Gene Symbol: MIR125B1
Description: microRNA 125b-1
Alias: MIRN125B1
Species: human
Products:     MIR125B1

Top Publications

  1. Puissegur M, Eichner R, Quelen C, Coyaud E, Mari B, Lebrigand K, et al. B-cell regulator of immunoglobulin heavy-chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells. Leukemia. 2012;26:2224-32 pubmed publisher
    ..In summary, miR-125b can act as an oncogene in B-ALL by targeting ARID3a and mediating its repression, thus leading to a blockage in differentiation, increased proliferation and inhibition of apoptosis. ..
  2. Muramatsu F, Kidoya H, Naito H, Sakimoto S, Takakura N. microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin. Oncogene. 2013;32:414-21 pubmed publisher
    ..Thus, miR-125b may be useful in cancer therapy by causing the collapse of the lumen of ECs...
  3. Kim K, Bin B, Kim J, Dong S, Park P, Choi H, et al. Novel inhibitory function of miR-125b in melanogenesis. Pigment Cell Melanoma Res. 2014;27:140-4 pubmed publisher
    ..Moreover, we observed that the reduction in miR-125b expression in pigmented cells was at least partially due to the hypermethylation of the MIR125B-1 promoter, and miR-125b expression was regulated by intracellular cAMP levels. ..
  4. Amir S, Ma A, Shi X, Xue L, Kung H, deVere White R. Oncomir miR-125b suppresses p14(ARF) to modulate p53-dependent and p53-independent apoptosis in prostate cancer. PLoS ONE. 2013;8:e61064 pubmed publisher
    ..This reinforces our belief that miR-125b has potential as a therapeutic target for the management of patients with metastatic prostate cancer. ..
  5. Xia H, He T, Liu C, Cui Y, Song P, Jin X, et al. MiR-125b expression affects the proliferation and apoptosis of human glioma cells by targeting Bmf. Cell Physiol Biochem. 2009;23:347-58 pubmed publisher
    ..BMF may play an important role in the process of miR-125b influencing cell apoptosis. ..
  6. Kim S, Ramasamy K, Bouamar H, Lin A, Jiang D, Aguiar R. MicroRNAs miR-125a and miR-125b constitutively activate the NF-?B pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20). Proc Natl Acad Sci U S A. 2012;109:7865-70 pubmed publisher
    ..Further, as miR-125b is a direct NF-?B transcriptional target, our results suggest the presence of a positive self-regulatory loop whereby termination of TNFAIP3 function by miR-125 could strengthen and prolong NF-?B activity. ..
  7. Tang F, Zhang R, He Y, Zou M, Guo L, Xi T. MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells. PLoS ONE. 2012;7:e35435 pubmed publisher
    ..In summary, our study provided new insights into the function of miR-125b during the metastasis of breat cancer cells and also suggested the role of miR-125b in pro-metastasis by targeting STARD13. ..
  8. Huang L, Luo J, Cai Q, Pan Q, Zeng H, Guo Z, et al. MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3. Int J Cancer. 2011;128:1758-69 pubmed publisher
    ..Taken together, miR-125b may act as a tumor suppressor in bladder urothelium, and downregulation of miR-125b may contribute to the tumorigenesis of bladder cancer. ..
  9. Guan Y, Yao H, Zheng Z, Qiu G, Sun K. MiR-125b targets BCL3 and suppresses ovarian cancer proliferation. Int J Cancer. 2011;128:2274-83 pubmed publisher
    ..Furthermore, expression of miR-125b suppressed the tumor formation generated by injecting OC cells in nude mice. Our results suggest that aberrantly expressed miR-125b may contribute to OC development. ..

More Information


  1. Ooi A, Sahoo D, Adorno M, Wang Y, Weissman I, Park C. MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets. Proc Natl Acad Sci U S A. 2010;107:21505-10 pubmed publisher
    ..Taken together, these data reveal that miR-125b regulates HSC survival and can promote lymphoid-fate decisions at the level of the HSC by preferentially expanding lymphoid-balanced and lymphoid-biased HSC. ..
  2. Akhavantabasi S, Sapmaz A, Tuna S, Erson Bensan A. miR-125b targets ARID3B in breast cancer cells. Cell Struct Funct. 2012;37:27-38 pubmed
    ..When ARID3B was transiently silenced, the decreased cell migration was also observed. In light of these findings, miR-125b continues to emerge as an interesting regulator of cancer related phenotypes. ..
  3. Rajaram M, Ni B, Morris J, Brooks M, Carlson T, Bakthavachalu B, et al. Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. Proc Natl Acad Sci U S A. 2011;108:17408-13 pubmed publisher
    ..tb cell wall component, TB-LM, to block TNF biosynthesis in human macrophages, thereby allowing M.tb to subvert host immunity and potentially increase its virulence. ..
  4. Liu L, Li H, Li J, Zhong H, Zhang H, Chen J, et al. miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. Biochem Biophys Res Commun. 2011;416:31-8 pubmed publisher
    ..Taken together, our findings point to an important role in the molecular etiology of osteosarcoma and suggest that miR-125b is a potential target in the treatment of osteosarcoma. ..
  5. Wang Y, Cai N, Wu X, Cao H, Xie L, Zheng P. OCT4 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells by miR-125b/BAK1 pathway. Cell Death Dis. 2013;4:e760 pubmed publisher
    ..These findings suggest an undescribed regulatory pathway in cervical cancer, by which OCT4 directly induces expression of miR-125b, which inhibits its direct target BAK1, leading to suppression of cervical cancer cell apoptosis. ..
  6. Luo X, Zhang L, Li M, Zhang W, Leng X, Zhang F, et al. The role of miR-125b in T lymphocytes in the pathogenesis of systemic lupus erythematosus. Clin Exp Rheumatol. 2013;31:263-71 pubmed
    ..These data identified this miRNA expression profile as a possible new biomarker of SLE. Moreover, the down-regulation of miR-125b mainly in T cells may contribute to the pathogenesis of SLE by regulating ETS1 and STAT3 gene expression. ..
  7. He J, Xu Q, Jing Y, Agani F, Qian X, Carpenter R, et al. Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation. EMBO Rep. 2012;13:1116-22 pubmed publisher
    ..These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR-199a and miR-125b downregulation and DNA hypermethylation. ..
  8. Malumbres R, Sarosiek K, Cubedo E, Ruiz J, Jiang X, Gascoyne R, et al. Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas. Blood. 2009;113:3754-64 pubmed publisher
    ..A 9-miRNA signature was identified that could precisely differentiate the 2 major subtypes of DLBCL. Finally, expression of some of the miRNAs in this signature is correlated with clinical outcome of uniformly treated DLBCL patients. ..
  9. Xu N, Brodin P, Wei T, Meisgen F, Eidsmo L, Nagy N, et al. MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2. J Invest Dermatol. 2011;131:1521-9 pubmed publisher
    ..Loss of miR-125b in psoriasis skin may contribute to hyperproliferation and aberrant differentiation of keratinocytes. ..
  10. Zhou M, Liu Z, Zhao Y, Ding Y, Liu H, Xi Y, et al. MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression. J Biol Chem. 2010;285:21496-507 pubmed publisher
    ..This finding has important implications in the development of targeted therapeutics for overcoming Taxol resistance in a number of different tumor histologies. ..
  11. Fan D, Tsang F, Tam A, Au S, Wong C, Wei L, et al. Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b. Hepatology. 2013;57:637-47 pubmed publisher
    ..Our study demonstrated that SUV39H1 up-regulation contributed to HCC development and metastasis. The tumor-suppressive miR-125b served as a negative regulator of SUV39H1. ..
  12. Chapiro E, Russell L, Struski S, Cave H, Radford Weiss I, Valle V, et al. A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia. Leukemia. 2010;24:1362-4 pubmed publisher
  13. Lee Y, Kim H, Chung S, Kim K, Dutta A. Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation. J Biol Chem. 2005;280:16635-41 pubmed
    ..Collectively these results reveal the importance of micro-RNA depletion strategies for directly determining micro-RNA function in vivo. ..
  14. Zhang H, Luo X, Feng D, Zhang X, Wu J, Zheng Y, et al. Upregulation of microRNA-125b contributes to leukemogenesis and increases drug resistance in pediatric acute promyelocytic leukemia. Mol Cancer. 2011;10:108 pubmed publisher
  15. Zhang Y, Yan L, Wu Q, Du Z, Chen J, Liao D, et al. miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer Res. 2011;71:3552-62 pubmed publisher
    ..Taken together, our findings point to an important role for miR-125b in the molecular etiology of invasive breast cancer, and they suggest miR-125b as a potential theranostic tool in this disease. ..
  16. Murray M, Rushworth S, Zaitseva L, Bowles K, MacEwan D. Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression. Cell Cycle. 2013;12:2144-53 pubmed publisher
    ..These mechanisms provide insight into the role of miRNA regulation of apoptosis and their promotion of MM cell proliferative mechanisms. ..
  17. Le M, Shyh Chang N, Khaw S, Chin L, Teh C, Tay J, et al. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet. 2011;7:e1002242 pubmed publisher
    ..Our results lead us to propose that miR-125b buffers and fine-tunes p53 network activity by regulating the dose of both proliferative and apoptotic regulators, with implications for tissue stem cell homeostasis and oncogenesis. ..
  18. Shiiba M, Shinozuka K, Saito K, Fushimi K, Kasamatsu A, Ogawara K, et al. MicroRNA-125b regulates proliferation and radioresistance of oral squamous cell carcinoma. Br J Cancer. 2013;108:1817-21 pubmed publisher
    ..Thus, controlling the expression or activity of miR-125b might contribute to suppressing proliferation and overcoming radioresistance in OSCC. ..
  19. Lin K, Zhang X, Feng D, Zhang H, Zeng C, Han B, et al. miR-125b, a target of CDX2, regulates cell differentiation through repression of the core binding factor in hematopoietic malignancies. J Biol Chem. 2011;286:38253-63 pubmed publisher
  20. Nakanishi H, Taccioli C, Palatini J, Fernandez Cymering C, Cui R, Kim T, et al. Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway. Oncogene. 2014;33:702-12 pubmed publisher
    ..Thus, loss of miR-125b-1 may have a key role in the pathogenesis and progression of squamous cell carcinomas of head and neck and possibly of other tumors. ..
  21. Holst L, Kaczkowski B, Glud M, Futoma Kazmierczak E, Hansen L, Gniadecki R. The microRNA molecular signature of atypic and common acquired melanocytic nevi: differential expression of miR-125b and let-7c. Exp Dermatol. 2011;20:278-80 pubmed publisher
    ..Our data suggest that miRNAs are functionally involved in the pathogenesis of nevi and possibly malignant melanoma. ..
  22. Manfé V, Biskup E, Willumsgaard A, Skov A, Palmieri D, Gasparini P, et al. cMyc/miR-125b-5p signalling determines sensitivity to bortezomib in preclinical model of cutaneous T-cell lymphomas. PLoS ONE. 2013;8:e59390 pubmed publisher
    ..Our findings describe a novel mechanism through which miR-125b-5p not only regulates tumor growth in vivo, but also increases cellular resistance to proteasome inhibitors via modulation of MAD4. ..
  23. Ahuja D, Goyal A, Ray P. Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress. RNA Biol. 2016;13:1152-1165 pubmed
    ..The antagonistic interplay between miR-125b and HuR might play an important role in fine-tuning p53 gene expression at the post-transcriptional level, and thereby regulate the cellular response to genotoxic stress. ..
  24. Huang S, Chen M, Li L, He M, Hu D, Zhang X, et al. Circulating MicroRNAs and the occurrence of acute myocardial infarction in Chinese populations. Circ Cardiovasc Genet. 2014;7:189-98 pubmed publisher
    ..The plasma levels of miR-320b and miR-125b were significantly lower in patients with AMI when compared with controls, and these miRNAs may be involved in the pathogenesis of coronary heart disease. ..
  25. He J, Jing Y, Li W, Qian X, Xu Q, Li F, et al. Roles and mechanism of miR-199a and miR-125b in tumor angiogenesis. PLoS ONE. 2013;8:e56647 pubmed publisher
    ..This study provides a rationale for new therapeutic approach to suppress tumor angiogenesis using miR-199a, miR-125b, or their mimics for ovarian cancer treatment in the future. ..
  26. Tsang F, Au V, Lu W, Shek F, Liu A, Luk J, et al. Prognostic marker microRNA-125b inhibits tumorigenic properties of hepatocellular carcinoma cells via suppressing tumorigenic molecule eIF5A2. Dig Dis Sci. 2014;59:2477-87 pubmed publisher
    ..Expression of miR-125b can reverse the tumorigenic properties of cultured HCC cells via suppressing the tumorigenic molecule eIF5A2, thus postulating restoration of miR-125b level as a way to counteract liver tumorigenesis. ..
  27. Xie X, Hu Y, Xu L, Fu Y, Tu J, Zhao H, et al. The role of miR-125b-mitochondria-caspase-3 pathway in doxorubicin resistance and therapy in human breast cancer. Tumour Biol. 2015;36:7185-94 pubmed publisher
    ..Thus, this study revealed the role of miR-125b in doxorubicin resistance and therapy, which may provide novel approaches for the treatment of breast cancer. ..
  28. Matsukawa T, Sakai T, Yonezawa T, Hiraiwa H, Hamada T, Nakashima M, et al. MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes. Arthritis Res Ther. 2013;15:R28 pubmed publisher
    ..Our results indicate that miR-125b plays an important role in regulating the expression of ADAMTS-4 in human chondrocytes and this identifies miR-125b as a novel therapeutic target in OA. ..
  29. Yuan T, Zhang H, Lin X, Yu J, Yang Q, Liang Y, et al. microRNA-125b reverses the multidrug resistance of nasopharyngeal carcinoma cells via targeting of Bcl-2. Mol Med Rep. 2017;15:2223-2228 pubmed publisher
    ..Collectively, the results of the present study highlight miR?125b as a potential therapeutic target for reversing MDR in NPC. ..
  30. Busch S, Auth E, Schöll F, Huenecke S, Koehl U, Suess B, et al. 5-lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p. J Immunol. 2015;194:1646-53 pubmed publisher
    ..Taken together, our data reveal that miR-19a-3p and miR-125b-5p target 5-LO in a cell type- and stimulus-specific manner. ..
  31. Li Y, Chao Y, Fang Y, Wang J, Wang M, Zhang H, et al. MTA1 promotes the invasion and migration of non-small cell lung cancer cells by downregulating miR-125b. J Exp Clin Cancer Res. 2013;32:33 pubmed publisher
    ..The newly identified MTA1-miR-125b axis will help further elucidate the molecular mechanism of NSCLC progression and suggest that ectopic expression of miR-125b is a potentially new therapeutic regimen against NSCLC metastasis. ..
  32. Liu B, Su F, Chen M, Li Y, Qi X, Xiao J, et al. Serum miR-21 and miR-125b as markers predicting neoadjuvant chemotherapy response and prognosis in stage II/III breast cancer. Hum Pathol. 2017;64:44-52 pubmed publisher
    ..In conclusion, ser-miR-21 and ser-miR-125b were identified as novel, noninvasive predictive markers for NCT response and prognosis in breast cancer. ..
  33. Nyholm A, Lerche C, Manfé V, Biskup E, Johansen P, Morling N, et al. miR-125b induces cellular senescence in malignant melanoma. BMC Dermatol. 2014;14:8 pubmed publisher
  34. Cai X, Lu S, Zhang Z, Gonzalez C, Damania B, Cullen B. Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc Natl Acad Sci U S A. 2005;102:5570-5 pubmed
    ..We hypothesize that these viral miRNAs play a critical role in the establishment and/or maintenance of KSHV latent infection in vivo and, hence, in KSHV-induced oncogenesis. ..
  35. Wang M, Zhu X, Sha Z, Li N, Li D, Chen L. High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients. Br J Cancer. 2015;112:874-82 pubmed publisher
    ..Kinesin-1 light chain-2 protein overexpression predicts poor survival in elderly NSCLC patients. Kinesin-1 light chain-2 acts as a proto-oncogene and a functional target of miR-125b in NSCLC cells. ..
  36. Jung D, Wen J, Oh T, Song S. Differentially expressed microRNAs in pancreatic cancer stem cells. Pancreas. 2011;40:1180-7 pubmed publisher
  37. Pogue A, Cui J, Li Y, Zhao Y, Culicchia F, Lukiw W. Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation. Neurosci Lett. 2010;476:18-22 pubmed publisher
    ..The results suggest that miRNA-125b up-regulation contributes to astrogliosis and to defects in the cell cycle that are characteristic of degenerating brain tissues. ..
  38. Zhou H, Fang J, Shang L, Zhang Z, Sang Y, Xu L, et al. MicroRNAs miR-125b and miR-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulate tumour clusters. J Pathol. 2016;240:450-460 pubmed publisher
    ..Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  39. Martínez C, Rodiño Janeiro B, Lobo B, Stanifer M, Klaus B, Granzow M, et al. miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea. Gut. 2017;66:1537-1538 pubmed publisher
    ..These molecular mechanisms include miRNAs as master regulators in controlling the expression of TJ proteins and are associated with major clinical symptoms. ..
  40. Duroux Richard I, Pers Y, Fabre S, Ammari M, Baeten D, Cartron G, et al. Circulating miRNA-125b is a potential biomarker predicting response to rituximab in rheumatoid arthritis. Mediators Inflamm. 2014;2014:342524 pubmed publisher
    ..Our results identify circulating miR-125b as a novel miRNA over expressed in RA and suggest that serum level of miR-125b is potential predictive biomarker of response to rituximab treatment. ..
  41. Thorsen J, Aamot H, Roberto R, Tjønnfjord G, Micci F, Heim S. Myelodysplastic syndrome with a t(2;11)(p21;q23-24) and translocation breakpoint close to miR-125b-1. Cancer Genet. 2012;205:528-32 pubmed publisher
    ..Here we report the detailed mapping and sequencing of the breakpoint located only 2 kilobases from miR-125b-1 in an MDS patient with a t(2;11)(p21;q23-24). ..
  42. Banzhaf Strathmann J, Benito E, May S, Arzberger T, Tahirovic S, Kretzschmar H, et al. MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease. EMBO J. 2014;33:1667-80 pubmed publisher
    ..Importantly, DUSP6 and PPP1CA are also reduced in AD brains. These data implicate miR-125b in the pathogenesis of AD by promoting pathological tau phosphorylation. ..
  43. Manca S, Magrelli A, Cialfi S, Lefort K, Ambra R, Alimandi M, et al. Oxidative stress activation of miR-125b is part of the molecular switch for Hailey-Hailey disease manifestation. Exp Dermatol. 2011;20:932-7 pubmed publisher
    ..Our data suggest that oxidative stress-mediated induction of miR-125b plays a specific role in the pathogenesis of HHD by regulating the expression of factors playing an important role in keratinocyte proliferation and differentiation. ..
  44. Chen C, Zhao Y, Yu Y, Li R, Qiao J. MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day. Sci Rep. 2016;6:25302 pubmed publisher
    ..Gain-of-function of miR-125b induced a significant decrease in the number of implantation sites. In conclusion, these data shed new light on how miR-125b triggers ER decline through the regulation of MMP26 function. ..
  45. Yamada A, Horimatsu T, Okugawa Y, Nishida N, Honjo H, Ida H, et al. Serum miR-21, miR-29a, and miR-125b Are Promising Biomarkers for the Early Detection of Colorectal Neoplasia. Clin Cancer Res. 2015;21:4234-42 pubmed publisher
  46. Lee M, Kim E, Jeon M. MicroRNAs 125a and 125b inhibit ovarian cancer cells through post-transcriptional inactivation of EIF4EBP1. Oncotarget. 2016;7:8726-42 pubmed publisher
  47. Akbari Moqadam F, Lange Turenhout E, Ariës I, Pieters R, den Boer M. MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia. Leuk Res. 2013;37:1315-21 pubmed publisher
    ..05). The concerted function of miR-125b in combination with miR-99a and/or miR-100 illustrates the complexity of vincristine-resistant pediatric ALL. ..
  48. Wang J, Luo H, Xiao Y, Wang L. miR-125b inhibits keratinocyte proliferation and promotes keratinocyte apoptosis in oral lichen planus by targeting MMP-2 expression through PI3K/Akt/mTOR pathway. Biomed Pharmacother. 2016;80:373-380 pubmed publisher
    ..Taken together, these data confirm that miR-125b might inhibit keratinocyte proliferation and promote keratinocyte apoptosis in OLP pathogenesis by targeting MMP-2 through PI3K/Akt/mTOR pathway. ..
  49. Yang Q, Wang Y, Lu X, Zhao Z, Zhu L, Chen S, et al. MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells. Oncotarget. 2015;6:3268-79 pubmed
    ..These findings suggest that up-regulation of miR-125b or targeting Sema4C could serve as novel approaches to reverse chemotherapy resistance in breast cancers. ..
  50. Tsang F, Au S, Wei L, Fan D, Lee J, Wong C, et al. Long non-coding RNA HOTTIP is frequently up-regulated in hepatocellular carcinoma and is targeted by tumour suppressive miR-125b. Liver Int. 2015;35:1597-606 pubmed publisher
    ..HOTTIP is a novel oncogenic lncRNA, which negatively regulated by miR-125b. Overexpression of HOTTIP contributes to hepatocarcinogenesis by regulating the expression of its neighbouring protein-coding genes. ..
  51. Wei M, Gan L, Yang X, Jiang X, Liu J, Chen L. [The down-regulation of miR-125b-5p and up-regulation of Smad4 expression in human umbilical vein endothelial cells treated with hydrogen peroxide]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:1088-93 pubmed
    ..Conclusion High level of H2O2 up-regulates Smad4 protein expression and inhibits miR-125b-5p expression. ..
  52. Liu Z, Smith K, Khong H, Huang J, Ahn E, Zhou M, et al. miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20. Oncotarget. 2016;7:78667-78679 pubmed publisher
    ..Since both de-differentiation and dysregulated glucose metabolism contribute to the development of T-cell leukemia, these findings provide novel insights into the understanding and treatment of T-ALL. ..
  53. Wu S, Liu F, Xie L, Peng Y, Lv X, Zhu Y, et al. miR-125b Suppresses Proliferation and Invasion by Targeting MCL1 in Gastric Cancer. Biomed Res Int. 2015;2015:365273 pubmed publisher
    ..By understanding the function and molecular mechanisms of miR-125b in gastric cancer, we may learn that miR-125b has the therapeutic potential to suppress gastric cancer progression and increase drug sensitivity to gastric cancer. ..
  54. Hruskova V, Jandová R, Vernerova L, Mann H, Pecha O, Prajzlerová K, et al. MicroRNA-125b: association with disease activity and the treatment response of patients with early rheumatoid arthritis. Arthritis Res Ther. 2016;18:124 pubmed publisher
    ..652 (95 % CI 0.510 to 0.793); p?=?0.048). The expression of miR-125b in PBMCs of treatment-naïve patients may present a novel biomarker for monitoring the treatment outcome during the early phase of RA. ..
  55. Pronina I, Loginov V, Burdennyy A, Fridman M, Senchenko V, Kazubskaya T, et al. DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. Gene. 2017;604:1-8 pubmed publisher
  56. Akman H, Selcuklu S, Donoghue M, Akhavantabasi S, Sapmaz A, Spillane C, et al. ALCAM is indirectly modulated by miR-125b in MCF7 cells. Tumour Biol. 2015;36:3511-20 pubmed publisher
  57. He H, Xu F, Huang W, Luo S, Lin Y, Zhang G, et al. miR-125a-5p expression is associated with the age of breast cancer patients. Genet Mol Res. 2015;14:17927-33 pubmed publisher
  58. Ying X, Wei K, Lin Z, Cui Y, Ding J, Chen Y, et al. MicroRNA-125b Suppresses Ovarian Cancer Progression via Suppression of the Epithelial-Mesenchymal Transition Pathway by Targeting the SET Protein. Cell Physiol Biochem. 2016;39:501-10 pubmed publisher
    ..miR-125b suppresses EOC cell migration and invasion by targeting the SET protein, and this study may provide a novel mechanism for understanding the progression of EOC. ..
  59. Takeda Y, Xu Q. Neuronal Differentiation of Human Mesenchymal Stem Cells Using Exosomes Derived from Differentiating Neuronal Cells. PLoS ONE. 2015;10:e0135111 pubmed publisher
    ..These results suggest that the delivery of miRNAs contained in PC12-derived exosomes is a possible mechanism explaining the neuronal differentiation of MSC. ..
  60. Vargas Romero P, Cialfi S, Palermo R, De Blasio C, Checquolo S, Bellavia D, et al. The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBP?. Leukemia. 2015;29:2442-5 pubmed publisher
  61. Zhou S, Zhang P, Liang P, Huang X. The expression of miR-125b regulates angiogenesis during the recovery of heat-denatured HUVECs. Burns. 2015;41:803-11 pubmed publisher
    ..Taken together our results show that the expression of miR-125b is time-dependent and miR-125b plays a regulatory role of angiogenesis during wound healing after burns. ..
  62. Zhang Z, Chen J, He Y, Zhan X, Zhao R, Huang Y, et al. miR-125b inhibits hepatitis B virus expression in vitro through targeting of the SCNN1A gene. Arch Virol. 2014;159:3335-43 pubmed publisher
    ..Using a dual luciferase reporter system, we found that SCNN1A was one of the targets of miR-125b. In this study, we found that miR-125b inhibits HBV expression in vitro by regulating SCNN1A expression. ..
  63. Davis B, Hilyard A, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008;454:56-61 pubmed publisher
  64. Chao C, Liu Y, Su S, Yeh H, Chen H, Lee P, et al. Circulating MicroRNA-125b Predicts the Presence and Progression of Uremic Vascular Calcification. Arterioscler Thromb Vasc Biol. 2017;37:1402-1414 pubmed publisher
    ..The results suggest that serum miR-125b levels are associated with VC severity and serve as a novel predictive marker for the risk of uremia-associated calcification progression. ..
  65. Chen J, Fu X, Wan Y, Wang Z, Jiang D, Shi L. miR-125b inhibitor enhance the chemosensitivity of glioblastoma stem cells to temozolomide by targeting Bak1. Tumour Biol. 2014;35:6293-302 pubmed publisher
    ..Restoring Bak1 expression recovered TMZ sensitivity on GSCs. Taken together; our data strongly support an important role for miR-125b on conferring TMZ resistance through targeting Bak1 expression. ..
  66. Maqbool R, Rashid R, Ismail R, Niaz S, Chowdri N, Hussain M. The carboxy-terminal domain of connexin 43 (CT-Cx43) modulates the expression of p53 by altering miR-125b expression in low-grade human breast cancers. Cell Oncol (Dordr). 2015;38:443-51 pubmed publisher
    ..Our data suggest a mechanism by which CT-Cx43 may regulate cell proliferation. Targeting of CT-Cx43 and/or miR-125b may be instrumental for therapeutic intervention in human breast cancer. ..
  67. Wan Y, Sun G, Zhang S, Wang Z, Shi L. MicroRNA-125b inhibitor sensitizes human primary glioblastoma cells to chemotherapeutic drug temozolomide on invasion. In Vitro Cell Dev Biol Anim. 2013;49:599-607 pubmed publisher
    ..These findings indicate that the combination of miR-125b inhibitor and TMZ treatment could effectively inhibit the glioblastoma cell invasion by inhibiting Notch1 expression. ..
  68. Djeghloul D, Kuranda K, Kuzniak I, Barbieri D, Naguibneva I, Choisy C, et al. Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation. Stem Cell Reports. 2016;6:970-984 pubmed publisher
    ..Our findings highlight the importance of heterochromatin regulation in HSC aging and B lymphopoiesis. ..
  69. Zhang F, Fan X, Bai Y, Lu J, Zheng M, Chen J, et al. miR-125b regulates procalcitonin production in monocytes by targeting Stat3. Microbes Infect. 2016;18:102-8 pubmed publisher
    ..In this study, we demonstrate that the expression of PCT is regulated by miR-125b in human monocytes. miR-125b modulates PCT expression by manipulating the amount and transcriptional activity of Stat3. ..
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    ..We also demonstrate that linc-NeD125 functions independently of the hosted microRNA, by reducing cell proliferation and activating the antiapoptotic factor BCL-2. ..
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    ..In conclusion, these results indicated that miR-125b suppressed ATC cell migration and invasion by targeting PIK3CD expression, and suggested novel potential therapeutic targets for the treatment of ATC. ..
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    ..MiR-125b-5p attenuates the secretion of MCP-1 by directly targeting inhibiting LACTB in LPS-stimulated THP-1 macrophages. ..
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    ..Our studies showing epigenetic silencing of miR-125b contributes to an invasive phenotype provide novel mechanistic insights and identify a potential target mechanism that could be manipulated for therapeutic benefit in HCC. ..
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    ..These findings, for the first time, provides evidence that the miR-125b-mediated inhibition of Stat3 is involved in the ATO-induced attenuation of metastasis in chondrosarcoma cells. ..
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    ..Evaluating the role of miRs in arterial calcification in vivo may have important therapeutic implications. ..