Gene Symbol: MIR451A
Description: microRNA 451a
Alias: MIR451, MIRN451, hsa-mir-451, hsa-mir-451a
Species: human

Top Publications

  1. Bandres E, Bitarte N, Arias F, Agorreta J, Fortes P, Agirre X, et al. microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells. Clin Cancer Res. 2009;15:2281-90 pubmed publisher
    ..These findings support the role of miR-451 as a regulator of cancer proliferation and open new perspectives for the development of effective therapies for chemoradioresistant cancers. ..
  2. Kovalchuk O, Filkowski J, Meservy J, Ilnytskyy Y, Tryndyak V, Chekhun V, et al. Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol Cancer Ther. 2008;7:2152-9 pubmed publisher
  3. Tian Y, Nan Y, Han L, Zhang A, Wang G, Jia Z, et al. MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma. Int J Oncol. 2012;40:1105-12 pubmed publisher
    ..We conclude that miR-451 represses glioma in vitro and in vivo, likely through targeting CAB39 directly and inhibiting the PI3K/AKT pathway indirectly. ..
  4. Wang R, Wang Z, Yang J, Pan X, De W, Chen L. MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14). Oncogene. 2011;30:2644-58 pubmed publisher
    ..Therefore, targeting with the miR-451/RAB14 interaction might serve as a novel therapeutic application to treat NSCLC patients. ..
  5. Godlewski J, Nowicki M, Bronisz A, Nuovo G, Palatini J, De Lay M, et al. MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol Cell. 2010;37:620-32 pubmed publisher
    ..Thus, miR-451 is a regulator of the LKB1/AMPK pathway, and this may represent a fundamental mechanism that contributes to cellular adaptation in response to altered energy availability. ..
  6. Nan Y, Han L, Zhang A, Wang G, Jia Z, Yang Y, et al. MiRNA-451 plays a role as tumor suppressor in human glioma cells. Brain Res. 2010;1359:14-21 pubmed publisher
    ..We propose an essential role for miR-451 as a tumor-suppressor of human glioma. ..
  7. Gao Z, Liu R, Liao J, Yang M, Pan E, Yin L, et al. Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis. Mol Med Rep. 2016;14:3805-13 pubmed publisher
    ..Therefore, the miR?144/451 cluster may serve an important role in the progression of esophageal carcinoma and may be considered as a biomarker for the detection of esophageal carcinoma at an early stage. ..
  8. Masaki S, Ohtsuka R, Abe Y, Muta K, Umemura T. Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis. Biochem Biophys Res Commun. 2007;364:509-14 pubmed
    ..These observations suggest that miR-155 and miR-451 are key molecules for normal erythroid differentiation, and that quantitative assays of the two miRNAs may be a relevant method for analyzing pathological erythropoiesis. ..
  9. Yamada H, Itoh M, Hiratsuka I, Hashimoto S. Circulating microRNAs in autoimmune thyroid diseases. Clin Endocrinol (Oxf). 2014;81:276-81 pubmed publisher
    ..We revealed that different levels of serum miRNAs were associated with GD and HT, which may play a role in the pathogenesis of these diseases. ..

More Information


  1. Cheng D, Xu Y, Sun C, He Z. MicroRNA-451 sensitizes lung cancer cells to cisplatin through regulation of Mcl-1. Mol Cell Biochem. 2016;423:85-91 pubmed
  2. Bruchova Votavova H, Yoon D, Prchal J. miR-451 enhances erythroid differentiation in K562 cells. Leuk Lymphoma. 2010;51:686-93 pubmed publisher
    ..These data support the concept that aberrant expression of miRNAs may contribute to abnormal erythropoiesis such as that of PV. ..
  3. Guo R, Gu J, Zhang Z, Wang Y, Gu C. MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39. Biomed Res Int. 2017;2017:2381482 pubmed publisher
    ..Our findings improve our understanding of the function of miR-451 in the identification and therapy of pancreatic cancer. ..
  4. Liu S, Deng S, He Y, Ni G. miR-451 inhibits cell growth, migration and angiogenesis in human osteosarcoma via down-regulating IL 6R. Biochem Biophys Res Commun. 2017;482:987-993 pubmed publisher
    ..In conclusion, our data demonstrate that miR-451 may function as a potential suppressor of tumor growth, migration and angiogenesis in OS via down-regulating IL 6R, suggesting a promising therapeutic avenue for managing OS. ..
  5. Li X, Sanda T, Look A, Novina C, von Boehmer H. Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL. J Exp Med. 2011;208:663-75 pubmed publisher
    ..Thus, miR-451 and miR-709 function as potent suppressors of oncogenesis in NOTCH1-induced mouse T-ALL, and miR-451 influences MYC expression in human T-ALL bearing NOTCH1 mutations. ..
  6. Kohrs N, Kolodziej S, Kuvardina O, Herglotz J, Yillah J, Herkt S, et al. MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO. PLoS Genet. 2016;12:e1005946 pubmed publisher
    ..Thus RUNX1/ETO contributes to increased expression of miR451 target genes and interferes with normal gene expression during differentiation...
  7. Bitarte N, Bandres E, Boni V, Zarate R, Rodriguez J, Gonzalez Huarriz M, et al. MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells. Stem Cells. 2011;29:1661-71 pubmed publisher
    ..Our data suggest that miR-451 is a novel candidate to circumvent recurrence and drug resistance in colorectal cancer and could be used as a marker to predict response to irinotecan in patients with colon carcinoma. ..
  8. Nothnick W, Falcone T, Joshi N, Fazleabas A, Graham A. Serum miR-451a Levels Are Significantly Elevated in Women With Endometriosis and Recapitulated in Baboons ( Papio anubis) With Experimentally-Induced Disease. Reprod Sci. 2017;24:1195-1202 pubmed publisher
    ..MicroRNA-451a may serve as a serum diagnostic marker for endometriosis. ..
  9. Zhang J, Qin X, Sun Q, Guo H, Wu X, Xie F, et al. Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression. Oncogene. 2015;34:3283-95 pubmed publisher
    ..This discovery suggests that a PAX4-miR-144/451-ADAMs axis regulates human epithelial cancer metastasis, thus opening up therapeutic possibilities and predicting prognosis for those cancer types. ..
  10. Ren C, Chen H, Han C, Fu D, Wang D, Shen M. High expression of miR-16 and miR-451 predicating better prognosis in patients with gastric cancer. J Cancer Res Clin Oncol. 2016;142:2489-2496 pubmed
    ..Especially patients with miR-16 and miR-451 double high expression will predict better OS. MiR-16 and miR-451 may be used as novel makers to evaluate prognosis and provide a new treatment target in GC. ..
  11. Su R, Gong J, Chen M, Song L, Shen C, Zhang X, et al. c-Myc suppresses miR-451⊣YWTAZ/AKT axis via recruiting HDAC3 in acute myeloid leukemia. Oncotarget. 2016;7:77430-77443 pubmed publisher
    ..These results suggested that c-Myc⊣miR-451⊣YWHAZ/AKT cascade might play a crucial role during leukemogenesis, and reintroduction of miR-451 could be as a potential strategy for AML therapy. ..
  12. Xu K, Zhang Y, Han B, Bai Y, Xiong Y, Song Y, et al. Suppression subtractive hybridization identified differentially expressed genes in colorectal cancer: microRNA-451a as a novel colorectal cancer-related gene. Tumour Biol. 2017;39:1010428317705504 pubmed publisher
    ..MicroRNA-451a was demonstrated to be downregulated in colorectal cancer patient tissues whose target genes were analyzed and functions were predicted by suppression subtractive hybridization. ..
  13. Liu X, Zhang A, Xiang J, Lv Y, Zhang X. miR-451 acts as a suppressor of angiogenesis in hepatocellular carcinoma by targeting the IL-6R-STAT3 pathway. Oncol Rep. 2016;36:1385-92 pubmed publisher
    ..Accordingly, miR-451 may function as a potential suppressor of tumor angiogenesis in HCC by targeting IL-6R-STAT3-VEGF signaling, suggesting a promising therapeutic avenue for managing HCC. ..
  14. Zhu H, Zhang L, Xu J, Zhu C, Zhao H, Zhu Y, et al. AntogomiR-451 protects human gastric epithelial cells from ethanol via activating AMPK signaling. Biochem Biophys Res Commun. 2018;497:339-346 pubmed publisher
    ..Collectively, antagomiR-451 protects human GECs from ethanol via activating AMPK signaling. ..
  15. Gu X, Li J, Guo J, Li P, Zhang W. Influence of MiR-451 on Drug Resistances of Paclitaxel-Resistant Breast Cancer Cell Line. Med Sci Monit. 2015;21:3291-7 pubmed
  16. Zhu S, Huang Y, Su X. Mir-451 Correlates with Prognosis of Renal Cell Carcinoma Patients and Inhibits Cellular Proliferation of Renal Cell Carcinoma. Med Sci Monit. 2016;22:183-90 pubmed
    ..The targeted gene of miR-451 is PSMB8. MiR-451 acts as an anti-oncogene in RCC. Our data offer a new therapeutic target for further research. ..
  17. Tang Y, Wan W, Wang L, Ji S, Zhang J. microRNA-451 inhibited cell proliferation, migration and invasion through regulation of MIF in renal cell carcinoma. Int J Clin Exp Pathol. 2015;8:15611-21 pubmed
  18. Zeng T, Peng L, Chao C, Fu B, Wang G, Wang Y, et al. miR-451 inhibits invasion and proliferation of bladder cancer by regulating EMT. Int J Clin Exp Pathol. 2014;7:7653-62 pubmed
    ..In conclusion, miR451 should be a tumor-suppressing gene in bladder cancer...
  19. Chen M, Wei M, Han J, Wu X, Li C, Wang J, et al. MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer. Cell Signal. 2014;26:102-9 pubmed publisher
    ..Our results suggested that the over-expressed microRNA-451 in colon cancer cells might inhibit AMPK to activate mTORC1, which mediates FSCN1 expression and cancer cell progression. ..
  20. Wang H, Zhang G, Wu Z, Lu B, Yuan D, Li X, et al. MicoRNA-451 is a novel tumor suppressor via targeting c-myc in head and neck squamous cell carcinomas. J Cancer Res Ther. 2015;11 Suppl 2:C216-21 pubmed publisher
    ..Our findings identify miRNA-451 as a potential biomarker and suggest a key role of miRNA-451-c-myc pathway in HNSCC cell transformation, which could represent a novel therapeutic strategy in HNSCC treatment. ..
  21. He J, Xu Q, Jing Y, Agani F, Qian X, Carpenter R, et al. Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation. EMBO Rep. 2012;13:1116-22 pubmed publisher
    ..These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR-199a and miR-125b downregulation and DNA hypermethylation. ..
  22. Liu X, Zhang X, Xiang J, Lv Y, Shi J. miR-451: potential role as tumor suppressor of human hepatoma cell growth and invasion. Int J Oncol. 2014;45:739-45 pubmed publisher
    ..Thus, our research supports this promising therapeutic agent against hepatoma. ..
  23. Camkurt M, Acar Å, CoÅŸkun S, GüneÅŸ M, GüneÅŸ S, Yılmaz M, et al. Comparison of plasma MicroRNA levels in drug naive, first episode depressed patients and healthy controls. J Psychiatr Res. 2015;69:67-71 pubmed publisher
    ..Additionally, miR-451a could serve as a candidate biomarker for depression based on the acting mechanism of ketamine. Studies targeting miR-451a levels before and after treatment could be helpful. ..
  24. Wang Z, Lu H, Zhou Q, Yu S, Mao Y, Zhang H, et al. MiR-451 inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion in rheumatoid arthritis through mediating p38MAPK signaling pathway. Int J Clin Exp Pathol. 2015;8:14562-7 pubmed
    ..01), and IL-6 (487 ± 84 pg/ml vs 257 ± 92 pg/ml, P < 0.01). The results proved that miR-451 can down-regulate p38 MAPK protein expression, and reduce synovial fibroblasts proliferation and cytokine expression level. ..
  25. Minna E, Romeo P, Dugo M, De Cecco L, Todoerti K, Pilotti S, et al. miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma. Oncotarget. 2016;7:12731-47 pubmed publisher
    ..Overall, our study provide both an updated overview of miRNA deregulation in PTC and the first functional evidence that miR-451a exerts tumor suppressor functions in this neoplasia. ..
  26. Mamoori A, Gopalan V, Lu C, Chua T, Morris D, Smith R, et al. Expression pattern of miR-451 and its target MIF (macrophage migration inhibitory factor) in colorectal cancer. J Clin Pathol. 2017;70:308-312 pubmed publisher
    ..The results showed that miR-451 could play a role in development and progression of colorectal cancer and likely by targeting MIF. ..
  27. Riquelme I, Tapia O, Leal P, Sandoval A, Varga M, Letelier P, et al. miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway. Cell Oncol (Dordr). 2016;39:23-33 pubmed publisher
    ..Our expression analyses and in vitro functional assays suggest that miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in primary GCs as well as in GC-derived AGS cells. ..
  28. Li Z, Wu S, Lv S, Wang H, Wang Y, Guo Q. Suppression of liver receptor homolog-1 by microRNA-451 represses the proliferation of osteosarcoma cells. Biochem Biophys Res Commun. 2015;461:450-5 pubmed publisher
    ..Results showed that LRH-1 is implicated in osteosarcoma. Therefore, miR-451-induced suppression of LRH-1 can be a novel therapy to treat osteosarcoma. ..
  29. Grassmann F, Schoenberger P, Brandl C, Schick T, Hasler D, Meister G, et al. A circulating microrna profile is associated with late-stage neovascular age-related macular degeneration. PLoS ONE. 2014;9:e107461 pubmed publisher
    ..In addition, knockdown of hsa-mir-361-5p resulted in increased neovascularization in an in vitro angiogenesis assay. ..
  30. Murata K, Yoshitomi H, Furu M, Ishikawa M, Shibuya H, Ito H, et al. MicroRNA-451 down-regulates neutrophil chemotaxis via p38 MAPK. Arthritis Rheumatol. 2014;66:549-59 pubmed publisher
    ..In SKG mice, miR-451 treatment reduced the severity of arthritis and the number of infiltrating cells. These results suggest that miR-451 suppresses neutrophil chemotaxis via p38 MAPK and is a potential target in the treatment of RA. ..
  31. Wu Z, Li W, Lin S, Wang C, Cai L, Lu J, et al. MicroRNA expression profile of bromocriptine-resistant prolactinomas. Mol Cell Endocrinol. 2014;395:10-8 pubmed publisher
    ..Mir-93 directly affected p21 expression in MMQ cells by targeting the 3'-UTR. Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. ..
  32. Zhang T, Sun Q, Liu T, Chen J, Du S, Ren C, et al. MiR-451 increases radiosensitivity of nasopharyngeal carcinoma cells by targeting ras-related protein 14 (RAB14). Tumour Biol. 2014;35:12593-9 pubmed publisher
    ..Downregulation of RAB14 partially replicated the miR-451-mediated DSBs induced by ionizing radiation (IR). MiR-451 could be a potential target for enhancing radiosensitivity of NPC cells by targeting RAB14. ..
  33. Wang J, Lei Z, Guo Y, Wang T, Qin Z, Xiao H, et al. miRNA-regulated delivery of lincRNA-p21 suppresses β-catenin signaling and tumorigenicity of colorectal cancer stem cells. Oncotarget. 2015;6:37852-70 pubmed publisher
    ..Taken together, these findings suggest that lncRNAs may be promising therapeutic molecules to eradicate CSCs and MREs of tumor-suppressor miRNAs, such as miR-451, may be exploited to ensure the specificity of CSC-targeting strategies. ..
  34. Zhang M, Wu W, Gao M, Fei Z. MicroRNA-451 as a prognostic marker for diagnosis and lymph node metastasis of papillary thyroid carcinoma. Cancer Biomark. 2017;19:437-445 pubmed publisher
    ..We concluded that miR-451 expression is a reliable FFPE tissue biomarker for PTC malignancies and it may have potentials to become a noninvasive, blood-based biomarker for PTC diagnosis and evaluation of LN status. ..
  35. Grant J, Morecroft I, Dempsie Y, van Rooij E, MacLean M, Baker A. Transient but not genetic loss of miR-451 is protective in the development of pulmonary arterial hypertension. Pulm Circ. 2013;3:840-50 pubmed publisher
    ..Genetic deletion of miR-451 had no beneficial effect on indices of PAH, potentially because of pathway redundancy compensating for the loss of miR-451. ..
  36. Chen Q, Hu H, Jiao D, Yan J, Xu W, Tang X, et al. miR-126-3p and miR-451a correlate with clinicopathological features of lung adenocarcinoma: The underlying molecular mechanisms. Oncol Rep. 2016;36:909-17 pubmed publisher
    ..In conclusion, miR-126-3p and miR-451a predicted the severity of lung adenocarcinoma. However, the possible mechanisms explored by bioinformatics need to be further validated. ..
  37. Du J, Liu S, He J, Liu X, Qu Y, Yan W, et al. MicroRNA-451 regulates stemness of side population cells via PI3K/Akt/mTOR signaling pathway in multiple myeloma. Oncotarget. 2015;6:14993-5007 pubmed
    ..Our findings offer insights into the mechanisms regulating MM SP cells and provide a novel strategy to overcome resistance to existing therapies against myeloma. ..
  38. Ansari K, Ogawa D, Rooj A, Lawler S, Krichevsky A, Johnson M, et al. Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor. Cell Rep. 2015;11:902-909 pubmed publisher
    ..These findings uncover miR-451 as a major effector of glucose-regulated AMPK signaling, allowing tumor cell adaptation to variations in nutrient availability in the tumor microenvironment. ..
  39. Morandi F, Pistoia V. Soluble HLA-G modulates miRNA-210 and miRNA-451 expression in activated CD4+ T lymphocytes. Int Immunol. 2013;25:279-85 pubmed publisher
    ..In conclusion, sHLA-G triggered a modulation of miRNA expression that may in turn modulate downstream gene expression, thus affecting CD4(+) T-cell function. ..
  40. Song L, Su M, Wang S, Zou Y, Wang X, Wang Y, et al. MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1. J Cell Mol Med. 2014;18:2266-74 pubmed publisher
    ..The down-regulation of miR-451 may contribute to the development of HCM and may be a potential therapeutic target for this disease. ..
  41. Yuan J, Lang J, Liu C, Zhou K, Chen L, Liu Y. The expression and function of miRNA-451 in osteosarcoma. Med Oncol. 2015;32:324 pubmed publisher
    ..These findings indicate that miR-451 may act not only as a novel diagnostic and prognostic marker, but also as a potential target for molecular therapy of osteosarcoma. ..
  42. Wang Z, Zhang H, Zhang P, Li J, Shan Z, Teng W. Upregulation of miR-2861 and miR-451 expression in papillary thyroid carcinoma with lymph node metastasis. Med Oncol. 2013;30:577 pubmed publisher
    ..007 and 0.001, respectively). Upregulated expression of miR-2861 and miR-451 in PTC with LN metastasis represents a unique miRNA signature associated with the prognosis and progression of PTC...
  43. Zhao K, Wang L, Li T, Zhu M, Zhang C, Chen L, et al. The role of miR-451 in the switching between proliferation and migration in malignant glioma cells: AMPK signaling, mTOR modulation and Rac1 activation required. Int J Oncol. 2017;50:1989-1999 pubmed publisher
    ..Our results highlight the need to consider opposing roles of a therapeutic target which, while suppressing tumor cell proliferation, could also promote cell infiltration. ..
  44. Wang G, Zhu J, Zhang J, Li Q, Li Y, He J, et al. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J. 2010;31:659-66 pubmed publisher
    ..Elevated cardiac-specific miR-208a in plasma may be a novel biomarker for early detection of myocardial injury in humans. ..
  45. Zang W, Yang X, Wang T, Wang Y, Du Y, Chen X, et al. MiR-451 inhibits proliferation of esophageal carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1. World J Gastroenterol. 2015;21:5867-76 pubmed publisher
    ..These findings suggest that miR-451 might be a novel prognostic biomarker and a potential target for the treatment of esophageal squamous cell carcinoma in the future. ..
  46. Liu N, Jiang N, Guo R, Jiang W, He Q, Xu Y, et al. MiR-451 inhibits cell growth and invasion by targeting MIF and is associated with survival in nasopharyngeal carcinoma. Mol Cancer. 2013;12:123 pubmed publisher
    ..MIF was verified as a direct target of miR-451, and MIF regulated NPC cell growth and invasion. The newly identified miR-451/MIF pathway provides insight into NPC initiation and progression, and may represent a novel therapeutic target. ..
  47. Su Z, Ni L, Yu W, Yu Z, Chen D, Zhang E, et al. MicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma. Mol Med Rep. 2015;11:2248-54 pubmed publisher
    ..05). In the present study, it was determined that miR‑451a may have an important role as a tumor enhancer in RCC. These results imply that miR‑451a may be a promising therapeutic target for the treatment of RCC. ..
  48. Zhu H, Wu H, Liu X, Evans B, Medina D, Liu C, et al. Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol. 2008;76:582-8 pubmed publisher
  49. Liu W, Liu S, He Y, Huang R, Deng S, Ni G, et al. MiR-451 suppresses proliferation, migration and promotes apoptosis of the human osteosarcoma by targeting macrophage migration inhibitory factor. Biomed Pharmacother. 2017;87:621-627 pubmed publisher
    ..MiR-451/MIF may be a novel therapeutic target in treatment of osteosarcoma. ..
  50. Beltrami C, Besnier M, Shantikumar S, Shearn A, Rajakaruna C, Laftah A, et al. Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. Mol Ther. 2017;25:679-693 pubmed publisher
    ..Collectively, our data support the concept that PF exosomes orchestrate vascular repair via miRNA transfer. ..
  51. Wecker T, Hoffmeier K, Plötner A, Grüning B, Horres R, Backofen R, et al. MicroRNA Profiling in Aqueous Humor of Individual Human Eyes by Next-Generation Sequencing. Invest Ophthalmol Vis Sci. 2016;57:1706-13 pubmed publisher
    ..The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-? and Wnt, which are important in intraocular pressure regulation and glaucoma. ..
  52. Zhang F, Huang W, Sheng M, Liu T. MiR-451 inhibits cell growth and invasion by targeting CXCL16 and is associated with prognosis of osteosarcoma patients. Tumour Biol. 2015;36:2041-8 pubmed publisher
    ..These observations demonstrated that miR-451 may play an important role in tumor growth and metastasis in osteosarcoma. ..
  53. Li M, Song Q, Song Q, Li H, Lou Y, Wang L. Circulating miR-25-3p and miR-451a May Be Potential Biomarkers for the Diagnosis of Papillary Thyroid Carcinoma. PLoS ONE. 2015;10:e0132403 pubmed publisher
    ..8% and 88.9%, and specificity of 68.8% and 66.7% for distinguishing PTC from benign nodules, respectively. Our findings suggest that the levels of plasma miR-25-3p and miR-451a may be valuable for the diagnosis of PTC. ..
  54. Dore L, Amigo J, Dos Santos C, Zhang Z, Gai X, Tobias J, et al. A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci U S A. 2008;105:3333-8 pubmed publisher
    ..These results reveal a miRNA locus that is required for erythropoiesis and uncover a new regulatory axis through which GATA-1 controls this process. ..
  55. Gu X, Xue J, Han S, Qian S, Zhang W. Circulating microRNA-451 as a predictor of resistance to neoadjuvant chemotherapy in breast cancer. Cancer Biomark. 2016;16:395-403 pubmed publisher
    ..We laid a foundation for further research on the resistance to NACT in BC treatment. ..
  56. Graham A, Falcone T, Nothnick W. The expression of microRNA-451 in human endometriotic lesions is inversely related to that of macrophage migration inhibitory factor (MIF) and regulates MIF expression and modulation of epithelial cell survival. Hum Reprod. 2015;30:642-52 pubmed publisher
    What is the role of microRNA-451 (miR-451) in human endometriotic tissue? miR451 expression was elevated in endometriotic lesion tissue. MiR451 modulated the expression of macrophage migration inhibitory factor and limited cell survival...
  57. Chen D, Huang J, Zhang K, Pan B, Chen J, De W, et al. MicroRNA-451 induces epithelial-mesenchymal transition in docetaxel-resistant lung adenocarcinoma cells by targeting proto-oncogene c-Myc. Eur J Cancer. 2014;50:3050-67 pubmed publisher
  58. Bostjancic E, Zidar N, Glavac D. MicroRNA microarray expression profiling in human myocardial infarction. Dis Markers. 2009;27:255-68 pubmed publisher
    ..Finally, qRT-PCR analysis confirmed dysregulation of 7 miRNAs, miR-150, miR-186, miR-210, miR-451, and muscle-specific, miR-1 and miR-133a/b; all of these are believed to be involved in various physiological and pathological processes. ..
  59. Yang J, Maurin T, Robine N, Rasmussen K, Jeffrey K, Chandwani R, et al. Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proc Natl Acad Sci U S A. 2010;107:15163-8 pubmed publisher
    ..Beyond the demonstration of an alternative strategy to direct gene silencing, these observations open the way for transgenic rescue of Dicer conditional knockouts. ..
  60. Fukumoto I, Kinoshita T, Hanazawa T, Kikkawa N, Chiyomaru T, Enokida H, et al. Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature. Br J Cancer. 2014;111:386-94 pubmed publisher
    ..Our miRNA signature and functional analysis of targets regulated by tumour suppressive miR-451a provide new insights into the potential mechanisms of HSCC oncogenesis and metastasis. ..
  61. Liu Z, Miao T, Feng T, Jiang Z, Li M, Zhou L, et al. miR-451a Inhibited Cell Proliferation and Enhanced Tamoxifen Sensitive in Breast Cancer via Macrophage Migration Inhibitory Factor. Biomed Res Int. 2015;2015:207684 pubmed publisher
    ..In summary, the miR-451a/MIF pathway may play important roles in the biological properties of breast cancer cells and may be a potential therapeutic target for breast cancer. ..
  62. Liu F, Bu Z, Zhao F, Xiao D. Increased T-helper 17 cell differentiation mediated by exosome-mediated microRNA-451 redistribution in gastric cancer infiltrated T cells. Cancer Sci. 2018;109:65-73 pubmed publisher
  63. Soltani I, Douzi K, Gharbi H, Benhassine I, Teber M, Amouri H, et al. Downregulation of miR-451 in Tunisian chronic myeloid leukemia patients: potential implication in imatinib resistance. Hematology. 2017;22:201-207 pubmed publisher
    ..Taken together, our findings suggest that miR-451 and MYC form together a regulatory loop which may act as a potential therapeutic target, and disruption of suggested regulatory loop could help to improve CML therapy. ..
  64. Khazaei S, Nouraee N, Moradi A, Mowla S. A novel signaling role for miR-451 in esophageal tumor microenvironment and its contribution to tumor progression. Clin Transl Oncol. 2017;19:633-640 pubmed publisher
    ..Our findings provide new insights into the stromal role of miR-451 in the esophageal tumor microenvironment as a communicatory molecule and suggest a signaling role for miR-451 in extracellular matrix cross-talks. ..
  65. Zeng Z, Wang K, Li Y, Xia N, Nie S, Lv B, et al. Down-regulation of microRNA-451a facilitates the activation and proliferation of CD4+ T cells by targeting Myc in patients with dilated cardiomyopathy. J Biol Chem. 2017;292:6004-6013 pubmed publisher
  66. Huang J, Zhang K, Chen D, Chen J, Feng B, Song H, et al. MicroRNA-451: epithelial-mesenchymal transition inhibitor and prognostic biomarker of hepatocelluar carcinoma. Oncotarget. 2015;6:18613-30 pubmed
    ..Thus, targeting miR-451/c-Myc/Erk1/2 axis may be a potential strategy for the treatment of metastatic HCC. ..
  67. Meng Y, He X, Huang Y, Wu Q, Zhou Y, Hao D. Long Noncoding RNA CRNDE Promotes Multiple Myeloma Cell Growth by Suppressing miR-451. Oncol Res. 2017;25:1207-1214 pubmed publisher
  68. Xu H, Mei Q, Shi L, Lu J, Zhao J, Fu Q. Tumor-suppressing effects of miR451 in human osteosarcoma. Cell Biochem Biophys. 2014;69:163-8 pubmed publisher
    ..In conclusion, miR-451 played a tumor-suppressing role through modulating the expression of PGE2 and CCND1, suggesting a novel target for the diagnosis and treatment of osteosarcoma. ..
  69. Guo H, Nan Y, Zhen Y, Zhang Y, Guo L, Yu K, et al. miRNA-451 inhibits glioma cell proliferation and invasion by downregulating glucose transporter 1. Tumour Biol. 2016;37:13751-13761 pubmed
    ..Our results suggest a new direction for the treatment of glioma. ..
  70. Lopotová T, Zackova M, Klamova H, Moravcova J. MicroRNA-451 in chronic myeloid leukemia: miR-451-BCR-ABL regulatory loop?. Leuk Res. 2011;35:974-7 pubmed publisher
    ..Following our observation of miR-451 downregulation in CML, we further show its relation to BCR-ABL activity. Our data together with current literature indicate a more complex relationship of miR-451 and BCR-ABL in CML. ..
  71. Brenner B, Hoshen M, Purim O, David M, Ashkenazi K, Marshak G, et al. MicroRNAs as a potential prognostic factor in gastric cancer. World J Gastroenterol. 2011;17:3976-85 pubmed publisher
    ..This study identified three miRs, miR-451, miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer. Of these, miR-451 had the strongest prognostic impact. ..
  72. Li H, Zeng X, Zhang B, Long J, Zhou B, Tan G, et al. miR-451 inhibits cell proliferation in human hepatocellular carcinoma through direct suppression of IKK-?. Carcinogenesis. 2013;34:2443-51 pubmed publisher
    ..Therefore, these results suggest that miR-451 downregulation plays an important role in promoting proliferation of HCC cells and may provide the basis for the development of novel anti-HCC therapies. ..
  73. Li H, Zhang Y, Cai J, Bian H. MicroRNA-451 inhibits growth of human colorectal carcinoma cells via downregulation of Pi3k/Akt pathway. Asian Pac J Cancer Prev. 2013;14:3631-4 pubmed
    ..Our study confirmed that miR-451 has a repressive role in CRC cells by inhibiting cell growth through down-regulating the P13K/AKT pathway. ..