Gene Symbol: MIR498
Description: microRNA 498
Alias: MIRN498, hsa-mir-498
Species: human

Top Publications

  1. Kasiappan R, Shen Z, Tse A, Jinwal U, Tang J, Lungchukiet P, et al. 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498. J Biol Chem. 2012;287:41297-309 pubmed publisher
    ..Taken together, our studies define a novel mechanism of telomerase regulation by small non-coding RNAs and identify miR-498 as an important mediator for the anti-tumor activity of 1,25(OH)(2)D(3). ..
  2. Kasiappan R, Sun Y, Lungchukiet P, Quarni W, Zhang X, Bai W. Vitamin D suppresses leptin stimulation of cancer growth through microRNA. Cancer Res. 2014;74:6194-204 pubmed publisher
    ..The studies suggest that miR-498-mediated hTERT downregulation is a key event mediating the anti-leptin activity of 1,25(OH)2D3 in estrogen-sensitive tumors in women. ..
  3. Liu R, Liu F, Li L, Sun M, Chen K. MiR-498 regulated FOXO3 expression and inhibited the proliferation of human ovarian cancer cells. Biomed Pharmacother. 2015;72:52-7 pubmed publisher
    ..Thus, our findings suggested that miR-498 acted as a new tumor suppressor by targeting the FOXO3 gene and inhibiting cell proliferation of ovarian cancer. ..
  4. Matamala N, Vargas M, González Cámpora R, Arias J, Menéndez P, Andrés León E, et al. MicroRNA deregulation in triple negative breast cancer reveals a role of miR-498 in regulating BRCA1 expression. Oncotarget. 2016;7:20068-79 pubmed publisher
    ..Our results indicate that miR-498 regulates BRCA1 expression in breast cancer and its overexpression could contribute to the pathogenesis of sporadic TNBC via BRCA1 downregulation. ..
  5. Wu B, Wang D, Bai W, Zhang F, Zhao X, Yi Y, et al. An integrative framework to identify cell death-related microRNAs in esophageal squamous cell carcinoma. Oncotarget. 2016;7:56758-56766 pubmed publisher
    ..Follow-up experimental verification of 7 miRNAs indicated at least 3 miRNAs (MIR20b, MIR498 and MIR196) were involved in both apoptosis and autophagy processes...
  6. Islam F, Gopalan V, Law S, Tang J, Chan K, Lam A. MiR-498 in esophageal squamous cell carcinoma: clinicopathological impacts and functional interactions. Hum Pathol. 2017;62:141-151 pubmed publisher
    ..The changes in miR-498 expression may have impacts on the clinical pathological parameters of ESCC as well as in the management of the patients with ESCC. ..
  7. Yan Q, Li W, Tang Q, Yao S, Lv Z, Feng N, et al. Cellular microRNAs 498 and 320d regulate herpes simplex virus 1 induction of Kaposi's sarcoma-associated herpesvirus lytic replication by targeting RTA. PLoS ONE. 2013;8:e55832 pubmed publisher
  8. Gopalan V, Smith R, Lam A. Downregulation of microRNA-498 in colorectal cancers and its cellular effects. Exp Cell Res. 2015;330:423-8 pubmed publisher
  9. Wang M, Zhang Q, Wang J, Zhai Y. MicroRNA-498 is downregulated in non-small cell lung cancer and correlates with tumor progression. J Cancer Res Ther. 2015;11 Suppl 1:C107-11 pubmed publisher
    ..Our data indicated that miR-498 is downregulated and correlated with tumor progression, which might be a putitive therapeutic target in NSCLC treatment. ..

More Information


  1. Cong J, Liu R, Wang X, Wang J, Wang H, Hou J. Low miR-498 expression levels are associated with poor prognosis in ovarian cancer. Eur Rev Med Pharmacol Sci. 2015;19:4762-5 pubmed
    ..Decreased expression levels of miR-498 are associated with worse overall survival and poor prognosis in patients with ovarian cancer, highlighting potential usefulness of this miR for prognosis in patients with ovarian cancer. ..