MIR17

Summary

Gene Symbol: MIR17
Description: microRNA 17
Alias: MIR17-5p, MIR91, MIRN17, MIRN91, hsa-mir-17, miR-17, miR17-3p, miRNA17, miRNA91
Species: human
Products:     MIR17

Top Publications

  1. He L, Thomson J, Hemann M, Hernando Monge E, Mu D, Goodson S, et al. A microRNA polycistron as a potential human oncogene. Nature. 2005;435:828-33 pubmed
    ..Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene. ..
  2. O Donnell K, Wentzel E, Zeller K, Dang C, Mendell J. c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 2005;435:839-43 pubmed
  3. Xiao C, Srinivasan L, Calado D, Patterson H, Zhang B, Wang J, et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol. 2008;9:405-14 pubmed publisher
    ..This mechanism probably contributed to the lymphoproliferative disease and autoimmunity of miR-17-92-transgenic mice and contributes to lymphoma development in patients with amplifications of the miR-17-92 coding region. ..
  4. Li H, Yang B. Stress response of glioblastoma cells mediated by miR-17-5p targeting PTEN and the passenger strand miR-17-3p targeting MDM2. Oncotarget. 2012;3:1653-68 pubmed
    ..Finally, we demonstrated that miR-17 could repress MDM2 levels, resulting in decreased cell proliferation and drug-resistance. Our results added a new layer of functional mechanism for the well-studied miRNA miR-17. ..
  5. Liu W, Liu Y, Guo T, Hu C, Luo H, Zhang L, et al. TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments. Cell Death Dis. 2013;4:e539 pubmed publisher
    ..This understanding of microRNAs regulating signaling pathways in different microenvironments may pave the way for fine-tuning the process of osteogenesis in bone-related disorders. ..
  6. Yu Z, Willmarth N, Zhou J, Katiyar S, Wang M, Liu Y, et al. microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci U S A. 2010;107:8231-6 pubmed publisher
    ..These findings not only reveal an antiinvasive function of miR-17/20 in breast cancer, but also identify a heterotypic secreted signal that mediates the microRNA regulation of tumor metastasis. ..
  7. Taguchi A, Yanagisawa K, Tanaka M, Cao K, Matsuyama Y, Goto H, et al. Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster. Cancer Res. 2008;68:5540-5 pubmed publisher
  8. Cloonan N, Brown M, Steptoe A, Wani S, Chan W, Forrest A, et al. The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition. Genome Biol. 2008;9:R127 pubmed publisher
    ..Additionally, we have demonstrated the utility of a systems biology approach as a unique and rapid approach to uncover microRNA function. ..
  9. He M, Wang Q, Yin Q, Tang J, Lu Y, Zhou C, et al. HIF-1? downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation. Cell Death Differ. 2013;20:408-18 pubmed publisher
    ..Taken together, our results suggest that HIF-1? regulates the miRNA network to interfere with AML cell differentiation, representing a novel molecular mechanism for HIF-1-mediated anti-leukemic action. ..
  10. Shan S, Fang L, Shatseva T, Rutnam Z, Yang X, Du W, et al. Mature miR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7 and vimentin in different signal pathways. J Cell Sci. 2013;126:1517-30 pubmed publisher
    ..We anticipate that our assay will serve as a helpful model for studying miRNA regulation. ..

Detail Information

Publications82

  1. He L, Thomson J, Hemann M, Hernando Monge E, Mu D, Goodson S, et al. A microRNA polycistron as a potential human oncogene. Nature. 2005;435:828-33 pubmed
    ..Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene. ..
  2. O Donnell K, Wentzel E, Zeller K, Dang C, Mendell J. c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 2005;435:839-43 pubmed
  3. Xiao C, Srinivasan L, Calado D, Patterson H, Zhang B, Wang J, et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol. 2008;9:405-14 pubmed publisher
    ..This mechanism probably contributed to the lymphoproliferative disease and autoimmunity of miR-17-92-transgenic mice and contributes to lymphoma development in patients with amplifications of the miR-17-92 coding region. ..
  4. Li H, Yang B. Stress response of glioblastoma cells mediated by miR-17-5p targeting PTEN and the passenger strand miR-17-3p targeting MDM2. Oncotarget. 2012;3:1653-68 pubmed
    ..Finally, we demonstrated that miR-17 could repress MDM2 levels, resulting in decreased cell proliferation and drug-resistance. Our results added a new layer of functional mechanism for the well-studied miRNA miR-17. ..
  5. Liu W, Liu Y, Guo T, Hu C, Luo H, Zhang L, et al. TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments. Cell Death Dis. 2013;4:e539 pubmed publisher
    ..This understanding of microRNAs regulating signaling pathways in different microenvironments may pave the way for fine-tuning the process of osteogenesis in bone-related disorders. ..
  6. Yu Z, Willmarth N, Zhou J, Katiyar S, Wang M, Liu Y, et al. microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci U S A. 2010;107:8231-6 pubmed publisher
    ..These findings not only reveal an antiinvasive function of miR-17/20 in breast cancer, but also identify a heterotypic secreted signal that mediates the microRNA regulation of tumor metastasis. ..
  7. Taguchi A, Yanagisawa K, Tanaka M, Cao K, Matsuyama Y, Goto H, et al. Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster. Cancer Res. 2008;68:5540-5 pubmed publisher
  8. Cloonan N, Brown M, Steptoe A, Wani S, Chan W, Forrest A, et al. The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition. Genome Biol. 2008;9:R127 pubmed publisher
    ..Additionally, we have demonstrated the utility of a systems biology approach as a unique and rapid approach to uncover microRNA function. ..
  9. He M, Wang Q, Yin Q, Tang J, Lu Y, Zhou C, et al. HIF-1? downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation. Cell Death Differ. 2013;20:408-18 pubmed publisher
    ..Taken together, our results suggest that HIF-1? regulates the miRNA network to interfere with AML cell differentiation, representing a novel molecular mechanism for HIF-1-mediated anti-leukemic action. ..
  10. Shan S, Fang L, Shatseva T, Rutnam Z, Yang X, Du W, et al. Mature miR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7 and vimentin in different signal pathways. J Cell Sci. 2013;126:1517-30 pubmed publisher
    ..We anticipate that our assay will serve as a helpful model for studying miRNA regulation. ..
  11. Inomata M, Tagawa H, Guo Y, Kameoka Y, Takahashi N, Sawada K. MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes. Blood. 2009;113:396-402 pubmed publisher
    ..Thus, CDKN1A/p21 appears to be an essential target of miR-17-92 during B-cell lymphomagenesis, which suggests the miR-17-92 polycistron has distinct targets in different B-cell lymphoma subtypes. ..
  12. Dews M, Fox J, Hultine S, Sundaram P, Wang W, Liu Y, et al. The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors. Cancer Res. 2010;70:8233-46 pubmed publisher
    ..Together, our results define a pathway in which c-Myc activation of miR-17?92 attenuates the TGF? signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth. ..
  13. Chen Q, Si Q, Xiao S, Xie Q, Lin J, Wang C, et al. Prognostic significance of serum miR-17-5p in lung cancer. Med Oncol. 2013;30:353 pubmed publisher
    ..039-3.005, P = 0.035]. A lower expression level of serum miR-17-5p helps extend the survival of patients with lung cancer. Thus, miR-17-5p may be potential biomarker for prediction the prognosis in patients with lung cancer. ..
  14. Dakhlallah D, Batte K, Wang Y, Cantemir Stone C, Yan P, Nuovo G, et al. Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med. 2013;187:397-405 pubmed publisher
    ..This study provides insight into the pathobiology of IPF and identifies a novel epigenetic feedback loop between miR-17~92 and DNMT-1 in lung fibrosis. ..
  15. Yu Z, Wang C, Wang M, Li Z, Casimiro M, Liu M, et al. A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol. 2008;182:509-17 pubmed publisher
    ..In turn, miR-17/20 limits the proliferative function of cyclin D1, thus linking expression of a specific miRNA cluster to the regulation of oncogenesis. ..
  16. Venturini L, Battmer K, Castoldi M, Schultheis B, Hochhaus A, Muckenthaler M, et al. Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells. Blood. 2007;109:4399-405 pubmed
    ..Altered miRNA expression may contribute to the pathophysiology of the disease and may provide potential targets for therapeutic intervention. ..
  17. Liu Y, Liu W, Hu C, Xue Z, Wang G, Ding B, et al. MiR-17 modulates osteogenic differentiation through a coherent feed-forward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis. Stem Cells. 2011;29:1804-16 pubmed publisher
  18. Shan S, Lee D, Deng Z, Shatseva T, Jeyapalan Z, Du W, et al. MicroRNA MiR-17 retards tissue growth and represses fibronectin expression. Nat Cell Biol. 2009;11:1031-8 pubmed publisher
    ..We anticipate that this could serve as a model for studying gene regulation by miRNAs in the development of gene therapy. ..
  19. Nemlich Y, Greenberg E, Ortenberg R, Besser M, Barshack I, Jacob Hirsch J, et al. MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth. J Clin Invest. 2013;123:2703-18 pubmed
    ..We further demonstrated that the genes encoding miR-17 and miR-432 are frequently amplified in melanoma and that aberrant hypomethylation of the imprinted DLK1-DIO3 region in chromosome 14 can also drive miR-432 overexpression. ..
  20. Zhou H, Guo J, Lou Y, Zhang X, Zhong F, Jiang Z, et al. Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker. J Mol Med (Berl). 2010;88:709-17 pubmed publisher
    ..684 (p = 0.0066), 0.743 (p = 0.0001), and 0.741 (p = 0.0002), respectively. Our results indicate that the detection of miRNA in peripheral blood may be a novel tool for monitoring circulating tumor cells in patients with gastric cancers. ..
  21. Luo H, Zou J, Dong Z, Zeng Q, Wu D, Liu L. Up-regulated miR-17 promotes cell proliferation, tumour growth and cell cycle progression by targeting the RND3 tumour suppressor gene in colorectal carcinoma. Biochem J. 2012;442:311-21 pubmed publisher
    ..In conclusion, the present study suggests that miR-17 plays an important role in CRC carcinogenesis by targeting RND3 and may be a therapeutic agent for CRC. ..
  22. Wei Q, Li Y, Liu M, Li X, Tang H. MiR-17-5p targets TP53INP1 and regulates cell proliferation and apoptosis of cervical cancer cells. IUBMB Life. 2012;64:697-704 pubmed publisher
    ..The same correlations between miR-17-5p and TP53INP1 were observed in cervical cancer tissues. Together, these results indicated that miR-17-5p functions as a tumor suppressor in cervical cancer cells by targeting TP53INP1. ..
  23. Yu J, Ohuchida K, Mizumoto K, Fujita H, Nakata K, Tanaka M. MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion. Cancer Biol Ther. 2010;10:748-57 pubmed publisher
    ..0001 for both). The present findings suggest that miR-17-5p plays important roles in pancreatic carcinogenesis and cancer progression, and is associated with a poor prognosis in pancreatic cancer. ..
  24. Serva A, Knapp B, Tsai Y, Claas C, Lisauskas T, Matula P, et al. miR-17-5p regulates endocytic trafficking through targeting TBC1D2/Armus. PLoS ONE. 2012;7:e52555 pubmed publisher
    ..Our study reveals regulation of endocytic trafficking as a novel function of miR-17, which might act cooperatively with other functions of miR-17 and related miRNAs in health and disease. ..
  25. Hackl M, Brunner S, Fortschegger K, Schreiner C, Micutkova L, Muck C, et al. miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. Aging Cell. 2010;9:291-6 pubmed publisher
    ..Decrease in these miRNAs correlated with increased transcript levels of some established target genes, especially the cdk inhibitor p21/CDKN1A. These results establish miRNAs as novel markers of cell aging in humans. ..
  26. Mestdagh P, Boström A, Impens F, Fredlund E, Van Peer G, De Antonellis P, et al. The miR-17-92 microRNA cluster regulates multiple components of the TGF-? pathway in neuroblastoma. Mol Cell. 2010;40:762-73 pubmed publisher
    ..By functioning both upstream and downstream of pSMAD2, miR-17-92 activation triggers downregulation of multiple key effectors along the TGF-? signaling cascade as well as direct inhibition of TGF-?-responsive genes. ..
  27. Yang F, Yin Y, Wang F, Wang Y, Zhang L, Tang Y, et al. miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway. Hepatology. 2010;51:1614-23 pubmed publisher
    ..Our data highlight an important role of miR-17-5p in the proliferation and migration of HCC cells and support the potential application of miR-17-5p in HCC therapy. ..
  28. Chang C, Yang Y, Li Y, Chen S, Lin B, Wu T, et al. MicroRNA-17/20a functions to inhibit cell migration and can be used a prognostic marker in oral squamous cell carcinoma. Oral Oncol. 2013;49:923-931 pubmed publisher
    ..To access whether the possible miRNA prognostic markers and underlying mechanisms, we developed a highly migratory TW2.6 MS-10 cells from TW2.6 cells to investigate the issue...
  29. Zeng X, Xiang J, Wu M, Xiong W, Tang H, Deng M, et al. Circulating miR-17, miR-20a, miR-29c, and miR-223 combined as non-invasive biomarkers in nasopharyngeal carcinoma. PLoS ONE. 2012;7:e46367 pubmed publisher
    ..We demonstrate that the serum miRNA-based biomarker model become a novel tool for NPC detection. The circulating 4-miRNA-based method may provide a novel strategy for NPC diagnosis. ..
  30. Hossain A, Kuo M, Saunders G. Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol. 2006;26:8191-201 pubmed
    ..Mir-17-5p also completely abrogated the insulin-like growth factor 1-mediated, anchorage-independent growth of breast cancer cells. Our results reveal that Mir-17-5p has a role as a tumor suppressor in breast cancer cells. ..
  31. Wang M, Gu H, Qian H, Zhu W, Zhao C, Zhang X, et al. miR-17-5p/20a are important markers for gastric cancer and murine double minute 2 participates in their functional regulation. Eur J Cancer. 2013;49:2010-21 pubmed publisher
    ..They may be promising therapeutic markers for gastric cancer. MDM2 contributes to miR-17-5p/20a function and inhibition of p21 in gastric cancer, and may be a novel mechanism underlying the oncogenic roles of miR-17-5p/20a. ..
  32. Lindberg R, Hoffmann F, Mehling M, Kuhle J, Kappos L. Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients. Eur J Immunol. 2010;40:888-98 pubmed publisher
    ..Our findings support the role of miRNA-dependent regulatory mechanisms in the immunopathogenesis of MS. ..
  33. Mraz M, Pospisilova S, Malinova K, Slapak I, Mayer J. MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtypes. Leuk Lymphoma. 2009;50:506-9 pubmed publisher
    ..Consequently, these three miRNAs could potentially play important roles in the pathogenesis of aggressive CLL. ..
  34. Pickering M, Stadler B, Kowalik T. miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression. Oncogene. 2009;28:140-5 pubmed publisher
    ..These data provide a mechanistic view of miRNA-based regulation of E2F1 in the context of the emerging model that miRNAs coordinate the timing of cell cycle progression. ..
  35. Conkrite K, Sundby M, Mukai S, Thomson J, Mu D, Hammond S, et al. miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. Genes Dev. 2011;25:1734-45 pubmed publisher
    ..These results demonstrate that the oncogenic determinants of miR-17~92 are context-specific and provide new insights into miR-17~92 function as an RB-collaborating gene in cancer...
  36. Fang L, Li H, Wang L, Hu J, Jin T, Wang J, et al. MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression. Oncotarget. 2014;5:2974-87 pubmed
    ..MiR-17-5p is a predictive factor for chemotherapy response and a prognostic factor for overall survival in CRC, which is due to its regulation of PTEN expression. ..
  37. Pan Y, Guo Y, Luo Y, Li H, Xu Y. MicroRNA expression profiling of Chinese follicular lymphoma by microarray: A preliminary study. Int Immunopharmacol. 2016;39:41-47 pubmed publisher
    ..Furthermore, the expression of miR-19a-3p and miR-17-5p were found to be significantly upregulated in FL3a. Further study needs to be urgently performed to reveal its potential role in the pathogenesis of FL in the near future. ..
  38. Jiang Z, Yin J, Fu W, Mo Y, Pan Y, Dai L, et al. MiRNA 17 family regulates cisplatin-resistant and metastasis by targeting TGFbetaR2 in NSCLC. PLoS ONE. 2014;9:e94639 pubmed publisher
    ..Consequently, our study suggests that miRNA 17 family (including miR-17, 20a, 20b) can act as TGF?R2 suppressor for reversing cisplatin-resistant and suppressing metastasis in NSCLC. ..
  39. Chacon Cortes D, Smith R, Lea R, Youl P, Griffiths L. Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer. Tumour Biol. 2015;36:5369-76 pubmed publisher
    ..Finally, functional studies of these SNPs could provide a deeper understanding of the role that MIR17HG plays in the pathophysiology of breast cancer. ..
  40. Karami F, Mohammadi Yeganeh S, Abedi N, Koochaki A, Kia V, Paryan M. Bioinformatics Prediction and In Vitro Analysis Revealed That miR-17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells. Chem Biol Drug Des. 2016;87:317-20 pubmed publisher
    ..We found miR-17 as an attractive molecule that after intensive research can probably be used as a biomarker in TNBC. ..
  41. Wu Z, Li W, Lin S, Wang C, Cai L, Lu J, et al. MicroRNA expression profile of bromocriptine-resistant prolactinomas. Mol Cell Endocrinol. 2014;395:10-8 pubmed publisher
    ..Mir-93 directly affected p21 expression in MMQ cells by targeting the 3'-UTR. Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. ..
  42. Jiang H, Wang P, Li X, Wang Q, Deng Z, Zhuang X, et al. Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2. Cancer Immunol Res. 2014;2:789-99 pubmed publisher
    ..In this proof-of-concept study, the restoration of high-level expression of the miR17-92 cluster of miRNAs reveals its function as a tumor suppressor in murine solid cancer cells...
  43. Poitz D, Augstein A, Gradehand C, Ende G, Schmeisser A, Strasser R. Regulation of the Hif-system by micro-RNA 17 and 20a - role during monocyte-to-macrophage differentiation. Mol Immunol. 2013;56:442-51 pubmed publisher
    ..This activation is in part mediated by a miRNA-dependent mechanism, which seems to be crucial for the adaption of macrophages to hypoxia. ..
  44. Dhar S, Kumar A, Rimando A, Zhang X, Levenson A. Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer. Oncotarget. 2015;6:27214-26 pubmed publisher
  45. Hua Y, Larsen N, Kalyana Sundaram S, Kjems J, Chinnaiyan A, Peter M. miRConnect 2.0: identification of oncogenic, antagonistic miRNA families in three human cancers. BMC Genomics. 2013;14:179 pubmed publisher
    ..miRConnect 2.0 is useful for identifying activities of miRNAs that are relevant to primary cancers. The new correlation data on miRNAs and mRNAs deregulated in three primary cancers are available at miRConnect.org. ..
  46. Robertus J, Harms G, Blokzijl T, Booman M, de Jong D, Van Imhoff G, et al. Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma. Mod Pathol. 2009;22:547-55 pubmed publisher
    ..05). We conclude that the location of diffuse large B-cell lymphoma is an important factor in determining the differential expression of miRNAs. ..
  47. Thompson M, Edmonds M, Liang S, McClintock Treep S, Wang X, Li S, et al. miR-31 and miR-17-5p levels change during transformation of follicular lymphoma. Hum Pathol. 2016;50:118-26 pubmed publisher
    ..Our results indicate that changes in miR-31 and miR-17-5p reflect the transformation of follicular lymphoma to an aggressive large B-cell lymphoma and may, along with their targets, be viable markers for this process. ..
  48. Qu Y, Zhang H, Duan J, Liu R, Deng T, Bai M, et al. MiR-17-5p regulates cell proliferation and migration by targeting transforming growth factor-? receptor 2 in gastric cancer. Oncotarget. 2016;7:33286-96 pubmed publisher
    ..The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer. ..
  49. Geng X, Qiu S, Yang L, Liu Z, Yang G, Liu J, et al. Allergen-specific immune response suppresses interleukin 10 expression in B cells via increasing micro-RNA-17-92 cluster. Cell Biochem Funct. 2016;34:449-54 pubmed publisher
    ..In conclusion, miR-19a mediates the allergen-specific immune response-decreased IL-10 expression in B cells. ..
  50. Mraz M, Malinova K, Kotaskova J, Pavlova S, Tichy B, Malcikova J, et al. miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities. Leukemia. 2009;23:1159-63 pubmed publisher
  51. Chen J, Huang Y, Mazzoni E, Tan G, Zavadil J, Wichterle H. Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop. Neuron. 2011;69:721-35 pubmed publisher
  52. Wu Q, Luo G, Yang Z, Zhu F, An Y, Shi Y, et al. miR-17-5p promotes proliferation by targeting SOCS6 in gastric cancer cells. FEBS Lett. 2014;588:2055-62 pubmed publisher
    ..In short, miR-17-5p might function as a pro-proliferative factor by repressing SOCS6 in gastric cancer. ..
  53. Xu Z, Zhao L, Zhu L, He M, Zheng L, Wu Y. MicroRNA-17, 20a regulates the proangiogenic function of tumor-associated macrophages via targeting hypoxia-inducible factor 2?. PLoS ONE. 2013;8:e77890 pubmed publisher
  54. Yan H, Liu W, Sun W, Wu J, Ji M, Wang Q, et al. miR-17-5p inhibitor enhances chemosensitivity to gemcitabine via upregulating Bim expression in pancreatic cancer cells. Dig Dis Sci. 2012;57:3160-7 pubmed publisher
    ..These results prove that miR-17-5p negatively regulates Bim at the posttranscriptional level. We suggest that miR-17-5p inhibitor gene therapy would be a novel approach to chemosensitization for human pancreatic cancer. ..
  55. Greenberg E, Hajdu S, Nemlich Y, Cohen R, Itzhaki O, Jacob Hirsch J, et al. Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. Open Biol. 2014;4:140030 pubmed publisher
    ..This suggests that the two non-seed nucleotides dictate target sequence recognition and overall functional relevance. These miRNAs are clearly not redundant in melanoma cell biology. ..
  56. Faltejskova P, Bocanek O, Sachlova M, Svoboda M, Kiss I, Vyzula R, et al. Circulating miR-17-3p, miR-29a, miR-92a and miR-135b in serum: Evidence against their usage as biomarkers in colorectal cancer. Cancer Biomark. 2012;12:199-204 pubmed publisher
  57. Ben David E, Bester A, Shifman S, Kerem B. Transcriptional dynamics in colorectal carcinogenesis: new insights into the role of c-Myc and miR17 in benign to cancer transformation. Cancer Res. 2014;74:5532-40 pubmed publisher
    ..The analysis of miRNAs targets pointed toward the involvement of miR17 in the regulation of colon cell differentiation...
  58. Wu S, Lin K, Chiou J, Jeng S, Cheng W, Chang C, et al. MicroRNA-17-5p post-transcriptionally regulates p21 expression in irradiated betel quid chewing-related oral squamous cell carcinoma cells. Strahlenther Onkol. 2013;189:675-83 pubmed publisher
    ..miR-17-5p is induced in irradiated OC3 cells and it downregulates p21 protein expression, contributing to the radioresistance of OC3 cells. ..
  59. Wong J, Duncan C, Beveridge N, Webster M, Cairns M, Weickert C. Expression of NPAS3 in the human cortex and evidence of its posttranscriptional regulation by miR-17 during development, with implications for schizophrenia. Schizophr Bull. 2013;39:396-406 pubmed publisher
    ..Further studies into how changes in NPAS3 or its miRNA regulator may influence the development of schizophrenia are warranted. ..
  60. Roisman A, Huamán Garaicoa F, Metrebian F, Narbaitz M, Kohan D, García Rivello H, et al. SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma. Genes Chromosomes Cancer. 2016;55:531-40 pubmed publisher
    ..In this study we screened the transcriptional profiles of 70 MCL patients for SOXC cluster and miR17, miR18a, miR19b and miR92a, from the miR-17-92 cluster...
  61. Park D, Lee S, Park J, Cho S, Kim H. Overexpression of miR-17 in gastric cancer is correlated with proliferation-associated oncogene amplification. Pathol Int. 2014;64:309-14 pubmed publisher
    ..Therefore, miR-17-targeting approach may benefit patients with gastric cancers harboring proliferation-associated oncogene amplification...
  62. Sarhan R, Aboelenein H, Sourour S, Fawzy I, Salah S, Abdelaziz A. Targeting E2F1 and c-Myc expression by microRNA-17-5p represses interferon-stimulated gene MxA in peripheral blood mononuclear cells of pediatric systemic lupus erythematosus patients. Discov Med. 2015;19:419-25 pubmed
    ..This may advocate the manipulation/use of the E2F1/c-Myc/miR-17-5p trinity to effectively control the aberrantly high levels of type I IFN activity in lupus patients. ..
  63. Nakamura S, Horie M, Daidoji T, Honda T, Yasugi M, Kuno A, et al. Influenza A Virus-Induced Expression of a GalNAc Transferase, GALNT3, via MicroRNAs Is Required for Enhanced Viral Replication. J Virol. 2016;90:1788-801 pubmed publisher
    ..Our results have broad implications for understanding IAV replication and suggest a strategy for the development of novel anti-influenza approaches. ..
  64. Wei B, Wei W, Zhao B, Guo X, Liu S. Long non-coding RNA HOTAIR inhibits miR-17-5p to regulate osteogenic differentiation and proliferation in non-traumatic osteonecrosis of femoral head. PLoS ONE. 2017;12:e0169097 pubmed publisher
    ..HOTAIR played a role in regulating osteogenic differentiation and proliferation through modulating miR-17-5p and its target gene SMAD7 in non-traumatic ONFH. ..
  65. Jin Y, Jin Y, Chen B, Tipple T, Nelin L. Arginase II is a target of miR-17-5p and regulates miR-17-5p expression in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2014;307:L197-204 pubmed publisher
    ..We also found that l-arginine, the substrate for arginase II, and l-ornithine, the amino acid product of arginase II, were not involved in the regulation of miR-17-5p expression. ..
  66. Aguda B, Kim Y, Piper Hunter M, Friedman A, Marsh C. MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc. Proc Natl Acad Sci U S A. 2008;105:19678-83 pubmed publisher
    ..Using the concept and model prediction of a "cancer zone," the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc. ..
  67. Zhang X, Kong Y, Xu X, Xing H, Zhang Y, Han F, et al. F-box protein FBXO31 is down-regulated in gastric cancer and negatively regulated by miR-17 and miR-20a. Oncotarget. 2014;5:6178-90 pubmed
    ..Therefore, effective therapy targeting the miR-20a (miR-17)-FBXO31-CyclinD1 pathway may help control GC progression. ..
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    ..They regulate EPHB4 and ephrin-B2 expression in trophoblast and endothelial cells via the same "seed" sequence, suggesting their roles in early placental development. ..
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    ..We suggest that these main members of the microRNA-17-92 cluster might be involved in placental invasion and its dysregulation might also be related to other conditions characterized by defective placentation. ..
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    ..These results suggest that miR-17-5p increases or decreases apoptosis-related proteins in irradiated OC3 cells; its effect on p53 protein expression contributes to the modulation of the radiosensitivity of the OC3 cells. ..
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    ..The beneficial effects may be related to the up-regulation of p21. Thus, inhibition of miR-17 may represent a novel therapeutic concept to ameliorate disease state in PH. ..
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    ..002 and p = .042, respectively). miR-17-5p is highly elevated in HCC, especially in HCC with metastasis. miR-17-5p can serve as a novel prognostic marker for HCC. ..
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    ..Our results indicate that miR-17 might serve as an important intracellular target of glucose to mediate the mitogenic effect that glucose exerts in pancreatic β-cells. ..
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    ..Our data demonstrated that CB CD34(+) cell expansion can be partly promoted by osteoblastic miR-17, and in particular, ectopic miR-17 can cause a specific expansion of the erythroid lineage through augmenting HIF-1? in osteoblasts. ..
  77. Zhuo D, Niu X, Chen Y, Xin D, Guo Y, Mao Z. Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblasts. J Biol Chem. 2010;285:31491-501 pubmed publisher
    ..These results indicated that VDUP1 expression was regulated by FOXO3A at the transcriptional level and by miR-17-5p at the post-transcriptional levels during the senescence process. ..
  78. Gong A, Eischeid A, Xiao J, Zhao J, Chen D, Wang Z, et al. miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells. BMC Cancer. 2012;12:492 pubmed publisher
    ..PCAF is upregulated in cultured PCa cells, and upregulation of PCAF is associated with the downregulation of miR-17-5p. Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells. ..
  79. Knudsen K, Nielsen B, Lindebjerg J, Hansen T, Holst R, Sørensen F. microRNA-17 Is the Most Up-Regulated Member of the miR-17-92 Cluster during Early Colon Cancer Evolution. PLoS ONE. 2015;10:e0140503 pubmed publisher
    ..It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer. ..
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