Gene Symbol: MIR127
Description: microRNA 127
Alias: MIRN127, miRNA127
Species: human

Top Publications

  1. Song G, Wang L. A conserved gene structure and expression regulation of miR-433 and miR-127 in mammals. PLoS ONE. 2009;4:e7829 pubmed publisher
    ..Our studies for the first time demonstrate a conserved gene structure and transcriptional regulation of miR-433 and miR-127 in mammals. The data suggest that the miR-433/127 loci may have evolved from a common gene of origin. ..
  2. Robertus J, Harms G, Blokzijl T, Booman M, de Jong D, Van Imhoff G, et al. Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma. Mod Pathol. 2009;22:547-55 pubmed publisher
    ..05). We conclude that the location of diffuse large B-cell lymphoma is an important factor in determining the differential expression of miRNAs. ..
  3. Leucci E, Onnis A, Cocco M, De Falco G, Imperatore F, Giuseppina A, et al. B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-altered expression. Int J Cancer. 2010;126:1316-26 pubmed publisher
    ..The overexpression of this miRNA may thus represent a key event in the lymphomagenesis of EBV positive BL, by blocking the B-cell differentiation process. ..
  4. Yang Z, Zhang Y, Wang L. A feedback inhibition between miRNA-127 and TGFβ/c-Jun cascade in HCC cell migration via MMP13. PLoS ONE. 2013;8:e65256 pubmed publisher
    ..This is the first report elucidating a feedback regulation between miR-127 and the TGFβ/c-Jun cascade in HCC migration via MMP13 that involves a crosstalk between the oncogene c-Jun and tumor suppressor p53. ..
  5. Hua W, Wu X, Zhang Y, Song Y, Tu J, Kang L, et al. Dysregulated miR-127-5p contributes to type II collagen degradation by targeting matrix metalloproteinase-13 in human intervertebral disc degeneration. Biochimie. 2017;139:74-80 pubmed publisher
    ..Dysregulated miR-127-5p contributed to the degradation of type II collagen by targeting MMP-13 in human IDD. Our findings highlight that miR-127-5p may serve as a new therapeutic target in IDD. ..
  6. Zhang J, Hou W, Chai M, Zhao H, Jia J, Sun X, et al. MicroRNA-127-3p inhibits proliferation and invasion by targeting SETD8 in human osteosarcoma cells. Biochem Biophys Res Commun. 2016;469:1006-11 pubmed publisher
  7. Herr I, Sähr H, Zhao Z, Yin L, Omlor G, Lehner B, et al. MiR-127 and miR-376a act as tumor suppressors by in vivo targeting of COA1 and PDIA6 in giant cell tumor of bone. Cancer Lett. 2017;409:49-55 pubmed publisher
    ..7% and 42.7%, while the tumor take rates remained stable. Our results indicate that re-expression of miR-127-3p and miR-376a-3p induces a strong tumor suppressor effect in GCTSC, which is partially mediated via COA1 and PDIA6. ..
  8. Afanasyeva E, Hotz Wagenblatt A, Glatting K, Westermann F. New miRNAs cloned from neuroblastoma. BMC Genomics. 2008;9:52 pubmed publisher
    ..Some of these newly identified sequences reside within frequently altered chromosomal regions in NB tumours and may play a role in NB biology. ..
  9. Park S, Cheon E, Lee M, Kim H. MicroRNA-127-5p regulates matrix metalloproteinase 13 expression and interleukin-1?-induced catabolic effects in human chondrocytes. Arthritis Rheum. 2013;65:3141-52 pubmed publisher
    ..MicroRNA-127-5p is an important regulator of MMP-13 in human chondrocytes and may contribute to the development of OA. ..

More Information


  1. Jiang H, Hua D, Zhang J, Lan Q, Huang Q, Yoon J, et al. MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7. Oncol Rep. 2014;31:2261-9 pubmed publisher
    ..In addition, microarray analysis revealed that miR-127-3p regulated a number of migration and invasion-related genes. Finally, we verified that miR-127-3p affected the remodeling of the actin cytoskeleton mediated by SEPT7 in GBM cells. ..
  2. Huan L, Bao C, Chen D, Li Y, Lian J, Ding J, et al. MicroRNA-127-5p targets the biliverdin reductase B/nuclear factor-κB pathway to suppress cell growth in hepatocellular carcinoma cells. Cancer Sci. 2016;107:258-66 pubmed publisher
  3. Willers I, Martínez Reyes I, Martínez Diez M, Cuezva J. miR-127-5p targets the 3'UTR of human ?-F1-ATPase mRNA and inhibits its translation. Biochim Biophys Acta. 2012;1817:838-48 pubmed publisher
  4. Guo L, Li H, Wang F, Yu J, He J. The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. Int J Mol Sci. 2013;14:14171-84 pubmed publisher
    ..Taken together, our results showed that miR-433 and miR-127 might act as tumor suppressors in GC, and it may provide novel diagnostic and therapeutic options for human GC clinical operation in the near future. ..
  5. Pronina I, Loginov V, Burdennyy A, Fridman M, Senchenko V, Kazubskaya T, et al. DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. Gene. 2017;604:1-8 pubmed publisher
  6. Gao X, Wang X, Cai K, Wang W, Ju Q, Yang X, et al. MicroRNA-127 is a tumor suppressor in human esophageal squamous cell carcinoma through the regulation of oncogene FMNL3. Eur J Pharmacol. 2016;791:603-610 pubmed publisher
    ..These results suggest that miR-127 is downregulated and acting as tumor suppressor in ESCC. Inversely, FMNL3, the target gene of miR-127, is upregulated and acting as an oncogene in ESCC. ..
  7. You W, Wang Y, Zheng J. Plasma miR-127 and miR-218 Might Serve as Potential Biomarkers for Cervical Cancer. Reprod Sci. 2015;22:1037-41 pubmed publisher
    ..00%, and specificity of 82.35%. In conclusion, we identified the predictive power of 3 plasma miRNAs for cervical cancer, and consequence can be concluded that plasma miR-127 and miR-205 are promising tumor markers for cervical cancer. ..
  8. Cuk K, Zucknick M, Madhavan D, Schott S, Golatta M, Heil J, et al. Plasma microRNA panel for minimally invasive detection of breast cancer. PLoS ONE. 2013;8:e76729 pubmed publisher
    ..81 for the detection of benign and malignant breast tumors, which further increased to 0.86 in younger women (up to 50 years of age). ..
  9. Feng R, Dong L. Knockdown of microRNA-127 reverses adriamycin resistance via cell cycle arrest and apoptosis sensitization in adriamycin-resistant human glioma cells. Int J Clin Exp Pathol. 2015;8:6107-16 pubmed
    ..Our data indicate that down-regulation of micorRNA-127 can trigger apoptosis and overcome drug resistance of gliomas cells. Therefore, this resistance of adriamycin in gliomas can be cancelled by silencing expression of microRNA-127. ..
  10. Fellenberg J, Sähr H, Kunz P, Zhao Z, Liu L, Tichy D, et al. Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6. Cancer Lett. 2016;371:134-41 pubmed publisher
  11. Bi L, Yang Q, Yuan J, Miao Q, Duan L, Li F, et al. MicroRNA-127-3p acts as a tumor suppressor in epithelial ovarian cancer by regulating the BAG5 gene. Oncol Rep. 2016;36:2563-2570 pubmed publisher
    ..In conclusion, miR-127-3p functions as a tumor suppressor in EOC, and its influence on EOC is directly through regulation of BAG5. ..
  12. Zhou J, Lu S, Yang S, Chen H, Shi H, Miao M, et al. MicroRNA-127 post-transcriptionally downregulates Sept7 and suppresses cell growth in hepatocellular carcinoma cells. Cell Physiol Biochem. 2014;33:1537-46 pubmed publisher
    ..Furthermore, the knockdown of Sept7 has the same effect on cell proliferation as the overexpression of miR-127 in Huh7 cells. miR-127 plays a tumor-suppressor role and can serve as a potential diagnostic biomarker for HCC. ..
  13. Chen J, Wang M, Guo M, Xie Y, Cong Y. miR-127 regulates cell proliferation and senescence by targeting BCL6. PLoS ONE. 2013;8:e80266 pubmed publisher
    ..Over-expression of miR-127 or depletion of BCL6 inhibits breast cancer cell proliferation. Our data suggest that miR-127 may function as a tumor suppressor that modulates the oncogene BCL6. ..
  14. Zhao X, Duan Z, Liu X, Wang B, Wang X, He J, et al. MicroRNA-127 is downregulated by Tudor-SN protein and contributes to metastasis and proliferation in breast cancer cell line MDA-MB-231. Anat Rec (Hoboken). 2013;296:1842-9 pubmed publisher
    ..Collectively, our results suggested a novel mechanism that Tudor-SN promoted metastasis and proliferation of breast cancer cells via downregulating the miR-127 expression. ..
  15. Wang S, Li H, Wang J, Wang D, Yao A, Li Q. Prognostic and biological significance of microRNA-127 expression in human breast cancer. Dis Markers. 2014;2014:401986 pubmed publisher
    ..Therefore, miR-127 may be a potential biomarker for predicting the survival of BC patients and might be a molecular target for treatment of human BCs. ..
  16. Tu M, Li Y, Zeng C, Deng Z, Gao S, Xiao W, et al. MicroRNA-127-5p regulates osteopontin expression and osteopontin-mediated proliferation of human chondrocytes. Sci Rep. 2016;6:25032 pubmed publisher
    ..Interestingly, miR-127-5p inhibited proliferation of chondrocytes through OPN. In conclusion, miRNA-127-5p is an important regulator of OPN in human chondrocytes and may contribute to the development of OA. ..
  17. Yu Y, Liu L, Ma R, Gong H, Xu P, Wang C. MicroRNA-127 is aberrantly downregulated and acted as a functional tumor suppressor in human pancreatic cancer. Tumour Biol. 2016;37:14249-14257 pubmed
    ..MiR-127 is downregulated and acting as a tumor suppressor in pancreatic carcinoma. The functional regulation of miR-127 in pancreatic carcinoma is very likely through the inverse correlation of its downstream target gene of BAG5. ..