MICU1

Summary

Gene Symbol: MICU1
Description: mitochondrial calcium uptake 1
Alias: CALC, CBARA1, EFHA3, MPXPS, calcium uptake protein 1, mitochondrial, ara CALC, atopy-related autoantigen CALC, calcium-binding atopy-related autoantigen 1
Species: human
Products:     MICU1

Top Publications

  1. Hoffman N, Chandramoorthy H, Shamugapriya S, Zhang X, Rajan S, Mallilankaraman K, et al. MICU1 motifs define mitochondrial calcium uniporter binding and activity. Cell Rep. 2013;5:1576-1588 pubmed publisher
    Resting mitochondrial matrix Ca(2+) is maintained through a mitochondrial calcium uptake 1 (MICU1)-established threshold inhibition of mitochondrial calcium uniporter (MCU) activity...
  2. Perocchi F, Gohil V, Girgis H, Bao X, McCombs J, Palmer A, et al. MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature. 2010;467:291-6 pubmed publisher
    ..RNA interference against 13 top candidates highlighted one gene, CBARA1, that we call hereafter mitochondrial calcium uptake 1 (MICU1)...
  3. De Stefani D, Raffaello A, Teardo E, Szabo I, Rizzuto R. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature. 2011;476:336-40 pubmed publisher
    ..Here we have identified in silico a protein (named MCU) that shares tissue distribution with MICU1 (also known as CBARA1), a recently characterized uniporter regulator, is present in organisms in which mitochondrial Ca(2+) uptake was ..
  4. Mallilankaraman K, Doonan P, Cardenas C, Chandramoorthy H, Müller M, Miller R, et al. MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Cell. 2012;151:630-44 pubmed publisher
    ..Here, we demonstrate that the mitochondrial protein MICU1 is required to preserve normal [Ca(2+)](m) under basal conditions...
  5. Sancak Y, Markhard A, Kitami T, Kovács Bogdán E, Kamer K, Udeshi N, et al. EMRE is an essential component of the mitochondrial calcium uniporter complex. Science. 2013;342:1379-82 pubmed publisher
    ..Its molecular components include the EF-hand-containing calcium-binding proteins mitochondrial calcium uptake 1 (MICU1) and MICU2 and the pore-forming subunit mitochondrial calcium uniporter (MCU)...
  6. Csordás G, Golenár T, Seifert E, Kamer K, Sancak Y, Perocchi F, et al. MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²? uniporter. Cell Metab. 2013;17:976-87 pubmed publisher
    ..Recent studies identified MCU as the uniporter's likely pore and MICU1, an EF-hand protein, as its critical regulator...
  7. Baughman J, Perocchi F, Girgis H, Plovanich M, Belcher Timme C, Sancak Y, et al. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature. 2011;476:341-5 pubmed publisher
    ..We recently used comparative proteomics to identify MICU1 (also known as CBARA1), an EF-hand-containing protein that serves as a putative regulator of the uniporter...
  8. Mallilankaraman K, Cardenas C, Doonan P, Chandramoorthy H, Irrinki K, Golenár T, et al. MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. Nat Cell Biol. 2012;14:1336-43 pubmed publisher
    ..Mitochondrial calcium uniporter (MCU) was recently identified as the likely ion-conducting pore. In addition, MICU1 was identified as a mitochondrial regulator of uniporter-mediated Ca(2+) uptake in HeLa cells...
  9. Rabin D, Fuks D, Gelbstein Y. Al solubility in (Ti1-cAlc)NiSn half-Heusler alloy. Phys Chem Chem Phys. 2019;: pubmed publisher
    ..the solubility limit of Al were determined, including an assessment of the maximal Al solubility in the HH (Ti1-cAlc)NiSn phase up to 1400 K...

More Information

Publications87

  1. Lafont A, Wang Y, Chen G, Liao B, Tseng Y, Huang C, et al. Involvement of calcitonin and its receptor in the control of calcium-regulating genes and calcium homeostasis in zebrafish (Danio rerio). J Bone Miner Res. 2011;26:1072-83 pubmed publisher
    ..Embryos injected with CT morpholino (CALC MO) incubated in high-Ca(2+) medium, showed downregulation of CTR together with upregulation on ECaC mRNA ..
  2. Safdar B, Guo X, Johnson C, D ONOFRIO G, Dziura J, Sinusas A, et al. Elevated renalase levels in patients with acute coronary microvascular dysfunction - A possible biomarker for ischemia. Int J Cardiol. 2019;279:155-161 pubmed publisher
    ..We used cardiac Rb-82 PET/CT imaging to diagnose coronary artery disease (CAD/CALC) (defect or coronary calcification) and CMD (depressed coronary flow reserve without CAD) in patients with chest ..
  3. Deng Z, Chaussidon M, Savage P, Robert F, Pik R, Moynier F. Titanium isotopes as a tracer for the plume or island arc affinity of felsic rocks. Proc Natl Acad Sci U S A. 2019;116:1132-1135 pubmed publisher
    ..plume rocks (tholeiitic) are more isotopically fractionated in Ti than differentiated island arc rocks (mainly calc-alkaline)...
  4. Wu H, Liang J, Wang J, Liang W, Gou L, Wu Q, et al. Cezomycin Is Activated by CalC to Its Ester Form for Further Biosynthesis Steps in the Production of Calcimycin in Streptomyces chartreusis NRRL 3882. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..lacking the ability to convert cezomycin to calcimycin allowed the identification of a gene, provisionally named calC, which was involved in the conversion step...
  5. Chrom P, Kawecki M, Stec R, Bodnar L, Szczylik C, Czarnecka A. Biomarkers defining probability of receiving second-line targeted therapy in metastatic renal cell carcinoma. Med Oncol. 2018;35:91 pubmed publisher
    ..910-0.997 per 10 units/l), and albumin concentration (OR 1.924, 95% CI 1.057-3.503 per 1 g/dl). We developed on-line calculator that enables practicing clinicians to estimate SL treatment probability ( http://www.r-calc.com ).
  6. Vakil Monfared R, Mashayekhi F. OX40L gene polymorphism and breast cancer in Iranian population. Exp Oncol. 2018;40:132-135 pubmed
    ..chain reaction-restriction fragment length polymorphism and the statistical analysis was performed by Med Calc. The prevalence of genotype frequencies of AA/AG/GG were 60.9%, 30.08% and 8...
  7. Okunseri C, Wong M, Yau D, McGrath C, Szabo A. The relationship between consumption of beverages and tooth wear among adults in the United States. J Public Health Dent. 2015;75:274-81 pubmed publisher
    ..Drink/juice consumption was ascertained via a Food Frequency Questionnaire processed with Diet*Calc software to obtain the average daily consumption frequency for all queried drinks and juice categories including ..
  8. Bai W, Xu G, Tan M, Yang Z, Zeng L, Wu D, et al. Diffusivities and Atomic Mobilities in bcc Ti-Mo-Zr Alloys. Materials (Basel). 2018;11: pubmed publisher
    ..They showed good agreement. Simulations were implemented by Dictra Module in Thermo-Calc software...
  9. Coufalík P, Krmíček L, Zvěřina O, Meszarosová N, Hladil J, Komárek J. Model of Mercury Flux Associated with Volcanic Activity. Bull Environ Contam Toxicol. 2018;101:549-553 pubmed publisher
    ..rift-related alkaline basaltic rocks; Iceland - hotspot/rift-related tholeiitic basaltic rocks; Japan - island arc calc-alkaline andesites; and Alaska - continental arc calc-alkaline dacites) were studied...
  10. Fuglsang A, Schütz H, Labes D. Reference datasets for bioequivalence trials in a two-group parallel design. AAPS J. 2015;17:400-4 pubmed publisher
    ..proposed consensus obtained via evaluations from six different software packages (R, SAS, WinNonlin, OpenOffice Calc, Kinetica, EquivTest)...
  11. Valenti V, Sciarretta S, Levin M, Shubayev L, Edelstein S, Zia M, et al. An easy and reproducible parameter for the assessment of the pressure gradient in patients with aortic stenosis disease: A magnetic resonance study. J Cardiol. 2015;65:369-76 pubmed publisher
    ..The aim of our study was to evaluate whether the indirect measurement of the aortic gradient (Calc-PG), derived from Gorlin's formula, is a reproducible parameter for gradient assessment...
  12. Ledger A, Borri M, Pope R, Scurr E, Wallace T, Richardson C, et al. Investigating the influence of flip angle and k-space sampling on dynamic contrast-enhanced MRI breast examinations. Acad Radiol. 2014;21:1394-401 pubmed publisher
    ..For each sequence, calculated values of maximum relative enhancement, E(calc), were derived from the Bloch equations and compared to E(max)...
  13. Malov A. Study of isotopes of carbon, thorium, and uranium in travertine and thermal spring samples: implications for effects of changes in geochemical environment and processes. Isotopes Environ Health Stud. 2018;54:78-88 pubmed publisher
    ..inorganic carbon in the ancient thermal water at the time of precipitation of the travertine (14Ccalc)...
  14. Li Y, Zeng X, Zhou X, Li Y. [Cloning, mutagenesis and symbiotic phenotype of three lipid transfer protein encoding genes from Mesorhizobium huakuii 7653R]. Wei Sheng Wu Xue Bao. 2016;56:1901-11 pubmed
    ..MCHK-5577, MCHK-2172 and MCHK-2779 genes encoding proteins belonged to START/RHO alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) superfamily, involved in lipid transport or metabolism, and were identical to M. loti at 95% level...
  15. Birk R, Heifetz E. Variations in biochemical values for common laboratory tests: a comparison among multi-ethnic Israeli women cohort. Ir J Med Sci. 2019;188:249-258 pubmed publisher
    ..tests, including albumin, alkaline phosphatase, calcium, cholesterol, cholesterol LDL and HDL, cholesterol LDL calc., folic acid, globulin, and iron saturation, while the Bedouins exhibited the highest mean values in the creatinine ..
  16. Subotnik J, Vura Weis J, Sodt A, Ratner M. Predicting accurate electronic excitation transfer rates via marcus theory with Boys or Edmiston-Ruedenberg localized diabatization. J Phys Chem A. 2010;114:8665-75 pubmed publisher
    ..the case where both the donor and acceptor occupy equatorial positions on a rigid cyclohexane bridge, we find beta(calc) = 2.8 per C-C bond, compared with the experimental value beta(exp) = 2.6...
  17. Shishido T, Humisto A, Jokela J, Liu L, Wahlsten M, Tamrakar A, et al. Antifungal compounds from cyanobacteria. Mar Drugs. 2015;13:2124-40 pubmed publisher
    ..BIR JV1 and HAN7/1 and in Nostoc spp. 6sf Calc and CENA 219...
  18. Kohlmeier P, Dreyer H, Meunier J. PO-CALC: a novel tool to correct common inconsistencies in the measurement of phenoloxidase activity. J Insect Physiol. 2015;75:80-4 pubmed publisher
    ..To circumvent this issue, we then (2) developed a novel, free and simple R-based program called PO-CALC and (3) demonstrated the robustness of its calculations for the different types of noises...
  19. Troeller A, Garny S, Pachmann S, Kantz S, Gerum S, Manapov F, et al. Stereotactic radiotherapy of intrapulmonary lesions: comparison of different dose calculation algorithms for Oncentra MasterPlan®. Radiat Oncol. 2015;10:51 pubmed publisher
    ..plans were initially calculated in Oncentra MasterPlan® using a PB algorithm and recalculated with CC (CCre-calc)...
  20. Silva F, Torres R, Silva L, Ventura H, Silva F, Carneiro A, et al. Genetic evaluation of milk yield in Alpine goats for the first four lactations using random regression models. Genet Mol Res. 2014;13:10943-51 pubmed publisher
    ..The WOMBAT software was used to estimate the variance components and predict the breeding values. The CALC software was adopted to calculate the percentage of coincidence between the ranking of the animals and the animals ..
  21. Billotte T, Daloz D, Rouat B, Tirand G, Kennedy J, Robin V, et al. Microsegregation Model Including Convection and Tip Undercooling: Application to Directional Solidification and Welding. Materials (Basel). 2018;11: pubmed publisher
    ..The experimental results were compared with Thermo-Calc calculations to verify their accuracy...
  22. Ware M, Belgio E, Ruban A. Photoprotective capacity of non-photochemical quenching in plants acclimated to different light intensities. Photosynth Res. 2015;126:261-74 pubmed publisher
    ..II (PSII) yield in comparison to high-light grown plants, and higher calculated dark fluorescence level (F'o calc.) than the measured one (F'o act.)...
  23. Codillo E, Le Roux V, Marschall H. Arc-like magmas generated by mélange-peridotite interaction in the mantle wedge. Nat Commun. 2018;9:2864 pubmed publisher
    ..contributions of mélanges hybridizing the mantle produce a range of primary arc magmas, from tholeiitic to calc-alkaline...
  24. Flore R, Ponziani F, Tinelli G, Arena V, Fonnesu C, Nesci A, et al. New modalities of ultrasound-based intima-media thickness, arterial stiffness and non-coronary vascular calcifications detection to assess cardiovascular risk. Eur Rev Med Pharmacol Sci. 2015;19:1430-41 pubmed
    ..to describe a novel UltraSound-Based Carotid, Aortic and Lower limbs Calcification Score (USB-CALCs, simply named CALC), allowing to quantify peripheral calcifications...
  25. Charrieau L, Filipsson H, Nagai Y, Kawada S, Ljung K, Kritzberg E, et al. Decalcification and survival of benthic foraminifera under the combined impacts of varying pH and salinity. Mar Environ Res. 2018;138:36-45 pubmed publisher
    ..Finally, we highlight the ability of foraminifera to survive under Ωcalc < 1, and that high salinity and [Ca2+] as building blocks are crucial for the foraminiferal ..
  26. López López D, Vilar Fernández J, Barros García G, Losa Iglesias M, Palomo López P, Becerro de Bengoa Vallejo R, et al. Foot Arch Height and Quality of Life in Adults: A Strobe Observational Study. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..Changes related to the foot structure were analyzed using Area Calc version 2...
  27. Cuyler E, Byrne R. Spectrophotometric calibration procedures to enable calibration-free measurements of seawater calcium carbonate saturation states. Anal Chim Acta. 2018;1020:95-103 pubmed publisher
    ..between Ωspec and Ω calculated conventionally from measured total alkalinity and pH (Ωcalc) was -0.11% ± 0...
  28. Kent E, Breen N, Lewis D, de Moor J, Smith A, Seibel N. US trends in survival disparities among adolescents and young adults with non-Hodgkin lymphoma. Cancer Causes Control. 2015;26:1153-62 pubmed publisher
    ..Absolute and relative disparities were computed using HD*Calc. Whether a significant linear trend was present was evaluated using Joinpoint...
  29. Klein Laansma C, Jansen J, van Tilborgh A, van der Windt D, Mathie R, Rutten A. Semi-standardised homeopathic treatment of premenstrual syndrome with a limited number of medicines: feasibility study. Homeopathy. 2010;99:192-204 pubmed publisher
    ..The medicines selected (in rank order) were Sep, Nat-m, Lach, Cimic, Lac-c, Puls, Calc, Lil-t, Mag-p, Mag-c, Phos. In a feasibility study 20 homeopathic doctors used the protocol in daily practice...
  30. Richardson Sanchez T, Tieu W, Gotsbacher M, Telfer T, Codd R. Exploiting the biosynthetic machinery of Streptomyces pilosus to engineer a water-soluble zirconium(iv) chelator. Org Biomol Chem. 2017;15:5719-5730 pubmed publisher
    ..2; m/zcalc = 855.3), with supporting HRMS data...
  31. Laloo J, Laloo N, Rhyman L, Ramasami P. ExcelAutomat: a tool for systematic processing of files as applied to quantum chemical calculations. J Comput Aided Mol Des. 2017;31:667-673 pubmed publisher
    ..The code in ExcelAutomat was adapted to work with the platform-independent open-source LibreOffice Calc, which also supports VBA...
  32. Breen N, Lewis D, Gibson J, Yu M, Harper S. Assessing disparities in colorectal cancer mortality by socioeconomic status using new tools: health disparities calculator and socioeconomic quintiles. Cancer Causes Control. 2017;28:117-125 pubmed publisher
    ..by SES, using a scientifically rigorous and reproducible approach with publicly available online tools, HD*Calc and NCI SES Quintiles...
  33. Lear S, Cobb S. Pep-Calc.com: a set of web utilities for the calculation of peptide and peptoid properties and automatic mass spectral peak assignment. J Comput Aided Mol Des. 2016;30:271-7 pubmed publisher
    ..A suite of two web utilities: Peptide Calculator and Peptoid Calculator, available free at http://www.pep-calc.com, are presented...
  34. Iskandar K, Hanna P, Salameh P, Raad E. Antibiotic consumption in non-teaching Lebanese hospitals: A cross-sectional study. J Infect Public Health. 2016;9:618-25 pubmed publisher
    ..system and Defined Daily Dose (ATC/DDD) recommended by the World Health Organization and compiling data on ABC Calc software version 3.1. Results show that the average antibiotic consumption excluding pediatric cases is 72...
  35. Manzoni A, Daoud H, Voelkl R, Glatzel U, Wanderka N. Influence of W, Mo and Ti trace elements on the phase separation in Al8Co17Cr17Cu8Fe17Ni33 based high entropy alloy. Ultramicroscopy. 2015;159 Pt 2:265-71 pubmed publisher
    ..Results of the investigations will be discussed in terms of microstructure, hardness and coherence with Thermo Calc predictions.
  36. Ben Ayed R, Ben Hassen H, Ennouri K, Rebai A. Genetic Markers Analyses and Bioinformatic Approaches to Distinguish Between Olive Tree (Olea europaea L.) Cultivars. Interdiscip Sci. 2016;8:366-373 pubmed
    ..sampled from different Mediterranean countries was assessed using 5 SNP markers (FAD2.1; FAD2.3; CALC; SOD and ANTHO3) located in four different genes...
  37. Conchedda M, Caddori A, Caredda A, Capra S, Bortoletti G. Degree of calcification and cyst activity in hepatic cystic echinococcosis in humans. Acta Trop. 2018;182:135-143 pubmed publisher
    ..Cysts were classified into 4 groups according to calcification extent: CALC 0 (no calcification); CALC 1 (scattered punctate calcifications); CALC 2 (large coarse segmental/partial ..
  38. Bukvetskii B, Kalinovskaya I. Crystal Structure, Luminescence and Triboluminescence of the Complex [Eu(NO3)23hmpa] NO3·HQuin. J Fluoresc. 2017;27:773-779 pubmed publisher
    ..8193(3), b = 12.2877(2), c = 27.6516(5) Å, пр. гр. Pca2(1), Z = 4, ρ calc. . = 1.427 g/сm3...
  39. Karagiannis G, Pastoriza J, Wang Y, Harney A, Entenberg D, Pignatelli J, et al. Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism. Sci Transl Med. 2017;9: pubmed publisher
    Breast cancer cells disseminate through TIE2/MENACalc/MENAINV-dependent cancer cell intravasation sites, called tumor microenvironment of metastasis (TMEM), which are clinically validated as prognostic markers of ..
  40. Vanorio T, Kanitpanyacharoen W. ROCK PHYSICS. Rock physics of fibrous rocks akin to Roman concrete explains uplifts at Campi Flegrei Caldera. Science. 2015;349:617-21 pubmed publisher
    ..The basement is a calc-silicate rock housing hydrothermal decarbonation reactions, which provide lime-rich fluids...
  41. Severinghaus J. Eight sages over five centuries share oxygen's discovery. Adv Physiol Educ. 2016;40:370-6 pubmed publisher
    ..In 1744, Joseph Priestley (1733-1804) in England discovered how to make part of air by heating red calc of mercury. He found it brightened a flame and supported life in a mouse in a sealed bottle...
  42. Areas E, Bronsato B, Pereira T, Guedes G, Miranda F, Kummerle A, et al. Novel CoIII complexes containing fluorescent coumarin-N-acylhydrazone hybrid ligands: Synthesis, crystal structures, solution studies and DFT calculations. Spectrochim Acta A Mol Biomol Spectrosc. 2017;187:130-142 pubmed publisher
    ..found for CoIII?CoII (S=1/2), compared with experimental values vs SHE (E°calc=-0.37, -0.36 and -0.32V vs E°exp.=-0.371, -0.406 and -0...
  43. Bukvetskii B, Shishov A, Mirochnik A. Triboluminescence and crystal structure of the centrosymmetric complex [Tb(NO3 )2 (Acac)(Phen)2 ]·H2 O. Luminescence. 2016;31:1329-1334 pubmed publisher
    ..2298(1), b = 9.6492(1), c = 13.2745(1) Å, β = 101.290(1), space group P2/n, Z = 2, ρcalc = 1.790 g/cm3 ...
  44. Su H, Jiang S, Zhang D, Wu X. Partial Melting of Subducted Sediments Produced Early Mesozoic Calc-alkaline Lamprophyres from Northern Guangxi Province, South China. Sci Rep. 2017;7:4864 pubmed publisher
    ..Here, we report a comprehensive geochemical study that demonstrates that the newly identified Early Mesozoic calc-alkaline lamprophyres in the northern Guangxi Province, southeastern Yangtze Block in South China were likely ..
  45. Ottiger P, Köppel H, Leutwyler S. Excitonic splittings in molecular dimers: why static ab initio calculations cannot match them. Chem Sci. 2015;6:6059-6068 pubmed publisher
    ..The excitonic splittings ?calc predicted by ab initio methods are 5-25 times larger than the experimental excitonic splittings ?
  46. Rodríguez E, Bach A, Devant M, Aris A. Is calcitonin an active hormone in the onset and prevention of hypocalcemia in dairy cattle?. J Dairy Sci. 2016;99:3023-3030 pubmed publisher
    The objective of this study was to assess the potential importance of calcitonin (CALC) in the onset of subclinical hypocalcemia (experiment 1) and in the physiological mechanisms underlying the prevention of bovine hypocalcemia under ..
  47. Bizkarguenaga E, Zabaleta I, Iparraguirre A, Aguirre J, Fernández L, Berger U, et al. Enrichment of perfluorinated alkyl substances on polyethersulfone using 1-methylpyperidine as ion-pair reagent for the clean-up of carrot and amended soil extracts. Talanta. 2015;143:263-270 pubmed publisher
    ..were obtained according to the one-way analysis of variance for peel, core, leaves as well as amended soil (F(Calc)=2.59, 5.06, 5.82 and 2.34 <F(Crit)=7.71)...
  48. O Neal P, McClellan L, Jarosinski J. A new model in teaching undergraduate research: A collaborative approach and learning cooperatives. Nurse Educ Pract. 2016;18:80-4 pubmed publisher
    ..The purpose of this Collaborative Approach and Learning Cooperatives (CALC) Model is to foster working relations between faculty and hospital administrators, maximize small group learning of ..
  49. Panichev A, Popov V, Chekryzhov I, Seryodkin I, Stolyarova T, Zakusin S, et al. Rare earth elements upon assessment of reasons of the geophagy in Sikhote-Alin region (Russian Federation), Africa and other world regions. Environ Geochem Health. 2016;38:1255-1270 pubmed
    ..By composition of rock-forming oxides, the tuffs refer to high-potassium calc-alkaline series...
  50. Li Y, Zhang Y, Fang S, Liu S, Liu X, Li M, et al. Analysis of inequality in maternal and child health outcomes and mortality from 2000 to 2013 in China. Int J Equity Health. 2017;16:66 pubmed publisher
    ..The newly developed HD*Calc software by the World Health Organization (WHO) was employed as a tool for the health inequality assessment...
  51. Dabrowska M, Starek M, Komsta Ł, Szafrański P, Stasiewicz Urban A, Opoka W. Assessment of the chromatographic lipophilicity of eight cephalosporins on different stationary phases. Eur J Pharm Sci. 2017;101:115-124 pubmed publisher
    ..logk'IAM) were correlated with the lipophilicity, expressed as values of the log calculated (logPcalc) and experimental (logPexp(shake-flask)) partition coefficient...
  52. Liberale G, Vankerckhove S, Galdon M, Donckier V, Larsimont D, Bourgeois P. Fluorescence imaging after intraoperative intravenous injection of indocyanine green for detection of lymph node metastases in colorectal cancer. Eur J Surg Oncol. 2015;41:1256-60 pubmed publisher
    ..All LNs were also explored for their fluorescence, and tumor to background ratio (TBR) was calculated with IC-Calc 2.0 program. One patient had two retroperitoneal lymph node metastases and one mesocolic on a pre-operative work-up...
  53. Tsai M, Phillips C, Ranaghan M, Tsai C, Wu Y, Willliams C, et al. Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex. elife. 2016;5: pubmed publisher
    ..a second function of EMRE: to maintain tight MICU regulation of the MCU pore, a role that requires EMRE to bind MICU1 using its conserved C-terminal polyaspartate tail...
  54. Chakraborty P, Mustafi S, Xiong X, Dwivedi S, Nesin V, Saha S, et al. MICU1 drives glycolysis and chemoresistance in ovarian cancer. Nat Commun. 2017;8:14634 pubmed publisher
    ..we demonstrate that the gatekeeper of mitochondrial Ca2+ uptake, Mitochondrial Calcium Uptake 1 (MICU1/CBARA1) drives aerobic glycolysis in ovarian cancer...
  55. Matesanz Isabel J, Arias Del Val J, Alvarez Illera P, Fonteriz R, Montero M, Alvarez J. Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake. Biochim Biophys Acta. 2016;1858:1110-7 pubmed publisher
    b>MICU1 and MICU2 are the main regulators of the mitochondrial Ca(2+)-uniporter (MCU), but their precise functional role is still under debate...
  56. Nishida K, Nakatsuma K, Shiomi H, Natsuaki M, Kawai K, Morimoto T, et al. Second-Generation vs. First-Generation Drug-Eluting Stents in Patients With Calcified Coronary Lesions?- Pooled Analysis From the RESET and NEXT Trials. Circ J. 2017;: pubmed publisher
    ..G1-DES and G2-DES were implanted in 299 and 1,033 patients, respectively, in the Calc stratum (?1 lesion with moderate/severe calcification), and 1,208 and 3,550 patients, respectively, in the Non-calc ..
  57. Azam M, Al Resayes S, Soliman S, Trzesowska Kruszynska A, Kruszynski R, Khan Z. A (salicylaldiminato)Pt(II) complex with dimethylpropylene linkage: Synthesis, structural characterization and antineoplastic activity. J Photochem Photobiol B. 2017;176:150-156 pubmed publisher
    ..The electronic transition band at 408.0nm (calc. 424.3nm) is assigned to HOMO?LUMO (96%) excitation...
  58. Arvizo R, Moyano D, Saha S, Thompson M, Bhattacharya R, Rotello V, et al. Probing novel roles of the mitochondrial uniporter in ovarian cancer cells using nanoparticles. J Biol Chem. 2013;288:17610-8 pubmed publisher
    ..Our investigations led to the identification of MICU1, regulator of mitochondrial calcium uniporter, as a key molecule conferring cancer cells with resistance to (+)..
  59. Chen K, Hsu L, Wu C, Chang S, Huang H, Chen W. CBARA1 plays a role in stemness and proliferation of human embryonic stem cells. PLoS ONE. 2013;8:e63653 pubmed publisher
    ..In this study, we identified a mitochondrial gene, CBARA1, that is expressed in undifferentiated hESCs and that is down-regulated rapidly after cellular differentiation...
  60. Kamer K, Mootha V. MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter. EMBO Rep. 2014;15:299-307 pubmed publisher
    The mitochondrial uniporter is a selective Ca(2+) channel regulated by MICU1, an EF hand-containing protein in the organelle's intermembrane space. MICU1 physically associates with and is co-expressed with a paralog, MICU2...
  61. Wang L, Yang X, Li S, Wang Z, Liu Y, Feng J, et al. Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. EMBO J. 2014;33:594-604 pubmed publisher
    ..Ca(2+) uniporter (MCU), which is the pore-forming subunit of a Ca(2+) channel, and mitochondrial calcium uptake 1 (MICU1), which is the regulator of MCU, are essential in this event...
  62. Tsai L, Chan G, Nangle S, Shimizu Albergine M, Jones G, Storm D, et al. Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay. Genes Brain Behav. 2012;11:837-47 pubmed publisher
  63. Safari R, Salimi R, Tunca Z, Ozerdem A, Ceylan D, Sakizli M. Mutation/SNP analysis in EF-hand calcium binding domain of mitochondrial Ca[Formula: see text] uptake 1 gene in bipolar disorder patients. J Integr Neurosci. 2016;15:163-73 pubmed publisher
    ..b>MICU1 is linked with MCU and has two canonical EF hands that are vital for its activity and regulates MCU-mediated Ca[..
  64. Petrungaro C, Zimmermann K, Küttner V, Fischer M, Dengjel J, Bogeski I, et al. The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake. Cell Metab. 2015;22:721-33 pubmed publisher
    ..Among the interaction partners of Mia40 is MICU1-the regulator of the mitochondrial Ca(2+) uniporter (MCU), which transfers Ca(2+) across the inner membrane...
  65. Natter S, Seiberler S, Hufnagl P, Binder B, Hirschl A, Ring J, et al. Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients. FASEB J. 1998;12:1559-69 pubmed
    ..Via binding to antigen presenting cells as well as to effector cells, IgE autoantigen immune complexes may contribute to exacerbation and/or perpetuation of severe atopic diseases even in the absence of exogenous allergens. ..
  66. Long J, Zhang Z, Liu Z, Xu Y, Ge C. Loss of heterozygosity at the calcium regulation gene locus on chromosome 10q in human pancreatic cancer. Asian Pac J Cancer Prev. 2015;16:2489-93 pubmed
    ..The candidate genes with LOH identified in this study were MCU, MICU1 and OIT3 on chromosome 10...
  67. Hoffman N, Chandramoorthy H, Shanmughapriya S, Zhang X, Vallem S, Doonan P, et al. SLC25A23 augments mitochondrial Ca²? uptake, interacts with MCU, and induces oxidative stress-mediated cell death. Mol Biol Cell. 2014;25:936-47 pubmed publisher
    ..In addition, SLC25A23 interacts with mitochondrial Ca(2+) uniporter (MCU; CCDC109A) and MICU1 (CBARA1) while also increasing IMCU...
  68. Logan C, Szabadkai G, Sharpe J, Parry D, Torelli S, Childs A, et al. Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. Nat Genet. 2014;46:188-93 pubmed publisher
    ..in the inner mitochondrial membrane, which comprises MCU, a Ca(2+)-selective ion channel, and its regulator, MICU1. Here we report mutations of MICU1 in individuals with a disease phenotype characterized by proximal myopathy, ..
  69. Alam M, Groschner L, Parichatikanond W, Kuo L, Bondarenko A, Rost R, et al. Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic β-cells. J Biol Chem. 2012;287:34445-54 pubmed publisher
    ..mitochondrial Ca(2+) sequestration in clonal INS-1 832/13 pancreatic β-cells: the mitochondrial Ca(2+) uptake 1 (MICU1), mitochondrial Ca(2+) uniporter (MCU), uncoupling protein 2 (UCP2), and leucine zipper EF-hand-containing ..
  70. Tian Y, Qin L, Qiu H, Shi D, Sun R, Li W, et al. RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca2+/MICU1 dependent mitochondrial signaling. Oncotarget. 2015;6:29614-25 pubmed publisher
    ..flooding of calcium ions (Ca(2+)) into the mitochondrial, and decreased the expression of the Ca(2+) gatekeeper MICU1 and its location on the mitochondrial...
  71. Lima W, Marques Oliveira G, da Silva T, Chaves V. Role of calcitonin gene-related peptide in energy metabolism. Endocrine. 2017;58:3-13 pubmed publisher
    ..peptide (CGRP) is a neuropeptide produced by alternative tissue-specific splicing of the primary transcript of the CALC genes...
  72. Patron M, Checchetto V, Raffaello A, Teardo E, Vecellio Reane D, Mantoan M, et al. MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity. Mol Cell. 2014;53:726-37 pubmed publisher
    ..shown to depend on a complex composed of an inner-membrane channel (MCU and MCUb) and regulatory subunits (MICU1, MCUR1, and EMRE)...
  73. Kamer K, Grabarek Z, Mootha V. High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter. EMBO Rep. 2017;18:1397-1411 pubmed publisher
    ..It is regulated by two paralogous EF-hand proteins-MICU1 and MICU2, but the mechanism is unknown...
  74. Bordicchia M, Battistoni I, Mancinelli L, Giannini E, Refi G, Minardi D, et al. Cannabinoid CB1 receptor expression in relation to visceral adipose depots, endocannabinoid levels, microvascular damage, and the presence of the Cnr1 A3813G variant in humans. Metabolism. 2010;59:734-41 pubmed publisher
    ..Increased VAT is associated with increased perirenal VAT endocannabinoid tone, which in turn correlates with increased MVDa. Endocannabinoid overactivity might be involved in human visceral obesity and its renal complications. ..
  75. Waldeck Weiermair M, Malli R, Parichatikanond W, Gottschalk B, Madreiter Sokolowski C, Klec C, et al. Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.). Sci Rep. 2015;5:15602 pubmed publisher
    ..Mitochondrial calcium uptake 1 (MICU1) was identified as key regulator of the mitochondrial Ca(2+) uniporter (MCU) that together with the essential MCU ..
  76. Hwang L, Yang S, Chuang C, Lee G. An Optimized Synthesis, Molecular Structure and Characterization of Benzylic Derivatives of 1,2,4-Triazin-3,5(2H,4H)-dione. Molecules. 2017;22: pubmed publisher
    ..0527(12) Å, β = 105.961(2)°, V = 1482.3(2) ų, Z = 4, resulting in a density Dcalc of 1.314 g/cm³...
  77. Bhosale G, Sharpe J, Koh A, Kouli A, Szabadkai G, Duchen M. Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics. Biochim Biophys Acta Mol Cell Res. 2017;1864:1009-1017 pubmed publisher
    Loss of function mutations of the protein MICU1, a regulator of mitochondrial Ca2+ uptake, cause a neuronal and muscular disorder characterised by impaired cognition, muscle weakness and an extrapyramidal motor disorder...
  78. Werwein A, Maaß F, Dorsch L, Janka O, Pöttgen R, Hansen T, et al. Hydrogenation Properties of Laves Phases LnMg2 (Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Ho, Er, Tm, Yb). Inorg Chem. 2017;: pubmed publisher
    ..sub>B, respectively, in good agreement with the calculated magnetic moments of the free trivalent rare-earth cations (?calc(Ce3+) = 2.54 ?B; ?calc(Nd3+) = 3.62 ?B).