Gene Symbol: MIR1228
Description: microRNA 1228
Alias: MIRN1228, hsa-mir-1228
Yan B, Zhao J. miR-1228 prevents cellular apoptosis through targeting of MOAP1 protein. Apoptosis. 2012;17:717-24 pubmed publisher
..Taken together, this study provides evidences that miR-1228 plays an inhibitory role in stress-induced cellular apoptosis. miR-1228 may become a critical therapeutic target for apoptosis relevant diseases in the future. ..
Lisse T, Chun R, Rieger S, Adams J, Hewison M. Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts. J Bone Miner Res. 2013;28:1478-88 pubmed publisher
..These data show for the first time that the effects of 1,25D on human bone cells are not restricted to classical VDR-mediated transcriptional responses but also involve miRNA-directed posttranscriptional mechanisms...
Jia L, Wu J, Zhang L, Chen J, Zhong D, Xu S, et al
. Restoration of miR-1228* expression suppresses epithelial-mesenchymal transition in gastric cancer. PLoS ONE. 2013;8:e58637 pubmed publisher
..Collectively, these findings provide the first evidence that miR-1228* plays an important role in regulating gastric cancer growth and suggest that selective restoration of miR-1228* might be beneficial for gastric cancer therapy. ..
Hu J, Wang Z, Liao B, Yu L, Gao X, Lu S, et al
. Human miR-1228 as a stable endogenous control for the quantification of circulating microRNAs in cancer patients. Int J Cancer. 2014;135:1187-94 pubmed publisher
..The results explained the steady expression of miR-1228 in the blood. In conclusion, miR-1228 is a promising stable endogenous control for quantifying circulating microRNAs in cancer patients. ..
Zhang Y, Dai J, Deng H, Wan H, Liu M, Wang J, et al
. miR-1228 promotes the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop. Br J Cancer. 2015;112:365-74 pubmed publisher
..p53 downregulation in turn leads to an increase in miR-1228 expression, thereby forming a positive feedback loop that contributes to cancerogenesis in HCC. ..
Lin L, Liu D, Liang H, Xue L, Su C, Liu M. MiR-1228 promotes breast cancer cell growth and metastasis through targeting SCAI protein. Int J Clin Exp Pathol. 2015;8:6646-55 pubmed
..Taken together, this study provides evidences that miR-1228 serves as an oncogene to promote breast cancer proliferation, invasion and migration, which may become a critical therapeutic target for breast cancer treatment. ..
Li X, Ding Z, Zhang C, Zhang X, Meng Q, Wu S, et al
. MicroRNA-1228(*) inhibit apoptosis in A549 cells exposed to fine particulate matter. Environ Sci Pollut Res Int. 2016;23:10103-13 pubmed publisher
..5-induced A549 apoptosis is initiated by mitochondrial dysfunction and miR-1228(*) could protect A549 cells against apoptosis. The involved pathways and target genes might be used for future mechanistic studies. ..
Jia L, Chen J, Xie C, Shao L, Xu Z, Zhang L. microRNA-1228? impairs the pro-angiogenic activity of gastric cancer cells by targeting macrophage migration inhibitory factor. Life Sci. 2017;180:9-16 pubmed publisher
..This work suggests miR-1228? as a potential target for anti-angiogenic therapy against gastric cancer. ..