Gene Symbol: MIR182
Description: microRNA 182
Alias: MIRN182, miRNA182
Species: human
Products:     MIR182

Top Publications

  1. Pignot G, Cizeron Clairac G, Vacher S, Susini A, Tozlu S, Vieillefond A, et al. microRNA expression profile in a large series of bladder tumors: identification of a 3-miRNA signature associated with aggressiveness of muscle-invasive bladder cancer. Int J Cancer. 2013;132:2479-91 pubmed publisher
    ..05). Our results suggested a promising individual prognostic value of these new markers. ..
  2. Chen X, Zhang H, Wu T, Sang W, Ruan Z. Down-regulation of NAMPT expression by miR-182 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation. Int J Biochem Cell Biol. 2013;45:292-8 pubmed publisher
    ..Our results suggest that strategies to augment NAMPT protein expression by down-regulation of miR-182 may have therapeutic benefits to prevent HIV-1 replication...
  3. Zhang L, Liu T, Huang Y, Liu J. microRNA-182 inhibits the proliferation and invasion of human lung adenocarcinoma cells through its effect on human cortical actin-associated protein. Int J Mol Med. 2011;28:381-8 pubmed publisher
    ..In conclusion, endogenous mature miR-182 expression may have an important role in the pathogenesis of lung cancer through its interference with the target gene CTTN by epigenetic modification. ..
  4. Yan D, Dong X, Chen X, Yao S, Wang L, Wang J, et al. Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2. PLoS ONE. 2012;7:e40967 pubmed publisher
    ..Our results demonstrated that miR-182, a p53 dependent miRNA, suppressed the expression of MITF, BCL2, cyclin D2 and functioned as a potent tumor suppressor in uveal melanoma cells. ..
  5. Qu Y, Li W, Hellem M, Rostad K, Popa M, McCormack E, et al. MiR-182 and miR-203 induce mesenchymal to epithelial transition and self-sufficiency of growth signals via repressing SNAI2 in prostate cells. Int J Cancer. 2013;133:544-55 pubmed publisher
    ..We conclude that miR-182 and miR-203 induce MET features and growth factor independent growth via repressing SNAI2 in prostate cells. Our findings shed new light on the roles of miR-182/203 in cancer related processes. ..
  6. Moskwa P, Buffa F, Pan Y, Panchakshari R, Gottipati P, Muschel R, et al. miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell. 2011;41:210-20 pubmed publisher
    ..Together these results suggest that miR-182-mediated downregulation of BRCA1 impedes DNA repair and may impact breast cancer therapy. ..
  7. Wang J, Li J, Shen J, Wang C, Yang L, Zhang X. MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma. BMC Cancer. 2012;12:227 pubmed publisher
    ..miR-182 could promote metastasis of HCC and inhibit the expression of MTSS1. miR-182 and MTSS1 are potential prognostic markers and/or therapeutic targets in HCC. ..
  8. Jiang L, Mao P, Song L, Wu J, Huang J, Lin C, et al. miR-182 as a prognostic marker for glioma progression and patient survival. Am J Pathol. 2010;177:29-38 pubmed publisher
    ..Taken together, our results suggest that miR-182 could be a valuable marker of glioma progression and that high miR-182 expression is associated with poor overall survival in patients with malignant glioma. ..
  9. Yang W, Chen P, Hsu T, Fu T, Su W, Liaw H, et al. Sp1-mediated microRNA-182 expression regulates lung cancer progression. Oncotarget. 2014;5:740-53 pubmed
    ..This stimulates proliferation and tumor growth. In the late stages, Sp1 and miR-182 decline, thus increasing FOXO3 expression, which leads to lung metastasis. ..

More Information


  1. Liu H, Du L, Wen Z, Yang Y, Li J, Wang L, et al. Up-regulation of miR-182 expression in colorectal cancer tissues and its prognostic value. Int J Colorectal Dis. 2013;28:697-703 pubmed publisher
  2. Liu Z, Liu J, Segura M, Shao C, Lee P, Gong Y, et al. MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma. J Pathol. 2012;228:204-15 pubmed publisher
    ..Our findings suggest that miR-182 dysregulation confers powerful oncogenic potential in the tumourigenesis of HG-SOC. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  3. Amodeo V, Bazan V, Fanale D, Insalaco L, Caruso S, Cicero G, et al. Effects of anti-miR-182 on TSP-1 expression in human colon cancer cells: there is a sense in antisense?. Expert Opin Ther Targets. 2013;17:1249-61 pubmed publisher
    ..Moreover, anti-miR-182 exerts a transcriptional regulatory mechanism of tsp-1 modulating Egr-1 and Sp-1 function. Anti-miR-182 could be used to restore TSP-1 expression in order to contrast angiogenic and invasive events in CRC. ..
  4. McMillen B, Aponte M, Liu Z, Helenowski I, Scholtens D, Buttin B, et al. Expression analysis of MIR182 and its associated target genes in advanced ovarian carcinoma. Mod Pathol. 2012;25:1644-53 pubmed publisher
    BRCA1/BRCA2 mutations are common and the hallmarks of high-grade serous ovarian carcinoma. We found that MIR182, a negative BRCA1 regulator, is significantly overexpressed in high-grade serous ovarian carcinoma...
  5. Ning F, Wang F, Li M, Yu Z, Hao Y, Chen S. MicroRNA-182 modulates chemosensitivity of human non-small cell lung cancer to cisplatin by targeting PDCD4. Diagn Pathol. 2014;9:143 pubmed publisher
    ..The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1793467320130186. ..
  6. Mihelich B, Khramtsova E, Arva N, Vaishnav A, Johnson D, Giangreco A, et al. miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells. J Biol Chem. 2011;286:44503-11 pubmed publisher
    ..Individually or as a cluster, miR-183, -96, and -182 are overexpressed in other cancers too, implicating this miR cluster in carcinogenesis. ..
  7. Hirata H, Ueno K, Shahryari V, Deng G, Tanaka Y, Tabatabai Z, et al. MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer. PLoS ONE. 2013;8:e55502 pubmed publisher
    ..Also knock down of miR-182-5p in order to increase expression of tumor suppressor genes FOXF2, RECK and MTSS1 may be of therapeutic benefit in prostate cancer treatment. ..
  8. Song L, Liu L, Wu Z, Li Y, Ying Z, Lin C, et al. TGF-? induces miR-182 to sustain NF-?B activation in glioma subsets. J Clin Invest. 2012;122:3563-78 pubmed publisher
    ..These findings uncover a plausible mechanism for sustained NF-?B activation in malignant gliomas and may suggest a new target for clinical intervention in human cancer. ..
  9. Pizzini S, Bisognin A, Mandruzzato S, Biasiolo M, Facciolli A, Perilli L, et al. Impact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis. BMC Genomics. 2013;14:589 pubmed publisher
    ..Using a large dataset of CRC miRNA and gene expression profiles, we describe the interplay of miRNA groups in regulating gene expression, which in turn affects modulated pathways that are important for tumor development. ..
  10. Segura M, Hanniford D, Menendez S, Reavie L, Zou X, Alvarez Diaz S, et al. Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc Natl Acad Sci U S A. 2009;106:1814-9 pubmed publisher
    ..Our data provide a mechanism for invasion and survival in melanoma that could prove applicable to metastasis of other cancers and suggest that miRNA silencing may be a worthwhile therapeutic strategy. ..
  11. Wang M, Wang Y, Zang W, Wang H, Chu H, Li P, et al. Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells. Tumour Biol. 2014;35:39-46 pubmed publisher
    ..These results suggest that in lung adenocarcinoma cells, miR-182 plays an oncogenic role as a direct negative regulator of PDCD4. ..
  12. Liu H, Wang Y, Li X, Zhang Y, Li J, Zheng Y, et al. Expression and regulatory function of miRNA-182 in triple-negative breast cancer cells through its targeting of profilin 1. Tumour Biol. 2013;34:1713-22 pubmed publisher
    ..Treatment strategies utilizing inhibition of miR-182 expression or overexpression of the PFN1 gene might benefit patients with TNBC...
  13. Wang Y, Guo R, Guo R, Sheng W, Yin L. MicroRNA-182 promotes cell growth, invasion, and chemoresistance by targeting programmed cell death 4 (PDCD4) in human ovarian carcinomas. J Cell Biochem. 2013;114:1464-73 pubmed publisher
    ..We conclude that in ovarian cancer cells, miR-182 acts as an oncogenic miRNA by directly and negatively regulating PDCD4. ..
  14. Tang T, Wong H, Gu W, Yu M, To K, Wang C, et al. MicroRNA-182 plays an onco-miRNA role in cervical cancer. Gynecol Oncol. 2013;129:199-208 pubmed publisher
    ..Our findings indicated that miR-182 plays an onco-miRNA role in cervical cancer and its alteration is associated with cervical cancer pathogenesis by disrupting cell proliferation. ..
  15. Lei R, Tang J, Zhuang X, Deng R, Li G, Yu J, et al. Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis. Oncogene. 2014;33:1287-96 pubmed publisher
    ..Hence, our data delineates the molecular pathway by which miR-182 promotes breast cancer invasion and metastasis, and may have important implication for the treatment of metastatic cancers. ..
  16. Cekaite L, Rantala J, Bruun J, Guriby M, Agesen T, Danielsen S, et al. MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer. Neoplasia. 2012;14:868-79 pubmed
    ..This study suggests that deregulated expression of miR-9, miR-31, and miR-182 during carcinogenesis plays a significant role in the development of colon cancer by promoting proliferation and tumor cell survival. ..
  17. Guttilla I, White B. Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem. 2009;284:23204-16 pubmed publisher
    ..We have identified a novel mechanism of FOXO1 regulation, and targeting of FOXO1 by microRNAs may contribute to transformation or maintenance of an oncogenic state in breast cancer cells. ..
  18. Hirata H, Ueno K, Shahryari V, Tanaka Y, Tabatabai Z, Hinoda Y, et al. Oncogenic miRNA-182-5p targets Smad4 and RECK in human bladder cancer. PLoS ONE. 2012;7:e51056 pubmed publisher
    ..In conclusion, our data suggests that miR-182-5p plays an important role as an oncogene by knocking down RECK and Smad4, resulting in activation of the Wnt-beta-catenin signaling pathway in bladder cancer. ..
  19. Kong W, Bai R, Liu T, Cai C, Liu M, Li X, et al. MicroRNA-182 targets cAMP-responsive element-binding protein 1 and suppresses cell growth in human gastric adenocarcinoma. FEBS J. 2012;279:1252-60 pubmed publisher
    ..These results indicate that miR-182 targets the CREB1 gene and suppresses gastric adenocarcinoma cell growth, suggesting that miR-182 shows tumor-suppressive activity in human gastric cancer. ..
  20. Sun Y, Fang R, Li C, Li L, Li F, Ye X, et al. Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro. Biochem Biophys Res Commun. 2010;396:501-7 pubmed publisher
    ..Taken together, these data have provided the first evidence of miRNA regulation of RGS17 expression in lung cancer. ..
  21. Li E, Ji P, Ouyang N, Zhang Y, Wang X, Rubin D, et al. Differential expression of miRNAs in colon cancer between African and Caucasian Americans: implications for cancer racial health disparities. Int J Oncol. 2014;45:587-94 pubmed publisher
    ..miRNAs may play a role in the differences between AA and CA colon cancer. Specifically, differences in miRNA expression levels of miR-182 may contribute to decreased survival in AA colon cancer patients. ..
  22. Zhang Y, Wang X, Wang Z, Tang H, Fan H, Guo Q. miR-182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer. Oncol Rep. 2015;33:2592-8 pubmed publisher
    ..miR-182-induced downregulation of FoxF2 partly accounts for increased activity of β-catenin signaling. Inhibition of miR-182 represents a potential strategy against CRC. ..
  23. Liu B, Liu Y, Zhao L, Pan Y, Shan Y, Li Y, et al. Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway. Mol Carcinog. 2017;56:2669-2680 pubmed publisher
    ..Taken together, miR-135b and miR-182 may reverse the resistance to 5-FU in CRC cells by targeting ST6GALNAC2 via PI3K/AKT pathway, which render potential chemotherapy targets for the treatment of CRC. ..
  24. Yang A, Ma J, Wu M, Qin W, Zhao B, Shi Y, et al. Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies. Leuk Lymphoma. 2012;53:2465-73 pubmed publisher
    ..These results demonstrate that miR-182 is involved in glucocorticoid resistance, via targeting of FOXO3A, and that restoration of miR-182 is a potentially promising therapeutic strategy in lymphoblastic malignancies. ..
  25. Chen Q, Yang L, Xiao Y, Zhu J, Li Z. Circulating microRNA-182 in plasma and its potential diagnostic and prognostic value for pancreatic cancer. Med Oncol. 2014;31:225 pubmed publisher
    ..001). Cox analysis indicated that it was an independent prognostic factor for OS and DFS. Our data suggest that circulating miR-182 may be a potential and useful noninvasive tumor marker for diagnosis and prognosis of pancreatic cancer. ..
  26. Wang L, Dong F, Reinach P, He D, Zhao X, Chen X, et al. MicroRNA-182 Suppresses HGF/SF-Induced Increases in Retinal Pigment Epithelial Cell Proliferation and Migration through Targeting c-Met. PLoS ONE. 2016;11:e0167684 pubmed publisher
    ..As ectopic miR-182 expression suppressed RPE cell proliferation and migration, strategies to selectively upregulate miR-182 expression in a clinical setting may provide a novel option to treat this disease. ..
  27. Li Y, Sun Y, Ren F, Li Y, Liu M, Liu H, et al. [Methylation Status of miR-182 Promoter in Lung Cancer Cell Lines]. Zhongguo Fei Ai Za Zhi. 2015;18:260-5 pubmed publisher
  28. Dodd R, Sachdeva M, Mito J, Eward W, Brigman B, Ma Y, et al. Myogenic transcription factors regulate pro-metastatic miR-182. Oncogene. 2016;35:1868-75 pubmed publisher
  29. Zhou J, Meng Y, Tian S, Chen J, Liu M, Zhuo M, et al. Comparative microRNA expression profiles of cynomolgus monkeys, rat, and human reveal that mir-182 is involved in T2D pathogenic processes. J Diabetes Res. 2014;2014:760397 pubmed publisher
    ..Therefore, miR-182 can be a biomarker in diagnosis of the potential T2D that has benefits for medical purpose. ..
  30. Xiao Y, Zhang L, Song Z, Guo C, Zhu J, Li Z, et al. Potential Diagnostic and Prognostic Value of Plasma Circulating MicroRNA-182 in Human Glioma. Med Sci Monit. 2016;22:855-62 pubmed
    ..034) and DFS (P=0.013). These results suggest that circulating miR-182 may be a potential noninvasive biomarker for the diagnosis and prognosis of human glioma. ..
  31. Modi S, Cavanaugh J, Shiraishi R, Alexander H, McCarthy K, Burmen B, et al. Performance of Clinical Screening Algorithms for Tuberculosis Intensified Case Finding among People Living with HIV in Western Kenya. PLoS ONE. 2016;11:e0167685 pubmed publisher
    ..National HIV programs should evaluate the feasibility of laboratory-based screening for TB, such as a single Xpert MTB/RIF test for all PLHIV, especially pregnant women, at enrollment in HIV services. ..
  32. Blaya D, Coll M, Rodrigo Torres D, Vila Casadesús M, Altamirano J, Llopis M, et al. Integrative microRNA profiling in alcoholic hepatitis reveals a role for microRNA-182 in liver injury and inflammation. Gut. 2016;65:1535-45 pubmed publisher
    ..AH is characterised by a deregulated miRNA profile, including miR-182, which is associated with disease severity and liver injury. These results highlight the potential of miRNAs as therapeutic targets and biomarkers in AH. ..
  33. Marzec Kotarska B, Cybulski M, Kotarski J, Ronowicz A, Tarkowski R, Polak G, et al. Molecular bases of aberrant miR-182 expression in ovarian cancer. Genes Chromosomes Cancer. 2016;55:877-89 pubmed publisher
    ..Deletion of the PRDM5 locus may play a supportive role in miR-182 overexpression in EOC. miR-182 is an unfavorable prognostic factor in EOC. © 2016 Wiley Periodicals, Inc. ..
  34. Chiang C, Hou M, Hung W. Up-regulation of miR-182 by ?-catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK. Biochim Biophys Acta. 2013;1830:3067-76 pubmed publisher
    ..Our data demonstrate for the first time that miR-182 expression is controlled by ?-catenin. In addition, we identify a new miR-182 target RECK which is important for miR-182-induced tumorigenesis. ..
  35. Du C, Weng X, Hu W, Lv Z, Xiao H, Ding C, et al. Hypoxia-inducible MiR-182 promotes angiogenesis by targeting RASA1 in hepatocellular carcinoma. J Exp Clin Cancer Res. 2015;34:67 pubmed publisher
    ..Besides, RASA1 was also decreased in the hypoxia HCC cells while the inhibition of miR-182 partially restored the level of RASA1. Our data showed that hypoxia regulated the expression of miR-182 and RASA1 to promote HCC angiogenesis. ..
  36. Xu X, Wu J, Li S, Hu Z, Xu X, Zhu Y, et al. Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT/FOXO3a signaling pathway. Mol Cancer. 2014;13:109 pubmed publisher
    ..These findings highlight an important role for miR-182-5p in the pathogenesis of RCC, and restoration of miR-182-5p could be considered as a potential therapeutic strategy for RCC therapy. ..
  37. Zhang W, Qian P, Zhang X, Zhang M, Wang H, Wu M, et al. Autocrine/Paracrine Human Growth Hormone-stimulated MicroRNA 96-182-183 Cluster Promotes Epithelial-Mesenchymal Transition and Invasion in Breast Cancer. J Biol Chem. 2015;290:13812-29 pubmed publisher
  38. Liu Y, Bailey J, Helwa I, Dismuke W, Cai J, Drewry M, et al. A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium. Invest Ophthalmol Vis Sci. 2016;57:4528-4535 pubmed publisher
    ..Only rs76481776 in MIR182 gene was associated with POAG after adjustment for multiple comparisons (odds ratio [OR] = 1...
  39. Zhan Y, Li X, Liang X, Li L, Cao B, Wang B, et al. MicroRNA-182 drives colonization and macroscopic metastasis via targeting its suppressor SNAI1 in breast cancer. Oncotarget. 2017;8:4629-4641 pubmed publisher
    ..Taking together, our findings describe the role of miR-182 in colonization and macrometastases in breast cancer for the first time, and provide a promise for diagnosis or therapy of breast cancer metastasis. ..
  40. Spitschak A, Meier C, Kowtharapu B, Engelmann D, Pützer B. MiR-182 promotes cancer invasion by linking RET oncogene activated NF-?B to loss of the HES1/Notch1 regulatory circuit. Mol Cancer. 2017;16:24 pubmed publisher
    ..This observation might open new possibilities to treat RET oncogene associated metastatic cancer. ..
  41. Huang W, Tian Y, Dong S, Cha Y, Li J, Guo X, et al. The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer. Oncol Rep. 2017;38:1402-1410 pubmed publisher
    ..In conclusion, SNHG3 promoted CRC progression via sponging miR-182-5p and upregulating c-Myc and its target genes. ..
  42. Olivieri F, Ahtiainen M, Lazzarini R, Pöllänen E, Capri M, Lorenzi M, et al. Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-223 expressions: a study on postmenopausal monozygotic twin pairs. Aging Cell. 2014;13:850-61 pubmed publisher
  43. Sun L, Bai Y, Zhao R, Sun T, Cao R, Wang F, et al. Oncological miR-182-3p, a Novel Smooth Muscle Cell Phenotype Modulator, Evidences From Model Rats and Patients. Arterioscler Thromb Vasc Biol. 2016;36:1386-97 pubmed publisher
    ..miR-182-3p is a novel SMC phenotypic modulator by targeting MYADM. ..
  44. Saus E, Soria V, Escaramis G, Vivarelli F, Crespo J, Kagerbauer B, et al. Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia. Hum Mol Genet. 2010;19:4017-25 pubmed publisher
  45. Wei S, Bing Z, Yao Y, Master S, Gupta P. Higher Expression of miR-182 in Cytology Specimens of High-Grade Urothelial Cell Carcinoma: A Potential Diagnostic Marker. Acta Cytol. 2015;59:109-12 pubmed publisher
    ..Measuring miR-182 may provide a potential alternative or adjunct approach for screening high-grade UCC. ..
  46. Tang L, Chen F, Pang E, Zhang Z, Jin B, Dong W. MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer. Oncol Rep. 2015;33:1707-16 pubmed publisher
    ..The elucidation of the mechanisms of miR-182 targeting ANUBL1 in gastric cancer helps us to further understand the mechanism of gastric cancer initiation and progression. ..
  47. Visani M, de Biase D, Marucci G, Cerasoli S, Nigrisoli E, Bacchi Reggiani M, et al. Expression of 19 microRNAs in glioblastoma and comparison with other brain neoplasia of grades I-III. Mol Oncol. 2014;8:417-30 pubmed publisher
    ..This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different-grade neoplasia could be characterized by different expression of specific miRNAs. ..
  48. Rapti S, Kontos C, Papadopoulos I, Scorilas A. Enhanced miR-182 transcription is a predictor of poor overall survival in colorectal adenocarcinoma patients. Clin Chem Lab Med. 2014;52:1217-27 pubmed publisher
    ..006) and among metastasis-free patients (p=0.025). The increased levels of the oncogene-like miR-182 increase the risk for disease progression and predict poor overall survival for colorectal adenocarcinoma patients. ..
  49. Li Y, Zhang H, Li Y, Zhao C, Fan Y, Liu J, et al. MiR-182 inhibits the epithelial to mesenchymal transition and metastasis of lung cancer cells by targeting the Met gene. Mol Carcinog. 2017;: pubmed publisher
    ..miR-182 might suppress the EMT and metastasis via inactivation of Met/AKT/Snail in non-small cell lung cancer (NSCLC) cells, which implicates miR-182 may be useful as a new therapeutic target in NSCLC. ..
  50. Chen Z, Wu L, Lin Q, Shi J, Lin X, Shi L. Evaluation of miR-182/miR-100 Ratio for Diagnosis and Survival Prediction in Bladder Cancer. Arch Iran Med. 2016;19:645-51 pubmed publisher
    ..01). The miR-182/miR-100 ratio may serve as a novel promising biomarker for diagnosis and survival prediction in BCa. Further studies are needed to elucidate the role of miR-182/miR-100 ratio as a non?invasive diagnostic tool for BCa. ..
  51. Li Y, Chen S, Shan Z, Bi L, Yu S, Li Y, et al. miR-182-5p improves the viability, mitosis, migration, and invasion ability of human gastric cancer cells by down-regulating RAB27A. Biosci Rep. 2017;37: pubmed publisher
    ..miR-182-5p enhances the viability, mitosis, migration, and invasion of human GC cells by down-regulating RAB27A. ..
  52. El Sobky S, El Ekiaby N, Mekky R, Elemam N, Mohey Eldin M, El Sayed M, et al. Contradicting roles of miR-182 in both NK cells and their host target hepatocytes in HCV. Immunol Lett. 2016;169:52-60 pubmed publisher
    ..In addition to that, miR-182 was found to have a contradicting effect in both effector cell and its HCV-infected target cell regarding HCV replication. ..
  53. Li X, Hara T, Choi Y, Subramanian M, Francis P, Bilke S, et al. A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster. Mol Cell Biol. 2014;34:533-50 pubmed publisher
    ..Furthermore, we found that p21 forms a complex with ZEB1 at the miR-183-96-182 cluster promoter to inhibit transcriptional repression of this cluster by ZEB1, suggesting a reciprocal feedback loop. ..
  54. Zhang Q, Ren W, Huang B, Yi L, Zhu H. MicroRNA-183/182/96 cooperatively regulates the proliferation of colon cancer cells. Mol Med Rep. 2015;12:668-74 pubmed publisher
  55. Li G, Li M, Hu J, Lei R, Xiong H, Ji H, et al. The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. Oncogene. 2017;36:989-998 pubmed publisher
    ..Hence, our work suggests that the miR-182-PDK4 axis is a crucial regulator of cancer cell metabolism and a potential target for antitumor therapy. ..
  56. Yao J, Xu C, Fang Z, Li Y, Liu H, Wang Y, et al. Androgen receptor regulated microRNA miR-182-5p promotes prostate cancer progression by targeting the ARRDC3/ITGB4 pathway. Biochem Biophys Res Commun. 2016;474:213-219 pubmed publisher
  57. Levanon K, Sapoznik S, Bahar Shany K, Brand H, Shapira Frommer R, Korach J, et al. FOXO3a loss is a frequent early event in high-grade pelvic serous carcinogenesis. Oncogene. 2014;33:4424-32 pubmed publisher
    ..Our data strongly suggest FOXO3a as a possible target for clinical intervention. ..
  58. Qin J, Luo M, Qian H, Chen W. Upregulated miR-182 increases drug resistance in cisplatin-treated HCC cell by regulating TP53INP1. Gene. 2014;538:342-7 pubmed publisher
    ..These data suggest that miR-182/TP53INP1 signaling represents a novel pathway regulating chemoresistance, thus offering a new target for chemotherapy of HCC. ..
  59. Wurm A, Zjablovskaja P, Kardosova M, Gerloff D, Bräuer Hartmann D, Katzerke C, et al. Disruption of the C/EBP?-miR-182 balance impairs granulocytic differentiation. Nat Commun. 2017;8:46 pubmed publisher
    ..Here the authors show a negative feedback loop between C/EBP? and miR-182 and identify this miRNA as a marker of high-risk AML. ..
  60. Liu Y, Qiang W, Xu X, Dong R, Karst A, Liu Z, et al. Role of miR-182 in response to oxidative stress in the cell fate of human fallopian tube epithelial cells. Oncotarget. 2015;6:38983-98 pubmed publisher
  61. Wang S, Ji J, Song J, Li X, Han S, Lian W, et al. MicroRNA-182 promotes pancreatic cancer cell proliferation and migration by targeting ?-TrCP2. Acta Biochim Biophys Sin (Shanghai). 2016;48:1085-1093 pubmed
    ..The oncogenic effect of miR-182 and its reversal by ?-TrCP2 were confirmed in vivo This study suggests that ?-TrCP and miR-182 may be possible biomarkers and targets for early detection and treatment of pancreatic cancer. ..
  62. Liu R, Li J, Teng Z, Zhang Z, Xu Y. Overexpressed microRNA-182 promotes proliferation and invasion in prostate cancer PC-3 cells by down-regulating N-myc downstream regulated gene 1 (NDRG1). PLoS ONE. 2013;8:e68982 pubmed publisher
    ..In conclusion, our results suggest that miR-182 plays an important role in the proliferation of human prostate cancer cells by directly suppressing the tumor supressor gene NDRG1. We uncovered a new epigenetic regulation of NDRG1. ..
  63. Lu W, Lu T, Wei X. Downregulation of DNMT3a expression increases miR-182-induced apoptosis of ovarian cancer through caspase-3 and caspase-9-mediated apoptosis and DNA damage response. Oncol Rep. 2016;36:3597-3604 pubmed publisher
  64. Pillai S, Lo C, Liew V, Lalloz M, Smith R, Gopalan V, et al. MicroRNA 183 family profiles in pheochromocytomas are related to clinical parameters and SDHB expression. Hum Pathol. 2017;64:91-97 pubmed publisher
    ..To conclude, the findings indicate a role for miR-183 cluster members in the pathogenesis and clinical progression of pheochromocytoma. ..
  65. Assal R, El Tayebi H, Hosny K, Esmat G, Abdelaziz A. A pleiotropic effect of the single clustered hepatic metastamiRs miR-96-5p and miR-182-5p on insulin-like growth factor II, insulin-like growth factor-1 receptor and insulin-like growth factor-binding protein-3 in hepatocellular carcinoma. Mol Med Rep. 2015;12:645-50 pubmed publisher
    ..The present study revealed the pleiotropic impact of the single clustered hepatic metastamiRs miR-96-5p and miR-182-5p on IGF-1R, and an inducing effect on IGF-II and IGFBP-3 in hepatocellular carcinoma. ..
  66. Guo Y, Liao Y, Jia C, Ren J, Wang J, Li T. MicroRNA-182 promotes tumor cell growth by targeting transcription elongation factor A-like 7 in endometrial carcinoma. Cell Physiol Biochem. 2013;32:581-90 pubmed publisher
    ..miR-182 acts as an oncogenic miRNA in EC, promoting cell proliferation by targeting the tumor suppressor gene TCEAL7 and modulating the activity of its downstream effectors c-Myc, cyclin D1 and NF?B. ..
  67. Roa W, Brunet B, Guo L, Amanie J, Fairchild A, Gabos Z, et al. Identification of a new microRNA expression profile as a potential cancer screening tool. Clin Invest Med. 2010;33:E124 pubmed
    ..Future work will focus on the sensitivity of such miRNA expression profiles in screening sputum for lung cancer, which can be performed in real time. ..
  68. Liu J, Ma L, Li C, Zhang Z, Yang G, Zhang W. Tumor-targeting TRAIL expression mediated by miRNA response elements suppressed growth of uveal melanoma cells. Mol Oncol. 2013;7:1043-55 pubmed publisher
    ..Collectively, we constructed an MRE-directed TRAIL-expressing adenoviral vector and provided evidence that this vector possessed high anti-tumor activity and uveal melanoma specificity. ..
  69. Li Y, Zhang D, Wang X, Yao X, Ye C, Zhang S, et al. Hypoxia-inducible miR-182 enhances HIF1α signaling via targeting PHD2 and FIH1 in prostate cancer. Sci Rep. 2015;5:12495 pubmed publisher
    ..Together, our results suggest that the interplay between miR-182 and HIF1α could result in a sustained activation of HIF1α pathway, which might facilitate tumor cell adaption to hypoxic stress during prostate tumor progression. ..
  70. Abdelrahman M, Fawzy I, Bassiouni A, Gomaa A, Esmat G, Waked I, et al. Enhancing NK cell cytotoxicity by miR-182 in hepatocellular carcinoma. Hum Immunol. 2016;77:667-673 pubmed publisher
    ..Our findings suggest that miR-182 may augment NK-cell cytotoxicity against liver cancer via modulating NKG2D and NKG2A expressions. ..
  71. Sun J, Ji J, Huo G, Song Q, Zhang X. miR-182 induces cervical cancer cell apoptosis through inhibiting the expression of DNMT3a. Int J Clin Exp Pathol. 2015;8:4755-63 pubmed
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    ..These results demonstrate that a single miRNA can regulate metastasis of primary tumors in vivo by coordinated regulation of multiple genes. ..
  73. Yang M, Yu J, Jiang D, Li W, Wang S, Ding Y. microRNA-182 targets special AT-rich sequence-binding protein 2 to promote colorectal cancer proliferation and metastasis. J Transl Med. 2014;12:109 pubmed publisher
    ..Our results illustrated that the up-regulation of miR-182 played a pivotal role in CRC tumorigenesis and metastasis, which suggesting a potential implication of miR-182 in the molecular therapy for CRC. ..
  74. Stenvold H, Donnem T, Andersen S, Al Saad S, Busund L, Bremnes R. Stage and tissue-specific prognostic impact of miR-182 in NSCLC. BMC Cancer. 2014;14:138 pubmed publisher
    ..In patients with SCC and in stage II patients, high tumor cell miR-182 expression is an independent positive prognostic factor. ..