MIF

Summary

Gene Symbol: MIF
Description: macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Alias: GIF, GLIF, MMIF, L-dopachrome isomerase, L-dopachrome tautomerase, macrophage migration inhibitory factor, phenylpyruvate tautomerase
Species: human

Top Publications

  1. pmc Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor
    W Y Weiser
    Department of Medicine, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 86:7522-6. 1989
  2. ncbi The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents
    Jodi B Lubetsky
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 277:24976-82. 2002
  3. ncbi A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis
    J A Baugh
    Laboratory of Medical Biochemistry, The Picower Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Genes Immun 3:170-6. 2002
  4. ncbi Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis
    Michelle Leech
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Locked Bag Number 29, Clayton, Melbourne, Victoria 3168, Australia
    Arthritis Rheum 48:1881-9. 2003
  5. ncbi Human macrophage migration inhibitory factor: a proven immunomodulatory cytokine?
    Alex Kudrin
    Department of Disease Biology, Rheumatology, and Inflammation and Discovery Research, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom
    J Biol Chem 281:29641-51. 2006
  6. pmc Hyperglycemic myocardial damage is mediated by proinflammatory cytokine: macrophage migration inhibitory factor
    Xi Yong Yu
    Medical Research Center, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People s Republic of China
    PLoS ONE 6:e16239. 2011
  7. doi Elevated expression of macrophage migration inhibitory factor correlates with tumor recurrence and poor prognosis of patients with gliomas
    Xiao Bing Wang
    Department of Pathology, Guangdong General Hospital, 106, Zhongshan Road II, Guangzhou, China
    J Neurooncol 106:43-51. 2012
  8. pmc Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor
    H W Sun
    Department of Pharmacology, Yale University, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 93:5191-6. 1996
  9. ncbi Macrophage migration inhibitory factor: a regulator of innate immunity
    Thierry Calandra
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Nat Rev Immunol 3:791-800. 2003
  10. ncbi Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1
    Thierry Roger
    Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Eur J Immunol 35:3405-13. 2005

Detail Information

Publications233 found, 100 shown here

  1. pmc Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor
    W Y Weiser
    Department of Medicine, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 86:7522-6. 1989
    A cDNA encoding a human macrophage migration inhibitory factor (MIF) was isolated, through functional expression cloning in COS-1 cells, from a cDNA library prepared from a lectin-stimulated T-cell hybridoma, T-CEMB...
  2. ncbi The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents
    Jodi B Lubetsky
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 277:24976-82. 2002
    b>Macrophage migration inhibitory factor (MIF) is an immunoregulatory protein that is a potential therapeutic target for a number of inflammatory diseases...
  3. ncbi A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis
    J A Baugh
    Laboratory of Medical Biochemistry, The Picower Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Genes Immun 3:170-6. 2002
    The macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine and regulates the anti-inflammator effects of glucocorticoids...
  4. ncbi Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis
    Michelle Leech
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Locked Bag Number 29, Clayton, Melbourne, Victoria 3168, Australia
    Arthritis Rheum 48:1881-9. 2003
    To study the capacity of macrophage migration inhibitory factor (MIF) to regulate proliferation, apoptosis, and p53 in an animal model of rheumatoid arthritis (RA) and in fibroblast-like synoviocytes (FLS) from humans with RA.
  5. ncbi Human macrophage migration inhibitory factor: a proven immunomodulatory cytokine?
    Alex Kudrin
    Department of Disease Biology, Rheumatology, and Inflammation and Discovery Research, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom
    J Biol Chem 281:29641-51. 2006
    b>Macrophage migration inhibitory factor (MIF) is a pro-inflammatory mediator with the ability to induce various immunomodulatory responses and override glucocorticoid-driven immunosuppression...
  6. pmc Hyperglycemic myocardial damage is mediated by proinflammatory cytokine: macrophage migration inhibitory factor
    Xi Yong Yu
    Medical Research Center, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People s Republic of China
    PLoS ONE 6:e16239. 2011
    ..The purpose of this study was to examine the expression levels of macrophage migration inhibitory factor (MIF) and G protein-coupled receptor kinase 2 (GRK2) in patients with early diabetic ..
  7. doi Elevated expression of macrophage migration inhibitory factor correlates with tumor recurrence and poor prognosis of patients with gliomas
    Xiao Bing Wang
    Department of Pathology, Guangdong General Hospital, 106, Zhongshan Road II, Guangzhou, China
    J Neurooncol 106:43-51. 2012
    b>Macrophage migration inhibitory factor (MIF) plays a critical role in tumorigenesis...
  8. pmc Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor
    H W Sun
    Department of Pharmacology, Yale University, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 93:5191-6. 1996
    b>Macrophage migration inhibitory factor (MIF) was the first cytokine to be described, but for 30 years its role in the immune response remained enigmatic...
  9. ncbi Macrophage migration inhibitory factor: a regulator of innate immunity
    Thierry Calandra
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Nat Rev Immunol 3:791-800. 2003
    For more than a quarter of a century, macrophage migration inhibitory factor (MIF) has been a mysterious cytokine. In recent years, MIF has assumed an important role as a pivotal regulator of innate immunity...
  10. ncbi Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1
    Thierry Roger
    Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Eur J Immunol 35:3405-13. 2005
    The pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) acts as a physiological counter-regulator of the immuno-suppressive effects of glucocorticoids...
  11. pmc Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response
    Iris I Müller
    Kardiologie und Kreislauferkrankungen, Medizinische Klinik III, Eberhard Karls Universitat, Tubingen, Germany
    PLoS ONE 7:e38376. 2012
    ..b>Macrophage migration inhibitory factor (MIF) is involved in the progress of atherosclerosis and plaque destabilization and plays a ..
  12. ncbi Spontaneous and stimulated secretion of monocyte chemotactic protein-1 and macrophage migration inhibitory factor by peritoneal macrophages in women with and without endometriosis
    Ali Akoum
    Département d obstétrique gynécologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Fertil Steril 77:989-94. 2002
    To assess spontaneous and stimulated secretion of monocyte chemotactic protein-1 (MCP-1) and macrophage migration inhibitory factor (MIF) by peritoneal macrophages in women with and without endometriosis.
  13. ncbi Cloning the human gene for macrophage migration inhibitory factor (MIF)
    V Paralkar
    Section on Molecular Structure and Function, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 19:48-51. 1994
    b>Macrophage migration inhibitory factor (MIF) was originally identified as a lymphokine. However, recent work strongly suggests a wider role for MIF beyond the immune system...
  14. doi The macrophage migration inhibitory factor (MIF) gene polymorphism in Czech and Russian patients with myocardial infarction
    Irina P Tereshchenko
    Russian Acad Medical Science Siberian branch, Novosibirsk, Russian Federation
    Clin Chim Acta 402:199-202. 2009
    b>Macrophage migration inhibitory factor (MIF) is a cytokine implicated in early and advanced atherosclerosis. The aim of this study was to investigate whether polymorphism of MIF gene is associated with myocardial infarction (MI).
  15. doi Transcription factor Ap-1 mediates proangiogenic MIF expression in human endothelial cells exposed to Angiotensin II
    Zhi xin Shan
    Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
    Cytokine 53:35-41. 2011
    b>Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine associated with the atherosclerotic process and atherosclerotic plaque stability. MIF was shown to be highly expressed in advanced atherosclerotic lesions...
  16. pmc Macrophage migration inhibitory factor in fetoplacental tissues from preeclamptic pregnancies with or without fetal growth restriction
    Simona Cardaropoli
    Department of Obstetrics and Gynecology, University of Turin, Sant Anna Hospital, Via Ventimiglia 3, 10126 Torino, Italy
    Clin Dev Immunol 2012:639342. 2012
    The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is involved in physiological and pathological processes in pregnancy. MIF maternal serum levels are increased in preeclampsia (PE)...
  17. doi Elevated serum levels of macrophage migration inhibitory factor and their significant correlation with rheumatoid vasculitis disease activity
    Kuninobu Wakabayashi
    Division of Rheumatology, Department of Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Mod Rheumatol 22:59-65. 2012
    b>Macrophage migration inhibitory factor (MIF) is recognized to be an important mediator in several inflammatory disorders, including rheumatoid arthritis (RA) and vasculitis...
  18. pmc Up-regulation of cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic cells by macrophage migration inhibitory factor: involvement of novel kinase signaling pathways
    Cédric Carli
    Laboratoire d endocrinologie de la reproduction, Centre de recherche Hôpital Saint François d Assise, Centre Hospitalier Universitaire de Quebec, Faculte de Medecine, Universite Laval, Quebec, Canada
    Endocrinology 150:3128-37. 2009
    ..Herein, we report that macrophage migration inhibitory factor (MIF), a potent proinflammatory and growth-promoting factor found at elevated concentrations in ..
  19. pmc Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis
    Angela Pakozdi
    University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Arthritis Res Ther 8:R132. 2006
    ..b>Macrophage migration inhibitory factor (MIF) is a cytokine that induces the production of a large number of proinflammatory molecules and ..
  20. ncbi Association of the -173 G/C polymorphism of the macrophage migration inhibitory factor gene with ulcerative colitis
    Hiroaki Nohara
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Yamaguchi, Japan
    J Gastroenterol 39:242-6. 2004
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine and has been shown to be involved in the development of chronic murine colitis...
  21. ncbi A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis
    R P Donn
    Epidemiology Unit, Arthritis Research Campaign, Manchester, UK
    Arthritis Rheum 44:1782-5. 2001
    To determine if polymorphisms of the macrophage migration inhibitory factor (MIF) gene are associated with systemic-onset juvenile idiopathic arthritis (JIA).
  22. ncbi The expression of macrophage migration inhibitory factor 1alpha (MIF 1alpha) in human atherosclerotic plaques is induced by different proatherogenic stimuli and associated with plaque instability
    Alexander Schmeisser
    Medical Clinic II, Department of Cardiology, University of Technology Dresden, PO Box 95, Fetscherstr 74, 01307 Dresden, Germany
    Atherosclerosis 178:83-94. 2005
    b>Macrophage migration inhibitory factor 1alpha (MIF), a cytokine with immunoregulatory functions has been suggested to be involved in atherosclerotic plaque development...
  23. pmc Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner
    Seiko Oda
    Department of Anesthesia, Kyoto University Hospital, Kyoto University, Kyoto, Japan
    PLoS ONE 3:e2215. 2008
    b>Macrophage migration inhibitory factor (MIF) is not only a cytokine which has a critical role in several inflammatory conditions but also has endocrine and enzymatic functions...
  24. ncbi Regulation of human lung adenocarcinoma cell migration and invasion by macrophage migration inhibitory factor
    Beatriz E Rendon
    Molecular Targets Program, J G Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    J Biol Chem 282:29910-8. 2007
    b>Macrophage migration inhibitory factor (MIF) is expressed and secreted in response to mitogens and integrin-dependent cell adhesion...
  25. ncbi Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity
    J B Lubetsky
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Biochemistry 38:7346-54. 1999
    b>Macrophage migration inhibitory factor (MIF) is an important immunoregulatory molecule with a unique ability to suppress the anti-inflammatory effects of glucocorticoids...
  26. ncbi Macrophage migration inhibitory factor (MIF) gene polymorphisms are associated with increased prostate cancer incidence
    K L Meyer-Siegler
    Research and Development 151, Bay Pines VA Healthcare System, Bay Pines, FL 33744, USA
    Genes Immun 8:646-52. 2007
    ..Overexpression of macrophage migration inhibitory factor (MIF), an upstream regulator of innate immunity with pleiotropic effects on cell proliferation, ..
  27. pmc A functional heteromeric MIF receptor formed by CD74 and CXCR4
    Verena Schwartz
    Department of Biochemistry and Molecular Cell Biology, RWTH Aachen University, Aachen, Germany
    FEBS Lett 583:2749-57. 2009
    b>MIF is a chemokine-like inflammatory mediator that triggers leukocyte recruitment by binding to CXCR2 and CXCR4. MIF also interacts with CD74/invariant chain, a single-pass membrane-receptor...
  28. pmc MIF signal transduction initiated by binding to CD74
    Lin Leng
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, 333 Cedar St, P O Box 208031, New Haven, CT 06520 8031, USA
    J Exp Med 197:1467-76. 2003
    b>Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities to have been described, and it has emerged recently to be an important regulator of innate and adaptive immunity...
  29. doi Direct association of thioredoxin-1 (TRX) with macrophage migration inhibitory factor (MIF): regulatory role of TRX on MIF internalization and signaling
    Aoi Son
    Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Antioxid Redox Signal 11:2595-605. 2009
    ..b>Macrophage migration inhibitory factor (MIF) is a 12 kDa cytokine belonging to the TRX family...
  30. pmc Macrophage migration inhibitory factor activates antigen-presenting dendritic cells and induces inflammatory cytokines in ulcerative colitis
    H Murakami
    Third Department of Internal Medicine, Ehime University School of Medicine, Japan
    Clin Exp Immunol 128:504-10. 2002
    The level of macrophage migration inhibitory factor (MIF) and the functions of dendritic cells (DC) are up-regulated in the peripheral blood, and the numbers of MIF-expressing cells and mature DC are increased at the colonic mucosa from ..
  31. ncbi Macrophage migration inhibitory factor in the human endometrium: expression and localization during the menstrual cycle and early pregnancy
    F Arcuri
    Institute of Pathological Anatomy and Histology and Institute of General Physiology, University of Siena, Siena 53100, Italy
    Biol Reprod 64:1200-5. 2001
    b>Macrophage migration inhibitory factor (MIF) was discovered as an activated T-lymphocyte-derived protein that inhibits the random migration of macrophages in vitro...
  32. pmc The dexamethasone-induced inhibition of proliferation, migration, and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors
    Caroline Piette
    Laboratory of Tumor and Developmental Biology, GIGA R, CHU, Liege, Belgium
    J Biol Chem 284:32483-92. 2009
    ..b>Macrophage migration inhibitory factor (MIF), an endogenous GC antagonist is up-regulated in GBMs...
  33. pmc Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase
    Arlixer M Coleman
    Microbiology and Immunology Program, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    J Immunol 181:2330-7. 2008
    ..Recent studies have revealed that macrophage migration inhibitory factor (MIF) expression is increased in lung cancer, particularly non-small cell lung carcinomas (NSCLC)...
  34. ncbi Most of the interleukin 1 receptor antagonist, cathepsin S, macrophage migration inhibitory factor, nerve growth factor, and interleukin 18 release by explants of human adipose tissue is by the non-fat cells, not by the adipocytes
    John N Fain
    Department of Molecular Sciences, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Metabolism 55:1113-21. 2006
    ..to compare the relative release of interleukin 1 receptor antagonist (IL-1Ra), cathepsin S, macrophage migration inhibitory factor (MIF), nerve growth factor (NGF), and interleukin 18 (IL-18) by adipocytes as compared with the ..
  35. ncbi Macrophage migration inhibitory factor evaluation compared with prostate specific antigen as a biomarker in patients with prostate carcinoma
    Katherine L Meyer-Siegler
    Research and Development, Bay Pines Veterans Administration Medical Center, Bay Pines, Florida 33744, USA
    Cancer 94:1449-56. 2002
    ..The objective of this study was to evaluate the clinical usefulness of serum evaluation of the cytokine macrophage migration inhibitory factor (MIF) in patients undergoing routine prostate specific antigen (PSA) screening.
  36. doi Hypoxia and glucocorticoid signaling converge to regulate macrophage migration inhibitory factor gene expression
    Laura M Elsby
    University of Manchester, Manchester, UK
    Arthritis Rheum 60:2220-31. 2009
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory mediator involved in the pathogenesis of rheumatoid arthritis. This study was undertaken to identify the MIF promoter elements responsible for regulating gene expression.
  37. pmc Elevated levels of macrophage migration inhibitory factor (MIF) in the plasma of HIV-1-infected patients and in HIV-1-infected cell cultures: a relevant role on viral replication
    Eduardo G Regis
    Laboratory on Thymus Research, Oswaldo Cruz Institute FIOCRUZ, Rio de Janeiro, RJ, Brazil
    Virology 399:31-8. 2010
    The cytokine macrophage migration inhibitory factor (MIF) is involved in the pathogenesis of inflammatory and infectious diseases, however its role in HIV-1 infection is unknown...
  38. pmc CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex
    Xuerong Shi
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:595-606. 2006
    The macrophage migration inhibitory factor (MIF) receptor (CD74) was cloned recently, but the signaling mechanism is not evident...
  39. doi Expression of macrophage migration inhibitory factor and CD74 in cervical squamous cell carcinoma
    Rong Jie Cheng
    Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Changchun, Jilin, China
    Int J Gynecol Cancer 21:1004-12. 2011
    b>Macrophage migration inhibitory factor (MIF) and CD74 emerge as important players in pathogenesis and angiogenesis of several types of malignant tumors...
  40. ncbi Increased expression of macrophage migration inhibitory factor during progression to hypopharyngeal squamous cell carcinoma
    Stéphanie Cludts
    Laboratory of Anatomy and Cellular Biology, Faculty of Medicine and Pharmacy, University of Mons Hainaut, Mons, Belgium
    Anticancer Res 30:3313-9. 2010
    To examine the presence of macrophage migration inhibitory factor (MIF) quantitatively in relation to neoplastic progression of hypopharyngeal squamous cell carcinoma (HSCC).
  41. ncbi Macrophage migration inhibitory factor in the human prostate: identification and immunocytochemical localization
    F Arcuri
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    Prostate 39:159-65. 1999
    b>Macrophage migration inhibitory factor (MIF) is a lymphokine originally identified for its capacity to inhibit the random migration of macrophages...
  42. doi Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation
    Jérôme Lugrin
    Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH 1011 Lausanne, Switzerland
    Biochim Biophys Acta 1793:1749-58. 2009
    The cytokine macrophage migration inhibitory factor plays a central role in inflammation, cell proliferation and tumorigenesis...
  43. doi Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells
    Bonnie L Barrilleaux
    Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, Louisiana, USA
    Tissue Eng Part A 15:2335-46. 2009
    ..This was partly due to a dose-dependent response to macrophage migration inhibitory factor (MIF)...
  44. ncbi Association of macrophage migration inhibitory factor gene promoter polymorphisms with multiple sclerosis in Turkish patients
    A Akcali
    Department of Neurology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey
    J Int Med Res 38:69-77. 2010
    Elevated levels of macrophage migration inhibitory factor (MIF) have been observed in the cerebrospinal fluid of patients with multiple sclerosis...
  45. doi Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro
    Ling Yuh Shyu
    Institute of Medicine, Chung Shan Medical University, Taiwan, ROC
    Thromb Res 129:43-9. 2012
    b>Macrophage migration inhibitory factor (MIF) is an important cytokine in the modulation of inflammatory and immune responses, but its role in coagulation remains to be elucidated...
  46. doi Increase of macrophage migration inhibitory factor (MIF) expression in cardiomyocytes during chronic hypoxia
    Zhao Jian
    Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, 183 Xinqiao Street, Chongqing 400037, PR China
    Clin Chim Acta 405:132-8. 2009
    b>Macrophage migration inhibitory factor (MIF) might play an important role in the myocardium during chronic hypoxia because MIF protects the heart during myocardial ischemia by activating 5'-adenosine monophosphate activated protein kinase ..
  47. ncbi Elevated levels of macrophage migration inhibitory factor in the peripheral blood of women with endometriosis
    Mathieu Morin
    Laboratoire d endocrinologie de la reproduction, Centre de Recherche, Hopital Saint Francois d Assise, Centre Hospitalier Universitaire de Quebec CHUQ, Faculte de Medecine, Universite Laval, 10 rue de l Espinay, Quebec, PQ, Canada G1L 3L5
    Fertil Steril 83:865-72. 2005
    To evaluate the concentrations of macrophage migration inhibitory factor (MIF) in the peripheral blood of normal women and patients with endometriosis.
  48. ncbi The major binding protein of the interferon antagonist sarcolectin in human placenta is a macrophage migration inhibitory factor
    F Y Zeng
    Abteilung Glykobiochemie und Angewandte Tumorlektinologie, Philipps Universitat, Marburg, Germany
    Arch Biochem Biophys 303:74-80. 1993
    ..major sarcolectin-binding protein is identical to that deduced from the cDNA sequence of a human macrophage migration inhibitory factor (MIF), starting from its third amino acid, over the determined stretch of 22 amino acids...
  49. doi Plasma monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha are increased in patients with polycystic ovary syndrome (PCOS) and associated with adiposity, but unaffected by pioglitazone treatment
    Dorte Glintborg
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervaenget 6, Odense C, Denmark
    Clin Endocrinol (Oxf) 71:652-8. 2009
    ..sensitizing treatment reduces the inflammatory state, but the effect on serum levels of migration inhibitor factor (MIF), monocyte chemoattractant protein (MCP)-1 and macrophage inflammatory protein (MIP)-1alpha have not been evaluated ..
  50. ncbi Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium
    Raj Wadgaonkar
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Cell Biochem 95:849-58. 2005
    ..922 aa) as bait, identified additional stable MLCK binding partners including the 12 KDa macrophage migration inhibitory factor (MIF)...
  51. ncbi Regulation of constitutive and microbial pathogen-induced human macrophage migration inhibitory factor (MIF) gene expression
    Thierry Roger
    Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Eur J Immunol 37:3509-21. 2007
    The cytokine macrophage migration inhibitory factor (MIF) is an important regulator of innate immunity, inflammation and oncogenesis...
  52. ncbi Overexpression of macrophage migration inhibitory factor induces angiogenesis and deteriorates prognosis after radical resection for hepatocellular carcinoma
    Eiji Hira
    Department of Digestive and General Surgery, Faculty of Medicine, Shimane University, Izumo, Japan
    Cancer 103:588-98. 2005
    b>Macrophage migration inhibitory factor (MIF) is a pivotal cytokine that regulates inflammatory and immune responses...
  53. ncbi Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF)
    J Bernhagen
    Picower Institute for Medical Research, Manhasset, New York 11030
    Biochemistry 33:14144-55. 1994
    The cytokine macrophage migration inhibitory factor (MIF) has been identified to be secreted by the pituitary gland and the monocyte/macrophage and to play an important role in endotoxic shock...
  54. doi Macrophage migration inhibitory factor in cardiovascular disease
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, Molekulare Herz Kreislaufforschung, RWTH Aachen University, Aachen, Germany
    Circulation 117:1594-602. 2008
    The highly conserved and archetypical yet atypical cytokine macrophage migration inhibitory factor (MIF) fulfills pleiotropic immune functions in many acute and chronic inflammatory diseases...
  55. ncbi Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous blood
    Sujittra Chaisavaneeyakorn
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Atlanta, Georgia 30341, USA
    J Infect Dis 186:1371-5. 2002
    b>Macrophage migration inhibitory factor (MIF) may play a role in immune responses to malaria during pregnancy by virtue of its ability to activate macrophages and to overcome the immunosuppressive effect of glucocorticoids...
  56. pmc Macrophage migration inhibitory factor is up-regulated in human first-trimester placenta stimulated by soluble antigen of Toxoplasma gondii, resulting in increased monocyte adhesion on villous explants
    Eloísa Amália Vieira Ferro
    Instituto de Ciencias Biomedicas, Universidade Federal de Uberlandia, Av Pará, 1720, Uberlandia, Minas Gerais, Brasil 38405320
    Am J Pathol 172:50-8. 2008
    Considering the potential role of macrophage migration inhibitory factor (MIF) in the inflammation process in placenta when infected by pathogens, we investigated the production of this cytokine in chorionic villous explants obtained from ..
  57. pmc A proinflammatory cytokine inhibits p53 tumor suppressor activity
    J D Hudson
    Unit of Cancer Biology, Institute of Child Health, London WC1N 1EH, United Kingdom
    J Exp Med 190:1375-82. 1999
    ..In both screens, we isolated cDNAs encoding macrophage migration inhibitory factor (MIF), a cytokine that was shown previously to exert both local and systemic proinflammatory ..
  58. ncbi MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
    Jurgen Bernhagen
    Department of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital Aachen, Rheinisch Westfälische Technische Hochschule RWTH Aachen University, D 52074 Aachen, Germany
    Nat Med 13:587-96. 2007
    The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF...
  59. pmc Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer
    Eva Verjans
    Department of Biochemistry and Molecular Cell Biology, RWTH Aachen University Hospital, Aachen, Germany
    BMC Cancer 9:230. 2009
    b>Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine and mediator of acute and chronic inflammatory diseases...
  60. doi High glucose induces apoptosis in AC16 human cardiomyocytes via macrophage migration inhibitory factor and c-Jun N-terminal kinase
    Jia Liang Liang
    Medical Research Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
    Clin Exp Pharmacol Physiol 37:969-73. 2010
    1. It is known that high glucose can induce cardiomyocyte apoptosis and that macrophage migration inhibitory factor (MIF) may be involved in the development of diabetes...
  61. pmc MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia
    Gordon A Awandare
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Infect Dis 200:629-37. 2009
    ..The innate immune mediator macrophage migration inhibitory factor (MIF) plays a critical role in the pathogenesis of SMA.
  62. ncbi Macrophage inhibitory factor, plasminogen activator inhibitor-1, other acute phase proteins, and inflammatory mediators normalize as a result of weight loss in morbidly obese subjects treated with gastric restrictive surgery
    F M H van Dielen
    Department of General Surgery, Nutrition Research Institute Maastricht and University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 89:4062-8. 2004
    ..However, 2 yr after surgery, the inflammatory mediators reach near normal values.These findings may be an explanation for the reduced comorbidity seen in morbidly obese patients after gastric restrictive surgery...
  63. ncbi Macrophage migration inhibitory factor in human pregnancy and labor
    F Ietta
    Department of Physiology, Division of Immunoendocrinology and Reproductive Physiology University of Siena, Siena, Italy
    Am J Reprod Immunol 48:404-9. 2002
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in reproduction. Presently there is no information on the possible involvement of MIF in the onset of labor.
  64. ncbi Macrophage migration inhibitory factor up-regulates the expression of interleukin-8 messenger RNA in synovial fibroblasts of rheumatoid arthritis patients: common transcriptional regulatory mechanism between interleukin-8 and interleukin-1beta
    Shin Onodera
    Department of Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Arthritis Rheum 50:1437-47. 2004
    ..This study was undertaken to investigate the IL-8 inductive activity of the macrophage migration inhibitory factor (MIF) in RA synovial fibroblasts...
  65. ncbi Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1
    John A Baugh
    School of Medicine and Medical Science, The Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biochem Biophys Res Commun 347:895-903. 2006
    b>Macrophage migration inhibitory factor (MIF) is a well-described pro-inflammatory mediator that has also been implicated in the process of oncogenic transformation and tumor progression...
  66. pmc The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia
    Sachin Yende
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    FASEB J 23:2403-11. 2009
    The cytokine, macrophage migration inhibitory factor (MIF), is encoded in a functionally polymorphic locus and subjects with high-expression MIF alleles are at an increased risk of inflammatory disease...
  67. pmc Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB
    M Asif Amin
    Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Blood 107:2252-61. 2006
    ..05). However, Erk1/2 and Jak2 were not involved. Silencing RNA directed against MIF, and inhibitors of Src, PI3K, NFkappaB, anti-VCAM-1, and anti-ICAM-1 significantly inhibited rhMIF-induced adhesion ..
  68. pmc Macrophage migration inhibitory factor: a central regulator of wound healing
    Matthew J Hardman
    Faculty of Life Sciences, University of Manchester, UK
    Am J Pathol 167:1561-74. 2005
    ..expression within the wounds of mice that were wild type or null for the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) in the presence or absence of estrogen...
  69. ncbi Association of MIF-173 gene polymorphism with inflammatory bowel disease in Chinese Han population
    Bao ying Fei
    Department of Gastroenterology, Zhejiang Provincial People s Hospital, Hangzhou 310014, China
    Cytokine 41:44-7. 2008
    To study whether macrophage migration inhibitory factor (MIF)-173 gene polymorphism correlates with inflammatory bowel disease (IBD) in Chinese Han population.
  70. ncbi Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor
    Timothy R D J Radstake
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 52:3020-9. 2005
    To study whether genetic variants of macrophage migration inhibitory factor (MIF), the MIF -173G>C and CATT(5-8) alleles, are associated with disease severity and levels of circulating MIF in patients with rheumatoid arthritis (RA).
  71. pmc Further evidence for increased macrophage migration inhibitory factor expression in prostate cancer
    Katherine L Meyer-Siegler
    Research and Development Service 151, Bay Pines Veterans Administration Medical Center, Bay Pines, FL 33744, USA
    BMC Cancer 5:73. 2005
    b>Macrophage migration inhibitory factor (MIF) is a cytokine associated with prostate cancer, based on histologic evidence and circulating (serum) levels. Recent studies from another laboratory failed to document these results...
  72. pmc Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation
    Katherine L Meyer-Siegler
    Bay Pines VA Healthcare System, Research and Development, Bay Pines, FL 33744, USA
    Cancer Lett 290:49-57. 2010
    Mounting evidence suggests that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) may serve as an important link between chronic inflammation and carcinogenesis as evidenced by the increase in serum MIF found in ..
  73. ncbi Helicobacter pylori CagA-dependent macrophage migration inhibitory factor produced by gastric epithelial cells binds to CD74 and stimulates procarcinogenic events
    Ellen J Beswick
    Department of Pediatrics, University of Texas, Galveston, TX 77555, USA
    J Immunol 176:6794-801. 2006
    b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that has recently been implicated in carcinogenesis...
  74. ncbi Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus
    E Sanchez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Genes Immun 7:433-6. 2006
    The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus...
  75. pmc Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment
    Christian Weber
    Institute for Molecular Cardiovascular Research IMCAR, Aachen, GermanyAachen, Germany
    Proc Natl Acad Sci U S A 105:16278-83. 2008
    We have recently identified the archaic cytokine macrophage migration inhibitory factor (MIF) as a non-canonical ligand of the CXC chemokine receptors CXCR2 and CXCR4 in inflammatory and atherogenic cell recruitment...
  76. ncbi Interleukin-1beta and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression
    Ayumi Honda
    Department of Dermatology, Graduate School of Medicine, University of Toyama, Toyama, Japan
    J Dermatol Sci 49:63-72. 2008
    ..Matrix metalloproteinases (MMP)-1 is a member of the MMP family and degrades types I and III collagens, which are the major structural components of the dermis...
  77. ncbi Macrophage migration inhibitory factor (MIF) promotes fibroblast migration in scratch-wounded monolayers in vitro
    Manfred Dewor
    Department of Biochemistry and Molecular Cell Biology, Institute of Biochemistry, University Hospital RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    FEBS Lett 581:4734-42. 2007
    b>MIF was recently redefined as an inflammatory cytokine, which functions as a critical mediator of diseases such as septic shock, rheumatoid arthritis, atherosclerosis, and cancer. MIF also regulates wound healing processes...
  78. ncbi Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis
    Thorsten Hagemann
    Queen Mary s Medical School, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Mol Cancer Ther 6:1993-2002. 2007
    In view of our previous findings that tumor cell-derived macrophage migration inhibitory factor (MIF) increased macrophage-mediated ovarian cancer cell invasiveness in vitro, we investigated the wider significance of ovarian cancer cell-..
  79. ncbi Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population
    L M Gomez
    Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas CIB, Medellin, Colombia, and Instituto de Parasitología y Biomedicina Lopez Neyra, CSIC, Grenada, Spain
    Tissue Antigens 70:28-33. 2007
    b>Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that regulates innate and adaptative immunity responses against pathogens. The MIF gene, at 22q11.2, is polymorphic...
  80. doi Overexpression of macrophage migration inhibitory factor induces angiogenesis in human breast cancer
    Xiangdong Xu
    Department of Center of Breast Disease, The First Affiliated Hospital, Sun Yat Sen University, 58 Zhongshan Road II, Guangzhou 510080, China
    Cancer Lett 261:147-57. 2008
    b>Macrophage migration inhibitory factor (MIF) is known to be an important contributor to tumor progression. Overexpression of MIF has been reported in different types of tumors...
  81. ncbi Increases in serum macrophage migration inhibitory factor in patients with severe sepsis predict early mortality
    Chia C Chuang
    Department of Emergency Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Shock 27:503-6. 2007
    This prospective study aimed to delineate the association between the serum levels of macrophage migration inhibitory factor (MIF) and the risks of early mortality in 112 patients who presented with clinically severe sepsis...
  82. pmc Association of the macrophage migration inhibitory factor gene polymorphisms with inflammatory bowel disease
    J Oliver
    Gut 56:150-1. 2007
  83. ncbi Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells
    Katherine L Meyer-Siegler
    Research and Development 151, The Bay Pines Veterans Affairs Healthcare System, 10000 Bay Pines Boulevard, Bay Pines, FL 33744, USA
    J Immunol 177:8730-9. 2006
    b>Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, is overexpressed in prostate cancer, but the mechanism by which MIF exerts effects on tumor cells remains undetermined...
  84. ncbi Macrophage migration inhibitory factor promoter polymorphisms and the clinical expression of scleroderma
    Sou Pan Wu
    Yale University School of Medicine, New Haven, Connecticut 06520 8031, USA
    Arthritis Rheum 54:3661-9. 2006
    To investigate the potential association between functional polymorphisms in the gene for the innate mediator, macrophage migration inhibitory factor (MIF), and the clinical expression of systemic sclerosis (SSc).
  85. doi The microsatellite, macrophage migration inhibitory factor -794, may influence gene expression in human mononuclear cells stimulated with E. coli or S. pneumoniae
    S E L Temple
    School of Medicine and Pharmacology RPH Unit, University of Western Australia, Crawley, Australia
    Int J Immunogenet 35:309-16. 2008
    Polymorphisms within the gene encoding macrophage migration inhibitory factor (MIF) have been associated with susceptibility to inflammatory diseases such as rheumatoid arthritis and increased risk of developing sepsis...
  86. ncbi Macrophage migration inhibitory factor gene: influence on rheumatoid arthritis susceptibility
    Alfonso Martinez
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    Hum Immunol 68:744-7. 2007
    The macrophage inhibitory factor (MIF) is a cytokine that has been implicated in several inflammatory and autoimmune diseases, including rheumatoid arthritis, systemic lupus, glomerulonephritis, and multiple sclerosis...
  87. doi Involvement of nuclear factor-kappaB in macrophage migration inhibitory factor gene transcription up-regulation induced by interleukin- 1 beta in ectopic endometrial cells
    Véronique Veillat
    Unite d Endocrinologie de la Reproduction, Centre de Recherche, Hopital Saint Francois d Assise, Centre Hospitalier Universitaire de Quebec, Faculte de Medecine, Universite Laval, Quebec, Canada
    Fertil Steril 91:2148-56. 2009
    To investigate the involvement of the nuclear factor (NF)-kappaB in the interleukin (IL)-1 beta-mediated macrophage migration inhibitory factor (MIF) gene activation.
  88. ncbi Macrophage migration inhibitory factor promotes intestinal tumorigenesis
    Jonathan M Wilson
    Molecular Medicine Unit, University of Leeds, Leeds, United Kingdom
    Gastroenterology 129:1485-503. 2005
    The cytokine macrophage migration inhibitory factor (MIF) is expressed throughout the human gastrointestinal tract. Recently, protumorigenic activity of MIF has been described in several cancer models...
  89. ncbi Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1
    R Kleemann
    Laboratory of Biochemistry Institute for Interfacial Engineering, University of Stuttgart, Germany
    Nature 408:211-6. 2000
    ..b>Macrophage migration inhibitory factor (MIF) is a cytokine that has a critical role in several inflammatory conditions but that also has ..
  90. ncbi Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter
    Oliver Flieger
    Institute for Interfacial Engineering, University of Stuttgart, Nobelstrasse 12, 70569 Stuttgart, Germany
    FEBS Lett 551:78-86. 2003
    The cytokine macrophage migration inhibitory factor (MIF) is inducibly secreted by immune cells and certain other cell types to critically participate in the regulation of the host immune response...
  91. ncbi Macrophage migration inhibitory factor (MIF) expression in human glioblastomas correlates with vascular endothelial growth factor (VEGF) expression
    C Munaut
    Laboratoire de Biologie des Tumeurs et du Developpement, Universite de Liege, Belgium
    Neuropathol Appl Neurobiol 28:452-60. 2002
    b>Macrophage migration inhibitory factor (MIF) is a peptide released upon hypothalamo-pituitary stimulation that acts as a potent endogenous antagonist of the glucocorticoid inhibition of acute inflammatory response and subsequent antigen-..
  92. ncbi Expression of macrophage migration inhibitory factor in human breast cancer: association with nodal spread
    Hiroko Bando
    Breast Unit, Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Tokyo 113 0021, Japan
    Jpn J Cancer Res 93:389-96. 2002
    b>Macrophage migration inhibitory factor (MIF) is known to exert pleiotropic functions including inhibition of macrophage migration, anchoring, and counteraction of the anti-inflammatory and immunosuppressive activity of glucocorticoids...
  93. pmc Up-regulation of macrophage migration inhibitory factor gene and protein expression in glial tumor cells during hypoxic and hypoglycemic stress indicates a critical role for angiogenesis in glioblastoma multiforme
    Michael Bacher
    Institute of Immunology, Philipps University Marburg, Germany
    Am J Pathol 162:11-7. 2003
    ..b>Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine released by leukocytes and by a variety of cells outside of the ..
  94. ncbi Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cells
    Tadamichi Shimizu
    Departments of Dermatology and Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Biol Chem 279:13729-37. 2004
    b>Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has been shown to play a role in wound-healing processes...
  95. ncbi The cytokine macrophage migration inhibitory factor reduces pro-oxidative stress-induced apoptosis
    Mai Tuyet Nguyen
    Laboratory of Biochemistry, Institute for Interfacial Engineering, University of Stuttgart and Fraunhofer Institut für Grenzflächen und Bioverfahrenstechnik, Stuttgart, Germany
    J Immunol 170:3337-47. 2003
    The cytokine macrophage migration inhibitory factor (MIF) exhibits pro- and anti-inflammatory activities and regulates cell proliferation and survival. We investigated the effects of MIF on apoptosis...
  96. ncbi Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis
    Rachelle P Donn
    Arthritis Research Campaign Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK
    J Invest Dermatol 123:484-7. 2004
    b>Macrophage migration inhibitory factor (MIF), an important pro-inflammatory cytokine, is over-expressed in plaques of psoriasis and increased levels are found in the sera of patients with psoriasis...
  97. pmc Release of macrophage migration inhibitory factor and CXCL8/interleukin-8 from lung epithelial cells rendered necrotic by influenza A virus infection
    Ute Arndt
    Institute of Immunology, Philipps University, Marburg, Germany
    J Virol 76:9298-306. 2002
    ..In addition to the release of CXCL8/IL-8, we obtained a massive release of macrophage migration inhibitory factor (MIF) from virus-infected lung cells...
  98. ncbi Immunopathogenic mechanisms in hypertension
    N Lefkos
    Cardiology Unit, Aristotle University of Thessaloniki, Hippokration Hospital, Greece
    Am J Hypertens 8:1141-5. 1995
    ..immunity against arterial wall antigen was studied in all subjects by means of migration inhibitory factor (MIF) against relevant antigen preparation...
  99. ncbi Solid-phase synthesis, isolation and analysis of a mouse protein, the macrophage migration inhibitory factor
    T Kaiser
    , , Munich, Germany
    J Chromatogr A 852:189-95. 1999
    Murine macrophage migration inhibitory factor (mMIF) is an Mr 12,500 protein composed of all natural amino acid residues...
  100. ncbi Effect of vitamin E on production of macrophage migration inhibitory factor (MIF) by macrophages
    W Sakamoto
    Department of Biochemistry, School of Dentistry, Hokkaido University, Sapporo, Japan
    Biofactors 10:139-43. 1999
    b>Macrophage migration inhibitory factor (MIF), a putative cytokine involved in inflammatory and immune responses, was identified in rat peritoneal macrophages by Western blot analysis and its secretion into culture medium by enzyme-linked ..
  101. ncbi Increase in macrophage migration inhibitory factor levels in lacrimal fluid of patients with severe atopic dermatitis
    Nobuyoshi Kitaichi
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, 060 8638, Sapporo, Japan
    Graefes Arch Clin Exp Ophthalmol 244:825-8. 2006
    ..b>Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is associated with the generation of cell-mediated immune ..

Research Grants81

  1. Innate and Adaptive Immune Mechanisms in Arthritis
    Richard Bucala; Fiscal Year: 2009
    ..Since our initial cloning of murine macrophage migration inhibitory factor (MIF), we have focused on the role of this mediator in the pathogenesis of rheumatoid arthritis...
  2. Innate and Adaptive Immune Mechanisms in Arthritis
    RICHARD J BUCALA; Fiscal Year: 2010
    ..Since our initial cloning of murine macrophage migration inhibitory factor (MIF), we have focused on the role of this mediator in the pathogenesis of rheumatoid arthritis...
  3. INNATE AND ADAPTIVE MECHANISMS IN ARTHRITIS
    Richard Bucala; Fiscal Year: 2007
    ..b>Macrophage migration inhibitory factor (MIF) is an upstream regulator of the immune response that is produced both by innate (monocyte/..
  4. MIF AND THE HOST RESPONSE TO INFECTION
    RICHARD J BUCALA; Fiscal Year: 2010
    ..In 1993, we cloned murine macrophage migration inhibitory factor (MIF) as an upstream regulator of innate immunity and mediator of lethal shock...
  5. MIF AND THE HOST RESPONSE TO INFECTION
    Richard Bucala; Fiscal Year: 2007
    ..We have discovered that macrophage migration inhibitory factor (MIF) is an important mediator of innate immunity and upstream regulator of inflammatory cytokine ..
  6. Mechanisms of Rheumatoid Synovial Fibroblast Activation
    Richard Bucala; Fiscal Year: 2006
    ..The central hypothesis is that the cytokine, macrophage migration inhibitory factor (MIF), induces sustained ERK-1/2 activation, invasive phenotype, and suppression of p53-dependent ..
  7. CREB Regulates Adipogenesis and Adipocyte Survival
    Dwight J Klemm; Fiscal Year: 2010
    ..their apoptosis, but also increases expression of intercellular adhesion molecule-1 (ICAM-1), macrophage migration inhibitory factor-1 (MIF-1), macrophage colony stimulating factor-1 (MCSF-1), CXC ligand 13, stromal cell-derived ..
  8. Paraventricular nucleus regulatory mechanisms in stress and hypertension
    COLIN contact SUMNERS; Fiscal Year: 2010
    ..We have recently identified macrophage migration inhibitory factor (MIF) as an intracellular negative regulator of the excitatory actions of Ang II in normotensive ..
  9. Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail Elderly
    George Kuchel; Fiscal Year: 2009
    ..We propose that an atypical cytokine called MIF (macrophage migration inhibitory factor) is involved in the pathways by which urinary retention promotes muscle loss, fibrosis and axonal ..
  10. Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail Elderly
    George Kuchel; Fiscal Year: 2007
    ..We propose that an atypical cytokine called MIF (macrophage migration inhibitory factor) is involved in the pathways by which urinary retention promotes muscle loss, fibrosis and axonal ..
  11. Pathogenesis of Detrusor Underactivity and Urinary Retention in the Frail Elderly
    George A Kuchel; Fiscal Year: 2010
    ..We propose that an atypical cytokine called MIF (macrophage migration inhibitory factor) is involved in the pathways by which urinary retention promotes muscle loss, fibrosis and axonal ..
  12. Role of Cysteine Proteases in Atherosclerosis & Aneurysm
    Guo Ping Shi; Fiscal Year: 2007
    ..By contrast, the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) is highly expressed in these lesions as well as in sera from patients with AAA...
  13. The Lung as a Source of Inflammation in Sepsis
    Edmund Miller; Fiscal Year: 2007
    ..Here, we will examine how the lung can be detrimental to the heart during sepsis. Macrophage migration inhibitory factor (MIF), an important mediator in sepsis, has been shown recently to be a cardiac depressant factor, ..
  14. The Lung as a Source of Inflammation in Sepsis
    Edmund Miller; Fiscal Year: 2009
    ..Here, we will examine how the lung can be detrimental to the heart during sepsis. Macrophage migration inhibitory factor (MIF), an important mediator in sepsis, has been shown recently to be a cardiac depressant factor, ..
  15. Release of MIF protein complexes in vivo: response to inflammation
    PEDRO VERA; Fiscal Year: 2007
    b>Macrophage migration inhibitory factor (MIF), is a pro-inflammatory cytokine produced by the urothelium...
  16. Amplification of tumor hypoxic responses by MIF-dependent HIF stabilization
    Robert A Mitchell; Fiscal Year: 2010
    ..We recently discovered that macrophage migration inhibitory factor (MIF), one of the oldest cytokines ever described, is elevated in PDAC patient's plasma and ..
  17. POR In Inherited Metabolic Liver Diseases
    Pramod Mistry; Fiscal Year: 2007
    ..severity with functional polymorphisms in genes encoding the cytokines that are elevated in GD: Macrophage migration inhibitory factor (MIF), IL 6, IL 10, TNF alpha and TGF beta. 2...
  18. Genetic and Inflammatory Factors in Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2010
    ..Chronic inflammation has also been linked with polymorphisms affecting levels of macrophage migration inhibitory factor (MIF) gene, which induces TNF...
  19. Genetic and Inflammatory Factors in Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2007
    ..Chronic inflammation has also been linked with polymorphisms affecting levels of macrophage migration inhibitory factor (MIF) gene, which induces TNF...
  20. Role of MIF in Rb inactivation and Tumorigenesis
    Robert Mitchell; Fiscal Year: 2007
    ..We recently discovered that the pro-inflammatory cytokine, migration inhibitory factor (MIF) is both necessary and sufficient for mitogen and oncogene-induced cyclin D1 transcription, Cdk4 activity and Rb ..
  21. Cytokine-HPA Interactions During Pregnanacy
    Bradley Pearce; Fiscal Year: 2006
    ..b>Macrophage migration inhibitory factor (MIF) is an immunohormonal molecule that overrides the effect of cortisol on the GR...
  22. Role of Macrophage Migration Inhibitory Factor in Osteoclastogenesis
    Sun Kyeong Lee; Fiscal Year: 2010
    The goal of this proposal is to examine the role of macrophage migration inhibitory factor (MIF) in the regulation of osteoclastogenesis. MIF plays an important role in systemic as well as local inflammatory and immune responses...