Gene Symbol: MIR199A1
Description: microRNA 199a-1
Alias: MIR-199-s, MIRN199A1
Species: human

Top Publications

  1. Alexander M, Kawahara G, Motohashi N, Casar J, Eisenberg I, Myers J, et al. MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation. Cell Death Differ. 2013;20:1194-208 pubmed publisher
    ..Together, these studies identify miR-199a-5p as a potential regulator of myogenesis through suppression of WNT-signaling factors that act to balance myogenic cell proliferation and differentiation...
  2. Monastyrskaya K, Sanchez Freire V, Hashemi Gheinani A, Klumpp D, Babiychuk E, Draeger A, et al. miR-199a-5p regulates urothelial permeability and may play a role in bladder pain syndrome. Am J Pathol. 2013;182:431-48 pubmed publisher
    ..Up-regulation of miR-199a-5p and concomitant down-regulation of its multiple targets might be detrimental to the establishment of a tight urothelial barrier, leading to chronic pain. ..
  3. Huang J, Dong B, Zhang J, Kong W, Chen Y, Xue W, et al. miR-199a-3p inhibits hepatocyte growth factor/c-Met signaling in renal cancer carcinoma. Tumour Biol. 2014;35:5833-43 pubmed publisher
    ..Our findings indicated that miR-199a-3p target HGF/c-Met signaling pathway which is crucial for RCC development and suggest that miR-199a-3p may serve as a potential target miRNA for RCC therapy. ..
  4. Duan Z, Choy E, Harmon D, Liu X, Susa M, Mankin H, et al. MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. Mol Cancer Ther. 2011;10:1337-45 pubmed publisher
    ..Restoring miR-199a-3p's function may provide therapeutic benefits in osteosarcoma. ..
  5. Akhtar N, Haqqi T. MicroRNA-199a* regulates the expression of cyclooxygenase-2 in human chondrocytes. Ann Rheum Dis. 2012;71:1073-80 pubmed publisher
    ..IL-1?-induced activation of p38-MAPK correlates inversely with miR199a* expression levels. miR-199a* may be an important regulator of human cartilage homeostasis and a new target for OA therapy. ..
  6. Sakurai K, Furukawa C, Haraguchi T, Inada K, Shiogama K, Tagawa T, et al. MicroRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers. Cancer Res. 2011;71:1680-9 pubmed publisher
    ..This mechanism may offer a partial explanation for why miR-199a-5p and -3p have been reported to be either upregulated or downregulated in a variety of tumors. ..
  7. Ding G, Huang G, Liu H, Liang H, Ni Y, Ding Z, et al. MiR-199a suppresses the hypoxia-induced proliferation of non-small cell lung cancer cells through targeting HIF1?. Mol Cell Biochem. 2013;384:173-80 pubmed
  8. Chen R, Alvero A, Silasi D, Kelly M, Fest S, Visintin I, et al. Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. Oncogene. 2008;27:4712-23 pubmed publisher
    ..Identification of these markers in patients' tumor samples may facilitate the adequate selection of treatment and open new venues for the development of effective therapy for chemoresistant ovarian cancers. ..
  9. Lee C, Kim Y, Kim E, Meng Z, Huang W, Hwang S, et al. Farnesoid X receptor protects hepatocytes from injury by repressing miR-199a-3p, which increases levels of LKB1. Gastroenterology. 2012;142:1206-1217.e7 pubmed publisher
    ..FXR therefore protects hepatocytes from injury by repressing miR-199a-3p and thereby increasing levels of LKB1. ..

More Information


  1. Cheung H, Davis A, Lee T, Pang A, Nagrani S, Rennert O, et al. Methylation of an intronic region regulates miR-199a in testicular tumor malignancy. Oncogene. 2011;30:3404-15 pubmed publisher
    ..This report identifies DNA methylation, miR-199a dysregulation and PODXL as critical factors in tumor malignancy. ..
  2. Gu S, Cheung H, Lee T, Lu G, Poon W, Chan W. Molecular mechanisms of regulation and action of microRNA-199a in testicular germ cell tumor and glioblastomas. PLoS ONE. 2013;8:e83980 pubmed publisher
    ..By studying the mechanisms that control the expressions of miR-199a and its various downstream targets, we hope to use miR-199a as a model to understand the complexity of miRNA biology. ..
  3. Su S, Chang Y, Andreu Vieyra C, Fang J, Yang Z, Han B, et al. miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. Oncogene. 2013;32:4694-701 pubmed publisher
    ..Together, our results indicate that the delivery of co-transcribed miRNAs can efficiently suppress GRP78 levels and GRP78-mediated chemoresistance, and suggest that this strategy holds therapeutic potential. ..
  4. Tsukigi M, Bilim V, Yuuki K, Ugolkov A, Naito S, Nagaoka A, et al. Re-expression of miR-199a suppresses renal cancer cell proliferation and survival by targeting GSK-3?. Cancer Lett. 2012;315:189-97 pubmed publisher
    ..Our results demonstrate low miR-199a expression as a feature of advanced RCCs, identify miR-199a as a negative regulator of GSK-3?, and suggest re-expression of pre-miR-199a as a new potential treatment of RCC. ..
  5. He J, Jing Y, Li W, Qian X, Xu Q, Li F, et al. Roles and mechanism of miR-199a and miR-125b in tumor angiogenesis. PLoS ONE. 2013;8:e56647 pubmed publisher
    ..This study provides a rationale for new therapeutic approach to suppress tumor angiogenesis using miR-199a, miR-125b, or their mimics for ovarian cancer treatment in the future. ..
  6. Kim S, Lee U, Kim M, Lee E, Kim J, Lee M, et al. MicroRNA miR-199a* regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2). J Biol Chem. 2008;283:18158-66 pubmed publisher
    ..Coordinated down-regulation of both MET and its downstream effector ERK2 by miR-199a* may be effective in inhibiting not only cell proliferation but also motility and invasive capabilities of tumor cells. ..
  7. Chan Y, Roy S, Huang Y, Khanna S, Sen C. The microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway. J Biol Chem. 2012;287:41032-43 pubmed publisher
    ..Thus, down-regulation of miR-199a-5p is involved in the induction of wound angiogenesis through derepressing of the Ets-1-MMP1 pathway. ..
  8. Henry J, Park J, Jiang J, Kim J, Nagorney D, Roberts L, et al. miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. 2010;403:120-5 pubmed publisher
    ..An inverse correlation between the expression of miR-199a-3p and CD44 protein was noted in primary HCC specimens. The ability of miR-199a-3p to selectively kill CD44+ HCC may be a useful targeted therapy for CD44+ HCC. ..
  9. Gu S, Chan W. Flexible and versatile as a chameleon-sophisticated functions of microRNA-199a. Int J Mol Sci. 2012;13:8449-66 pubmed publisher
    ..This review provides a comprehensive survey of the literature on miR-199a as an example of the complexity of miRNA biology and suggests future directions for miRNA research. ..
  10. Qu Y, Huang X, Li Z, Liu J, Wu J, Chen D, et al. miR-199a-3p inhibits aurora kinase A and attenuates prostate cancer growth: new avenue for prostate cancer treatment. Am J Pathol. 2014;184:1541-9 pubmed publisher
    ..Revealing novel mechanisms for oncogene inhibition by miRNA-mediated pathways offers new avenues for PCa treatment. ..
  11. Chen B, Gu S, Suen Y, Li L, Chan W. microRNA-199a-3p, DNMT3A, and aberrant DNA methylation in testicular cancer. Epigenetics. 2014;9:119-28 pubmed publisher
  12. Raimondi L, Amodio N, Di Martino M, Altomare E, Leotta M, Caracciolo D, et al. Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity. Oncotarget. 2014;5:3039-54 pubmed
  13. Fan X, Zhou S, Zheng M, Deng X, Yi Y, Huang T. MiR-199a-3p enhances breast cancer cell sensitivity to cisplatin by downregulating TFAM (TFAM). Biomed Pharmacother. 2017;88:507-514 pubmed publisher
    ..These results show that miR-199a-3p is able to attenuate cisplatin resistance in breast cancer cells through inhibiting TFAM expression. ..
  14. Wan D, He S, Xie B, Xu G, Gu W, Shen C, et al. Aberrant expression of miR-199a-3p and its clinical significance in colorectal cancers. Med Oncol. 2013;30:378 pubmed publisher
    ..These results suggested that miR-199a-3p may serve as an efficient biomarker for diagnosis and novel prognostic indicator in colorectal cancer. ..
  15. Zhang L, Lou J, Lu M, Gao C, Zhao S, Li B, et al. Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma. EMBO J. 2015;34:2671-85 pubmed publisher
  16. Celià Terrassa T, Liu D, Choudhury A, Hang X, Wei Y, Zamalloa J, et al. Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis. Nat Cell Biol. 2017;19:711-723 pubmed publisher
    ..Our study therefore reveals a common mechanism shared by normal and malignant stem cells to protect them from suppressive immune cytokine signalling. ..
  17. Wang Q, Yu X, Li Q, Qin L, Tan S, Zeng X, et al. Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma. Oncotarget. 2016;7:79365-79371 pubmed publisher
    ..018). Our results suggest that MET rs1621 polymorphism, alone and combined with miR-199a rs74723057, may influence susceptibility to HCC. Further large-scale association studies and functional studies are needed to validate our findings. ..
  18. Yin J, Hou P, Wu Z, Wang T, Nie Y. Circulating miR-375 and miR-199a-3p as potential biomarkers for the diagnosis of hepatocellular carcinoma. Tumour Biol. 2015;36:4501-7 pubmed publisher
    ..Our data suggested that circulating miR-375 and miR-199a-3p could be a novel serum biomarker for HCC. Nevertheless, further validating and improving study with larger sample should be conducted to confirm our results. ..
  19. Chen M, Lin H, Shen C, Ma Y, Wang F, Zhao H, et al. PU.1-Regulated Long Noncoding RNA lnc-MC Controls Human Monocyte/Macrophage Differentiation through Interaction with MicroRNA 199a-5p. Mol Cell Biol. 2015;35:3212-24 pubmed publisher
    ..1, by soaking up miR-199a-5p and releasing ACVR1B expression. Thus, we reveal a novel regulatory mechanism, comprising PU.1, lnc-MC, miR-199a-5p, and ACVR1B, in monocyte/macrophage differentiation. ..
  20. Kuninty P, Bojmar L, Tjomsland V, Larsson M, Storm G, Östman A, et al. MicroRNA-199a and -214 as potential therapeutic targets in pancreatic stellate cells in pancreatic tumor. Oncotarget. 2016;7:16396-408 pubmed publisher
    ..Taken together, this study reveals miR-199a-3p and miR-214-3p as major regulators of PSC activation and PSC-induced pro-tumoral effects, representing them as key therapeutic targets in pancreatic cancer. ..
  21. Kim B, Yoo H, Kim I, Park J, Kim Yoon S. FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer. BMB Rep. 2015;48:360-6 pubmed
    ..These results suggest that overexpression of FZD6, mediated by reduced expression of miR-199a-5p, may play an important role in the development of CRC. ..
  22. Chao C, Wu P, Huang H, Chung H, Chou Y, Cai B, et al. Downregulation of miR-199a/b-5p is associated with GCNT2 induction upon epithelial-mesenchymal transition in colon cancer. FEBS Lett. 2017;591:1902-1917 pubmed publisher
    ..Overexpression of miR-199a/b-5p decreases GCNT2 expression and suppresses I antigen production. Based on these findings, we propose that miR-199a/b-5p regulates GCNT2 and I antigen expression in colon cancer cells undergoing EMT. ..
  23. Suzuki T, Mizutani K, Minami A, Nobutani K, Kurita S, Nagino M, et al. Suppression of the TGF-?1-induced protein expression of SNAI1 and N-cadherin by miR-199a. Genes Cells. 2014;19:667-75 pubmed publisher
    ..These results indicate that miR-199a suppresses the TGF-?1-induced protein expression of SNAI1 and N-cadherin. ..
  24. Huang G, Shan H, Li D, Zhou B, Pang P. MiR-199a-5p suppresses tumorigenesis by targeting clathrin heavy chain in hepatocellular carcinoma. Cell Biochem Funct. 2017;35:98-104 pubmed publisher
    ..We conclude that the frequently down-regulated miR-199a-5p can regulate CLTC and might function as a tumor suppressor in HCC. Therefore, miR-199a-5p may serve as a useful therapeutic agent for miRNA-based HCC therapy. ..
  25. Zhou G, Lu M, Chen J, Li C, Zhang J, Chen J, et al. Identification of miR-199a-5p in serum as noninvasive biomarkers for detecting and monitoring osteosarcoma. Tumour Biol. 2015;36:8845-52 pubmed publisher
    ..8606. Serum levels of miR-199a-5p were significantly lower in post- than preoperative samples. The results indicated the potential of circulating miRNAs as novel noninvasive biomarkers for detecting and monitoring osteosarcoma. ..
  26. Nonaka R, Nishimura J, Kagawa Y, Osawa H, Hasegawa J, Murata K, et al. Circulating miR-199a-3p as a novel serum biomarker for colorectal cancer. Oncol Rep. 2014;32:2354-8 pubmed publisher
    ..Furthermore, clinical and pathological survey indicated that high expression of miR-199a-3p was significantly associated with deep wall invasion. Our data suggest that circulating miR-199a-3p could be a novel serum biomarker for CRC. ..
  27. Yamac A, Kucukbuzcu S, Ozansoy M, Gok O, Oz K, Erturk M, et al. Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery. Cardiovasc Pathol. 2016;25:232-6 pubmed publisher
    ..001). Altered expression of the SIRT1 protein regulating miR-199a in human atrial tissue was found to be related to the occurrence of POAF, indicating its usefulness as a biomarker for cardiac surgery management. ..
  28. Wu Z, Lu L, Liang J, Guo X, Zhang P, Luo S. Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts. Genet Mol Res. 2014;13:2727-38 pubmed publisher
    ..The significantly lower expression of miRNA-199a-5p in keloids likely influences the cell cycle of KFs and restrains their proliferation, suggesting that miR-199a-5p probably plays a role in the regulation of KF proliferation. ..
  29. Zhang J, Wu G, Zhang Y, Feng Z, Zhu S. Propofol induces apoptosis of hepatocellular carcinoma cells by upregulation of microRNA-199a expression. Cell Biol Int. 2013;37:227-32 pubmed publisher
    ..Propofol can effectively induce apoptosis of HCC cells and modulation of miR-199a possibly contributes to the anti-tumour action of Propofol. Hence, Propofol might be an effective drug for HCC. ..
  30. Li Y, Wu Q, Liu J, Fan Y, Yu K, Cai Y. miR‑199a‑3p is involved in the pathogenesis and progression of diabetic neuropathy through downregulation of SerpinE2. Mol Med Rep. 2017;16:2417-2424 pubmed publisher
    ..The present findings suggested that miR‑199a‑3p may have potential as a novel therapeutic target for the treatment of patients with DN. ..
  31. Si T, Liu C, Xu K, Gui Y. [Association of miR-199a expression with clinicopathologic characteristics and prognosis of renal cell carcinoma]. Nan Fang Yi Ke Da Xue Xue Bao. 2012;32:1568-71 pubmed
    ..miR-199a can serve as a promising prognostic factor of renal cell carcinoma. ..
  32. Zuberi M, Khan I, Gandhi G, Ray P, Saxena A. The conglomeration of diagnostic, prognostic and therapeutic potential of serum miR-199a and its association with clinicopathological features in epithelial ovarian cancer. Tumour Biol. 2016;37:11259-66 pubmed publisher
  33. Mungunsukh O, Day R. Transforming growth factor-?1 selectively inhibits hepatocyte growth factor expression via a micro-RNA-199-dependent posttranscriptional mechanism. Mol Biol Cell. 2013;24:2088-97 pubmed publisher
    ..Taken together, these findings demonstrate that HGF is distinctly regulated at the posttranscriptional level from its antagonist NK2. ..
  34. Kinose Y, Sawada K, Nakamura K, Sawada I, Toda A, Nakatsuka E, et al. The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma. Oncotarget. 2015;6:11342-56 pubmed
    ..Therefore, miR-199a-3p is a potential target for treating ovarian cancer dissemination. ..
  35. Lunavat T, Cheng L, Kim D, Bhadury J, Jang S, Lässer C, et al. Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells--Evidence of unique microRNA cargos. RNA Biol. 2015;12:810-23 pubmed publisher
  36. Chen B, Suen Y, Gu S, Li L, Chan W. A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor. Sci Rep. 2014;4:6413 pubmed publisher
    ..Collectively, our findings highlighted a miR-199a/miR-214/PSMD10/TP53/DNMT1 self-regulatory network, which might be a potential therapeutic target in the treatment of TGCT. ..
  37. Li Z, Song Y, Liu L, Hou N, An X, Zhan D, et al. miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation. Cell Death Differ. 2017;24:1205-1213 pubmed publisher
    ..These results reveal a novel role of miR-199a as a key regulator of cardiac autophagy, suggesting that targeting miRNAs controlling autophagy as a potential therapeutic strategy for cardiac disease. ..
  38. Wang H, Gao H, Duan S, Song X. Inhibition of microRNA-199a-5p reduces the replication of HCV via regulating the pro-survival pathway. Virus Res. 2015;208:7-12 pubmed publisher
    ..miR-199a-5p might be a potential drug target for developing a novel strategy to combat HCV infection. ..
  39. Chatila W, Criner G, Hancock W, Akimova T, Moldover B, Chang J, et al. Blunted expression of miR-199a-5p in regulatory T cells of patients with chronic obstructive pulmonary disease compared to unaffected smokers. Clin Exp Immunol. 2014;177:341-52 pubmed publisher
    ..These findings suggest that the abnormal repression of miR-199a-5p in patients with COPD compared to unaffected smokers may be involved in modulating the adaptive immune balance in favour of a Th1 and Th17 response. ..
  40. Zhao X, He L, Li T, Lu Y, Miao Y, Liang S, et al. SRF expedites metastasis and modulates the epithelial to mesenchymal transition by regulating miR-199a-5p expression in human gastric cancer. Cell Death Differ. 2014;21:1900-13 pubmed publisher
    ..As increased activity of the SRF/miR-199a-5p/E-cadherin pathway appears to promote GC cell EMT and metastasis, these regulators may therefore be developed as therapeutic targets or biomarkers for GC progression. ..
  41. Li J, Zhang Z, Xiong L, Guo C, Jiang T, Zeng L, et al. SNHG1 lncRNA negatively regulates miR-199a-3p to enhance CDK7 expression and promote cell proliferation in prostate cancer. Biochem Biophys Res Commun. 2017;487:146-152 pubmed publisher
    ..Taken together, these findings elucidated a novel mechanism of prostate cancer progression. Thus, SNHG1 might serve as a potential target for prostate cancer therapies. ..
  42. Yi H, Liang B, Jia J, Liang N, Xu H, Ju G, et al. Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells. FEBS Lett. 2013;587:436-43 pubmed publisher
    ..Furthermore, we show that miR-199a-5p sensitizes MDA-MB-231 cells to irradiation. Therefore, our data identify miR-199a-5p as a novel and unique regulator of autophagy, which plays an important role in cancer biology and cancer therapy. ..
  43. Hassan T, Carroll T, Buckley P, Cummins R, O Neill S, McElvaney N, et al. miR-199a-5p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and ?1-antitrypsin deficiency. Am J Respir Crit Care Med. 2014;189:263-73 pubmed publisher
    ..miR-199a-5p is a key regulator of the unfolded protein response in AAT-deficient monocytes, and epigenetic silencing of its expression regulates this process in chronic obstructive pulmonary disease. ..
  44. Ukai T, Sato M, Akutsu H, Umezawa A, Mochida J. MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism. J Orthop Res. 2012;30:1915-22 pubmed publisher
    ..We believe that miR-199a-3p and miR-193b are involved in the senescence of chondrocytes, and miR-320c is involved in the juvenile properties of chondrocytes...
  45. Liu R, Liu C, Zhang D, Liu B, Chen X, Rycaj K, et al. miR-199a-3p targets stemness-related and mitogenic signaling pathways to suppress the expansion and tumorigenic capabilities of prostate cancer stem cells. Oncotarget. 2016;7:56628-56642 pubmed publisher
  46. Morita K, Shirabe K, Taketomi A, Soejima Y, Yoshizumi T, Uchiyama H, et al. Relevance of microRNA-18a and microRNA-199a-5p to hepatocellular carcinoma recurrence after living donor liver transplantation. Liver Transpl. 2016;22:665-76 pubmed publisher
    ..MiR-18a and miR-199a-5p could be novel therapeutic targets of recurrent HCC after LDLT. Liver Transplantation 22 665-676 2016 AASLD. ..
  47. Kim J, Badawi M, Park J, Jiang J, Mo X, Roberts L, et al. Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151. Int J Oncol. 2016;49:2037-2045 pubmed publisher
    ..We report that CD151 is a target of miR-199a-3p and that increased CD151 protein resulting from reduced miR-199a-3p could contribute to the development of metastatic HCC. ..
  48. Triozzi P, Achberger S, Aldrich W, Crabb J, Saunthararajah Y, Singh A. Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma. Clin Epigenetics. 2016;8:80 pubmed publisher
    ..They also suggest that potentially useful blood miRs may be derived from the host response as well as the tumor. ..
  49. Gui R, Huang R, Zhang J, Wen X, Nie X. MicroRNA-199a-5p inhibits VEGF-induced tumorigenesis through targeting oxidored-nitro domain-containing protein 1 in human HepG2 cells. Oncol Rep. 2016;35:2216-22 pubmed publisher
    ..These results indicate that miR-199a-5p is critical for regulating cell proliferation and migration by targeting and upregulating NOR1 in human HepG2 cells. ..
  50. Song J, Gao L, Yang G, Tang S, Xie H, Wang Y, et al. MiR-199a regulates cell proliferation and survival by targeting FZD7. PLoS ONE. 2014;9:e110074 pubmed publisher
  51. Liu G, Huang Y, Tzeng H, Tsai C, Wang S, Tang C. CCL5 promotes vascular endothelial growth factor expression and induces angiogenesis by down-regulating miR-199a in human chondrosarcoma cells. Cancer Lett. 2015;357:476-87 pubmed publisher
    ..Taken together, these results demonstrated that CCL5 promotes VEGF-dependent angiogenesis in human chondrosarcoma cells by downregulating miR-199a. ..
  52. Liu J, Wang Y, Cui J, Sun M, Pu Z, Wang C, et al. miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit+ cells to promote proliferation and inhibit apoptosis through a negative feedback loop. Stem Cell Res Ther. 2017;8:127 pubmed publisher
    ..Therefore, miR199a-3p and P53 are coupled through CABLES1 and comprise a novel negative feedback loop that likely contributes to cardiac c-kit+ cell proliferation and apoptosis. ..
  53. Dai L, Lou W, Zhu J, Zhou X, Di W. MiR-199a inhibits the angiogenic potential of endometrial stromal cells under hypoxia by targeting HIF-1α/VEGF pathway. Int J Clin Exp Pathol. 2015;8:4735-44 pubmed
    ..Therefore, miR-199a may play pivotal roles in the pathogenesis of endometriosis and may become a potential therapeutic target of this disease. ..
  54. Shin V, Siu J, Cheuk I, Ng E, Kwong A. Circulating cell-free miRNAs as biomarker for triple-negative breast cancer. Br J Cancer. 2015;112:1751-9 pubmed publisher
    ..The expression levels were associated with TNM stage and tumour subtypes. Our data suggest that miR-199a-5p could be a TNBC-specific marker with diagnostic value and provide insights into targeted therapy in the treatment of TNBC. ..
  55. Kong Y, Bai P, Sun H, Nan K, Chen N, Qi X. The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer. Int J Biochem Cell Biol. 2012;44:2321-32 pubmed publisher
    ..These findings suggest that miR-199a-5p is a useful therapeutic target for colorectal cancer. ..
  56. Conde Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, et al. A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity. Nat Commun. 2015;6:8093 pubmed publisher
    ..These data reveal a mechanism by which loss of PTEN increases CAV1-mediated dissociation of β-catenin from membranous E-cadherin, which may promote senescence bypass and metastasis. ..
  57. Wang Y, Luo J, Wang X, Yang B, Cui L. MicroRNA-199a-5p Induced Autophagy and Inhibits the Pathogenesis of Ankylosing Spondylitis by Modulating the mTOR Signaling via Directly Targeting Ras Homolog Enriched in Brain (Rheb). Cell Physiol Biochem. 2017;42:2481-2491 pubmed publisher
    ..AS patients with advanced spinal damage had decreased autophagy levels and that miRNA-199a-5p may induce autophagy and inhibit the pathogenesis of AS by modulating the mTOR signaling via direct targeting Rheb. ..
  58. Chen B, Zhang D, Kuai J, Cheng M, Fang X, Li G. Upregulation of miR-199a/b contributes to cisplatin resistance via Wnt/?-catenin-ABCG2 signaling pathway in ALDHA1+ colorectal cancer stem cells. Tumour Biol. 2017;39:1010428317715155 pubmed publisher
  59. Yang G, Yang L, Wang W, Wang J, Wang J, Xu Z. Discovery and validation of extracellular/circulating microRNAs during idiopathic pulmonary fibrosis disease progression. Gene. 2015;562:138-44 pubmed publisher
    ..These studies demonstrated that extracellular/circulating miRNAs in serum could be potentially served as novel regulators influencing disease progression of IPF. ..
  60. Chiang D, Zhang M, Voigt N, Alsina K, Jakob H, Martin J, et al. Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation. Int J Cardiol. 2015;184:190-7 pubmed publisher
    ..Future studies are required to investigate the potential involvement of the gonadotropin releasing hormone receptor and p53 pathways in AF pathogenesis. ..
  61. El Abd N, Fawzy N, El Sheikh S, Soliman M. Circulating miRNA-122, miRNA-199a, and miRNA-16 as Biomarkers for Early Detection of Hepatocellular Carcinoma in Egyptian Patients with Chronic Hepatitis C Virus Infection. Mol Diagn Ther. 2015;19:213-20 pubmed publisher
    ..Serum miR-199a and miR-16 could be used as potential indicators of the progress of HCC. ..
  62. Williams K, Renthal N, Gerard R, Mendelson C. The microRNA (miR)-199a/214 cluster mediates opposing effects of progesterone and estrogen on uterine contractility during pregnancy and labor. Mol Endocrinol. 2012;26:1857-67 pubmed publisher
    ..Together, these findings identify miR-199a-3p/miR-214 as important regulators of myometrial contractility and provide new insight into strategies to prevent preterm birth. ..
  63. Byrnes K, Phatak P, Mansour D, Xiao L, Zou T, Rao J, et al. Overexpression of miR-199a-5p decreases esophageal cancer cell proliferation through repression of mitogen-activated protein kinase kinase kinase-11 (MAP3K11). Oncotarget. 2016;7:8756-70 pubmed publisher
    ..These findings suggest that miR-199a-5p acts as a tumor suppressor in esophageal cancer cells and that its downregulation contributes to enhanced cellular proliferation by targeting MAP3K11. ..
  64. Dai B, Geng L, Wang Y, Sui C, Xie F, Shen R, et al. microRNA-199a-5p protects hepatocytes from bile acid-induced sustained endoplasmic reticulum stress. Cell Death Dis. 2013;4:e604 pubmed publisher
    ..On the basis of these findings, we also suggest that the miRNA miR-199a-5p is a potential target for clinical approaches aiming to protect hepatocytes in liver disease...
  65. Li S, Wang Z, Mi X, Liu L, Tan Y. MiR-199a/b-3p suppresses migration and invasion of breast cancer cells by downregulating PAK4/MEK/ERK signaling pathway. IUBMB Life. 2015;67:768-77 pubmed publisher
    ..Thus, miR-199a/b-3p functions as a tumor suppressor and has an important role in breast cancer metastasis through PAK4/MEK/ERK signaling pathway. ..
  66. Li W, Wang H, Zhang J, Zhai L, Chen W, Zhao C. miR-199a-5p regulates ?1 integrin through Ets-1 to suppress invasion in breast cancer. Cancer Sci. 2016;107:916-23 pubmed publisher
  67. Mizuno S, Bogaard H, Gomez Arroyo J, Alhussaini A, Kraskauskas D, Cool C, et al. MicroRNA-199a-5p is associated with hypoxia-inducible factor-1? expression in lungs from patients with COPD. Chest. 2012;142:663-672 pubmed publisher
    ..These data suggest that miR-34a and miR-199a-5p contribute to the pathogenesis of COPD, and these miRNAs may also affect the HIF-1?-dependent lung structure maintenance program. ..
  68. Peng W, Chen Z, Wang L, Wang Z, Li J. MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation. Genet Mol Res. 2013;12:3038-47 pubmed publisher
  69. Baumgarten A, Bang C, Tschirner A, Engelmann A, Adams V, von Haehling S, et al. TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy. Int J Cardiol. 2013;168:1447-52 pubmed publisher
    ..The TWIST1/miR-199/214 axis is down-regulated in dilated cardiomyopathy, which is likely to play a role in the increased activity of the UPS. This may contribute to the loss of cardiac mass during dilatation of the heart. ..
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    ..SNHG12 functioned as an endogenous sponge for miR-199a/b-5p to regulate the expression of MLK3 and affect the NF-κB pathway. SNHG12 may serve as a valuable biomarker and a potential therapeutic target for HCC. ..
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    ..In gastric cancer tissue, miRNA-199a-3p was expressed in the cytoplasm of tumor cells. miRNA-199a-3p in plasma could be a novel potential diagnostic biomarker for gastric cancer detection. ..
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    ..Therefore, this signaling pathway may represent an important target for breast cancers with over-activation of the IGF-IR axis. ..
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    ..In summary, HCMV infection of endothelial cells upregulates miR-199a-5p expression and enhances cell migration and tube formation through downregulation of SIRT1/eNOS by miR-199a-5p. ..
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    ..Our data suggest that altered levels of circulating miRNAs might have great potential to serve as novel, non-invasive biomarkers for osteosarcoma. ..
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    ..This study proposes miR-199a-5p and miR-375 as contributors to CTX resistance in colon cancer and suggests a novel approach based on miRNAs as tools for the therapy of this tumor. ..