Gene Symbol: MIR377
Description: microRNA 377
Alias: MIRN377, hsa-mir-377
Species: human
Products:     MIR377

Top Publications

  1. Beckman J, Chen C, Nguyen J, Thayanithy V, Subramanian S, Steer C, et al. Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217. J Biol Chem. 2011;286:3194-202 pubmed publisher
    ..In summary, these data suggests that the combination of miR-377 and miR-217 help regulate HO-1 protein expression in the presence of hemin. ..
  2. Wang Q, Wang Y, Minto A, Wang J, Shi Q, Li X, et al. MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J. 2008;22:4126-35 pubmed publisher
    ..Thus, overexpression of miR-377 in diabetic nephropathy indirectly leads to increased fibronectin protein production; as such, miR-377 can have a critical role in the pathophysiology of this prevalent human disease. ..
  3. Zhang R, Luo H, Wang S, Chen W, Chen Z, Wang H, et al. MicroRNA-377 inhibited proliferation and invasion of human glioblastoma cells by directly targeting specificity protein 1. Neuro Oncol. 2014;16:1510-22 pubmed publisher
    ..These findings reveal that miR-377/Sp1 signaling that may be required for GBM development and may consequently serve as a therapeutic target for the treatment of GBM. ..
  4. Zehavi L, Schayek H, Jacob Hirsch J, Sidi Y, Leibowitz Amit R, Avni D. MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma. Mol Cancer. 2015;14:68 pubmed publisher
  5. Li B, Xu W, Han L, Chan K, Tsao S, Lee N, et al. MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF. Oncogene. 2017;36:3986-4000 pubmed publisher
  6. Xie H, Liu Y, Du R, Wang B, Chen M, Zhang Y, et al. miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1. Cell Death Dis. 2017;8:e2663 pubmed publisher
    ..Our results highlight a novel role for miR-377-DNMT1-p53 axis in HSF senescence. These findings shed new light on the mechanisms of skin aging and identify future opportunities for its therapeutic prevention. ..
  7. Rastogi B, Kumar A, Raut S, Panda N, Rattan V, Joshi N, et al. Downregulation of miR-377 Promotes Oral Squamous Cell Carcinoma Growth and Migration by Targeting HDAC9. Cancer Invest. 2017;35:152-162 pubmed publisher
    ..Our findings show that miR-377 targets HDAC9 pathway in OSCC, suggesting that miR-377-HDAC9 axis may provide a novel therapeutic target for OSCC therapy. ..
  8. Formosa A, Markert E, Lena A, Italiano D, Finazzi Agrò E, Levine A, et al. MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. Oncogene. 2014;33:5173-82 pubmed publisher
    ..Finally, we identified FZD4, a gene important for epithelial-to-mesenchymal transition in (PCa), as a target of miR-377. ..
  9. Chen G, Lu L, Liu C, Shan L, Yuan D. MicroRNA-377 suppresses cell proliferation and invasion by inhibiting TIAM1 expression in hepatocellular carcinoma. PLoS ONE. 2015;10:e0117714 pubmed publisher
    ..These findings reveal that miR-377 functions as a tumor suppressor and inhibits the proliferation and invasion of HCC cells by targeting TIAM1, which may consequently serve as a therapeutic target for HCC patients. ..

More Information


  1. Wang P, Zhuang C, Huang D, Xu K. Downregulation of miR-377 contributes to IRX3 deregulation in hepatocellular carcinoma. Oncol Rep. 2016;36:247-52 pubmed publisher
    ..The present study provides insights into HCC progression and a novel potential therapeutic target of HCC treatment. ..
  2. Tsirimonaki E, Fedonidis C, Pneumaticos S, Tragas A, Michalopoulos I, Mangoura D. PKC? signalling activates ERK1/2, and regulates aggrecan, ADAMTS5, and miR377 gene expression in human nucleus pulposus cells. PLoS ONE. 2013;8:e82045 pubmed publisher
    ..Moreover, this pathway should be considered as a target for understanding the molecular mechanism of IVD degeneration and for therapeutic restoration of degenerated disks. ..
  3. Wang L, Shao J, Zhang X, Xu M, Zhao J. microRNA-377 suppresses the proliferation of human osteosarcoma MG-63 cells by targeting CDK6. Tumour Biol. 2015;36:3911-7 pubmed publisher
    ..Our data suggest that miR-377 can suppress proliferation in MG-63 cells in part by targeting CDK6. ..
  4. Wang R, Ma Y, Yu D, Zhao J, Ma P. miR-377 functions as a tumor suppressor in human clear cell renal cell carcinoma by targeting ETS1. Biomed Pharmacother. 2015;70:64-71 pubmed publisher
  5. Wen X, Wu J, Peng W, Feng J, Tang J. MicroRNA-377 predicts poor clinical outcome of gastric cancer and induces tumorigenesis by targeting multiple tumor-suppressor genes. Oncol Rep. 2015;34:203-10 pubmed publisher
    ..Collectively, miR-377 potentially served as a new molecular predictive biomarker of GC tumorigenesis and prognosis, which may be useful in targeted therapy and the prognosis of GC patients. ..
  6. Sun C, Li S, Zhang F, Xi Y, Wang L, Bi Y, et al. Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway. Oncotarget. 2016;7:51784-51814 pubmed publisher
    ..Taken together, these observations imply that the NEAT1 modulated the expression of E2F3 gene by acting as a ceRNA, which may build up the missing link between the regulatory miRNA network and NSCLC progression. ..
  7. Azizi M, Fard Esfahani P, Mahmoodzadeh H, Fazeli M, Azadmanesh K, Zeinali S, et al. MiR-377 reverses cancerous phenotypes of pancreatic cells via suppressing DNMT1 and demethylating tumor suppressor genes. Epigenomics. 2017;9:1059-1075 pubmed publisher
    ..Our findings showed that miR-377 through targeting DNMT1 could reduce DNA methylation of some tumor suppressor genes and restore their expression in pancreatic cancer cells. ..
  8. Meng F, Zhang L, Shao Y, Ma Q, Lv H. MicroRNA-377 inhibits non-small-cell lung cancer through targeting AEG-1. Int J Clin Exp Pathol. 2015;8:13853-63 pubmed
    ..In conclusion, our results suggested that miR-377 played an important role in the development of NSCLC by regulating AEG-1 and may be a potential therapeutic target for NSCLC. ..
  9. Chang W, Liu M, Xu J, Fu H, Zhou B, Yuan T, et al. MiR-377 inhibits the proliferation of pancreatic cancer by targeting Pim-3. Tumour Biol. 2016;37:14813-14824 pubmed
    ..Hence, miR-377 may be a potential diagnostic marker and therapeutic target. ..
  10. Ge H, Zou D, Wang Y, Jiang H, Wang L. MicroRNA-377 Downregulates Bcl-xL and Increases Apoptosis in Hepatocellular Carcinoma Cells. Oncol Res. 2017;25:29-34 pubmed publisher
    ..In contrast, overexpression of miR-377 suppressed cell proliferation and increased apoptosis. This study provides new insights for the use of miR-377 as a potential molecular target in HCC therapy. ..
  11. Farrokhnia F, Aplin J, Westwood M, Forbes K. MicroRNA regulation of mitogenic signaling networks in the human placenta. J Biol Chem. 2014;289:30404-16 pubmed publisher
    ..These findings identify miR-377 and let-7a in regulation of endogenous cell growth and miR-145 in the placental response to maternal stimulation and will aid the development of therapeutic strategies for problem pregnancies. ..
  12. Wen Z, Huang W, Feng Y, Cai W, Wang Y, Wang X, et al. MicroRNA-377 regulates mesenchymal stem cell-induced angiogenesis in ischemic hearts by targeting VEGF. PLoS ONE. 2014;9:e104666 pubmed publisher
    ..Thus, microRNA-377 may serve as a novel therapeutic target for stem cell-based treatment of ischemic heart disease. ..