Gene Symbol: MIR185
Description: microRNA 185
Alias: MIRN185, miR-185
Species: human
Products:     MIR185

Top Publications

  1. Akçakaya P, Ekelund S, Kolosenko I, Caramuta S, Ozata D, Xie H, et al. miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer. Int J Oncol. 2011;39:311-8 pubmed publisher
    ..001 and 0.028, respectively) and metastasis (p=0.007 and 0.036, respectively) in colorectal cancer. Our findings suggest the potential prognostic values of these miRNAs for predicting clinical outcome after surgery. ..
  2. Xiang Y, Ma N, Wang D, Zhang Y, Zhou J, Wu G, et al. MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine. Oncogene. 2014;33:378-86 pubmed publisher
    ..These molecules may serve as potential epigenetic therapeutic targets in other cancers. ..
  3. Yoon J, Choi Y, Choi W, Ashktorab H, Smoot D, Nam S, et al. GKN1-miR-185-DNMT1 axis suppresses gastric carcinogenesis through regulation of epigenetic alteration and cell cycle. Clin Cancer Res. 2013;19:4599-610 pubmed publisher
    ..Thus, the loss of GKN1 function contributes to malignant transformation and proliferation of gastric epithelial cells in gastric carcinogenesis. ..
  4. de la Morena M, Eitson J, Dozmorov I, Belkaya S, Hoover A, Anguiano E, et al. Signature MicroRNA expression patterns identified in humans with 22q11.2 deletion/DiGeorge syndrome. Clin Immunol. 2013;147:11-22 pubmed publisher
    ..In summary, microRNA profiling of chromosome 22q11.2 deletion syndrome/DiGeorge patients revealed a signature microRNA expression pattern distinct from normal controls with clinical relevance. ..
  5. Imam J, Buddavarapu K, Lee Chang J, Ganapathy S, Camosy C, Chen Y, et al. MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers. Oncogene. 2010;29:4971-9 pubmed publisher
    ..Together, our findings suggest that the altered expression of the novel tumor suppressor miR-185 may be one of the central events that leads to dysregulation of oncogenic protein Six1 in human cancers. ..
  6. Maciel Dominguez A, Swan D, Ford D, Hesketh J. Selenium alters miRNA profile in an intestinal cell line: evidence that miR-185 regulates expression of GPX2 and SEPSH2. Mol Nutr Food Res. 2013;57:2195-205 pubmed publisher
    ..In the case of SEPHS2 this may contribute to maintaining selenoprotein synthesis. The data indicate that micronutrient supply can regulate the cell miRNA expression profile. ..
  7. Tang H, Wang Z, Liu X, Liu Q, Xu G, Li G, et al. LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway. Curr Cancer Drug Targets. 2012;12:1032-42 pubmed
    ..LRRC4 and miR-185 may also be good prognostic markers and therapeutic targets in glioma. ..
  8. Takahashi Y, Forrest A, Maeno E, Hashimoto T, Daub C, Yasuda J. MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines. PLoS ONE. 2009;4:e6677 pubmed publisher
    ..Especially for miR-107, a large number of down-regulated genes are annotated with the gene ontology term 'cell cycle'. Our results suggest that these miRNAs may contribute to regulate cell cycle in human malignant tumors. ..
  9. Li Q, Wang J, He Y, Feng C, Zhang X, Sheng J, et al. MicroRNA-185 regulates chemotherapeutic sensitivity in gastric cancer by targeting apoptosis repressor with caspase recruitment domain. Cell Death Dis. 2014;5:e1197 pubmed publisher
    ..Taken together, our results reveal that RUNX3, miR-185 and ARC regulate the sensitivity of gastric cancer cells to chemotherapy. ..

More Information


  1. Zhang Z, Tang H, Wang Z, Zhang B, Liu W, Lu H, et al. MiR-185 targets the DNA methyltransferases 1 and regulates global DNA methylation in human glioma. Mol Cancer. 2011;10:124 pubmed publisher
    ..These comprehensive data may provide new insights into the epigenetic pathogenesis of human gliomas. ..
  2. Liu M, Lang N, Chen X, Tang Q, Liu S, Huang J, et al. miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells. Cancer Lett. 2011;301:151-60 pubmed publisher
    ..Thus, miR-185 is a negative regulator of RhoA and Cdc42 and their cellular activities, and could inhibit proliferation and invasion of colorectal cancer cells. ..
  3. Yang M, Liu W, Pellicane C, Sahyoun C, Joseph B, Gallo Ebert C, et al. Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake. J Lipid Res. 2014;55:226-38 pubmed publisher
    ..Thus, a novel axis regulating cholesterol homeostasis exists that exploits miR-185-dependent regulation of SREBP-2 and requires SREBP-1c for function. ..
  4. Bao L, Fu X, Si M, Wang Y, Ma R, Ren X, et al. MicroRNA-185 targets SOCS3 to inhibit beta-cell dysfunction in diabetes. PLoS ONE. 2015;10:e0116067 pubmed publisher
    ..MiR-185 plays an important role in the regulation of insulin secretion and β-cell growth in diabetes. Restoration of miR-185 expression may serve a potentially promising and efficient therapeutic approach for diabetes. ..
  5. Hou J, Liu L, Zhu Q, Wu Y, Tian B, Cui L, et al. MicroRNA-185 inhibits angiogenesis in human microvascular endothelial cells through targeting stromal interaction molecule 1. Cell Biol Int. 2016;40:318-28 pubmed publisher
    ..MicroRNA-185 acted as a negative regulator of angiogenesis in microvascular endothelial cells through downregulation of the STIM1 protein. ..
  6. Zou Q, Wu H, Fu F, Yi W, Pei L, Zhou M. RKIP suppresses the proliferation and metastasis of breast cancer cell lines through up-regulation of miR-185 targeting HMGA2. Arch Biochem Biophys. 2016;610:25-32 pubmed publisher
    ..Our findings newly described RKIP/miR-185 to HMGA2 link and provided a potential mechanism for breast cancer cell growth and invasion. It may illustrate the potential therapeutic utility of signaling pathway signatures. ..
  7. Cai X, Lu S, Zhang Z, Gonzalez C, Damania B, Cullen B. Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc Natl Acad Sci U S A. 2005;102:5570-5 pubmed
    ..We hypothesize that these viral miRNAs play a critical role in the establishment and/or maintenance of KSHV latent infection in vivo and, hence, in KSHV-induced oncogenesis. ..
  8. Jiang H, Zhang J, Du Y, Jia X, Yang F, Si S, et al. microRNA-185 modulates low density lipoprotein receptor expression as a key posttranscriptional regulator. Atherosclerosis. 2015;243:523-32 pubmed publisher
  9. Qadir X, Han C, Lu D, Zhang J, Wu T. miR-185 inhibits hepatocellular carcinoma growth by targeting the DNMT1/PTEN/Akt pathway. Am J Pathol. 2014;184:2355-64 pubmed publisher
    ..Thus, reactivation or induction of miR-185 may represent a novel therapeutic strategy for HCC treatment. ..
  10. Wang J, He J, Su F, Ding N, Hu W, Yao B, et al. Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition. Cell Death Dis. 2013;4:e699 pubmed publisher
  11. Li S, Su S, Liu J. Differential Regulation of microRNAs in Patients with Ischemic Stroke. Curr Neurovasc Res. 2015;12:214-21 pubmed
  12. Lei G, Kline H, Lee C, Wilkes D, Zhang C. Regulation of Collagen V Expression and Epithelial-Mesenchymal Transition by miR-185 and miR-186 during Idiopathic Pulmonary Fibrosis. Am J Pathol. 2016;186:2310-6 pubmed publisher
  13. Forstner A, Basmanav F, Mattheisen M, Böhmer A, Hollegaard M, Janson E, et al. Investigation of the involvement of MIR185 and its target genes in the development of schizophrenia. J Psychiatry Neurosci. 2014;39:386-96 pubmed
    ..The minimal 1.5 megabase deletion contains MIR185, which encodes microRNA 185. We determined miR-185 expression in embryonic and adult mouse brains...
  14. Belkaya S, Murray S, Eitson J, de la Morena M, Forman J, van Oers N. Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1. J Biol Chem. 2013;288:30752-62 pubmed publisher
    ..2 deletion syndrome patients. Our findings indicate that miR-185 regulates T cell development through its targeting of several mRNAs including Mzb1. ..
  15. Fan X, Mao Z, He D, Liao C, Jiang X, Lei N, et al. Expression of somatostatin receptor subtype 2 in growth hormone-secreting pituitary adenoma and the regulation of miR-185. J Endocrinol Invest. 2015;38:1117-28 pubmed publisher
    ..MiR-185 enhanced the cell proliferation and inhibited the apoptosis of GH3 cells. ..
  16. Ma X, Shen D, Li H, Zhang Y, Lv X, Huang Q, et al. MicroRNA-185 inhibits cell proliferation and induces cell apoptosis by targeting VEGFA directly in von Hippel-Lindau-inactivated clear cell renal cell carcinoma. Urol Oncol. 2015;33:169.e1-11 pubmed publisher
    ..Our results suggest that the miR-185, as a tumor suppressor, plays a pivotal role by inhibiting VEGFA in VHL-inactivated ccRCC. ..
  17. Li G, Wang Y, Liu Y, Su Z, Liu C, Ren S, et al. miR-185-3p regulates nasopharyngeal carcinoma radioresistance by targeting WNT2B in vitro. Cancer Sci. 2014;105:1560-8 pubmed publisher
    ..We concluded that miR-185-3p contributed to the radioresistance of NPC via modulation of WNT2B expression in vitro. ..
  18. Venza I, Visalli M, Beninati C, Benfatto S, Teti D, Venza M. IL-10Rα expression is post-transcriptionally regulated by miR-15a, miR-185, and miR-211 in melanoma. BMC Med Genomics. 2015;8:81 pubmed publisher
    ..Our results support a key role of IL-10Rα in the development and progression of melanoma and suggest that the IL-10/IL-10 receptor system may become a new therapeutic target for melanoma treatment. ..
  19. Tang H, Liu P, Yang L, Xie X, Ye F, Wu M, et al. miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer. Mol Cancer Ther. 2014;13:3185-97 pubmed publisher
    ..Our data suggest that miR-185 functions as a tumor suppressor in TNBC development. It is a promising prognostic biomarker and potential therapeutic target for TNBC. ..
  20. Yuan H, Zhang J, Kong W, Liu Y, Lin Z, Wang W, et al. Elevated microRNA-185 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in clear cell renal cell carcinoma. Tumour Biol. 2014;35:12757-63 pubmed publisher
    ..However, further investigation should be performed to analyze the prognostic value of miRNA-185 in RCC. ..
  21. Jiang C, Ruan Y, Wang X, Zhao W, Jiang Q, Jing Y, et al. MiR-185 attenuates androgen receptor function in prostate cancer indirectly by targeting bromodomain containing 8 isoform 2, an androgen receptor co-activator. Mol Cell Endocrinol. 2016;427:13-20 pubmed publisher
    ..In addition to suppression of AR expression, miR-185 can attenuate AR function indirectly by suppressing BRD8 ISO2. MiR-185 and BRD8 ISO2 may be possible therapeutic targets for PCa treatment. ..
  22. Qu F, Cui X, Hong Y, Wang J, Li Y, Chen L, et al. MicroRNA-185 suppresses proliferation, invasion, migration, and tumorigenicity of human prostate cancer cells through targeting androgen receptor. Mol Cell Biochem. 2013;377:121-30 pubmed publisher
    ..Our findings suggest that miR-185 could function as a tumor-suppressor gene in CaP by directly targeting AR, and act as a potential therapeutic target for CaP. ..
  23. Li X, Chen Y, Josson S, Mukhopadhyay N, Kim J, Freeman M, et al. MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells. PLoS ONE. 2013;8:e70987 pubmed publisher
    ..Restoration of miR-185 and 342 led to caspase-dependent apoptotic death in prostate cancer cells. The newly identified miRNAs, miR-185 and 342, represent a novel targeting mechanism for prostate cancer therapy. ..
  24. Xu J, Ai Q, Cao H, Liu Q. MiR-185-3p and miR-324-3p Predict Radiosensitivity of Nasopharyngeal Carcinoma and Modulate Cancer Cell Growth and Apoptosis by Targeting SMAD7. Med Sci Monit. 2015;21:2828-36 pubmed publisher
    ..MiR-185-3p and miR-324-3p can modulate NPC cell growth and apoptosis, at least partly through targeting SMAD7. ..
  25. Liu C, Chen Z, Hu X, Wang L, Li C, Xue J, et al. MicroRNA-185 downregulates androgen receptor expression in the LNCaP prostate carcinoma cell line. Mol Med Rep. 2015;11:4625-32 pubmed publisher
    ..Therefore, the results of the present study suggested that miR‑185 may be a potential negative modulator of AR‑mediated signaling and may act as a tumor suppressor in prostate cancer cells. ..
  26. Dong Xu W, Jia L, Su Juan Z. MicroRNA-185 is a novel tumor suppressor by negatively modulating the Wnt/?-catenin pathway in human colorectal cancer. Indian J Cancer. 2015;52 Suppl 3:E182-5 pubmed publisher
    ..Taken together, these results suggested that miR-185 exerts its tumor suppressor activities probably through a negative modulation of the Wnt/?-catenin pathway. ..
  27. Li M, Wang Q, Liu S, Zhang J, Ju W, Quan M, et al. MicroRNA-185-5p mediates regulation of SREBP2 expression by hepatitis C virus core protein. World J Gastroenterol. 2015;21:4517-25 pubmed publisher
    ..HCV core protein disturbs the cholesterol homeostasis in HepG2 cells via the SREBP2 pathway; miR-185-5p is involved in the regulation of SREBP2 by the core protein. ..
  28. La Sala L, Cattaneo M, De Nigris V, Pujadas G, Testa R, Bonfigli A, et al. Oscillating glucose induces microRNA-185 and impairs an efficient antioxidant response in human endothelial cells. Cardiovasc Diabetol. 2016;15:71 pubmed publisher
    ..Glucose oscillations may exert more deleterious effects on the endothelium than high glucose, likely due to an impaired response of GPx-1, coupled by the upregulation of miR-185. ..
  29. Deng L, Wang X, Jiang L, Yang J, Zhou X, Lu Z, et al. Modulation of miR-185-5p expression by EBV-miR-BART6 contributes to developmental differences in ABCG4 gene expression in human megakaryocytes. Int J Biochem Cell Biol. 2016;81:105-111 pubmed publisher
    ..These data suggest a new paradigm to explain the mechanisms underlying ITP, involving the regulation of megakaryocytopoiesis by viral microRNAs through the intronic hsa-microRNA. ..
  30. Li S, Ma Y, Hou X, Liu Y, Li K, Xu S, et al. MiR-185 acts as a tumor suppressor by targeting AKT1 in non-small cell lung cancer cells. Int J Clin Exp Pathol. 2015;8:11854-62 pubmed
    ..Collectively, we conclude that miR-185 has a critical function by blocking AKT1 in NSCLC cells, and it may be a novel therapeutic agent for miRNA based NSCLC therapy. ..
  31. Zhou L, Liu S, Han M, Feng S, Liang J, Li Z, et al. MicroRNA-185 induces potent autophagy via AKT signaling in hepatocellular carcinoma. Tumour Biol. 2017;39:1010428317694313 pubmed publisher
    ..Binding site mutations eliminated microRNA 185 responsiveness. Our findings demonstrate a new role of microRNA 185 as a key regulator of hepatocellular carcinoma via autophagy by dysregulation of AKT1 pathway. ..
  32. Liao J, Lu H. Autoregulatory suppression of c-Myc by miR-185-3p. J Biol Chem. 2011;286:33901-9 pubmed publisher
    ..Thus, our results unveil miR-185-3p as the first miRNA that monitors c-Myc levels via an autoregulatory feedback mechanism in response to serum stimulation. ..
  33. Qiu F, Xiong J, Deng J, Xiang X. TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185. Int J Clin Exp Pathol. 2015;8:5053-61 pubmed
    ..Over-expression of miR-185 in MGC803 cells inhibited TRIM29 expression and activity of Wnt/β-catenin signaling. Taken together, our results suggest that TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185. ..
  34. Jing R, Chen W, Wang H, Ju S, Cong H, Sun B, et al. Plasma miR-185 is decreased in patients with esophageal squamous cell carcinoma and might suppress tumor migration and invasion by targeting RAGE. Am J Physiol Gastrointest Liver Physiol. 2015;309:G719-29 pubmed publisher
    ..73 (95% CI 0.604-0.855). In conclusion, our findings shed novel light on the role of miR-185/RAGE in ESCC metastasis, and plasma miR-185 has potential as a novel diagnostic biomarker in ESCC. ..
  35. Yu M, Liang W, Wen S, Zhao T, Zhu M, Li H, et al. EphB2 contributes to human naive B-cell activation and is regulated by miR-185. FASEB J. 2014;28:3609-17 pubmed publisher
    ..Our study first suggested that EphB2 was involved in human naive B cell activation through Src-p65 and Notch1 signaling pathways and could be regulated by miR-185. ..
  36. Lu Z, Lu L, Tao K, Chen D, Xia Q, Weng J, et al. MicroRNA-185 suppresses growth and invasion of colon cancer cells through inhibition of the hypoxia‑inducible factor-2α pathway in vitro and in vivo. Mol Med Rep. 2014;10:2401-8 pubmed publisher
  37. Wang L, Jia X, Jiang H, Du Y, Yang F, Si S, et al. MicroRNAs 185, 96, and 223 repress selective high-density lipoprotein cholesterol uptake through posttranscriptional inhibition. Mol Cell Biol. 2013;33:1956-64 pubmed publisher
  38. Tan Z, Jiang H, Wu Y, Xie L, Dai W, Tang H, et al. miR-185 is an independent prognosis factor and suppresses tumor metastasis in gastric cancer. Mol Cell Biochem. 2014;386:223-31 pubmed publisher
    ..It is also a potential therapeutic tool to improve clinical outcomes in the above disease. ..
  39. Zhi Q, Zhu J, Guo X, He S, Xue X, Zhou J, et al. Metastasis-related miR-185 is a potential prognostic biomarker for hepatocellular carcinoma in early stage. Biomed Pharmacother. 2013;67:393-8 pubmed publisher
    ..05). Therefore, miR-185 might be an effective and sensitive biomarker of HCC in early stage, and the upregulation of miR-185 might be considered to be a potentially important molecular treatment strategy for patients with HCC. ..
  40. Zhang Z, Liu X, Feng B, Liu N, Wu Q, Han Y, et al. STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer. Oncogene. 2015;34:4808-20 pubmed publisher
    ..This novel miR-185-STIM1 axis promotes CRC metastasis and may be a candidate biomarker for prognosis and a target for new therapies. ..
  41. Wang R, Tian S, Wang H, Chu D, Cao J, Xia H, et al. MiR-185 is involved in human breast carcinogenesis by targeting Vegfa. FEBS Lett. 2014;588:4438-47 pubmed
    ..Additionally, Vegfa expression was found to be high in human breast cancer tissues. Thus, miR-185-mediated Vegfa targeting may be involved in breast cancer formation. ..
  42. Uğurel E, Şehitoğlu E, Tüzün E, Kürtüncü M, Çoban A, Vural B. Increased complexin-1 and decreased miR-185 expression levels in Behçet's disease with and without neurological involvement. Neurol Sci. 2016;37:411-6 pubmed publisher
    ..Significant expression alterations of CPLX1 in BD and NBD patients suggest that this molecule has a proinflammatory action. The putative role of CPLX1 in BD pathogenesis remains to be further studied. ..
  43. Tang H, Liu Q, Liu X, Ye F, Xie X, Xie X, et al. Plasma miR-185 as a predictive biomarker for prognosis of malignant glioma. J Cancer Res Ther. 2015;11:630-4 pubmed publisher
    ..These findings suggest that plasma miR-185 has become potential biomarkers for glioma and may be useful in clinical management for glioma patients. ..
  44. Xiao K, Luo X, Wang X, Gao Z. MicroRNA?185 regulates transforming growth factor??1 and collagen?1 in hypertrophic scar fibroblasts. Mol Med Rep. 2017;15:1489-1496 pubmed publisher
    ..However, above all, miR?185 might serve as a potential therapeutic approach for the treatment of HS. ..
  45. Huang Q, Sun Y, Ma X, Gao Y, Li X, Niu Y, et al. Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma. Nat Commun. 2017;8:918 pubmed publisher
    ..Here the authors show how androgen receptor expression influences the metastatic route through the regulation of miR-185 and VEGF isoforms. ..
  46. Zhang D, Lee H, Cao Y, Dela Cruz C, Jin Y. miR-185 mediates lung epithelial cell death after oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2016;310:L700-10 pubmed publisher
    ..Taken together, hyperoxia-induced miR-185 in lung epithelial cells contributes to oxidative stress-associated epithelial cell death through enhanced DNA damage and modulation of 14-3-3δ pathways. ..
  47. Wang S, Tang L, Zhou Q, Lu D, Duan W, Chen C, et al. miR-185/P2Y6 Axis Inhibits Angiotensin II-Induced Human Aortic Vascular Smooth Muscle Cell Proliferation. DNA Cell Biol. 2017;36:377-385 pubmed publisher