene. 2015;34:4890-900 pubmed publisher
Zhang G, Liu Z, Han Y, Wang X, Yang Z. Overexpression of miR-509 Increases Apoptosis and Inhibits Invasion via Suppression of Tumor Necrosis Factor-? in Triple-Negative Breast Cancer Hs578T Cells. Oncol Res. 2016;24:233-8 pubmed publisher
..Collectively, these data suggest that miR-509 could reverse the malignant phenotype of TNBC cells, probably by suppressing TNF-?. ..