MIR155

Summary

Gene Symbol: MIR155
Description: microRNA 155
Alias: MIRN155, miRNA155
Species: human
Products:     MIR155

Top Publications

  1. Tam W, Dahlberg J. miR-155/BIC as an oncogenic microRNA. Genes Chromosomes Cancer. 2006;45:211-2 pubmed
  2. Greither T, Grochola L, Udelnow A, Lautenschlager C, Wurl P, Taubert H. Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival. Int J Cancer. 2010;126:73-80 pubmed publisher
    ..Furthermore, the putative target genes for these microRNAs suggest a complex signaling network that can affect PDAC tumorigenesis and tumor progression...
  3. Yin Q, Wang X, McBride J, Fewell C, Flemington E. B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element. J Biol Chem. 2008;283:2654-62 pubmed
    ..These results identify key determinants of BCR-mediated signaling that lead to the induction of BIC/miR-155. ..
  4. Kim J, Kim W, Park C. Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt activation and up-regulation of Mcl-1. Leuk Lymphoma. 2012;53:1586-91 pubmed publisher
    ..Thus, we propose Akt and Mcl-1 and miR-155 as molecular targets for therapeutic intervention in the treatment of EBV-associated B-cell lymphoma with rituximab...
  5. Swaminathan G, Rossi F, Sierra L, Gupta A, Navas Martin S, MARTIN GARCIA J. A role for microRNA-155 modulation in the anti-HIV-1 effects of Toll-like receptor 3 stimulation in macrophages. PLoS Pathog. 2012;8:e1002937 pubmed publisher
    ..Our findings provide evidence that miR-155 exerts an anti-HIV-1 effect by targeting several HIV-1 dependency factors involved in post-entry, pre-integration events, leading to severely diminished HIV-1 infection. ..
  6. Jiang S, Zhang H, Lu M, He X, Li Y, Gu H, et al. MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Cancer Res. 2010;70:3119-27 pubmed publisher
    ..Taken together, our study reveals that miR-155 is an oncomiR in breast cancer and that miR-155 may be a potential target in breast cancer therapy. ..
  7. Skårn M, Namløs H, Noordhuis P, Wang M, Meza Zepeda L, Myklebost O. Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222. Stem Cells Dev. 2012;21:873-83 pubmed publisher
  8. Dunand Sauthier I, Santiago Raber M, Capponi L, Vejnar C, Schaad O, Irla M, et al. Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function. Blood. 2011;117:4490-500 pubmed publisher
    ..There is growing evidence that microRNA-155 (miR155) modulates gene expression in various cell types of the immune system and is a prominent player in the regulation ..
  9. Ceppi M, Pereira P, Dunand Sauthier I, Barras E, Reith W, Santos M, et al. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc Natl Acad Sci U S A. 2009;106:2735-40 pubmed publisher
    ..Our observations suggest, therefore, that in mature human DCs, miR-155 is part of a negative feedback loop, which down-modulates inflammatory cytokine production in response to microbial stimuli. ..
  10. Pauley K, Satoh M, Chan A, Bubb M, Reeves W, Chan E. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther. 2008;10:R101 pubmed publisher

Detail Information

Publications73

  1. Tam W, Dahlberg J. miR-155/BIC as an oncogenic microRNA. Genes Chromosomes Cancer. 2006;45:211-2 pubmed
  2. Greither T, Grochola L, Udelnow A, Lautenschlager C, Wurl P, Taubert H. Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival. Int J Cancer. 2010;126:73-80 pubmed publisher
    ..Furthermore, the putative target genes for these microRNAs suggest a complex signaling network that can affect PDAC tumorigenesis and tumor progression...
  3. Yin Q, Wang X, McBride J, Fewell C, Flemington E. B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element. J Biol Chem. 2008;283:2654-62 pubmed
    ..These results identify key determinants of BCR-mediated signaling that lead to the induction of BIC/miR-155. ..
  4. Kim J, Kim W, Park C. Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt activation and up-regulation of Mcl-1. Leuk Lymphoma. 2012;53:1586-91 pubmed publisher
    ..Thus, we propose Akt and Mcl-1 and miR-155 as molecular targets for therapeutic intervention in the treatment of EBV-associated B-cell lymphoma with rituximab...
  5. Swaminathan G, Rossi F, Sierra L, Gupta A, Navas Martin S, MARTIN GARCIA J. A role for microRNA-155 modulation in the anti-HIV-1 effects of Toll-like receptor 3 stimulation in macrophages. PLoS Pathog. 2012;8:e1002937 pubmed publisher
    ..Our findings provide evidence that miR-155 exerts an anti-HIV-1 effect by targeting several HIV-1 dependency factors involved in post-entry, pre-integration events, leading to severely diminished HIV-1 infection. ..
  6. Jiang S, Zhang H, Lu M, He X, Li Y, Gu H, et al. MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Cancer Res. 2010;70:3119-27 pubmed publisher
    ..Taken together, our study reveals that miR-155 is an oncomiR in breast cancer and that miR-155 may be a potential target in breast cancer therapy. ..
  7. Skårn M, Namløs H, Noordhuis P, Wang M, Meza Zepeda L, Myklebost O. Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222. Stem Cells Dev. 2012;21:873-83 pubmed publisher
  8. Dunand Sauthier I, Santiago Raber M, Capponi L, Vejnar C, Schaad O, Irla M, et al. Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function. Blood. 2011;117:4490-500 pubmed publisher
    ..There is growing evidence that microRNA-155 (miR155) modulates gene expression in various cell types of the immune system and is a prominent player in the regulation ..
  9. Ceppi M, Pereira P, Dunand Sauthier I, Barras E, Reith W, Santos M, et al. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc Natl Acad Sci U S A. 2009;106:2735-40 pubmed publisher
    ..Our observations suggest, therefore, that in mature human DCs, miR-155 is part of a negative feedback loop, which down-modulates inflammatory cytokine production in response to microbial stimuli. ..
  10. Pauley K, Satoh M, Chan A, Bubb M, Reeves W, Chan E. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther. 2008;10:R101 pubmed publisher
  11. Zhang P, Bill K, Liu J, Young E, Peng T, Bolshakov S, et al. MiR-155 is a liposarcoma oncogene that targets casein kinase-1? and enhances ?-catenin signaling. Cancer Res. 2012;72:1751-62 pubmed publisher
    ..In summary, our results point to important functions for miR-155 and ?-catenin signaling in progression of liposarcoma, revealing mechanistic vulnerabilities that might be exploited for both prognostic and therapeutic purposes...
  12. Martinez Nunez R, Louafi F, Friedmann P, Sanchez Elsner T. MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN). J Biol Chem. 2009;284:16334-42 pubmed publisher
    ..Thus, our results suggest a mechanism by which miR-155 regulates proteins involved in the cellular immune response against pathogens that could have clinical implications in the way pathogens enter the human organism. ..
  13. Rokah O, Granot G, Ovcharenko A, Modai S, Pasmanik Chor M, Toren A, et al. Downregulation of miR-31, miR-155, and miR-564 in chronic myeloid leukemia cells. PLoS ONE. 2012;7:e35501 pubmed publisher
    ..These deregulated miRNAs highlight new candidate gene targets allowing for a better understanding of the molecular mechanism underlying the development of CML, and propose possible new avenues for therapeutic treatment. ..
  14. Martinez Nunez R, Louafi F, Sanchez Elsner T. The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1). J Biol Chem. 2011;286:1786-94 pubmed publisher
    ..Our work shows a central role for miR-155 in determining the M2 phenotype in human macrophages. ..
  15. Elton T, Selemon H, Elton S, Parinandi N. Regulation of the MIR155 host gene in physiological and pathological processes. Gene. 2013;532:1-12 pubmed publisher
    ..miR-155-5p and miR-155-3p are processed from the B-cell Integration Cluster (BIC) gene (now designated, MIR155 host gene or MIR155HG)...
  16. Min M, Peng L, Yang Y, Guo M, Wang W, Sun G. MicroRNA-155 is involved in the pathogenesis of ulcerative colitis by targeting FOXO3a. Inflamm Bowel Dis. 2014;20:652-9 pubmed publisher
    ..miR-155 appears to play a role in the intestinal inflammation of patients with active UC by downregulating the expression of FOXO3a. This process may activate the nuclear factor kappa B signaling pathway. ..
  17. Kohlhaas S, Garden O, Scudamore C, Turner M, Okkenhaug K, Vigorito E. Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol. 2009;182:2578-82 pubmed publisher
    ..However, we found no evidence for defective suppressor activity of miR-155-deficient Tregs, either in vitro or in vivo. Our results indicate that miR-155 contributes to Treg development, but that additional miRNAs control Treg function. ..
  18. Levati L, Pagani E, Romani S, Castiglia D, Piccinni E, Covaciu C, et al. MicroRNA-155 targets the SKI gene in human melanoma cell lines. Pigment Cell Melanoma Res. 2011;24:538-50 pubmed publisher
    ..Our data demonstrate for the first time that SKI is a target of miR-155 in melanoma. However, impairment of SKI expression is not the leading mechanism involved in the growth-suppressive effect of miR-155 found in this malignancy. ..
  19. Rai D, Kim S, McKeller M, Dahia P, Aguiar R. Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc Natl Acad Sci U S A. 2010;107:3111-6 pubmed publisher
    ..Together, our data helped explain miR-155 function, highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology, and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects. ..
  20. Bruning U, Cerone L, Neufeld Z, Fitzpatrick S, Cheong A, Scholz C, et al. MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol Cell Biol. 2011;31:4087-96 pubmed publisher
  21. Habbe N, Koorstra J, Mendell J, Offerhaus G, Ryu J, Feldmann G, et al. MicroRNA miR-155 is a biomarker of early pancreatic neoplasia. Cancer Biol Ther. 2009;8:340-6 pubmed
    ..Misexpression of microRNAs (miRNAs) is commonly observed in pancreatic adenocarcinoma. In contrast, miRNA abnormalities in pancreatic cancer precursor lesions have not been documented...
  22. Leng R, Pan H, Qin W, Chen G, Ye D. Role of microRNA-155 in autoimmunity. Cytokine Growth Factor Rev. 2011;22:141-7 pubmed publisher
    ..This review will discuss the current understandings for the role of miR-155 in autoimmunity. ..
  23. Tili E, Michaille J, Wernicke D, Alder H, Costinean S, Volinia S, et al. Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer. Proc Natl Acad Sci U S A. 2011;108:4908-13 pubmed publisher
    ..Hence, we anticipate that the development of drugs reducing endogenous miR-155 levels might be key in the treatment of inflammation-related cancers. ..
  24. Cremer T, Fatehchand K, Shah P, Gillette D, Patel H, Marsh R, et al. MiR-155 induction by microbes/microbial ligands requires NF-?B-dependent de novo protein synthesis. Front Cell Infect Microbiol. 2012;2:73 pubmed publisher
    ..This study provides new insight into the complex regulation of miR-155 during microbial infection. ..
  25. Bakirtzi K, Hatziapostolou M, Karagiannides I, Polytarchou C, Jaeger S, Iliopoulos D, et al. Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors. Gastroenterology. 2011;141:1749-61.e1 pubmed publisher
    ..Levels of NTR1, miR-21, and miR-155 increase in human colon tumor samples and correlate with tumor stage. ..
  26. Faraoni I, Laterza S, Ardiri D, Ciardi C, Fazi F, Lo Coco F. MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status. J Hematol Oncol. 2012;5:26 pubmed publisher
  27. Dagan L, Jiang X, Bhatt S, Cubedo E, Rajewsky K, Lossos I. miR-155 regulates HGAL expression and increases lymphoma cell motility. Blood. 2012;119:513-20 pubmed publisher
    ..Furthermore, this effect may contribute to lymphoma cell dissemination and aggressiveness, characteristic of activated B cell-like diffuse large B-cell lymphoma typically expressing high levels of miR-155 and lacking HGAL expression. ..
  28. Kluiver J, Poppema S, de Jong D, Blokzijl T, Harms G, Jacobs S, et al. BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. J Pathol. 2005;207:243-9 pubmed
    ..Northern blot analysis showed expression of miR-155 in all DLBCL and PMBL derived cell lines and tissue samples analysed. In summary, we demonstrate expression of primary microRNA BIC and its derivative miR-155 in HL, PMBL and DLBCL. ..
  29. Marton S, Garcia M, Robello C, Persson H, Trajtenberg F, Pritsch O, et al. Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis. Leukemia. 2008;22:330-8 pubmed
    ..Predicted targets included several genes recently described as tumor suppressors. These data could afford new avenues for exploring innovative pathways in CLL biology and therapy. ..
  30. McClure L, Sullivan C. Kaposi's sarcoma herpes virus taps into a host microRNA regulatory network. Cell Host Microbe. 2008;3:1-3 pubmed publisher
    ..Two new papers provide strong evidence that a KSHV-encoded microRNA and mir-155 share a common set of mRNA targets and binding sites, implying a possible link between viral- and non-viral-mediated tumorigenesis. ..
  31. Thompson R, Herscovitch M, Zhao I, Ford T, Gilmore T. NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway. J Biol Chem. 2011;286:1675-82 pubmed publisher
    ..1, and consequently reduced CD10 mRNA and protein. ..
  32. Zhang C, Zhao J, Deng H. 17?-estradiol up-regulates miR-155 expression and reduces TP53INP1 expression in MCF-7 breast cancer cells. Mol Cell Biochem. 2013;379:201-11 pubmed publisher
  33. Louafi F, Martinez Nunez R, Sanchez Elsner T. MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}. J Biol Chem. 2010;285:41328-36 pubmed publisher
    ..Altogether, our data uncover an important role for miR-155 in modulating the cellular response to TGF-? with possible implications in several human diseases where homeostasis of TGF-? might be altered. ..
  34. Kutty R, Nagineni C, Samuel W, Vijayasarathy C, Hooks J, Redmond T. Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway. Biochem Biophys Res Commun. 2010;402:390-5 pubmed publisher
    ..in STAT1 activation as well as an increase in protein binding to putative STAT1 binding elements present in the MIR155 gene promoter region. All these activities were effectively blocked by JAK inhibitor 1...
  35. Vargova K, Curik N, Burda P, Basova P, Kulvait V, Pospisil V, et al. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. Blood. 2011;117:3816-25 pubmed publisher
    ..Our data provide evidence of oncogenic activities of MYB in B-CLL that include its stimulatory role in MIR155HG transcription. ..
  36. Boss I, Nadeau P, Abbott J, Yang Y, Mergia A, Renne R. A Kaposi's sarcoma-associated herpesvirus-encoded ortholog of microRNA miR-155 induces human splenic B-cell expansion in NOD/LtSz-scid IL2R?null mice. J Virol. 2011;85:9877-86 pubmed publisher
  37. Neilsen P, Noll J, Mattiske S, Bracken C, Gregory P, Schulz R, et al. Mutant p53 drives invasion in breast tumors through up-regulation of miR-155. Oncogene. 2013;32:2992-3000 pubmed publisher
    ..Collectively, these findings suggest that miR-155 targeted therapies may provide an attractive approach to treat mutant p53-expressing tumors. ..
  38. Du Z, Hu L, Wang H, Yan L, Zeng Y, Shao J, et al. Upregulation of MiR-155 in nasopharyngeal carcinoma is partly driven by LMP1 and LMP2A and downregulates a negative prognostic marker JMJD1A. PLoS ONE. 2011;6:e19137 pubmed publisher
    ..The potential of miR-155 and JMJD1A as therapeutic targets in NPC should be further investigated...
  39. Huang X, Shen Y, Liu M, Bi C, Jiang C, Iqbal J, et al. Quantitative proteomics reveals that miR-155 regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma. Am J Pathol. 2012;181:26-33 pubmed publisher
    ..Taken together, our results reveal a novel target involved in miR-155 biological characteristics and provide a molecular link between the overexpression of miR-155 and the activation of PI3K-AKT in DLBCL. ..
  40. Mar Aguilar F, Mendoza Ramírez J, Malagón Santiago I, Espino Silva P, Santuario Facio S, Ruiz Flores P, et al. Serum circulating microRNA profiling for identification of potential breast cancer biomarkers. Dis Markers. 2013;34:163-9 pubmed publisher
    ..miRNA profiling in serum has potential as a novel method for breast cancer detection in the Mexican population. ..
  41. Stanczyk J, Pedrioli D, Brentano F, Sanchez Pernaute O, Kolling C, Gay R, et al. Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum. 2008;58:1001-9 pubmed publisher
    ..Considering the repressive effect of miR-155 on the expression of MMPs 3 and 1 in RASFs, we hypothesize that miR-155 may be involved in modulation of the destructive properties of RASFs. ..
  42. Yin Q, Wang X, Fewell C, Cameron J, Zhu H, Baddoo M, et al. MicroRNA miR-155 inhibits bone morphogenetic protein (BMP) signaling and BMP-mediated Epstein-Barr virus reactivation. J Virol. 2010;84:6318-27 pubmed publisher
    ..These results suggest a role for miR-155 in controlling BMP-mediated cellular processes, in regulating BMP-induced EBV reactivation, and in the inhibition of antitumor effects of BMP signaling in normal and virus-infected cells. ..
  43. Ryu J, Hong S, Karikari C, Hruban R, Goggins M, Maitra A. Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma. Pancreatology. 2010;10:66-73 pubmed publisher
    ..01). Abnormalities of miRNA expression are observed in the multistep progression of pancreatic cancer, with miR-155 aberrations demonstrable at the stage of PanIN-2, and miR-21 abnormalities at the stage of PanIN-3 lesions. and IAP. ..
  44. Song J, Liu P, Yang Z, Li L, Su H, Lu N, et al. MiR-155 negatively regulates c-Jun expression at the post-transcriptional level in human dermal fibroblasts in vitro: implications in UVA irradiation-induced photoaging. Cell Physiol Biochem. 2012;29:331-40 pubmed publisher
    ..Our results demonstrate that miR-155 directly controls c-Jun expression in HDFs at the post-transcriptional level and might function as a protective miRNA in HDFs. ..
  45. Kong W, He L, Richards E, Challa S, Xu C, Permuth Wey J, et al. Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer. Oncogene. 2014;33:679-89 pubmed publisher
  46. Li S, Chen T, Zhong Z, Wang Y, Li Y, Zhao X. microRNA-155 silencing inhibits proliferation and migration and induces apoptosis by upregulating BACH1 in renal cancer cells. Mol Med Rep. 2012;5:949-54 pubmed publisher
    ..The suppression of miR-155 inhibited BACH1 protein expression. miR-155 may function as an oncogene by targeting BACH1. Thus, the inhibition of miR-155 may be an effective way to treat RCC. ..
  47. Lopez Ramirez M, Wu D, Pryce G, Simpson J, Reijerkerk A, King Robson J, et al. MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. FASEB J. 2014;28:2551-65 pubmed publisher
    ..We propose that brain endothelial miR-155 is a negative regulator of BBB function that may constitute a novel therapeutic target for CNS neuroinflammatory disorders. ..
  48. Xie Q, Chen X, Lu F, Zhang T, Hao M, Wang Y, et al. Aberrant expression of microRNA 155 may accelerate cell proliferation by targeting sex-determining region Y box 6 in hepatocellular carcinoma. Cancer. 2012;118:2431-42 pubmed publisher
    ..These findings suggest that miR-155 may be a potential target for HCC treatment. ..
  49. Dai Y, Diao Z, Sun H, Li R, Qiu Z, Hu Y. MicroRNA-155 is involved in the remodelling of human-trophoblast-derived HTR-8/SVneo cells induced by lipopolysaccharides. Hum Reprod. 2011;26:1882-91 pubmed publisher
    ..Our goal was to investigate the association of miR-155 with pre-eclampsia and the pathways involved using human-trophoblast-derived cell line (HTR-8/SVneo) stimulated with LPS...
  50. He M, Xu Z, Ding T, Kuang D, Zheng L. MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPbeta. Cell Mol Immunol. 2009;6:343-52 pubmed publisher
  51. Chen J, Wang B, Tang J. Clinical significance of microRNA-155 expression in human breast cancer. J Surg Oncol. 2012;106:260-6 pubmed publisher
    ..MiR-155 expression might be an independent prognostic factor and a therapeutic target for human breast cancer. ..
  52. Eis P, Tam W, Sun L, Chadburn A, Li Z, Gomez M, et al. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci U S A. 2005;102:3627-32 pubmed
    ..Because patients with activated B cell-type DLBCL have a poorer clinical prognosis, quantification of this microRNA may be diagnostically useful. ..
  53. Wan G, Xie W, Liu Z, Xu W, Lao Y, Huang N, et al. Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway. Autophagy. 2014;10:70-9 pubmed publisher
    ..Here, we describe hypoxia-induced MIR155 as a potent inducer of autophagy...
  54. Donnem T, Eklo K, Berg T, Sorbye S, Lonvik K, Al Saad S, et al. Prognostic impact of MiR-155 in non-small cell lung cancer evaluated by in situ hybridization. J Transl Med. 2011;9:6 pubmed publisher
    ..034) as well as in multivariate (HR 0.45, CI 95% 0.21-0.96, P = 0.039) analysis. The prognostic impact of miR-155 depends on histological subtype and nodal status in NSCLC. ..
  55. Linnstaedt S, Gottwein E, Skalsky R, Luftig M, Cullen B. Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus. J Virol. 2010;84:11670-8 pubmed publisher
  56. Gatto G, Rossi A, Rossi D, Kroening S, Bonatti S, Mallardo M. Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathway. Nucleic Acids Res. 2008;36:6608-19 pubmed publisher
    ..Finally, we demonstrate that LMP1-mediated activation of miR-155 in an EBV-negative background correlates with reduction of protein PU.1, which is a possible miR target. ..
  57. Metzler M, Wilda M, Busch K, Viehmann S, Borkhardt A. High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer. 2004;39:167-9 pubmed
  58. Ferrajoli A, Shanafelt T, Ivan C, Shimizu M, Rabe K, Nouraee N, et al. Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. Blood. 2013;122:1891-9 pubmed publisher
    ..Our findings support the use of cellular and plasma levels of miR-155 as biomarkers for the risk of progression in individuals with MBL, as well as to identify patients with CLL who may not respond well to therapy. ..
  59. Levati L, Alvino E, Pagani E, Arcelli D, Caporaso P, Bondanza S, et al. Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155. Int J Oncol. 2009;35:393-400 pubmed
    ..In conclusion, our data further support the finding of altered miRNA expression in melanoma cells and establish for the first time that miRNA-155 is a negative regulator of melanoma cell proliferation and survival. ..
  60. Tang B, Xiao B, Liu Z, Li N, Zhu E, Li B, et al. Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation. FEBS Lett. 2010;584:1481-6 pubmed publisher
    ..pylori infection. Thus, we have demonstrated that miR-155 can negatively regulate inflammation by targeting a key adaptor molecule MyD88 in inflammatory pathways. ..
  61. Wang J, Wu J. Role of miR-155 in breast cancer. Front Biosci (Landmark Ed). 2012;17:2350-5 pubmed
    ..This review summarizes the signaling pathways that are regulated by miR-155 in breast cancer and discusses therapeutic possibilities related to miR-155. ..
  62. Qin A, Zhou Y, Sheng M, Fei G, Ren T, Xu L. [Effects of microRNA-155 on the growth of human lung cancer cell line 95D ?in vitro]. Zhongguo Fei Ai Za Zhi. 2011;14:575-80 pubmed publisher
    ..05). miR-155 could significantly inhibit the growth of human lung cancer 95D cells in vitro, which might be closely related to miR-155 induced G0/G1 phase arrest. ..
  63. Zheng S, Guo G, Zhang W, Huang G, Hu X, Zhu J, et al. Clinical significance of miR-155 expression in breast cancer and effects of miR-155 ASO on cell viability and apoptosis. Oncol Rep. 2012;27:1149-55 pubmed publisher
    ..The Annexin V-FITC/PI assay also indicated that transfection with miR-155 ASO promoted apoptosis. ..
  64. Marcucci G, Maharry K, Metzeler K, Volinia S, Wu Y, Mrozek K, et al. Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients. J Clin Oncol. 2013;31:2086-93 pubmed publisher
    ..The availability of emerging compounds with antagonistic activity to microRNAs in the clinic provides the opportunity for future therapeutic targeting of miR-155 in AML. ..
  65. Wang H, Yu X, Liu Z, Cheng X, Samartzis D, Jia L, et al. Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3. J Pathol. 2011;225:232-42 pubmed publisher
    ..Our results suggest that deregulated miR-155 promotes Fas-mediated apoptosis in human IDD by targeting FADD and caspase-3, implicating an aetiological and therapeutic role of miR-155 in IDD. ..
  66. Cremer T, Ravneberg D, Clay C, Piper Hunter M, Marsh C, Elton T, et al. MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS ONE. 2009;4:e8508 pubmed publisher
    ..However, impaired miR-155 induction by SCHU S4 may help explain the lack of both SHIP down-regulation and pro-inflammatory response and may account for the virulence of Type A Francisella. ..
  67. Corsten M, Papageorgiou A, Verhesen W, Carai P, Lindow M, Obad S, et al. MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis. Circ Res. 2012;111:415-25 pubmed publisher
    ..The inflammatory microRNA-155 is upregulated during acute myocarditis, contributes to the adverse inflammatory response to viral infection of the heart, and is a potential therapeutic target for viral myocarditis. ..
  68. Pottier N, Maurin T, Chevalier B, Puissegur M, Lebrigand K, Robbe Sermesant K, et al. Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenchymal interactions. PLoS ONE. 2009;4:e6718 pubmed publisher
    ..Altogether, this study implicates this miRNA in the regulation by mesenchymal cells of surrounding lung epithelium, making it a potential key player during tissue injury. ..
  69. Zhu J, Hu X, Guo G, Zhang Y, Wang O, You J, et al. [Expression and its clinical significance of miR-155 in human primary breast cancer]. Zhonghua Wai Ke Za Zhi. 2010;48:205-8 pubmed
    ..miR-155 may play an important role in the proliferation, invasion and metastasis of human primary breast cancer, and it could be a indicator in the diagnosis and prognosis of primary breast cancer. ..
  70. Rahadiani N, Takakuwa T, Tresnasari K, Morii E, Aozasa K. Latent membrane protein-1 of Epstein-Barr virus induces the expression of B-cell integration cluster, a precursor form of microRNA-155, in B lymphoma cell lines. Biochem Biophys Res Commun. 2008;377:579-583 pubmed publisher
    ..These results suggest that BIC/miR-155 play a role in lymphomagenesis through NF-kappaB and p38/MAPK pathways in response to activation by EBV LMP1...
  71. Shibuya H, Iinuma H, Shimada R, Horiuchi A, Watanabe T. Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer. Oncology. 2010;79:313-20 pubmed publisher
    ..Significant inverse correlations were demonstrated between miR-21 and PDCD4 mRNA, and miR-155 and TP53INP1 mRNA. Increases in miR-21 and miR-155 expression may represent effective biomarkers for the prediction of a poor prognosis. ..