MIR122

Summary

Gene Symbol: MIR122
Description: microRNA 122
Alias: MIR122A, MIRN122, MIRN122A, hsa-mir-122, miRNA122, miRNA122A
Species: human
Products:     MIR122

Top Publications

  1. Kutay H, Bai S, Datta J, Motiwala T, Pogribny I, Frankel W, et al. Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J Cell Biochem. 2006;99:671-8 pubmed
    ..013) reduced in 10 out of 20 tumors compared to the pair-matched control tissues. These findings suggest that the downregulation of miR-122 is associated with hepatocarcinogenesis and could be a potential biomarker for liver cancers. ..
  2. Sarasin Filipowicz M, Krol J, Markiewicz I, Heim M, Filipowicz W. Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy. Nat Med. 2009;15:31-3 pubmed publisher
    ..These data have implications for the prospect of targeting miRNAs for CHC therapy. ..
  3. Hu J, Xu Y, Hao J, Wang S, Li C, Meng S. MiR-122 in hepatic function and liver diseases. Protein Cell. 2012;3:364-71 pubmed publisher
  4. Zhang C, Huys A, Thibault P, Wilson J. Requirements for human Dicer and TRBP in microRNA-122 regulation of HCV translation and RNA abundance. Virology. 2012;433:479-88 pubmed publisher
    ..Thus, canonical miRNA processing and strand selection is essential for the activity of miR-122 on HCV translation and RNA accumulation. ..
  5. Liu A, Xu Z, Shek F, Wong K, Lee N, Poon R, et al. miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma. PLoS ONE. 2014;9:e86872 pubmed publisher
    ..The present study demonstrated the regulatory role of miR-122 on PKM2 in HCC, having an implication of therapeutic intervention targeting cancer metabolic pathways. ..
  6. Xu J, Zhu X, Wu L, Yang R, Yang Z, Wang Q, et al. MicroRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/?-catenin pathway. Liver Int. 2012;32:752-60 pubmed publisher
    ..05). MiR-122 expression is down-regulated in human HCC. Over-expression of miR-122 inhibits HCC cell growth and promotes the cell apoptosis by affecting Wnt/?-catenin-TCF signalling pathway. ..
  7. Jopling C. Regulation of hepatitis C virus by microRNA-122. Biochem Soc Trans. 2008;36:1220-3 pubmed publisher
    ..The binding site requirements for miR-122 to positively regulate HCV replication provide an insight into this unusual mode of miRNA action. ..
  8. Waidmann O, Köberle V, Brunner F, Zeuzem S, Piiper A, Kronenberger B. Serum microRNA-122 predicts survival in patients with liver cirrhosis. PLoS ONE. 2012;7:e45652 pubmed publisher
    ..Serum miR-122 is a new independent marker for prediction of survival of patients with liver cirrhosis. ..
  9. Li J, Ghazwani M, Zhang Y, Lu J, Li J, Fan J, et al. miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression. J Hepatol. 2013;58:522-8 pubmed publisher
    ..Our study suggests that miR-122 may play an important role in negatively regulating collagen production in HSCs and that targeted expression of miR-122 in HSCs may represent a new strategy for the treatment of liver fibrosis. ..
  10. Jangra R, Yi M, Lemon S. Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122. J Virol. 2010;84:6615-25 pubmed publisher
    ..miR-122 is thus likely to act at an additional step in the virus life cycle. ..

Detail Information

Publications80

  1. Kutay H, Bai S, Datta J, Motiwala T, Pogribny I, Frankel W, et al. Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J Cell Biochem. 2006;99:671-8 pubmed
    ..013) reduced in 10 out of 20 tumors compared to the pair-matched control tissues. These findings suggest that the downregulation of miR-122 is associated with hepatocarcinogenesis and could be a potential biomarker for liver cancers. ..
  2. Sarasin Filipowicz M, Krol J, Markiewicz I, Heim M, Filipowicz W. Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy. Nat Med. 2009;15:31-3 pubmed publisher
    ..These data have implications for the prospect of targeting miRNAs for CHC therapy. ..
  3. Hu J, Xu Y, Hao J, Wang S, Li C, Meng S. MiR-122 in hepatic function and liver diseases. Protein Cell. 2012;3:364-71 pubmed publisher
  4. Zhang C, Huys A, Thibault P, Wilson J. Requirements for human Dicer and TRBP in microRNA-122 regulation of HCV translation and RNA abundance. Virology. 2012;433:479-88 pubmed publisher
    ..Thus, canonical miRNA processing and strand selection is essential for the activity of miR-122 on HCV translation and RNA accumulation. ..
  5. Liu A, Xu Z, Shek F, Wong K, Lee N, Poon R, et al. miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma. PLoS ONE. 2014;9:e86872 pubmed publisher
    ..The present study demonstrated the regulatory role of miR-122 on PKM2 in HCC, having an implication of therapeutic intervention targeting cancer metabolic pathways. ..
  6. Xu J, Zhu X, Wu L, Yang R, Yang Z, Wang Q, et al. MicroRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/?-catenin pathway. Liver Int. 2012;32:752-60 pubmed publisher
    ..05). MiR-122 expression is down-regulated in human HCC. Over-expression of miR-122 inhibits HCC cell growth and promotes the cell apoptosis by affecting Wnt/?-catenin-TCF signalling pathway. ..
  7. Jopling C. Regulation of hepatitis C virus by microRNA-122. Biochem Soc Trans. 2008;36:1220-3 pubmed publisher
    ..The binding site requirements for miR-122 to positively regulate HCV replication provide an insight into this unusual mode of miRNA action. ..
  8. Waidmann O, Köberle V, Brunner F, Zeuzem S, Piiper A, Kronenberger B. Serum microRNA-122 predicts survival in patients with liver cirrhosis. PLoS ONE. 2012;7:e45652 pubmed publisher
    ..Serum miR-122 is a new independent marker for prediction of survival of patients with liver cirrhosis. ..
  9. Li J, Ghazwani M, Zhang Y, Lu J, Li J, Fan J, et al. miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression. J Hepatol. 2013;58:522-8 pubmed publisher
    ..Our study suggests that miR-122 may play an important role in negatively regulating collagen production in HSCs and that targeted expression of miR-122 in HSCs may represent a new strategy for the treatment of liver fibrosis. ..
  10. Jangra R, Yi M, Lemon S. Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122. J Virol. 2010;84:6615-25 pubmed publisher
    ..miR-122 is thus likely to act at an additional step in the virus life cycle. ..
  11. Doddapaneni R, Chawla Y, Das A, Kalra J, Ghosh S, Chakraborti A. Overexpression of microRNA-122 enhances in vitro hepatic differentiation of fetal liver-derived stem/progenitor cells. J Cell Biochem. 2013;114:1575-83 pubmed publisher
    ..Thus, the study delineated the role of hepato-specific miR-122 in differentiation of fetal liver stem/progenitor cells into hepatocyte-like cells which could be used as a therapeutic target molecule to generate abundant hepatocytes. ..
  12. Ma L, Liu J, Shen J, Liu L, Wu J, Li W, et al. Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells. Cancer Biol Ther. 2010;9:554-61 pubmed
    ..We generated a recombinant adenoviral vector expressing miR-122 (Ad-miR122). The miR-122 expression was measured by quantitative Real-Time PCR (qRT-PCR)...
  13. Li C, Wang Y, Wang S, Wu B, Hao J, Fan H, et al. Hepatitis B virus mRNA-mediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion. J Virol. 2013;87:2193-205 pubmed publisher
    ..Our work underscores the reciprocal interplay of host miRNA sequestration and depletion by viral mRNAs, which may contribute to chronic-infection-related cancer. ..
  14. D Ambrogio A, Gu W, Udagawa T, Mello C, Richter J. Specific miRNA stabilization by Gld2-catalyzed monoadenylation. Cell Rep. 2012;2:1537-45 pubmed publisher
    ..These results establish a mechanism of miRNA stability and resulting posttranscriptional gene regulation. ..
  15. Xu J, Wu C, Che X, Wang L, Yu D, Zhang T, et al. Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis. Mol Carcinog. 2011;50:136-42 pubmed publisher
    ..Our results indicate that serum miR-21, miR-122 and miR-223 are elevated in patients with HCC or chronic hepatitis and these miRNAs have strong potential to serve as novel biomarkers for liver injury but not specifically for HCC. ..
  16. Norman K, Sarnow P. Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms. J Virol. 2010;84:666-70 pubmed publisher
    ..Loss of HCV RNA could not be restored by isoprenoid intermediate metabolites. Overall, these findings suggest that miR-122 modulates viral RNA abundance independently of its effect on isoprenoid metabolism. ..
  17. Coulouarn C, Factor V, Andersen J, Durkin M, Thorgeirsson S. Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene. 2009;28:3526-36 pubmed publisher
    ..From a clinical point of view, our study emphasizes miR-122 as a diagnostic and prognostic marker for HCC progression. ..
  18. Shimakami T, Yamane D, Jangra R, Kempf B, Spaniel C, Barton D, et al. Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex. Proc Natl Acad Sci U S A. 2012;109:941-6 pubmed publisher
    ..miR-122 thus acts in an unconventional fashion to stabilize HCV RNA and slow its decay, expanding the repertoire of mechanisms by which miRNAs modulate gene expression. ..
  19. Tsai W, Hsu P, Lai T, Chau G, Lin C, Chen C, et al. MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. Hepatology. 2009;49:1571-82 pubmed publisher
    ..Using the concomitant down-regulation of its targets, including ADAM17, a rational therapeutic strategy based on miR-122 may prove to be beneficial for patients with hepatocellular carcinoma. ..
  20. Wang S, Qiu L, Yan X, Jin W, Wang Y, Chen L, et al. Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity. Hepatology. 2012;55:730-41 pubmed publisher
    ..Our work shows that miR-122 down-regulation induced by HBV infection can impact HBV replication and possibly contribute to viral persistence and carcinogenesis. ..
  21. Yoshikawa T, Takata A, Otsuka M, Kishikawa T, Kojima K, Yoshida H, et al. Silencing of microRNA-122 enhances interferon-? signaling in the liver through regulating SOCS3 promoter methylation. Sci Rep. 2012;2:637 pubmed publisher
    ..Overexpression of microRNA-122 (miR122) significantly suppressed ISRE activity...
  22. Li A, Song W, Qian J, Li Y, He J, Zhang Q, et al. MiR-122 modulates type I interferon expression through blocking suppressor of cytokine signaling 1. Int J Biochem Cell Biol. 2013;45:858-65 pubmed publisher
    ..Mutations in the nt359-nt375 region abandoned the impact of miR-122 on SOCS1-EGFP expression. Taken together, SOCS1 is a target of miR-122. MiR-122 can regulate the type I IFN expression through modulating the SOCS1 expression. ..
  23. Song K, Han C, Zhang J, Lu D, Dash S, Feitelson M, et al. Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells. Hepatology. 2013;58:1681-92 pubmed publisher
  24. Fornari F, Gramantieri L, Giovannini C, Veronese A, Ferracin M, Sabbioni S, et al. MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res. 2009;69:5761-7 pubmed publisher
    ..Our findings establish a basis toward the development of combined chemo- and miRNA-based therapy for HCC treatment. ..
  25. Li Y, Masaki T, Yamane D, McGivern D, Lemon S. Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication. Proc Natl Acad Sci U S A. 2013;110:1881-6 pubmed publisher
    ..Nevertheless, Xrn1 knockdown does not rescue replication of a viral mutant defective in miR-122 binding, indicating that miR-122 has additional yet uncharacterized function(s) in the viral life cycle. ..
  26. Marquez R, Bandyopadhyay S, Wendlandt E, Keck K, Hoffer B, Icardi M, et al. Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans. Lab Invest. 2010;90:1727-36 pubmed publisher
    ..We found that miR-21 enhanced TGF-? signaling, further supporting a relationship between miR-21 and fibrosis. We suggest a model in which miR-21 targeting of SMAD7 could increase TGF-? signaling, leading to increased fibrogenesis. ..
  27. Boutz D, Collins P, Suresh U, Lu M, Ramírez C, Fernandez Hernando C, et al. Two-tiered approach identifies a network of cancer and liver disease-related genes regulated by miR-122. J Biol Chem. 2011;286:18066-78 pubmed publisher
    ..Additional analyses, including examination of consensus binding motifs for both miR-122 and target sequences, provide further insight into miR-122 function. ..
  28. Burns D, D Ambrogio A, Nottrott S, Richter J. CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation. Nature. 2011;473:105-8 pubmed publisher
    ..Thus, translational regulation of p53 mRNA and cellular senescence is coordinated by Gld2/miR-122/CPEB/Gld4. ..
  29. Yang F, Zhang L, Wang F, Wang Y, Huo X, Yin Y, et al. Modulation of the unfolded protein response is the core of microRNA-122-involved sensitivity to chemotherapy in hepatocellular carcinoma. Neoplasia. 2011;13:590-600 pubmed
    ..We identified a new HCC therapeutic target and proclaimed the potential risk of the therapeutic use of miR-122 silencing. ..
  30. Köberle V, Kronenberger B, Pleli T, Trojan J, Imelmann E, Peveling Oberhag J, et al. Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma. Eur J Cancer. 2013;49:3442-9 pubmed publisher
    ..Our data indicate that serum miR-1 is a new independent parameter of OS in HCC patients and may therefore improve the predictive value of classical HCC staging scores. ..
  31. Burchard J, Zhang C, Liu A, Poon R, Lee N, Wong K, et al. microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma. Mol Syst Biol. 2010;6:402 pubmed publisher
    ..In conclusion, miR-122 regulates mitochondrial metabolism and its loss may be detrimental to sustaining critical liver function and contribute to morbidity and mortality of liver cancer patients. ..
  32. Morita K, Taketomi A, Shirabe K, Umeda K, Kayashima H, Ninomiya M, et al. Clinical significance and potential of hepatic microRNA-122 expression in hepatitis C. Liver Int. 2011;31:474-84 pubmed publisher
    ..Therefore, miR-122, by itself, is not a critical molecular target for HCV therapy. MiR-122 expression is inversely correlated with both functional and histopathological liver damage. ..
  33. Henke J, Goergen D, Zheng J, Song Y, Schüttler C, Fehr C, et al. microRNA-122 stimulates translation of hepatitis C virus RNA. EMBO J. 2008;27:3300-10 pubmed publisher
    ..miR-122 stimulates HCV translation by enhancing the association of ribosomes with the viral RNA at an early initiation stage. In conclusion, the liver-specific miR-122 may contribute to HCV liver tropism at the level of translation. ..
  34. Shan Y, Zheng J, Lambrecht R, Bonkovsky H. Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes. Gastroenterology. 2007;133:1166-74 pubmed
    ..Down-regulation of miR-122 and up-regulation of HO-1 may be new strategies for anti-HCV intervention and cytoprotection. ..
  35. Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, Liu C, et al. Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res. 2007;67:6092-9 pubmed
    ..These results indicate that cyclin G1 is a target of miR-122a and expand our knowledge of the molecular alterations involved in HCC pathogenesis and of the role of miRNAs in human cancer. ..
  36. Jung C, Iyengar S, Blahnik K, Ajuha T, Jiang J, Farnham P, et al. Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation. PLoS ONE. 2011;6:e27740 pubmed publisher
  37. Chen Y, Shen A, Rider P, Yu Y, Wu K, Mu Y, et al. A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication. FASEB J. 2011;25:4511-21 pubmed publisher
  38. Chang J, Guo J, Jiang D, Guo H, Taylor J, Block T. Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells. J Virol. 2008;82:8215-23 pubmed publisher
    ..Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells. ..
  39. Wilson J, Zhang C, Huys A, Richardson C. Human Ago2 is required for efficient microRNA 122 regulation of hepatitis C virus RNA accumulation and translation. J Virol. 2011;85:2342-50 pubmed publisher
    ..These data support a model in which miR-122 functions within an Ago2-containing protein complex to augment both HCV RNA accumulation and translation. ..
  40. Lin C, Gong H, Tseng H, Wang W, Wu J. miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. 2008;375:315-20 pubmed publisher
    ..Thus, Bcl-w is a direct target of miR-122 that functions as an endogenous apoptosis regulator in these HCC-derived cell lines. ..
  41. Iliopoulos D, Drosatos K, Hiyama Y, Goldberg I, Zannis V. MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism. J Lipid Res. 2010;51:1513-23 pubmed publisher
  42. John K, Hadem J, Krech T, Wahl K, Manns M, Dooley S, et al. MicroRNAs play a role in spontaneous recovery from acute liver failure. Hepatology. 2014;60:1346-55 pubmed publisher
    ..Prospective studies will show whether serological detection of those miRNAs might be of prognostic value to predict ALF outcome. ..
  43. Beltrami C, Besnier M, Shantikumar S, Shearn A, Rajakaruna C, Laftah A, et al. Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. Mol Ther. 2017;25:679-693 pubmed publisher
    ..Collectively, our data support the concept that PF exosomes orchestrate vascular repair via miRNA transfer. ..
  44. Nasheri N, Singaravelu R, Goodmurphy M, Lyn R, Pezacki J. Competing roles of microRNA-122 recognition elements in hepatitis C virus RNA. Virology. 2011;410:336-44 pubmed publisher
    ..These data have important implications in elucidating the mechanism of interaction between microRNA-122 and HCV RNA. ..
  45. Roderburg C, Benz F, Vargas Cardenas D, Koch A, Janssen J, Vucur M, et al. Elevated miR-122 serum levels are an independent marker of liver injury in inflammatory diseases. Liver Int. 2015;35:1172-84 pubmed publisher
    ..In mice and humans, miR-122 levels represent an independent and potent marker of ongoing liver injury and hepatic cell death regardless of the underlying disease. ..
  46. Wang R, Hong J, Cao Y, Shi J, Gu W, Ning G, et al. Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults. Eur J Endocrinol. 2015;172:291-300 pubmed publisher
    ..007, P=0.028). Elevated circulating miR-122 is positively associated with obesity and insulin resistance in young adults. These findings provide a better understanding regarding the role of miRNAs in adiposity and insulin sensitivity. ..
  47. Jiang Y, Wang H, Li Y, Guo S, Zhang L, Cai J, et al. Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases. Sci Rep. 2014;4:5026 pubmed publisher
    ..Integrating specific pattern of miRNA levels with NT-pro-BNP and/or cardiac troponin may improve the diagnosis of cardiovascular diseases. ..
  48. Rivkin M, Simerzin A, Zorde Khvalevsky E, Chai C, Yuval J, Rosenberg N, et al. Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-Derived Erythropoietin and Anemia. Gastroenterology. 2016;151:999-1010.e3 pubmed publisher
    ..We investigated whether microRNA 122 (MIR122), which is generated in the liver and is secreted into the blood, is involved in the development of anemia ..
  49. Shifeng H, Danni W, Pu C, Ping Y, Ju C, Liping Z. Circulating liver-specific miR-122 as a novel potential biomarker for diagnosis of cholestatic liver injury. PLoS ONE. 2013;8:e73133 pubmed publisher
    ..Collectively, these data suggest that serum miR-122 has strong potential as a novel, specific and noninvasive biomarker for diagnosis of cholestasis-induced liver injury. ..
  50. Wei S, Zhang M, Yu Y, Xue H, Lan X, Liu S, et al. HNF-4? regulated miR-122 contributes to development of gluconeogenesis and lipid metabolism disorders in Type 2 diabetic mice and in palmitate-treated HepG2 cells. Eur J Pharmacol. 2016;791:254-263 pubmed publisher
    ..The results indicate that HNF-4? regulated miR-122 contributes to development of the gluconeogenic and lipid metabolism alterations observed in Type 2 diabetic mice and in palmitate-treated HepG2 cells. ..
  51. Demerdash H, Hussien H, Hassouna E, Arida E. Detection of MicroRNA in Hepatic Cirrhosis and Hepatocellular Carcinoma in Hepatitis C Genotype-4 in Egyptian Patients. Biomed Res Int. 2017;2017:1806069 pubmed publisher
    ..Moreover, miR-21 can be used as a potential biomarker, for early detection of HCC combined with VEGF and α-FP. ..
  52. Li B, Lu Y, Yu L, Han X, Wang H, Mao J, et al. miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-?B/COX-2 activation. Chem Biol Interact. 2017;277:33-42 pubmed publisher
    ..MiR-221/222 might represent the potential target of breast cancer therapy. ..
  53. Chen Y, Wang C, Liu Y, Tang L, Zheng M, Xu C, et al. miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn's disease. Biochem Biophys Res Commun. 2013;438:133-9 pubmed publisher
    ..Taken together, these results indicate that miR-122 and its target gene NOD2 may play an important role in the injury of intestinal epithelial cells induced by LPS. ..
  54. Wu X, Wu S, Tong L, Luan T, Lin L, Lu S, et al. miR-122 affects the viability and apoptosis of hepatocellular carcinoma cells. Scand J Gastroenterol. 2009;44:1332-9 pubmed publisher
    ..The absence of miR-122 expression in HepG2 cells was due to the loss of the miR-122 coding sequence in chromosome 18. These results imply that aberrant expression of miR-122 may contribute to hepatocarcinogenesis. ..
  55. Fukuhara T, Kambara H, Shiokawa M, Ono C, Katoh H, Morita E, et al. Expression of microRNA miR-122 facilitates an efficient replication in nonhepatic cells upon infection with hepatitis C virus. J Virol. 2012;86:7918-33 pubmed publisher
    ..In conclusion, although miR-122 facilitates efficient viral replication in nonhepatic cells, factors other than miR-122, which are most likely specific to hepatocytes, are required for HCV assembly. ..
  56. Iino I, Kikuchi H, Miyazaki S, Hiramatsu Y, Ohta M, Kamiya K, et al. Effect of miR-122 and its target gene cationic amino acid transporter 1 on colorectal liver metastasis. Cancer Sci. 2013;104:624-30 pubmed publisher
    ..Expression of CAT1 in the primary CRC has the potential to be a novel biomarker to predict the risk of postoperative liver metastasis of CRC patients. ..
  57. Falcon Perez J, Royo F. Circulating RNA: looking at the liver through a frosted glass. Biomarkers. 2015;20:339-54 pubmed publisher
    ..We highlight those circulating RNAs useful to diagnostic, and discuss the transport mechanisms. Several studies have proven that circulating RNAs are useful to establish a diagnostic and a prognosis of liver diseases. ..
  58. Diao S, Zhang J, Wang H, He M, Lin M, Chen Y, et al. Proteomic identification of microRNA-122a target proteins in hepatocellular carcinoma. Proteomics. 2010;10:3723-31 pubmed publisher
    ..Luciferase reporter assay confirmed the regulation of miR-122a on 5'-UTR of PRDXII. In conclusion, PRDXII was identified to be the new target of miR-122a. ..
  59. Yu Y, Scheel T, Luna J, Chung H, Nishiuchi E, Scull M, et al. miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence. PLoS Pathog. 2017;13:e1006694 pubmed publisher
    ..We propose that hepaciviruses may use this mechanism to guarantee liver tropism and exploit the tolerogenic liver environment to avoid clearance and promote chronicity. ..
  60. Wang B, Wang H, Yang Z. MiR-122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R. PLoS ONE. 2012;7:e47053 pubmed publisher
    ..Given these, miR-122 may serve as a novel therapeutic or diagnostic/prognostic-target for treating BC. ..
  61. Kumar S, Batra A, Kanthaje S, Ghosh S, Chakraborti A. Crosstalk between microRNA-122 and FOX family genes in HepG2 cells. Exp Biol Med (Maywood). 2017;242:436-440 pubmed publisher
    ..005) and that of FOXO4 was upregulated (p?<?0.005). Thus, the finding indicates deregulation of these FOX genes as a result of miR-122 augmentation might be involved in the modulation of apoptosis. ..
  62. Wilson J, Sagan S. Hepatitis C virus and human miR-122: insights from the bench to the clinic. Curr Opin Virol. 2014;7:11-8 pubmed publisher
    ..We will discuss what has been learned about this important interaction to date, provide insights into how miR-122 is able to modulate HCV RNA accumulation, and how miR-122 might be exploited for antiviral intervention. ..
  63. Wang G, Zhao Y, Zheng Y. MiR-122/Wnt/?-catenin regulatory circuitry sustains glioma progression. Tumour Biol. 2014;35:8565-72 pubmed publisher
    ..Taken together, we revealed that there is a miR-122/Wnt/?-catenin regulatory circuitry existing in glioma cells that contributes to glioma progression. ..
  64. Wei S, Zhang M, Yu Y, Lan X, Yao F, Yan X, et al. Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway. PLoS ONE. 2016;11:e0152097 pubmed publisher
    ..or treatment of PA-incubated HepG2 cells for 24 h with BBR decreased expression of HNF-4α and the microRNA miR122, the key gluconeogenesis enzymes Phosphoenolpyruvate carboxykinase (PEPCK) and Glucose-6-phosphatase (G6Pase) and ..
  65. McCrae J, Sharkey N, Webb D, Vliegenthart A, Dear J. Ethanol consumption produces a small increase in circulating miR-122 in healthy individuals. Clin Toxicol (Phila). 2016;54:53-5 pubmed publisher
    ..As increases with acetaminophen toxicity are 100- to 10 000-fold, moderate ethanol intoxication is unlikely to confound the use of this biomarker of hepatotoxicity. ..
  66. Simionescu N, Niculescu L, Carnuta M, Sanda G, Stancu C, Popescu A, et al. Hyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages. PLoS ONE. 2016;11:e0161201 pubmed publisher
  67. Zhang Y, Sturgis E, Sun Y, Sun C, Wei Q, Huang Z, et al. A functional variant at miRNA-122 binding site in IL-1α 3' UTR predicts risk and HPV-positive tumours of oropharyngeal cancer. Eur J Cancer. 2015;51:1415-23 pubmed publisher
    ..These results suggest that IL-1α 3' UTR rs3783553 polymorphism may be functional and influence susceptibility to HPV16-associated OSCC, particularly for SCCOP. Validation of our findings is warranted. ..
  68. Fong M, Zhou W, Liu L, Alontaga A, Chandra M, Ashby J, et al. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol. 2015;17:183-94 pubmed publisher
    ..These results demonstrate that, by modifying glucose utilization by recipient premetastatic niche cells, cancer-derived extracellular miR-122 is able to reprogram systemic energy metabolism to facilitate disease progression. ..
  69. Ono C, Fukuhara T, Motooka D, Nakamura S, Okuzaki D, Yamamoto S, et al. Characterization of miR-122-independent propagation of HCV. PLoS Pathog. 2017;13:e1006374 pubmed publisher
    ..These results suggest that the emergence of HCV mutants that can propagate in non-hepatic cells in an miR-122-independent manner may participate in the induction of extrahepatic manifestations in chronic hepatitis C patients. ..
  70. Duan A, Ning L, Li C, Hou Y, Yang N, Sun L, et al. A novel strategy to inhibit the reproduction and translation of hepatitis C virus. Sci China Life Sci. 2013;56:293-7 pubmed publisher
    ..This study presents a new method to inhibit HCV that may hold great potential for HCV treatment in the future. ..
  71. Choe J, Cho H, Lee H, Kim Y. microRNA/Argonaute 2 regulates nonsense-mediated messenger RNA decay. EMBO Rep. 2010;11:380-6 pubmed publisher
    ..The regulation of NMD by miRNAs will shed light on a new post-transcriptional regulation mechanism of gene expression in mammalian cells. ..
  72. Guo Z, Wu R, Gong J, Zhu W, Li Y, Wang Z, et al. Altered microRNA expression in inflamed and non-inflamed terminal ileal mucosa of adult patients with active Crohn's disease. J Gastroenterol Hepatol. 2015;30:109-16 pubmed publisher
    ..Both inflamed and non-inflamed terminal ileal mucosa in adult patients with active CD have their distinct miRNA expression patterns compared with healthy controls. Dysregulated miRNAs may be responsible for pathogenesis of CD. ..
  73. Naderi M, Pazouki A, Arefian E, Hashemi S, Jamshidi Adegani F, Gholamalamdari O, et al. Two Triacylglycerol Pathway Genes, CTDNEP1 and LPIN1, are Down-Regulated by hsa-miR-122-5p in Hepatocytes. Arch Iran Med. 2017;20:165-171 pubmed publisher
    ..Our findings suggest that up-regulation of miR-122 can trigger the compensatory response of LPIN1 and CTDNEP1 in hepatosteatosis. ..
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    ..Our results suggest an important role of the miR-122/Dicer/miR-200s/EMT pathway in ccRCC metastasis. Furthermore, miR-122 may serve as a biomarker for discriminating ccRCC with metastatic potential. ..
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    ..NAFLD has a distinguishing circulating miRNA profile associated with a global dysmetabolic disease state and cardiovascular risk. ..