Gene Symbol: MIR340
Description: microRNA 340
Alias: MIRN340, hsa-mir-340
Species: human
Products:     MIR340

Top Publications

  1. Sun Y, Zhao X, Zhou Y, Hu Y. miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect. Oncol Rep. 2012;28:1346-52 pubmed publisher
    ..These results demonstrate that miRNAs (miR-124, miR-137 and miR-340) impair colorectal cancer growth by counteracting the Warburg effect due to regulating alternative splicing of the PKM gene. ..
  2. Zhou X, Wei M, Wang W. MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1. Biochem Biophys Res Commun. 2013;437:653-8 pubmed publisher
  3. Wu Z, Wu Q, Wang C, Wang X, Huang J, Zhao J, et al. miR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met. Cancer. 2011;117:2842-52 pubmed publisher
    ..miR-340 may play an important role in breast cancer progression, suggesting that miR-340 should be further evaluated as a novel biomarker for breast cancer metastasis and prognosis, and potentially a therapeutic target. ..
  4. Unterbruner K, Matthes F, Schilling J, Nalavade R, Weber S, Winter J, et al. MicroRNAs miR-19, miR-340, miR-374 and miR-542 regulate MID1 protein expression. PLoS ONE. 2018;13:e0190437 pubmed publisher
    ..These miRNAs not only regulate MID1 expression but also mTOR signaling and translation of disease associated mRNAs and could therefore serve as potential drugs for future therapy development. ..
  5. Shi L, Chen Z, Wu L, Zheng J, Yang J, Chen X, et al. miR-340 reverses cisplatin resistance of hepatocellular carcinoma cell lines by targeting Nrf2-dependent antioxidant pathway. Asian Pac J Cancer Prev. 2014;15:10439-44 pubmed
    ..Collectively, the results first suggested that lower expression of miR-340 is involved in the development of CDDP resistance in hepatocellular carcinoma cell line, at least partly due to regulating Nrf2-dependent antioxidant pathway. ..
  6. Raychaudhuri M, Bronger H, Buchner T, Kiechle M, Weichert W, Avril S. MicroRNAs miR-7 and miR-340 predict response to neoadjuvant chemotherapy in breast cancer. Breast Cancer Res Treat. 2017;162:511-521 pubmed publisher
    ..Our study identifies miRNAs as promising predictive biomarkers, which could aid in optimization of breast cancer management and treatment stratification. ..
  7. Kim E, Choi Y, Hwang S, Han Y, Park M, Bae I. IL-4, a direct target of miR-340/429, is involved in radiation-induced aggressive tumor behavior in human carcinoma cells. Oncotarget. 2016;7:86836-86856 pubmed publisher
  8. Fiore D, Donnarumma E, Roscigno G, Iaboni M, Russo V, Affinito A, et al. miR-340 predicts glioblastoma survival and modulates key cancer hallmarks through down-regulation of NRAS. Oncotarget. 2016;7:19531-47 pubmed publisher
    ..miR-340 may thus represent a novel marker for glioblastoma diagnosis and prognosis, and may be developed into a tool to improve treatment of glioblastoma. ..
  9. Poenitzsch Strong A, Setaluri V, Spiegelman V. MicroRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma. Arch Biochem Biophys. 2014;563:118-24 pubmed publisher
    ..Given the importance of MAPK signaling in melanoma, these results provide further insight into the pathogenesis of melanoma. ..

More Information


  1. Fernandez S, Risolino M, Mandia N, Talotta F, Soini Y, Incoronato M, et al. miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer. Oncogene. 2015;34:3240-50 pubmed publisher
  2. Yu W, Zhang G, Lu B, Li J, Wu Z, Ma H, et al. MiR-340 impedes the progression of laryngeal squamous cell carcinoma by targeting EZH2. Gene. 2016;577:193-201 pubmed publisher
  3. Huang D, Qiu S, Ge R, He L, Li M, Li Y, et al. miR-340 suppresses glioblastoma multiforme. Oncotarget. 2015;6:9257-70 pubmed
    ..Our findings indicate an important role of miR-340 as a glioma killer, and suggest a potential prognosis biomarker and therapeutic target for GBM. ..
  4. Xu P, Li Y, Zhang H, Li M, Zhu H. MicroRNA-340 Mediates Metabolic Shift in Oral Squamous Cell Carcinoma by Targeting Glucose Transporter-1. J Oral Maxillofac Surg. 2016;74:844-50 pubmed publisher
    ..The findings suggest that miR-340 might act as a molecular switch that contributes to the regulation of glycolysis in OSCC by regulating Glut1 expression. ..
  5. Hou X, Qiao H. Effect of miR-340 on gastric cancer cell proliferation and apoptosis. Int J Clin Exp Pathol. 2015;8:13108-13 pubmed
    ..Annexin V/PI staining demonstrated that miR-340 transfection can decrease cell apoptotic rate (4.58%, 1.98%, 2.11%). MiR-340 can promote tumor cell growth and reduce cell apoptosis effectively. ..
  6. Yan S, Jiang H, Fang S, Yin F, Wang Z, Jia Y, et al. MicroRNA-340 Inhibits Esophageal Cancer Cell Growth and Invasion by Targeting Phosphoserine Aminotransferase 1. Cell Physiol Biochem. 2015;37:375-86 pubmed publisher
    ..The expression of miR-340 was negatively correlated with that of PSAT1 in human ESCC samples. MiR-340 functions as a tumor suppressor by modulating the expression of PSAT1 and may contribute to the progression and invasiveness of ESCC. ..
  7. Li X, Gong X, Chen J, Zhang J, Sun J, Guo M. miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2. Biochem Biophys Res Commun. 2015;460:670-7 pubmed publisher
    ..Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. ..
  8. Wei P, Qiao B, Li Q, Han X, Zhang H, Huo Q, et al. microRNA-340 Suppresses Tumorigenic Potential of Prostate Cancer Cells by Targeting High-Mobility Group Nucleosome-Binding Domain 5. DNA Cell Biol. 2016;35:33-43 pubmed publisher
    ..Thus, miR340 and its target gene HMGN5 can serve as potentially useful therapeutic candidates for prostate cancer treatment.
  9. Sondermeijer B, Bakker A, Halliani A, de Ronde M, Marquart A, Tijsen A, et al. Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340* and miRNA624*. PLoS ONE. 2011;6:e25946 pubmed publisher
    ..Six platelet microRNAs were significantly upregulated (miR340*, miR451, miR454*, miR545:9.1...
  10. Yuan J, Ji H, Xiao F, Lin Z, Zhao X, Wang Z, et al. MicroRNA-340 inhibits the proliferation and invasion of hepatocellular carcinoma cells by targeting JAK1. Biochem Biophys Res Commun. 2017;483:578-584 pubmed publisher
    ..The present findings indicated that miR-340 suppressed HCC cell proliferation and invasion by regulating the JAK1/STAT3 pathway, suggesting its potential as a novel therapeutic target for HCC. ..
  11. Yin G, Zhou H, Xue Y, Yao B, Zhao W. MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2. Oncol Rep. 2016;36:1111-8 pubmed publisher
    ..In conclusion, our data suggest that miR-340 may potentially serve as a novel prognostic biomarker and therapeutic target for gastric cancer. ..
  12. Mohammadi Yeganeh S, Paryan M, Arefian E, Vasei M, Ghanbarian H, Mahdian R, et al. MicroRNA-340 inhibits the migration, invasion, and metastasis of breast cancer cells by targeting Wnt pathway. Tumour Biol. 2016;37:8993-9000 pubmed publisher
    ..By bioinformatic analysis, we confirmed the important role of miR-340 as a pivotal regulator of breast cancer metastasis in targeting previously validated (ROCK1) and potentially novel genes, i.e., (CTNNB1 and c-MYC). ..
  13. Goswami S, Tarapore R, Poenitzsch Strong A, Teslaa J, Grinblat Y, Setaluri V, et al. MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP). J Biol Chem. 2015;290:384-95 pubmed publisher
    ..This regulatory interplay between RNA-binding protein and miRNA highlights an important mechanism for the regulation of MITF in melanocytes and malignant melanomas. ..
  14. Huang K, Tang Y, He L, Dai Y. MicroRNA-340 inhibits prostate cancer cell proliferation and metastasis by targeting the MDM2-p53 pathway. Oncol Rep. 2016;35:887-95 pubmed publisher
    ..Our findings suggest that miR-340 may function as a novel tumor suppressor in PCa through the MDM2-p53 pathway by directly targeting MDM2, which may be a promising miRNA-targeted therapy for PCa. ..
  15. Yamashita D, Kondo T, Ohue S, Takahashi H, Ishikawa M, Matoba R, et al. miR340 suppresses the stem-like cell function of glioma-initiating cells by targeting tissue plasminogen activator. Cancer Res. 2015;75:1123-33 pubmed publisher
    ..Furthermore, we defined tissue plasminogen activator (PLAT) as a critical direct target of miR340 for inhibition...
  16. Wozniak M, Sztiller Sikorska M, Czyz M. Diminution of miR-340-5p levels is responsible for increased expression of ABCB5 in melanoma cells under oxygen-deprived conditions. Exp Mol Pathol. 2015;99:707-16 pubmed publisher
    ..This is the first study showing the relationship between miR-340-5p and expression of ABCB5, a transmembrane transporter involved in drug resistance considered as a marker of melanoma stem-like cells. ..
  17. Jian Q, An Q, Zhu D, Hui K, Liu Y, Chi S, et al. MicroRNA 340 is involved in UVB-induced dendrite formation through the regulation of RhoA expression in melanocytes. Mol Cell Biol. 2014;34:3407-20 pubmed publisher
    ..The significant downregulation of RhoA protein and mRNA expression after UVB irradiation and the modulation of miR-340 expression suggest a key role for miR-340 in regulating UVB-induced dendrite formation and melanosome transport. ..
  18. Hou L, Yu Y, Xie Y, Wang J, Mao J, Zhang B, et al. miR-340 and ZEB1 negative feedback loop regulates TGF-β- mediated breast cancer progression. Oncotarget. 2016;7:26016-26 pubmed publisher
    ..The negative feedback loop regulated TGF-β-mediated breast cancer progression. In conclusion, our data suggested that miR-340 acted as a tumor suppressor in breast cancer progression. ..
  19. Xie W, Qin W, Kang Y, Zhou Z, Qin A. MicroRNA-340 Inhibits Tumor Cell Proliferation and Induces Apoptosis in Endometrial Carcinoma Cell Line RL 95-2. Med Sci Monit. 2016;22:1540-6 pubmed
    ..However, no significant differences were found in p21 expression. CONCLUSIONS MiRNA-340 acts as an anti-oncogene in EC cell line RL 95-2 by inhibition of tumor cell proliferation and induction of apoptosis. ..
  20. Takeyama H, Yamamoto H, Yamashita S, Wu X, Takahashi H, Nishimura J, et al. Decreased miR-340 expression in bone marrow is associated with liver metastasis of colorectal cancer. Mol Cancer Ther. 2014;13:976-85 pubmed publisher
    ..Our data suggest that miR-340 in bone marrow may play an important role in regulating the metastasis cascade of colorectal cancer. ..
  21. Yu J, Wang R, Chen J, Wu J, Dang Z, Zhang Q, et al. miR-340 Inhibits Proliferation and Induces Apoptosis in Gastric Cancer Cell Line SGC-7901, Possibly via the AKT Pathway. Med Sci Monit. 2017;23:71-77 pubmed
    ..The roles of miR-340 in gastric cancer cells may be associated with its regulation of the AKT pathway. Thus, miR-340 may be a potential therapeutic strategy for gastric cancer treatment. ..
  22. Cai H, Lin L, Cai H, Tang M, Wang Z. Combined microRNA-340 and ROCK1 mRNA profiling predicts tumor progression and prognosis in pediatric osteosarcoma. Int J Mol Sci. 2014;15:560-73 pubmed publisher
    ..008). Our data offer convincing evidence, for the first time, that the combined miR-340 downregulation and ROCK1 upregulation may be linked to tumor progression and adverse prognosis in pediatric osteosarcoma. ..
  23. Li P, Sun Y, Liu Q. MicroRNA-340 Induces Apoptosis and Inhibits Metastasis of Ovarian Cancer Cells by Inactivation of NF-x03BA;B1. Cell Physiol Biochem. 2016;38:1915-27 pubmed publisher
    ..miR-340 induced cell apoptosis and inhibited metastasis in OC cells by down-regulation of NF-x03BA;B1. ..
  24. Chen C, Sun Z, Lu X, Wu W, Guo W, Lu J, et al. MiR-340 suppresses cell migration and invasion by targeting MYO10 in breast cancer. Oncol Rep. 2016;35:709-16 pubmed publisher
    ..In brief, miR‑340 plays an important role in breast cancer progression. Thus, miR‑340 may be further explored as a novel biomarker for breast cancer metastasis and prognosis, and potentially a therapeutic target. ..