Gene Symbol: MIR433
Description: microRNA 433
Alias: MIRN433, hsa-mir-433, miRNA433
Species: human

Top Publications

  1. Simon D, Laloo B, Barillot M, Barnetche T, Blanchard C, Rooryck C, et al. A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia. Hum Mol Genet. 2010;19:2015-27 pubmed publisher
    ..Our data showed that, in MG63 osteosarcoma cells, hsa-miR-433 (miR433) down-regulated both the expression of endogenous HDAC6 and that of an enhanced green fluorescent protein-reporter ..
  2. Luo H, Zhang H, Zhang Z, Zhang X, Ning B, Guo J, et al. Down-regulated miR-9 and miR-433 in human gastric carcinoma. J Exp Clin Cancer Res. 2009;28:82 pubmed publisher
    ..The targets of miR-433 and miR-9 were tumor-associated proteins GRB2 and RAB34 respectively. This result provided the related information of miRNAs in gastric carcinoma. ..
  3. Lin X, Rice K, Buzzai M, Hexner E, Costa F, Kilpivaara O, et al. miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation. Leukemia. 2013;27:344-52 pubmed publisher
  4. Guo L, Li H, Wang F, Yu J, He J. The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. Int J Mol Sci. 2013;14:14171-84 pubmed publisher
    ..Taken together, our results showed that miR-433 and miR-127 might act as tumor suppressors in GC, and it may provide novel diagnostic and therapeutic options for human GC clinical operation in the near future. ..
  5. Song G, Wang L. A conserved gene structure and expression regulation of miR-433 and miR-127 in mammals. PLoS ONE. 2009;4:e7829 pubmed publisher
    ..Our studies for the first time demonstrate a conserved gene structure and transcriptional regulation of miR-433 and miR-127 in mammals. The data suggest that the miR-433/127 loci may have evolved from a common gene of origin. ..
  6. Tang X, Lin J, Wang G, Lu J. MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression. PLoS ONE. 2017;12:e0179860 pubmed publisher
    ..Conclusively, our findings further emphasized the vital role of miR-433-3p in DKK1/WNT/?-catenin pathway through decreasing DKK1 expression and inducing osteoblasts differentiation. ..
  7. Sun S, Wang X, Xu X, Di H, Du J, Xu B, et al. MiR-433-3p suppresses cell growth and enhances chemosensitivity by targeting CREB in human glioma. Oncotarget. 2017;8:5057-5068 pubmed publisher
    ..Taken together, these results suggest that miR-433-3p may function as a potential marker in diagnostic and therapeutic target for glioma. ..
  8. Espinosa Díez C, Fierro Fernández M, Sánchez Gómez F, Rodríguez Pascual F, Alique M, Ruiz Ortega M, et al. Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-β-Dependent Fibrogenesis. Antioxid Redox Signal. 2015;23:1092-105 pubmed publisher
    ..We describe for the first time an miRNA, miR-433, capable of directly targeting GCL and promoting functional consequences in endothelial physiology and fibrotic processes by decreasing GSH levels. ..
  9. Dole N, Kapinas K, Kessler C, Yee S, Adams D, Pereira R, et al. A single nucleotide polymorphism in osteonectin 3' untranslated region regulates bone volume and is targeted by miR-433. J Bone Miner Res. 2015;30:723-32 pubmed publisher
    ..2014 American Society for Bone and Mineral Research. ..

More Information


  1. Gotanda K, Hirota T, Matsumoto N, Ieiri I. MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells. BMC Cancer. 2013;13:369 pubmed publisher
    ..This is the first report showing that a miRNA regulating TYMS expression has a significant impact on sensitivity to 5-FU treatment. ..
  2. Xue J, Chen L, Li Z, Hu Y, Yan S, Liu L. MicroRNA-433 inhibits cell proliferation in hepatocellular carcinoma by targeting p21 activated kinase (PAK4). Mol Cell Biochem. 2015;399:77-86 pubmed publisher
    ..These findings will shed light on the roles and mechanisms of miRNA-433 in regulating HCC proliferation, and may benefit future development of therapeutics targeting miRNA-433 and PAK4 in HCC. ..
  3. Weiner Gorzel K, Dempsey E, Milewska M, McGoldrick A, Toh V, Walsh A, et al. Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells. Cancer Med. 2015;4:745-58 pubmed publisher
    ..Our data highlight how the aberrant expression of miR-433 can adversely affect intracellular signaling to mediate chemoresistance in OC cells by driving cellular senescence. ..
  4. Jin Y, Zhang F, Ma Z, Ren Z. MicroRNA 433 regulates nonsense-mediated mRNA decay by targeting SMG5 mRNA. BMC Mol Biol. 2016;17:17 pubmed publisher
    ..The miR-433 targets 3'-UTR of SMG5 and represses the expression of SMG5, whereas NMD activity is decreased when SMG5 is decreased. This discovery provides evidence for microRNA/NMD regulatory mechanism. ..
  5. Yang Z, Tsuchiya H, Zhang Y, Hartnett M, Wang L. MicroRNA-433 inhibits liver cancer cell migration by repressing the protein expression and function of cAMP response element-binding protein. J Biol Chem. 2013;288:28893-9 pubmed publisher
    ..The latter is clustered with miR-433. The results reveal a critical role of miR-433 in mediating HCC cell migration via CREB1. ..
  6. Wang K, Li L, Wu J, Qiu Q, Zhou F, Wu H. The different expression profiles of microRNAs in elderly and young human dental pulp and the role of miR-433 in human dental pulp cells. Mech Ageing Dev. 2015;146-148:1-11 pubmed publisher
  7. Li X, Yang L, Shuai T, Piao T, Wang R. MiR-433 inhibits retinoblastoma malignancy by suppressing Notch1 and PAX6 expression. Biomed Pharmacother. 2016;82:247-55 pubmed publisher
  8. Zhang L, Zhang Y, Zhang X, Zhang Y, Jiang Y, Xiao X, et al. MicroRNA-433 Inhibits the Proliferation and Migration of HUVECs and Neurons by Targeting Hypoxia-Inducible Factor 1 Alpha. J Mol Neurosci. 2017;61:135-143 pubmed publisher
    ..Taken together, our findings indicate that miR-433 plays an important role in response to hypoxia, inhibiting HUVEC and neuron proliferation and migration by down-regulating HIF-1?. ..
  9. De Mena L, Cardo L, Coto E, Miar A, Diaz M, Corao A, et al. FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinson's disease in Spanish patients. Neurosci Lett. 2010;479:22-5 pubmed publisher
    ..None of the patients had miR-433 variants. In conclusion, our work did not confirm the association between rs12720208 and PD, or an effect of miR-433 variants on this disease. ..