MIF

Summary

Gene Symbol: MIF
Description: macrophage migration inhibitory factor
Alias: GIF, GLIF, MMIF, macrophage migration inhibitory factor, L-dopachrome isomerase, L-dopachrome tautomerase, macrophage migration inhibitory factor (glycosylation-inhibiting factor), phenylpyruvate tautomerase
Species: human
Products:     MIF

Top Publications

  1. Weber C, Kraemer S, Drechsler M, Lue H, Koenen R, Kapurniotu A, et al. Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment. Proc Natl Acad Sci U S A. 2008;105:16278-83 pubmed publisher
    We have recently identified the archaic cytokine macrophage migration inhibitory factor (MIF) as a non-canonical ligand of the CXC chemokine receptors CXCR2 and CXCR4 in inflammatory and atherogenic cell recruitment...
  2. Flieger O, Engling A, Bucala R, Lue H, Nickel W, Bernhagen J. Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter. FEBS Lett. 2003;551:78-86 pubmed
    The cytokine macrophage migration inhibitory factor (MIF) is inducibly secreted by immune cells and certain other cell types to critically participate in the regulation of the host immune response...
  3. Kim H, Lee S, Kim H, Kong M, Kim Y, Kang S, et al. Elevated levels of macrophage migration inhibitory factor in women with metabolic syndrome. Horm Metab Res. 2011;43:642-5 pubmed publisher
    ..b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine produced both by innate immune cells and by adipocytes, and it ..
  4. Assunção Miranda I, Amaral F, Bozza F, Fagundes C, Sousa L, Souza D, et al. Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection. FASEB J. 2010;24:218-28 pubmed publisher
    ..Here we studied the involvement of macrophage migration inhibitory factor (MIF) in dengue virus (DENV) infection and its pathogenesis...
  5. Nalbantoglu S, Tabel Y, Mir S, Berdeli A. Lack of association between macrophage migration inhibitory factor gene promoter (-173 G/C) polymorphism and childhood Henoch-Schönlein purpura in Turkish patients. Cytokine. 2013;62:160-4 pubmed publisher
    ..b>Macrophage migration inhibitory factor (MIF) is a immunoregulatory proinflammatory cytokine, and a major mediator at the inflammatory ..
  6. Sanchez E, Gomez L, Lopez Nevot M, Gonzalez Gay M, Sabio J, Ortego Centeno N, et al. Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus. Genes Immun. 2006;7:433-6 pubmed
    The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus...
  7. Awandare G, Ouma C, Keller C, Were T, Otieno R, Ouma Y, et al. A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria. Genes Immun. 2006;7:568-75 pubmed
    b>Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that regulates innate and adaptive immune responses to bacterial and parasitic infections...
  8. Lugrin J, Ding X, Le Roy D, Chanson A, Sweep F, Calandra T, et al. Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation. Biochim Biophys Acta. 2009;1793:1749-58 pubmed publisher
    The cytokine macrophage migration inhibitory factor plays a central role in inflammation, cell proliferation and tumorigenesis...
  9. Liao B, Zhong B, Li Z, Tian X, Li Y, Li B. Macrophage migration inhibitory factor contributes angiogenesis by up-regulating IL-8 and correlates with poor prognosis of patients with primary nasopharyngeal carcinoma. J Surg Oncol. 2010;102:844-51 pubmed publisher
    We aim at the association of macrophage migration inhibitory factor (MIF) with neovascularization and survival of nasopharyngeal carcinoma (NPC), and determine whether MIF is a valuable prognostic predictor for NPC patients...

More Information

Publications134 found, 100 shown here

  1. Griga T, Wilkens C, Wirkus N, Epplen J, Schmiegel W, Klein W. A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses. Hepatogastroenterology. 2007;54:784-6 pubmed
    b>Macrophage migration inhibitory factor (MIF) is an important cytokine involved in the regulation of the innate immune system in IBD...
  2. Liu L, Ji C, Chen J, Li Y, Fu X, Xie Y, et al. A global genomic view of MIF knockdown-mediated cell cycle arrest. Cell Cycle. 2008;7:1678-92 pubmed
    Macrophage immigration inhibitory factor (MIF) is a ubiquitously expressed proinflammatory mediator that has also been implicated in cell growth, cell cycle and carcinogenesis...
  3. Kong Y, Yu X, Tang J, Ouyang X, Huang X, Fingerle Rowson G, et al. Macrophage migration inhibitory factor induces MMP-9 expression: implications for destabilization of human atherosclerotic plaques. Atherosclerosis. 2005;178:207-15 pubmed
    b>Macrophage migration inhibitory factor (MIF) has been shown to participate in both experimental and human atherogenesis. Expression of MMP-9 has been shown to play a role in the instability of atherosclerotic plaque...
  4. Wilson J, Coletta P, Cuthbert R, Scott N, Maclennan K, Hawcroft G, et al. Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology. 2005;129:1485-503 pubmed
    The cytokine macrophage migration inhibitory factor (MIF) is expressed throughout the human gastrointestinal tract. Recently, protumorigenic activity of MIF has been described in several cancer models...
  5. Tereshchenko I, Petrkova J, Mrazek F, Lukl J, Maksimov V, Romaschenko A, et al. The macrophage migration inhibitory factor (MIF) gene polymorphism in Czech and Russian patients with myocardial infarction. Clin Chim Acta. 2009;402:199-202 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) is a cytokine implicated in early and advanced atherosclerosis. The aim of this study was to investigate whether polymorphism of MIF gene is associated with myocardial infarction (MI)...
  6. Denz A, Pilarsky C, Muth D, Ruckert F, Saeger H, Grutzmann R. Inhibition of MIF leads to cell cycle arrest and apoptosis in pancreatic cancer cells. J Surg Res. 2010;160:29-34 pubmed publisher
    ..Gene expression profiling of PDAC revealed an overexpression of the macrophage migration inhibitory factor (MIF), a lymphokine involved in cell-mediated immunity and inflammation, as well as in the ..
  7. Li J, Mo H, Xiong G, Zhang L, He J, Huang Z, et al. Tumor microenvironment macrophage inhibitory factor directs the accumulation of interleukin-17-producing tumor-infiltrating lymphocytes and predicts favorable survival in nasopharyngeal carcinoma patients. J Biol Chem. 2012;287:35484-95 pubmed publisher
    ..We observed high levels of CD154, G-CSF, CXCL1, IL-6, IL-8, and macrophage inhibitory factor (MIF) out of 36 cytokines examined in tumor tissue cultures...
  8. He X, Chen K, Yang J, Li X, Gan H, Liu C, et al. Macrophage migration inhibitory factor promotes colorectal cancer. Mol Med. 2009;15:1-10 pubmed publisher
    A growing body of evidence implicates macrophage migration inhibitory factor (MIF) in tumorigenesis and metastasis...
  9. Xin D, Rendon B, Zhao M, Winner M, McGhee Coleman A, Mitchell R. The MIF homologue D-dopachrome tautomerase promotes COX-2 expression through ?-catenin-dependent and -independent mechanisms. Mol Cancer Res. 2010;8:1601-9 pubmed publisher
    The cytokine/growth factor, macrophage migration inhibitory factor (MIF), contributes to pathologies associated with immune, inflammatory, and neoplastic disease processes...
  10. Shimizu T, Nishihira J, Watanabe H, Abe R, Honda A, Ishibashi T, et al. Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cells. J Biol Chem. 2004;279:13729-37 pubmed
    b>Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has been shown to play a role in wound-healing processes...
  11. Miller E, Li J, Leng L, McDonald C, Atsumi T, Bucala R, et al. Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature. 2008;451:578-82 pubmed publisher
    ..Here we show that macrophage migration inhibitory factor (MIF), an upstream regulator of inflammation, is released in the ischaemic heart, where it ..
  12. Du W, Wright B, Li X, Finke J, Rini B, Zhou M, et al. Tumor-derived macrophage migration inhibitory factor promotes an autocrine loop that enhances renal cell carcinoma. Oncogene. 2013;32:1469-74 pubmed publisher
    The macrophage migration inhibitory factor (MIF) is a hypoxia regulated gene that has a variety of tumorigenic functions...
  13. Llamas Covarrubias M, Valle Y, Navarro Hernández R, Guzmán Guzmán I, Ramirez Dueñas M, Rangel Villalobos H, et al. Serum levels of macrophage migration inhibitory factor are associated with rheumatoid arthritis course. Rheumatol Int. 2012;32:2307-11 pubmed publisher
    ..Many cytokines have been found to be associated with RA pathogenesis and among them is macrophage migration inhibitory factor (MIF)...
  14. Liu M, Hu C. Association of MIF in serum and synovial fluid with severity of knee osteoarthritis. Clin Biochem. 2012;45:737-9 pubmed publisher
    ..This study aims to determine macrophage migration inhibitory factor (MIF) levels in serum and synovial fluid (SF) of patients with knee OA and to analyze the ..
  15. Beswick E, Pinchuk I, Suarez G, Sierra J, Reyes V. Helicobacter pylori CagA-dependent macrophage migration inhibitory factor produced by gastric epithelial cells binds to CD74 and stimulates procarcinogenic events. J Immunol. 2006;176:6794-801 pubmed
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that has recently been implicated in carcinogenesis...
  16. Donn R, Plant D, Jury F, Richards H, Worthington J, Ray D, et al. Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis. J Invest Dermatol. 2004;123:484-7 pubmed
    b>Macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine, is over-expressed in plaques of psoriasis and increased levels are found in the sera of patients with psoriasis...
  17. Baron N, Deuster O, Noelker C, Stuer C, Strik H, Schaller C, et al. Role of macrophage migration inhibitory factor in primary glioblastoma multiforme cells. J Neurosci Res. 2011;89:711-7 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) is a protein that is overexpressed in many tumors, such as colon and prostate cancer, melanoma, and glioblastoma multiforme (GBM)...
  18. Santos L, Lacey D, Yang Y, Leech M, Morand E. Activation of synovial cell p38 MAP kinase by macrophage migration inhibitory factor. J Rheumatol. 2004;31:1038-43 pubmed
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine important in animal models of rheumatoid arthritis (RA)...
  19. Fei B, Lv H, Yang J, Ye Z. Association of MIF-173 gene polymorphism with inflammatory bowel disease in Chinese Han population. Cytokine. 2008;41:44-7 pubmed
    To study whether macrophage migration inhibitory factor (MIF)-173 gene polymorphism correlates with inflammatory bowel disease (IBD) in Chinese Han population...
  20. Ferro E, Mineo J, Ietta F, Bechi N, Romagnoli R, Silva D, et al. Macrophage migration inhibitory factor is up-regulated in human first-trimester placenta stimulated by soluble antigen of Toxoplasma gondii, resulting in increased monocyte adhesion on villous explants. Am J Pathol. 2008;172:50-8 pubmed publisher
    Considering the potential role of macrophage migration inhibitory factor (MIF) in the inflammation process in placenta when infected by pathogens, we investigated the production of this cytokine in chorionic villous explants obtained from ..
  21. Barrilleaux B, Phinney D, Fischer Valuck B, Russell K, Wang G, Prockop D, et al. Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells. Tissue Eng Part A. 2009;15:2335-46 pubmed publisher
    ..This was partly due to a dose-dependent response to macrophage migration inhibitory factor (MIF)...
  22. Coleman A, Rendon B, Zhao M, Qian M, Bucala R, Xin D, et al. Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase. J Immunol. 2008;181:2330-7 pubmed
    ..Recent studies have revealed that macrophage migration inhibitory factor (MIF) expression is increased in lung cancer, particularly non-small cell lung carcinomas (NSCLC)...
  23. Foote A, Briganti E, Kipen Y, Santos L, Leech M, Morand E. Macrophage migration inhibitory factor in systemic lupus erythematosus. J Rheumatol. 2004;31:268-73 pubmed
    To examine associations between serum macrophage migration inhibitory factor (MIF) and disease-related variables and corticosteroid use in patients with systemic lupus erythematosus (SLE)...
  24. Hardman M, Waite A, Zeef L, Burow M, Nakayama T, Ashcroft G. Macrophage migration inhibitory factor: a central regulator of wound healing. Am J Pathol. 2005;167:1561-74 pubmed
    ..expression within the wounds of mice that were wild type or null for the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) in the presence or absence of estrogen...
  25. Schulz R, Marchenko N, Holembowski L, Fingerle Rowson G, Pesic M, Zender L, et al. Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression. J Exp Med. 2012;209:275-89 pubmed publisher
    Intracellular macrophage migration inhibitory factor (MIF) often becomes stabilized in human cancer cells. MIF can promote tumor cell survival, and elevated MIF protein correlates with tumor aggressiveness and poor prognosis...
  26. Cludts S, Decaestecker C, Johnson B, Lechien J, Leroy X, Kindt N, et al. Increased expression of macrophage migration inhibitory factor during progression to hypopharyngeal squamous cell carcinoma. Anticancer Res. 2010;30:3313-9 pubmed
    To examine the presence of macrophage migration inhibitory factor (MIF) quantitatively in relation to neoplastic progression of hypopharyngeal squamous cell carcinoma (HSCC).
  27. Pasupuleti V, Du W, Gupta Y, Yeh I, MONTANO M, Magi Galuzzi C, et al. Dysregulated D-dopachrome tautomerase, a hypoxia-inducible factor-dependent gene, cooperates with macrophage migration inhibitory factor in renal tumorigenesis. J Biol Chem. 2014;289:3713-23 pubmed publisher
    ..We recently described a role for the macrophage migration inhibitory factor (MIF) in ccRCC as an autocrine-signaling molecule with elevated expression in tumor tissues and in ..
  28. Nohara H, Okayama N, Inoue N, Koike Y, Fujimura K, Suehiro Y, et al. Association of the -173 G/C polymorphism of the macrophage migration inhibitory factor gene with ulcerative colitis. J Gastroenterol. 2004;39:242-6 pubmed
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine and has been shown to be involved in the development of chronic murine colitis...
  29. Martinez A, Orozco G, Varadé J, Sánchez López M, Pascual D, Balsa A, et al. Macrophage migration inhibitory factor gene: influence on rheumatoid arthritis susceptibility. Hum Immunol. 2007;68:744-7 pubmed
    The macrophage inhibitory factor (MIF) is a cytokine that has been implicated in several inflammatory and autoimmune diseases, including rheumatoid arthritis, systemic lupus, glomerulonephritis, and multiple sclerosis...
  30. Roger T, Ding X, Chanson A, Renner P, Calandra T. Regulation of constitutive and microbial pathogen-induced human macrophage migration inhibitory factor (MIF) gene expression. Eur J Immunol. 2007;37:3509-21 pubmed
    The cytokine macrophage migration inhibitory factor (MIF) is an important regulator of innate immunity, inflammation and oncogenesis...
  31. Yao K, Shida S, Selvakumaran M, Zimmerman R, Simon E, Schick J, et al. Macrophage migration inhibitory factor is a determinant of hypoxia-induced apoptosis in colon cancer cell lines. Clin Cancer Res. 2005;11:7264-72 pubmed
    ..to identify novel genes mediating sensitivity to hypoxia-induced apoptosis and isolated macrophage migration inhibitory factor (MIF) from the hypoxia-conditioned cell lines...
  32. Jung H, Seong H, Ha H. Direct interaction between NM23-H1 and macrophage migration inhibitory factor (MIF) is critical for alleviation of MIF-mediated suppression of p53 activity. J Biol Chem. 2008;283:32669-79 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) is a pluripotent cytokine that is involved in host immune and inflammatory responses, as well as tumorigenesis. However, the regulatory mechanism of MIF function is unclear...
  33. Lee C, Su M, Huang C, Chen M, Hsu H, Lin C, et al. Macrophage migration inhibitory factor increases cell motility and up-regulates ?v?3 integrin in human chondrosarcoma cells. J Cell Biochem. 2012;113:1590-8 pubmed publisher
    The macrophage migration-inhibitory factor (MIF) is a pro-inflammatory cytokine first known for its effect on macrophage migration and activation...
  34. Rendon B, Roger T, Teneng I, Zhao M, Al Abed Y, Calandra T, et al. Regulation of human lung adenocarcinoma cell migration and invasion by macrophage migration inhibitory factor. J Biol Chem. 2007;282:29910-8 pubmed
    b>Macrophage migration inhibitory factor (MIF) is expressed and secreted in response to mitogens and integrin-dependent cell adhesion...
  35. Bacher M, Deuster O, Aljabari B, Egensperger R, Neff F, Jessen F, et al. The role of macrophage migration inhibitory factor in Alzheimer's disease. Mol Med. 2010;16:116-21 pubmed publisher
    ..and, subsequently, Alzheimer plaques, has been associated in vivo with the immune modulator, macrophage migration inhibitory factor (MIF) (17). To further investigate this association in vivo we used the APP transgenic mouse model...
  36. Dewor M, Steffens G, Krohn R, Weber C, Baron J, Bernhagen J. Macrophage migration inhibitory factor (MIF) promotes fibroblast migration in scratch-wounded monolayers in vitro. FEBS Lett. 2007;581:4734-42 pubmed
    b>MIF was recently redefined as an inflammatory cytokine, which functions as a critical mediator of diseases such as septic shock, rheumatoid arthritis, atherosclerosis, and cancer. MIF also regulates wound healing processes...
  37. Cross J, Rady J, Foss F, Lyons C, Macdonald T, Templeton D. Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF). Biochem J. 2009;423:315-21 pubmed publisher
    ..Using a novel proteomics screen, we identified MIF (macrophage migration inhibitory factor) as the principal target of nutrient ITCs in intact cells...
  38. Shiroeda H, Tahara T, Nakamura M, Shibata T, Nomura T, Yamada H, et al. Association between functional promoter polymorphisms of macrophage migration inhibitory factor (MIF) gene and ulcerative colitis in Japan. Cytokine. 2010;51:173-7 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator. Two functional polymorphisms were identified in the promoter region of MIF gene...
  39. Kindt N, Lechien J, Decaestecker C, Rodriguez A, Chantrain G, Remmelink M, et al. Expression of macrophage migration-inhibitory factor is correlated with progression in oral cavity carcinomas. Anticancer Res. 2012;32:4499-505 pubmed
    We have previously reported that macrophage migration-inhibitory factor (MIF) is associated with an unfavorable prognosis in hypopharyngeal carcinoma...
  40. Wadgaonkar R, Dudek S, Zaiman A, Linz McGillem L, Verin A, Nurmukhambetova S, et al. Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium. J Cell Biochem. 2005;95:849-58 pubmed
    ..922 aa) as bait, identified additional stable MLCK binding partners including the 12 KDa macrophage migration inhibitory factor (MIF)...
  41. Brock S, Rendon B, Yaddanapudi K, Mitchell R. Negative regulation of AMP-activated protein kinase (AMPK) activity by macrophage migration inhibitory factor (MIF) family members in non-small cell lung carcinomas. J Biol Chem. 2012;287:37917-25 pubmed publisher
    ..Because macrophage migration inhibitory factor (MIF) and its functional homolog, d-dopachrome tautomerase (d-DT), have protumorigenic functions ..
  42. Donn R, Alourfi Z, Zeggini E, Lamb R, Jury F, Lunt M, et al. A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis. Arthritis Rheum. 2004;50:1604-10 pubmed
    To establish linkage and replicate the association of macrophage migration inhibitory factor (MIF) with juvenile idiopathic arthritis (JIA)...
  43. Berdeli A, Mir S, Ozkayin N, Serdaroglu E, Tabel Y, Cura A. Association of macrophage migration inhibitory factor -173C allele polymorphism with steroid resistance in children with nephrotic syndrome. Pediatr Nephrol. 2005;20:1566-71 pubmed
    The potential effects of macrophage migration inhibitory factor (MIF) on the natural immune response are due to the inhibition of immune cell activation, which is regulated by glucocorticoids...
  44. Carli C, Metz C, Al Abed Y, Naccache P, Akoum A. Up-regulation of cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic cells by macrophage migration inhibitory factor: involvement of novel kinase signaling pathways. Endocrinology. 2009;150:3128-37 pubmed publisher
    ..Herein, we report that macrophage migration inhibitory factor (MIF), a potent proinflammatory and growth-promoting factor found at elevated concentrations in ..
  45. Sreih A, Ezzeddine R, Leng L, Lachance A, Yu G, Mizue Y, et al. Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus. Arthritis Rheum. 2011;63:3942-51 pubmed publisher
    To study the effect of the innate cytokine macrophage migration inhibitory factor (MIF) on the susceptibility and severity of systemic lupus erythematosus (SLE) in a multinational population of 1,369 Caucasian and African American ..
  46. Kamchybekov U, Figulla H, Gerdes N, Jung C. Macrophage migration inhibitory factor is elevated in obese adolescents. Arch Physiol Biochem. 2012;118:204-9 pubmed publisher
    The prevalence of obesity in childhood and adolescence is continuing rising. Macrophage migration inhibitory factor (MIF) participates in inflammatory and immune responses as a pro-inflammatory cytokine...
  47. Onodera S, Nishihira J, Koyama Y, Majima T, Aoki Y, Ichiyama H, et al. Macrophage migration inhibitory factor up-regulates the expression of interleukin-8 messenger RNA in synovial fibroblasts of rheumatoid arthritis patients: common transcriptional regulatory mechanism between interleukin-8 and interleukin-1beta. Arthritis Rheum. 2004;50:1437-47 pubmed
    ..This study was undertaken to investigate the IL-8 inductive activity of the macrophage migration inhibitory factor (MIF) in RA synovial fibroblasts...
  48. Berdeli A, Ozyurek A, Ulger Z, Gurses D, Levent E, Salar K, et al. Association of macrophage migration inhibitory factor gene -173 G/C polymorphism with prognosis in Turkish children with juvenile rheumatoid arthritis. Rheumatol Int. 2006;26:726-31 pubmed
    The objectives of this study were to determine genotypic and allelic frequencies of macrophage migration inhibitory factor (MIF) gene -173 G/C polymorphism in patients with juvenile rheumatoid arthritis (JRA) and to evaluate the ..
  49. Meyer Siegler K, Vera P, Iczkowski K, Bifulco C, Lee A, Gregersen P, et al. Macrophage migration inhibitory factor (MIF) gene polymorphisms are associated with increased prostate cancer incidence. Genes Immun. 2007;8:646-52 pubmed
    ..Overexpression of macrophage migration inhibitory factor (MIF), an upstream regulator of innate immunity with pleiotropic effects on cell proliferation, ..
  50. Popp J, Bacher M, Kolsch H, Noelker C, Deuster O, Dodel R, et al. Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer's disease. J Psychiatr Res. 2009;43:749-53 pubmed publisher
    ..The macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine which promotes the production of several inflammatory ..
  51. Verjans E, Noetzel E, Bektas N, Schütz A, Lue H, Lennartz B, et al. Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer. BMC Cancer. 2009;9:230 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine and mediator of acute and chronic inflammatory diseases...
  52. Morin M, Bellehumeur C, Therriault M, Metz C, Maheux R, Akoum A. Elevated levels of macrophage migration inhibitory factor in the peripheral blood of women with endometriosis. Fertil Steril. 2005;83:865-72 pubmed
    To evaluate the concentrations of macrophage migration inhibitory factor (MIF) in the peripheral blood of normal women and patients with endometriosis. Retrospective study using ELISA to measure peripheral blood MIF...
  53. Regis E, Barreto de Souza V, Morgado M, Bozza M, Leng L, Bucala R, et al. Elevated levels of macrophage migration inhibitory factor (MIF) in the plasma of HIV-1-infected patients and in HIV-1-infected cell cultures: a relevant role on viral replication. Virology. 2010;399:31-38 pubmed publisher
    The cytokine macrophage migration inhibitory factor (MIF) is involved in the pathogenesis of inflammatory and infectious diseases, however its role in HIV-1 infection is unknown...
  54. Tarnowski M, Grymula K, Liu R, Tarnowska J, Drukala J, Ratajczak J, et al. Macrophage migration inhibitory factor is secreted by rhabdomyosarcoma cells, modulates tumor metastasis by binding to CXCR4 and CXCR7 receptors and inhibits recruitment of cancer-associated fibroblasts. Mol Cancer Res. 2010;8:1328-43 pubmed publisher
    The overexpression of macrophage migration inhibitory factor (MIF) has been observed in many tumors and is implicated in oncogenic transformation and tumor progression...
  55. Liu H, Chen G, Zhang W, Zhu J, Lin Z, Gong Z, et al. Overexpression of macrophage migration inhibitory factor in adenoid cystic carcinoma: correlation with enhanced metastatic potential. J Cancer Res Clin Oncol. 2013;139:287-95 pubmed publisher
    ..b>Macrophage migration inhibitory factor (MIF) is a multi-functional cytokine and has recently emerged as a pro-tumorigenic factor in ..
  56. Lee H, Rhee H, Kang H, Kim H, Min B, Kim N, et al. Macrophage migration inhibitory factor may be used as an early diagnostic marker in colorectal carcinomas. Am J Clin Pathol. 2008;129:772-9 pubmed publisher
    ..Based on intensive filtering, 9 genes were selected for the further evaluations. Among them, macrophage migration inhibitory factor (MIF), inhibin betaA, and chemokine ligand 10 were screened, and the results were compared with ..
  57. Plant B, Gallagher C, Bucala R, Baugh J, Chappell S, Morgan L, et al. Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism. Am J Respir Crit Care Med. 2005;172:1412-5 pubmed
    b>Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator. It contributes toward an exaggerated gram-negative inflammatory response via its ability to induce Toll-like receptor-4 expression...
  58. Liang J, Xiao D, Liu X, Lin Q, Shan Z, Zhu J, et al. High glucose induces apoptosis in AC16 human cardiomyocytes via macrophage migration inhibitory factor and c-Jun N-terminal kinase. Clin Exp Pharmacol Physiol. 2010;37:969-73 pubmed publisher
    1. It is known that high glucose can induce cardiomyocyte apoptosis and that macrophage migration inhibitory factor (MIF) may be involved in the development of diabetes...
  59. Shyu L, Yeh T, Chang H, Lin D, Teng Y, Chen L, et al. Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro. Thromb Res. 2012;129:43-9 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) is an important cytokine in the modulation of inflammatory and immune responses, but its role in coagulation remains to be elucidated...
  60. Awandare G, Martinson J, Were T, Ouma C, Davenport G, Ong echa J, et al. MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia. J Infect Dis. 2009;200:629-37 pubmed publisher
    ..The innate immune mediator macrophage migration inhibitory factor (MIF) plays a critical role in the pathogenesis of SMA...
  61. Cheng R, Deng W, Niu C, Li Y, Fu Y. Expression of macrophage migration inhibitory factor and CD74 in cervical squamous cell carcinoma. Int J Gynecol Cancer. 2011;21:1004-12 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) and CD74 emerge as important players in pathogenesis and angiogenesis of several types of malignant tumors...
  62. Hizawa N, Yamaguchi E, Takahashi D, Nishihira J, Nishimura M. Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and atopy. Am J Respir Crit Care Med. 2004;169:1014-8 pubmed
    b>Macrophage migration inhibitory factor (MIF) is a pleiotrophic lymphocyte and macrophage cytokine; it is likely to play an important role in innate immunity...
  63. Elsby L, Donn R, Alourfi Z, Green L, Beaulieu E, Ray D. Hypoxia and glucocorticoid signaling converge to regulate macrophage migration inhibitory factor gene expression. Arthritis Rheum. 2009;60:2220-31 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory mediator involved in the pathogenesis of rheumatoid arthritis. This study was undertaken to identify the MIF promoter elements responsible for regulating gene expression...
  64. Singh P, Lucchi N, Blackstock A, Udhayakumar V, Singh N. Intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in Central India. PLoS ONE. 2012;7:e51678 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) is a pluripotent factor produced by a variety of cells. It plays an important biological role in the regulation of pregnancy and has been shown to influence malaria pathogenesis...
  65. Pakozdi A, Amin M, Haas C, Martinez R, Haines G, Santos L, et al. Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis. Arthritis Res Ther. 2006;8:R132 pubmed
    ..b>Macrophage migration inhibitory factor (MIF) is a cytokine that induces the production of a large number of proinflammatory molecules and ..
  66. Mittelbronn M, Platten M, Zeiner P, Dombrowski Y, Frank B, Zachskorn C, et al. Macrophage migration inhibitory factor (MIF) expression in human malignant gliomas contributes to immune escape and tumour progression. Acta Neuropathol. 2011;122:353-65 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF), which inhibits apoptosis and promotes angiogenesis, is expressed in cancers suppressing immune surveillance. Its biological role in human glioblastoma is, however, only poorly understood...
  67. Müller I, Müller K, Schönleber H, Karathanos A, Schneider M, Jorbenadze R, et al. Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response. PLoS ONE. 2012;7:e38376 pubmed publisher
    ..b>Macrophage migration inhibitory factor (MIF) is involved in the progress of atherosclerosis and plaque destabilization and plays a ..
  68. Amin M, Haas C, Zhu K, Mansfield P, Kim M, Lackowski N, et al. Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB. Blood. 2006;107:2252-61 pubmed
    ..05). However, Erk1/2 and Jak2 were not involved. Silencing RNA directed against MIF, and inhibitors of Src, PI3K, NFkappaB, anti-VCAM-1, and anti-ICAM-1 significantly inhibited rhMIF-induced adhesion ..
  69. Chuang C, Wang S, Chen W, Chen C, Hor L, Chuang A. Increases in serum macrophage migration inhibitory factor in patients with severe sepsis predict early mortality. Shock. 2007;27:503-6 pubmed
    This prospective study aimed to delineate the association between the serum levels of macrophage migration inhibitory factor (MIF) and the risks of early mortality in 112 patients who presented with clinically severe sepsis...
  70. Hagemann T, Robinson S, Thompson R, Charles K, Kulbe H, Balkwill F. Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis. Mol Cancer Ther. 2007;6:1993-2002 pubmed
    In view of our previous findings that tumor cell-derived macrophage migration inhibitory factor (MIF) increased macrophage-mediated ovarian cancer cell invasiveness in vitro, we investigated the wider significance of ovarian cancer cell-..
  71. Seeber B, Sammel M, Fan X, Gerton G, Shaunik A, Chittams J, et al. Panel of markers can accurately predict endometriosis in a subset of patients. Fertil Steril. 2008;89:1073-81 pubmed
    ..Serum concentrations of interleukin-6, tumor necrosis factor-alpha, macrophage migration inhibitory factor, macrophage chemotactic protein-1, interferon-gamma, leptin, and CA-125 measured by using ELISA ..
  72. Piette C, Deprez M, Roger T, Noel A, Foidart J, Munaut C. The dexamethasone-induced inhibition of proliferation, migration, and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors. J Biol Chem. 2009;284:32483-92 pubmed publisher
    ..b>Macrophage migration inhibitory factor (MIF), an endogenous GC antagonist is up-regulated in GBMs...
  73. Wendt M, Börjesson O, Avik A, Bratt J, Anderstam B, Qureshi A, et al. Macrophage migration inhibitory factor (MIF) and thyroid hormone alterations in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Mol Med. 2013;19:109-14 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine known to be released from lymphocytes, macrophages and endothelial cells and also in animal models shown to be inducible with glucocorticoids (GC)...
  74. Bernhagen J, Krohn R, Lue H, Gregory J, Zernecke A, Koenen R, et al. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med. 2007;13:587-96 pubmed
    The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF...
  75. Oda S, Oda T, Nishi K, Takabuchi S, Wakamatsu T, Tanaka T, et al. Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner. PLoS ONE. 2008;3:e2215 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) is not only a cytokine which has a critical role in several inflammatory conditions but also has endocrine and enzymatic functions...
  76. Nishihira J. Molecular function of macrophage migration inhibitory factor and a novel therapy for inflammatory bowel disease. Ann N Y Acad Sci. 2012;1271:53-7 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) is a unique protein that participates in inflammation, immune responses, and cell growth...
  77. Zhang L, Ye S, Ma G, Tang X, Chen S, He J, et al. The expressions of MIF and CXCR4 protein in tumor microenvironment are adverse prognostic factors in patients with esophageal squamous cell carcinoma. J Transl Med. 2013;11:60 pubmed publisher
    ..In this survey, we aimed to detect the expression levels of MIF and CXCR4 in different cell populations of tumor microenvironments and their association with survivals of patients ..
  78. Hira E, Ono T, Dhar D, El Assal O, Hishikawa Y, Yamanoi A, et al. Overexpression of macrophage migration inhibitory factor induces angiogenesis and deteriorates prognosis after radical resection for hepatocellular carcinoma. Cancer. 2005;103:588-98 pubmed
    b>Macrophage migration inhibitory factor (MIF) is a pivotal cytokine that regulates inflammatory and immune responses...
  79. Gomez L, Sanchez E, Ruiz Narvaez E, Lopez Nevot M, Anaya J, Martin J. Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population. Tissue Antigens. 2007;70:28-33 pubmed
    b>Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that regulates innate and adaptative immunity responses against pathogens. The MIF gene, at 22q11.2, is polymorphic...
  80. Son A, Kato N, Horibe T, Matsuo Y, Mochizuki M, Mitsui A, et al. Direct association of thioredoxin-1 (TRX) with macrophage migration inhibitory factor (MIF): regulatory role of TRX on MIF internalization and signaling. Antioxid Redox Signal. 2009;11:2595-605 pubmed publisher
    ..b>Macrophage migration inhibitory factor (MIF) is a 12 kDa cytokine belonging to the TRX family...
  81. Yu X, Chen H, Liang J, Lin Q, Tan H, Fu Y, et al. Hyperglycemic myocardial damage is mediated by proinflammatory cytokine: macrophage migration inhibitory factor. PLoS ONE. 2011;6:e16239 pubmed publisher
    ..The purpose of this study was to examine the expression levels of macrophage migration inhibitory factor (MIF) and G protein-coupled receptor kinase 2 (GRK2) in patients with early diabetic ..
  82. Radstake T, Sweep F, Welsing P, Franke B, Vermeulen S, Geurts Moespot A, et al. Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor. Arthritis Rheum. 2005;52:3020-9 pubmed
    To study whether genetic variants of macrophage migration inhibitory factor (MIF), the MIF -173G>C and CATT(5-8) alleles, are associated with disease severity and levels of circulating MIF in patients with rheumatoid arthritis (RA)...
  83. Baugh J, Gantier M, Li L, Byrne A, Buckley A, Donnelly S. Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1. Biochem Biophys Res Commun. 2006;347:895-903 pubmed
    b>Macrophage migration inhibitory factor (MIF) is a well-described pro-inflammatory mediator that has also been implicated in the process of oncogenic transformation and tumor progression...
  84. Shi X, Leng L, Wang T, Wang W, Du X, Li J, et al. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity. 2006;25:595-606 pubmed
    The macrophage migration inhibitory factor (MIF) receptor (CD74) was cloned recently, but the signaling mechanism is not evident...
  85. Jian Z, Li J, Ma R, Chen L, Zhong Q, Wang X, et al. Increase of macrophage migration inhibitory factor (MIF) expression in cardiomyocytes during chronic hypoxia. Clin Chim Acta. 2009;405:132-8 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) might play an important role in the myocardium during chronic hypoxia because MIF protects the heart during myocardial ischemia by activating 5'-adenosine monophosphate activated protein kinase ..
  86. Meyer Siegler K, Cox J, Leng L, Bucala R, Vera P. Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation. Cancer Lett. 2010;290:49-57 pubmed publisher
    Mounting evidence suggests that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) may serve as an important link between chronic inflammation and carcinogenesis as evidenced by the increase in serum MIF found in ..
  87. Dambacher J, Staudinger T, Seiderer J, Sisic Z, Schnitzler F, Pfennig S, et al. Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease. Inflamm Bowel Dis. 2007;13:71-82 pubmed
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with increased expression in inflammatory bowel disease...
  88. Li G, Xie J, Lei X, Zhang L. Macrophage migration inhibitory factor regulates proliferation of gastric cancer cells via the PI3K/Akt pathway. World J Gastroenterol. 2009;15:5541-8 pubmed
    To investigate the effects of macrophage migration inhibitory factor (MIF) on proliferation of human gastric cancer MGC-803 cells and expression of cyclin D1 and p27(Kip1) in them, and further determine whether the effects are related to ..
  89. Cho Y, Crichlow G, Vermeire J, Leng L, Du X, Hodsdon M, et al. Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc Natl Acad Sci U S A. 2010;107:11313-8 pubmed publisher
    ..analog AV1013 inhibit the catalytic and chemotactic functions of the proinflammatory protein, macrophage migration inhibitory factor (MIF)...
  90. Swanberg M, McGuigan F, Ivaska K, Gerdhem P, Lerner U, Bucala R, et al. Polymorphisms in the macrophage migration inhibitory factor gene and bone loss in postmenopausal women. Bone. 2010;47:424-9 pubmed publisher
    ..The cytokine macrophage migration inhibitory factor (MIF) has been shown to affect bone density in rodents, and polymorphisms in the human MIF ..
  91. Llamas Covarrubias M, Valle Y, Bucala R, Navarro Hernandez R, Palafox Sánchez C, Padilla Gutiérrez J, et al. Macrophage migration inhibitory factor (MIF): genetic evidence for participation in early onset and early stage rheumatoid arthritis. Cytokine. 2013;61:759-65 pubmed publisher
    b>Macrophage migration inhibitory factor (MIF) is an upstream pro-inflammatory cytokine that is associated with the pathogenesis of autoimmune inflammatory diseases including rheumatoid arthritis (RA)...
  92. Rigante D, Flex A, Federico G, Pola R, Candelli M, Manna R, et al. Serum macrophage migration inhibitory factor (MIF) in the intercritical phase of hereditary periodic fevers and its relationship with the MIF-173G/C polymorphism. Scand J Rheumatol. 2007;36:307-10 pubmed
    To examine the association of the -173 single-nucleotide G/C polymorphism of the macrophage migration inhibitory factor gene (MIF) and serum macrophage migration inhibitory factor (MIF) concentrations in a group of Italian patients with ..