MIR132

Summary

Gene Symbol: MIR132
Description: microRNA 132
Alias: MIRN132, miRNA132
Species: human
Products:     MIR132

Top Publications

  1. Wayman G, Davare M, Ando H, Fortin D, Varlamova O, Cheng H, et al. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci U S A. 2008;105:9093-8 pubmed publisher
    ..Here, we show that microRNA 132 (miR132) is an activity-dependent rapid response gene regulated by the cAMP response element-binding (CREB) protein ..
  2. Formosa A, Lena A, Markert E, Cortelli S, Miano R, Mauriello A, et al. DNA methylation silences miR-132 in prostate cancer. Oncogene. 2013;32:127-34 pubmed publisher
    ..The results of this study point to miR-132 as a methylation-silenced miRNA with an antimetastatic role in PCa controlling cellular adhesion. ..
  3. Yang J, Gao T, Tang J, Cai H, Lin L, Fu S. Loss of microRNA-132 predicts poor prognosis in patients with primary osteosarcoma. Mol Cell Biochem. 2013;381:9-15 pubmed publisher
    ..006). These findings offer the convinced evidence for the first time that miR-132 may participate in tumor progression of osteosarcoma and loss of miR-132 expression may be a predictor for unfavorable outcome of osteosarcoma patients. ..
  4. Katare R, Riu F, Mitchell K, Gubernator M, Campagnolo P, Cui Y, et al. Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circ Res. 2011;109:894-906 pubmed publisher
    ..SVP transplantation produces long-term improvement of cardiac function through a novel paracrine mechanism involving the secretion of miR-132 and inhibition of its target genes. ..
  5. Park J, Henry J, Jiang J, Esau C, Gusev Y, Lerner M, et al. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun. 2011;406:518-23 pubmed publisher
    ..The ?2 adrenergic pathway may play an important role in this novel mechanism. ..
  6. Li S, Meng H, Zhou F, Zhai L, Zhang L, Gu F, et al. MicroRNA-132 is frequently down-regulated in ductal carcinoma in situ (DCIS) of breast and acts as a tumor suppressor by inhibiting cell proliferation. Pathol Res Pract. 2013;209:179-83 pubmed publisher
    ..High expression of miR-132 could also inhibit the colony formation. Our findings will lead to further understanding of the development of breast cancer. ..
  7. Eskildsen T, Jeppesen P, Schneider M, Nossent A, Sandberg M, Hansen P, et al. Angiotensin II regulates microRNA-132/-212 in hypertensive rats and humans. Int J Mol Sci. 2013;14:11190-207 pubmed publisher
    ..Taken together, these data suggest that miR-132 and miR-212 are involved in AngII induced hypertension, providing a new perspective in hypertensive disease mechanisms. ..
  8. Zhang S, Hao J, Xie F, Hu X, Liu C, Tong J, et al. Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development. Carcinogenesis. 2011;32:1183-9 pubmed publisher
    ..Our present findings illustrate the mechanism driving miR-132 downregulation and the important role of miR-132 in pancreatic cancer development. ..
  9. Anand S, Majeti B, Acevedo L, Murphy E, Mukthavaram R, Scheppke L, et al. MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat Med. 2010;16:909-14 pubmed publisher

More Information

Publications79

  1. Strum J, Johnson J, Ward J, Xie H, Feild J, Hester A, et al. MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1. Mol Endocrinol. 2009;23:1876-84 pubmed publisher
  2. Miller B, Zeier Z, Xi L, Lanz T, Deng S, Strathmann J, et al. MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function. Proc Natl Acad Sci U S A. 2012;109:3125-30 pubmed publisher
    ..Our data suggest miR-132 dysregulation and subsequent abnormal expression of miR-132 target genes contribute to the neurodevelopmental and neuromorphological pathologies present in schizophrenia. ..
  3. Cheng H, Papp J, Varlamova O, Dziema H, Russell B, Curfman J, et al. microRNA modulation of circadian-clock period and entrainment. Neuron. 2007;54:813-29 pubmed
    ..Collectively, these data reveal miRNAs as clock- and light-regulated genes and provide a mechanistic examination of their roles as effectors of pacemaker activity and entrainment. ..
  4. Wong H, Veremeyko T, Patel N, Lemere C, Walsh D, Esau C, et al. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Hum Mol Genet. 2013;22:3077-92 pubmed publisher
    ..These results indicate that the miR-132/miR-212/PTEN/FOXO3a signaling pathway contributes to AD neurodegeneration. ..
  5. Wei X, Tan C, Tang C, Ren G, Xiang T, Qiu Z, et al. Epigenetic repression of miR-132 expression by the hepatitis B virus x protein in hepatitis B virus-related hepatocellular carcinoma. Cell Signal. 2013;25:1037-43 pubmed publisher
    ..formation of HCC cells were found to be suppressed by miR-132-mediated inhibition of the Akt-signaling pathway in miR132 transfected cells...
  6. Sadegh M, Ekman M, Krawczyk K, Svensson D, Göransson O, Dahan D, et al. Detrusor induction of miR-132/212 following bladder outlet obstruction: association with MeCP2 repression and cell viability. PLoS ONE. 2015;10:e0116784 pubmed publisher
    ..In all, these findings show that obstruction of the urethra increases miR-132 and miR-212 in the detrusor and suggests that this influences gene expression and limits cell growth. ..
  7. Zhang B, Lu L, Zhang X, Ye W, Wu J, Xi Q, et al. Hsa-miR-132 regulates apoptosis in non-small cell lung cancer independent of acetylcholinesterase. J Mol Neurosci. 2014;53:335-44 pubmed publisher
    ..Interestingly, hsa-miR-132 has no pro-apoptotic effect in normal pulmonary trachea epithelium. Taken together, these results suggest that hsa-miR-132 represses NSCLC growth by inducing apoptosis independent of AChE. ..
  8. Cai Y, Huang G, Ma L, Dong L, Chen S, Shen X, et al. Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition. Biochim Biophys Acta Mol Cell Res. 2018;1865:297-308 pubmed publisher
    ..In addition, Smurf2 activated cAMP-PKA-CREB pathway by interacting with phosphodiesterase 4B (PDE4B) and facilitating its degradation. Thus, we have demonstrated a previously unrecognized anti-fibrotic pathway controlled by Smurf2. ..
  9. Li G, Liu K, Du X. Long Non-Coding RNA TUG1 Promotes Proliferation and Inhibits Apoptosis of Osteosarcoma Cells by Sponging miR-132-3p and Upregulating SOX4 Expression. Yonsei Med J. 2018;59:226-235 pubmed publisher
    ..TUG1 facilitated proliferation and suppressed apoptosis by regulating the miR-132-3p/SOX4 axis in human OS cell lines and primary OS cells. This finding provides a potential target for OS therapy. ..
  10. Kiga K, Fukuda Yuzawa Y, Tanabe M, Tsuji S, Sasakawa C, Fukao T. Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer. RNA Biol. 2014;11:1347-54 pubmed publisher
    ..Our work also provides an example where epigenetic mechanisms cause the group-wide regulation of miRNAs sharing a common key target. ..
  11. Dal Bo M, D Agaro T, Gobessi S, Zucchetto A, Dereani S, Rossi D, et al. The SIRT1/TP53 axis is activated upon B-cell receptor triggering via miR-132 up-regulation in chronic lymphocytic leukemia cells. Oncotarget. 2015;6:19102-17 pubmed
    ..41; P = 0.02). Collectively, the miR-132/SIRT1/TP53 axis was identified as a novel pathway triggered by BCR engagement that further increases the complexity of the interactions between tumor microenvironments and CLL cells. ..
  12. Xiao J, Li Y, Prandovszky E, Karuppagounder S, Talbot C, Dawson V, et al. MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway. Neuroscience. 2014;268:128-38 pubmed publisher
    ..Our findings provide a possible mechanism for how the parasite contributes to the neuropathology of infection. ..
  13. Weber D, Gawrych K, Casjens S, Brik A, Lehnert M, Taeger D, et al. Circulating miR-132-3p as a Candidate Diagnostic Biomarker for Malignant Mesothelioma. Dis Markers. 2017;2017:9280170 pubmed publisher
    ..It is indicated that the combination of miR-132-3p with other individual biomarkers improves the biomarker performance. ..
  14. Jiang X, Chen X, Chen L, Ma Y, Zhou L, Qi Q, et al. Upregulation of the miR-212/132 cluster suppresses proliferation of human lung cancer cells. Oncol Rep. 2015;33:705-12 pubmed publisher
    ..Our study provides insight into the biological function of the miR-212/132 cluster in lung cancer. The present study may provide a potential therapeutic target for the treatment of lung cancer. ..
  15. Kumarswamy R, Volkmann I, Beermann J, Napp L, Jabs O, Bhayadia R, et al. Vascular importance of the miR-212/132 cluster. Eur Heart J. 2014;35:3224-31 pubmed publisher
  16. Leinders M, Üçeyler N, Pritchard R, Sommer C, Sorkin L. Increased miR-132-3p expression is associated with chronic neuropathic pain. Exp Neurol. 2016;283:276-86 pubmed publisher
    ..001). Intrathecal administration of miR-132-3p mimetic dose-dependently induced pain behavior in naïve rats (p<0.001). Taken together these results indicate a pro-nociceptive effect of miR-132-3p in chronic neuropathic pain. ..
  17. Lin H, Mahon K, Spielman C, Gurney H, Mallesara G, Stockler M, et al. Phase 2 study of circulating microRNA biomarkers in castration-resistant prostate cancer. Br J Cancer. 2017;116:1002-1011 pubmed publisher
    ..20-7.70, P=0.000001). The signature was an independent predictor in multivariable analysis with clinicopathological factors. The association of circulating microRNAs with overall survival suggests their involvement in CRPC progression. ..
  18. Li X, Li D, Wang A, Chu T, Lohcharoenkal W, Zheng X, et al. MicroRNA-132 with Therapeutic Potential in Chronic Wounds. J Invest Dermatol. 2017;137:2630-2638 pubmed publisher
    ..Together, our study showed the therapeutic potential of miR-132 in chronic wounds, which warrants further evaluation in controlled clinical trials. ..
  19. Nahid M, Yao B, Dominguez Gutierrez P, Kesavalu L, Satoh M, Chan E. Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212. J Immunol. 2013;190:1250-63 pubmed publisher
  20. Renjie W, Haiqian L. MiR-132, miR-15a and miR-16 synergistically inhibit pituitary tumor cell proliferation, invasion and migration by targeting Sox5. Cancer Lett. 2015;356:568-78 pubmed publisher
    ..In conclusion, our data indicate that miR-132 and miR-15a/16 act as tumor suppressor genes in pituitary tumor by directly targetting Sox5, and imply that these miRNAs have potential as therapeutic targets for invasive pituitary tumor. ..
  21. Huang Y, Lei Y, Zhang H, Hou L, Zhang M, Dayton A. MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of IL-12 signaling in human natural killer cells. Blood. 2011;118:6793-802 pubmed publisher
    ..These data suggest that miR-132, -212, and -200a up-regulation during prolonged IL-12 treatment, negatively regulates the IL-12 signaling pathway by reducing STAT4 expression in primary human NK cells. ..
  22. He L, Qu L, Wei L, Chen Y, Suo J. Reduction of miR?132?3p contributes to gastric cancer proliferation by targeting MUC13. Mol Med Rep. 2017;15:3055-3061 pubmed publisher
    ..In summary, reduction of miR?132?3p may contribute to gastric cancer proliferation by targeting MUC13. ..
  23. Lozoya T, Dominguez F, Romero Ruiz A, Steffani L, Martínez S, Monterde M, et al. The Lin28/Let-7 system in early human embryonic tissue and ectopic pregnancy. PLoS ONE. 2014;9:e87698 pubmed publisher
    ..This finding suggests the potential involvement of LIN28B/Let-7 (de)regulated pathways in the pathophysiology of ectopic pregnancy in humans. ..
  24. Pauley K, Satoh M, Chan A, Bubb M, Reeves W, Chan E. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther. 2008;10:R101 pubmed publisher
  25. Li D, Wang A, Liu X, Meisgen F, Grünler J, Botusan I, et al. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing. J Clin Invest. 2015;125:3008-26 pubmed publisher
    ..Together, our results indicate that miR-132 is a critical regulator of skin wound healing that facilitates the transition from the inflammatory to the proliferative phase. ..
  26. Loginov V, Burdennyy A, Pronina I, Khokonova V, Kurevljov S, Kazubskaya T, et al. [Novel miRNA genes hypermethylated in breast cancer]. Mol Biol (Mosk). 2016;50:797-802 pubmed
    ..These results enable the involvement of three miRNAs (miR-132, miR-137, miR-1258) and the methylation of the genes that encode them in the pathogenesis of breast cancer to be suggested. ..
  27. Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed publisher
    ..We confirm downregulation of miR-132 and upregulation of ITPKB in three distinct human AD patient cohorts, indicating the pathological relevance of this pathway in AD. ..
  28. Yu H, Wu J, Zhang H, Zhang G, Sui J, Tong W, et al. Alterations of miR-132 are novel diagnostic biomarkers in peripheral blood of schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry. 2015;63:23-9 pubmed publisher
    ..05) of the SCZ-like rats compared to controls. For the first time, our results suggest that miR-132 is a potential and superior biomarker in peripheral blood that will allow discrimination of SCZ patients from healthy controls. ..
  29. Liu X, Yan S, Pei C, Cui Y. Decreased microRNA-132 and its function in human non-small cell lung cancer. Mol Med Rep. 2015;11:3601-8 pubmed publisher
    ..These findings indicate that miR‑132 may be a novel diagnostic and prognostic marker, as well as a potential target for molecular therapy in NSCLC. ..
  30. Lian R, Lu B, Jiao L, Li S, Wang H, Miao W, et al. MiR-132 plays an oncogenic role in laryngeal squamous cell carcinoma by targeting FOXO1 and activating the PI3K/AKT pathway. Eur J Pharmacol. 2016;792:1-6 pubmed publisher
    ..Therefore, miR-132 might be a potential therapeutic strategy in LSCC. ..
  31. Zhang L, Huang D, Wang Q, Shen D, Wang Y, Chen B, et al. MiR-132 inhibits expression of SIRT1 and induces pro-inflammatory processes of vascular endothelial inflammation through blockade of the SREBP-1c metabolic pathway. Cardiovasc Drugs Ther. 2014;28:303-11 pubmed publisher
    ..Inhibition of SIRT1 by miR-132 was associated with lipid metabolism-dependent pro-inflammatory processes in HUVECs. The newly identified miRNA, miR-132 represents a novel targeting mechanism for AS therapy. ..
  32. Lagos D, Pollara G, Henderson S, Gratrix F, Fabani M, Milne R, et al. miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator. Nat Cell Biol. 2010;12:513-9 pubmed publisher
    ..By targeting p300, rather than a transcription factor or signalling protein, miR-132 has a broad role in the regulation of antiviral immunity. ..
  33. Zheng Y, Luo H, Shi Q, Hao Z, Ding Y, Wang Q, et al. miR-132 inhibits colorectal cancer invasion and metastasis via directly targeting ZEB2. World J Gastroenterol. 2014;20:6515-22 pubmed publisher
    ..Further investigation revealed ZEB2, an EMT regulator, was a downstream target of miR-132. Our study indicated that miR-132 plays an important role in the invasion and metastasis of CRC. ..
  34. Zhang Z, Chen W, Wu Y, Liang H, Zhang B. MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1. Biochem Biophys Res Commun. 2014;454:109-14 pubmed publisher
  35. Kim H, Kwon H, Ha Thi H, Lee H, Kim G, Hahm K, et al. MicroRNA-132 and microRNA-223 control positive feedback circuit by regulating FOXO3a in inflammatory bowel disease. J Gastroenterol Hepatol. 2016;31:1727-1735 pubmed publisher
  36. Wang R, Liang H, Li H, Dou H, Zhang M, Baobuhe -, et al. USF-1 inhibition protects against oxygen-and-glucose-deprivation-induced apoptosis via the downregulation of miR-132 in HepG2 cells. Biochem Biophys Res Commun. 2014;446:1053-9 pubmed publisher
  37. Molnar V, Ersek B, Wiener Z, Tömböl Z, Szabó P, Igaz P, et al. MicroRNA-132 targets HB-EGF upon IgE-mediated activation in murine and human mast cells. Cell Mol Life Sci. 2012;69:793-808 pubmed publisher
    ..Our data provide a novel example for negative regulation of a growth factor by an upregulated miRNA. ..
  38. Hanieh H. Aryl hydrocarbon receptor-microRNA-212/132 axis in human breast cancer suppresses metastasis by targeting SOX4. Mol Cancer. 2015;14:172 pubmed publisher
    ..Also, current study suggest a new miRNA-based mechanism elucidating the anti-metastatic properties of Ahr agonists, suggesting possibility of using miR-212/132 to control metastasis in breast cancer patients. ..
  39. Wang J, Xu G, Shen F, Kang Y. miR-132 targeting cyclin E1 suppresses cell proliferation in osteosarcoma cells. Tumour Biol. 2014;35:4859-65 pubmed publisher
    ..Taken together, these results indicate that miR-132 functions as a tumor suppressor in osteosarcoma and that its suppressive effects are mediated chiefly by repressing CCNE1 expression. ..
  40. Liu W, Xia P, Feng J, Kang L, Huang M, Wang K, et al. MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration. Exp Cell Res. 2017;359:39-49 pubmed publisher
    ..Our findings demonstrated that miR-132 promotes ECM degradation by human NP cells by direct targeting of GDF5. Hence, miR-132 represents a potential therapeutic target in the treatment of IDD. ..
  41. Das Gupta M, Fliesser M, Springer J, Breitschopf T, Schlossnagel H, Schmitt A, et al. Aspergillus fumigatus induces microRNA-132 in human monocytes and dendritic cells. Int J Med Microbiol. 2014;304:592-6 pubmed publisher
    ..Interestingly, miR-132 was induced by A. fumigatus but not by LPS in both cell types. Our data suggest that miR-132 may be a relevant regulator of the immune response directed against A. fumigatus. ..
  42. Leonov G, Shah K, Yee D, Timmis J, Sharp T, Lagos D. Suppression of AGO2 by miR-132 as a determinant of miRNA-mediated silencing in human primary endothelial cells. Int J Biochem Cell Biol. 2015;69:75-84 pubmed publisher
    ..Our data demonstrate that the miRNA-silencing machinery is subject to autoregulation during primary cell activation through direct suppression of AGO2 by miR-132. ..
  43. Lei C, Li L, Gao X, Zhang J, Pan Q, Long H, et al. Hsa-miR-132 inhibits proliferation of hepatic carcinoma cells by targeting YAP. Cell Biochem Funct. 2015;33:326-33 pubmed publisher
    ..Taken together, results from this study would help us to understand the mechanisms for occurrence and development of hepatic carcinoma and provide new targets for diagnosis and treatment of liver cancer. ..
  44. Smith P, Hernandez Rapp J, Jolivette F, Lecours C, Bisht K, Goupil C, et al. miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo. Hum Mol Genet. 2015;24:6721-35 pubmed publisher
    ..These findings support a role for miR-132/212 in the regulation of tau pathology in mice and humans and provide new alternatives for therapeutic development. ..
  45. Rawal S, Munasinghe P, Shindikar A, Paulin J, Cameron V, Manning P, et al. Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. Cardiovasc Res. 2017;113:90-101 pubmed publisher
    ..Therefore, therapeutic restoration of angiomiRs could become a potential approach to combat the cardiovascular complications of diabetes. ..
  46. Chiang K, Liu H, Rice A. miR-132 enhances HIV-1 replication. Virology. 2013;438:1-4 pubmed publisher
    ..Knockdown of MeCP2, a previously identified target of miR-132, also increases HIV-1 replication. To the best of our knowledge, miR-132 is the first miRNA reported to enhance HIV-1 replication. ..
  47. Guo X, Zhang D, Fan Y, Qin L, Dong S, Zhang L. Upregulated miR-132 in Lgr5+ gastric cancer stem cell-like cells contributes to cisplatin-resistance via SIRT1/CREB/ABCG2 signaling pathway. Mol Carcinog. 2017;56:2022-2034 pubmed publisher
    ..Thus, we concluded that miR-132 regulated SIRT1/CREB/ABCG2 signaling pathway contributing to the cisplatin resistance and might serve as a novel therapeutic target against gastric cancer. ..
  48. Kim H, Hwang S, Shin C, Choi K, Ohn T, Kim H. SRSF3-regulated miR-132/212 controls cell migration and invasion by targeting YAP1. Exp Cell Res. 2017;358:161-170 pubmed publisher
  49. You J, Li Y, Fang N, Liu B, Zu L, Chang R, et al. MiR-132 suppresses the migration and invasion of lung cancer cells via targeting the EMT regulator ZEB2. PLoS ONE. 2014;9:e91827 pubmed publisher
    ..Thus, our finding provides new insight into the mechanism of NSCLC progression. Therapeutically, miR-132 may serve as a potential target in the treatment of human lung cancer. ..
  50. Zhu Q, Unmehopa U, Bossers K, Hu Y, Verwer R, Balesar R, et al. MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. Brain. 2016;139:908-21 pubmed publisher
  51. Wang Z, Zhang Q, Duan Y, Zhang J, Li G, Zheng D. TGF-β induced miR-132 enhances the activation of TGF-β signaling through inhibiting SMAD7 expression in glioma cells. Biochem Biophys Res Commun. 2015;463:187-92 pubmed publisher
    ..These findings contribute to a better understanding of the mechanism of the activation of TGF-β signaling by miR-132. ..
  52. Smith P, Delay C, Girard J, Papon M, Planel E, Sergeant N, et al. MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy. Hum Mol Genet. 2011;20:4016-24 pubmed publisher
    ..Taken together, these results suggest that changes in the miR-132/PTBP2 pathway could contribute to the abnormal splicing of tau exon 10 in the brain, and sheds light into the potential role played by miRNAs in a subset of tauopathies. ..
  53. Rider C, Yamamoto M, Günther O, Hirota J, Singh A, Tebbutt S, et al. Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers. J Allergy Clin Immunol. 2016;138:1690-1700 pubmed publisher
    ..In silico analysis suggested a possible mechanism contributing to epithelial wall damage following allergen exposure. ..
  54. Miyazaki Y, Li R, Rezk A, Misirliyan H, Moore C, Farooqi N, et al. A novel microRNA-132-sirtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis [corrected]. PLoS ONE. 2014;9:e105421 pubmed publisher
  55. Pichler S, Gu W, Hartl D, Gasparoni G, Leidinger P, Keller A, et al. The miRNome of Alzheimer's disease: consistent downregulation of the miR-132/212 cluster. Neurobiol Aging. 2017;50:167.e1-167.e10 pubmed publisher
    ..This miRNome-wide study in AD provides supportive evidence and corroborates an important contribution of miR-132/212 and corresponding target mRNAs to the pathogenesis of AD. ..
  56. Geng F, Wu J, Lu G, Liang Z, Duan Z, Gu X. MicroRNA-132 targets PEA-15 and suppresses the progression of astrocytoma in vitro. J Neurooncol. 2016;129:211-20 pubmed publisher
  57. Qi L, Zhang Y. The microRNA 132 regulates fluid shear stress-induced differentiation in periodontal ligament cells through mTOR signaling pathway. Cell Physiol Biochem. 2014;33:433-45 pubmed publisher
    ..Our data support the hypothesis that FSS-induced differentiation and proliferation involves the PI3K/AKT/mTOR signaling axis, through a process involving mir-132. ..
  58. Zhao J, Zhang L, Guo X, Wang J, Zhou W, Liu M, et al. miR-212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical cancer cells. IUBMB Life. 2015;67:380-94 pubmed publisher
    ..Importantly, SMAD2 overexpression partially reversed the cellular phenotypes induced by miR-212/132 overexpression. In conclusion, our study indicated that miR-212/132 functions as tumor suppressor by targeting SMAD2 in cervical cancer. ..
  59. Zhang X, Tang W, Chen G, Ren F, Liang H, Dang Y, et al. An Encapsulation of Gene Signatures for Hepatocellular Carcinoma, MicroRNA-132 Predicted Target Genes and the Corresponding Overlaps. PLoS ONE. 2016;11:e0159498 pubmed publisher
    ..However, combined detections of miR-132 with other bio-indicators in clinical practice and further in vitro experiments are needed. ..
  60. Huang S, Zhao J, Huang D, Zhuo L, Liao S, Jiang Z. Serum miR-132 is a risk marker of post-stroke cognitive impairment. Neurosci Lett. 2016;615:102-6 pubmed publisher
    ..Because of the limitations of this study, the results should be treated with caution. ..
  61. Walker R, Rybka J, Anderson S, Torrance H, Boxall R, Sussmann J, et al. Preliminary investigation of miRNA expression in individuals at high familial risk of bipolar disorder. J Psychiatr Res. 2015;62:48-55 pubmed publisher
    ..Moreover, our observation of altered miRNA expression in the blood prior to the onset of illness provides hope that one day blood-based tests may aid in the risk-stratification and treatment of BD. ..
  62. Ni B, Rajaram M, Lafuse W, Landes M, Schlesinger L. Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a. J Immunol. 2014;193:4537-47 pubmed publisher
    ..Collectively, these data validate p300 as a target of miR-132 and miR-26a, and demonstrate a mechanism by which M. tuberculosis can limit macrophage responses to IFN-γ by altering host miRNA expression. ..
  63. Liu Y, Li Y, Liu J, Wu Y, Zhu Q. MicroRNA-132 inhibits cell growth and metastasis in osteosarcoma cell lines possibly by targeting Sox4. Int J Oncol. 2015;47:1672-84 pubmed publisher
    ..In conclusion, miR‑132 inhibited cell growth and metastasis in osteosarcoma cells by downregulation of Sox4, and knockdown of Sox4 was essential for the miR-132-inhibited cell growth and metastasis in osteosarcoma cells. ..
  64. Wu R, Li F, Zhu J, Tang R, Qi Q, Zhou X, et al. A functional variant at miR-132-3p, miR-212-3p, and miR-361-5p binding site in CD80 gene alters susceptibility to gastric cancer in a Chinese Han population. Med Oncol. 2014;31:60 pubmed publisher
    ..Our findings have shown that the SNP rs1599795 in CD80 3'-UTR, through disrupting the regulatory role of miR-132-3p, miR-212-3p, and miR-361-5p in CD80 expression, contributed to the occurrence of gastric cancer. ..
  65. Liu X, Yu H, Cai H, Wang Y. The expression and clinical significance of miR-132 in gastric cancer patients. Diagn Pathol. 2014;9:57 pubmed publisher
    ..020). miR-132 could serve as an efficient prognostic factor for gastric cancer patients. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8168577241196050. ..
  66. Chen S, Wang Y, Ni C, Meng G, Sheng X. HLF/miR-132/TTK axis regulates cell proliferation, metastasis and radiosensitivity of glioma cells. Biomed Pharmacother. 2016;83:898-904 pubmed publisher
    ..TTK acts as an oncogene in glioma. HLF-mediated miR-132 directly suppresses TTK expression, thus exerting inhibitory effects on cancer cell proliferation, metastasis and radioresistance. ..
  67. Sun X, Zhang J, Niu W, Guo W, Song H, Li H, et al. A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2015;168B:170-8 pubmed publisher
    ..Markers miR-132, miR-181b, miR-30e and miR-432 are potential indicators for symptomatology improvements, treatment responses and prognosis for schizophrenia patients. ..
  68. Xie B, Zhou H, Zhang R, Song M, Yu L, Wang L, et al. Serum miR-206 and miR-132 as Potential Circulating Biomarkers for Mild Cognitive Impairment. J Alzheimers Dis. 2015;45:721-31 pubmed publisher
    ..These results preliminarily indicated that circulating miR-206 and miR-132 as novel miRNAs upregulated in MCI patient were potential biomarkers for diagnosis of MCI. ..
  69. Maharshak N, Shenhar Tsarfaty S, Aroyo N, Orpaz N, Guberman I, Canaani J, et al. MicroRNA-132 modulates cholinergic signaling and inflammation in human inflammatory bowel disease. Inflamm Bowel Dis. 2013;19:1346-53 pubmed publisher
    ..24, P = 0.046). Taken together, these findings support an inflammation-dependent homeostatic role for the regulation by miR-132 of AChE in IBD, opening new venues for therapeutic interference. ..
  70. Mokutani Y, Uemura M, Munakata K, Okuzaki D, Haraguchi N, Takahashi H, et al. Down-Regulation of microRNA-132 is Associated with Poor Prognosis of Colorectal Cancer. Ann Surg Oncol. 2016;23:599-608 pubmed
    ..0344). Down-regulation of miR-132 is associated with poor prognosis in CRC. ANO1 could be one of the crucial targets of miR-132 in CRC. ..